Podcasts about aging biology

Host: Andrew Wilner, MD, Author of "The Locum Life: A Physician's Guide to Locum Tenens" Guest: Jini Naidoo, PhD According to new research featured in Aging Biology, a treatment involving 4-phenylubrate (PBA) may delay or reverse signs of Alzheimer's disease. To learn more, Dr. Andrew Wilner dives into the results and potential implications of this mouse-model study with Dr. Jini Naidoo, Research Associate Professor of Sleep Medicine at the Perelman School of Medicine at the University of Pennsylvania.

30 Years of Aging Biology: A Pioneer's Perspective (Cynthia Kenyon - VP Aging Biology, Calico Labs)Dr. Cynthia Kenyon reflects on the evolution of the longevity field over the 30 years since the publication of her groundbreaking paper, “A C. elegans mutant that lives twice as long as wild type,” a genetic analysis of one of the first single-gene mutations to extend lifespan in the worm. She recounts the initial excitement and skepticism around the idea of a pathway that regulates aging, and subsequent validation of this and related ideas in a wide range of model organisms. She also discusses her longstanding belief in the translational potential to improve human healthspan, and her experience as a co-founder of one of the first longevity biotech startups, Elixir Pharmaceuticals, in 1999. Based on her unique historical perspective—and with undiminished enthusiasm—she looks ahead to the unsolved mysteries that will propel the next generation of breakthroughs.Key ideas:Origins of looking at aging regulation in C. elegans in the 1990sage-1 and daf-2 as the first aging genesEarly resistance to the idea of studying aging at the molecular levelCloning of genes to reveal conserved longevity pathways (IIS/mTOR)Extending lifespan in invertebrates, and then miceThe connection between stress resistance to evolutionary theoryDr. Kenyon's initial belief in the translatability of aging scienceCo-founding Elixir Pharmaceuticals in 1999 to target agingCurrent optimism about interventions against agingNeed for public funding of large trials of natural compoundsExcitement about newest mechanisms like reprogrammingThe enduring promise of targeting core nutrient-sensing networksDevelopmental origins of aging rates and resilienceLinks: Email questions, comments, and feedback to podcast@bioagelabs.comTranslating Aging on Twitter: @bioagepodcastBioAge Labs Website bioagelabs.comBioAge Labs Twitter @bioagelabsBioAge Labs LinkedIn

In this episode of Translating Aging, host Chris Patil is joined by Dr. Courtney Hudson-Paz, the Founder and Program Director of the Time Initiative, an organization whose mission is to build a network of undergraduate leaders in aging biology.Courtney takes us on a journey into the world of aging biology and the mission of the Time Initiative, highlighting how this groundbreaking organization is cultivating the next generation of leaders. She shares her insights into the importance of early engagement in scientific research, the challenges faced by longevity research, and the transformative potential of geroscience. In addition, Courtney explains how the core component of the Time Initiative's program, the Time Fellowship, offers a unique opportunity for talented individuals to engage in impactful research, community-building, and mentorship. She notes the pressing need to address age-related diseases and describes the Time Initiative's efforts to create a diverse and inclusive ecosystem in aging biology. She also celebrates the fact that the contributions of ambitious young minds in the field have the potential to accelerate scientific progress and significantly reshape the field of aging biology.In this podcast, you will learn about the mission and impact of the Time Initiative and discover the strategic importance of early engagement in scientific research and the transformative potential of geroscience. You will also gain insights into the Time Fellowship, as well as the importance of building a diverse and inclusive ecosystem in aging biology, and the role it plays in shaping the future of the field.OutlineThe Time Initiative's mission to inspire and cultivate future leaders in aging biology by supporting undergraduatesThe need to expand the talent pool and workforce to drive progress in aging researchThe potential of geroscience and rejuvenation biotech to transform human health and societyCollaborative efforts with the American Federation for Aging Research (AFAR) Events, resources, and opportunities available through The Time Initiative to educate students about aging researchThe Time Fellowship program: Open to all disciplines All-expenses paid annual retreat Community group and mentorship opportunities$8,000 grants for summer projectsComparing The Time Initiative to similar organizations also focused on community building in longevity scienceAdvice and resources for students interested in aging research and geroscienceA vision for The Time Initiative's growth and future impact on the fieldQuotes:“Our motivation is really the same motivation of the field, right? We all see that the world is aging rapidly, we already have a billion people suffering from age related diseases.”"By focusing on undergrads, we're really investing in the future of the field... nurturing the next generation of leaders, innovators, and researchers."“I think what makes it unique is the focus on really early stage talent, and going after people that aren't already interested in aging, as well.”“The idea of the geroscience hypothesis is so compelling, that I feel like just the exposure is enough.”“I want to firmly establish it as a key driving force in the field of aging. I want to grow our networks of fellows, our mentors and our partners. I envision a future where our fellows are empowered by this experience through our program and they become influential figures in the field.”"The opportunities and possibility of the impact we can have in people's lives...is worth that extra funding and really deserves extra attention.""I want them conducting cutting-edge research and pioneering innovative treatments.""Stay curious. Be bold. Ask the questions, look for answers.

