Podcasts about Feng

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Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com https://www.facebook.com/melissaparkspsychicMelissa's Shop: https://shop.spreadshirt.com/melissaparkspsychiccreationsLeave a Review for Melissa on Google: https://maps.app.goo.gl/sXm86FLU9cnDcRVD6Melissa's Venmo: https://account.venmo.com/u/Melissa-Parks-37Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

You just need one or two things that feel undeniably aligned with the chapter you're living. Feng Shui is not about doing more. It's about doing the right thing — for you — with intention.   RESOURCES:   join the conversation | *Become Your Own Feng Shui Consultant* course download my FREE office guide | Let's Feng the Shui Out of Your Office learn | 9 red candle ritual   subscribe to the newsletter | Simple Shui buy the book | Simple Shui for Every Day: 365 Ways to Feng Shui Your Life follow along | Instagram

China is likely to announce additional stimulus policies, including extra fiscal support, targeted monetary easing and stronger consumption-boosting initiatives, to put its economic growth on a more solid footing, as the country's top leadership usually convenes a high-level meeting centered on economic issues around the end of April, analysts said.分析人士表示，中国有望宣布更多刺激政策，包括增加财政支持、定向货币宽松以及更有力的促消费举措，以进一步夯实经济增长基础。中国最高领导层通常会在4月底左右召开一次以经济问题为中心的高层会议。The tone-setting meeting would be an important occasion for China's policymakers to reassess the fast-paced developments in the trade war initiated by Washington against Beijing over the past month, and to formulate offsetting policies in response, they added.他们补充道，此次定调会议将成为中国政策制定者重新评估过去一个月华盛顿对北京发起的贸易战快速发展态势，并制定相应政策的重要契机。"While the 5.4 percent GDP growth rate in the first quarter is a good start, key indicators like the consumer price index and producer price index suggest that weakness in domestic demand still persists," said Xiong Yuan, chief economist at Guosheng Securities.国盛证券首席经济学家熊园表示：“虽然第一季度GDP增长率达到5.4%是一个良好的开端，但消费者价格指数和生产者价格指数等关键指标表明，国内需求仍然疲软。”The impact of the tariffs by the United States, which is expected to materialize more visibly in the second quarter, further underscores the urgency for policymakers to ramp up supportive efforts, Xiong said.熊园表示，预计美国加征关税的影响将在第二季度更加明显，这进一步凸显了政策制定者加大支持力度的紧迫性。China's top leadership has suggested on various occasions that the country has ample capability to roll out new policy measures as needed, to address the rising uncertainties in the external environment.中国高层领导已多次表示，中国有足够的能力根据需要推出新的政策措施，以应对外部环境中日益增加的不确定性。Premier Li Qiang said on April 17 during a study session held by the State Council—the country's Cabinet—that at critical moments, the government must act swiftly to deploy policy tools across various fronts in order to generate positive market expectations.4月17日，李强总理在国务院举行的一次学习会议上表示，在关键时刻，政府必须迅速行动，综合运用各种政策工具，以创造积极的市场预期。Analysts expect that the end-April meeting is poised to introduce significant fiscal stimulus measures, potentially exceeding 1 trillion yuan ($137 billion) in scale.分析人士预计，4月底的会议将推出重大财政刺激措施，规模可能超过1万亿元人民币（1370亿美元）。"We expect incremental funds of 1.5 trillion yuan, or 1 percent of GDP, on top of the budget approved earlier this year. End-demand, especially consumption, should be more a focus than investment this time, given the nature of the tariff shock," Citi analysts said in a report on Monday.花旗分析师周一在一份报告中表示：“我们预计，在年初批准的预算基础上，新增资金将达到1.5万亿元人民币，占GDP的1%。鉴于关税冲击的性质，此次应该更多地关注终端需求，尤其是消费，而非投资。”China Galaxy Securities also said on Sunday in a report that the size of the new fiscal stimulus measures could be around 1.5 to 2 trillion yuan, with a particular emphasis on further strengthening policies to stimulate consumption.中国银河证券周日也在一份报告中表示，新的财政刺激措施规模可能在1.5万亿至2万亿元人民币左右，尤其强调进一步加强刺激消费的政策。In particular, with the goal of better offsetting the slowdown in external demand, the overall fiscal budget for consumption-boosting measures this year might be increased from the initially planned 300 billion yuan to a range of 700 billion yuan to 1 trillion yuan, said Feng Lin, executive director of the research and development department at Golden Credit Rating International.东方金诚国际信用评估有限公司研究发展部执行总监冯琳表示，为了更好地抵消外部需求放缓的影响，今年用于刺激消费措施的财政总预算可能会从最初计划的3000亿元人民币增加到7000亿至1万亿元人民币。China's annual exports to the US have been around $500 billion in recent years, which is equivalent to 7-8 percent of the China's domestic consumer goods consumption, according to Feng.冯琳表示，近年来，中国对美年出口额约为5000亿美元，相当于中国国内消费品消费的7%至8%。"This means that as long as domestic consumption is effectively stimulated, China is capable of absorbing the decline in exports to the US. Before the pandemic, the normal growth rate of the country's total retail sales of consumer goods was between 8 and 9 percent," Feng said.“这意味着，只要有效刺激国内消费，中国就有能力消化对美出口的下滑。疫情爆发前，中国社会消费品零售总额的正常增长率在8%到9%之间，”冯琳表示。Notably, any major fiscal policy in China requires going through legislative procedures. The Standing Committee of the National People's Congress, which has the power to approve budget adjustments, is scheduled to meet in Beijing from Sunday to Wednesday.值得注意的是，中国任何重大财政政策都需要经过立法程序。拥有预算调整审批权的全国人大常委会计划于本周日到周三在北京召开会议。"If any fiscal resolution indicated by the upcoming meeting is approved by the NPC Standing Committee, it would buttress Beijing's determination to achieve growth despite the trade hardships," Citi said.花旗银行表示：“如果即将召开的全国人大常委会会议中提出的任何财政决议获得批准，这将坚定中国政府在贸易摩擦中实现增长的决心。”Even if the upcoming meeting and the NPC Standing Committee session greenlight new fiscal stimulus measures, analysts said the details and timeline of the rollouts would be determined in a flexible manner, depending on the evolving economic dynamics.分析人士表示，即使即将召开的全国人大常委会会议和全国人大常委会会议批准新的财政刺激措施，这些措施的具体细节和时间表也将根据不断变化的经济形势灵活确定。For the previously announced government bonds in March, the country is expected to accelerate their issuance in the second quarter, and expedite the utilization of these funds to support concrete projects, said Zhang Jun, chief economist at China Galaxy Securities.中国银河证券首席经济学家章俊表示，对于此前宣布的3月份国债发行，预计国家将在第二季度加快发行，并加快资金用于支持具体项目。The anticipated introduction of the extra fiscal stimulus measures and accelerated implementation of the existing ones would "create a window of opportunity" for a corresponding level of liquidity support from the monetary policy side, Zhang said.章俊表示，预期中的额外财政刺激措施将出台，现有措施也将加快落实，这将为货币政策层面提供相应流动性支持“创造机会窗口”。China's central bank is expected to employ a combination of both quantitative and structural policy tools, with a reserve requirement ratio cut of around 20 basis points likely to be implemented on the heels of the end-April meeting, followed by a potential interest rate reduction around June. The government is also expected to introduce a range of structural monetary policies aimed at providing targeted relief to the foreign trade sector, as well as bolstering consumer demand and technological innovation, Zhang added.预计中国央行将结合运用数量型和结构性政策工具，在4月底会议后可能实施约20个基点的降准，随后可能在6月左右再度降息。章俊补充道，预计政府还将推出一系列结构性货币政策，旨在为外贸行业提供定向纾困，并提振消费需求和技术创新。Citi said in its report that, "Finding patience to play the long game, the end-April meeting will stick to the policy framework of 'high-quality development' and will not take an all-out approach."花旗在其报告中表示：“4月底的会议将秉持耐心，着眼长远，坚持‘高质量发展'的政策框架，不会采取全面举措。”stimulus/ˈstɪmjələs/n.刺激（措施）；促进因素reassess/ˌriːəˈses/v.重新评估；重新考虑buttress/ˈbʌtrəs/v.支持；加强liquidity/lɪˈkwɪdəti/n.流动性；资产变现能力

Episode Title: Sleep, Stress, and Exercise for Mental Health with Cognitive Neuroscientist, Justin Verlinden Description: In this episode of the Elevate Yourself podcast, Rob is joined by cognitive neuroscientist, Justin Verlinden, to explore the intersection of sleep, stress, and exercise on mental health. Justin provides valuable insights into how exercise-induced stress impacts the body and how sleep plays a crucial role in helping our bodies recover and recalibrate. Since Justin's last appearance on the show, he's been busy uncovering new findings in his field, and he's excited to share what he's learned. He dives into the science of exercise's effects on stress and how sleep can help us process and recover from it. He also touches on an important question: Does the timing of exercise impact sleep quality, and how does core temperature come into play? As we wrap up the episode, Justin answers rapid-fire questions, giving us a personal peek into his daily routines, insights, and how his thinking has evolved since his last visit. Justin's Bio: Justin Verlinden is a Cognitive Neuroscience PhD Candidate co-mentored by Dr. Lauren Whitehurst and Dr. Jessica Weafer (formerly at University of Kentucky, presently at Ohio State University). Whose research to-date has been centered on the following topics: Sleep as a treatment target for at-risk drinking Sex differences in the relationship between sleep and alcohol use Next-day consequences of drinking on cognition With the help of his mentors and collaborators, he has received training in and utilized a variety of research modalities and skills throughout his career, including: Intravenous alcohol administration Alcohol skin biosensors Polysomnography Actigraphy At-home diaries R programming Feel free to reach out to him via email (justinverlinden@uky.edu) or on IG (@_veezy13) if you would like to learn more about him or his work. He's always happy to nerd out over science :) Selected Publications: Verlinden, J.J., Moloney, M.E., Vsevolozhskaya, O.A., Whitehurst, L.N. and Weafer, J., 2025. Indirect effects of perceived stress and depression on the relationship between insomnia symptoms and hazardous drinking. Alcohol 123: 1-9. https://doi.org/10.1016/j.alcohol.2025.01.001 Verlinden, J.J., Moloney, M.E., Vsevolozhskaya, O.A., Ritterband, L.M., Winkle, F., and Weafer, J. 2023. Effect of a digital cognitive behavioral therapy for insomnia on sleep and alcohol consumption in heavy drinkers: A randomized pilot study. Alcohol Clinical and Experimental Research 47(12):2354-2365. https://doi.org/10.1111/acer.15209 Verlinden, J.J., Moloney, M.E., Whitehurst, L.N., and Weafer, J. 2022. Sex differences in the association between poor sleep quality and alcohol-related problems among heavy drinkers with insomnia. Frontiers in Behavioral Neuroscience 16:875168. https://doi.org/10.3389/fnbeh.2022.875168 Fadel, L.C., Patel, I.V., Romero, J., Tan, I., Kesler, S.R., Rao, V., Subasinghe, S.A., Ray, R.S., Yustein, J.T., Allen, M.J., Gibson, B.W., Verlinden, J.J., Fayn, S., Ruggiero, N., Ortiz, C., Hipskind, E., Feng, A., Iheanacho, C., Wang, A., and Pautler, R.G. 2022. A mouse holder for awake functional imaging in unanesthetized mice: Applications in 31P spectroscopy, manganese-enhanced magnetic resonance imaging studies, and resting-state functional magnetic resonance imaging. Biosensors 12(8): 616. https://doi.org/10.3390/bios12080616 The Elevate Yourself Podcast is brought to you in partnership with Athletic Brewing. Use code ELEVATE30 for 30% OFF your first online order at checkout!

What a great combination of sharing some hints along the way with a grand adventure, discovering the Way.Most of us have not had the almost mythic sounding breakthrough experiences of Master Kao-feng, and as a beginner, reading these enlightenment stories seems to raise an unrealistic training yardstick to jump over.Read the Journal while listening

When it comes to China, most Americans are mostly in the dark. Don't believe me? Just quiz your friends. Ask them to name the five largest cities in China. Or to tell you the difference between people in Fujian and Sichuan, or Beijing and Guangzhou? Or how many cars China exported last year.  Is China's economy booming on the back of record exports or reeling from a property meltdown and tanking consumer confidence? How many of us can say we know for sure. How many of us are in regular communication with people in China? Here to fill the void is Emily Feng, author of a tremendous new book called Let Only Red Flowers Bloom. Ms Feng brings to life the joys and sorrows, advances and setbacks of ordinary people in China. And she explains why, under Xi Jinping, people are encouraged to bloom red. 

