POPULARITY
From the climax of your story to those final words, what’s an author to do? The group talks about wrapping up plot lines and reminds folks about keeping your promise to the reader. Tracey points out how to end a novel within a series versus a stand-alone, Jess cautions against letting subplots fizzle out, and Anne laments the curse of Episode Fourteen. QUOTE: “The beautiful part of writing is that you don’t have to get it right the first time, unlike, say, a brain surgeon.” – Robert Cormier CREDITS: This episode of Your Writing Does Not Suck was recorded and edited by Anne M. Belen.
Hey there herpsters, it's Episode Fourteen! What shall we talk about? Let's ask the triumphant dude on the left, the one with the little viper in a tube. That's Justin Elden, the viper is Armenian (Montivipera raddei), and guess where they are? In this episode, I talk with Justin about his involvement with the St. Louis Zoo's mountain viper conservation project, (be sure to check out the link for more info and cool photos). Justin and I both grew up in the St. Louis area, and we had a lot to talk about. The time just flew by as we covered a number of topics, and we talked so much that I decided to split the interview into two parts! Both episodes drop today, so bonus! There's more to come with Mr. Elden and you won't be disappointed. Thanks for talking with me, Justin, and thanks for listening, everyone! The show email is somuchpingle@gmail.com, and there’s also a So Much Pingle group on Facebook, for discussion, comments, feedback, suggestions, trainspotting, scary bear stories, herp confessions, tips for herping better, etc. Stay tuned for more episodes! And don’t forget to herp better! -Mike
Aggravating Circumstances Season One Episode Fourteen. The continuing story of the wrongful conviction of Destry McKinney. Season One of Aggravating Circumstances tells the story of Destry Cord McKinney a musician, studio producer, combat medic and father. It's a tale of hidden evidence, unintended consequences and a wrongful conviction. This is a continuing story so be sure to start with episode one. See more at AggravatingCircumstances.com Episode Fourteen includes an interview with attorney and sports' journalist Craig Calcaterra. Check out Craig's website CraigCalcaterra.com and his daily baseball reporting at cupofcoffee.substack.com
Episode Fourteen features Paula Crown, a multimedia artist with a practice encompassing drawing, painting, video, and sculpture. She incorporates cutting-edge technology, social activism, collaboration, and a commitment to sustainability in her studio practice. Crown has had several solo exhibitions including the Aspen Institute, Dallas Contemporary, Marlborough Gallery, New York, Venice concurrent with the 16th Venice Architectural Biennale, and Fort Gansevoort, New York, to name a few. She has also participated in various group exhibitions nationally, including For Freedoms, Jack Shainman Gallery, New York, Mount Analogue, Aspen, and the Elmhurst Museum of Art, Illinois. Crown's Public Art Installations include being featured during EXPO Chicago 2014, the Miami Design District several years and Thoughts & Prayers, with For Freedoms, Chicago in 2018. Most recently, she had a public art installation at the For Freedoms Congress in LA (2020). In 2009, President Barack Obama appointed Paula to the President’s Committee on the Arts and the Humanities. She is a trustee of the Museum of Modern Art and serves on the Aspen Institute Committee of the Arts. Upcoming projects in 2020 include large-scale installations in the United States, the United Kingdom, and India. Crown's works are in numerous public and top-100 private collections. Please read more about Paula Crown in links provided below. https://www.atelierpaulacrown.com/ https://www.aspenideas.org/speakers/paula-crown https://www.galeriemagazine.com/paula-crown-venice-dallas-contemporary/ https://hauteliving.com/2014/03/paula-crown-shares-journey-wall-street-art-world/457891/ https://forfreedoms.org/partners/for-freedoms/
Episode Fourteen of the Punk Rock Classrooms Podcast! "Getting Through the Pit!" We all have struggles with our role in education. Maybe it one piece of your curriculum you dread, maybe its discipline that takes you away from being an instructional leader, maybe its the reports, or maybe its being away from your classroom during a global pandemic. If punk rock taught us anything its that sometimes you have to fight through the pit to get to the stage. There are tough parts that we need to make the most of so we can get to the root of what we do as educators, working with students to help them succeed. So let's work together to get through the pit so we can enjoy the show. Twitter twitter.com/punkclassrooms twitter.com/educhefearnshaw twitter.com/JoshRBuckley Intro music - "I'm Against It" by The Ramones Outro music - "It Can't Hurt" by The Mighty Mighty Bosstones Check out our PRC Playlist here for all of the rad tunes we use: https://bit.ly/PRCPlaylist
Clone traitors, pacifists, and lots of moral gray area?! This Clone Wars business is getting serious! We continue our viewing of The Clone Wars Season One as we tackle episode 13-16. We have four hosts for the duration this week, there are some weird diversions as usual and Rocky tries to smoke and talk at the same time! Turn up your headphones, dial back your sensibilities, and join the wretched hive of scum and villainy as we take the low road to resistance on Episode Fourteen of Force Insensitive!Send Email/Voicemail: mailto:forceinsensitive@gmail.comStart your own podcast: https://www.buzzsprout.com/?referrer_id=386Use our Amazon link: http://amzn.to/2CTdZzKFB Group: https://www.facebook.com/groups/ForceInsensitive/Twitter: http://twitter.com/ForceNSensitiveFacebook: http://facebook.com/ForceInsensitiveInstagram: http://instagram.com/ForceInsensitive
Bringing you a poetic Greek tragedy/romance short story for Valentine's Day. I hope this stand-alone romance can sate your appetite for a good audio performance. A man experiences heaven and then must realize the cold absence of this heaven. This is Episode Fourteen, Calypso - 칼립소
We've got a big episode this time around with all sorts of topics big and small! Episode Fourteen of Taking It Down is here! Adam Morrow joins in for a talk about some quick thoughts on the Golden Globes and the results of the first of the big award shows (2:02) and then they take a deeper dive into the first four episodes of the new Netflix show Messiah (8:37). After the break, Blaine is joined by Donovan Reinwald; they talk about the new movies Little Women (39:06) and Uncut Gems (48:20). You may wish to note that the section of today's podcast on the Adam Sandler movie Uncut Gems barely treads into spoiler territory, but it may spoil just enough that you may want to wait until you see the film before listening. Give us a shout and let us know what you think about Messiah, Little Women, or Uncut Gems!