Today Debbie tackles the topic of aging (better? longer??) with Andrew Steele, an ebullient British scientist, writer and author of Ageless: The New Science of Getting Older Without Getting Old.After earning a PhD in physics from Oxford, Andrew decided that aging -  not cancer or other diseases - was the single most important scientific challenge of our time. Why? Because of the suffering that goes along with old age.So he switched fields to biogerontology, the study of the processes of aging at the cellular level.Andrew, 37, doesn't advocate for immortality. As he puts it: “It's not about extending lifespan, but rather healthspan." His interest, he maintains, is in helping humans stay healthier longer. Debbie asks Andrew what the most important biological aging processes are. He responds with a clear explanation of cell biology as it relates to aging: from senescent cells and cellular exhaustion to your epigenetic age, and more.And he explains that some of these genes and processes can be manipulated to slow or possibly reverse aging - at least, so far, in worms and mice.Andrew is exuberant and makes everything understandable.They talk about:The 10 hallmarks of the aging processSpecifically, how research on worms and mice translates to humansWhy 65 - 70 could be the ideal age to take an anti-aging pill (no, it doesn't exist yet)They also discuss:Dietary restriction (a topic of aging research since the 1950s)Why the mega-wealthy are so interested in biohacking to improve health and extend lifeMoral and ethical implications of humans living much longerThis is an important conversation and we hope you will find it as thought provoking as we did.   Mentioned in this episode or useful:BioYouTube channelHow science can reverse aging - and why we'd want to (video)TwitterInstagramAndrew's book and bonus chapterAgeless: The New Science of Getting Older Without Getting Old by Andrew Steele (Doubleday, 2021)Bonus chapter: The ethics of ageing biology by Andrew SteeleVideo from bonus chapter: Would curing aging destroy the planet?Articles and referencesBiogerontologyLooking Forward to Your 170th Birthday by Annie Murphy Paul (New York Times Book Review, April 2, 2021)Why Anti-Aging Science is so Alluring by Daniela J. Lamas (New York Times, Jan. 4, 2023)The Hallmarks of Aging by Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer (Pubmed, June 6, 2013)Viral Tweet about Blueprint & Bryan JohnsonCAR T Cells: Engineering Immune Cells to Treat Cancer (National Cancer Institute) Get the inside skinny on every episode of [B]OLDER:Subscribe to Debbie's newsletter for the inside story about every episode. You will also get her 34-page writing guide: https://bitly.com/debbie-free-guide. Request from Debbie:If you've been enjoying the podcast, please take a moment to leave a short review on Apple Podcasts. It really makes a difference in attracting new listeners.  Connect with Debbie:debbieweil.com[B]OLDER podcastEmail: thebolderpodcast@gmail.comBlog: Gap Year After SixtyFacebook: @debbieweilInstagram: @debbieweilLinkedIn: linkedin.com/in/debbieweilTwitter: @debbieweil Our Media Partners:CoGenerate (formerly Encore.org)MEA and with thanks to Chip ConleyNext For Me (former media partner and in memory of Jeff Tidwell) How to Support this podcast:Leave a review on Apple PodcastsSubscribe via Apple Podcasts, Google Podcasts, Stitcher or Spotify Credits:Host: Debbie WeilProducer: Far Out MediaMusic: Lakeside Path by Duck Lake

