Podcasts about Gleason

In this high-voltage episode of American Potential, host David From sits down with Rachel Gleason, Executive Director of the Pennsylvania Coal Alliance, to discuss the future of coal, the reliability of America's power grid, and the consequences of top-down energy policy. Gleason gives a behind-the-scenes look at how federal and state regulations have systematically dismantled coal-fired generation in Pennsylvania—once a powerhouse of domestic energy—and how some of the most reliable plants are now being forced offline by policies driven more by politics than reality. She explains how President Trump's recent executive orders are reversing course by removing oppressive regulations and restoring the planning certainty needed to invest in energy production again. From the Clean Power Plan to the Mercury and Air Toxics Standards, Rachel details the flawed data and hidden costs behind these rules and how they've crippled long-term investment in reliable, base-load energy. She also covers the ongoing legal battle over Pennsylvania's attempt to join the Regional Greenhouse Gas Initiative (RGGI)—a de facto carbon tax that could raise costs while other states like Maryland simply import energy they refuse to produce. Gleason and From also examine the growing energy demand from AI and data centers, and why intermittent renewables and small nuclear reactors aren't ready to meet that need. Gleason makes a strong case for a diversified, “all-of-the-above” energy approach—one where coal continues to play a vital role in national security, economic growth, and grid reliability. If you care about affordable energy, American jobs, and ending the political war on coal, this episode is essential listening.

In this episode, the focus is on former President Joe Biden's prostate cancer diagnosis. Lisa and Dr. Nicole Saphier discuss the implications of Biden's health on his presidency. Dr. Saphier explains the seriousness of Biden's Gleason score, indicating an aggressive form of cancer, and questions the transparency of his health reports. The episode also touches on the potential political ramifications and the need for greater transparency in the health disclosures of public officials. The Truth with Lisa Boothe is part of the Clay Travis & Buck Sexton Podcast Network - new episodes debut every Tuesday & Thursday. Listen and Subscribe to Dr. Saphier's NEW Podcast HERE See omnystudio.com/listener for privacy information.

On Sunday, news broke that former President Joe Biden was diagnosed with an aggressive form of prostate cancer, characterized by a Gleason score of 9 and metastasis to the bone. This has raised a scandal -- how long ago did Biden's inner circle know of this diagnosis? Who was running the country as we saw our commander-in-chief's deterioration? Were his medical secrets, including his cognitive decline, so shielded from public eyes that his medical team covered up important test results? Ground Zero with Clyde Lewis from 7-10 pm, Pacific time on groundzeroplus.com. Call in to the LIVE show at 503-225-0860. #groundzeroplus #ClydeLewis #JoeBiden #prostatecancer

On Today's Episode: Joe Biden has prostate cancer and Michelle has zero idea what a Gleason score is.... John Hinkley, who tried to kill Reagan, dropped a new album and it sold out. Weird things people collect. The City of Detroit and other major cities are sinking...why? Why are we calling Travis "The Vanilla Gorilla?" If you enjoy the show please consider subscribing to our youtube channel, our podcast and newsletter.  

In this jam-packed episode of Badlands Daily, CannCon and Ghost tackle the geopolitical chessboard reshaped by Trump's triumphant Middle East tour. From trillion-dollar investment deals to the snub heard 'round the world, Trump's strategic bypass of Netanyahu signals a seismic shift in the U.S.-Israel relationship. Ghost breaks down the symbolic sword dances, economic alliances with MBS and Qatar, and what it all means for the emerging sovereign order. Meanwhile, back in the States, Biden's Gleason-9 prostate cancer diagnosis raises serious red flags. The hosts question the timing, transparency, and potential narrative utility of the announcement, especially in light of the devastating Robert Hur tapes and Biden's cognitive decline. They also explore the AutoPen scandal, Jill Biden's rumored revenge arc, and how the Democrats may be preparing a scorched-earth exit. The show hits everything from Trump's peace-brokering ambitions in Ukraine and Syria to bizarre Supreme Court rulings, DOJ shake-ups, and rumors of rogue North Korean special forces liberating Africa. Add in some spicy media takedowns, international election interference, and birthday celebrations for Ghost, and you've got one hell of an episode.

US former president Joe Biden was diagnosed with aggressive form of prostate cancer on Friday, said a statement from his personal office on Sunday.据美国前总统乔·拜登办公室周日发布的声明，现年82岁的拜登于周五被确诊患有恶性前列腺癌。The cancer, characterized by a Gleason score of 9 (Grade Group 5), has metastasized to the bone, said the statement.医学报告显示，该癌症的格里森评分高达9分（5级组），且已经转移到了骨骼。Earlier, Biden reported urinary symptoms, which led doctors to find a "small nodule" on his prostate.声明指出，此前拜登因泌尿系统症状加剧就医检查，医生在其前列腺部位发现一个“小结节”。"While this represents a more aggressive form of the disease, the cancer appears to be hormone-sensitive which allows for effective management," said the statement.虽然该癌症属于侵袭性较强的类型，但似乎对激素比较敏感，可进行有效管理。"The president and his family are reviewing treatment options with his physicians," added the statement.“拜登总统及其家人正在与医疗团队共同评估治疗方案”，声明补充道。Aged 82, Biden served as US President from January 2021 to January 2025 as the oldest-serving president in the history of the United States.作为美国历史上最高龄的总统，拜登曾于2021年1月至2025年1月期间执掌白宫。prostate cancer前列腺癌 urinary/ˈjʊərɪnəri/adj.泌尿的；泌尿器官的metastasized/mɪˈtæstəˌsaɪz/v.（癌）转移；扩散Gleason score前列腺癌评分；Gleason评分

Michael wishes Godspeed to President Joe Biden. According to a statement released by his personal office on Sunday, former President Joe Biden was diagnosed with an "aggressive form" of prostate cancer that has spread to his bones. He received This prostate cancer diagnosis on Friday, with a Gleason score of 9. Original air date 19 May 2025.

Biggest Scandal In HIstory! It Wasn't Just Dementia, Joe Biden Lied About Cancer TooLive show Monday-Thursday, 3pm est. SOCIALS: https://linktr.ee/drewberquist NEWS: https://DrewBerquist.com MERCH: https://RedBeachNation.com#DrewBerquist #ThisIsMyShow #TIMSTop 100 Political News Podcast with https://www.millionpodcasts.com/political-news-podcasts/Show Notes/Links:Guest: Author Matt PalumboThe Heir: Inside the (Not So) Secret Network of Alex SorosPre-order the book here: https://a.co/d/bNxPCORDoctor tells Joe Scarborough on MSNBC Biden has had this cancer a long timehttps://x.com/amuse/status/1924436941166022761Flashback: Biden slips and says he has cancer in 2022https://x.com/WCdispatch_/status/1924209033113649174Media defended him forever, said he was sharp and focusedhttps://x.com/adamcarolla/status/1923782303173808471 Fox News suggests Jake Tapper and Alex Thompson postpone book releasehttps://x.com/CalltoActivism/status/1924283467224748417Kash: FBI leaving Hoover Buildinghttps://x.com/nicksortor/status/1923363622471786965Kash Patel announces new evidence linked to the Russiagate hoax has been found https://x.com/bennyjohnson/status/1924117458115231798Hillary Clinton slams Trump for insisting women produce more childrenhttps://x.com/LeadingReport/status/1924107116136091997

This is the Catchup on 3 Things by The Indian Express and I'm Flora Swain.Today is the 19th of May and here are the headlines.1. Supreme Court Rejects Minister's Apology Over Remarks on Colonel Sofiya QureshiThe Supreme Court on Monday rejected Madhya Pradesh Minister Vijay Shah's apology over offensive remarks allegedly directed at Colonel Sofiya Qureshi. The court ordered a Special Investigation Team (SIT) to probe the matter and stayed Shah's arrest until a status report is submitted on May 28. Criticizing Shah, the bench said, “The entire nation is ashamed.” Shah made controversial comments during a speech near Mhow, indirectly referencing Qureshi. The SIT, to be led by an IG-rank officer, must be formed by 10 am Tuesday, per SC instructions.2. India Foils Drone, Missile Attack on Golden Temple by PakistanThe Indian Army revealed Monday that Pakistan attempted a drone and missile strike on Amritsar's Golden Temple and cities across Punjab on May 7–8, following Indian strikes on terrorist camps under Operation Sindoor. At a press event in Amritsar, the Army displayed debris from intercepted drones and missiles. Indian air defense systems, including upgraded L-70 guns and AKASH missiles, neutralized the threats. Officials emphasized the target was religious and civilian sites, underlining Pakistan's retaliatory intent following India's counter-terrorism operation inside Pakistani territory and Pakistan-occupied Kashmir.3. BCCI Pulls Out of ACC Events Amid India-Pakistan TensionsAmid escalating India-Pakistan tensions, the BCCI has decided to withdraw from upcoming Asian Cricket Council (ACC) tournaments, including the Women's Emerging Teams Asia Cup and Men's Asia Cup. The ACC is currently chaired by Pakistan's Interior Minister Mohsin Naqvi, which sources say contributed to India's decision. The move reflects India's intent to diplomatically isolate Pakistan's cricket board. The decision could impact the Asia Cup's feasibility, given the financial weight India brings to global cricket events. Sponsors and broadcasters may also reconsider deals if India stays out of the tournament.4. Bengaluru Faces Waterlogging After Year's Heaviest RainfallHeavy rain lashed Bengaluru for over six hours on Sunday night, causing widespread waterlogging and traffic disruptions across the city. Residents described it as the most intense rainfall of the year. Kengeri recorded the highest with 132 mm, according to the Karnataka State Disaster Monitoring Cell. The IMD has issued a ‘yellow alert' for the week, warning of more rain. Traffic police issued advisories for areas in northern Bengaluru including New Bel Road, Yelahanka Circle, Nagawara, and Allalasandra, as commuters dealt with long delays and flooded roads.5. Former President Joe Biden Diagnosed with Advanced Prostate CancerFormer U.S. President Joe Biden has been diagnosed with an aggressive form of prostate cancer, his office confirmed Sunday. Doctors reported a Gleason score of 9 (Grade Group 5), indicating metastasis to the bones, but added that the cancer appears hormone-sensitive, offering some treatment hope. Biden, who left office in January, is undergoing evaluations for further management. Global leaders, including Donald Trump and Indian Prime Minister Narendra Modi, expressed their support. Biden's diagnosis adds a personal and public health dimension to the global conversation on cancer awareness.That's all for today. This was the Catchup on 3 Things by The Indian Express.

