Podcasts about Showalter

After struggling to raise her siblings and start an art career, Wanda Gág’s life changed almost instantly with the publication of her first children’s book. Part two of her story looks at how her books sustained her financially so she could also make the art she wanted. Research: Anderson, Phil. "Gág, Wanda (1893–1946)." MNopedia, Minnesota Historical Society. http://www.mnopedia.org/person/g-g-wanda-1893-1946 Cox, Richard W. “Wanda Gág The Bite of the Picture Book.“ Minnesota History. Fall 1975. https://storage.googleapis.com/mnhs-org-support/mn_history_articles/44/v44i07p238-254.pdf?__hstc=98931905.4376bcd11fc21fde4cdd335d087cb15e.1742826273001.1742826273001.1742826273001.1&__hssc=98931905.1.1742826273001&__hsfp=979038277 Cox, Richard, and Julie L’Enfant. “Old World Symphony.” Minnesota History. Spring 1996. https://storage.googleapis.com/mnhs-org-support/mn_history_articles/55/v55i01p002-015.pdf?__hstc=98931905.4376bcd11fc21fde4cdd335d087cb15e.1742826273001.1742826273001.1742826273001.1&__hssc=98931905.1.1742826273001&__hsfp=979038277 Gág , Wanda. “Growing Pains.” Coward-McCann. 1940. https://ia801401.us.archive.org/10/items/in.ernet.dli.2015.88331/2015.88331.Growing-Pains-Diaries-And-Drawings-For-The-Years-1908-1917.pdf Gág , Wanda. “Millions of Cats.” Coward-McCann. 1928. https://www.google.com/books/edition/Millions_of_Cats/2YjWAAAAMAAJ?hl=en&gbpv=0 Gág , Wanda. “The Funny Thing.” Coward-McCann. 1991. https://www.google.com/books/edition/The_Funny_Thing/c1nhAAAAMAAJ?hl=en&gbpv=0 Gág , Wanda. “SNOW WHITE AND THE SEVEN DWARFS.” Coward-McCann. 1938. Accessed online: https://gutenberg.ca/ebooks/Gág -snow/Gág -snow-00-h-dir/Gág -snow-00-h.html Gág , Wanda. “Snippy and Snappy. Coward-McCann. 1931. Accessed online: https://gutenberg.ca/ebooks/Gág -snippy/Gág -snippy-00-h-dir/Gág -snippy-00-h.html Gregory, Alice. “Juicy As a Pear: Wanda Gág’s Delectable Books.” The New Yorker. April 24, 2014. https://www.newyorker.com/books/page-turner/juicy-as-a-pear-wanda-ggs-delectable-books?_sp=0d46b6ea-f03e-46b9-aa69-dd7bd3c6100b.1742826428861 Hurley, Beatrice J. “Wanda Gág - Artist, Author.” Elementary English, vol. 32, no. 6, 1955, pp. 347–54. JSTOR, http://www.jstor.org/stable/41384370 Keller, Sara. “Reciprocal Connections: Wanda Gág and her Hometown Community of new Ulm, Minnesota.” Kappa Omicron Nu. https://publications.kon.org/urc//v9/Interconnected-Through-Art/keller.pdf Popova, Maria. “Pioneering Early-Twentieth-Century Artist and Creative Entrepreneur Wanda Gág on Our Two Selves and How Love Lays Its Claim on Us.” The Marginalian. March 11, 2015. https://www.themarginalian.org/2015/03/11/wanda-Gág -growing-pains-me-myself/#:~:text=By%20Maria%20Popova,was%20already%20on%20her%20deathbed. Scott, Alma. “Wanda Gág : The Story of an Artist.” Kessinger Publishing. 2007. Showalter, Elaine. “These Modern Women: Autobiographical Essays from the Twenties.” Feminist Press at CUNY. 1989. “Wanda Gág.” Wanda Gág https://wandaGág house.org/wanda-Gág / Wigglesworth, Michael. “The Day of Doom.” Spiral Press. 1929. Accessed online: https://babel.hathitrust.org/cgi/pt?id=uva.x000889310&seq=9 Winnan, Audur H. “Wanda Gág .” University of Minnesota Press. 1993. See omnystudio.com/listener for privacy information.