How do you validate your idea for a new business? We find out in Episode 14 of the Planetary Potential! The Planetary Potential is hosted by Andrew P. Rowan and is recorded on location. This is Episode Fourteen of Season One which features 20 episodes with a common theme of Peru. For a transcript of this episode, head over to https://andrewprowan.com/episode-14-of-the-planetary-potential-with-alicia-vivanco. For exclusive bonus content, including extended versions of this and other interviews, head over to https://www.patreon.com/planetarypotential --- Send in a voice message: https://anchor.fm/planetary-potential/message
Welcome to Episode Fourteen of Apocalypse. A Strange Pleasures Radio Lab production, written and narrated by Robert KnightAMAZON AUTHOR PAGE https://www.amazon.co.uk/Robert-Knight/e/B07WH3QCML/ref=dpbylinecontpopebooks_1HOME WEBSITE https://apocalypse-a-strange-pleasures.pinecast.co/STITCHER https://www.stitcher.com/s?fid=474043&refid=stprLUMINARY https://luminarypodcasts.com/listen/robert-knight/apocalypse-a-strange-pleasures-radio-lab-production/7531c80b-c2a2-4e19-b716-cffa3c9a41c9SPOTIFY https://open.spotify.com/show/0Nho9kQE1zhfsgVN5rwWPEITUNES https://podcasts.apple.com/gb/podcast/apocalypse-a-strange-pleasures-radio-lab-production/id1483662157Twitter: @LabStrangeSupport Apocalypse: A Strange Pleasures Radio Lab production by donating to their Tip Jar: https://tips.pinecast.com/jar/apocalypse-a-strange-pleasuresFind out more at https://apocalypse-a-strange-pleasures.pinecast.coThis podcast is powered by Pinecast.
An email from the desk of Cinesthesia host Jason Michelitch: "Episode Fourteen is uploading. It's a big rambly one, about the 1990 TV movie IT, but also about my weird theories about epicenters of cultural events and also a lot about the book IT, and I am afraid it is our most boring episode yet but I don't really have time tomorrow to do more aggressive editing on it. So it is as proportionately long and clumsy as the 1990 IT." Join a filmmaker (and sometimes film teacher) and a film teacher (and sometimes filmmaker) as they venture into the dark heart of their own befuddled relationship to culture, the youth, the internet, friendship, love, hate, time, space and, of course: *m*o*v*i*e*s*. Come hear what we see.
Welcome to the Baseball Together Podcast, baseball family! Brig is out for one more week while Brad is joined by another guest co-host, Quinn (previously mentioned in Episode Fourteen). In this wee's episode they talk about a change in leadership with the Boston Red Sox (0:51), the Christian Yelich injury (5:21), and Seattle's Kyle Lewis (12:20). If your team has been (or will be) eliminated from postseason contention, they try to help you find a contender to cheer for by going team shopping (21:49).9PlusUs.comEpisode Page
Liz (Squishy) Houchin wrote in via the Writers Drinking Coffee FB page asking about muses. John and Jeannie sound off on the topic of muses they've seduced and left sated in their wake. … Continue...Episode Fourteen – Those Tricksy Muses
"London and haunted houses and colored pencils, oh my!" Episode FOURTEEN goes every which way, from Flamingo's travels in Europe (she's back!) to Grant's morning routine with colored pencils, all the way to Sean's experience at a legitimate haunted house, BIG NEWS *small towns*, and a potential new segment involving TWITTER. Join us for a jam-packed episode that you're sure to leave encouraged. Join us, and BE ENCOURAGED!Got a fun question, a comment, concern, or just want Grant's advice on a personal issue? Drop us a voicemail or send a text to 405-265-6706. Please understand that by submitting anything you are allowing potential use on the podcast.Email us: werejustpeoplepodcast@gmail.comSupport us on Patreon: https://www.patreon.com/werejustpeopleSupport the show (https://www.patreon.com/werejustpeople)
Welcome to Episode Fourteen of Strange Pleasures Radio Lab. Your daily audio story podcast available through iTunes, Spotify and YouTube.Each day I will narrate a well known story in it's entirety. As a writer I will also include some narration of my own books that can be purchased through the Amazon Kindle Store, or through the Amazon Prime Kindle Unlimited subscription program.Today I will be narrating Ulalume by Edgar Allan Poe.YOUTUBE: https://www.youtube.com/channel/UC8MoqBN8-vdAsaoYBZX32OA?viewas=subscriber?subconfirmation=1HOME WEBSITE https://strange-pleasures-radiolab.pinecast.co/SPOTIFY https://open.spotify.com/show/6x2VOcohjOKeJ8ZIJpvi8rAMAZON AUTHOR PAGE https://www.amazon.co.uk/Robert-Knight/e/B07WH3QCML/ref=dpbylinecontpopebooks_1ITUNES https://podcasts.apple.com/gb/podcast/strange-pleasures-radiolab/id1476208251STRANGE PLEASURES VIDEO LAB: https://youtu.be/9gwuSXroVvkSupport Strange Pleasures Radiolab by donating to the tip jar: https://tips.pinecast.com/jar/strange-pleasures-radiolabFind out more at https://strange-pleasures-radiolab.pinecast.coThis podcast is powered by Pinecast.