Dr. Jeff Bohmer, Medical Director of the Emergency Department at Northwestern Medicine Central DuPage Hospital, joins Bob Sirott to talk about former President Biden’s prostate cancer diagnosis, including what some of his symptoms might have been and explains what a Gleason score is. He also discusses recent GLP-1 weight loss drug findings and how you […]

El expresidente Biden tiene un cáncer agresivo según el puntaje en la escala de Gleason, el método utilizado para medir uno de los cánceres más comunes entre los hombres en EE.UU.

Russell St. George, retired welder, plays with fire Any band would relish having a cheerleader like Shirley Maloney. At a recent show by Last Minute Soulmates at the Towne Crier in Beacon, she acted out the words, exhorted the crowd to sing along and pounded on tables during the final song, a funky cover of "Sweet Dreams (Are Made of This)." A good portion of the rowdy crowd almost reached Maloney's level of enthusiasm. House staff created an impromptu dance floor by clearing tables near the stage as people swung their partners with elbows locked together during "Maggie's Farm" and danced in circles during a heavy version of "Hound Dog." At one point, two men started screaming, ostensibly out of joy. The group's founder, Russell St. George, moved to town in 1986 and is a dean of Beacon's music scene. He focuses on original songs but likes to mix in atypical versions of covers, including "Your Cheating Heart" as a deliberate shuffle. "I'm not good enough to play them like the record, but I do like to shake things up with the arrangement or approach," he says. "And I still write, including songs about what's going on, like one about gun violence called 'When's it Gonna Stop?' " His originals, some of which feature a reggae tinge, keep things simple and rely on hooky choruses that get people singing. At one point, almost the entire audience, including the waitstaff, belted out the words. Working as a welder in Peekskill, a job he held for 37 years, St. George heard that houses in Beacon could be had on the cheap. His first local band, Daarc Ages (an acronym of members' first names), released a couple of CDs and opened for Dee Snider, Uriah Heap and Blue Oyster Cult at The Chance in Poughkeepsie and other venues. "We'd make a CD and someone would quit, so we had to keep finding musicians and never really got off the ground," he says. "Besides, I was kind of shy." That's odd because he sports flowing hair, a goatee and moustache. His fashion sense includes hats, big round glasses and black, accented with scarves, a look that leans more toward the hippie camp than the blue-collar world. Over the years, he played every local venue and hosted a 17-year monthly jam at Joe's Irish Pub (now MoMo Valley) that he called St. George and Friends. "The whole time, I never missed a date," he says. "But I turned 60, COVID hit and the end arrived." Last Minute Soulmates started as an acoustic duo that grew into an electric project by 2011. Self-effacing, he credits band members for any success. Not shy about his left-leaning political views, he lost some followers over the years. He feels no compulsion to record his new tunes, in part because working in the studio is a drag compared to playing for a responsive audience. "Streams and other delivery systems don't get a lot of traction," he says. "If people want to hear my songs in their best light, come see me live." Last Minute Soulmates, with St. George (vocals, guitar), Carla Springer (vocals), Rik Mercaldi (guitar), Harry Lawrence (bass) and Mitch Florian (drums), will perform at 9 p.m. on May 23 at Gleason's, 23 S. Division St., in Peekskill.

In "Episode 3" of the series on "Present and future of diagnostics in prostate cancer", Assoc. Prof. Paweł Rajwa (PL) and Prof. Scott Eggener (US) engage in a thought-provoking discussion about renaming Gleason 6 (Grade Group 1) prostate cancer.The episode digs into the reasons why many experts believe this change is necessary, and the potential benefits it could bring to clinical practice, particularly in reducing overdiagnosis/overtreatment and improving patient outcomes. Prof. Eggener discusses the argument that Gleason 6 (Grade Group 1) might not behave like typical cancer, as it rarely leads to metastasis or death, and that renaming it could positively guide management decisions, particularly with active surveillance.The conversation touches on the implications of this change on prostate cancer screening and how it could alter the way clinicians approach diagnosis and treatment in the future.For more EAU podcasts, please go to your favourite podcast app and subscribe to our podcast channel for regular updates: Apple Podcasts, Spotify, EAU YouTube channel.

On this episode of The Downtown, we talk to Sean Gleason with PBR! PBR returns to the metroplex starting this Thursday in Fort Worth with the World Finals happening May 17 and 18th at AT&T Stadium. We also hear local music from Almost Jaded with their song “Not Over You.” Apple Podcasts - https://tinyurl.com/yf2yk2jzGoogle Podcasts - https://tinyurl.com/ybuxuvymSpotify - https://tinyurl.com/yh4xbgvuPodcast Addict- https://tinyurl.com/y9d7qcpySpreaker - https://www.spreaker.com/user/arlingtoncitizenmedia

With the PBR World Finals kicking off May 8, it was the perfect time to sit down with Sean Gleason, CEO of the PBR. In this episode, Ted Stovin and Sean dive into all things bull riding—from Kid Rock's Rock N Rodeo and the potential Olympic future of the sport, to prize money, the team season, and everything in between. Huge thanks to Brahma Boots for the new studio set up! If you enjoyed the show, don't forget to leave a rating and review! Catch the video version on YouTube at Everythingcowboy.com And for all things cowboy shit including apparel, head over to cowboyshit.ca  

One of the biggest podcasts each year, IL's Terry Foy reacts to the bracket selection, welcoming in: • NCAA Committee Chair Matthew Colagiovanni • Harvard coach Gerry Byrne • Colgate coach Matt Karweck • Siena coach Liam Gleason Colagiovanni discusses how the Committee evaluated Harvard vs. Army, the decision to send Notre Dame to Ohio State and more. Byrne lays out what it's like for this group to get back to the Tournament and head back to the Dome to play a team they already beat. Karweck lays out how taxing and gratifying the last 10 days have been. And Gleason reflects on the work that went into getting the Saints back to the Tournament and what it'll be like to play against his alma mater. This year, Inside Lacrosse is proud to partner with the NCAA to offer you, our loyal listeners, $5 off all single-day ticket options (men and women) by using the code ILPOD at checkout. So head to NCAA.com/LaxTickets and enter ILPOD at checkout to purchase your tickets. You know you're going to go to Championship Weekend, so why not get $5 off and help us show the NCAA how awesome our listeners are by purchasing your tickets today.

Readings: Acts 9:1-20 | Revelation 5:11-14 | John 21:1-19 | Psalm 30. Preached for the Third Sunday of Easter (2024-05-04).

Prayer is not prescriptive. So how could we hope to teach our children a practice that St. Thérèse called “a surge of the heart”? Lower school head Colin Gleason suggests that it's about creating opportunities and options, so that our sons can naturally make a life of prayer their own. In his talk from our Parenting Conference in April, Mr. Gleason lays out ten very practical ways to sow the seeds of prayer into our family's daily routines—in formal and spontaneous ways. He ends by reminding us that prayer is not a program. It is an orientation. And whatever we parents approach with consistency and sincerity, “the house will be filled with the fragrance of it” (cf. John 12:3). Chapters: 00:05:28 Prayer as a relationship 00:09:53 A family plan for daily prayer 00:12:30 Introducing them to mental prayer 00:15:00 The Psalms: a handbook 00:20:37 Making opportunities and options 00:24:20 Asking them to pray for us 00:26:57 Stories for the prayer imagination 00:29:52 Prayer journals 00:31:07 Discussing prayer 00:32:46 Prayer in our daily activities 00:35:27 Making a prayer spot 00:37:32 Clearing obstacles, preparing the ground Featured opportunities: Teaching Essentials Workshop at The Heights School (June 16-20, 2025) Convivium for Teaching Men at The Heights School (November 13-15, 2025) Also on the Forum: Forming Men of Faith by Alvaro de Vicente Forming Families, Forming Saints featuring Fr. Carter Griffin

Send us a text“It used to take 40 minutes, now it takes 15” - this is what Dr. Alae Kawam said about her AI-powered prostate biopsy evaluation workflow.  In this energizing episode of the Digital Pathology Podcast recorded at PathVisions 2024, Dr. Alae Kawam joins me to reflect on where pathology is headed—from AI-assisted prostate diagnostics to direct-to-digital imaging and beyond. Together, we unpack what's working, what still feels clunky, and why standardization, staffing flexibility, and smarter AI are critical to the next phase of pathology adoption.

Sean Gleason joins Tommy and Kendra for their 20 year work reunion and to talk about the PBR.Send us a textSend your thoughts and feedback to nospinfeedback@gmail.com or text 817-668-2395

Readings: Isaiah 65:17-25 | Psalm 118:1-2, 14-24 | Acts 10:34-43 | Luke 24:1-12. Preached for Easter Sunday (2025-04-20).

Matt is joined by Darold Gleason to talk about their recent trip to Columbia County, Georgia and Clarks Hill Lake (along with the Masters).  In the second half of the show, the always positive Charlie Hartley jumps on to talk about the Open in Mississippi.  

It's taken a bit of time for Chris to get on board with the year of the Stitch-up, but this week he's fully on board with the pick, Smokey and the Bandit 3. The production of Smokey and the Bandit Part 3 (1983) was plagued by confusion, last-minute changes, and a noticeable lack of direction—both literally and creatively. Initially conceived as Smokey IS the Bandit, the film was supposed to center entirely around Jackie Gleason playing both Sheriff Buford T. Justice and the Bandit himself. Universal even shot a version of the film under this premise, but test audiences were so baffled by the concept that the studio pulled the plug and hastily reshot large portions of the film, reinstating Jerry Reed's Cledus "Snowman" Snow as the new Bandit. Burt Reynolds, whose charisma had anchored the first two entries, wanted no part of the third film and only appeared in a brief cameo, further cementing the sense that the magic of the original was long gone.Behind the scenes, the budget was slashed and the enthusiasm of the cast and crew matched it. Gleason, a comedic titan, was reportedly frustrated with the rewrites and changes, and his performance suffered under the weight of a poorly conceived script. The film's tone teetered awkwardly between slapstick and tired repetition, and critics pounced on it for lacking the heart, fun, and chemistry of its predecessors. Despite all this, Smokey and the Bandit Part 3 did manage to close out the trilogy—albeit with a screech rather than a roar—serving as a cautionary tale of how a franchise can run out of gas when it loses its original spark.If you enjoy the show we have a Patreon, so become a supporter.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.patreon.com/thevhsstrikesback⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Trailer Guy Plot SummaryIn a world where bootlegging beer is out and hauling stuffed fish is in, one retired sheriff is about to hit the road... one last time. When Big Enos and Little Enos cook up a cross-country prank, Sheriff Buford T. Justice takes the bait—literally—hauling a prized fish from Florida to Texas. But there's a twist... Cledus “Snowman” Snow steps into the Bandit's boots to turn the tables and reclaim the legend. Now, it's a high-octane race filled with car crashes, barroom brawls, and enough denim to clothe a small town. Smokey and the Bandit Part 3—because when the Bandit's away, the Smokey will play.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠thevhsstrikesback@gmail.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://linktr.ee/vhsstrikesback⁠