As an artist and writer Wanda Gág is well known for her children’s books. But this first of two parts about her life covers her own unusual childhood, which went from quirky fun to intense hardship when her father died. Research: Anderson, Phil. "Gág, Wanda (1893–1946)." MNopedia, Minnesota Historical Society. http://www.mnopedia.org/person/g-g-wanda-1893-1946 Cox, Richard W. “Wanda Gág The Bite of the Picture Book.“ Minnesota History. Fall 1975. https://storage.googleapis.com/mnhs-org-support/mn_history_articles/44/v44i07p238-254.pdf?__hstc=98931905.4376bcd11fc21fde4cdd335d087cb15e.1742826273001.1742826273001.1742826273001.1&__hssc=98931905.1.1742826273001&__hsfp=979038277 Cox, Richard, and Julie L’Enfant. “Old World Symphony.” Minnesota History. Spring 1996. https://storage.googleapis.com/mnhs-org-support/mn_history_articles/55/v55i01p002-015.pdf?__hstc=98931905.4376bcd11fc21fde4cdd335d087cb15e.1742826273001.1742826273001.1742826273001.1&__hssc=98931905.1.1742826273001&__hsfp=979038277 Gág , Wanda. “Growing Pains.” Coward-McCann. 1940. https://ia801401.us.archive.org/10/items/in.ernet.dli.2015.88331/2015.88331.Growing-Pains-Diaries-And-Drawings-For-The-Years-1908-1917.pdf Gág , Wanda. “Millions of Cats.” Coward-McCann. 1928. https://www.google.com/books/edition/Millions_of_Cats/2YjWAAAAMAAJ?hl=en&gbpv=0 Gág , Wanda. “The Funny Thing.” Coward-McCann. 1991. https://www.google.com/books/edition/The_Funny_Thing/c1nhAAAAMAAJ?hl=en&gbpv=0 Gág , Wanda. “SNOW WHITE AND THE SEVEN DWARFS.” Coward-McCann. 1938. Accessed online: https://gutenberg.ca/ebooks/Gág -snow/Gág -snow-00-h-dir/Gág -snow-00-h.html Gág , Wanda. “Snippy and Snappy. Coward-McCann. 1931. Accessed online: https://gutenberg.ca/ebooks/Gág -snippy/Gág -snippy-00-h-dir/Gág -snippy-00-h.html Gregory, Alice. “Juicy As a Pear: Wanda Gág’s Delectable Books.” The New Yorker. April 24, 2014. https://www.newyorker.com/books/page-turner/juicy-as-a-pear-wanda-ggs-delectable-books?_sp=0d46b6ea-f03e-46b9-aa69-dd7bd3c6100b.1742826428861 Hurley, Beatrice J. “Wanda Gág - Artist, Author.” Elementary English, vol. 32, no. 6, 1955, pp. 347–54. JSTOR, http://www.jstor.org/stable/41384370 Keller, Sara. “Reciprocal Connections: Wanda Gág and her Hometown Community of new Ulm, Minnesota.” Kappa Omicron Nu. https://publications.kon.org/urc//v9/Interconnected-Through-Art/keller.pdf Popova, Maria. “Pioneering Early-Twentieth-Century Artist and Creative Entrepreneur Wanda Gág on Our Two Selves and How Love Lays Its Claim on Us.” The Marginalian. March 11, 2015. https://www.themarginalian.org/2015/03/11/wanda-Gág -growing-pains-me-myself/#:~:text=By%20Maria%20Popova,was%20already%20on%20her%20deathbed. Scott, Alma. “Wanda Gág : The Story of an Artist.” Kessinger Publishing. 2007. Showalter, Elaine. “These Modern Women: Autobiographical Essays from the Twenties.” Feminist Press at CUNY. 1989. “Wanda Gág.” Wanda Gág https://wandaGág house.org/wanda-Gág / Wigglesworth, Michael. “The Day of Doom.” Spiral Press. 1929. Accessed online: https://babel.hathitrust.org/cgi/pt?id=uva.x000889310&seq=9 Winnan, Audur H. “Wanda Gág .” University of Minnesota Press. 1993. See omnystudio.com/listener for privacy information.