Hello, Episode Fourteen is missing. We don't know where it is. It's gone. For the time being we will continue releasing episodes on schedule. We hope Episode Fourteen does turn up. It would be a shame if it were to fall in the wrong hands.... In this episode, Lauren recovers from a concussion, and the gang hangout at the arcade where an exciting, brand new cabinet is unveiled. COMMANDROIDS: A WORLD TRANSFORMED! If you would like to support Commandroids on Kickstarter you can learn more by searching "Commandroids" on Kickstarter or visiting this link: http://kck.st/338NbZU
Welcome to Episode Fourteen! Today we discuss becoming the best possible version of you! Things you did a year ago 6 months ago even a month ago might not work for you now because you could have evolved into the next level of yourself. Keep an eye out for the next thing that you can do to change your daily, weekly & monthly actions and just transforming it into something that will work for you specifically. it's something that you're going to always be working on; it's never going to be perfect but there is some joy in knowing that you'll never be stuck. There always be something that you can do to help become the absolute best version of yourself. I hope you enjoy this weeks episode! ----more---- Let's connect on IG Www.instagram.com/richelleethomson
It's the moment everyone's been waiting for: a new opening and ending! Midoriya and All Might have a clandestine encounter and All Might calls someone a man child. Oh, and Ochako has a mental break! Be sure to follow us on twitter @MyHeroNotebook
EPISODE FOURTEEN! AMAZING!This week comedian, writer and general vaper, Ahir Shah joins Beth and Helen to discuss crying, dressing and smoking (which we would never recommend, but feel free to make up your own mind...)Follow Ahir on Twitter right here! https://twitter.com/AhirShah..............................................................................Follow the show on Twitter https://twitter.com/rulesforlifepod and Instagram www.instagram.com/rulesforlifepodBeth on Twitter https://twitter.com/beth_rylance and instagram www.instagram.com/thebethrylance Helen on Twitter and instagram https://twitter.com/HelenSimmons8 www.instagram.com/helensimmons8 Edited and produced by the brilliant Eliot Fallows https://twitter.com/EliotJFallows See acast.com/privacy for privacy and opt-out information.
Episode Fourteen of the kind of wrestling adjacent podcast by the high flying death defying luchador Lucha DS Officially sponsored by Masked Republic Follow Lucha DS on social media Facebook https://en-gb.facebook.com/luchaDS/ Twitter https://twitter.com/luchads?lang=en Instagram https://www.instagram.com/luchads/?hl=en YouTube https://www.youtube.com/channel/UC5FVmhw5098RETSkKmcOCsg
Don’t forget RM loves, Episode Fourteen is split into two parts. In Part Two, we cover the last three segments. Karlin tells us about Leo Koury, a very dangerous restauranteur who ended up on the FBI’s 10 Most Wanted list. Alison falls into the rabbit hole that is the sad tale of Michaela Joy Garecht and we get truly grossed out by the suspects in her abduction. Eliza has her first haunting and the ladies can't seem to agree on this one. Guess which one of us still isn’t convinced... If you know anything about Michaela or her kidnapper, you can contact investigators at 1-800-222-3999. If you have any information concerning this person, please contact your local FBI office or the nearest American Embassy or Consulate. You can remain anonymous. Get exclusive and early access to Short Stacks on Patreon:https://www.patreon.com/resolvedmysteriespodcast Support us: https://resolvedmysteriespodcast.com/advertising-support Oooooh get that sweeeeeeeet RM merch, honeys! https://resolvedmysteriespodcast.com/merch Follow us! IG @re_solvedmysteries Facebook @resolvethepodTwitter @resolvethepod Have a favorite unsolved mystery of your own? Contact us! resolvedmysteriespodcast@gmail.com Music by Sam Cooper: samcoopermusic.comLogo Design by @rachellenidrasomma This week's promo! Let's Talk OC :https://letstalkoc.simplecast.fm@letstalkoc on Twitter + Instagram Learn more about your ad choices. Visit megaphone.fm/adchoices
Join Sean Baligian and Kevin Troczynski for Episode Fourteen of the State Champs! High School Hockey Report presented by the Michigan High School Hockey Coaches Association and it's also brought to you by National Coney Island and the MHSAA.