JCO PO author Dr. Timothy Showalter at Artera and University of Virginia shares insights into his JCO PO article, “Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer” . Host Dr. Rafeh Naqash and Dr. Showalter discuss how multimodal AI as a prognostic marker in nonmetastatic castration-resistant prostate cancer may serve as a predictive biomarker with high-risk patients deriving the greatest benefit from treatment with apalutamide. TRANSCRIPT  Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations where we'll bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast Editor for JCO Precision Oncology and assistant professor at the OU Health Stephenson Cancer Center at the University of Oklahoma. Today, we are excited to be joined by Dr. Timothy Showalter, Chief Medical Officer at Artera and professor of Radiation Oncology at the University of Virginia and author of the JCO Precision Oncology article entitled, “Digital Pathology Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase 3 Trial in Men with Non-Metastatic Castration Resistant Prostate Cancer.” At the time of this recording, our guest's disclosures will be linked in the transcript. Dr. Showalter, it's a pleasure to have you here today. Dr. Timothy Showalter: It's a pleasure to be here. Thanks for having me. Dr. Rafeh Naqash: I think this is going to be a very interesting discussion, not just from a biomarker perspective, but also in terms of how technologies have evolved and how we are trying to stratify patients, trying to escalate or deescalate treatments based on biomarkers. And this article is a good example of that. One of the things I do want to highlight as part of this article is that Dr. Felix Feng is the first author for this article. Unfortunately, Dr. Felix Feng passed away in December of 2024. He was a luminary in this field of prostate cancer research. He was also the Chair of the NRG GU Committee as well as Board of Directors for RTOG Foundation and has mentored a lot of individuals from what I have heard. I didn't know Dr. Feng but heard a lot about him from my GU colleagues. It's a huge loss for the community, but it was an interesting surprise for me when I saw his name on this article as I was reviewing it. Could you briefly talk about Dr. Feng for a minute and how you knew him and how he's been an asset to the field? Dr. Timothy Showalter: Yeah. I'm always happy to talk about Felix whenever there's an opportunity. You know, I was fortunate to know Felix Feng for about 20 years as we met during our residency programs through a career development workshop that we both attended and stayed close ever since. And you know, he's someone who made an impact on hundreds of lives of cancer researchers and other radiation oncologists and physicians in addition to the cancer patients he helped, either through direct clinical care or through his innovation. For this project in particular, I first became involved soon after Felix had co-founded Artera, which is, you know the company that developed this. And because Felix was such a prolific researcher, he was actually involved in this and this research project from all different angles, both from the multimodal digital pathology tool to the trial itself and being part of moving the field forward in that way. It's really great to be able to sort of celebrate a great example of Felix's legacy, which is team science, and really moving the field forward in terms of translational projects based on clinical trials. So, it's a great opportunity to highlight some of his work and I'm really happy to talk about it with you. Dr. Rafeh Naqash: Thanks, Tim. Definitely a huge loss for the scientific community. And I did see a while back that there was an international symposium organized, showcasing his work for him to talk about his journey last year where more than 200, 250 people from around the globe actually attended that. That speaks volumes to the kind of impact he's had as an individual and impact he's had on the scientific side of things as well. Dr. Timothy Showalter: Yes. And we just had the second annual Feng Symposium the day before ASCO GU this year with, again, a great turnout and some great science highlighted, as well as a real focus on mentorship and team science and collaboration. Dr. Rafeh Naqash: Thank you so much for telling us all about that. Now going to what you guys published in JCO Precision Oncology, which is this article on using a biomarker approach to stratify non-metastatic prostate cancer using this artificial intelligence based H&E score. Could you tell us the background for what started off this project? And I see there is a clinical trial data set that you guys have used, but there's probably some background to how this score or how this technology came into being. So, could you superficially give us an idea of how that started? Dr. Timothy Showalter: Sure. So, the multimodal AI score was first published in a peer reviewed journal back in 2022 and the test was originally developed through a collaboration with the Radiation Therapy Oncology Group or Energy Oncology Prostate Cancer Research Team. The original publication describes development and validation of a risk stratification tool designed to predict distant metastasis and prostate cancer specific mortality for men with localized prostate cancer. And the first validation was in men who were treated with definitive radiation therapy. There have been subsequent publications in that context and there's a set of algorithms that have been validated in localized prostate cancer and there's a test that's listed on NCCN guidelines based on that technology. The genesis for this paper was really looking at extending that risk stratification tool that was developed in localized prostate cancer to see if it could one, validate in a non-metastatic castrate refractory prostate cancer population for patients enrolled on the SPARTAN trial. And two, whether there was a potential role for the test output in terms of predicting benefit from apalutamide for patients with non-metastatic prostate cancer. For patients who are enrolled on the SPARTAN study, almost 40% of them had H&E stain biopsy slide material available and were eligible to be included in this study. Dr. Rafeh Naqash: Going a step back to how prostate cancer, perhaps on the diagnostic side using the pathology images is different as you guys have Gleason scoring, which to the best of my knowledge is not necessarily something that most other tumor types use. Maybe Ki-67 is somewhat of a comparison in some of the neuroendocrine cancers where high Ki-67 correlates with aggressive biology for prognosis. And similarly high Gleason scores, as we know for some of the trainees, correlates with poor prognosis. So, was the idea behind this based on trying to stratify or sub-stratify Gleason scoring further, where you may not necessarily know what to do with the intermediate high Gleason score individual tumor tissues? Dr. Timothy Showalter: Well, yeah. I mean, Gleason score is a really powerful risk stratification tool. As you know, our clinical risk groupings are really anchored to Gleason scores as an important driver for that. And while that's a powerful tool, I think, you know, some of the original recognition for applying computer vision AI into this context is that there are likely many other features located in the morphology that can be used to build a prognostic model. Going back to the genesis of the discovery project for the multimodal AI model, I think Felix Feng would have described it as doing with digital pathology and computer vision AI what can otherwise be done with gene expression testing. You know, he would have approached it from a genomic perspective. That's what the idea was. So, it's along the line of what you're saying, which is to think about assigning a stronger Gleason score. But I think really more broadly, the motivation was to come up with an advanced complementary risk stratification tool that can be used in conjunction with clinical risk factors to help make better therapy recommendations potentially. So that was the motivation behind it. Dr. Rafeh Naqash: Sure. And one of the, I think, other important teaching points we try to think about, trainees of course, who are listening to this podcast, is trying to differentiate between prognostic and predictive scores. So, highlighting the results that you guys show in relation to the MMAI score, the digital pathology score, and outcomes as far as survival as well as outcomes in general, could you try to help the listeners understand the difference between the prognostic aspect of this test and the predictive aspect of this test? Dr. Timothy Showalter: So let me recap for the listeners what we found in the study and how it kind of fits into the prognostic and the predictive insights. So, one, you know, as I mentioned before, this is ultimately a model that was developed and validated for localized prostate cancer for risk stratification. So, first, the team looked at whether that same tool developed in localized prostate cancer serves as a prognostic tool in non-metastatic castrate-refractory prostate cancer. So, we applied the tool as it was previously developed and identified that about 2/3 of patients on the SPARTAN trial that had specimens available for analysis qualified as high risk and 1/3 of patients as either intermediate or low risk, which we called in the paper ‘non-high risk'. And we're able to show that the multimodal AI score, which ranges from 0 to 1, and risk group, was associated with metastasis free survival time to second progression or PFS 2 and overall survival. And so that shows that it performs as a prognostic tool in this setting. And this paper was the first validation of this tool in non-metastatic castrate-refractory prostate cancer. So, what that means to trainees is basically it helps you understand how aggressive that cancer is or better stratify the risk of progression over time. So that's the prognostic performance. Dr. Rafeh Naqash: Thank you for trying to explain that. It's always useful to get an example and understand the difference between prognostic and predictive. Now again, going back to the technology, which obviously is way more complicated than the four letter word MMAI, I per se haven't necessarily done research in this space, but I've collaborated with some individuals who've done digital pathology assessments, and one of the projects we worked on was TIL estimation and immune checkpoint related adverse events using some correlation and something that one of my collaborators had sent to me when we were working on this project as part of this H&E slide digitalization, you need color deconvolution, you need segmentation cell profiling. Superficially, is that something that was done as part of development of this MMAI score as well? Dr. Timothy Showalter You need a ground truth, right? So, you need to train your model to predict whatever the outcome is. You know, if you're designing an AI algorithm for Ki-67 or something I think you mentioned before, you would need to have a set of Ki-67 scores and train your models to create those scores. In this case, the clinical annotation for how we develop the multimodal AI algorithm is the clinical endpoints. So going back to how this tool was developed, the computer vision AI model is interpreting a set of features on the scan and what it's trying to do is identify high risk features and make a map that would ultimately predict clinical outcomes. So, it's a little bit different than the many digital pathology algorithms where the AI is being trained to predict a particular morphological finding. In this case, the ground truth that the model is trained to predict is the clinical outcome. Dr. Rafeh Naqash: Sure. And from what you explained earlier, obviously, tumors that had a high MMAI score were the ones that were benefiting the most from the ADT plus the applausive. Is this specific for this androgen receptor inhibitor or is it interchangeable with other inhibitors that are currently approved? Dr. Timothy Showalter: That's a great question and we don't know yet. So, as you're alluding to, we did find that the MMAI risk score was predictive for benefit from apalutamide and so it met the statistical definition of having a significant interaction p value so we can call it a predictive performance. And so far, we've only looked in this population for apalutamide. I think you're raising a really interesting point, which is the next question is, is this generalizable to other androgen receptor inhibitors? There will be future research looking at that, but I think it's too early to say. Just for summary, I think I mentioned before, there are about 40% of patients enrolled on the SPARTAN study had specimens available for inclusion in this analysis. So, the SPARTAN study did show in the entire clinical trial set that patients with non-metastatic castrate-refractory prostate cancer benefited from apalutamide. The current study did show that there seems to be a larger magnitude of benefit for those patients who are multimodal AI high risk scores. And I think that's very interesting research and suggests that there's some interaction there. But I certainly would want to emphasize that we have not shown that patients with intermediate or low risk don't benefit from apalutamide. I think we can say that the original study showed that that trial showed a benefit and that we've got this interesting story with multimodal AI as well. Dr. Rafeh Naqash: Sure. And I think from a similar comparison, ctDNA where ctDNA shows prognostic aspects, I treat people with lung cancer especially, and if you're ctDNA positive at a 3 to 4-month period, likely chances of you having a shorter disease-free interval is higher. Same thing I think for colorectal cancers. And now there are studies that are using ctDNA as an integral biomarker to stratify patients positive/negative and then decide on escalation/de-escalation of treatment. So, using a similar approach, is there something that is being done in the context of the H&E based stratification to de-intensify or intensify treatments based on this approach? Dr. Timothy Showalter: You're hitting right on the point in the most promising direction. You know, as we pointed out in the manuscript, one of the most exciting areas as a next step for this is to use a tool like this for stratification for prospective trials. The multimodal AI test is not being used currently in clinical trials of non-metastatic castrate-refractory prostate cancer, which is a disease setting for this paper. There are other trials that are in development or currently accruing where multimodal AI stratification approach is being taken, where you see among the high-risk scores, at least in the postoperative setting for a clinical trial that's open right now, high risk score patients are being randomized to basically a treatment intensification question. And then the multimodal AI low risk patients are being randomized to a de-intensification experimental arm where less androgen deprivation therapy is being given. So, I think it's a really promising area to see, and I think what has been shown is that this tool has been validated really across the disease continuum. And so, I think there are opportunities to do that in multiple clinical scenarios. Dr. Rafeh Naqash: Then moving on to the technological advancements, very fascinating how we've kind of evolved over the last 10 years perhaps, from DNA based biomarkers to RNA expression and now H&E. And when you look at cost savings, if you were to think of H&E as a simpler, easier methodology, perhaps, with the limitations that centers need to digitalize their slides, probably will have more cost savings. But in your experience, as you've tried to navigate this H&E aspect of trying to either develop the model or validate the model, what are some of the logistics that you've experienced can be a challenge? As we evolve in this biomarker space, how can centers try to tackle those challenges early on in terms of digitalizing data, whether it's simple data or slides for that matter? Dr. Timothy Showalter: I think there's two main areas to cover. One, I think that the push towards digitalization is going to be, I think, really driven by increasing availability and access to augmentative technologies like this multimodal AI technology where it's really adding some sort of a clinical insight beyond what is going to be generated through routine human diagnostic pathology. I think that when you can get these sorts of algorithms for patient care and have them so readily accessible with a fast turnaround time, I think that's really going to drive the field forward. Right now, in the United States, the latest data I've seen is that less than 10% of pathology labs have gone digital. So, we're still at an early stage in that. I hope that this test and similar ones are part of that push to go more digital. The other, I think, more interesting challenge that's a technical challenge but isn't about necessarily how you collect the data, but it certainly creates data volume challenges, is how do you deal with image robustness and sort of translating these tools into routine real-world settings. And as you can imagine, there's a lot of variation for staining protocols, intensity scanner variations, all these things that can affect the reliability of your test. And at least for this research group that I'm a part of that has developed this multimodal AI tool can tell you that the development is sophisticated, but very data and energy intensive in terms of how to deal with making a tool that can be consistent across a whole range of image parameters. And so that presents its own challenges for dealing with a large amount of compute time and AI cycles to make robust algorithms like that. And practically speaking, I think moving into other diseases and making this widely available, the size of data required and the amount of cloud compute time will be a real challenge. Dr. Rafeh Naqash: Thank you for summarizing. I can say that definitely, you know, this is maybe a small step in prostate cancer biomarker research, but perhaps a big step in the overall landscape of biomarker research in general. So definitely very interesting. Now, moving on to the next part of the discussion is more about you as a researcher, as an individual, your career path, if you can summarize that for us. And more interestingly, this intersection between being part of industry as well as academia for perhaps some of the listeners, trainees who might be thinking about what path they want to choose. Dr. Timothy Showalter: Sure. So, as you may know, I'm a professor at the University of Virginia and I climbed the academic ladder and had a full research grant program and thought I'd be in academia forever. And my story is that along the way, I kind of by accident ended up founding a medical device company that was called Advaray and that was related to NCI SBIR funding. And I found myself as a company founder and ultimately in that process, I started to learn about the opportunity to make an impact by being an innovator within the industry space. And that was really the starting point for me. About four years ago, soon after Felix Feng co-founded Artera, he called me and told me that he needed me to join the company. For those who were lucky to know Felix well, at that very moment, it was inevitable that I was going to join Artera and be a part of this. He was just so persuasive. So, I will say, you know, from my experience of being sort of in between the academic and industry area, it's been a really great opportunity for me to enter a space where there's another way of making an impact within cancer care. I've gotten to work with top notch collaborators, work on great science, and be part of a team that's growing a company that can make technology like this available. Dr. Rafeh Naqash: Thank you so much, Tim, for sharing some of those thoughts and insights. We really appreciate you discussing this very interesting work with us and also appreciate you submitting this to JCO Precision Oncology and hopefully we'll see more of this as this space evolves and maybe perhaps bigger more better validation studies in the context of this test. Thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcast.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