Dr. Ana Maria Cuervo, M.D., Ph.D. (https://www.einsteinmed.edu/faculty/8784/ana-maria-cuervo/) is Co-Director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. She serves as a Professor in the Department of Developmental & Molecular Biology, and the Department of Medicine (Hepatology), and has the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases. Dr. Cuervo studied medicine and pursued a Ph.D. in biochemistry and molecular biology at the University of Valencia, as well as post-doctoral work at Tufts, and in 2001 she started her laboratory at Einstein, where she studies the role of protein-degradation in aging and age-related disorders, with emphasis in neurodegeneration and metabolic disorders. Dr. Cuervo's group is interested in understanding how altered proteins can be eliminated from cells and their components recycled. Her group has linked alterations in lysosomal protein degradation (autophagy) with different neurodegenerative diseases including Parkinson's, Alzheimer's and Huntington's disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible. Her lab has also pioneered studies demonstrating a tight link between autophagy and cellular metabolism. They described how autophagy coordinates glucose and lipid metabolism and how failure of different autophagic pathways with age contribute to important metabolic disorders such as diabetes or obesity. Dr. Cuervo is considered a leader in the field of protein degradation in relation to biology of aging and has been invited to present her work in numerous national and international institutions, including name lectures as the Robert R. Konh Memorial Lecture, the NIH Director's, the Roy Walford, the Feodor Lynen, the Margaret Pittman, the IUBMB Award, the David H. Murdock, the Gerry Aurbach, the SEBBM L'Oreal-UNESCO for Women in Science, the C. Ronald Kahn Distinguished Lecture and the Harvey Society Lecture. She has organized and chaired international conferences on protein degradation and on aging, belongs to the editorial board of scientific journals in this topic, and is currently co-editor-in-chief of Aging Cell. Dr. Cuervo has served in NIH advisory panels, special emphasis panels, and study sections, the NIA Scientific Council and the NIH Council of Councils and has been recently elected member of the NIA Board of Scientific Counselors and member of the of the Advisory Committee to the NIH Deputy Director. She has received numerous awards for the pioneering work of her team such as the 2005 P. Benson Award in Cell Biology, the 2005/8 Keith Porter Fellow in Cell Biology, the 2006 Nathan Shock Memorial Lecture Award, the 2008 Vincent Cristofalo Rising Start in Aging Award, the 2010 Bennett J. Cohen Award in Aging Biology, the 2012 Marshall S. Horwitz, MD Faculty Prize for Research Excellence and the 2015 Saul Korey Prize in Translational Medicine Science. She has also received twice the LaDonne Schulman Teaching Award. In 2015 she was elected International Academic of the Royal Academy of Medicine of the Valencia Community and in 2017, she was elected member of the Real Academia de Ciencias Exactas, Fisicas y Naturales. She was elected member of the American Academy of Arts and Sciences in 2018 and member of the National Academy of Science in 2019.