JCO PO author Dr. Timothy Showalter at Artera and University of Virginia shares insights into his JCO PO article, “Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer” . Host Dr. Rafeh Naqash and Dr. Showalter discuss how multimodal AI as a prognostic marker in nonmetastatic castration-resistant prostate cancer may serve as a predictive biomarker with high-risk patients deriving the greatest benefit from treatment with apalutamide. TRANSCRIPT  Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations where we'll bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast Editor for JCO Precision Oncology and assistant professor at the OU Health Stephenson Cancer Center at the University of Oklahoma. Today, we are excited to be joined by Dr. Timothy Showalter, Chief Medical Officer at Artera and professor of Radiation Oncology at the University of Virginia and author of the JCO Precision Oncology article entitled, “Digital Pathology Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase 3 Trial in Men with Non-Metastatic Castration Resistant Prostate Cancer.” At the time of this recording, our guest's disclosures will be linked in the transcript. Dr. Showalter, it's a pleasure to have you here today. Dr. Timothy Showalter: It's a pleasure to be here. Thanks for having me. Dr. Rafeh Naqash: I think this is going to be a very interesting discussion, not just from a biomarker perspective, but also in terms of how technologies have evolved and how we are trying to stratify patients, trying to escalate or deescalate treatments based on biomarkers. And this article is a good example of that. One of the things I do want to highlight as part of this article is that Dr. Felix Feng is the first author for this article. Unfortunately, Dr. Felix Feng passed away in December of 2024. He was a luminary in this field of prostate cancer research. He was also the Chair of the NRG GU Committee as well as Board of Directors for RTOG Foundation and has mentored a lot of individuals from what I have heard. I didn't know Dr. Feng but heard a lot about him from my GU colleagues. It's a huge loss for the community, but it was an interesting surprise for me when I saw his name on this article as I was reviewing it. Could you briefly talk about Dr. Feng for a minute and how you knew him and how he's been an asset to the field? Dr. Timothy Showalter: Yeah. I'm always happy to talk about Felix whenever there's an opportunity. You know, I was fortunate to know Felix Feng for about 20 years as we met during our residency programs through a career development workshop that we both attended and stayed close ever since. And you know, he's someone who made an impact on hundreds of lives of cancer researchers and other radiation oncologists and physicians in addition to the cancer patients he helped, either through direct clinical care or through his innovation. For this project in particular, I first became involved soon after Felix had co-founded Artera, which is, you know the company that developed this. And because Felix was such a prolific researcher, he was actually involved in this and this research project from all different angles, both from the multimodal digital pathology tool to the trial itself and being part of moving the field forward in that way. It's really great to be able to sort of celebrate a great example of Felix's legacy, which is team science, and really moving the field forward in terms of translational projects based on clinical trials. So, it's a great opportunity to highlight some of his work and I'm really happy to talk about it with you. Dr. Rafeh Naqash: Thanks, Tim. Definitely a huge loss for the scientific community. And I did see a while back that there was an international symposium organized, showcasing his work for him to talk about his journey last year where more than 200, 250 people from around the globe actually attended that. That speaks volumes to the kind of impact he's had as an individual and impact he's had on the scientific side of things as well. Dr. Timothy Showalter: Yes. And we just had the second annual Feng Symposium the day before ASCO GU this year with, again, a great turnout and some great science highlighted, as well as a real focus on mentorship and team science and collaboration. Dr. Rafeh Naqash: Thank you so much for telling us all about that. Now going to what you guys published in JCO Precision Oncology, which is this article on using a biomarker approach to stratify non-metastatic prostate cancer using this artificial intelligence based H&E score. Could you tell us the background for what started off this project? And I see there is a clinical trial data set that you guys have used, but there's probably some background to how this score or how this technology came into being. So, could you superficially give us an idea of how that started? Dr. Timothy Showalter: Sure. So, the multimodal AI score was first published in a peer reviewed journal back in 2022 and the test was originally developed through a collaboration with the Radiation Therapy Oncology Group or Energy Oncology Prostate Cancer Research Team. The original publication describes development and validation of a risk stratification tool designed to predict distant metastasis and prostate cancer specific mortality for men with localized prostate cancer. And the first validation was in men who were treated with definitive radiation therapy. There have been subsequent publications in that context and there's a set of algorithms that have been validated in localized prostate cancer and there's a test that's listed on NCCN guidelines based on that technology. The genesis for this paper was really looking at extending that risk stratification tool that was developed in localized prostate cancer to see if it could one, validate in a non-metastatic castrate refractory prostate cancer population for patients enrolled on the SPARTAN trial. And two, whether there was a potential role for the test output in terms of predicting benefit from apalutamide for patients with non-metastatic prostate cancer. For patients who are enrolled on the SPARTAN study, almost 40% of them had H&E stain biopsy slide material available and were eligible to be included in this study. Dr. Rafeh Naqash: Going a step back to how prostate cancer, perhaps on the diagnostic side using the pathology images is different as you guys have Gleason scoring, which to the best of my knowledge is not necessarily something that most other tumor types use. Maybe Ki-67 is somewhat of a comparison in some of the neuroendocrine cancers where high Ki-67 correlates with aggressive biology for prognosis. And similarly high Gleason scores, as we know for some of the trainees, correlates with poor prognosis. So, was the idea behind this based on trying to stratify or sub-stratify Gleason scoring further, where you may not necessarily know what to do with the intermediate high Gleason score individual tumor tissues? Dr. Timothy Showalter: Well, yeah. I mean, Gleason score is a really powerful risk stratification tool. As you know, our clinical risk groupings are really anchored to Gleason scores as an important driver for that. And while that's a powerful tool, I think, you know, some of the original recognition for applying computer vision AI into this context is that there are likely many other features located in the morphology that can be used to build a prognostic model. Going back to the genesis of the discovery project for the multimodal AI model, I think Felix Feng would have described it as doing with digital pathology and computer vision AI what can otherwise be done with gene expression testing. You know, he would have approached it from a genomic perspective. That's what the idea was. So, it's along the line of what you're saying, which is to think about assigning a stronger Gleason score. But I think really more broadly, the motivation was to come up with an advanced complementary risk stratification tool that can be used in conjunction with clinical risk factors to help make better therapy recommendations potentially. So that was the motivation behind it. Dr. Rafeh Naqash: Sure. And one of the, I think, other important teaching points we try to think about, trainees of course, who are listening to this podcast, is trying to differentiate between prognostic and predictive scores. So, highlighting the results that you guys show in relation to the MMAI score, the digital pathology score, and outcomes as far as survival as well as outcomes in general, could you try to help the listeners understand the difference between the prognostic aspect of this test and the predictive aspect of this test? Dr. Timothy Showalter: So let me recap for the listeners what we found in the study and how it kind of fits into the prognostic and the predictive insights. So, one, you know, as I mentioned before, this is ultimately a model that was developed and validated for localized prostate cancer for risk stratification. So, first, the team looked at whether that same tool developed in localized prostate cancer serves as a prognostic tool in non-metastatic castrate-refractory prostate cancer. So, we applied the tool as it was previously developed and identified that about 2/3 of patients on the SPARTAN trial that had specimens available for analysis qualified as high risk and 1/3 of patients as either intermediate or low risk, which we called in the paper ‘non-high risk'. And we're able to show that the multimodal AI score, which ranges from 0 to 1, and risk group, was associated with metastasis free survival time to second progression or PFS 2 and overall survival. And so that shows that it performs as a prognostic tool in this setting. And this paper was the first validation of this tool in non-metastatic castrate-refractory prostate cancer. So, what that means to trainees is basically it helps you understand how aggressive that cancer is or better stratify the risk of progression over time. So that's the prognostic performance. Dr. Rafeh Naqash: Thank you for trying to explain that. It's always useful to get an example and understand the difference between prognostic and predictive. Now again, going back to the technology, which obviously is way more complicated than the four letter word MMAI, I per se haven't necessarily done research in this space, but I've collaborated with some individuals who've done digital pathology assessments, and one of the projects we worked on was TIL estimation and immune checkpoint related adverse events using some correlation and something that one of my collaborators had sent to me when we were working on this project as part of this H&E slide digitalization, you need color deconvolution, you need segmentation cell profiling. Superficially, is that something that was done as part of development of this MMAI score as well? Dr. Timothy Showalter You need a ground truth, right? So, you need to train your model to predict whatever the outcome is. You know, if you're designing an AI algorithm for Ki-67 or something I think you mentioned before, you would need to have a set of Ki-67 scores and train your models to create those scores. In this case, the clinical annotation for how we develop the multimodal AI algorithm is the clinical endpoints. So going back to how this tool was developed, the computer vision AI model is interpreting a set of features on the scan and what it's trying to do is identify high risk features and make a map that would ultimately predict clinical outcomes. So, it's a little bit different than the many digital pathology algorithms where the AI is being trained to predict a particular morphological finding. In this case, the ground truth that the model is trained to predict is the clinical outcome. Dr. Rafeh Naqash: Sure. And from what you explained earlier, obviously, tumors that had a high MMAI score were the ones that were benefiting the most from the ADT plus the applausive. Is this specific for this androgen receptor inhibitor or is it interchangeable with other inhibitors that are currently approved? Dr. Timothy Showalter: That's a great question and we don't know yet. So, as you're alluding to, we did find that the MMAI risk score was predictive for benefit from apalutamide and so it met the statistical definition of having a significant interaction p value so we can call it a predictive performance. And so far, we've only looked in this population for apalutamide. I think you're raising a really interesting point, which is the next question is, is this generalizable to other androgen receptor inhibitors? There will be future research looking at that, but I think it's too early to say. Just for summary, I think I mentioned before, there are about 40% of patients enrolled on the SPARTAN study had specimens available for inclusion in this analysis. So, the SPARTAN study did show in the entire clinical trial set that patients with non-metastatic castrate-refractory prostate cancer benefited from apalutamide. The current study did show that there seems to be a larger magnitude of benefit for those patients who are multimodal AI high risk scores. And I think that's very interesting research and suggests that there's some interaction there. But I certainly would want to emphasize that we have not shown that patients with intermediate or low risk don't benefit from apalutamide. I think we can say that the original study showed that that trial showed a benefit and that we've got this interesting story with multimodal AI as well. Dr. Rafeh Naqash: Sure. And I think from a similar comparison, ctDNA where ctDNA shows prognostic aspects, I treat people with lung cancer especially, and if you're ctDNA positive at a 3 to 4-month period, likely chances of you having a shorter disease-free interval is higher. Same thing I think for colorectal cancers. And now there are studies that are using ctDNA as an integral biomarker to stratify patients positive/negative and then decide on escalation/de-escalation of treatment. So, using a similar approach, is there something that is being done in the context of the H&E based stratification to de-intensify or intensify treatments based on this approach? Dr. Timothy Showalter: You're hitting right on the point in the most promising direction. You know, as we pointed out in the manuscript, one of the most exciting areas as a next step for this is to use a tool like this for stratification for prospective trials. The multimodal AI test is not being used currently in clinical trials of non-metastatic castrate-refractory prostate cancer, which is a disease setting for this paper. There are other trials that are in development or currently accruing where multimodal AI stratification approach is being taken, where you see among the high-risk scores, at least in the postoperative setting for a clinical trial that's open right now, high risk score patients are being randomized to basically a treatment intensification question. And then the multimodal AI low risk patients are being randomized to a de-intensification experimental arm where less androgen deprivation therapy is being given. So, I think it's a really promising area to see, and I think what has been shown is that this tool has been validated really across the disease continuum. And so, I think there are opportunities to do that in multiple clinical scenarios. Dr. Rafeh Naqash: Then moving on to the technological advancements, very fascinating how we've kind of evolved over the last 10 years perhaps, from DNA based biomarkers to RNA expression and now H&E. And when you look at cost savings, if you were to think of H&E as a simpler, easier methodology, perhaps, with the limitations that centers need to digitalize their slides, probably will have more cost savings. But in your experience, as you've tried to navigate this H&E aspect of trying to either develop the model or validate the model, what are some of the logistics that you've experienced can be a challenge? As we evolve in this biomarker space, how can centers try to tackle those challenges early on in terms of digitalizing data, whether it's simple data or slides for that matter? Dr. Timothy Showalter: I think there's two main areas to cover. One, I think that the push towards digitalization is going to be, I think, really driven by increasing availability and access to augmentative technologies like this multimodal AI technology where it's really adding some sort of a clinical insight beyond what is going to be generated through routine human diagnostic pathology. I think that when you can get these sorts of algorithms for patient care and have them so readily accessible with a fast turnaround time, I think that's really going to drive the field forward. Right now, in the United States, the latest data I've seen is that less than 10% of pathology labs have gone digital. So, we're still at an early stage in that. I hope that this test and similar ones are part of that push to go more digital. The other, I think, more interesting challenge that's a technical challenge but isn't about necessarily how you collect the data, but it certainly creates data volume challenges, is how do you deal with image robustness and sort of translating these tools into routine real-world settings. And as you can imagine, there's a lot of variation for staining protocols, intensity scanner variations, all these things that can affect the reliability of your test. And at least for this research group that I'm a part of that has developed this multimodal AI tool can tell you that the development is sophisticated, but very data and energy intensive in terms of how to deal with making a tool that can be consistent across a whole range of image parameters. And so that presents its own challenges for dealing with a large amount of compute time and AI cycles to make robust algorithms like that. And practically speaking, I think moving into other diseases and making this widely available, the size of data required and the amount of cloud compute time will be a real challenge. Dr. Rafeh Naqash: Thank you for summarizing. I can say that definitely, you know, this is maybe a small step in prostate cancer biomarker research, but perhaps a big step in the overall landscape of biomarker research in general. So definitely very interesting. Now, moving on to the next part of the discussion is more about you as a researcher, as an individual, your career path, if you can summarize that for us. And more interestingly, this intersection between being part of industry as well as academia for perhaps some of the listeners, trainees who might be thinking about what path they want to choose. Dr. Timothy Showalter: Sure. So, as you may know, I'm a professor at the University of Virginia and I climbed the academic ladder and had a full research grant program and thought I'd be in academia forever. And my story is that along the way, I kind of by accident ended up founding a medical device company that was called Advaray and that was related to NCI SBIR funding. And I found myself as a company founder and ultimately in that process, I started to learn about the opportunity to make an impact by being an innovator within the industry space. And that was really the starting point for me. About four years ago, soon after Felix Feng co-founded Artera, he called me and told me that he needed me to join the company. For those who were lucky to know Felix well, at that very moment, it was inevitable that I was going to join Artera and be a part of this. He was just so persuasive. So, I will say, you know, from my experience of being sort of in between the academic and industry area, it's been a really great opportunity for me to enter a space where there's another way of making an impact within cancer care. I've gotten to work with top notch collaborators, work on great science, and be part of a team that's growing a company that can make technology like this available. Dr. Rafeh Naqash: Thank you so much, Tim, for sharing some of those thoughts and insights. We really appreciate you discussing this very interesting work with us and also appreciate you submitting this to JCO Precision Oncology and hopefully we'll see more of this as this space evolves and maybe perhaps bigger more better validation studies in the context of this test. Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