We're back for SEASON 5! We know... its been a while, so we have a very special guest joining us - Darby Gleason.

DATE: April 8, 2025SHOW: Prelude to PositivityProducer: Tommy GeraciHOST: Tommy GeraciGUEST: ⁠Brett GleasonWith unflinching candor & literary precision,Brett Gleason reveals his perspective as a gay man with bipolar disorder through music that transforms tender ballads into soaring epic moments.While his piano-based songwriting & soulful tenor remain constant, Brett's ability to embrace a wide palette of soundscapes and emotions makes him a one-of-a-kind artist with comparisons to artists as diverse as Tori Amos, Trent Reznor & Rufus Wainwright.Gleason was born in Long Island, New York where a speech impediment would lead to a childhood immersed in the arts.At 17, he moved to New York City to study music and literature at the New School University.Now based in Los Angeles the multi-instrumentalist has produced 3 albums to critical acclaim.His new single, 'Sensory Deprived' is set to be released on April 8. InstagramSpotify

Readings: Isaiah 43:16-21 | Philippians 3:4b-14 | John 12:1-8 | Psalm 126. Preached for the Fifth Sunday in Lent (2025-04-06).

  Welcome to Hope for the Caregiver here on American Family Radio. This is Peter Rosenberger and I will be your host today through all things caregiver related. I've been a caregiver so long that the hospital Wi-Fi connects automatically. You know you've been a caregiver a long time when you call 911 and they say, Hey Peter, that's my life. I've been a caregiver so long my idea of vacation is waiting in the car during surgery. And even Siri whispers to me, bless your heart. We are still in Denver, in the hospital. And Gracie now has to go back into surgery on Monday or Tuesday. This left leg just does not want to heal up. This will be her 93rd and her 6th during this particular 10-week stretch we pulled. So yeah, I know a little bit about the journey. And I've learned a few things. I'm going to give you some practical things right now. Okay? Just some practical. We're going to get into some heavy stuff later on in the program. But I've got some practical things. One of them is when you're in an elevator. A couple of points in an elevator. For elevator etiquette. And it's not what you think. But it's... I always let ladies exit and enter the elevator before me. I hold the door and make sure they go in properly. I told one guy, there was a bunch of them, and this guy tried to go in. I said, no, you wait for me. I was raised in the South. I'll help the ladies, but I'm not going to help you. You're a grown man. I actually told him that on the elevator. I mean, I've spent a lot of time in the hospital. So these are things I observed. But a lot of people will line up in front of the elevator on the bottom floor. Now, why is that problematic? Why? Well, I'll tell you why. Because there are people going to be getting off that elevator, and they can't get off if there's some yahoo standing right in front of them. And I'm like, has it not occurred to you maybe to wait over to the side? Another thing is, don't be on speakerphone and having a conversation while on the elevator. I understand being on the phone. I'm often on Bluetooth, giving updates and so forth. But when I get on the elevator, I will tell whoever I'm talking to, I'm getting ready to get on the elevator. You keep talking, I'll listen. I got a buddy of mine I was talking to back in Montana. And I said, all right, I'm getting on the elevator. You talk, I'll listen. So he started asking me questions. And I'm like, you didn't understand the point. The point is, I'm getting on the elevator. I'm not going to talk. You talk, I'll listen. Well, what do you want me to talk about? Oh, for heaven's sakes. And so I just kind of, you know, but that's another thing. People get on the elevator and they got speakerphone going. And I'm like, I jump into the conversation sometimes, you know, figured it's there. It's a public conversation now. And then here's something else. And I'm not faulting you for this, but be aware that Be aware of a few things when you're walking into a hospital, into a corridor. Number one is if you're going around corners, drive in the right lane. Okay? Drive in the right lane. We're not in Great Britain. We're in America. Drive in the right lane. So hug the wall on your right side. So when you go around a corner, you're not doing like in NASCAR when you're getting way down low there. You got to go up a little high and come around because there's somebody else coming around that corner and they're driving in their right lane. I have been involved in many near collisions because people were hugging the left corner. Now, that may sound stupid to you, but you spend 10 weeks in a hospital, and then you come back and tell me what you think, okay? And this ain't my first 10 weeks in the hospital with Gracie. So these are things I observed that people are, this is a very big hospital, a lot of people, and everybody's busy, and I understand that. Here's another little tidbit. Situational awareness is everything. Be aware of how you are in space and in time as you're moving in and out of this labyrinth of of a place there where a lot of people are. People are very busy. This is, again, a teaching hospital. So it's very busy. It's always going 24-7. And you have to be aware of where you are in space and in time. Not just, you know... ambling along. I was on the elevator with two women, and they were older women, but not that old. Well, now that I think about it, they're probably younger than me, which, now that's just kind of sad, isn't it? They looked older, but I realized they're probably younger than me. Okay, well, all right, let me just go and cry over that one in the pantry. But Regardless, they were on the elevator and one of them had a walker and they were very nicely dressed. They were very pleasant ladies. And I held the door and they started walking. Well, I was in a bit of a hurry. And these two women, one of them was rather large. I mean, she wasn't gargantuan, but she's a big woman. And the other one was a bit hefty as well. And she had a walker, but a little, not a walker, but one of those things with wheels on it. You know what I'm talking about. And she would sit down and into the elevator and then get up and start moving. That's fine. I live with somebody with mobility impairments. I understand it. But I am always aware of Gracie and me in time and space. Always. When I'm walking anywhere with her, I'm aware of who's behind me, who's in front of me, who's to my left. I'm always aware of things like that. That's just the way I kind of Some of it's my martial arts training, check your six, always look around, head on a swivel. I get that. Some of it's just common courtesy and some of it is just, I just don't want somebody to run into me or me run into someone else. And these two women were ambling along for a little afternoon stroll. But they took up the entire corridor. You couldn't get around them. It was just not a space where I could. And they walked wide, and they were wide. And it wasn't just because of the one with the mobility device. It was just because they were big and clueless. And they went along at their stroll, and I had to go with their pace behind them. And I was in a bit of a hurry. I was like... You know, do you have to take up the entire hallway? You know, because there's always little carts or something on the side of the thing, and you can't easily pass in certain places. And, you know, crash carts and things such as that scattered around the corridor there. So it was like... And you say, you know, Peter, you're being petty. Well, yes, I am. But I've been here for 10 weeks, and I've just, you know... Move it, people. That's what I'm talking about. Thank you for that. That's what it feels like. I'm telling you, that's what it feels like. Move it, people. There's nothing like being in a hospital for a lengthy period of time to... force you into a different kind of, I don't know. But I never cease to be amazed on how people amble and stroll and mosey in a place where there's a high traffic area. And it's a bit jarring because I'm moving quickly. And I'm not just sitting there with Gracie all day long doing nothing. I mean, oh, I think I'll stretch my legs and go down to the cafeteria. I'm working. I have to work all the time. I mean, I don't have to work all the time, but I have to work I can't put my life on hold for 10 weeks. And I've written, by the way, I've written quite a bit here, 40,000 plus words since I've been here. Five published articles and I finished a new book that's going to be out next year. Got one coming out this summer and we'll talk about that. And then I've got a new book that'll be out next year that I think you're going to really like. But I've been working and then I've gotten shipments over to Africa and so forth. I mean, I work. And then I'm looking after her. I'm back and forth to the hospital frequently. I come to do this radio program. I do a live show on Wednesdays. And that's one of the reasons I went in a hurry that day because I had to get back over to the hotel across the street where I do a live show on Wednesday afternoons. And so I was, you know, wanting these women to move a little faster or at least move over, you know, just same thing as being on a highway. You don't go on the interstate at 30 miles an hour. And they just, you know, were clueless. I mean, truly clueless. And I see this a lot in the hospital. If you have to go into the hospital for an extended period of time, be aware that you're going to see high traffic areas and stay to the right. And don't stand right in front of an elevator blocking it so people on the elevator can't get off. You're not getting on unless they get off. And so give them space to maneuver. My father used to always say that. He said, keep moving forward, but give space to maneuver. That was one of his trademark lines. And he was such a student of observing people and their behaviors that he would probably chuckle at this. I don't know if you are, but I'm sorry. I just had to take this moment to vent out because I'm tired of running into people by the elevators and through the hallways of this hospital. Listen, we got more to go. This is Peter Rosenberger, Hope for the Caregiver, hopeforthecaregiver.com. We'll be right back. Thank you. Welcome back to Hope for the Caregiver. I am Peter Rosenberger, PeterRosenberger.com. PeterRosenberger.com. If you want to explore more of what I put out there for you as a family caregiver, I hope you'll take advantage of it. Right up at the top of the page, you say, check out Peter's Substack page. Well, what does that mean? Well, Substack is an online newsletter. And there are lots of different things that I put out there. You can put video and audio and print and so forth, and that's what I do. And On this page, my latest post is, what do you think? It's called What Do You Think? And it's from my book, A Minute for Caregivers, When Every Day Feels Like Monday. And I post these out every Monday. So if you go out today and subscribe to this, you'll get a missive on Monday to tell you about a new one. But right now, you can go out and read this today, look at it, and there's some other things out there. Some of it's behind a paywall, and you have to subscribe for that if that's your choice you want to do. But this I put out every Monday for free. And this is one I think that would connect deeply with you as a caregiver. I'll give you a bit of a preview of this, okay? And the concept behind it. That's the special bonus that you're going to get today on this program. Like I said, I've been here for a long time. I've devolved into elevator etiquette for a conversation topic. I mean, you get a little bit loopy here when you have these kinds of lengthy hospital stays. But I have often and embarrassingly inserted my opinion during Gracie's long medical journey. I know you're saying to yourself, no, Peter, that couldn't happen. You wouldn't give your opinion. You would be quiet and demure and genteel, and you would be a wallflower. I know you might think that. That may be your first inclination to go there, but... Let me dispel you of that and tell you that I have done this and I don't recall being frequently asked for my opinion, particularly by surgeons. Yet, as the team was observing Gracie's response during the recovery process of one of her surgeries, the lead surgeon looked at me and said, what do you think? All right, now think through that for just a moment. This guy is a serious surgeon, not a lightweight. You don't serve in this particular hospital, this teaching hospital. You don't serve in this capacity as a teacher, as the attending, unless you've got some real game to you. Let me just add, I don't let you work on my wife unless you have some real game to you. Okay? We're pretty