BRN AM |  Aging insights from reptiles and amphibians |  Dr. Manuel Moro, Division of Aging Biology at the National Institute on Aging | Visit www.broadcastretirementnetwork.com

What a pleasure and honor to have world-renowned cultural psychoneuroimmunologist Dr. Mario Martinez on the show today. I've had both of his ground-breaking books, The Mind Body Code and The Mind Body Self in my library since college when my acute fascination with the mind-body connection really kicked in so I was thrilled to be able to sit down with Dr. Martinez and learn from a true pioneer in the industry and founder of Biocognition, or what he calls, the mindbodyculture. Dr. Martinez is a licensed clinical psychologist who argues that current mechanical models of the life sciences study disease by reducing the body to pathological parts. He proposes that the healing process must include the cultural history that contextualizes the mind-body expression of health, and challenges the cultural beliefs that perpetuate genetic helplessness. Biocognitive theory integrates research in psychoneuroimmunology, neuroscience, and cultural anthropology to conceptualize and address the causes of health, the learning of illness, and the biocultural ingredients of longevity. EPISODE TIME STAMPS 00:01:34 Dr. Martinez's Specialties: Neuropsychology And Psychoimmunology 00:02:43 The Phoenix Self, Dr. Martinez's Upcoming Book 00:05:02 Descarte And The History Of Mind-Body Separation Misconception 00:11:45 The Value Of Accepting Compliments 00:15:27 Defining “Biocognition” 00:16:43 Why Culture Devalues The Individual 00:18:41 Aging According To Modern Culture 00:21:12 Why The Term “Deterioration” Is Used In Gerontology 00:24:14 What Is Epigenetics? 00:26:51 Do Centenarians See The Doctor? 00:27:50 How Culture Affects Our Health 00:31:55 How Your Beliefs Affect Your Aging Process 00:36:09 See Episode 69. The Power Of Words For Manifesting Magic And Casting Spells With Metaphysical Mother Goose, Laurel Airica 00:36:33 Victimhood 00:40:28 The Perils Of Joy 00:41:32 The Power Of Positive Thinking 00:42:50 How Love Becomes Need 00:46:05 The Rituals That Lead To Long Life 00:49:43 Avoiding The Survivor's Identity 00:50:42 How We Create Our Identity 00:53:15 How To Bring Your Hologram To The Present 00:56:05 Archetypal Wounds 01:02:31 Biology And Gender Dysphoria 01:07:11 Ignorance Of Typical Psychosexual Processing In Adolescence 01:10:41 The Dark Side Of Social Constructionism 01:11:24 Aristotle's “Eudaimonia” 01:14:43 How To Find Dr. Martinez DR. MARTINEZ RESOURCES Website Facebook YouTube LinkedIn Project: The Epigenetic Self (Longevity Center in Warsaw, Poland) Books: The MindBody Code, The MindBody Self, The Man from Autumn TO CONTACT AMY FOURNIER: WEBSITE: http://amyfournier.com/ EMAIL: amy@amyfournier.com INSTAGRAM: @FitAmyTV YOUTUBE: Awakening Aphrodite Podcast/FitAmyTV FACEBOOK: Amy Fournier *NEW: Join my FREE ONLINE WOMEN'S CIRCLE GROUP!