For Christian parents whose children have embraced an LGBTQ+ identity, the world is full of confusion, manipulation, and emotional pain. Watching your child go through gender confusion and irreversible medical procedures is heart-wrenching. Navigating this world feels isolating and often spiritually and emotionally draining. There's a need for truth, empathy, and a support system that isn't afraid to stand firm in God's design for humanity. In this episode, Brandon Showalter, a passionate advocate for truth and a journalist for the Christian Post, is joining Melinda on The Bridge Between Us Podcast. With years of experience and a personal commitment to truth, Brandon offers both emotional support and practical advice.  Listen is to discover:  The Deception of Language One of the most insidious aspects of gender ideology is the manipulation of language. Brandon highlights how changing the meaning of basic words, like “gender” and “sex,” sows confusion and disrupts the ability to speak truthfully about the human body and identity. Spiritual Warfare and the Church's Role In this battle against gender ideologies, Brandon discusses how the church must not only engage in policy change but also engage spiritually. The importance of persistent prayer and maintaining vigilance is underscored. The need for the church to stand firm against this deception is crucial in reclaiming the truth of God's design for humanity. The Role of the Church in the Battle As society grapples with this issue, the church is called to be a place of healing and truth. The need to accept and minister to those who are struggling with gender identity is vital, but it requires both compassion and the courage to speak the truth. Parents on the Frontlines Parents are urged to be proactive in protecting their children from harmful ideologies and pseudoscience. Despite the cultural push for tolerance, Brandon explains that compassion and kindness should not require compromising truth.   We are in the midst of a spiritual battle, but as believers, we are equipped with the truth of God's word and the power of prayer. Let's stay vigilant, stand firm, and continue to share the love of Christ with a world in desperate need of His transformative hope.   Connect with Brand Showalter:  Exposing The Gender Lie: How To Protect Children and Teens From the Trangender Industry's False Ideology The Christian Post