Because Joe couldn’t join us for Episode Thirteen, we felt like we should give him the glory of hosting Episode Fourteen, THE JOE SHOW!!! In Episode Fourteen of the "Look Out, Sir! 40k" Podcast “THE JOE SHOW!!!” we discuss the following topics: 11:01 - Section 1: We kick things off by discussing elements of the new Genestealer Cult Codex. This is predominately us trying to understand how the new Cult Ambush Blip system works, but there’s some other stuff in there as well. Don’t expect it to be the best insight into the GSC Codex though, if you’re looking for that there are many more places to go check out. However, we hope you enjoy what we have to say regardless. 50:05 - Section 2: Joe wanted us to talk about Dice for some reason. None of were sure why until he explained it to us while we recorded. Regardless if it’s any good or not this is the Joe Show! And on the Joe Show, we talk about the stuff Joe wants to talk about. So come with us now on a journey through time and space, as we explore the mysteries of Joe’s mind and what he thinks about Dice. 01:12:59 - Section 3: This was supposed to be us talking about the 40k models revealed at the LVO. However, Joe changed his mind and we talked about the Brawlentines Day Massacre 40k Tournament which Dan, Joe, Phil, Richie and Tim played in. Though Richie isn’t in this section of the show, or any section for that matter. Dan, Joe, Phil and Tim talk about how they got on at this tournament hosted within Entoyment Poole. 01:49:23 - Section 4: We ramble on about the new and or upcoming 40k models showcased during the Las Vegas Open. That’s the new Chaos Space Marine Black Legion Stuff as well as the new Primaris Vanguard Space Marines. Note we do not overly discuss the new Abaddon teaser if at all. We're waiting till we get to see him before talking about that in any detail. :) Additional Description Stuff:If you would like to know more about future events from 40k Brawl Events, please check out their Facebook page: https://www.facebook.com/40kbrawlevents/If the above Facebook Page doesn’t give you enough to work with you could also consider visiting Entoyment’s website: https://entoyment.co.uk/No one is paying us to put that here we just thought it was an ace event and you should check it out if you can. Most of us will be at their next event in April and it would be great to see you there! Thanks very much for taking the time to listen and by extension support our podcast. We hugely appreciate it and hope that you enjoy what we have to say on all the various 40k and or Games Workshop related things!
In this week’s episode of COSMOS AND THE CITY: THE SEX AND THE CITY PODCAST, your host Megan McIver will sit down with her very own Mr. Big aka Terence Deutsch. Together these two will discuss Season Three, Episode Fourteen of SEX AND THE CITY entitled: “Sex and Another City”This week Megan & Terence will be talking through: Samantha Fake Fendi Fiasco, Charlotte leaving her marital problems behind (back on the east coast), Miranda letting go of her NYC Stress, and Carrie finding herself a tall drink of water, in the form of Vince Vaughn.Plus we’ll have all your favorite segments: Hottie of the Week, Pun of the Week, Good Big Bad Big, Who Wore What Why?, and You’re Such a _________.Will Samantha be exposed? With Charlotte’s problems melt away in the LA sun? Will Miranda learn to love the Best Coast? Will Carrie find a reason to give LA a try? Through all the craziness Megan & Terence will share their thoughts on ABSO-FUCKING-LUTELY EVERYTHING.EPISODE SYNOPSIS: “Still away from New York, the girls embark on week two of their Los Angeles adventure. Hoping to get away from the happy superficiality of LA and reconnect with her neurotic roots, Miranda gets together with Lou, an old New York friend. But instead of trashing LA as Miranda hoped, Lou says the city has taught him to let go of his toxic anger. Meanwhile, Carrie and Samantha try to live the quintessential LA. scene by going to a movie screening party - but they're rejected at the door. Luckily, Carrie meets Keith, who gets them into the party. Wowed by Keith's status, Carrie goes on a date with him and ends up in bed at his fabulous home...until Keith's boss comes in the house and lets the cat out of the bag -- Keith isn't a television mogul; he's a personal assistant. Back home, after another failed attempt to have sex with Trey, Charlotte decides she misses her friends and hops on a plane to LA. Over lunch, Charlotte breaks the news that her marriage is fake, and they're not having sex -- the girls are stunned. And in a last ditch effort to be LA women, the girls all head to Hugh Hefner's Playboy mansion for a pool party. Charlotte meets a charming older man, who offers to buy her a boob job, and Samantha gets them all kicked out for accusing one of the bunnies of stealing her fake Fendi bag.”Thanks for listening! If you wanna support our show by shopping on Amazon, use our link.Our Host: Megan McIver• Twitter• Instagram• FacebookOur Guest: Terence Deutsch• InstagramWhat We Watched:• Sex and the City Season Three Episode FourteenCosmos And The City Social Media• Instagram • Facebook• Twitter• WebsiteMusic by Jon Fredette •
Episode Fourteen of Ms. Demeanor & Ms. Conduct. A bi-weekly, light hearted look at all things mysterious in Canada. Tales of murder, mystery, conspiracy, cults & much more. This week, a raspy voiced Kennedy shares two stories. The trial of Angelina Napolitano, the first ever woman in Canada to use the “battered wife” defense and then Saskatchewan's oldest cold case, The Woman in the Well. After that, Jena brings it home with the detailed account of Canadas “Vampire Rapist,” Wayne Boden.
Episode Fourteen. From Rodeax, the company that bought you Tales from Wytch Haven and In The Frame: The Film Review Podcast, now brings you; The CLASSIFIED Transmissions. A short 24 episode series. The Cronos Star liner has become over run with a deadly being known as the krill. Follow one mechanic's mission as he tried to save himself and anyone else that hasn't been met with the slaughter the krill bring with them. Created by Dan Lee & Rodeo Whiter Voiced by Dan Lee & Rodeo Whiter Introducing Phill Boobyer Produced by Rodeax Ltd.