What a pleasure and honor to have world-renowned cultural psychoneuroimmunologist Dr. Mario Martinez on the show today. I've had both of his ground-breaking books, The Mind Body Code and The Mind Body Self in my library since college when my acute fascination with the mind-body connection really kicked in so I was thrilled to be able to sit down with Dr. Martinez and learn from a true pioneer in the industry and founder of Biocognition, or what he calls, the mindbodyculture. Dr. Martinez is a licensed clinical psychologist who argues that current mechanical models of the life sciences study disease by reducing the body to pathological parts. He proposes that the healing process must include the cultural history that contextualizes the mind-body expression of health, and challenges the cultural beliefs that perpetuate genetic helplessness. Biocognitive theory integrates research in psychoneuroimmunology, neuroscience, and cultural anthropology to conceptualize and address the causes of health, the learning of illness, and the biocultural ingredients of longevity. EPISODE TIME STAMPS 00:01:34 Dr. Martinez's Specialties: Neuropsychology And Psychoimmunology 00:02:43 The Phoenix Self, Dr. Martinez's Upcoming Book 00:05:02 Descarte And The History Of Mind-Body Separation Misconception 00:11:45 The Value Of Accepting Compliments 00:15:27 Defining “Biocognition” 00:16:43 Why Culture Devalues The Individual 00:18:41 Aging According To Modern Culture 00:21:12 Why The Term “Deterioration” Is Used In Gerontology 00:24:14 What Is Epigenetics? 00:26:51 Do Centenarians See The Doctor? 00:27:50 How Culture Affects Our Health 00:31:55 How Your Beliefs Affect Your Aging Process 00:36:09 See Episode 69. The Power Of Words For Manifesting Magic And Casting Spells With Metaphysical Mother Goose, Laurel Airica 00:36:33 Victimhood 00:40:28 The Perils Of Joy 00:41:32 The Power Of Positive Thinking 00:42:50 How Love Becomes Need 00:46:05 The Rituals That Lead To Long Life 00:49:43 Avoiding The Survivor's Identity 00:50:42 How We Create Our Identity 00:53:15 How To Bring Your Hologram To The Present 00:56:05 Archetypal Wounds 01:02:31 Biology And Gender Dysphoria 01:07:11 Ignorance Of Typical Psychosexual Processing In Adolescence 01:10:41 The Dark Side Of Social Constructionism 01:11:24 Aristotle's “Eudaimonia” 01:14:43 How To Find Dr. Martinez DR. MARTINEZ RESOURCES Website Facebook YouTube LinkedIn Project: The Epigenetic Self (Longevity Center in Warsaw, Poland) Books: The MindBody Code, The MindBody Self, The Man from Autumn TO CONTACT AMY FOURNIER: WEBSITE: http://amyfournier.com/ EMAIL: amy@amyfournier.com INSTAGRAM: @FitAmyTV YOUTUBE: Awakening Aphrodite Podcast/FitAmyTV FACEBOOK: Amy Fournier *NEW: Join my FREE ONLINE WOMEN'S CIRCLE GROUP!

What a pleasure and honor to have world-renowned cultural psychoneuroimmunologist Dr. Mario Martinez on the show today. I've had both of his ground-breaking books, The Mind Body Code and The Mind Body Self in my library since college when my acute fascination with the mind-body connection really kicked in so I was thrilled to be able to sit down with Dr. Martinez and learn from a true pioneer in the industry and founder of Biocognition, or what he calls, the mindbodyculture. Dr. Martinez is a licensed clinical psychologist who argues that current mechanical models of the life sciences study disease by reducing the body to pathological parts. He proposes that the healing process must include the cultural history that contextualizes the mind-body expression of health, and challenges the cultural beliefs that perpetuate genetic helplessness. Biocognitive theory integrates research in psychoneuroimmunology, neuroscience, and cultural anthropology to conceptualize and address the causes of health, the learning of illness, and the biocultural ingredients of longevity. EPISODE TIME STAMPS 00:01:34 Dr. Martinez's Specialties: Neuropsychology And Psychoimmunology 00:02:43 The Phoenix Self, Dr. Martinez's Upcoming Book 00:05:02 Descarte And The History Of Mind-Body Separation Misconception 00:11:45 The Value Of Accepting Compliments 00:15:27 Defining “Biocognition” 00:16:43 Why Culture Devalues The Individual 00:18:41 Aging According To Modern Culture 00:21:12 Why The Term “Deterioration” Is Used In Gerontology 00:24:14 What Is Epigenetics? 00:26:51 Do Centenarians See The Doctor? 00:27:50 How Culture Affects Our Health 00:31:55 How Your Beliefs Affect Your Aging Process 00:36:09 See Episode 69. The Power Of Words For Manifesting Magic And Casting Spells With Metaphysical Mother Goose, Laurel Airica 00:36:33 Victimhood 00:40:28 The Perils Of Joy 00:41:32 The Power Of Positive Thinking 00:42:50 How Love Becomes Need 00:46:05 The Rituals That Lead To Long Life 00:49:43 Avoiding The Survivor's Identity 00:50:42 How We Create Our Identity 00:53:15 How To Bring Your Hologram To The Present 00:56:05 Archetypal Wounds 01:02:31 Biology And Gender Dysphoria 01:07:11 Ignorance Of Typical Psychosexual Processing In Adolescence 01:10:41 The Dark Side Of Social Constructionism 01:11:24 Aristotle's “Eudaimonia” 01:14:43 How To Find Dr. Martinez DR. MARTINEZ RESOURCES Website Facebook YouTube LinkedIn Project: The Epigenetic Self (Longevity Center in Warsaw, Poland) Books: The MindBody Code, The MindBody Self, The Man from Autumn TO CONTACT AMY FOURNIER: WEBSITE: http://amyfournier.com/ EMAIL: amy@amyfournier.com INSTAGRAM: @FitAmyTV YOUTUBE: Awakening Aphrodite Podcast/FitAmyTV FACEBOOK: Amy Fournier *NEW: Join my FREE ONLINE WOMEN'S CIRCLE GROUP!