Michael chats with John Showalter, Chief Strategy Officer of Linus Health, a digital health company focusing on brain health. The two talk about the current state of early detection and management of cognitive disorders, barriers in traditional assessments and interoperability and how AI and innovation is enhancing assessments and improving patient outcomes.  

Director John Showalter talks to us about some behind the scenes moments and discusses the performances of Jensen, Cindy and Sebastian. Rob and Rich are surprised to learn that H.P. Lovecraft is a real person. Learn more about your ad choices. Visit megaphone.fm/adchoices

The first two weeks of President Donald Trump's second term have been a whirlwind of executive orders on a wide variety of issues, including some against gender ideology. What do these orders against gender ideology actually accomplish, and what do they leave aside?On this week's episode, Brandon Showalter of the Christian Post unpacks these executive orders and what they really mean in the fight against the transgender agenda. Above all, Showalter cautions us to remember that transgender activists won't just give up because they're losing a few battles in the culture war.U.S. residents! Create a will with LifeSiteNews: https://www.mylegacywill.com/lifesitenews ****PROTECT Your Wealth with gold, silver, and precious metals: https://stjosephpartners.com/lifesitenews+++SHOP ALL YOUR FUN AND FAVORITE LIFESITE MERCH! https://shop.lifesitenews.com/ ****Download the all-new LSNTV App now, available on iPhone and Android!LSNTV Apple Store: https://apps.apple.com/us/app/lsntv/id6469105564 LSNTV Google Play: https://play.google.com/store/apps/details?id=com.lifesitenews.app +++Connect with John-Henry Westen and all of LifeSiteNews on social media:LifeSite: https://linktr.ee/lifesitenews John-Henry Westen: https://linktr.ee/jhwesten Hosted on Acast. See acast.com/privacy for more information.

In this week's show, we talk to Lucas Wilson, Seth Showalter, and Brandan Robertson about "shame sex attraction" and how gay conversion therapy is neither therapy nor works to "convert" anyone to anything but someone who has to endure guilt and shame.If you want to call in to the Bonus Show, leave a voicemail at (530) 332-8020. We would love to get to your calls!LINKSQuoirCast on PatreonQuoirCast on PatheosPANELISTSLucas WilsonSeth ShowalterBrandan Robertson

This week on TABLE TALK, Jeff sat down with Buck Showalter, Veronica Alvarez, and Gary “Sarge” Matthews out at the Reading Hot Stovers annual banquet in center city Reading for a discussion about their impacts on the game of baseball and how the baseball world is changing. We also spoke to some local high school scholarship recipients thanks to the Reading Hot Stovers organization. These were great discussions!Head over to our website for all of our podcasts and more: philadelphiasportstable.com.Follow us on BlueSky:Jeff: @jeffwarren.bsky.socialErik: @brickpollitt.bsky.socialFollow us on Threads:Jeff: @mrjeffwarrenErik: @slen1023The Show: @philadelphiasportstableFollow us on Twitter/X:Jeff: @Jeffrey_WarrenErik: @BrickPollittThe Show: @PhiladelphiaPSTFollow the show on Instagram: instagram.com/philadelphiasportstable.