JCO PO author Dr. Timothy Showalter at Artera and University of Virginia shares insights into his JCO PO article, “Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer” . Host Dr. Rafeh Naqash and Dr. Showalter discuss how multimodal AI as a prognostic marker in nonmetastatic castration-resistant prostate cancer may serve as a predictive biomarker with high-risk patients deriving the greatest benefit from treatment with apalutamide. TRANSCRIPT  Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations where we'll bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast Editor for JCO Precision Oncology and assistant professor at the OU Health Stephenson Cancer Center at the University of Oklahoma. Today, we are excited to be joined by Dr. Timothy Showalter, Chief Medical Officer at Artera and professor of Radiation Oncology at the University of Virginia and author of the JCO Precision Oncology article entitled, “Digital Pathology Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase 3 Trial in Men with Non-Metastatic Castration Resistant Prostate Cancer.” At the time of this recording, our guest's disclosures will be linked in the transcript. Dr. Showalter, it's a pleasure to have you here today. Dr. Timothy Showalter: It's a pleasure to be here. Thanks for having me. Dr. Rafeh Naqash: I think this is going to be a very interesting discussion, not just from a biomarker perspective, but also in terms of how technologies have evolved and how we are trying to stratify patients, trying to escalate or deescalate treatments based on biomarkers. And this article is a good example of that. One of the things I do want to highlight as part of this article is that Dr. Felix Feng is the first author for this article. Unfortunately, Dr. Felix Feng passed away in December of 2024. He was a luminary in this field of prostate cancer research. He was also the Chair of the NRG GU Committee as well as Board of Directors for RTOG Foundation and has mentored a lot of individuals from what I have heard. I didn't know Dr. Feng but heard a lot about him from my GU colleagues. It's a huge loss for the community, but it was an interesting surprise for me when I saw his name on this article as I was reviewing it. Could you briefly talk about Dr. Feng for a minute and how you knew him and how he's been an asset to the field? Dr. Timothy Showalter: Yeah. I'm always happy to talk about Felix whenever there's an opportunity. You know, I was fortunate to know Felix Feng for about 20 years as we met during our residency programs through a career development workshop that we both attended and stayed close ever since. And you know, he's someone who made an impact on hundreds of lives of cancer researchers and other radiation oncologists and physicians in addition to the cancer patients he helped, either through direct clinical care or through his innovation. For this project in particular, I first became involved soon after Felix had co-founded Artera, which is, you know the company that developed this. And because Felix was such a prolific researcher, he was actually involved in this and this research project from all different angles, both from the multimodal digital pathology tool to the trial itself and being part of moving the field forward in that way. It's really great to be able to sort of celebrate a great example of Felix's legacy, which is team science, and really moving the field forward in terms of translational projects based on clinical trials. So, it's a great opportunity to highlight some of his work and I'm really happy to talk about it with you. Dr. Rafeh Naqash: Thanks, Tim. Definitely a huge loss for the scientific community. And I did see a while back that there was an international symposium organized, showcasing his work for him to talk about his journey last year where more than 200, 250 people from around the globe actually attended that. That speaks volumes to the kind of impact he's had as an individual and impact he's had on the scientific side of things as well. Dr. Timothy Showalter: Yes. And we just had the second annual Feng Symposium the day before ASCO GU this year with, again, a great turnout and some great science highlighted, as well as a real focus on mentorship and team science and collaboration. Dr. Rafeh Naqash: Thank you so much for telling us all about that. Now going to what you guys published in JCO Precision Oncology, which is this article on using a biomarker approach to stratify non-metastatic prostate cancer using this artificial intelligence based H&E score. Could you tell us the background for what started off this project? And I see there is a clinical trial data set that you guys have used, but there's probably some background to how this score or how this technology came into being. So, could you superficially give us an idea of how that started? Dr. Timothy Showalter: Sure. So, the multimodal AI score was first published in a peer reviewed journal back in 2022 and the test was originally developed through a collaboration with the Radiation Therapy Oncology Group or Energy Oncology Prostate Cancer Research Team. The original publication describes development and validation of a risk stratification tool designed to predict distant metastasis and prostate cancer specific mortality for men with localized prostate cancer. And the first validation was in men who were treated with definitive radiation therapy. There have been subsequent publications in that context and there's a set of algorithms that have been validated in localized prostate cancer and there's a test that's listed on NCCN guidelines based on that technology. The genesis for this paper was really looking at extending that risk stratification tool that was developed in localized prostate cancer to see if it could one, validate in a non-metastatic castrate refractory prostate cancer population for patients enrolled on the SPARTAN trial. And two, whether there was a potential role for the test output in terms of predicting benefit from apalutamide for patients with non-metastatic prostate cancer. For patients who are enrolled on the SPARTAN study, almost 40% of them had H&E stain biopsy slide material available and were eligible to be included in this study. Dr. Rafeh Naqash: Going a step back to how prostate cancer, perhaps on the diagnostic side using the pathology images is different as you guys have Gleason scoring, which to the best of my knowledge is not necessarily something that most other tumor types use. Maybe Ki-67 is somewhat of a comparison in some of the neuroendocrine cancers where high Ki-67 correlates with aggressive biology for prognosis. And similarly high Gleason scores, as we know for some of the trainees, correlates with poor prognosis. So, was the idea behind this based on trying to stratify or sub-stratify Gleason scoring further, where you may not necessarily know what to do with the intermediate high Gleason score individual tumor tissues? Dr. Timothy Showalter: Well, yeah. I mean, Gleason score is a really powerful risk stratification tool. As you know, our clinical risk groupings are really anchored to Gleason scores as an important driver for that. And while that's a powerful tool, I think, you know, some of the original recognition for applying computer vision AI into this context is that there are likely many other features located in the morphology that can be used to build a prognostic model. Going back to the genesis of the discovery project for the multimodal AI model, I think Felix Feng would have described it as doing with digital pathology and computer vision AI what can otherwise be done with gene expression testing. You know, he would have approached it from a genomic perspective. That's what the idea was. So, it's along the line of what you're saying, which is to think about assigning a stronger Gleason score. But I think really more broadly, the motivation was to come up with an advanced complementary risk stratification tool that can be used in conjunction with clinical risk factors to help make better therapy recommendations potentially. So that was the motivation behind it. Dr. Rafeh Naqash: Sure. And one of the, I think, other important teaching points we try to think about, trainees of course, who are listening to this podcast, is trying to differentiate between prognostic and predictive scores. So, highlighting the results that you guys show in relation to the MMAI score, the digital pathology score, and outcomes as far as survival as well as outcomes in general, could you try to help the listeners understand the difference between the prognostic aspect of this test and the predictive aspect of this test? Dr. Timothy Showalter: So let me recap for the listeners what we found in the study and how it kind of fits into the prognostic and the predictive insights. So, one, you know, as I mentioned before, this is ultimately a model that was developed and validated for localized prostate cancer for risk stratification. So, first, the team looked at whether that same tool developed in localized prostate cancer serves as a prognostic tool in non-metastatic castrate-refractory prostate cancer. So, we applied the tool as it was previously developed and identified that about 2/3 of patients on the SPARTAN trial that had specimens available for analysis qualified as high risk and 1/3 of patients as either intermediate or low risk, which we called in the paper ‘non-high risk'. And we're able to show that the multimodal AI score, which ranges from 0 to 1, and risk group, was associated with metastasis free survival time to second progression or PFS 2 and overall survival. And so that shows that it performs as a prognostic tool in this setting. And this paper was the first validation of this tool in non-metastatic castrate-refractory prostate cancer. So, what that means to trainees is basically it helps you understand how aggressive that cancer is or better stratify the risk of progression over time. So that's the prognostic performance. Dr. Rafeh Naqash: Thank you for trying to explain that. It's always useful to get an example and understand the difference between prognostic and predictive. Now again, going back to the technology, which obviously is way more complicated than the four letter word MMAI, I per se haven't necessarily done research in this space, but I've collaborated with some individuals who've done digital pathology assessments, and one of the projects we worked on was TIL estimation and immune checkpoint related adverse events using some correlation and something that one of my collaborators had sent to me when we were working on this project as part of this H&E slide digitalization, you need color deconvolution, you need segmentation cell profiling. Superficially, is that something that was done as part of development of this MMAI score as well? Dr. Timothy Showalter You need a ground truth, right? So, you need to train your model to predict whatever the outcome is. You know, if you're designing an AI algorithm for Ki-67 or something I think you mentioned before, you would need to have a set of Ki-67 scores and train your models to create those scores. In this case, the clinical annotation for how we develop the multimodal AI algorithm is the clinical endpoints. So going back to how this tool was developed, the computer vision AI model is interpreting a set of features on the scan and what it's trying to do is identify high risk features and make a map that would ultimately predict clinical outcomes. So, it's a little bit different than the many digital pathology algorithms where the AI is being trained to predict a particular morphological finding. In this case, the ground truth that the model is trained to predict is the clinical outcome. Dr. Rafeh Naqash: Sure. And from what you explained earlier, obviously, tumors that had a high MMAI score were the ones that were benefiting the most from the ADT plus the applausive. Is this specific for this androgen receptor inhibitor or is it interchangeable with other inhibitors that are currently approved? Dr. Timothy Showalter: That's a great question and we don't know yet. So, as you're alluding to, we did find that the MMAI risk score was predictive for benefit from apalutamide and so it met the statistical definition of having a significant interaction p value so we can call it a predictive performance. And so far, we've only looked in this population for apalutamide. I think you're raising a really interesting point, which is the next question is, is this generalizable to other androgen receptor inhibitors? There will be future research looking at that, but I think it's too early to say. Just for summary, I think I mentioned before, there are about 40% of patients enrolled on the SPARTAN study had specimens available for inclusion in this analysis. So, the SPARTAN study did show in the entire clinical trial set that patients with non-metastatic castrate-refractory prostate cancer benefited from apalutamide. The current study did show that there seems to be a larger magnitude of benefit for those patients who are multimodal AI high risk scores. And I think that's very interesting research and suggests that there's some interaction there. But I certainly would want to emphasize that we have not shown that patients with intermediate or low risk don't benefit from apalutamide. I think we can say that the original study showed that that trial showed a benefit and that we've got this interesting story with multimodal AI as well. Dr. Rafeh Naqash: Sure. And I think from a similar comparison, ctDNA where ctDNA shows prognostic aspects, I treat people with lung cancer especially, and if you're ctDNA positive at a 3 to 4-month period, likely chances of you having a shorter disease-free interval is higher. Same thing I think for colorectal cancers. And now there are studies that are using ctDNA as an integral biomarker to stratify patients positive/negative and then decide on escalation/de-escalation of treatment. So, using a similar approach, is there something that is being done in the context of the H&E based stratification to de-intensify or intensify treatments based on this approach? Dr. Timothy Showalter: You're hitting right on the point in the most promising direction. You know, as we pointed out in the manuscript, one of the most exciting areas as a next step for this is to use a tool like this for stratification for prospective trials. The multimodal AI test is not being used currently in clinical trials of non-metastatic castrate-refractory prostate cancer, which is a disease setting for this paper. There are other trials that are in development or currently accruing where multimodal AI stratification approach is being taken, where you see among the high-risk scores, at least in the postoperative setting for a clinical trial that's open right now, high risk score patients are being randomized to basically a treatment intensification question. And then the multimodal AI low risk patients are being randomized to a de-intensification experimental arm where less androgen deprivation therapy is being given. So, I think it's a really promising area to see, and I think what has been shown is that this tool has been validated really across the disease continuum. And so, I think there are opportunities to do that in multiple clinical scenarios. Dr. Rafeh Naqash: Then moving on to the technological advancements, very fascinating how we've kind of evolved over the last 10 years perhaps, from DNA based biomarkers to RNA expression and now H&E. And when you look at cost savings, if you were to think of H&E as a simpler, easier methodology, perhaps, with the limitations that centers need to digitalize their slides, probably will have more cost savings. But in your experience, as you've tried to navigate this H&E aspect of trying to either develop the model or validate the model, what are some of the logistics that you've experienced can be a challenge? As we evolve in this biomarker space, how can centers try to tackle those challenges early on in terms of digitalizing data, whether it's simple data or slides for that matter? Dr. Timothy Showalter: I think there's two main areas to cover. One, I think that the push towards digitalization is going to be, I think, really driven by increasing availability and access to augmentative technologies like this multimodal AI technology where it's really adding some sort of a clinical insight beyond what is going to be generated through routine human diagnostic pathology. I think that when you can get these sorts of algorithms for patient care and have them so readily accessible with a fast turnaround time, I think that's really going to drive the field forward. Right now, in the United States, the latest data I've seen is that less than 10% of pathology labs have gone digital. So, we're still at an early stage in that. I hope that this test and similar ones are part of that push to go more digital. The other, I think, more interesting challenge that's a technical challenge but isn't about necessarily how you collect the data, but it certainly creates data volume challenges, is how do you deal with image robustness and sort of translating these tools into routine real-world settings. And as you can imagine, there's a lot of variation for staining protocols, intensity scanner variations, all these things that can affect the reliability of your test. And at least for this research group that I'm a part of that has developed this multimodal AI tool can tell you that the development is sophisticated, but very data and energy intensive in terms of how to deal with making a tool that can be consistent across a whole range of image parameters. And so that presents its own challenges for dealing with a large amount of compute time and AI cycles to make robust algorithms like that. And practically speaking, I think moving into other diseases and making this widely available, the size of data required and the amount of cloud compute time will be a real challenge. Dr. Rafeh Naqash: Thank you for summarizing. I can say that definitely, you know, this is maybe a small step in prostate cancer biomarker research, but perhaps a big step in the overall landscape of biomarker research in general. So definitely very interesting. Now, moving on to the next part of the discussion is more about you as a researcher, as an individual, your career path, if you can summarize that for us. And more interestingly, this intersection between being part of industry as well as academia for perhaps some of the listeners, trainees who might be thinking about what path they want to choose. Dr. Timothy Showalter: Sure. So, as you may know, I'm a professor at the University of Virginia and I climbed the academic ladder and had a full research grant program and thought I'd be in academia forever. And my story is that along the way, I kind of by accident ended up founding a medical device company that was called Advaray and that was related to NCI SBIR funding. And I found myself as a company founder and ultimately in that process, I started to learn about the opportunity to make an impact by being an innovator within the industry space. And that was really the starting point for me. About four years ago, soon after Felix Feng co-founded Artera, he called me and told me that he needed me to join the company. For those who were lucky to know Felix well, at that very moment, it was inevitable that I was going to join Artera and be a part of this. He was just so persuasive. So, I will say, you know, from my experience of being sort of in between the academic and industry area, it's been a really great opportunity for me to enter a space where there's another way of making an impact within cancer care. I've gotten to work with top notch collaborators, work on great science, and be part of a team that's growing a company that can make technology like this available. Dr. Rafeh Naqash: Thank you so much, Tim, for sharing some of those thoughts and insights. We really appreciate you discussing this very interesting work with us and also appreciate you submitting this to JCO Precision Oncology and hopefully we'll see more of this as this space evolves and maybe perhaps bigger more better validation studies in the context of this test. Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

Chen Feng is the Head of Research at Autonomys and an Associate Professor and Principal's Research Chair in Blockchain at the University of British Columbia (Okanagan Campus). His research focuses on applying advanced theories from information and coding theory, stochastic processes, and optimization to develop more effective communication networks, with a special emphasis on blockchain technology.