Dr. Felipe Sierra is an internationally known research leader and advocate in the field of geroscience. He is also the former director of the National Institute on Aging's Division of Aging Biology. Alliance for Aging Research President and CEO Sue Peschin talks with Dr. Sierra about geroscience and the upcoming Euro-Geroscience conference, which he is chairing. Learn more about the conference, taking place March 24-25, 2022 in Toulouse, France: http://www.euro-geroscience.com.

La Dra. Ana María Cuervo es codirectora del Instituto Einstein para la Investigación del Envejecimiento y miembro del Centro de Investigación del Hígado y del Centro de Cáncer Einstein. En 2001 comenzó su laboratorio en Einstein, donde estudia el papel de la degradación de proteínas en el envejecimiento y los trastornos relacionados con la edad, con énfasis en la neurodegeneración y los trastornos metabólicos. El grupo de la Dra. Cuervo está interesado en comprender cómo se pueden eliminar las proteínas alteradas de las células y reciclar sus componentes. Su grupo ha relacionado las alteraciones en la degradación de proteínas lisosomales (autofagia) con diferentes enfermedades neurodegenerativas, incluidas la enfermedad de Parkinson, Alzheimer y Huntington. También han demostrado que la restauración de la función lisosomal normal previene la acumulación de proteínas dañadas con la edad, demostrando así que es posible la eliminación de estos productos tóxicos. Su laboratorio también ha sido pionero en estudios que demuestran un estrecho vínculo entre la autofagia y el metabolismo celular. Describieron cómo la autofagia coordina el metabolismo de la glucosa y los lípidos y cómo la falla de diferentes vías autofágicas con la edad contribuye a importantes trastornos metabólicos como la diabetes o la obesidad. La Dra. Cuervo es considerada una líder en el campo de la degradación de proteínas en relación con la biología del envejecimiento y ha sido invitada a presentar su trabajo en numerosas instituciones nacionales e internacionales, incluidas conferencias de nombre como la Conferencia Conmemorativa de Robert R. Konh, la Directora de los NIH, el Roy Walford, el Feodor Lynen, el Margaret Pittman, el Premio IUBMB, el David H. Murdoxk, el Gerry Aurbach, el SEBBM L'Oreal-UNESCO for Women in Science, el C. Ronald Kahn Distinguished Lecture y el Harvey Society Lecture . Ha organizado y presidido conferencias internacionales sobre degradación de proteínas y envejecimiento, pertenece al consejo editorial de revistas científicas en este tema y actualmente es coeditora en jefe de Aging Cell. La Dra. Cuervo ha trabajado en paneles asesores de NIH, paneles de énfasis especial y secciones de estudio, el Consejo Científico de la NIA y el Consejo de Consejos de NIH y ha sido recientemente elegida miembra de la Junta de Consejeros Científicos de la NIA y miembro del Comité Asesor para la Directora Adjunta de los NIH. Ha recibido numerosos premios por el trabajo pionero de su equipo, como el Premio P. Benson 2005 en Biología Celular, el Keith Porter Fellow en Biología Celular 2005/8, el Premio de la Conferencia en Memoria de Nathan Shock 2006, el 2008 Vincent Cristofalo Rising Start in Aging Award, el 2010 Bennett J. Cohen Award in Aging Biology, el 2012 Marshall S. Horwitz, MD Faculty Prize for Research Excellence y el 2015 Saul Korey Prize in Translational Medicine Science. También ha recibido dos veces el Premio de Enseñanza LaDonne Schulman. En 2015 fue elegida Académica Internacional de la Real Academia de Medicina de la Comunidad Valenciana y en 2017, miembro de la Real Academia de Ciencias Exactas, Fisicas y Naturales. Fue elegida miembro de la Academia Estadounidense de Artes y Ciencias en 2018 y miembro de la Academia Nacional de Ciencias en 2019.