In this week’s episode of COSMOS AND THE CITY: THE SEX AND THE CITY PODCAST, your host Megan McIver will sit down with the fantastic Eileen Mary O’Connell. Together these two will discuss Season Two, Episode Fourteen of SEX AND THE CITY entitled: “The F… Buddy”This week Megan & Eileen will be sorting through: Samantha getting turned on by the sounds of the couple next door, Miranda and hooking up with a bossy work colleague, Charlotte juggling multiple dates and Carrie trying to turn her fuck buddy into a relationship.Plus we’ll have all your favorite segments: Hottie of the Week, Pun of the Week, Good Big Bad Big, Who Wore What Why?, and finally You’re Such a _________.Will Samantha take the long walk to the next apartment? Will Miranda continue to take the abuse? Will Charlotte be able to handle many men in her life? Will Carrie make things work with her fuck buddy? Through all the madness Megan and Eileen will share their thoughts on ABSO-FUCKING-LUTELY EVERYTHING.EPISODE SYNOPSIS: “Carrie meets Miranda's ex Skipper, a sweet guy who is getting desperate as all women seem to turn him down in favor of jerks - like Kevin, the bossy colleague Miranda is dating right then. When she confesses this to her friends, this contradiction bugs her too. Samantha declares monogamy fits none of them, as its high expectations are never met. To everyone's surprise, Charlotte takes that advice to the extreme, double-dating two fine men - till they find out and walk out on her together. After a few lonely weeks without Big, Carrie invites John, her dependable rebound-lover just-for-sex who always repairs her self-esteem, and wonders why she never tried committing to him, so the next time they actually go out for dinner, which only proves their conversation is as uninspiring as their sex is enjoyable; the following movie is their last date ever.”Thanks for listening! If you wanna support our show by shopping on Amazon, use our link.Our Host: Megan McIver• Twitter• Instagram• FacebookOur Guest: Eileen Mary O’Connell• Instagram• Twitter• Skeeter-ial Podcast• WebsiteWhat We Watched:• Sex and the City Season Two Episode FourteenCosmos And The City Social Media• Instagram • Facebook• Twitter• WebsiteMusic by Jon Fredette •
Episode Fourteen! Natasha munches an avocado burger of animal anecdotes Katie investigates international intrigue And George is just dirty.
On the programme this week is the architect Annalie Riches – one half of the multi-award winning architecture firm Mikhail Riches. The practice, founded by Annalie and her partner David Mikhail – are known for their considerable track record of beautifully considered housing developments. Annalie originally studied architecture at Sheffield University before moving to Paris … Continue reading "Annalie Riches – Episode Fourteen"
Episode Fourteen features guest Disco Dracula back again(so soon) with new-timer Mr. SkellyBones, and host Captain Death, where they discuss shows, their love of weeb and videogame shit, and some spoopy spoopos. First 2 guest episode of several to comeSammy(10:17)Silence(15:38)Diary of a Fat Girl(22:07)The Tape(28:26)Nightmares(30:59)Art Warehouse(34:14)A Skeleton Popped Out(38:09)The Lost Game(39:05)666º BloodBoarding(39:56)Dollhouse(43:41)House of Mirrors(44:32)The Terrible Bastard of Death(46:05)CHECK THE YOUTUBE for EPs! SUBSCRIBE @https://www.youtube.com/channel/UCxoqIN-fkfdlmGEjWujypxwFeaturing wonderful ambient music from our fam in Sweden: CryoChamber, givin' us all the ooky-spooky tunage. Follow: @cryo-chamberThank you!"Are You Afraid of the Dark Theme Song," "Spooky Skeletons REMIX," and "You Reposted in the Wrong Neighborhood" are not my songs. Credit and All rights are reserved by the owners
Episode Fourteen of Chiowa features the Michael's discussing the Cleveland Indians INSANE winning streak - how does it compare to other win streaks? The guys are back with the South Side Second, college football was great (yet again), and the Patriots are done (not really). Bodybag Brenner is back with his picks for NFL week 2, as well as an analysis of last week's picks (hint: we won and now we're rich). Listen to his picks and you'll make money, he guarantees it! Bear and Cub Talk rounds out the show before Olsdog's SOTW.
Episode Fourteen of Womankind welcomes Kate Sanetra-Butler and Kim Spelman of Dignity Matters, a Massachusetts-based non-profit organization that collects feminine sanitary products and undergarments for women who are homeless and in need. Listen to discover ways that you can contribute to Dignity Matters’ mission in your own community!
Episode Fourteen of IdeaPod. In this episode, Rob and Michelle throw brands and ideas at the wall and see what sticks. Read More The post #14 Clash of Brands appeared first on Bandwidth Marketing.
Keeping Time With Jeremy Oster & Daniel Robbins, Episode Fourteen, features the Gronefeld brothers, owners of Gronefeld watches. Tim and his Brother Bart were born into a family tradition of jewelers which spurred their passion for watchmaking. The brothers studied at some of the finest horological schools in the world and went on to gain experience from some very prestigious watch brands before creating their own company. Join us as we get insight into Gronefeld, and the passion behind the brother's tremendous success. Keeping Time With Oster Watches is a podcast dedicated to enriching conversation about the luxury watch industry.
Episode Fourteen! Lesa's been fighting with her friends on social media. We talk about politics, religion, racism, The Jets and Selena. Please take 5 seconds to rate or review the podcast on itunes and if you like it subscribe! Thanks for listening! LINKS Felipe Esparza: FACEBOOK: www.Facebook.com/FelipeEsparzaFanPage TWITTER: @FunnyFelipe INSTAGRAM: @FelipeEsparzaComedian www.felipesworld.com Lesa Esparza TWITTER: @LesaInLA INSTAGRAM: @LesaInLA
This is Episode Fourteen of the Hairy London Novel Podcast
Episode Fourteen. The denizens of Deadwood are on edge following the day's earlier ruckuses and rumpuses. Fortunately, Nuchtchas returns to help us make sense of the various complexities that weigh so heavily on Al Swearengen's mind. Charlie suffers from an array of distracting maladies... Alma bears the burden of an immense decision... Hawkeye's selfless acts go unappreciated... Wu's pigs contract insightfulitis... Our Carol lets loose her Slippery Dan hate. ... Also, Alirio introduces us to "Uncle Billy" and announces a footrace between local heavyweights. | Send feedback to hooplecast@gmail.com. Find our recording schedule, show notes, discussion threads, and more at hooplecast.com. | Recorded August 16, 2015. Released August 22, 2015. [Warning: Explicit Language.]