March 2, 1996. Culpepper County, Virginia. After leaving her home in Baltimore, Maryland in order to drive to Charlottesville, 25-year old Alicia Showalter Reynolds goes missing and her abandoned car is found alongside U.S. Route 29. Eyewitnesses report having seen Alicia speaking with an unidentified man in a pick-up truck and it becomes apparent that he may have tricked Alicia into pulling over before abducting her. Two months later, Alicia's body is discovered in a remote field and while it is theorized that she fell prey to a killer known as the “Route 29 Stalker”, no one is ever charged with her murder. On this week's episode of “The Trail Went Cold”, we explore the death of Alicia Showalter Reynolds, a crime which has had some compelling suspects over the years, but remains unsolved. Additional Reading: https://unsolved.com/gallery/alicia-showalter/ https://unsolvedmysteries.fandom.com/wiki/Alicia_Showalter_Reynolds https://www.washingtonpost.com/archive/local/1996/05/09/culpeper-body-is-that-of-md-woman/b7b731e7-0d2f-4389-9a8c-40bb178e60c2/ https://www.washingtonpost.com/archive/local/1996/11/16/their-name-linked-to-stalker-larry-breedens-bear-a-burden/8f991bdb-3940-48cd-a3a1-1ef188dcbd2e/?utm_term=.c800767169fd https://scholar.lib.vt.edu/VA-news/ROA-Times/issues/1997/rt9703/970302/03030076.htm https://en.wikipedia.org/wiki/Missing_persons_cases_along_U.S._Route_29_in_Virginia https://www.nvdaily.com/nvdaily/police-continue-to-search-for-alicia-reynolds-killer/article_645eff83-4236-5969-afd3-3ef583a5dd9d.html https://www.29news.com/2021/05/07/family-alicia-showalter-reynolds-still-looking-answers-years-after-her-death/ https://dailyprogress.com/news/community/madisonnews/police-continue-to-investigate-showalter-reynolds-homicide/article_d857aa78-da96-11ee-a14a-0b1ad05a8707.html https://pix11.com/news/suspect-sketch-in-1996-virginia-murder-looks-like-accused-gilgo-killer-victims-family-says/ https://www.fredericksburgfreepress.com/2024/03/01/state-police-continue-to-investigate-the-disappearance-and-homicide-of-alicia-showalter-reynolds/ “The Trail Went Cold” will be appearing at the AdvocacyCon, taking place at the Indianapolis Marriott East in Indianapolis on March 28-30, 2025. To get a 10 % discount on tickets, please use our specialized promo code, “TRAIL10”, by visiting https://www.advocacycon.com/. “The Trail Went Cold” is on Patreon. Visit www.patreon.com/thetrailwentcold to become a patron and gain access to our exclusive bonus content. The Trail Went Cold is produced and edited by Magill Foote. All music is composed by Vince Nitro.

Christmas Eve, 1973. New London, Connecticut. While changing a tire, 20-year old Kevin Showalter is struck by a passing vehicle and killed in a hit-and-run. When the local police botch the investigation and make no effort to solve the case, Kevin's mother is forced to fight for answers on her own. Years later, a grand jury investigation is launched and the town's former mayor is named as the probable driver of the vehicle. However, further complications ensue when another man comes forward and confesses to the crime, creating debate about who was actually responsible for Kevin's death. This week's episode of “The Path Went Chilly” will be examining what is perhaps the most extensive and controversial hit-and-run case in the history of the United States, which has still not found a conclusive resolution after four decades.Patreon.com/julesandashleyPatreon.com/thetrailwentcoldAdditional Reading:http://people.com/archive/a-mothers-anguish-kept-alive-a-sons-memory-and-her-lonely-search-for-his-hit-and-run-killer-vol-10-no-3/http://articles.courant.com/2005-12-12/news/0512120514_1_grand-jury-mr-hansen-casehttp://cooljustice.blogspot.ca/2013/02/this-is-what-grand-jury-report-looks.htmlhttp://cooljustice.blogspot.ca/2016/09/hit-and-run-chronology-grand-jury.html

Christmas Eve, 1973. New London, Connecticut. While changing a tire, 20-year old Kevin Showalter is struck by a passing vehicle and killed in a hit-and-run. When the local police botch the investigation and make no effort to solve the case, Kevin's mother is forced to fight for answers on her own. Years later, a grand jury investigation is launched and the town's former mayor is named as the probable driver of the vehicle. However, further complications ensue when another man comes forward and confesses to the crime, creating debate about who was actually responsible for Kevin's death. This week's episode of “The Path Went Chilly” will be examining what is perhaps the most extensive and controversial hit-and-run case in the history of the United States, which has still not found a conclusive resolution after four decades.Patreon.com/julesandashleyPatreon.com/thetrailwentcoldAdditional Reading:http://people.com/archive/a-mothers-anguish-kept-alive-a-sons-memory-and-her-lonely-search-for-his-hit-and-run-killer-vol-10-no-3/http://articles.courant.com/2005-12-12/news/0512120514_1_grand-jury-mr-hansen-casehttp://cooljustice.blogspot.ca/2013/02/this-is-what-grand-jury-report-looks.htmlhttp://cooljustice.blogspot.ca/2016/09/hit-and-run-chronology-grand-jury.html

In this delightfully salty episode, language and PAC expert Amy Showalter joins the Facts About PACs crew to drop truth bombs about the words and phrases we should all retire in 2025. From the eye-roll-inducing "going forward" to the overused "historic," no corporate buzzword or political cliché is safe from Showalter's witty critique. Listen as hosts Micaela Isler, David Schild, and Adam Belmar navigate this verbal minefield with humor and insight.