Dr. Ron Kohanski, Director, Division of Aging Biology, discuss the work of the National Institute of Aging, some of their key projects, why he followed his career path and his interest in woodworking. https://www.nia.nih.gov/

Longevity scientist Matt Kaeberlein, PhD, discusses how reversing your biologic age can dramatically reduce your risk of getting sick from respiratory viruses. ➢Today's show is brought to you by Keto Brick! One of the best Ketogenic meal replacements out there: https://www.ketobrick.com In today's show, Matt explains how targeting the known mechanisms of aging improves immune health and reduces the risk of many common diseases known to shorten a person’s life span. Research and Show Notes: https://bit.ly/3hX9kAz

The NIEHS Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on understanding the health effects of exposures when there is a lag between exposure and the onset of the disease. In the second session, presenters will discuss new methods to better understand potential disease risk by identifying key characteristics or hallmarks of chemicals and disease. This research may provide insight into identifying chemicals that may lead to disease earlier on in the disease progression and help explore how aging itself can be a risk factor for disease. Martyn Smith, Ph.D., director of the University of California, Berkeley SRP Center, will describe the key characteristics approach to helping identify chemicals that cause cancer and other adverse outcomes. In evaluating whether a chemical can cause cancer or another adverse outcome, three lines of evidence are typically considered: epidemiology, animal bioassays, and mechanistic evidence. The key characteristics (KC) form the basis of a uniform approach for searching, organizing, and evaluating mechanistic evidence to support hazard identification without the need for a deductive hypothesis. KCs are the established properties of the chemicals and have been developed for carcinogens, endocrine disruptors, reproductive and neuro-toxicants, and are becoming increasingly used by authoritative bodies and regulatory agencies. Michelle La Merrill, Ph.D., associate professor at the University of California, Davis, will focus on using the key characteristics of endocrine disruptors to organize mechanistic support of the developmental basis of endocrine disruption. Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing health risks, such as for cancer, reproductive impairment, cognitive deficits, and obesity. Inspired by work to improve hazard identification of carcinogens using KCs, they have developed 10 KCs of EDCs based on our knowledge of hormone actions and EDC effects. This presentation will reveal how these 10 KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs that contribute to developmental vulnerability to adult disease, and use DDT and bisphenol A as examples to illustrate this approach. Ron Kohanski, Ph.D., deputy director of the Division of Aging Biology at the National Institute on Aging, will focus on aging as a risk factor for disease. Geroscience is a recently evolved field of research on the intersection between the biology of aging and the biology of disease. The geroscience hypothesis states that "slowing the rate of aging will delay the onset and decrease the severity of chronic diseases and comorbidities that primarily impact older people." This does not mean that old age per se is a risk factor, any more than claiming that childhood is a risk factor for diseases that primarily afflict children. However, in the latter case the underlying causes may be the stage of development does not yet confer resilience against pathogens, for example. In the former case, the underlying causes may be loss of that resilience (acquired over a lifetime) from the failure of underlying molecular networks that maintain the body and adapt to environmental changes. This talk will present a viewpoint that aging can be treated as a risk factor, attempting to show that both the magnitude and duration of changes that are the process of aging can be altered in ways that are either beneficial or detrimental to health. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRPExposures2_052820/