![[BLANK] IS EMOTIONAL](https://ivyfm.s3.amazonaws.com/i320/675080.jpg)
Episode Fourteen. matthew discusses his harrowing time at taco bell during jury duty, max sings a brand new song inspired by "kokomo" by the beach boys, malkmus celebrates his SIXTH birthday (WOW! -- HOW MANY YEARS IS THAT IN HUMAN YEARS???!), and all three watch the trailer for "biodome" in celebration of its 20th anniversary!
Join comedians Rachel Fairburn and Kiri Pritchard - McLean as they explore a shared passion, serial killers. Each episode the pair will talk all things murder and macabre and have a right laugh doing it. Episode Fourteen looks at Nikolai Dzhumagaliev, Metal Fang. He's got a badass nickname and a habit of eating women. Short one this as it turns out that the then Soviet Countries like to keep this kind of thing quiet...
EPISODE FOURTEEN. MONTEZUMA’S REVENGE! WELCOME to a BUMPER slab of the Brothers Nash’s adventures with antiques lothario and 80s/90s Sunday evening TV great “LOVEJOY”. JOIN US as we delve deep into Episode 14… With Inca curses, a blow-dart murder mystery, rock idiots, mullet-blowing, Ian McShane romancing a Columbian lady, Lady Jane romancing Lovejoy, and tales from […]
Nell's reunion with the group is short-lived when a surprise attack causes their escape plan to backfire. Salem and Elliot are accidentally separated, and Nell, Iris. and Amelia reluctantly escape. As Nell and Iris reveal the origins of the Aurelius to their studious comrade, Amelia, an unexpected yet unfortunate truth awaits these five unsung heroes.
Multiple Sclerosis Discovery: The Podcast of the MS Discovery Forum
[intro music] Host – Dan Keller Hello, and welcome to Episode Fourteen of Multiple Sclerosis Discovery, the podcast of the MS Discovery Forum. I’m your host, Dan Keller. This week’s podcast features part two of an interview with Professor Gavin Giovannoni about the role of Epstein-Barr virus in MS. But to begin, here is a brief summary of some of the latest developments on the MS Discovery Forum at msdiscovery.org. We've published a blog post from Christine Granfield, the founder of HealthCare Journey. Healthcarejourney.org is a website designed to help MS patients easily navigate the expanse of information about MS. In the blog post, Ms. Granfield says that HealthCare Journey is not meant to replace the doctor-patient relationship but instead provide a place where patients can find answers to questions with accurate, up-to-date information when their physician might not be available. We published another blog post written by our intern, Cynthia McKelvey, on how to interact with the news media. News about science is often sensationalized and over simplified. But that’s all the more reason for researchers and clinicians to be media-friendly. In her post, Cynthia offers 13 tips on how to talk to reporters so you can be sure the best and most accurate information gets to the public. Last week we interviewed Dr. Alan Thompson of the International Progressive MS Alliance about the difficulties of researching progressive MS. We published more information on the Alliance, its goals, and a full list of the 22 recipients for their first round of funding, totaling 22 million euros. To view the article, visit msdiscovery.org and visit our News Briefs section under the News and Future Directions tab. [transition music] Now to the interview. Professor Gavin Giovannoni from Queen Mary University in London is one of the worlds most prolific and most visible MS researchers and clinicians. He's also on the scientific advisory board for MSDF. Two weeks ago we featured the first part of my interview with him about the potential for a cure in MS. This week we’re going to discuss the roll of EBV in MS. Interviewer – Dan Keller Professor Giovannoni, where does it come in? How has it entered the thinking? Interviewee – Gavin Giovannoni We have a causal theory. We don't just switch on a light switch, and we've got a call that said it evolves over time. And if there's one particular thing that looks like it's got the top candidate for being a cause of MS is Epstein-Barr virus. And I think the original observation is epidemiological. People with infectious mononucleosis, which is delayed EBV infection that is symptomatic, have a higher risk of developing MS, and that's been reproduced now across many, many studies as a risk factor. But EBV infection in itself is a risk factor because if you're not infected with the virus, in other words people who don't have the virus, have a very, very low risk…it's almost a zero risk of getting the disease. So in terms of its negative predictive value – that's the strongest value we have – people don't get MS if they don't have EBV. So it looks like it’s an essential component of the causal pathway. How it's acting in the causal pathway? We don't have any idea. We just do know that if you do get EBV infection or infectious mono it's a risk factor throughout life. So in the Danish study, it shows the risk remains even when you go into your 40s, 50s, and 60s, which is interesting. And EBV is a complex biology. We don't know where it's acting. We know it resides as a latent infection in the B cell. And what it's doing to B-cell biology is incredibly complicated. It hijacks B-cell biology, and it affects its antigen-presenting function, it affects its survival, etc. So people are targeting the B cell; I think the B cell is important. And the reason why I think the B cell is important when you look at all the most effective therapies in MS, when you put them on a chart with all the cells they affect, the only common cell to all of them is the B cell. And the link that the B cell may be the Epstein-Barr virus. And how EBV triggers autoimmunity haven't a clue. We originally thought well maybe the link between infectious mono and MS was related to HLA susceptibility. But we did a study on university students in the UK, and we showed that the HLA type that predisposes you to infectious mono is not the HLA type that predisposes you to MS. So we don't think it's at the HLA level that EBV is interacting with MS susceptibility; it's somewhere else. The other risk factors are smoking. And when you start putting smoking and EBV and low vitamin D, which is the other environmental factor, together it looks like there's some interaction of all three components. But how they're working at a biological level that's where research needs to be done. So some people are … I think there's mimicry between EBV and myelin proteins, and there is some