Chen Feng is the Head of Research at Autonomys and an Associate Professor and Principal's Research Chair in Blockchain at the University of British Columbia (Okanagan Campus). His research focuses on applying advanced theories from information and coding theory, stochastic processes, and optimization to develop more effective communication networks, with a special emphasis on blockchain technology.

Increasing numbers of people are surviving stroke but with motor impairments that can contribute substantially to long-term disability. Transcranial direct current stimulation has shown promise in reducing motor impairment when combined with rehabilitation therapy. Sarah Passey talks to Wayne Feng (Duke University School of Medicine, Durham, NC, USA) about his latest trial, TRANSPORT2, which assesses transcranial direct current stimulation in combination with modified constraint-induced movement therapy.Read the full article:https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00044-4/fulltext?dgcid=buzzsprout_tlv_podcast_16-04-25_laneurContinue this conversation on social!Follow us today at...https://thelancet.bsky.social/https://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

QUBIT AI, Recall This, Defender, Tycoon, Slopsquatting, Feng Mengleng, Aaran Leyland, and more, on the Security Weekly News. Visit https://www.securityweekly.com/swn for all the latest episodes! Show Notes: https://securityweekly.com/swn-468

QUBIT AI, Recall This, Defender, Tycoon, Slopsquatting, Feng Mengleng, Aaran Leyland, and more, on the Security Weekly News. Show Notes: https://securityweekly.com/swn-468

QUBIT AI, Recall This, Defender, Tycoon, Slopsquatting, Feng Mengleng, Aaran Leyland, and more, on the Security Weekly News. Visit https://www.securityweekly.com/swn for all the latest episodes! Show Notes: https://securityweekly.com/swn-468

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

QUBIT AI, Recall This, Defender, Tycoon, Slopsquatting, Feng Mengleng, Aaran Leyland, and more, on the Security Weekly News. Show Notes: https://securityweekly.com/swn-468

Listen to today's podcast... Getting a full night's sleep is up there on the list of things that can make you an energetic, happier person. That quality and quantity can be impacted by poor feng shui in your bedroom. By being aware of some of the principles of feng shui, your bedroom can promote healing, love, and energy. Take One Action Today To Build Your #Resiliency!      So Here are today's Tips For Building Resiliency and Celebrating Feng Shui Awareness Day: Meeting the feng shui bed guidelines starts with a solid headboard, good mattress, good frame height, and no storage underneath. Choose Your Bedroom to be at the back-end of your home. The back-end of our homes are usually much quieter and your sleep is less likely to be disrupted. Position your head so that you can see the door and have your headboard against the wall. This gives you a subtle sense of security that'll help you fall asleep easier. The feng shui commanding position is the area furthest diagonally from the door, but not in line with it. Only have things that bring you joy and help your energy Work and sleep don't mix, so avoid work-related furniture in the bedroom. Get rid of “light pollution” that causes sleepless nights. Use black out curtains if necessary. Remove all electronics from easy-access to your bed, and you can find your sleep quality improve. Keep your bedroom free of clutter including underneath your bed. A clean and organized bedroom is more visually relaxing and less likely to invoke frustration and agitation that lower your sleep quality. Feng shui is often misconstrued as a complicated, confusing process, however, just follow a few basic principles. Keep clutter at a minimum, have plenty of natural light and fill your home with rounded or curved furniture to allow energy to flow more freely throughout a space. Discover how to take small steps towards a healthier, happier, less-stressed you by visiting my website at worksmartlivesmart.com #mentalhealth #hr

NPR reporter Emily Feng lived in, and reported from, Beijing for years. But in 2022, the Chinese government told Feng, who was born in the United States to Chinese parents, that she couldn't return to the country. The experience prompted her to ask: What does it mean to be Chinese under Xi Jinping's government? Her new book Let Only Red Flowers Bloom explores this question through the lens of individuals who don't fit the government's ideal. In today's episode, Feng joins NPR's Ailsa Chang for a conversation about one of the central characters in the book, the way the Chinese government connects religion and ethnicity, and the personal impact of identity politics.To listen to Book of the Day sponsor-free and support NPR's book coverage, sign up for Book of the Day+ at plus.npr.org/bookofthedayLearn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

In this episode, Steve leads a discussion on the invasive Grass Carp. The guys go over the evolutionary history of grass carp and its relatives, its biology, its introduction to The Great Lakes region, why people are concerned, and anything interesting Steve found out about it.There are a lot more interesting fish topics that we can explore in the future, at least while Steve is researching fish. Enojy the episode!This episode was recorded on February 24, 2025 at JP Nicely Memorial Park in West Falls, NY.Episode Notes and LinksSeagulls are fish.Common Carp are invasive and cause environmental damage. The guys didn't get this right. For shame!Sponsors and Ways to Support UsGumleaf Boots, USA (free shipping for patrons)Thank you to Always Wandering Art (Website and Etsy Shop) for providing the artwork for many of our episodes.Support us on Patreon.Check out the Field Guides merch at our Teespring store. It's really a great deal: you get to pay us to turn your body into a billboard for the podcast!Works CitedChapman, D.C., Davis, J.J., Jenkins, J.A., Kocovsky, P.M., Miner, J.G., Farver, J. and Jackson, P.R., 2013. First evidence of grass carp recruitment in the Great Lakes Basin. Journal of Great Lakes Research, 39(4), pp.547-554.Mitchell, A.J. and Kelly, A.M., 2006. The public sector role in the establishment of grass carp in the United States. Fisheries, 31(3), pp.113-121.Wang, Y., Lu, Y., Zhang, Y., Ning, Z., Li, Y., Zhao, Q., Lu, H., Huang, R., Xia, X., Feng, Q.I. and Liang, X., 2015. The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation. Nature genetics, 47(6), pp.625-631.Wu, C.S., Ma, Z.Y., Zheng, G.D., Zou, S.M., Zhang, X.J. and Zhang, Y.A., 2022. Chromosome-level genome assembly of grass carp (Ctenopharyngodon idella) provides insights into its genome evolution. BMC genomics, 23(1), p.271.Photo CreditPeter Halasz (User:Pengo), Melbourne, CC BY-SA 3.0 Grass carp (Ctenopharyngodon idella) at Tropicarium Budapest. No changes made to photo

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes "Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer" by Felix Y. Feng, et al published January 31, 2025. Come back for the next episode where JCO Precision Oncology Conversations host, Dr. Rafeh Naqash interviews the author of the JCO PO article discussed, Dr. Tim Showalter. TRANSCRIPT Natalie DelRocco: Hello and welcome to JCO Precision Oncology Article Insights. I'm your host Natalie Del Rocco. Today, we'll be discussing the article, “Digital Pathology-Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer.” We will also be discussing the accompanying editorial, “Leveraging Artificial Intelligence to Improve Risk Stratification in Nonmetastatic Castration-Resistant Prostate Cancer.” So, we're going to start by summarizing the original report and then we'll jump into a few of the high-level interpretations that were supplied by the editorial.   The original report by Feng et. al. describes the application of multimodal artificial intelligence to data collected on a nonmetastatic castration-resistant prostate cancer. We will call this disease moving forward NMCRPC, a Clinical Trial. So, we're looking at data from an NMCRPC clinical trial. The SPARTAN trial was a randomized phase three trial and this study compared metastasis-free survival as the primary endpoint for those treated with traditional androgen deprivation therapy or ADT to those treated with androgen deprivation therapy plus apalutamide. Other secondary endpoints included progression-free survival and overall survival, but the primary endpoint there was metastasis-free survival or MFS. This study found that the addition of apalutamide resulted in a significantly longer median metastasis-free survival compared to androgen deprivation therapy alone. And we should note that this is a double-blind placebo-controlled trial. In the overall study, 1,207 patients participated and over the course of this study histopathology slides were collected and they were digitized for future use. And that future use is what we are going to be discussing today.  The authors do note that there are currently no good biomarkers for use in NMCRPC. The authors seem to be inspired by the ArteraAI prostate test, which was a recent application of multimodal artificial intelligence models. But in localized prostate cancer as opposed to NMCRPC, the authors constructed a multimodal artificial intelligence model or an MMAI model. They applied this to the SPARTAN trial with the intention of developing a risk score that could be used for risk stratification in NMCRPC. And we should note here that multimodal artificial intelligence or MMAI is a broad class of artificial intelligence models, and they can analyze different types of data at one time, hence the term multimodal. So in this example, the author's primary data source of interest were those digitized histopathology images because histopathology tells you a lot about NMCRPC. The authors though also wanted their model to consider traditional clinical factors that are known to be prognostic such as Gleason score, tumor stage, PSA level, and age. So those two different types of data, those histopathology images and that traditional clinical data are the two different types of data that make this model multimodal. So we should note here importantly, after dropping missing data, 420 patients contribute to this model, the MMAI model.  The authors generate a risk score from this MMAI model and they categorize that risk score into low, intermediate, and high risk groups using clinical knowledge. The authors found in their results that an increase in this MMAI risk score was associated with an increased hazard of metastasis-free survival event with a hazard ratio from a Cox proportional hazards model of 1.72. To summarize how the authors arrived here, they derived a risk score from this MMAI model which incorporates both imaging and regular data. They plugged this risk score into a Cox proportional hazards mode,l modeling metastasis-free survival and they found that an increase in that MMAI based risk score is associated with increased hazard of metastasis-free event with a hazard ratio of 1.72, which is quite large. Additionally, the risk score seemed to be associated with PFS2 and OS, which were two of the secondary endpoints from the SPARTAN clinical trial, though the effect sizes were more modest. Those are the highlights from the original report, the methods and the results.  The accompanying editorial notes that both histopathology and Gleason score specifically are very critical to understanding prostate cancer, and Gleason score alone is not sufficient to summarize the complexity of the disease, although it is a well validated prognostic factor for prostate cancer. So this makes MMAI an excellent tool in the setting described by the authors. We have an existing prognostic factor that doesn't describe the entire picture of the disease by itself and so we can use those digitized histopathology slides to help bolster our understanding and provide the model more information. MMAI allows you to do this because it can take in different types of data. So that was the main conclusion of the editorial.  They also summarize a number of recent validations of MMAI models in prostate cancer research, noting that it will be an important tool for risk stratification and has already been shown to outperform classical techniques. The editorial though does highlight a number of weaknesses of this paper, limitations and I think the most important one to highlight, and we touched on this earlier, is that 420 patients from the SPARTAN clinical trial contributed to the development of this MMAI score. That is a small proportion of the roughly 1200 patients that did participate in the SPARTAN clinical trial. So we have a small subgroup analysis that can be limiting and this model will need to be validated in a broader population in the future.   Thank you for listening to JCO Precision Oncology Article Insights. Don't forget to give us a rating or a review and be sure to subscribe so that you never miss an episode. You can find all ASCO shows at asco.org/podcasts.    The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.      

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Text Me!Episode 217: Using House Therapy and Feng Shui to Support Your Sobriety w/ Amy Babish In episode 217 of the Sober Vibes podcast, Courtney Andersen welcomes Amy Babish to the show and the ladies discuss using Feng Shui to support your Sobriety. As well as ancestral patterns beyond the genetics of addiction.Amy Babish, MA, LPC, ATR-BC, is a somatic expert, house therapist (Feng Shui), Alchemical Family & Systems Constellations facilitator, and licensed therapist with over 20 years of experience. She helps people who've plateaued in therapy and mindset work feel at home in themselves, their bodies, homes, lives, and their lineage. Amy guides you to transmute stuck energy and dissolve intergenerational patterns into clarity, alignment, and a sense of profound belonging. She hosts The Soulful Visionary Podcast, where guests receive attuned processes aligning body, space, and legacy.What you will learn in this episode:• Feng shui principles can help remove stagnant energy associated with drinking patterns• The "Taoist trilogy" includes human, cosmic, and earthbound luck—all affecting recovery• Command position bedroom arrangement helps you see challenges before they arrive• Moving 27 things in your space creates significant energetic shifts• Ancestral constellation work uncovers patterns beyond genetics that influence addictionThank you to our Sponsor:As a show listener, you receive 20% off your order with EXACT NATURE. Make sure to check them out and support the show. Click here to shop and save 20% off with code "SV20. Free shipping on all orders! Listen to episode 129 with Thomas White to learn more about CBD.Resources Mentioned:Simple Shui BookConnect with Amy:WebsiteInstagramFollow Courtney for More Inspiration:Website → www.courtneyrecovered.comRemember: You are strong. You are capable. You are not alone. Keep thriving! Thank you for listening!Join the Soberity Circle today with a 4-day Free trial. Ready to thrive in your alcohol-free life? Sober Vibes: A Guide to Thriving in Your First Three Months Without Alcohol is your step-by-step guide to navigating early sobriety with confidence.Grab your copy today!Join Sober Vibes Patreon for exclusive content. (Just $8/month!) Thank you for listening! Help the show by Rating, Reviewing, and/or Subscribing to the Sober Vibes Podcast. Connect w/ Courtney:InstagramJoin the Sobriety Circle Apply for 1:1 CoachingOrder the Sober Vibes Book