hard on docs and surgeons. I had a resident tell me that, you know, I've never seen this before. They were looking at some stuff with Gracie and said, we've never seen this before. I looked at this surgeon and I said, you know, the first time I heard that from a surgeon, Ronald Reagan was president. And they couldn't believe it. I mean, they were stung it. They really don't know how to wrap their mind around that. So anyway, this surgeon looked at me, and he's not a lightweight surgeon. What do you think? Well, you know, four decades of living with Gracie, I understand nuances about her that no medical professional could ever hope to know. They don't have the kind of time to be brought up to speed on Gracie. I have a PhD in Gracie. And it came from the School of Hard Knocks. Most of them, she's knocked on my head. And I hear an amen from Gleason, Tennessee, where Betsy has just said amen. She listens to this program and she's saying amen. I've known Betsy and her husband Tommy for a very, very long time. They've known me since I was 14 or 15 years old. But anyway, the School of Hard Knocks, that's it. A lengthy list of unpleasant events, and I'm saying that with a great deal of diplomacy, has taught me and continues to teach me the value of keeping my opinion to myself and only sharing what I've witnessed and experienced to the best of my abilities. Now, sometimes it gets the best of me, I admit. But I try to stay with my experience. and what I've observed. So when the surgeon graciously sought my thoughts, I stayed on message. I shared what I've observed of my wife and her challenges and avoided speculating. Here's what I've observed. One of the things I've observed that post-operatively, when something can go wrong with a patient, it usually will go wrong with Gracie. That's what I've observed. And I went on to share with him some other things i've observed about her lengthy history nodding with understanding he ordered a few additional tests evidently in part based upon my response and he continued looking for solutions now as a caregiver i'm learning to stay in my lane i really am i don't Don't jump to conclusions that I'm not, even though I went on the whole elevator diatribe at the last block. I'm learning to stay in my lane while speaking with calm authority about what I know. recognizing that my experience is far worthier than my opinion. And I put a quote on there from Kurt Cobain. You may not know who he is. He's a particularly sad, tragic figure who was the lead singer, guitarist, songwriter for Nirvana, a very troubled young man who took his life when he was 27. He had been just a very sad, troubled man, but he was a very deep thinker. And he wrote something once that said, we have no right to express an opinion until we know all of the answers. And again, he was an extremely troubled young man. who sadly took his life. Many attempts tried to take his life before, dealt with drugs and so forth. But in the middle of his distress, he had such profound things that he said, the way he approached things. And I love that quote, we have no right to express an opinion until we know all the answers. And I think of my own life and how many times I have shot my mouth off with an opinion and I didn't even know what I was talking about. And I go back to what I said with this doctor. In my experience, this is what I've seen. This is what I've witnessed. This is what I've observed. And I thought that may be helpful to some of you as caregivers when dealing with your physicians and the medical providers treating your loved one or in general with anyone. Here's what I've witnessed. Here's what I've seen. Because your experience is unimpeachable. It's yours. You've experienced this. Your eyewitness is unimpeachable. This is what you saw. This is what you have encountered. And if you stay in that place, you're not going to get off into the weirdness of opinion. And I also think about that with our Christian faith. How many of us give our opinion versus, here's my experience. That's why I love going back to some of these hymns who have said it so beautifully, O God, our help in ages past. our hope for years to come, our shelter from the stormy blast and our eternal home. Well, that's saying, look, here's our experience. This is what we've seen, what he's done. You know, look at 1 Samuel 7, 12. Then Samuel took a stone and set it up between Mitzvah and Shem and called its name Ebenezer. For he said, thus far the Lord has helped us. And the word Ebenezer means stone of help. Do you know the only hymn that uses the word Ebenezer? It's from Come Thou Fount of Every Blessing. Here I raise my Ebenezer, hither by thy help I come, and I hope by thy good pleasure safely to arrive at home. Come Thou Fount of Every Blessing. It's such a great hymn. Sadly, the writer of that hymn, struggled with his faith. Even though he had that great line, bind my wandering heart to thee, prone to wonder, Lord, I feel it. And he struggled, I think, all of his life, or certainly later on in his life, and struggled with his faith. But at that time, he wrote that. Again, sometimes some of the best things can come from people who are struggling mightily with stuff. like Kurt Cobain or like the author of this hymn. His name was Robert Robertson. He wrote that hymn back in 1758. He was just a kid. He was just 22. Kurt Cobain was 27 when he killed himself. And I don't know if Robert Robertson ever... was able to resolve some of those issues in his life that he struggled with as he grew older, and he supposedly left the faith. I don't know. I have no idea. Somebody who knows more about him can maybe let me know. But he wrote this hymn, and it was a powerful hymn, and it's been sung all over the world. Here I raise my Ebenezer. Hither by thy help I've come. So far, thus far, the Lord has. This is my experience. You know, look at Revelation. They overcame by the blood of the Lamb and the word of their opinion. No, that's not what it says. It says they overcame by the blood of the Lamb and the word of their testimony, their experience. When I listen to preachers, one of the things I listen for is their experience. I'm not interested in really your opinion. Show me what the text says. Show me how you've seen this in your life or in others, what you've observed. And anchor me in this text. I'm not interested in your opinion that much. What I am interested in is understanding Scripture on an experiential level, to see these things fleshed out. And so when I talked to that surgeon, I said, look, in my experience, this is what I've watched with Gracie. I've seen this. I am testifying to this. And that was enough for this surgeon to use that in a protocol because it's firsthand experiential. That's the thing about our faith. We're not asked to take a leap of faith into the dark. We're invited by Scripture, asked, commanded by, to anchor our faith in the light. And this is the experience. I look at John, the Apostle John, when he's talking about Jesus being crucified. He said, I've witnessed this. Look at John 1935. He who saw it has borne witness. His testimony is true. And he knows that he is telling the truth that you may also believe. It's almost like John, and I don't know, if you're a theologian or scholar, you could tell me, but it's almost like he is saying this as an affidavit in court. Like, do you swear to tell the truth, the whole truth, and nothing but the truth? And he's saying, if you go back and look at the message, sometimes it helps me to understand it if you go back and look at different translations and paraphrases. In the message, it says, "...the eyewitness to these things has presented an accurate report. He saw it himself and is telling the truth so that you also will believe." I gave a firsthand account of credible witness to my wife's medical journey. The surgeon acted on that and made some changes in this. The Apostle John, the prophet Samuel, gave credible witness to what God has done. John gave witness to that. This is what happened to Jesus on the cross so that we will also believe. That's not stepping into the dark. That's acting on the light. And that is hope for the caregiver. This is Peter Rosenberger, PeterRosenberger.com. We'll be right back. Peter Rosenberger. He's not a preacher, but he's got great hair. Welcome back to Hope for the Caregiver. I am Peter Rosenberg. Glad to be with you today. And you know what? You may have just turned this show on midstream. You might be right here in the middle of the show. And you've been up all night having a conversation with the ceiling fan. And you wake up and you hear a program that's for family caregivers of all things. And you think, where has such a program been? Well, it's been right here. But I'm glad you're here with us now. And I've been doing this for 14 years. I've been on American Family Radio now for seven years. And I understand how difficult this journey is. I really do. And I understand what brings me comfort. And I ask you, think about that for just a moment. Most of you know my story. And if you're brand new to the audience and you're just coming in halfway through the show, that's okay. Four decades later. And on Monday or Tuesday, my wife will have her 93rd surgery. Car wreck back in 1983. Now think through the lengthy amount of time this is. How many hospitalizations? We've been here for this particular stretch for 10 weeks. Doesn't show, I don't know when we're going home. But we can't go home until this is done. And I understand how difficult this journey is. So what brings me comfort? What brings Gracie comfort in this? Is it anesthesia? Is it painkillers? Well, it helps ease her pain. But is that what brings her comfort? Is that what brings me comfort? What brings me comfort? I mean, think about it. I mean, I'm working out of a hotel room across the street in not the best part of town in Aurora, Colorado. I'd like to be at home. I could have been out on the snowmobile. and enjoying a beautiful Montana winter. Instead, I'm over here in a hotel, and sometimes I know the other night I had ramen noodle soup. I was tired. I didn't feel like going anywhere, so I just had ramen soup. I remember I was staying at a hotel down the road here. There's several hotels across the street, but now I've camped out at this one. I've been here now multiple times. We've been out here, and this is where I'm going to be permanently, but I don't think we're going to have to come back for another stretch. But I was staying at one down the road, and they got it messed up. This was some years ago. And they got it messed up in our room. But I was in the middle of Gracie's surgery, and I didn't do anything about it until about a week or two after she'd kind of stabilized. And I was checking out one. I mean, I was at the counter, and they had a little, you know how hotels do, they have a little place where you can buy overpriced items. And they had some soup. And I just, you know, it goes back to my college days, some ramen soup. And I had there on the counter my dinner that night because I was tired and I didn't feel like going anywhere. And I paid overpriced ramen soup, you know, and you know how much that stuff costs. But I mentioned the night manager. I said, look, I'm just now getting back with you. But when we got here, they were supposed to have this kind of room for my wife. They didn't have it. They really kind of messed it up and it was very difficult. And I just want to bring that to your attention. And she saw my soup on the counter there and she said, oh, I'm so sorry. Here, take that on us. It's the least we could do. And I used a great deal of restraint. You have no idea the torque involved in this. And I almost said, but I didn't say, it's ramen soup. There ain't no leaster. Of course, it's the least you could do. But she was very sincere, and I let it slide. Eventually, I talked to the daytime manager, and they worked out the problem and got it all squared away. So, you know, this is the way I'm living here. And Gracie's not certainly enjoying where she is. I mean, she's had now, this will be her sixth surgery in this 10-week stretch here. This leg just doesn't want to heal. And they have to go in there and redo something even different now. And so here we are. But we can't leave. This is for all the marbles. If we get this right, she has a better quality of life. If we get it wrong, she's in pretty dire circumstances for the rest of her life on earth. And so I get the journey. What brings me comfort? What has settled my heart down? What has given me the ability to focus and be clear-headed during this? And that is thinking on the things of God. Not abstractly. I'm talking about up close and personal, really contemplating these things. I've been studying. I've been going through the book of John while I'm here. And I am resolved to these things because I know that there's a greater work going on. And