data that there are some antigenic epitopes in the EBV proteins and [?] antigens, which is why a lot of people are focused on CD4 cells as being the link. I'm not sure if it is the CD4. Others are focused on the CD8 cells as being the link. Michael Pender in Brisbane, Australia, thinks that Epstein-Barr virus is acting as the innate stimulus, the danger signal, that just upregulates innate immunity that then allows autoimmune responses to occur on top of that. And he thinks that's occurring in the central nervous system. That's his theory. And he thinks that people with multiple sclerosis have a deficiency of cytotoxic CD8 cells that keep the EBV virus in check. So he's now testing the strategy of trying to boost the CD8 response against EBV and kill the Epstein-Barr virus to lower the innate activation and reduce autoimmunity. That's his theory. I wish I could tell him my theory. All I know is that the epidemiological observations are pretty standing. And you know, we probably should be doing a vaccine trial to test the hypothesis. There is a vaccine for EBV, but it's been discontinued. So GSK developed the vaccine. It wasn't that effective in stopping EBV infection, but it was very effective in preventing infectious mono. So what it did was it raised your immunity to a level that stopped you getting infectious mono, and that may be enough for MS prevention. You know, when they sold the EBV vaccine program to MedImmune, and I heard about six months ago that maybe they had stopped the program. There is no EBV vaccine program occurring in the pharmaceutical arena. There's been a recent meeting in Oxford around Epstein's anniversary because it's 50 years since he discovered the virus. And the, Harold Varmus was there, and there's a big push now for the NIH to fund a vaccine study – interesting not to prevent MS but to prevent the secondary malignancies linked to EBV. Because EBV is linked to a whole lot of hematological malignancies. So the idea there would be if you could prevent people getting Epstein-Barr you prevent a whole lot of lymphomas particularly. I'm personally a little worried about that strategy because EBV is one of our most co-evolved viruses. At a population level, it's part of our immune systems. So I actually think at a population level EBV must be doing something good for society and the population. I think it may be a link to B-cell memory or something like that. So if we stop people getting EBV, we may be storing our problems at a population level. But until we do the trials we won't know. So we need a vaccine, and that's the way to test is EBV causal? Coming away from it, it may just be the trigger, or it may be driving the disease continuous. If that's the case, then we need to have anti-EBV drugs. And there is one being tried right now; it's called ocrelizumab. It's an anti-CD20 drug. Itself hasn't been tested as an anti-EBV drug, its predecessor, which is rituximab, is licensed as an anti-EBV. It's actually the only drug that's licensed to treat EBV. It's licensed to treat EBV associated lymphoproliferative disease, which occurs in transplant patients. It's pretty effective at switching off on that condition, and the EBV levels just plummet. A company that's developing ocrelizumab, which is Genentech Roche, wouldn’t like for me to say that it's an anti-EBV drug, but that's exactly how it may be working in MS; it may be targeting EBV. The obvious thing is to test antivirals that target EBV. There are no specific ones that have been designed for EBV, but we've got a particular drug that we would love to test against EBV because it has some activity. Trying to get the funders convinced that we should do a trial of an anti-EBV drug in MS has been difficult. I think we shouldn't ignore the EBV hypothesis, though, because the data out there is pretty compelling that it's causal. And as a community, I think we have a responsibility to test whether or not it is causal. And the only way we can do that is intervention studies – vaccines and targeting the virus with antibiotics. MSDF It seems the geographic distribution of MS may actually be opposite say the distribution of Burkitt’s lymphoma. And what is EBV doing and how does it do it in different regions? And I wonder if that brings in the vitamin D hypothesis again. Dr. Giovannoni MS prevalence pretty much matches infectious mono prevalence. So infectious mono has also got a gradient. The Burkitt's lymphoma thing probably that follows patterns of parasitic infection, particularly in malaria. So I think EBV probably interacts with other infectious agents, and that's one of the theories about EBV; it's not working on its own; it's working as a coinfection with another virus. The other virus that we need to talk about are the family of the HERVs, human endogenous retroviruses. Because the EBV is a potent transactivator of these viruses. In the big body of literature on HERVs being involved in MS, a lot of us think it's associative. In other words, inflammatory response triggers transactivation of HERVs in what we see as an epiphenomenon. But there are people who think it may be linked to the cause of the disease. Again the only way we can test this hypothesis is by treating people with drugs that target EBV and HERVs. Because HERVs are drugable; they are retroviruses, and you've got a whole arsenal of therapy that could target the various components of HERV biology. We should be doing trials in that as well. Coming back to the vitamin D, there has been one small study that needs to be reproduced showing that if you do get EBV infection when your vitamin D levels are low your antibody responses are much more marked. And so there may be some link between low vitamin D and infection, but nobody has actually studied that formally, and I think it's something we tried to do with our epidemiological tools to see vitamin D deficiency or low levels makes it more likely that you're going to get infectious mono, that maybe they are interacting with each other. I don't think it's going to be as simple as that, though, to be honest with you. I think they're probably going to be working in an immunological level. I'm not sure if they're going to be causal; I think they may be associated with each other. EBV triggers a mess of lymphoid proliferation, which consumes vitamin D levels. So if you find someone with infectious mono and they have low D levels, it could be the infectious mono is reverse causation rather than the other way of causation. So we need to do that