Imagine changing your desk direction and suddenly tripling your contract, or decluttering and watching opportunities flood in. Marie Diamond, the feng shui master from The Secret, is here to talk about how your home is literally a vision board that can transform your entire life. Marie shares how the colors, images, and even the direction you face can manifest your dreams. Trust me, by the end of this episode, you'll be running around your house, moving furniture, and creating space for the magic you want to attract. In This Episode You Will Learn How your Bedroom design critically influences personal manifestation. Feng shui works for everyone, not just believers. Small home changes that trigger massive life shifts. The connection between your vision board and living spaces. Resources + Links Sign up for a one-dollar-per-month trial period at shopify.com/monahan Download the CFO's Guide to AI and Machine Learning at NetSuite.com/MONAHAN. Want to do more and spend less like Uber, 8x8, and Databricks Mosaic? Take a free test drive of OCI at oracle.com/MONAHAN. Get 10% off your first Mitopure order at timeline.com/CONFIDENCE. Get 15% off your first order when you use code CONFIDENCE15 at checkout at jennikayne.com. Call my digital clone at 201-897-2553!  Visit heathermonahan.com Sign up for my mailing list: heathermonahan.com/mailing-list/  Overcome Your Villains is Available NOW! Order here: https://overcomeyourvillains.com  If you haven't yet, get my first book Confidence Creator Follow Heather on Instagram & LinkedIn

Forget about the original “The Dating Game,” not to mention “The All-New Dating Game” and “The Celebrity Dating Game.” This is director Violet Du Feng's “The Dating Game,” which just had its world premiere at the 2025 Sundance Film Festival. Of course, this is a documentary not a Chuck Barris game show and, like Violet's previous film, the sublime “Hidden Letters,” which was shortlisted for an Academy Award, her version explores the topic with depth, insight, and humor.   Joining Ken for another of our in-person Sundance Film Festival interviews, along with the film's Academy Award-winning producer, Joanna Natasegara (“The White Helmets”), Violet discusses the similarities and differences between “Hidden Letters” and “The Dating Game.” The film delves into the world of dating for young Chinese men, who face immense challenges in a country where there are 30 million more men than women due to China's former One Child Policy. The film's compelling participants include the highly sought after but somewhat cheesy dating coach Hao and his three clients, as well as Hao's wife, Wen, also a dating coach. When, in one scene, Wen confronts Hao about their own marriage, the plot thickens. No game show can match that drama.   Follow: @violetdufeng and @joanna_film on Instagram and @VioletFilms @topdocspod on Instagram and X    The Presenting Sponsor of "Top Docs" is Netflix.

The fast-evolving artificial intelligence technology is expected to spearhead an industrial revolution and expedite the development of China's autonomous and intelligent connected vehicles, as AI is emerging as a critical strategic opportunity for the automotive industry, said national lawmakers, political advisers and experts. 快速演进的人工智能技术有望引领一场产业革命，并加速中国自动驾驶和智能网联汽车的发展。随着人工智能成为汽车行业的关键战略机遇，全国人大代表、政协委员及专家表示，中国需加快推动自动驾驶技术的大规模生产和商业化。 As China is accelerating steps to advance the mass production and commercialization of self-driving vehicles, more efforts should be made to improve the regulations and standards for autonomous driving, speed up the construction of intelligent transportation infrastructure, and expand the testing and application for autonomous vehicles in a wider range of scenarios, they added. 随着中国加速推进自动驾驶汽车的量产和商业化，专家建议进一步加强自动驾驶法规和标准建设，加快智能交通基础设施布局，并扩大自动驾驶在更广泛场景下的测试和应用。 Their comments follow this year's Government Work Report which stated that under the AI Plus initiative, China will support the extensive application of large-scale AI models and vigorously develop new-generation intelligent terminals and smart manufacturing equipment, including intelligent connected new energy vehicles. 这一观点呼应了今年《政府工作报告》中提出的“人工智能+”行动。报告指出，中国将支持大规模人工智能模型的应用推广，并大力发展新一代智能终端和智能制造装备，包括智能网联新能源汽车。 He Xiaopeng, chairman and CEO of Chinese electric vehicle maker Xpeng Motors, said a transformative AI era is approaching, and AI will accelerate the arrival of self-driving vehicles and even driverless vehicles. He emphasized that his company has continued to invest in AI and launched its self-developed AI-powered chips to enhance the intelligent driving capabilities of vehicles. 中国电动汽车制造商小鹏汽车董事长兼CEO何小鹏表示，人工智能变革时代即将到来，AI将加速自动驾驶甚至无人驾驶汽车的落地。他强调，小鹏汽车持续投入AI研发，并推出自研的人工智能芯片以提升车辆的智能驾驶能力。 The Xpeng CEO, who is also a deputy to the 14th National People's Congress, China's top legislature, said he believes that 2025 will mark a significant turning point in intelligent driving. With the continuous advancements and breakthroughs in core technologies such as algorithms, sensors and computing platforms, it is appropriate to bolster the mass production of Level 3 autonomous driving technology, he added. 何小鹏同时也是全国人大代表。他认为，2025年将是智能驾驶的重要转折点。随着算法、传感器和计算平台等核心技术的持续突破，推动三级（L3）自动驾驶技术量产是恰当时机。 Autonomous driving is categorized from Level 0 to Level 5. The higher the level, the more intelligent the technology and the lesser the involvement of humans. Level 3 refers to conditional automation, which allows vehicles to perform autonomous driving tasks under certain conditions. Such vehicles have "environmental detection" capabilities and can make some informed decisions, but are still subject to a human override. 自动驾驶技术分为0至5级，级别越高，技术智能化程度越高，人类参与度越低。三级自动驾驶属于“有条件自动化”，允许车辆在特定条件下自主完成驾驶任务。此类车辆具备“环境感知”能力，可做出部分决策，但仍需人类接管。 "Xpeng is planning to roll out its Level 3 capabilities in the second half of the year," He said, adding that by 2026, the company aims to explore Level 4 (high automation) capabilities, including fully driverless parking. Level 4 vehicles can intervene if there is a system failure and do not require human assistance in most circumstances. However, a manual override option is still available. “小鹏计划在今年下半年推出三级自动驾驶功能，”何小鹏表示，到2026年，公司计划探索四级（高度自动化）技术，包括完全无人泊车功能。四级车辆在系统故障时可主动干预，多数情况下无需人工辅助，但仍保留人工接管选项。 Feng Xingya, chairman of automobile manufacturer GAC Group, said, "The advancements in AI technology are becoming the core driving force bolstering the development of intelligent connected vehicles, and the application of AI will help reshape the automotive industry." AI is reshaping the intelligent experience of automobiles --- from intelligent driving to human-machine interaction --- and driving the transformation of automobiles toward "intelligent terminals", said Feng, who is also a national lawmaker. 广汽集团董事长冯兴亚表示：“人工智能技术进步正成为支撑智能网联汽车发展的核心动力，AI应用将重塑汽车产业。”冯兴亚同时也是全国人大代表。他指出，AI正在重塑汽车的智能化体验——从智能驾驶到人机交互——并推动汽车向‘智能终端'转型。 Looking ahead, GAC will promote the iteration of advanced intelligent driving and AI models, while speeding up the application of AI in fields such as automobile research and development, manufacturing and marketing, he added. While highlighting the significance of bolstering the commercialization of self-driving technology, Feng said that autonomous driving serves as the core technology of intelligent connected vehicles and a vital link in intelligent transportation. 冯兴亚透露，未来广汽将推动高阶智能驾驶和AI模型的迭代，同时加速AI在汽车研发、制造和营销等领域的应用。他还强调，自动驾驶是智能网联汽车的核心技术，也是智能交通的关键环节。 GAC is among the first carmakers to test Level 3 autonomous vehicles on public roads, and it plans to mass produce these vehicles this year. Feng suggested revising the Road Traffic Safety Law to clarify the liabilities concerning autonomous vehicles and accelerating the research and establishment of a specific law related to intelligent driving. 广汽是国内首批在公开道路测试三级自动驾驶车辆的车企，并计划今年实现量产。冯兴亚建议修订《道路交通安全法》，明确自动驾驶车辆的责任划分，并加快研究制定智能驾驶专门法律。 China has introduced a series of policies to promote the development and commercialization of autonomous vehicles in recent years. According to the Ministry of Industry and Information Technology, the country supports the commercial application of Level 3 and above autonomous driving systems. Over 50 cities nationwide have released autonomous driving pilot demonstration policies, and stepped up efforts to expand the application scenarios of self-driving technology. 近年来，中国已推出一系列政策推动自动驾驶技术发展和商业化。据工业和信息化部，中国支持三级及以上自动驾驶系统的商业化应用。目前全国已有超50个城市发布自动驾驶试点示范政策，并加紧拓展自动驾驶技术的应用场景。 Wang Xianjin, vice-president and chief engineer of the China Academy of Transportation Sciences, said the testing and operation of self-driving vehicles has accelerated significantly in China, laying a good foundation for the commercialization of autonomous driving, a tech frontier in which all major economies are scrambling to establish a beachhead. 中国交通科学院副院长兼总工程师王先进表示，中国自动驾驶车辆的测试和运营已显著加速，为自动驾驶商业化奠定了良好基础。这一技术领域正成为全球主要经济体竞相布局的前沿。 Wang, who is also a national political adviser, called for efforts to speed up formulation and revision of policies and regulations supporting the commercial application of self-driving technology, and continuously expand the scale of pilot operations of autonomous vehicles in more cities. 王先进同时也是全国政协委员。他呼吁加快制定和修订支持自动驾驶技术商业化应用的政策法规，并持续扩大更多城市自动驾驶试点运营规模。 Lei Jun, founder, chairman and CEO of Xiaomi Corp and a national lawmaker, proposed establishing a national testing and verification system for autonomous vehicles. He stressed the need to accelerate the commercial mass production of self-driving vehicles, with the goal of supporting their use on highways, expressways and urban roads by 2026. 全国人大代表、小米集团创始人雷军建议建立国家级自动驾驶测试认证体系，并强调需加快自动驾驶汽车商业化量产，目标到2026年支持其在高速公路、快速路和城市道路上的应用。spearheadn. 先锋,先头部队vt.当…的先锋,带头scenariosn. 情节；剧本；方案iterationn. 反复demonstrationn. 表明;证明;示范

Karen is a professional feng shui consultant and healthy-lifestyle designer, educator, and the best-selling author of Move Your Stuff, Change Your Life and Make a Shift, Change Your Life. She coaches, trains, and empowers people to use a variety of techniques to enrich and improve all areas of their lives.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-x-zone-radio-tv-show--1078348/support.