In the latest episode of "F-Stop Collaborate and Listen," host Matt Payne delves into the passion and perseverance required in the field of conservation photography with guest Dave Showalter. The conversation starts with the exploration of perseverance—a crucial trait for photographers. Many individuals face frustrations when trying to discover their unique voice and vision, often encountering rejections and funding challenges, particularly in conservation work. Showalter recounts his experience of long-term dedication, underscoring the necessity of pushing through setbacks and rejections. He even shares practical tips from his personal journey, like opting to sleep in his truck to save costs. Explore practical strategies for organizing and executing impactful conservation projects, which can transform your approach to storytelling and advocacy in photography. Join us for a discussion that will surely inspire you to get out there and make meaningful photographs! Don't miss an episode! Sign up for our weekly mailing list! Resources Mentioned on the Podcast Elements Photo Magazine Dave Showalter's Book - Living River Support the podcast on Patreon Western Rivers Action Network Platte Basin Time Lapse The Land Desk Blog by Jonathan Thompson Matt's Colorado Trail Podcast episode Tribal Water Center Kerrin Burke Lahr's Svalbard images and stories The Creative Act by Rick Rubin (Affiliate Link) Photographers Recommended Michael Forsberg Amy Gulick Clay Bolt Alan Murabayashi

Let's get ready for the weekend on this 'Feelgood Friday' with Colleen Showalter of Portugal The Place - https://portugaltheplace.com, and the GuMPers of our wonderful community.Colleen will reflect, from her point of view, about the post-US-Election effect here in Portugal and our Filmmaker Laureate - Andy Cline - will give us non-American foreigners an introduction to Thanksgiving, ahead of the big day.What are you up to this weekend, in Portugal?Join the Portugal Club for direct access to Carl Munson and the Good Morning Portugal! professional and social network - www.theportugalclub.comWant to create live shows like mine? Try https://streamyard.com/pal/d/4668289695875072Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.

Alicia Showalter Reynolds was just 25 years old when she disappeared during a drive from her home in Baltimore to a mall in Virginia. Was she the victim of the still-unidentified Route 29 Stalker? Alicia's case remains unsolved, but investigators insist that it isn't cold. Will Alicia's friends and family ever get answers or will her case continue to go unsolved? If you have any information about the murder of Alicia Showalter Reynolds, please contact the Virginia State Police at 1-800-572-2260 Listen Ad Free And Get Access to Exclusive Journal Entries Episodes: Spotify: https://open.spotify.com/show/4HEzJSwElA7MkbYYie9Jin Patreon: https://www.patreon.com/themurderdiariespod Apple: Hit subscribe/ 1 week free trail available Sponsorship Links: Sign up for a one-dollar-per-month trial period and take your retail business to the next level today! https://shopify.com/murderdiaries Go to https://aquatru.com/ and enter code: DIARIES to get 20% off any AquaTru purifier! Resources: https://themurderdiariespodcast.com/episodes Music Used: Walking with the Dead by Maia Wynne Link: https://freemusicarchive.org/music/Maiah_Wynne/Live_at_KBOO_for_A_Popcalypse_11012017 License: https://creativecommons.org/licenses/by-nc-nd/4.0/ Glitter Blast by Kevin MacLeod Link: https://filmmusic.io/song/4707-glitter-blast License: https://filmmusic.io/standard-license Imagefilm 018 by Sascha Ende Free download: https://filmmusic.io/song/315-imagefilm-018 License (CC BY 4.0): https://filmmusic.io/standard-license Our Links: Link Hub: https://msha.ke/themurderdiaries Instagram: https://www.instagram.com/themurderdiariespod/ Edited by: https://www.landispodcastediting.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Target Cancer Podcast, Dr. Sanjay Juneja sits down with Dr. Tim Showalter, Chief Medical Officer at Artera, to explore the transformative role of AI in personalizing cancer treatment. Dr. Showalter shares insights on how advanced AI tools are helping clinicians make more precise decisions, reducing overtreatment, and improving patients' quality of life. Together, they discuss the moral and medical challenges of balancing aggressive cancer therapies with patient-centered care and the promise of AI in guiding better, data-driven outcomes.

Text: 2 Timothy 2:15 "Be diligent to present yourself approved to God, a worker who does not need to be ashamed, rightly dividing the word of truth." NKJV

Great study of colossians.

Brandon Showalter is the host of “The Generation Indoctrination: Inside the Transgender Battle” documentary podcast from The Christian Post. He has spent years revealing the “growing and metastasizing transgender craze in America” and his reporting works to expose “one of the worst medical scandals of our time.” Listen as Mr. Showalter breaks down what to expect from Season 4 of his podcast documentary with The Washington Times Higher Ground's Billy Hallowell.FOLLOW BILLY ON SOCIAL MEDIA:- Follow Billy on Twitter- Follow Billy on Instagram- Follow Billy on Facebook- Follow Billy on YouTube- Follow Billy on Threads

Tyron McAlpin's lawyer joined the show and tells us Tyron was in jail for 24 days!

Jesse Showalter calls in and says Tyron was in jail for 24 days after his arrest outside a Circle K. 

Text: Matthew 14:1-36

How Are You Wired? Is a leadership podcast developed by local high school basketball coaches, Joe Willis (Plant High School) and Billy Teeden (Plant City High School). In this episode, Coach Teeden and Coach Willis speak to the USA Basketball Director of Coach Development, Don Showalter, about how he is wired and what makes the best the best. How Are You Wired? is presented by the Florida Association of Basketball Coaches (FABC). fabchoops.com/@FABCHoops (X/Twitter)How Are You Wired? is sponsored by PeeWee Callins. https://www.facebook.com/peewee.callinshttps://www.instagram.com/peeweecallins/We would enjoy your feedback for our podcast. Please reach out to us to let us know your thoughts.@HowAreYouWired (X/Twitter)Joe Willis: Plant HS Basketball, plantbasketball@gmail.com or @CoachWillis20 (X/Twitter)Billy Teeden: Plant City HS Basketball, william.teeden@hcps.net or @CoachTeeden (X/Twitter)

In this episode we interviewed Nicole Nightengale(AKA County Girl Flower), Kyle Nance( An antique extraordinaire), and rounding it off with a Junior at South Gray, Keagan Showalter.