The NIEHS Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on understanding the health effects of exposures when there is a lag between exposure and the onset of the disease. In the second session, presenters will discuss new methods to better understand potential disease risk by identifying key characteristics or hallmarks of chemicals and disease. This research may provide insight into identifying chemicals that may lead to disease earlier on in the disease progression and help explore how aging itself can be a risk factor for disease. Martyn Smith, Ph.D., director of the University of California, Berkeley SRP Center, will describe the key characteristics approach to helping identify chemicals that cause cancer and other adverse outcomes. In evaluating whether a chemical can cause cancer or another adverse outcome, three lines of evidence are typically considered: epidemiology, animal bioassays, and mechanistic evidence. The key characteristics (KC) form the basis of a uniform approach for searching, organizing, and evaluating mechanistic evidence to support hazard identification without the need for a deductive hypothesis. KCs are the established properties of the chemicals and have been developed for carcinogens, endocrine disruptors, reproductive and neuro-toxicants, and are becoming increasingly used by authoritative bodies and regulatory agencies. Michelle La Merrill, Ph.D., associate professor at the University of California, Davis, will focus on using the key characteristics of endocrine disruptors to organize mechanistic support of the developmental basis of endocrine disruption. Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing health risks, such as for cancer, reproductive impairment, cognitive deficits, and obesity. Inspired by work to improve hazard identification of carcinogens using KCs, they have developed 10 KCs of EDCs based on our knowledge of hormone actions and EDC effects. This presentation will reveal how these 10 KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs that contribute to developmental vulnerability to adult disease, and use DDT and bisphenol A as examples to illustrate this approach. Ron Kohanski, Ph.D., deputy director of the Division of Aging Biology at the National Institute on Aging, will focus on aging as a risk factor for disease. Geroscience is a recently evolved field of research on the intersection between the biology of aging and the biology of disease. The geroscience hypothesis states that "slowing the rate of aging will delay the onset and decrease the severity of chronic diseases and comorbidities that primarily impact older people." This does not mean that old age per se is a risk factor, any more than claiming that childhood is a risk factor for diseases that primarily afflict children. However, in the latter case the underlying causes may be the stage of development does not yet confer resilience against pathogens, for example. In the former case, the underlying causes may be loss of that resilience (acquired over a lifetime) from the failure of underlying molecular networks that maintain the body and adapt to environmental changes. This talk will present a viewpoint that aging can be treated as a risk factor, attempting to show that both the magnitude and duration of changes that are the process of aging can be altered in ways that are either beneficial or detrimental to health. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRPExposures2_052820/

Aging -- everybody does it, very few people actually do something about it. Coleen Murphy is an exception. In her laboratory at Princeton, she and her team study aging in the famous C. Elegans roundworm, with an eye to extending its lifespan as well as figuring out exactly what processes take place when we age. In this episode we contemplate what scientists have learned about aging, and the prospects for ameliorating its effects -- or curing it altogether? -- even in human beings. Coleen Murphy received her Ph.D. in biochemistry from Stanford University, and is currently Professor in the Department of Molecular Biology and the Lewis-Sigler Institute of Integrative Genomics at Princeton. Home page at the Lewis-Sigler Institute Lab web page Princeton Profile Google Scholar publication page Twitter

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]