Last time we spoke about the first Tientsin Incident. In September 1931, as tensions rose between China and Japan, Commander Zhang Xueliang enjoyed an opera in Beiping, unaware of the impending Mukden Incident. With senior commanders absent, Japanese forces quickly gained local support. Chiang Kai-shek ordered non-resistance, fearing conflict would ruin Northeast China. Meanwhile, Japanese officials plotted to install Puyi as a puppet emperor. Covert riots erupted in Tianjin, orchestrated by the Japanese, leaving the city in chaos as Zhang's forces struggled to maintain order against the well-armed attackers. In a tense standoff at Haiguang Temple, the Japanese military issued an ultimatum to Chinese security forces, citing threats to overseas Chinese. Wang Shuchang ordered a strategic withdrawal, but the Japanese escalated with artillery fire. Despite fierce resistance, the plainclothes attackers regrouped, leading to ongoing skirmishes. Amidst the chaos, Puyi was covertly extracted by Japanese forces, paving the way for the establishment of the puppet state of Manchukuo. Ultimately, Japan's aggression continued, deepening tensions in China.   #142 the Jinzhou Operation  Welcome to the Fall and Rise of China Podcast, I am your dutiful host Craig Watson. But, before we start I want to also remind you this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Perhaps you want to learn more about the history of Asia? Kings and Generals have an assortment of episodes on history of asia and much more  so go give them a look over on Youtube. So please subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry for some more history related content, over on my channel, the Pacific War Channel where I cover the history of China and Japan from the 19th century until the end of the Pacific War. When the Mukden Incident occurred, Zhang Xueliang was in Beiping serving in his capacity as the commander of the North China garrison. On the night of September 18, he was at the opera enjoying a performance by the famous singer Mei Lanfang. His deputies were also away from Shenyang: Wan Fulin was in Beiping, and Zhang Zuoxiang was attending his father's funeral in Jinzhou. With the absence of the senior provincial commanders during the Incident, the Japanese quickly gained cooperation from the acting commanders. In Shenyang, Yu Zhishan, the commander of the Eastern Borders Garrison, and in Changchun, acting provincial forces commander Xi Xia, both swiftly aligned themselves with the Japanese. Although the Northeastern Army had approximately 130,000 troops in the region compared to a Japanese force of 40,000 to 50,000, Chiang Kai-shek urgently issued a non-resistance order to the Northeastern troops, which Zhang Xueliang confirmed. It was actually his stance prior to September 18th, as there had been other incidents such as the Wanbaoshan Incident whereupon Zhang Xueliang sent a secret telegram to his subordinates starting on July 6, "If we go to war with Japan at this time, we will surely be defeated. If we lose, Japan will demand that we cede territory and pay compensation, and Northeast China will be ruined. We should avoid conflict as soon as possible and deal with it in the name of justice." A month after this Chiang Kai-Shek sent a telegram to Zhang Xueliang on August 16th "No matter how the Japanese army seeks trouble in Northeast China in the future, we should not resist and avoid conflict. My brother, please do not act out of anger and disregard the country and the nation. I hope you will follow my instructions." As the tensions between China and Japan increased on September 6th Zhang Xueliang sent this telegram to his subordinates "It has been found that the Japanese diplomatic situation is becoming increasingly tense. We must deal with everything and strive for stability. No matter how the Japanese try to cause trouble, we must be tolerant and not resist them to avoid causing trouble. I hope you will send a secret telegram to all your subordinates to pay close attention to this matter." Thus the Manchurian commanders were already well versed in what their stance would be. Chiang Kai-shek's hesitation to engage in combat is understandable; he was concerned about factions opposing him in South China, the potential reformation of the alliance between Feng Yuxiang and Yan Xishan in North China, and the threat posed by the CCP in Jiangxi, leaving him unable to confront another adversary. Zhang Xueliang's situation was also not as advantageous as it might seem. Although he commanded nearly 250,000 men, only 100,000 to 130,000 were stationed in the Northeast, with the remainder in Hebei. Both Chiang Kai-Shek and Zhang Xueliang most likely believed the League of Nations or the Wakatsuki government in Tokyo would restrain the occupiers eventually, so they were biding their time. According to Nelson Johnson, the American Minister in China, Counselor Yano of the Japanese Legation in Beiping had informal discussions with Zhang, suggesting that Jinzhou would inevitably succumb to the Japanese and that “the Tokyo Foreign Office would gain prestige and be better able to shape events to China's advantage if the Chinese avoided a clash by withdrawing voluntarily.” It was also implied that some of Zhang's supporters might be reinstated in official roles in the new government in Shenyang. Johnson concluded, “Chang is believed to have been led to his present decision by these inducements, along with the bitter hostility toward him at Nanking and the lack of support from that quarter.” In essence, Zhang was effectively coerced into non-resistance by both sides. Certainly, in December 1931, with no hope for international intervention and the Nanjing government in turmoil following Chiang Kai-shek's temporary resignation, Zhang's options were severely limited. The Kwantung Army received clear instructions not to move beyond the South Manchurian railway zone, which hindered the plans of Lt. Colonel Ishiwara Kanji, the architect of the Manchurian invasion. After securing the region around the South Manchurian railway, Ishiwara focused his attention on Jinzhou. Following the fall of Mukden, Jinzhou became the administrative headquarters and civil government of Zhang Xueliang, making it a focal point for Chinese forces. Jinzhou is the southernmost part of Liaoning province, directly enroute to Shanhaiguan, the critical pass that separates Manchuria from China proper. It was the furthest point Zhang Xueliang could establish an HQ while still holding foot within Manchuria and thus became the defacto “last stand” or “guanwai” outside the Shanhaiguan pass for Zhang Xueliangs Northeastern army. Japanese sources indicate that Zhang Xueliang began covertly instructing local governments in Manchuria to comply with and pay taxes to Jinzhou. He also dispatched spies to Japanese-occupied territories and was conspiring to assassinate Japanese officials and those opposed to Chiang Kai-shek. Obviously Jinzhou had to be seized to control Liaoning and thus all of Manchuria. The Japanese first tried to bully Jinzhou into submission by bombing it. On October 8th, Ishiwara commanded five captured Chinese aircraft from the 10th Independent Air Squadron, flying from Mukden to conduct a raid on Jinzhou, claiming it was merely a reconnaissance mission. They flew over Jinzhou at approximately 1:40 PM and dropped 75 bombs weighing 25 kg each, targeting the barracks of the 28th Division, government buildings, and Zhang Xueliang's residence. Additionally, they took photographs of the Chinese defensive positions. The attack served two main purposes: to intimidate Zhang Xueliang and to send a message to Tokyo HQ. The bombing of Jinzhou caused an uproar in Tokyo and shocked the League of Nations, which had previously been indifferent to the situation. Consequently, Tokyo HQ felt compelled to retroactively approve the Kwantung attacks while simultaneously demanding an end to further actions. Rumors began to circulate that Ishiwara and his associate Itagaki aimed to establish an independent Manchuria as a base for a coup d'état against the Japanese government, intending to initiate a Showa Restoration. On October 18th, War Minister Minami Jiro sent a telegram to the Kwantung Army, ordering them to halt offensives in Manchuria and dispatched Colonel Imamura Hitoshi to ensure Ishiwara and Itagaki ceased their reckless operations. However, when Hitoshi met with the two men at a restaurant in Mukden, they dismissed him. In reality, Ishiwara and Itagaki's plans were in jeopardy, but in early November, they found a pretext for action after Ma Zhanshan's forces damaged the Nenjiang railway bridge. This hostility provided them with justification to invade Heilongjiang alongside their allies, led by General Zhang Haipeng. Following the occupation of the north, a new opportunity arose in the southwest. The "first Tientsin incident" erupted on November 9th, initiated by Colonel Doihara Kenji with assistance from some Anti-Chiang Kai-shek Chinese. A small contingent launched an attack on the peace preservation corps in Tientsin. Doihara devised this plan with the intention of creating chaos to kidnap the former Manchu emperor Puyi, allowing the Kwantung army to later install him as the ruler of a new Manchurian state. Although Doihara sought reinforcements from Tokyo HQ, his request was denied, prompting him to turn to the Kwantung army for support. They agreed to coordinate an attack on Tientsin but insisted that a pretext be established first. To execute this plan, they would need to capture Jinzhou initially. A second Tientsin incident occurred on November 26th, when Chinese soldiers attacked the Japanese barracks in Tientsin at 8:20 PM, marking another false flag operation orchestrated by Doihara. Upon hearing the news, General Honjo Shigeru chose to support the Tientsin army, which they believed was in peril. The 4th Mixed Brigade and the 2nd Infantry Battalion of the 2nd Division, comprising 10,000 troops, advanced toward 13 armored vehicles stationed along the Peiping-Mukden railway. The Kwantung Army also requested assistance from the Korean Army, and Commander Hayashi organized a mixed brigade to cross the border. Of course in order to provide assistance at Tientsin meant heading through the Shanhaiguan pass and this meant going through Jinzhou. Tokyo General HQ was yet again thrown into consternation by the latest aggravation of the Manchurian crisis. Incensed by the Kwantung Army's “lack of sincerity in submitting to the discipline of Tokyo”. The force got within 30km of Jinzhou when War Minister General Jiro Minami ordered them to immediately withdraw to a line east of the Liao river. Ironically what actually made the Kwantung Army comply was not so much Tokyo's authority but rather the refusal or foot dragging of the Korea Army, who sent a message that they were unwilling to attack Jinzhou. The Kwantung army continued on getting into some skirmishes with Chinese defenders around the Taling River and Takushan as Tokyo HQ sent countless furious messages demanding they withdraw from the Jinzhou area and by the 28th they finally did. Facing the real possibility that the Jinzhou operation might devolve into a fiasco without reinforcements, Ishiwara relented, remarking at the time “Tokyo has collapsed before Jinzhou”. There was another factor at play as well. Some have speculated Ishiwara tossed his hand on the field initiative because he was playing for time, expecting the Japanese government to fall and the substitution of a new team at central army HQ, one perhaps more compliant to the aggressive Kwantung Army.    While the Japanese forces pulled back into the SMR zone, Prime Minister Wakatsuki Reijiro began negotiations with Chiang Kai-Shek's Nanjing government, through the League of Nations, suggesting the Jinzhou area be declared a neutral area. The Chinese initially refused, and while the Kwantung Army declared they would not attack, they still sent aircraft to circle Jinzhou. The Chinese, British, American, and French governments were willing to withdraw their troops from Jinzhou to Shanhaiguan if the Manchurian incident was resolved and Japan committed to not infringing upon the area.    Consequently, Tokyo's headquarters supported this approach and instructed the Kwantung Army to withdraw. Although Zhang Xueliang had assured that his forces would leave Jinzhou by December 7th, this did not occur. As a result, the Japanese began discussions to establish Jinzhou as a neutral zone. The Kwantung army intercepted two Chinese telegrams indicating Zhang Xueliang was strengthening the defenses at Jinzhou and that Nanjing was requesting he not pull his men out. The telegrams were sent to Tokyo HQ who agreed the Chinese were acting in a treacherous manner. The Japanese ambassador then told US Secretary Henry Stimson  “it would be very difficult to withhold the army from advancing again.” Stimson replied “ such actions would convince the American public that Japan's excuse for her incursions, namely that she was combating bandit attacks, was a ruse to destroy the last fragment of Chinese authority in Manchuria. It would be extremely difficult to ask China to withdraw her army from her own territory.” Thus began the Jinzhou Crisis.   On the same day the Japanese ambassador was meeting Stimson in Washington, the Nationalist minister of finance, T.V Soong sent a telegram to Zhang Xueliang advising “any Japanese attack on Jinzhou should be offered utmost resistance.” Also the American Minister in China, Nelson Johnson publicly expressed the view that Zhang Xueliang would resist at Jinzhou if attacked “if only to reassure the students and public in general, some of whom clamor for military action, despite the attitude of his old generals of the Fengtian clique who desire his resignation to enable them to sell out to the Japanese”.   It had become clear to all observers that the Japanese were intent on capturing Jinzhou, whether they were justified to do so or not. Their tactics of intimidation became even bolder as they began dropping air torpedoes on disused sections of railway track on December 10th, disrupting traffic along the Beiping-Shenyang rail route and hinting that the nearby populated areas might be next. Ishiwara's hopes came true on December 13th, whence Prime Minister Wakatsuki resigned on December 11th, having failed to control the Kwantung Army. A new cabinet was formed under Prime Minister Tsuyoshi Inukai, whom resumed negotiations with Nanjing, but then on December 15th, Chiang Kai-Shek resigned as chairman of the Nanjing government, leading Sun Ke to lead a weak interim government. Preoccupied with its own survival, the Nanjing government had no time to deal with the Jinzhou crisis.   Meanwhile War Minister Minami and Chief of staff Kanaya who had tried to moderate the Kwantung Army's aggressive initiatives had been replaced by Araki Sadao, a significantly more aggressive leader who happened to be the leading figure of the Kodoha faction. His counterpart was Prince Kan'in. With these new appointments, the atmosphere in Tokyo general HQ had changed dramatically. The new team elected to change the framing of the situation, they were not performing offensives against Chinese forces, but rather “suppressing bandits”. On December 15th, Tokyo HQ telegraphed Mukden instructing the Kwantung Army to “synchronize an assault on Jinzhou with an attack upon bandits”. Tokyo HQ even agreed to send some reinforcements from Korea and Japan. The 20th IJA division, the 38th mixed brigade of the 19th division crossed the border from Korea and the 8th mixed brigade, 10th division came over from Japan. With this the Kwantung army had been bolstered to around 60,450men.    On December 17th, the Japanese launched attacks on what they referred to as "soldier bandits" in Fak'u and Ch'angtuhsien, which was actually a precursor to their assault on Jinzhou. The following day, December 18th, Japanese aircraft bombed Daonglio, resulting in the deaths of three Chinese civilians and causing widespread panic in the city. The Japanese actions were all the more effective when concentrated with the absolute paralysis that had gripped China. Sun Ke was too preoccupied with the survival of his own government and had neither the time nor resources to spare for Manchuria. In addition, Stimson's strong words in private to the Japanese ambassador belied the State Department's public attitude toward interference in the conflict. On December 21st Hawkling Yen, the Chinese charge in Washington met with Stanley Hornback, the chief of the department of Far Eastern Affairs. Yen told Hornback that a Japanese attack on Jinzhou was imminent and asked the US to “protest in anticipate of it”. Hornbeck refused, stating the State Department was “already publicly on record with regard to the matter”. No other Western power was ready to advocate any strong measures against the Japanese either.   On the 22nd, the Japanese HQ at Shenyang announced they would soon begin an anti-bandit advance west of the Liao River and would remove any who interfered with said operation. They also added that if any Chinese forces at Jinzhou withdrew they would be left unmolested. By December 26th, all preparations for the assault on Jinzhou were finalized. On December 28th, Honjo initiated an "anti-bandit" campaign west of the Liao River. While Honjo publicly claimed they were merely "clearing the country of bandits,”. As the Japanese forces and their collaborationist allies spread across the South Manchurian railway area to eliminate remaining pockets of resistance, the 12th Division, led by Lt. General Jiro Tamon advanced from Mukden toward Jinzhou, supported by numerous bomber squadrons. Japanese intelligence estimated that Zhang Xueliang had 84,000 troops defending the city, along with 58 artillery pieces and two distinct defensive lines. The first line, located 20 miles north of Jinzhou, consisted of trenches designed to impede the Japanese advance at the Taling River Bridge on the Peiping-Mukden Railway. The second line was a series of earthworks and fortifications completely surrounding Jinzhou. The temperature was -30 degrees, and the Imperial Japanese Army troops were dressed in white winter camouflage uniforms. IJA reconnaissance aircraft reported approximately 3,000 Honghuzi were waiting to ambush them in Panshan County. Tamon's forces quickly overcame the alleged Honghuzi in a series of small skirmishes and continued their march toward Goubangzi, 50 km north of Jinzhou. It should be noted, many question whether the Honghuzi were real or simply local Chinese the Japanese coerced into action to justify their advance. By December 31, the Japanese vanguard had reached within 15 km of Jinzhou, along the banks of the Talin River. Tamon paused to allow the rest of the 2nd Division to catch up. Subsequently, Tamon's troops began setting up an intricate system of microphones to broadcast the sounds of the impending battle to Tokyo. This tactic appeared to be an attempt to demoralize the defenders, which proved effective as Zhang Xueliang's forces began to withdraw. On December 30, Zhang Xueliang had issued the order to retreat from Jinzhou. Two days later, the American Minister in China, Nelson Johnson, reported the following scene: “Jinzhou Railway station resembles beehive, every possible car being pressed into service and loaded with troops, animals, baggage, to last inch space.” The last Chinese troop train departed Jingzhou at 11 am on January 1st carrying away the final remnants of Zhang Xueliang's authority in Manchuria. The assault on Jinzhou occurred at a particularly inopportune moment for China. Chiang Kai-shek was temporarily out of office, lacking the full support of the Nanjing government and many generals. It is likely that Chiang Kai-shek understood that Zhang Xueliang's forces in Jinzhou would be significantly outmatched and could be annihilated. His priority was to prevent the situation from escalating into an official war, allowing him to strengthen China's military capabilities for a counteroffensive. Following the fall of Jinzhou, the northern China army retreated south of the Great Wall into Hebei Province. The Japanese then occupied Shanhaiguan, securing complete control over southern Manchuria. Despite the fall of Jinzhou there was still one last holdout in Manchuria. After Ma Zhanshan was driven out of Qiqihar by the Japanese, he led his troops northeast to establish a new HQ in