that I go back to what I've been saying over the last couple of weeks here with the Heidelberg Catechism. What is my only comfort in life and in death? And that is I belong to Christ. And in this world, he will see fit to allow us to go through very painful things, sometimes horrific things. I don't know why. I'm not really all that excited about it. I don't like it. But I am so committed to this because I see that he has saved me from something far worse. And I belong in his service. And that this is where he's asked us to go. And this is what Gracie said when I was praying for her. I mentioned this two weeks ago before her 91st surgery. And I was like, Lord, this is too many. Gracie said, no, it's not. This is how many he thinks is necessary. And we're going to do what he has led us to do. And I know that, I think it was Karl Marx or Stalin or somebody, one of those guys, who said that religion is the opioid for the masses, right? I can't say that I disagree with that. But I'm not talking about religion. I'm talking about theology. Understanding and knowing, discovering, learning about God. Religion is man's attempt to do these things. Theology is studying what God has already shown us in His Word. That we can know Him. And I've said this before on this program, but I had a caller call in to the Wednesday live show that I do and asked, is suffering required in order to grow in our Christianity? And my answer was, suffering is required to be a human being. In this world, we're going to have it. I mean, it's part of the condition. And you can live your whole life without being afflicted by trauma or disease of any magnitude, not even approaching anywhere near where Gracie is. But you're still going to die. Your body's going to get old and die. Unless Christ returns, none of us are getting out of this thing alive. That's just part of the human condition. It's how we trust God in those things. That's where the difference is. And I go back to this surgical event that we're dealing with here in our life right now. Now, these surgeons that I've been working with here, and they're wonderful men. I've worked with them now for some time, and I've gotten to know them a little bit, but I don't know them all that well. I don't know, for example, her attending surgeons, wife and kids and all those kinds of things. I really don't know a lot of his background. I know where he's from, but that's pretty much about it. But this man, who I barely know, will take my wife into a room with a bunch of strangers who I do not know, and they will do ghastly things to her body with ghastly tools that I wouldn't want to even touch. And then when he comes out, I'll thank him. And Gracie does too. She took his hand one time. Thank you. How often do we do that to people who wear white lab coats or surgical scrubs? Thank you, doctor. Thank you, doctor. And we treat them with reverence and respect, and we barely know them. We don't know where their doctrinal stances are. We don't know what they believe, why they believe it. We don't know those things. We just know that they've been certified to do such and such by the governing authorities of the state and the medical licensing board, and this hospital has vetted them, and the teaching university they went to has properly instructed them. And we take that on faith, even though we've never looked at their transcripts. we've never looked at their grades we don't know anything about them but we will let them go in there and do things to our loved ones and we will thank them for it how much more can we approach the king of kings and lord of lords when he does these things how much more skilled is he and we can know him he has made it possible that's what theology is he's laid it all out this is who i am Now, we will never know Him absolutely because we're not infinite beings like He is. But we can know Him truly. He's immutable. His loving kindness never fails. His grace, His mercy, His wisdom, His justice, His wrath, all of those things laid out. Corrie Ten Boone once said, don't be afraid to trust an unknown future to a known God. What brings us comfort is that I am not trusting Gracie to a bunch of people in medical gear that I don't know. I'm trusting her to the one I do know. You're going to hear me do this probably for the rest of the time I have a program. But I love to quote my father. And mom told me this story about him one time. And I've seen this in his life. And I have so many great, wonderful memories of things that he has said and imparted to us. But she was struggling with something young into their marriage. And I don't know how young it was, mom. Mom listens every week. I don't know how young you were, but it was some time ago. And she kind of popped off. How do you know that? because dad was sharing something from scripture with her she said well how do you know this and dad responded very calmly because i know god because i know god what gives me comfort i know god he's told me who he is and i take him at his word And that's what strengthens me. That's what equips me. That's what settles me down. I can produce a lengthy line of people, some of them in this audience, who have known me for a very long time and would say, yeah, that ain't Peter. That's evidence of the redemptive work of Christ in Peter's life because that ain't him. We know Peter. We've seen his work. And that's not me. And thanks be to God, it isn't me. It doesn't have to be you either. We don't have to be reactive all the time. We are invited by Scripture to cast all our cares on Him. We're invited to walk in His statutes, to trust Him, to take Him in His Word. And He gives us all the evidence that we need of said step of faith. And like I said in the last block, we're not stepping by faith into the dark. We're stepping by faith into the light. The credible testimony of others who have observed this, who have walked this, like John himself said in the Gospel of John, I saw it. I was there. Like I said to that surgeon, here's what I've seen. And so when I look at people like my father and like so many who said, here's what I have observed. Here's what I know. Here's what I've experienced. That is what comforts and strengthens me and equips me and fortifies me. And then I could take that into Gracie's hospital room and offer her the same comfort that I myself have received from the God of all comfort. And you know what that is? That is hope for this caregiver. This is Peter Rosenberger. We'll be right back. Welcome back to Hope for the Caregiver. This is Peter Rosenberger. Do you know what that hymn is? That hymn is called Abide With Me. And it's from my CD, Songs for the Caregiver. I've always loved this hymn. This is my mother's favorite hymn. And I've played this countless times. You can see this, like I said, on my CD, Psalms for the Caregiver. You can download the whole thing wherever digital music is streamed, or you can call Logos Bookstore in Nashville, Tennessee and get a copy of it. They're the only ones that care. It's all out at my website, PeterRosenberger.com, but that's not the purpose of me telling you all this. I used to play this hymn and many others in the sanctuary church where we attended in Nashville for many years and My pastor at the time asked me to play on Sunday mornings as people were coming in to help create a more reverent atmosphere for the church. So people would just talk, you know, yabber. They would come in and be more reflective. So I would work out a lot of these hymn arrangements that I did there. And during the week, I would practice this. And I noticed that I wasn't alone in the sanctuary. And at the back, there was a custodian there at the church And he would be putting hymnals back in the racks and sweeping and straightening it up, very much like my father used to do when he was a young man. And I've got a picture of my father when he was working at a church as a custodian. So I had a very special place in my heart for custodians of churches, and this man was no exception. And I would stop and ask him, I'd say, hey, do you want me to play something for you? And he said, no, just keep playing, just keep playing. So I'd play and sometimes I'd practice there for an hour, maybe more. And a beautiful Steinway up at the front of the church. And that's the cover of my CD is me playing in that sanctuary by myself. Except I have one picture of me playing there. It was taken from the choir loft area where I was. And you can make out Mike in the very back there. And that picture hangs on a wall in my parents' home. I gave that to my father and That picture is juxtaposed against the picture of my dad when he was in the sanctuary serving. Now, why am I telling you all this? Well, this week in the news, they released more of the writings from the shooter at the Covenant School there in Nashville. The first victim that she shot and killed was Mike, the custodian who used to listen to me play the piano. Two years ago this week, I went back to Nashville to play at his funeral And I played for him one last time. I look at the horrific things about that event, and it's still surreal. It's hard to believe. Hard to believe it happened. And the unspeakable tragedy with so many. I refuse, and if this gets me in trouble, you can write letters to peter at the internet dot Google. But I refuse to call this individual a transgender or a guy. was a girl it was a woman 28 years old i believe who was very very very disturbed according to the news reports she had been writing horrifically violent plans for some time and i don't know why it wasn't caught i don't know why nobody seemed to intercept this or say something, but I just know that from the facts, she showed up that day, and Mike was the first person in her path, and she shot and killed him. And I think about all the times that Mike said to me, just keep playing, just keep playing. So I do, and I played at his funeral two years ago this week, and I played, the opening hymn was Great Is Our Faithfulness, And I got to tell you all, I laid into it. I didn't hold back. I didn't play it like a mourner. Mike wouldn't have wanted me to. Play it with conviction. Play it like a believer. And he would want me to do so. I said, this time I was in the front of the church in the choir loft area, different sanctuary. But Mike's casket was just, instead of him being at the back of the church sitting there listening, His casket was right there up front, just 10, 15 feet away from me. And these are hard things. We don't have the words for it. We groan. But we're not alone in our groaning. And I just want to leave you with today. I know this is a bit of a somber note for the show, but I wanted to leave this with because I never forget that the reason why people listen to this program is because they're hurting. And the reason why people give me an hour of their time to listen to this is because they feel like they're drowning. And I understand that sometimes the person who understands you the most is the one who's bled like you have. And I have. Still do. Many times in that sanctuary when I was playing, I was pouring out my heart because I didn't have the words for some of the things that Gracie and I were going through. Mike kept saying, just keep playing. Just keep playing. Just keep playing. The Spirit groans on our behalf. Scripture tells us to pray without ceasing. Just keep praying. Just keep praying. when we don't have the words. And that's why I'm grateful for music. I wish I had the caregiver keyboard here at this hotel while we're in this hospital visit, but I don't. So I have to make do. I look forward to being able to getting home and playing the piano some more. Just keep playing. It's a hard thing to read about that in the news. And this is the world we're in. And it's not going to get any better anytime soon. It doesn't look like. But we are not absolved from walking into that craziness and heartache with the confidence of the gospel. And that is what I am committed to doing. I've been writing a song when the shooting occurred. I've been writing a song that had it for about a month or two, but it wasn't finished. I finished it right after the shooting. In fact, I finished it within that evening because I was just so overwhelmed by watching this. And I had Gracie sing it. I titled the piece Covenant Lament. I really didn't know what else to call it. What else can you say? He's just lamenting. And I went to the words of Scripture that helped shape this. This is all Scripture. And I wanted to leave this with you all today. At the end of this program, some of you are groaning. Some of you are weeping. And I want you to know that there's one who weeps for us and groans for us. And we can trust him. Listen to Gracie sing as we take the show out today. And thank you for your time. I'm Peter Rosenberger. And I remember what my friend Mike told me. Keep playing. Just keep playing.