prospectively, and it's a difficult study to do. But I think also the other thing you've got to look at is when they're starting to put all of these risk factors together in studies, and this has been mainly been done in the Scandinavian databases – and you start putting the HLA-DR15 in, the protective HLA-A2 in, the history of infectious mono, serum levels of anti-EBV antibodies, put smoking in, start putting vitamin D levels in – you're beginning to see relative up about 40. So that's a big signal to me because the doyen of causation theory, Bradford Hill, said that when you start getting relative risks above 40 that you should be thinking causation. So I'm beginning to see a causal pathway where all of these factors now are giving relative risks that are very high compared to the background population. And so, those factors must all be in the causal pathway. And the question is which one can you intervene in? And there's a few you can intervene in. But EBV is the obvious one. If you take it out of the causal pathway, you may be able to prevent this disease. So I'm lobbying – and whole lot of us are lobbying – that we really need to get the public health community and the MS community and the virology community together so we can start thinking about prevention trials. Around about 5 to 10% of the adult population are EBV negative. But that group of people don't get MS. So that's the important factor is those people don’t get MS. MSDF But the flip side is 90% of the population has been exposed to EBV, and most of those people don't get MS. So do you think it's all of these other cofactors you've mentioned? Whereas EBV sort of lights the fire if the fuel is there? Dr. Giovannoni Yes, I think that's true. And Bradford Hill, I mean he developed his theory for causation around common manifestations or re-exposures. Like asbestosis is one of the examples he always used that if you had asbestosis, which is quite of a rare exposure, the chances of getting mesothelioma, which is a rare cancer, was almost 200 times background. So that's easy to understand. But EBV is such a common exposure, and MS is a relatively rare manifestation. So in that situation, the relative risks come down. So even though the relative risk of getting MS is only about 2.2 to 2.5 with infectious mono, it doesn't mean to say it's not causal. It could still be causal. So I'm not worried that the relative risks are low. But I agree with if it's EBV infection on top of something else the genetic susceptibility, the low vitamin D, or all those other factors that then triggers the autoimmune response. But if EBV is a pivotal factor and you stop it, those other factors are irrelevant. That's why we need to do prevention studies. We need the vaccine, though. The original vaccine strategy was developed to prevent EBV completely; that's in terms of oncoprevention. But in terms of MS and autoimmunity, you may not have to prevent Epstein-Barr virus. Maybe what you need is to make sure you're vitamin D replete and get wild-type infection when you're very young. That may be sufficient to lower the risk of MS. You may not necessarily need a lifelong protective immunity against Epstein-Barr, but maybe you just need to be infected at a young age when your immune system can deal with it. It doesn't fertilize the field for autoimmunity later on in life; that may be the strategy. MSDF Does it get into the possibility of tolerance? Dr. Giovannoni Yes. MSDF To EBV? Dr. Giovannoni If we knew about the biology of EBV, I mean I'm not a virologist. And when I delve into the complex biology of Epstein-Barr virus, how it's fooling the B cell into surviving longer and bypasses B-cell signaling pathways, it's a credibly cleaver virus. And there's a lot of biology there that needs to be picked apart in the MS field. So there may be pathways in the EBV biological pathway that could be targeted rather than just targeting the virus itself. So I think there's lots of research to be done. This is why we, as an MS community, really need to bring virologists into the community as much as possible. And at the moment, that doesn't seem to be happening a lot. There's very few virologists interested in MS. You can count them on one hand to be honest with you that are really interested in MS. Most virologists are working on other diseases. And when you go to them, it's hard to get them interested in MS because MS is something on the periphery of their thought. They're usually targeting obviously infectious diseases. But most of the EBV virologists are working in oncology, lymphomas. MSDF Very good. Thank you. [transition music] MSDF Thank you for listening to Episode Fourteen of Multiple Sclerosis Discovery. This podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Robert Finn. Msdiscovery.org is part of the non-profit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is vice president of scientific operations. Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances. We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org. [outro music]
Welcome to Episode Fourteen of The Epic Questions Podcast!! Today is Sunday April 21, 2013. We've got a very special guest on the show today. He will help us answer questions about raiding, class, role, most embarrassing WoW moment, and much more. So grab a glass of noggenfogger, take a seat in your farm house, and enjoy the show.
Welcome to Episode Fourteen of the Community Animal Rescue Effort Pawdcast! Your source for all that wags, sniffs, barks and meows at the Evanston Animal Shelter. In this episode we’ll give you... C.A.R.E. is an all volunteer organization that works in conjunction with Evanston's municipal Animal Shelter to find homes for the abused and abandoned animals that are brought to the shelter. This monthly Pawdcast is your source for all that wags, sniffs, barks and meows at the Evanston Animal Shelter.
We have a special guest with us this week:Episode FourteenWe're joined by our friend Tom Greeves, who is a very talented and funny comedian, and also the former speech writer for Mayor Of London Boris Johnson. He some news for us from overseas, while iszi and Simon discuss manners and the sex appeal of pop stars.
Episode Fourteen of the continuing serial. It's time for the Doalis MasqueradeTheme music is "Faithful" by The Shillas.Incidental music is "Sunset Waltz" by Ken Kurland, courtesy of the Podsafe Music Network.Promo for Hypernonsense.Get the first episode of this serial here.Direct Download
© 2020-2025 Ivy Podcast Discovery LLC