Hailun where he was still technically ruling Heilongjiang province. Ma Zhanshan had gained international recognition as a resistance hero following his ill-fated battle at Qiqihar. The Kwantung Army took note of his fame and adjusted their strategies accordingly. Komai Tokuzo, the head of the Kwantung Board of Control, suggested that bringing Ma Zhanshan into their ranks would provide a significant propaganda advantage. To persuade him to negotiate with the Kwantung Army, they sent a local factory owner, Han Yunje. On December 7th, Colonel Itagaki Seishiro met with Ma Zhanshan in Hailun. Itagaki expressed that the Japanese aimed for two objectives: peace in East Asia and full cooperation between the Chinese and Japanese. He also mentioned that the officers of the Kwantung Army were impressed by Ma's remarkable bravery and were willing to grant him military command over Heilongjiang, provided they reached an agreement. In response, Ma Zhanshan stated that his forces had acted solely in self-defense and that he was bound by the orders of the Nanjing government. Itagaki then suggested Ma Zhanshan might be appointed military commander of the province under the provincial governor in Qiqihar, Zhang Jinghui. To this Ma Zhanshan replied “as Hailun is not very far from Harbin, he could consult with General Zhang Jinghui over the telephone or pay a call on the latter in person, and that a second trip to Hailun by the Japanese representative would not be necessary.” Despite Ma's position, Itagaki felt satisfied with the meeting, believing that Ma Zhanshan might align with them. However, he was constrained by anti-Japanese colleagues like his chief of staff Xie Ke and battalion commander Tang Fengjia. The situation shifted significantly for Ma Zhanshan when Zhang Xueliang withdrew his forces from Jinzhou. On December 7th, Itagaki and Ma met once more, during which Ma expressed his desire to serve as both the military leader and governor of Heilongjiang. Unbeknownst to the Japanese, Ma Zhanshan was secretly in discussions with another resistance leader, General Ding Chao. When Ma Zhanshan initiated his resistance against the Japanese, Ding Chao decided to take similar action in the northern city of Harbin. Harbin serves as the gateway to Northeast China and is the political, economic, and cultural hub of North Manchuria. It functions not only as the center of the Sino-Soviet co-managed Middle East Railway but also as an international marketplace where Chinese and foreigners coexist. The city houses the Special Administrative Region of the Three Eastern Provinces (with Daoli under this region and Daowai belonging to Jilin Province). Following the Mukden Incident, the Japanese army considered attacking Harbin; however, concerns about potential Soviet interference led to the plan being halted by Army Minister Minami Jiro. Harbin had largely remained peaceful, and the Japanese maintained control by appointing the puppet General Xi Qia as the governor of Kirin province. Together with Li Du, Xing Zhangqing, Zhao Yi, and Feng Zhanhai, Ding Chao formed the Kirin self-defense army to thwart the takeover of Harbin and Kirin province. Ma Zhanshan supported Ding Chao, and both generals kept in touch with Zhang Xueliang and Chiang Kai-shek, who could only offer limited support. In November of the same year, the Jilin Provincial Anti-Japanese Government, chaired by Cheng Yun, was established in Bin County. Feng Zhanhai, the head of the guard regiment at the Northeast Frontier Defense Army's deputy commander-in-chief office in Jilin, refused to surrender to the Japanese forces. He rallied over 3,000 members of his regiment to resist the Japanese and rebel forces. They marched from Yongji County in Jilin Province to Shulan County, where they joined forces with the national salvation armies led by Gong Changhai and Yao Bingqian, which were based on green forest armed groups, to create the Jilin Anti-Japanese National Salvation Army, with Feng as the commander. On November 12, the Jilin Provincial Provisional Government was established in Bin County . Feng Zhanhai was appointed as the garrison commander and commander of the 1st Brigade. The units led by Gong and Yao were reorganized into cavalry brigades under Feng's command. This series of anti-Japanese actions significantly boosted the fighting spirit of the people in Jilin and Heilongjiang provinces. To launch an attack on Harbin, the Japanese Kwantung Army first needed to "punish" the anti-Japanese armed forces by force. To eliminate Feng's anti-Japanese forces, the Japanese puppet authorities dispatched Yu Shencheng, the commander of the Jilin "bandit suppression" unit, to lead the puppet army in an offensive aimed at seizing Harbin as a base to control the Jilin and Heilongjiang provinces. Feng Zhanhai's troops strategically abandoned Shulan City to lure the enemy deeper into the area. The puppet army fell into a trap and launched a major assault on Yao Bingqian's brigade stationed in Shuiquliu, which fiercely resisted the attack. On the same day, Gong Changhai's brigade maneuvered around to the rear of the puppet army for a surprise attack, while Yao's brigade counterattacked from the front. The puppet army's Ma Xilin brigade retreated, unable to be halted by the Japanese supervisory team. At this point, Feng Zhanhai led another brigade into the fray, pursuing Ma's brigade. After another seven hours of intense fighting, Shulan was retaken. In this battle, the garrison inflicted nearly 1,000 casualties on Japanese and puppet troops, captured hundreds, and saw many puppet soldiers defect. The battles of Shuiqu and Shulan were thus victorious. On the 16th, Yu Shencheng's puppet forces were defeated by the 25th Brigade of the Northeast Army in Yushu. Due to the precarious situation in Shulan, Feng Zhanhai had no choice but to abandon Shulan City and retreat his troops north of Wuchang. On the 19th, seeking urgently needed funds for his troops, Feng Zhanhai led a battalion from Acheng to Lalinkang, where they were surrounded by a significant number of Japanese and puppet troops. The following day, with the help of reinforcements, they managed to repel the Japanese and puppet forces. However, the troops suffered over 200 casualties and were compelled to leave Lalinkang and return to Acheng. On the 25th, Feng and Li moved their forces to the eastern suburbs of Harbin, with the 22nd, 26th, and 28th Brigades announcing their support in succession.On the morning of the 26th, Feng and Li entered the city from four directions, forcibly disarming five police brigades and seizing more than 3,000 firearms along with a number of heavy weapons. They stationed the 26th and 28th Brigades and one regiment in the Shanghao area, while Feng Zhanhai's four brigades and two detachments were positioned in the Sankeshu and Nangang areas. The 22nd Brigade was assigned to Shuangchengbao, preparing to defend against a Japanese assault.  Meanwhile the Japanese were still trying to win over Ma Zhanshan. This prompted our old friend Doihara to ask Xi Qia to advance his new “Jilin Army” to Harbin and then to Hailun. However in their way was the Jilin Self-Defense force of General Ding Chao and General Li Du had deployed his forces between Xi Qia and Harbin. On the 24th, representatives from Li Du and Ding Chao participated in a meeting with Ma Zhanshan's officers, convincing them to attempt to retake Qiqihar and defend Harbin for the resistance. When Xiqia's "New Jilin Army" finally advanced to Shuangcheng on the 25th, Zhang Xueliang instructed Ma Zhanshan and Ding Chao to abandon negotiations and begin fighting on the morning of the 26th. Kenji Doihara ultimately failed to intimidate the Chinese further, as his ally Xicha's troops encountered stiff resistance from Ding Chao's troops. Later that afternoon, Japanese aircraft dropped leaflets over Harbin, openly demanding that the anti-Japanese forces withdraw from the city immediately. The Japanese Consulate in Harbin also issued a notice to various foreign consulates, stating that the Japanese army would enter Harbin at 3:00 PM on the 28th. As the New Jilin army advanced towards Shuangcheng, this signaled to the Chinese resistance fighters that an attack was imminent. Zhang Xueliang instructed Generals Ma Zhanshan and Ding Chao to halt negotiations and prepare to make a stand. By late January, the Kirin Self-Defense Corps had grown to 30,000 members, organized into six brigades. Ding Chao fortified defensive positions between General Xi Qia's advancing troops and Harbin. Xi Qia was caught off guard by the well-organized resistance forces, resulting in heavy losses for his army, which was unable to break through. In desperation, Xi Qia sought assistance from the Kwantung Army, but they needed a justification to intervene. Once again, Colonel Doihara Kenji orchestrated a false flag operation. He incited a riot in Harbin that resulted in the deaths of one Japanese individual and three Koreans. Using the pretext that Japanese citizens were in danger, the 2nd Division under Lt. General Jiro Tamon began its advance toward Harbin from Jinzhou on the 28th. However, severe winter weather delayed their transportation. To complicate matters further, the Soviets denied Japanese trains access to Harbin via their section of the Chinese Eastern Railway, citing a breach of neutrality. The entire Manchurian incident had escalated tensions between the USSR and Japan. When they invaded Heilongjiang, there were genuine concerns about potential Soviet intervention, especially with their presence in Harbin. However, at the last moment, the Soviets agreed to allow transit on January 30th. Back on the 26, 1932, Feng Zhanhai and Li Du, the commander of the Yilan garrison, entered Harbin. Early on the 27th, Yu Shencheng, the commander of the puppet Jilin "bandit suppression," ordered two brigades to attack the Shanghao, Sankeshu, and Nangang areas. Japanese aircraft bombed the Sankeshu and Nangang regions. The two brigades tasked with defending the area fought valiantly, resulting in intense combat. Soon after, Feng Zhanhai and his reserve team joined the fray, launching a political offensive alongside their fierce attacks. The puppet army struggled to hold its ground and retreated to Lalincang. The defending troops in Shanghao fought tenaciously, inflicting heavy casualties on both Japanese and puppet forces, shooting down one plane, and attempting to persuade puppet army commander Tian Desheng to lead a revolt. By evening, the puppet army had been driven back. On the morning of the 28th, the anti-Japanese forces advanced to the Jile Temple and Confucian Temple, capturing advantageous positions near Xinfatun with artillery support. The cavalry brigade flanked the puppet army and launched a vigorous assault, leading to the collapse and retreat of the puppet forces towards Acheng. Gong Changhai led the cavalry in pursuit for 15 kilometers, capturing a significant number of puppet troops. After two days of fierce fighting on the 27th and 28th, the initial invasion of Harbin by Japanese and puppet troops was successfully repelled. Due to the defeat of Yu Shencheng and other puppet forces, the Japanese Kwantung Army launched a direct assault on Harbin on the morning of the28th, under the pretext of "protecting overseas Chinese." They ordered Hasebe, commander of the 3rd Brigade of the Kwantung Army, to lead the 4th Regiment, an artillery battalion, and two tanks on a train from Changchun to Harbin for combat. On the29th, another combat order was issued: the 2nd Division was to assemble in Changchun and then be transported to Harbin by truck. Part of the 4th Mixed Brigade was also moved from Qiqihar to Anda and Zhaodong by truck to support the 2nd Division from the north of Harbin. The 1st, 3rd, 8th, and 9th Squadrons of the Kwantung Army Flying Team were tasked with covering the assembly, advance, and attack of the 2nd Division. Hasebe's 4th Regiment departed from Changchun by train, but due to extensive damage to the railway caused by the Northeast Army, their train was attacked by the Northeast Army at dawn on the 29th as it reached the Laoshaogou area on the south bank of the Songhua River. The Japanese forces quickly shifted to an offensive strategy and, despite ongoing resistance, managed to reach Shitouchengzi Village north of the Sancha River that night. On the night of January 29, Zhao Yi's brigade received word of the Japanese assault on Harbin and immediately prepared for battle. At dawn on January 30, Brigade Commander Zhao Yi led six battalions in a light advance, launching a surprise attack on Shilipu, where they decisively defeated the puppet army's Liu Baolin Brigade, capturing over 700 soldiers and seizing more than 600 weapons. They then returned to Shuangchengbao to prepare for the annihilation of the advancing Japanese forces. Around 8:00 PM, the 3rd Brigade of the Japanese Army, along with the Changgu Detachment and two military vehicles, arrived at Shuangcheng Station, intending to camp there and attack Harbin the following day. Zhao Yi's troops set up an ambush in the area. As the Japanese forces disembarked and assembled to plan their attack on Harbin, the ambushing troops took advantage of their unpreparedness, launching a surprise attack from three sides. They unleashed heavy firepower, forcing the enemy back onto the platform before engaging in close combat with bayonets and grenades. The Japanese were caught off guard and suffered significant casualties. The next day, the Japanese dispatched reinforcements from Changchun, supported by aircraft, artillery, and tanks, to assault Shuangchengbao. Brigade Zhao found himself trapped in the isolated city, suffering over 600 casualties, including the regiment commander, and was ultimately forced to abandon Shuangchengbao and retreat to Harbin. With Shuangcheng captured, Harbin was left vulnerable. The Self-Defense Army stationed the majority of its troops in the southern, southeastern, and southwestern regions of Harbin, including Guxiangyuetun, Bingyuan Street, Old Harbin City, and Lalatun. On the same day, several commanders convened: Li Du, the garrison commander of Yilan and leader of the 24th Brigade; Feng Zhanhai, commander of the Jilin Provincial Security Army; Xing Zhanqing, commander of the 26th Brigade; Zhao Yi, commander of the 22nd Brigade; Ding Chao, acting commander of the Railway Protection Army and leader of the 28th Brigade; and Wang Zhiyou, director of the Jilin Police Department. They agreed to establish the Jilin Provincial Self-Defense Army, appointing Li Du as commander, Feng Zhanhai as deputy commander, and Wang Zhiyou as the commander-in-chief of the front line. They decided to utilize the 22nd, 24th, 26th, and 28th Brigades for the defense of Harbin, while Feng Zhanhai would lead the 1st Brigade and other units in a flanking maneuver against Jilin and Changchun to thwart the Japanese advance. On February 3, 1932, various units of the Japanese 2nd Division arrived in the Weitanggou River area. Under the command of Duomen, the division initiated an assault on the Self-Defense Army's outposts located outside Harbin. The 3rd Infantry Brigade of the 2nd Division, alongside Yu Shencheng, the commander of the pseudo-Jilin "bandit suppression" forces, led an attack with five brigades as the right flank against Chinese defenders in the Qinjiagang, Nangang, and Shanghao regions. Meanwhile, the 15th Infantry Brigade of the Japanese Army formed the left flank, targeting Guxiangtun via Balibao along the Songhua River. Following the conflict, all outposts of the Self-Defense Army were lost, forcing them to retreat to their primary positions. On the morning of February 4th, the Japanese forces launched a full-scale attack, engaging the Self-Defense Army in battle. By afternoon, the Japanese had positioned themselves on both sides of the railway, south of Guxiang Yuetun, Yongfatun, and Yangmajia. The 3rd Brigade was stationed east of the railway, while the 15th Brigade took position to the west. After a preparatory artillery barrage, the Japanese forces commenced their assault. The Jilin Self-Defense Army defended tenaciously, utilizing fortifications and village structures, and concentrated their artillery fire on the advancing enemy, inflicting significant casualties.   Despite their efforts, the Japanese attack was initially repelled, prompting them to adopt a defensive stance. By 16:00, the area from Yangmajia to Yongfatun had fallen to the Japanese. The Self-Defense Army continued to resist fiercely, but the Japanese intensified their assaults. The left flank launched a vigorous attack on Guxiangtun. The 28th Brigade of the Self-Defense Army, defending this area, utilized civilian structures and walls for their defense. However, brigade commander Wang Ruihua fled under pressure, leading to a loss of command and forcing the troops to abandon their positions and retreat into the city. Simultaneously, the Japanese right flank aggressively targeted the defense of the 26th Brigade of the Self-Defense Army. Despite the desperate efforts of brigade commander Xing Zhanqing and his troops, they were ultimately compelled to retreat to the river dam at Shiliudao Street due to inferior equipment. Around this time, the western and southern defense lines under Wang Zhiyou's command began to fall one after another. In this critical situation, Commander-in-Chief Li Du personally went to the front lines to organize the troops and establish a third defensive line on the city's edge. They fought until nightfall, successfully halting the Japanese advance. At dawn on February 5th the Self-Defense Army initiated a counteroffensive. The artillery first conducted preparatory fire, targeting the positions of the Japanese 3rd Brigade located east of the railway. Following this, the infantry launched their attack. The Japanese troops on the front lines found themselves in a precarious situation. In response, Jiro Tamon, the commander of the 2nd Division, urgently ordered artillery to intercept the Self-Defense Army's counterattack and deployed the tank and reserve units to assist. Four squadrons from the air force took off from a temporary forward airfield in Shuangcheng, alternating between bombing and strafing to support the ground troops. The battle was intensely fierce, resulting in heavy casualties on both sides. Lacking air support and facing significant threats from Japanese aircraft, the Self-Defense Army retreated to the area east of Harbin by the afternoon of the 5th. The Japanese forces then entered Harbin, leading to its immediate capture. On the 6th, the remaining self-defense forces learned of Harbin's fall and decided to abandon their original plan for a surprise attack against the Japanese army. Instead, they returned to Binxian and Fangzheng. During their retreat, they gathered some stragglers who had fled from Harbin and proceeded to Fangzheng County to regroup with Li Du. General Ding Chao's forces were compelled to retreat northeast along the Sungari River, while Japanese aircraft attacked them from above. After a grueling 17-hour battle, Ding Chao's army ultimately faced defeat. Following this loss, Ma Zhanshan made the decision to defect. On February 16, General Honjo held a conference for the Northeast Political Affairs Committee in Mukden, attended by senior Chinese officials of the new regime, including Zhang Jinghui, Ma Zhanshan, Zang Shiyi, Xi Qia, and others. The conference aimed to assign delegates to roles in the soon-to-be-established “Manchukuo.” On February 14, Ma Zhanshan was appointed governor of Heilongjiang province and received gold worth one million dollars. On February 27th, Ding Chao proposed a ceasefire, marking the official end of Chinese resistance in Manchuria. On March 1st, Puyi would be installed as the ruler of the new state of Manchukuo. I would like to take this time to remind you all that this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Please go subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry after that, give my personal channel a look over at The Pacific War Channel at Youtube, it would mean a lot to me. With the fall of Jinzhou, Zhang Xueliang had effectively been kicked out of Manchuria. With the loss of Harbin, came the loss of any significant resistance to the Japanese invasion of Manchuria. Japan had conquered the northeast and now would enthrone the last Emperor of the Qing Dynasty forming the puppet state of Manchukuo. 