Moira Gleason, Daily Signal journalism intern.

James Moore grew up in Arklow, County Wicklow and was in a boxing gym from 6 years of age. His amateur career was in his own words a “late developer” in fact he never won an Irish title at schoolboy, youth or junior level in the early days. It wasn't long until he would start to have great success beginning with an Irish Intermediate title in 1997. The goal was always to win that National Elite title, but standing in his way was the seasoned, Neil Gough. After coming up short in semi-finals and finals to the Waterford man, he would eventually claim that senior title in 2001 beating Gough in the final. James would soon add a Four Nations gold medal before representing Ireland at the 2001 World Senior championships in Belfast.Those championships would prove to be the greatest week of James' amateur career. He would go on to claim the only bronze medal from a strong Irish team. James talks about what he had to overcome having 5 fights in 6 days to win his medal. He also talks about sparring stories with Carl Frochin the training camp and nights out with David Haye. After this success at these championships, he would find the next year or so a struggle with injuries, constant training camps and the tragedy of losing 3 of his best friends in a caraccident. James would still continue to have success in 2002-2003 winning 2 more Irish Elite titles and multiple Four Nation gold medals, but when an Olympic place wasn't secured in 2004, he knew that professional boxing was thenext step in his career.James would move to New York and train in the famous Gleason's Gym and quickly build up an undefeated record over the next 3 years. He would add a New York State title and top the bill at Madison Square Garden, Theatre. He would build a 15-0 undefeated record before losing a dubious decision to Gabriel Rosado in 2008. He would go on to win 2 more fights before losing a points decision to future World Champion, Yuri Foreman for the NABF title and Pawel Wolak in his final fight at Yankee Stadium. Since retirement, James has become a part owner in a successful bar in Queens, NY and is happy and content in the States with his wife and 3 kids. He is a humble man who very rarely talks about his boxing story, so I am really excited to release this to you all.

Readings: Joshua 5:9-12 | 2 Corinthians 5:16-21 | Luke 15:1-3, 11b-32 | Psalm 32. Preached for the Fourth Sunday in Lent (2025-03-29).

Robert Gleason var farsæll húðflúrari á sínum yngri árum en það var ekki starfsferill sem hann átti eftir að fylgja út lífið.  Á einhverjum tímapunkti tók Robert ákvarðanir sem áttu eftir að umturna lífi hans töluvert. Og að lokum koma honum innan veggja fangelsis.  Það átti þó ekki eftir að halda honum frá afbrotum og kom hann til með að fremja hin alvarlegustu brot innan veggja fangelsis.    Þátturinn er í boði Define the Line Sport Kóðinn "morðskúrinn" veitir 15% afslátt inn á  www.definethelinesport.com   Komdu í áskrift!  www.pardus.is/mordskurinn   

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes "Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer" by Felix Y. Feng, et al published January 31, 2025. Come back for the next episode where JCO Precision Oncology Conversations host, Dr. Rafeh Naqash interviews the author of the JCO PO article discussed, Dr. Tim Showalter. TRANSCRIPT Natalie DelRocco: Hello and welcome to JCO Precision Oncology Article Insights. I'm your host Natalie Del Rocco. Today, we'll be discussing the article, “Digital Pathology-Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer.” We will also be discussing the accompanying editorial, “Leveraging Artificial Intelligence to Improve Risk Stratification in Nonmetastatic Castration-Resistant Prostate Cancer.” So, we're going to start by summarizing the original report and then we'll jump into a few of the high-level interpretations that were supplied by the editorial.   The original report by Feng et. al. describes the application of multimodal artificial intelligence to data collected on a nonmetastatic castration-resistant prostate cancer. We will call this disease moving forward NMCRPC, a Clinical Trial. So, we're looking at data from an NMCRPC clinical trial. The SPARTAN trial was a randomized phase three trial and this study compared metastasis-free survival as the primary endpoint for those treated with traditional androgen deprivation therapy or ADT to those treated with androgen deprivation therapy plus apalutamide. Other secondary endpoints included progression-free survival and overall survival, but the primary endpoint there was metastasis-free survival or MFS. This study found that the addition of apalutamide resulted in a significantly longer median metastasis-free survival compared to androgen deprivation therapy alone. And we should note that this is a double-blind placebo-controlled trial. In the overall study, 1,207 patients participated and over the course of this study histopathology slides were collected and they were digitized for future use. And that future use is what we are going to be discussing today.  The authors do note that there are currently no good biomarkers for use in NMCRPC. The authors seem to be inspired by the ArteraAI prostate test, which was a recent application of multimodal artificial intelligence models. But in localized prostate cancer as opposed to NMCRPC, the authors constructed a multimodal artificial intelligence model or an MMAI model. They applied this to the SPARTAN trial with the intention of developing a risk score that could be used for risk stratification in NMCRPC. And we should note here that multimodal artificial intelligence or MMAI is a broad class of artificial intelligence models, and they can analyze different types of data at one time, hence the term multimodal. So in this example, the author's primary data source of interest were those digitized histopathology images because histopathology tells you a lot about NMCRPC. The authors though also wanted their model to consider traditional clinical factors that are known to be prognostic such as Gleason score, tumor stage, PSA level, and age. So those two different types of data, those histopathology images and that traditional clinical data are the two different types of data that make this model multimodal. So we should note here importantly, after dropping missing data, 420 patients contribute to this model, the MMAI model.  The authors generate a risk score from this MMAI model and they categorize that risk score into low, intermediate, and high risk groups using clinical knowledge. The authors found in their results that an increase in this MMAI risk score was associated with an increased hazard of metastasis-free survival event with a hazard ratio from a Cox proportional hazards model of 1.72. To summarize how the authors arrived here, they derived a risk score from this MMAI model which incorporates both imaging and regular data. They plugged this risk score into a Cox proportional hazards mode,l modeling metastasis-free survival and they found that an increase in that MMAI based risk score is associated with increased hazard of metastasis-free event with a hazard ratio of 1.72, which is quite large. Additionally, the risk score seemed to be associated with PFS2 and OS, which were two of the secondary endpoints from the SPARTAN clinical trial, though the effect sizes were more modest. Those are the highlights from the original report, the methods and the results.  The accompanying editorial notes that both histopathology and Gleason score specifically are very critical to understanding prostate cancer, and Gleason score alone is not sufficient to summarize the complexity of the disease, although it is a well validated prognostic factor for prostate cancer. So this makes MMAI an excellent tool in the setting described by the authors. We have an existing prognostic factor that doesn't describe the entire picture of the disease by itself and so we can use those digitized histopathology slides to help bolster our understanding and provide the model more information. MMAI allows you to do this because it can take in different types of data. So that was the main conclusion of the editorial.  They also summarize a number of recent validations of MMAI models in prostate cancer research, noting that it will be an important tool for risk stratification and has already been shown to outperform classical techniques. The editorial though does highlight a number of weaknesses of this paper, limitations and I think the most important one to highlight, and we touched on this earlier, is that 420 patients from the SPARTAN clinical trial contributed to the development of this MMAI score. That is a small proportion of the roughly 1200 patients that did participate in the SPARTAN clinical trial. So we have a small subgroup analysis that can be limiting and this model will need to be validated in a broader population in the future.   Thank you for listening to JCO Precision Oncology Article Insights. Don't forget to give us a rating or a review and be sure to subscribe so that you never miss an episode. You can find all ASCO shows at asco.org/podcasts.    The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.      