Director John Showalter shares stories of working with babies, his journey with Supernatural, and behind-the-scenes stories. Do you think we'll ever see that rewatch project Jensen and Danneel made? Sam + Dean + Babies = Fun! Learn more about your ad choices. Visit megaphone.fm/adchoices

Divorce is not "one size fits all" and what works for one family may not work for another. This week, Michelle Dempsey-Multack is joined by holistic divorce attorney Morgan Foster who is a divorced mother herself and can provide her clients with empathy and understanding during the divorce process. Michelle and Morgan will dig deep into Knowing how long to try and "fix" a problem in your marriage Paying attention to the mental toll this is taking on you and your children Focusing on being the best version of yourself AND MORE! Former partner at McAllister, DeTar, Showalter & Walker, LLC and the head of the firm's family law practice, Morgan's work concentrates on a variety of familial legal matters, including divorce, alimony, custody, visitation, child support, and division of property. She is also the creator of the blog Divorcing Gracefully, which is designed to offer practical, informal, and accessible information about a number of challenging and complex family law topics. Having experienced divorce herself, Morgan has established a holistic divorce educational service called The Pivot Process.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Journalist, denominational mutt, and little-o orthodox Christian Brandon Showalter covers the “gender beat” at the Christian Post. He fills us in on how gender ideology is infiltrating churches, and answers: What is a Christian? What is gnosticism? How do denominations differ? What are human rights? What state has the worst drivers? (Maryland.) We also discuss the Nicene Creed, Reality's Last Stand, heresy, redemption, the flesh, self-idolatry, bioethics, the rise of the “nones”, evangelism, zealotry, sex scandals, martyrdom, persecution complexes, and how resistance to gender ideology is overcoming political divides. In the words of the world's most beloved un-killable zombie, you will know the truth, and the truth will set you free (John 8:31). Links Brandon Showalter at the Christian Post: https://www.christianpost.com/by/brandon-showalter Brandon Showalter on Twitter: https://x.com/BrandonMShow Generation Indoctrination podcast: https://open.spotify.com/show/0voIUbVZu44iuZHtV3QIcm https://www.youtube.com/playlist?list=PLBv_c__WF0jR0nl75FFNL68ryueQPTihu Deadname documentary: https://www.deadnamedocumentary.com/ Lesbian Julia Beck speaks at the Heritage Foundation: https://www.youtube.com/watch?v=_l1DoUXAdH0&ab_channel=TheHeritageFoundation 2019 Heritage Foundation panel The Inequality of the Equality Act: Concerns from the Left: https://www.youtube.com/watch?v=HMj9MOuRswc&t=0s&ab_channel=TheHeritageFoundation WRONG BODIES by Skirt Go Spinny: https://x.com/wrongbodies/status/1811125941541687316 Jesus Christ Superstar - Simon Zealotes: https://www.youtube.com/watch?v=AOMgCUcmJkI&ab_channel=MishaTsiklauri Facing East by Frederica Mathews-Green: https://www.harpercollins.com/products/facing-east-frederica-mathewes-green Owen Cyclops: https://owencyclops.com/about/ We Are Repaganizing by Louise Perry: https://www.firstthings.com/article/2023/10/we-are-repaganizing DOMINION by Tom Holland: https://www.hachettebookgroup.com/titles/tom-holland/dominion/9780465093502/?lens=basic-books Pamela Paul NYT opinion piece: https://www.nytimes.com/2024/07/12/opinion/gender-affirming-care-cass-review.html Mary Daly: https://en.wikipedia.org/wiki/Mary_Daly John 8:31: https://www.biblegateway.com/passage/?search=John%208%3A31-32&version=ESV --- Support this podcast: https://podcasters.spotify.com/pod/show/heterodorx/support

When did it become medically ethical to remove healthy body parts? Host Joseph Backholm is joined by Christian Post journalist, Brand Showalter, for a conversation dissecting the transgender cult. Brandon has spent many years tracking the transgender movement and shares some of what he has learned from watching and researching the movement throughout the years. He sheds light on where in the social and political “life cycle” the trans movement is, do people actually believe in this, and how transgenderism came onto the social scene. Resources ⁠Generation Indoctrination Podcast⁠ ⁠Dead Name documentary⁠ Read ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Washington Stand⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, featuring news and commentary from a biblical worldview. Published by ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Family Research Council⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

Dozens of leading Democrats united to force Joe Biden out of the presidential race. But which names actually tipped Biden over the edge? And how does the race look now that Kamala is on top of the ticket? Veteran reporter Mark Halperin called the Biden story perfectly, and joins Charlie to talk about Nancy Pelosi's unexpected influence, whether Trump should debate Kamala, and a lot more. Plus, Brandon Showalter talks about Harris's close links to the trans tyranny of California.Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Buck Showalter oversaw the last run of great Orioles teams, guiding his team to the playoffs three times in a five-year span from 2012-16. Now that the veteran skipper is on the other side, can he appreciate what the O's have accomplished over the last two seasons?   On the latest episode of The Adam Jones Podcast, Showalter joins Adam Jones and Jerry Coleman to talk about the state of today's game (3:03), managing superstars (7:20), incorporating analytics (8:52), MLB draft strategy (12:25), this year's O's team (15:25), ejections (26:49), working under John Angelos and George Steinbrenner (32:35), the pitch timer (38:13) and more.   Then Adam and Jerry talk discuss the Orioles' impressive June (49:05), All-Star weekend (51:00), Olympic baseball (54:58) and more.