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com https://www.facebook.com/melissaparkspsychicMelissa's Shop: https://shop.spreadshirt.com/melissaparkspsychiccreationsLeave a Review for Melissa on Google: https://maps.app.goo.gl/sXm86FLU9cnDcRVD6Melissa's Venmo: https://account.venmo.com/u/Melissa-Parks-37Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com https://www.facebook.com/melissaparkspsychicMelissa's Shop: https://shop.spreadshirt.com/melissaparkspsychiccreationsLeave a Review for Melissa on Google: https://maps.app.goo.gl/sXm86FLU9cnDcRVD6Melissa's Venmo: https://account.venmo.com/u/Melissa-Parks-37Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

In this episode, we're sharing a feng shui qi forecast for the month of March 2025! First, we discuss what's going on in nature and what you can expect energetically this month, and then Laura shares a tarot reading for the Holistic Spaces Podcast listener community. We also share a feng shui suggestion to make the most of this month's energy. We cover:-Key dates to look out for this month in the moon's cycle and the solar term from the Chinese calendar-What's in store energetically for March 2025-The Chinese zodiac animal connected to March and what that means for you-“Spring Equinox”, celebrating when day and night are equal, after which the sun grows stronger and the days lengthen-The qi of March 2025-Auspicious days of the month, and which days you might want to exercise caution in March 2025And much more!Mentioned in this episode:-Our free Bagua ekitThanks so much for listening to the Holistic Spaces Podcast brought to you by Mindful Design Feng Shui School!-Sign up for our newsletter for exclusive complimentary special workshops and offers for our newsletter subscribers ONLY! -Make sure you're following us on Instagram for feng shui tips and live Q&A's.-Learn about our courses and certification on our website at: Mindful Design School.-Check out our older episodes on our Holistic Spaces Podcast archive.MORE QUESTIONSHire one of our Mindful design school Grads for a 1-1 consultation. We know so many personal questions come up. That's why you need a 1-1! Laura and Anjie offer all these freebies, but if you want to learn more it's time to ask a professional. learn more HERENEW EPISODES OF THE HOLISTIC SPACES PODCAST BY MINDFUL DESIGN ARE AVAILABLE EVERY MONDAY.Time stamps for the episode:-[01:16] Introduction-[01:41] Solar terms for March 2025-[04:25] The full moon on March 14th-[05:15] The twelve animals of the Chinese Zodiac-[05:51] Which days to exercise caution in March 2025-[07:05] The qi of March 2025-[08:00] A tarot reading for the month-[14:09] Feng shui to support you this monthORDER OUR NEW BOOK HERE

After years of professional work as consultants and teachers, we've seen just about every use and misuse of feng shui principles imaginable. From the over the top paint jobs to confusion or misinterpretation of the bagua, some missteps are more common than others. For episode 317, we are taking a look at some of the most common feng shui faux pas that we've encountered.We cover:-Why it's best to start simple, avoiding many, sometimes conflicting sources of information on feng shui-How to avoid confusion or feeling overwhelmed when applying the bagua-Adopting more balanced approach to color when it comes to paint-How to stop worrying about “bad” feng shuiAnd much more!Mentioned in this episode:Our free Bagua ekitThanks so much for listening to the Holistic Spaces Podcast brought to you by Mindful Design Feng Shui School!-Sign up for our newsletter for exclusive complimentary special workshops and offers for our newsletter subscribers ONLY! -Make sure you're following us on Instagram for feng shui tips and live Q&A's.-Learn about our courses and certification on our website at: Mindful Design School.-Check out our older episodes on our Holistic Spaces Podcast archive.MORE QUESTIONSHire one of our Mindful design school Grads for a 1-1 consultation. We know so many personal questions come up. That's why you need a 1-1! Laura and Anjie offer all these freebies, but if you want to learn more it's time to ask a professional. learn more HERENEW EPISODES OF THE HOLISTIC SPACES PODCAST BY MINDFUL DESIGN ARE AVAILABLE EVERY MONDAY.Time stamps for the episode:-[[00:50] Introduction-[01:28] Mixing and matching different feng shui suggestions from the internet or books-[03:00] Confusion with applying the Feng shui Bagua-[05:12] Painting rooms a color you hate-[08:05]Tossing cactus plants-[10:15] “Bad Feng Shui”-[12:54] Dried or artificial flowers-[15:08] General guidelines for avoiding feng shui faux pasORDER OUR NEW BOOK HERE

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com https://www.facebook.com/melissaparkspsychichttps://lbri.com/iammelissaparksMelissa's Shop: https://shop.spreadshirt.com/melissaparkspsychiccreationsLeave a Review for Melissa on Google: https://maps.app.goo.gl/sXm86FLU9cnDcRVD6Melissa's Venmo: https://account.venmo.com/u/Melissa-Parks-37Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com https://www.facebook.com/melissaparkspsychichttps://lbri.com/iammelissaparksMelissa's Shop: https://shop.spreadshirt.com/melissaparkspsychiccreationsLeave a Review for Melissa on Google: https://maps.app.goo.gl/sXm86FLU9cnDcRVD6Melissa's Venmo: https://account.venmo.com/u/Melissa-Parks-37Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Goldylocks Productions presents Joyful Findings with Melissa ParksMelissa Parks is an Earth Angel, a talented Psychic Trance Medium, Angelic Guided Healer, Reiki Master, Spiritual Advisor and Spiritual Teacher. As a child she was able to see and communicate with the Spirit World but was shut down and told to ignore her gifts. Most of her life was filled with hurt, anger, and pain. It wasn't until a “voice” told her she must forgive her childhood abuser that her heart had truly opened, and her Spiritual Journey began.Once she embraced her True Self and her connection to God's Divine Beings, she understood her life's plan. She now spreads Love and Light, giving Guidance and Healing to all who seek it. Whether in a reading or healing session she opens to Past Loved Ones, Angels, Guides, and many Multi-Dimension Healers to bring forth powerful messages of Guidance and Healing.http://www.iammelissaparks.com Melissa's Sponsor: Marcia Morse with Feng Shui My SpaceFeng shui literally translates from Chinese as "wind" (feng) and water ("shui"). It's the art of arranging buildings, objects, space, and life to achieve harmony and balance. The philosophy of feng shui is the practice of arranging the pieces in living spaces in order to create balance with the natural world. The goal is to harness energy forces and establish harmony between an individual and their environment. Contact Feng Shui Specialist, Marcia Morse, to assist you in bringing in more Harmony and Peace into your home, property, or business space! Marcia is also a Realtor and can assist you in finding your New Home in the Sarasota, Florida area.https://www.fengshuimyspace.comhttp://www.sarasotasunset.com Become a member at https://plus.acast.com/s/goldylocks-productions. Hosted on Acast. See acast.com/privacy for more information.