What does a fulfilling life really look like?In this episode, we sit down with Don Gleason—veteran, corporate leader, and now purpose-driven coach—to explore what it truly means to live a life that energises you rather than drains you.We unpack the pressures that lead people to stay in unfulfilling careers, the mental and emotional toll it can take, and why self-awareness is the key to change.From understanding your values and personality to making courageous choices that align with your deeper goals, this conversation offers both insight and encouragement for anyone feeling stuck, restless, or ready for more.Don also shares practical tools, like the DISC personality assessment and the “wheel of life” framework, to help you start designing a life that actually works for you—not just on paper, but in your heart, mind, and day-to-day.Whether you're rethinking your career, craving better balance, or simply asking bigger questions about how you want to live, this episode invites you to pause, reflect, and realign.Don Gleason is a Career Progression and Transition Coach, Speaker, Trainer, K.E.Y. Mentor, and Veteran who helps professionals obtain the career position and life they truly want.Drawing on 42 years of experience in military and corporate leadership, Don now focuses on guiding others to uncover their strengths, align their passions, and move confidently toward fulfilling work and purposeful living.He discovered his own path early—first through a mission to “Clean America's Waters,” then by leading teams to new heights.Today, Don supports others through career transitions by helping them gain clarity on who they are, what energizes them, and how to turn that insight into meaningful action.He believes many people know the destination they desire—but not the path to get there.Freebie: Master the Art of Targeted Resumes - https://achieve-new-heights-llc.kit.com/9862a7ebe2Website: www.AchieveNewHeights.comLinkedIn: https://www.linkedin.com/in/don-gleason

Former AMC Commissioner Martha Gleason is on a mission to blow the lid off of the waste and abuse she says is happening at the Anastasia Mosquito Control Board. by 904 Now

Readings: Genesis 15:1-12,17-18 | Philippians 3:17-4:1 | Luke 13:31-35 | Psalm 27. Preached for the 2nd Sunday in Lent (2025-03-16).

Did President Biden refuse to allow Elon Musk to help rescue two stranded astronauts in space because he feared the bad optics? Glenn exposes Biden's pattern of deserting his own people due to politics. President Trump's latest message to Hamas is a clear distinction from the Biden administration: We will not leave our people behind, and justice will be swift to anybody who harms Americans. Glenn explains why the cowboy way of life is making a comeback in America. Professional Bull Riders CEO and commissioner Sean Gleason joins to discuss why heartland values are being embraced and resonating with more Americans than ever before.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Did President Biden refuse to allow Elon Musk to help rescue two stranded astronauts in space because he feared the bad optics? Glenn exposes Biden's pattern of deserting his own people due to politics. President Trump's latest message to Hamas is a clear distinction from the Biden administration: We will not leave our people behind, and justice will be swift to anybody who harms Americans. The Supreme Court has ruled against the Trump administration, forcing President Trump to release $2 billion of USAID funding. Glenn breaks down the ruling and explains why he believes the justices got it wrong. We need the next SCOTUS justice to be the next Justice Scalia. Is Trump's newest executive order the first step to dismantling the Department of Education? Glenn explains why the cowboy way of life is making a comeback in America. Glenn and Stu discuss the accusation that Stacey Abrams received over a billion in taxpayer dollars to form a committee. Professional Bull Riders CEO and commissioner Sean Gleason joins to discuss why heartland values are being embraced and resonating with more Americans than ever before. Glenn previews his newest podcast with Kid Rock.  Learn more about your ad choices. Visit megaphone.fm/adchoices

We are thrilled this week to bring you the Season 1 Episode 4 recap and analysis 00:00:14 for the Last of Us TV Show as well as an amazing interview with Dr. Jennifer Gleason 00:44:10. Dr. Gleason is a professor teaching philosophy and biomedical ethics at the University of Alabama and walks us through the foundations of the field and how to view characters and their decisions in The Last of Us through various ethical lenses. Enjoy!

Your hosts sit down with Tania Gleason, an athlete on the University of Nebraska-Omaha women's track & field team. Tania shares about her breakthrough season, including her past month of PRs, what it will take to make a Summit League final in a deeply contested sprints field, and which of her teammates to watch come conference weekend. Ryan & Cam also discuss this past week's Summit League Peak Performers and preview both the UNO women's program.

Readings: Genesis 45:3-11, 15 | 1 Corinthians 15:35-38,42-50 | Luke 6:27-38 | Psalm 37:1-12, 41-42. Preached for the Seventh Sunday after the Epiphany (2025-02-23).

On today's Program: Mark Alford, U.S. Representative for Missouri's 4th district, reacts to the latest developments on Ukraine and Russia and comments on JD Vance's speech in Munich. Chris Mitchell, Middle East Bureau Chief for CBN News, shares the

In this episode, Dr. Geo welcomes Dr. Jonathan Haas, Director of Radiation Oncology at NYU Grossman School of Medicine in Long Island, to discuss the latest advancements in stereotactic body radiation therapy (SBRT) for prostate cancer. Dr. Haas, a pioneer in CyberKnife radiation, shares the latest research, treatment options, and what's on the horizon for prostate cancer care.Episode Highlights:✔ SBRT & CyberKnife Technology – How high-dose, highly targeted radiation is replacing traditional 9-week radiation therapy.✔ New Developments – Research is underway to reduce SBRT treatment from five sessions to just two, making therapy even more convenient.✔ Prostate Motion & Radiation Accuracy – The prostate moves during treatment—learn how advanced imaging and AI-powered tracking compensate for movement to improve precision.✔ Androgen Deprivation Therapy (ADT) & SBRT – Not all patients may need ADT. New studies explore whether men with Gleason 4+3 can avoid hormone therapy.✔ Who is a Candidate? – Understanding the differences between Gleason 6, 7, 8, and 9 patients and who may benefit most from SBRT.✔ Side Effects & Risk Factors – Discussing common side effects like bladder bleeding (2%), rectal irritation (5%), erectile dysfunction (25% over 5 years), and strictures (2%).✔ Artificial Intelligence & Radiation Therapy – The RayStation AI system is now optimizing radiation planning, increasing precision, and making treatments more effective.✔ Choosing the Right Treatment Center – Why it's crucial to seek multidisciplinary care, get second opinions, and explore clinical trials for the best possible outcome.Takeaway: The landscape of prostate cancer treatment is evolving rapidly. If you or a loved one is considering radiation therapy, ask about SBRT, AI-driven imaging, and new clinical trials to ensure you receive the most advanced and effective care.Join Dr. Geo each week for expert insights, science-backed advice, and empowering conversations designed to help you live better with age. ----------------Thank you to our partnersThe ProLon 5-Day Fasting Mimicking Diet is a plant-based meal program designed to provide fasting benefits while allowing food intake. Developed by Dr. Valter Longo, it supports cellular renewal, fat loss, and metabolic health through low-calorie, pre-packaged meals that maintain the body in a fasting state.Special Offer: Thank you for listening, you can purchase the ProLon kit for just $148 by using this link.We'd also like to thank our partner AG1 by Athletic Greens. AG1 contains 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens to help you start your day right. This special blend of ingredients supports your gut health, nervous system, immune system, energy, recovery, focus, and aging. All the essentials in one scoop. Enjoy AG1 by Athletic Greens.----------------Thanks for listening to this week's episode. Subscribe to The Dr. Geo YouTube...

ay Santos, Sub-Commander. Gleason, Sub-Commander Hepcat and Major Elvis Newton sing in a musical tribute. Image by Chris KempSign up for a Backstage Pass and enjoy a 30,000 plus hour archive, Phil's new podcast, Classic podcasts, Bobbie Dooley's podcasts, special live streaming events and shows, and oh so very much more…

TVC 676.2: From September 2011: Phil Gries plays a clip from Jackie Gleason's interview with Bobby Darin on the Mar. 17, 1961 edition of Jackie Gleason, the short-lived prime talk show (CBS, 1961) that was borne out of necessity following the demise of You're in The Picture, the infamous game show hosted by The Great One that CBS canceled after its premiere broadcast on Jan. 20, 1961. This segment also includes audio from Darin's appearance on Stage Show (CBS, 1954-1956), a music variety series produced by Gleason. Darin's appearance on Stage Show marked his first national TV appearance. Audio courtesy ATVAudio.com.

TVC 676.1: An encore presentation of an edition from The Sounds of Lost Television that originally aired in September 2011 in which Phil Gries plays audio highlights from Jackie Gleason, the short-lived CBS prime talk show that The Great One hosted for two months in early 1961, and a show that was borne out of necessity following the demise of You're in The Picture, the infamous game show hosted by Gleason, which CBS canceled after its one and only broadcast on Jan. 20, 1961. This segment includes a clip from the famous on-air “apology” for You're in the Picture (telecast Jan. 27, 1961), in which Gleason spent thirty minutes denouncing Picture as “the biggest bomb” in TV history, plus clips from Gleason's subsequent interviews with Art Carney (telecast Feb. 17, 1961) and Gordon MacRae and Sheila MacRae (telecast Feb. 24, 1961). Audio courtesy ATVAudio.com.

It's true: we talk too much. And we know that just one more brilliant lecture from us will not solve our boys' every problem—but we can't seem to help ourselves. This week on HeightsCast, lower school head Colin Gleason takes an intentional look at how we as parents and educators engage our boys, and how we might do better. The conversation reminds us that parenting is relational, not a delivery system, and that ultimately we want to keep the lines of communication open. Chapters: 2:30 Talk less, engage more 8:31 Over-supervision leads to acting, not being 15:11 Strategies for listening 17:23 Recon: trying to draw something out 21:12 Showing unanxious interest 25:38 Response: when they come to you 28:13 Keep them coming to you 31:01 Let the emotions breathe 37:32 Disrespect and complaints 43:38 The impact of listening Featured opportunities: Parents' Conference: Freedom and Addiction at The Heights School (April 12, 2025) link coming soon Teaching Men's Conference at The Heights School (October 2025) link coming soon Also on the Forum: On Emotional Presence and Imperfect Parenting featuring Alvaro de Vicente Seeing Our Boys with Loving Eyes: Not Projects but Persons featuring Tom Royals Building a Relationship of Trust with Your Son featuring Alvaro de Vicente

Melinda Meador is an attorney with a passion for history. The Gleason, Tennessee native has served as felony prosecutor for the Obion County office of the 27th Judicial District Attorney; as a judicial clerk, assistant district attorney and criminal defense lawyer on the Texas Court of Appeals; and in several leadership positions at the FDIC's headquarters Washington D.C. Today she is in private practice with the firm of Lowe, Yeager & Brown PLLC. Meador's family was among the original settlers of Weakley County, and she lives on a farm that has been in her family for 195 years. In this episode, Meador provides details from “Strange Fruit: The Forgotten Lynchings of Northwest Tennessee and Southwestern Kentucky, 1869-1931,” the thesis for her 2021 master's in American history from Murray State University. This episode is sponsored by Jerry Ward Autoplex.