Fluent Fiction - Mandarin Chinese: Mei's Journey: Embracing Tradition at the Great Wall Find the full episode transcript, vocabulary words, and more:fluentfiction.com/zh/episode/2025-01-29-23-34-00-zh Story Transcript:Zh: 梅和她的家人来到长城上过春节。En: Mei and her family came to the Great Wall of China to celebrate the Spring Festival.Zh: 天很冷，雪覆盖了大地，但他们的心是暖的。En: The weather was very cold, and snow covered the ground, but their hearts were warm.Zh: 红灯笼高挂，彩带随风飘扬。En: Red lanterns hung high, and colored ribbons fluttered in the wind.Zh: 长城雄伟壮观，与节日的喜庆氛围完美融合。En: The majestic and spectacular Great Wall perfectly blended with the festive atmosphere.Zh: 梅站在风中，感觉到一种古老而神秘的力量。En: Mei stood in the wind, feeling an ancient and mysterious power.Zh: 她的祖父风坐在一旁，脸上露出慈祥的微笑。En: Her grandfather Feng sat nearby, with a kind smile on his face.Zh: 他是个睿智而传统的人，相信家庭团结。En: He was a wise and traditional person, believing in family unity.Zh: 他轻轻拍了拍梅的肩膀，“梅，今年你愿意和我们一起参与家族的传统吗？En: He gently patted Mei's shoulder, "Mei, are you willing to join us in participating in the family's traditions this year?"Zh: ”梅一直想更深入地了解自己的家族历史和文化。En: Mei had always wanted to delve deeper into her family's history and culture.Zh: 她点了点头，但心里仍感到一些疑惑。En: She nodded, yet still felt some confusion.Zh: 她的表弟金走过来，手里拿着手机，“梅，来看看这个新科技应用，它真酷。En: Her cousin Jin came over, holding a smartphone, "Mei, come check out this new tech app, it's really cool."Zh: ”金一直专注于他的事业，总是被现代科技所吸引，这些让梅有些分心。En: Jin had always been focused on his career and was attracted to modern technology, which distracted Mei a bit.Zh: 但端起手机，她发现自己并不感兴趣。En: But picking up the phone, she found she wasn't interested.Zh: 她知道自己的目标是理解家庭，与其文化建立联系。En: She knew her goal was to understand her family and connect with its culture.Zh: 春节的晚上，家人在长城上留下了笑声与歌声。En: On the night of the Spring Festival, the family left laughter and songs on the Great Wall.Zh: 风爷爷把大家聚集在一起，点燃了鞭炮，传统的习俗把所有人团结在温暖的氛围中。En: Grandpa Feng gathered everyone together and lit firecrackers.Zh: “梅，今年我的故事特别为你准备。En: The traditional customs united everyone in a warm atmosphere.Zh: ”风爷爷说。En: "Mei, my story this year is specially prepared for you," Grandpa Feng said.Zh: 他开始讲述家族的历史，长城如何守护着中国的国土，也见证了他们家族的繁衍生息。En: He began to tell the family's history, about how the Great Wall had protected China's territory and witnessed their family's growth and life.Zh: 梅仔细聆听，过去的故事渐渐将她环绕。En: Mei listened carefully as the stories of the past gradually enveloped her.Zh: 她不再想去查手机的消息，心中已有了答案。En: She no longer wanted to check messages on her phone; she already had the answer in her heart.Zh: 此刻，她明白自己是家族历史的一部分，不仅是个体。En: At that moment, she understood she was part of the family history, not just an individual.Zh: 接下来的几天，梅和家人一起打扫、布置、包饺子。En: In the following days, Mei and her family cleaned, decorated, and made dumplings together.Zh: 她参与其中，感受到了真正的快乐。En: She participated and felt true happiness.Zh: 在这些简单的活动中，她发现自己和家人更亲密了。En: In these simple activities, she found herself closer to her family.Zh: 春节的最后一天，梅又站在长城上，看着远方。En: On the last day of the Spring Festival, Mei stood on the Great Wall again, looking into the distance.Zh: 她心中充满感激，接受着传统与现代的平衡。En: Her heart was full of gratitude, accepting the balance between tradition and modernity.Zh: 她笑着对风爷爷说，“谢谢您，告诉我这些。En: Smiling at Grandpa Feng, she said, “Thank you for telling me these stories.Zh: 我今天感觉自己的根在这里。En: Today, I feel my roots are here.” The story ended in warm laughter.Zh: ”故事在暖暖的欢笑中结束。En: Mei found her pace in modern life while embracing her family's traditions.Zh: 梅在现代生活中找到自己的步伐，也拥抱着家族的传统，两个世界的结合让她更加完整。En: The combination of both worlds made her more complete.Zh: 长城静静地矗立在那里，见证着这一刻的美好。En: The Great Wall stood there quietly, witnessing the beauty of this moment. Vocabulary Words:celebrate: 过majestic: 雄伟spectacular: 壮观ancient: 古老mysterious: 神秘wisdom: 睿智tradition: 传统participate: 参与delve: 深入confusion: 疑惑technology: 科技distracted: 分心connect: 建立联系laughter: 笑声customs: 习俗united: 团结envelop: 环绕protect: 守护witness: 见证gratitude: 感激balance: 平衡root: 根complete: 完整decorate: 布置dumplings: 饺子traditional: 传统的individual: 个体spiral: 繁衍territory: 国土gather: 聚集

In The M&A Failure Trap: Why Most Mergers and Acquisitions Fail and How the Few Succeed, Baruch Lev and Feng Gu provide a wealth of evidence on the success and failure factors of acquisitions.Lev, professor emeritus of Accounting and Finance at NYU's Stern School of Business and Gu, professor of Accounting and Law at the State University of New York, have analyzed more than 40,000 acquisitions over the past four decades. This has not only allowed them to understand the reasons why 75% of deals fail but also to develop a scorecard that can help decision-makers assess the likelihood of acquisition success ex ante.In their conversation with Martin Reeves, chairman of the BCG Henderson Institute, Lev and Gu discuss how to measure acquisition success, how to curb overconfidence on the side of the acquirer, and key lessons for CEOs seeking inorganic growth.Key topics discussed:[02:45] How mergers and acquisitions have changed[05:00] Judging the success or failure of acquisitions[08:16] Drivers of acquisition failure[14:41] Patterns of successful acquisitions[17:27] Overconfidence and its causes[19:51] Managerial implications

Which bets stand out for Monday's College Football National Championship Game between Ohio State and Notre Dame? The Power Rank's Dr. Ed Feng joins Jim Sannes to preview the game, discussing his read on the traditional markets and which player props he likes. Later, Feng previews the NFL's Divisional Round, outlining where he sees betting value there.

For part two of our overview of this year's energy forecast we are covering the remaining six animals of the Chinese zodiac for Year of the Wood Snake, as well as what you can expect based on your birth year animal's relationship to the Snake.We cover:-The Snake as a symbol of transformation and healing-The softness of Yin in a Wood year-3 Feng shui tips for every one to do in the Year of the Wood Snake-Why those born in the year of the Horse may want to take a page from the Snake's book and slow down-The soft, earthy nature of the Ram and how it will be supported this year-The year of the Snake is auspicious for those born in the year of the Monkey-The natural harmony that occurs between the Rooster and the Snake-The loyalty of the dog being a good match for the Snake-Why those born in the year of the Pig may have a challenging year aheadMentioned in this episode:-Welcoming the Year of the Snake for Each Zodiac Animal, Part 1-2025 Feng Shui Amulet for Protection & Luck-What to do with your feng shui amulets from years pastThanks so much for listening to the Holistic Spaces Podcast brought to you by Mindful Design Feng Shui School!-Sign up for our newsletter for exclusive complimentary special workshops and offers for our newsletter subscribers ONLY! -Make sure you're following us on Instagram for feng shui tips and live Q&A's.-Learn about our courses and certification on our website at: Mindful Design School.-Check out our older episodes on our Holistic Spaces Podcast archive.MORE QUESTIONSHire one of our Mindful design school Grads for a 1-1 consultation. We know so many personal questions come up. That's why you need a 1-1! Laura and Anjie offer all these freebies, but if you want to learn more it's time to ask a professional. learn more HERENEW EPISODES OF THE HOLISTIC SPACES PODCAST BY MINDFUL DESIGN ARE AVAILABLE EVERY MONDAY.Time stamps for the episode:-[01:58] Three feng shui tips for everyone-[06:33] The meaning of yin wood-[12:02] The Horse-[13:25] The Ram-[15:23] The Monkey-[17:10] The Rooster-[19:08] The Dog-[20:15] The PigORDER OUR NEW BOOK HERE

In this episode, our host Lara Momesso interviews Yi-Fan Feng (馮一凡), the Deputy Chief Executive at Harmony Home Taiwan, to discuss the work that Harmony Home has done with some of the most marginalised people in Taiwan: people living with HIV/AIDS and undocumented residents and their children. In this chat, Lara and Yi-Fan explore how more than 40 years of activities by Harmony Home have contributed not only to help people living with HIV/AIDS and undocumented residents but also to change the way the Taiwanese government and society approached these groups. If you want to know more about Harmony Home, what they do and how to support it, follow this link: www.twhhf.org If you want to watch the documentary movie mentioned in the interview, Mimi's Utopia, follow this link: www.youtube.com/watch?v=qjVfVEl58WU Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

In this episode, our host Lara Momesso interviews Yi-Fan Feng (馮一凡), the Deputy Chief Executive at Harmony Home Taiwan, to discuss the work that Harmony Home has done with some of the most marginalised people in Taiwan: people living with HIV/AIDS and undocumented residents and their children. In this chat, Lara and Yi-Fan explore how more than 40 years of activities by Harmony Home have contributed not only to help people living with HIV/AIDS and undocumented residents but also to change the way the Taiwanese government and society approached these groups. If you want to know more about Harmony Home, what they do and how to support it, follow this link: www.twhhf.org If you want to watch the documentary movie mentioned in the interview, Mimi's Utopia, follow this link: www.youtube.com/watch?v=qjVfVEl58WU Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/east-asian-studies

Happy new year! As we kick off 2025, the year of the Wood Snake, we are once again sharing afeng shui qi forecast for the month of January 2025! First, we discuss what's going on in nature and what you can expect energetically this month, and then Laura shares a tarot reading for the Holistic Spaces Podcast listener community. We also share how you can make the most of this month's energy in your home through feng shui.Discussed in this episode:-Key dates to look out for this month in the moon's cycle and the Chinese solar term calendar-What to expect this month based on your Chinese zodiac animal-Why this is the right time to find emotional support and heed the call of what fills your heart-How this first month of 2025 might be the perfect time to take stock of all of our blessings and show appreciation for them-Why now is the time to embrace your inner empress!-Our feng shui suggestions to make the most of this month's energyand much more!Thanks so much for listening to the Holistic Spaces Podcast brought to you by Mindful Design Feng Shui School!-Sign up for our newsletter for exclusive complimentary special workshops and offers for our newsletter subscribers ONLY! -Make sure you're following us on Instagram for feng shui tips and live Q&A's.-Learn about our courses and certification on our website at: Mindful Design School.-Check out our older episodes on our Holistic Spaces Podcast archive.MORE QUESTIONSHire one of our Mindful design school Grads for a 1-1 consultation. We know so many personal questions come up. That's why you need a 1-1! Laura and Anjie offer all these freebies, but if you want to learn more it's time to ask a professional. learn more HERENEW EPISODES OF THE HOLISTIC SPACES PODCAST BY MINDFUL DESIGN ARE AVAILABLE EVERY MONDAY.Mindful Design School's Annual Energy Reset PackageFind harmony and ease with feng shui in 2025 Year of the Wood Snakeis now OPEN FOR ENROLLMENT!Click here to sign upTime stamps for the episode:-[07:38] For the year of Wood Snake: Wild Abundance-[02:55] Introduction-[04:04] Overview for January 2025-[05:41] Solar terms for January 2025-[09:04] Auspicious dates for January 2025-[13:08] The qi of January 2025-[14:35] A tarot reading for the Holistic Spaces listener community-[21:56] Feng shui advice for the monthORDER OUR NEW BOOK HERE

Send us a textCan the words we speak and the intentions we hold truly shape our physical reality? Journey with means we explore this fascinating possibility. We'll revisit the controversial experiments of Masaru Emoto, who posited that words could influence the crystalline structure of water. Though often dismissed as pseudoscience, a new study by Feng et al. (2023), revitalizes this idea and examines if written words can influence biological systems. This research reveals that human embryonic kidney cells exposed to positive words show significant improvements in health markers. While this concept might echo Emoto's work, it opens a Pandora's box of questions about whether words act as energetic emitters affecting cellular structures. The possibility of language influencing biology through information fields or biofields may sound speculative, but it offers compelling directions for future research and leads us to consider the impact of positive self-talk on personal growth & health. The resonant effects of affirmations and the physiological responses they evoke may not be as "out there" as we once thought.takeawaysA new study suggests a link between words and cellular function.The implications of this research challenge traditional views Our thoughts and intentions may influence our physical health.This resurrects Masaru Emoto's water experiments The scientific community largely viewed Emoto's work as pseudoscience.Gerald Pollock's research introduces the concept of structured water.Structured water behaves differently around biological substances.Water can have a memory for substances it interacts with.While we don't know is these effects are real and what is causing them, it would fundamentally alter our understanding if this proved to be reproducibleChapters00:00Introduction to the Power of Thoughts04:45Gerald Pollock's Research on Water Structure6:50The Structure of Biological Water10:00How Water May Carry Information12:19The Feng et al. Study20:30Exploring Mechanisms: How Words Might Influence Biology27:40The Power of Positive Words and Self-Talk Looking for a Next Level Human Coach? Get on the waitlist and get access to the brand-new science of quantum metabolism and identity restructuring with Dr Jade and the team.http://nextlevelhuman.com/human-coaching Connect with Next Level HumanWebsite: www.nextlevelhuman.comsupport@nextlevelhuman.comConnect with Dr. Jade TetaWebsite: www.jadeteta.comInstagram: @jadeteta

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Feng Zhang, a professor of neuroscience at MIT and a pioneering figure in gene editing, joins Peter to discuss his groundbreaking work in CRISPR technology, as well as his early contributions to optogenetics. In this episode, they explore the origins of CRISPR and the revolutionary advancements that have transformed the field of gene editing. Feng delves into the practical applications of CRISPR for treating genetic diseases, the importance of delivery methods, and the current successes and challenges in targeting cells specific tissues such as those in the liver and eye. He also covers the ethical implications of gene editing, including the debate around germline modification, as well as reflections on Feng's personal journey, the impact of mentorship, and the future potential of genetic medicine. We discuss: Feng's background, experience in developing optogenetics, and his shift toward improving gene-editing technologies [2:45]; The discovery of CRISPR in bacterial DNA and the realization that these sequences could be harnessed for gene editing [10:45]; How the CRISPR system fights off viral infections and the role of the Cas9 enzyme and PAM sequence [21:00]; The limitations of earlier gene-editing technologies prior to CRISPR [28:15]; How CRISPR revolutionized the field of gene editing, potential applications, and ongoing challenges [36:45]; CRISPR's potential in treating genetic diseases and the challenges of effective delivery [48:00]; How CRISPR is used to treat sickle cell anemia [53:15]; Gene editing with base editing, the role of AI in protein engineering, and challenges of delivery to the right cells [1:00:15]; How CRISPR is advancing scientific research by fast-tracking the development of transgenic mice [1:06:45]; Advantages of Cas13's ability to direct CRISPR to cleave RNA and the advances and remaining challenges of delivery [1:11:00]; CRISPR-Cas9: therapeutic applications in the liver and the eye [1:19:45]; The ethical implications of gene editing, the debate around germline modification, regulation, and more [1:30:45]; Genetic engineering to enhance human traits: challenges, trade-offs, and ethical concerns [1:40:45]; Feng's early life, the influence of the American education system, and the critical role teachers played in shaping his desire to explore gene-editing technology [1:46:00]; Feng's optimism about the trajectory of science [1:58:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube