Podcasts about biogerontology

In this episode host Nils Behrens is joined by Aubrey de Grey, one of the world's leading biogerontologists, for a thought-provoking discussion on aging and the possibility of combating age-related diseases. De Grey shares his belief that aging can be treated as a disease—one that can be managed and potentially reversed. The conversation dives deep into the mechanics of aging, exploring: The seven signs of aging and how they guide medical advancements. Technological innovations like CRISPR and their potential to revolutionize aging research. The growing acceptance of anti-aging science in the scientific community. Ethical and societal challenges in the quest to extend human lifespan. De Grey offers his compelling vision of a future where people live healthy, vibrant lives, free from the burdens of aging. Key Takeaways: Aging is not an inevitable disease. The human body can be repaired like a machine. Advancements in technology are paving the way for breakthroughs in aging research. A future without age-related diseases is within reach. Tune in to this fascinating conversation and learn how modern science is shaping a healthier, longer future for us all. More about the episode at www.sunday.de/podcast About Sunday Natural Sunday Natural was born out of a deep passion and extensive research in the fields of health, healing, and personal growth. The initial motivation for founding Sunday Natural in 2013 was the lack of natural, high-quality products available on the market. Since then, the Berlin-based premium nutrition brand has remained committed to its guiding principle – creating products that follow the example of nature, are absolutely pure and free from any additives, and stand out for their exceptional quality. Today, Sunday Natural is one of the most renowned quality manufacturers in Germany, with its own research and development department in Berlin. Learn more at https://www.sunday.de.

Less than two weeks ago, the world's oldest person died. The Spanish woman Maria Branyas Morera lived until the extraordinary age of 117. She put her longevity down to “order, tranquillity, good connection with family and friends”, among other things. But, some scientists argue that taking longevity advice from centenarians is actually a fool's errand. Joining Seán to discuss this is Richard Faragher, Professor of Biogerontology at the University of Brighton.

Less than two weeks ago, the world's oldest person died. The Spanish woman Maria Branyas Morera lived until the extraordinary age of 117. She put her longevity down to “order, tranquillity, good connection with family and friends”, among other things. But, some scientists argue that taking longevity advice from centenarians is actually a fool's errand. Joining Seán to discuss this is Richard Faragher, Professor of Biogerontology at the University of Brighton.

Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours This week on the podcast Mikki speaks to returning guest Dr Darren Candow about the updates in the creatine research over the last two years. They talk about dosing creatine for different effects (performance versus cognition), where the research lies with respect to healthy aging, the best time to take creatine and what to take it with, sex differences in creatine usage, and more.Dr. Darren Candow, PhD, CSEP-CEP, is a Full Professor and Associate Dean-Graduate Studies and Research in the Faculty of Kinesiology & Health Studies, University of Regina. Dr. Candow supervises the Aging Muscle and Bone Health Laboratory and serves on the editorial review board for the Journal of Aging and Physical Activity, Journal of the International Society of Sports Nutrition, and Biogerontology. Dr. Candow has received over $1.5 million in research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, and the Nutricia Research Foundation and has published over 100 journal and knowledge dissemination articles involving exercise and nutrition. Dr. Candow also serves as the Chief Scientific Officer for TDF Sports. https://www.uregina.ca/kinesiology/faculty-staff/faculty/candow-darren.htmlDarren episode 71 https://podcast.mikkiwilliden.com/71  Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

EPISODE SUMMARY Join scientist and mindset & high-performance coach Claudia Garbutt and accomplished aging researcher José Pedro Castro, PhD, as they discuss aging and health In this episode, we talk about: - What is aging & age-related inflammation - Good inflammation VS bad inflammation - Aging clocks and important biomarkers     Episode NOTES José Pedro Castro completed his PhD in Biomedicine in 2015 by Universidade do Porto Faculdade de Medicina. He then moved to the German Institute of Human Nutrition and joined the Grune Lab (Berlin, Germany) to study how age-related redox and metabolism changes impact the adipose tissue and skeletal muscle.  After completing his aims, he was awarded with the prestigious DFG Max-Kade fellowship and moved to Harvard Medical School (Boston, USA) where he joined the Gladyshev Lab. There, he explored the genetics of aging, age-related diseases and lifespan control from a systems biology perspective.  Recently, and after returning to Portugal, he has joined Logarinho Lab at I3S (Porto, Portugal) after being awarded with the FCT CEEC 5th Edition for Assistant Researcher. Published over 30 articles in peer-reviewed journals such as Cell, Nature Aging or Science Advances. Has received several awards and/or honors, including Early Research Career Award (2010) and Young Investigator Award (2013). He is a reviewer for several scientific journals and a review editor for Redox Biology and Frontiers in Aging. His focus lies on understanding the biology of aging and age-related diseases. Using a combination of experimental and computational approaches he is keen to unravel age-related molecular trajectories leading to chronic diseases.  He is also an assistant professor for Immunology and an invited professor for Biogerontology and Aging and Nutrition. He is involved in several dissemination activities such as the creation of the Portuguese Society for Science and Medicine of Longevity.  On a more personal note, José also dedicates his time to literature by reading as much as he can and writing short fiction stories, but his true desire is to one day write a full novel!   Links: https://www.linkedin.com/in/jos%C3%A9-pedro-castro-phd-92528620   ------------ Click this link to listen on your favorite podcast player and if you enjoy the show, please leave a rating & review: https://linktr.ee/wiredforsuccess   Help me keep this show running and awesome: Hit subscribe and join the tribe! THANK YOU for your support! 

How long can we live? How much of aging is genetics vs. environment? How old are your cells? What can we learn from the world's oldest people? World-renowned aging expert and biogerontologist Dr. Caleb "Tuck" Finch takes a quick break from his prolific research at USC to answer Alie's sometimes basic questions about everything from molecules to Blue Zones.A donation was made to Cure Alzheimer's FundFull-length (*not* G-rated) Biogerontology episode + tons of science linksMore kid-friendly Smologies episodes!Become a patron of Ologies for as little as a buck a monthOlogiesMerch.com has hats, shirts, masks, totes!Follow @Ologies on Twitter and InstagramFollow @AlieWard on Twitter and InstagramSound editing by Steven Ray Morris, Mercedes Maitland of Maitland Audio, and Jarrett Sleeper of MindJam MediaMade possible by work from Noel Dilworth, Susan Hale, Kelly R. Dwyer, Emily White, & Erin TalbertSmologies theme song by Harold Malcolm

Today Debbie tackles the topic of aging (better? longer??) with Andrew Steele, an ebullient British scientist, writer and author of Ageless: The New Science of Getting Older Without Getting Old.After earning a PhD in physics from Oxford, Andrew decided that aging -  not cancer or other diseases - was the single most important scientific challenge of our time. Why? Because of the suffering that goes along with old age.So he switched fields to biogerontology, the study of the processes of aging at the cellular level.Andrew, 37, doesn't advocate for immortality. As he puts it: “It's not about extending lifespan, but rather healthspan." His interest, he maintains, is in helping humans stay healthier longer. Debbie asks Andrew what the most important biological aging processes are. He responds with a clear explanation of cell biology as it relates to aging: from senescent cells and cellular exhaustion to your epigenetic age, and more.And he explains that some of these genes and processes can be manipulated to slow or possibly reverse aging - at least, so far, in worms and mice.Andrew is exuberant and makes everything understandable.They talk about:The 10 hallmarks of the aging processSpecifically, how research on worms and mice translates to humansWhy 65 - 70 could be the ideal age to take an anti-aging pill (no, it doesn't exist yet)They also discuss:Dietary restriction (a topic of aging research since the 1950s)Why the mega-wealthy are so interested in biohacking to improve health and extend lifeMoral and ethical implications of humans living much longerThis is an important conversation and we hope you will find it as thought provoking as we did.   Mentioned in this episode or useful:BioYouTube channelHow science can reverse aging - and why we'd want to (video)TwitterInstagramAndrew's book and bonus chapterAgeless: The New Science of Getting Older Without Getting Old by Andrew Steele (Doubleday, 2021)Bonus chapter: The ethics of ageing biology by Andrew SteeleVideo from bonus chapter: Would curing aging destroy the planet?Articles and referencesBiogerontologyLooking Forward to Your 170th Birthday by Annie Murphy Paul (New York Times Book Review, April 2, 2021)Why Anti-Aging Science is so Alluring by Daniela J. Lamas (New York Times, Jan. 4, 2023)The Hallmarks of Aging by Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer (Pubmed, June 6, 2013)Viral Tweet about Blueprint & Bryan JohnsonCAR T Cells: Engineering Immune Cells to Treat Cancer (National Cancer Institute) Get the inside skinny on every episode of [B]OLDER:Subscribe to Debbie's newsletter for the inside story about every episode. You will also get her 34-page writing guide: https://bitly.com/debbie-free-guide. Request from Debbie:If you've been enjoying the podcast, please take a moment to leave a short review on Apple Podcasts. It really makes a difference in attracting new listeners.  Connect with Debbie:debbieweil.com[B]OLDER podcastEmail: thebolderpodcast@gmail.comBlog: Gap Year After SixtyFacebook: @debbieweilInstagram: @debbieweilLinkedIn: linkedin.com/in/debbieweilTwitter: @debbieweil Our Media Partners:CoGenerate (formerly Encore.org)MEA and with thanks to Chip ConleyNext For Me (former media partner and in memory of Jeff Tidwell) How to Support this podcast:Leave a review on Apple PodcastsSubscribe via Apple Podcasts, Google Podcasts, Stitcher or Spotify Credits:Host: Debbie WeilProducer: Far Out MediaMusic: Lakeside Path by Duck Lake

Join Caroline for Part 5 of our “What Is Aging?” series covering the digestive system, as well as bowel and bladder continence. We discuss common age related changes like nutrient absorption, digestive motility, constipation, and incontinence. We also talk about the role of physical therapy and health coaching in improving these systems with age.    Courses:  Modern Aging: Physiological Processes and Societal Responses   Related Episodes: Ep 32 Aging Bones and Joints Ep 33 Aging Muscles Ep 34 Aging Nervous System Ep 35 Aging Heart and Lungs Further Reading: Soenen, S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2016). The ageing gastrointestinal tract. Current opinion in clinical nutrition and metabolic care, 19(1), 12–18. https://doi.org/10.1097/MCO.0000000000000238 Ranson, R. N., & Saffrey, M. J. (2015). Neurogenic mechanisms in bladder and bowel ageing. Biogerontology, 16(2), 265–284. https://doi.org/10.1007/s10522-015-9554-3    Work with me  https://carolinemorris.com   

Dr. Darren Candow, PhD, CSEP-CEP, is a Full Professor and Associate Dean-Graduate Studies and Research in the Faculty of Kinesiology & Health Studies, University of Regina.  Dr. Candow supervises the Aging Muscle and Bone Health Laboratory and serves on the editorial review board for the Journal of Aging and Physical Activity, Journal of the International Society of Sports Nutrition, and Biogerontology.  Dr. Candow has received over $1.5 million in research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, and the Nutricia Research Foundation and has published over 100 journal and knowledge dissemination articles involving exercise and nutrition.  Dr. Candow also serves as the Chief Scientific Officer for TDF Sports.  In today's episode of Barbell Shrugged you will learn: Why creatine is so widely accepted supplement in the scientific community What happens when you digest creatine How creatine increases performance in the gym Why creatine does not cause you to hold on to water The three phases of creatine cycle How creatine affects muscle, brain, and bone tissue How creatine can help with traumatic brain injuries. How creatine can be used for children Creatine's affect on menstrual cycle How creatine improves bone mineral density To learn more, please go to https://rapidhealthreport.com Connect with our guests: Dr. Darren Candow on Instagram Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram Dan Garner on Instagram

Omega-3 fatty acid supplementation could help with cognitive depression Duke University, August 27 2022.    An article appearing in the Journal of the American College of Cardiology: Heart Failure reported the outcome of a pilot study that found an association between supplementation with the omega-3 fatty acids EPA and DHA and reduced cognitive depression in heart failure patients. Cognitive depression is characterized by subjective symptoms such as pessimism and sadness, while somatic depression includes physical manifestations that include fatigue and sleep disturbances. The study included 108 patients with a major depressive disorder, chronic heart failure and low blood levels of omega-3 fatty acids. Participants received fish oil containing EPA and DHA, a high EPA supplement or a placebo daily for 12 weeks. Blood samples collected before and after treatment were evaluated for red blood cell EPA and DHA, the Omega-3 Index and other factors. Omega-3 values increased in both the EPA/DHA and EPA only groups, while the placebo group showed little change. Higher omega-3 Index values were associated with lower cognitive depression scores. Social functioning as evaluated by a general health survey significantly improved with EPA/DHA supplementation and showed a tendency toward improvement in the high EPA group. "This was a study in already depressed individuals, which meant the researchers are looking to high-dose (although it could have been higher) omega-3 supplements to improve depressive symptoms, like a drug," noted coauthor William S. Harris, PhD. "Generally, we think of the function of omega-3s as preventative rather than as treatment. If used as treatment, the dose must be fairly high (4 grams is a typical 'drug' dose) and blood levels must be measured.”   Groundbreaking Study Shows Fasting Can Slow Aging, Rebuild Immune System University of Southern California, August 28, 2022 Cutting-edge research reveals that occasionally adopting a diet that mimics the effects of fasting may provide dramatic health benefits. “Fasting flips a regenerative switch essentially regenerating the entire immune system. It gives the OK for stem cells to go begin proliferating and rebuild the entire system,” said Prof Valter Longo, Professor of Gerontology and the Biological Sciences at the University of California. A study, led by USC's Dr. Valter, revealed that a “cycles of a four-day low-calorie diet that mimics fasting (FMD) cut visceral belly fat and elevated the number of progenitor and stem cells in several organs of old mice — including the brain, where it boosted neural regeneration and improved learning and memory,” according to USC News. Dr. Longo notes that strict fasting can be difficult for people to adhere to, and also has the potential to be dangerous, while pointing out that a fasting mimicking diet is much safer and easier. “Strict fasting is hard for people to stick to, and it can also be dangerous, so we developed a complex diet that triggers the same effects in the body,” said Longo, Edna M. Jones Professor of Biogerontology at the USC Davis School of Gerontology and director of the USC Longevity Institute. “I've personally tried both, and the fasting mimicking diet is a lot easier and also a lot safer.” The fasting mimicking diet cuts a person's daily caloric intake over the fasting period down to 34 to 54 percent of their daily average, with a specific balance of micronutrients, fats, carbohydrates, and proteins. In previous groundbreaking research, Longo has shown how fasting can protect immune and other cells from chemotherapy toxicity, while simultaneously starving out cancer cells. Fasting for seventy-two hours protected cancer patients against the toxic impact of chemotherapy: “The good news is the body got rid of the parts in the system which might be damaged or old and inefficient parts, during the fasting. If you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally, a new immune system,” he said. “It's about reprogramming the body so it enters a slower aging mode, but also rejuvenating it through stem cell-based regeneration,” Longo said. “It's not a typical diet because it isn't something you need to stay on.” “If the results remain as positive as the current ones, I believe this FMD will represent the first safe and effective intervention to promote positive changes associated with longevity and health span, which can be recommended by a physician,” Longo told USC News. “We will soon meet with FDA officers to pursue several FDA claims for disease prevention and treatment.”     “Micro-breaks” from tasks show promise in boosting wellbeing   West University of Timioara (Romania), August 31, 2022 A review of 22 previously published studies suggests that taking micro-breaks—discontinuing a task for periods of 10 minutes or less—is generally associated with reduced fatigue and increased vigor. Patricia Albulescu of the West University of Timioara, Romania, and colleagues present these findings in the open-access journal PLOS ONE . Concerns are rising over the heavy workloads and long shifts faced by many employees currently in the work force. An increasing number of studies explore various aspects of employee energy management and recovery, often focused on recovery after the workday is over. However, the potential effects of recovery processes during the workday remain unclear. To improve understanding, Albulescu and colleagues conducted a meta-analysis of 22 studies from 19 manuscripts published within the last 30 years, all of which examined the potential benefits of taking micro-breaks from assigned tasks. Tasks varied between experiments and included work simulations, real work-related tasks, and non-work-related cognitive tests. Types of breaks varied as well, including physical breaks, relaxing activities, and more engaging activities, such as watching videos. Statistical analysis of the combined study results revealed an overall association between micro-breaks, higher levels of vigor, and lower fatigue in participants, suggesting that micro-breaks may contribute to wellbeing. These findings support micro-breaks as a potential strategy for boosting wellbeing in the workplace. However, when it comes to job performance, longer breaks may be needed for recovery from more cognitively demanding tasks. Future research could investigate longer breaks as well as address other remaining questions, such as optimal activities to engage in during a micro-break.     Mindfulness training improves diabetes symptoms and blood sugar levels VA Healthcare System in Pittsburg, August 24, 2022 It's easy to let current circumstances in our lives dictate our thoughts and feelings. When a problem arises, if we get sick, we are quick to blame it on anything but ourselves. In this way, we are undermining the power of our own thoughts and intentions at work, in us and around us, guiding our present reality. Instead of letting negative circumstances and illness just happen to us, we should embrace the power of mindfulness, allowing ourselves to instead happen to the universe around us. The awareness of our bodily functions, our breathing, our thinking, our motives and the way we treat others helps us be mindful and aware, putting us in the driver seat of determining our paths through life. Research recently presented at the American Association of Diabetes Educators Annual Meeting & Exhibition showed that positive mindfulness training can help improve diabetes symptoms and blood sugar levels. The research was carried out on 28 veterans with type 1 and type 2 diabetes at the VA Healthcare System in Pittsburgh, Pennsylvania, as part of the Mindful Stress Reduction in Diabetes Education program (Mind-STRIDE). Diabetes-related stress falls significantly in veterans during mindfulness training and deep breathing meditation   Veterans' glucose levels drop dramatically as diabetes-related distress falls 41 percent The changes over the course of the training were significant. Three months after mindfulness training, diabetes-related distress for all 28 veterans fell 41 percent! A1C levels dropped significantly, almost measuring under the ideal 7.0 range. They went from 8.3 before the mindfulness training to 7.3 after the classes. On top of that, veterans completed diabetes self-management goals with more efficiency after the training. They were better problem solvers, began to eat healthier, were more active and coped better with stress.       An Oral Combination of Vitamins A, C, E, and Mg++ Improves hearing University of Castilla (Spain), August 28, 2022 According to news reporting originating in Albacete, Spain,research stated, "The increasing rate of age-related hearing loss (ARHL), with its subsequent reduction in quality of life and increase in health care costs, requires new therapeutic strategies to reduce and delay its impact. The goal of this study was to determine if ARHL could be reduced in a rat model by administering a combination of antioxidant vitamins A, C, and E acting as free radical scavengers along with Mg, a known powerful cochlear vasodilator (ACEMg)." The news reporters obtained a quote from the research from the University of Castilla, "Toward this goal, young adult, 3 month-old Wistar rats were divided into two groups: one was fed with a diet composed of regular chow ('normal diet,' ND); the other received a diet based on chow enriched in ACEMg ('enhanced diet,' ED). Auditory brainstem recordings (ABR) were performed at 0.5, 1, 2, 4, 8, 16, and 32 kHz at 3, 6-8, and 12-14 months of age. No differences were observed at 3 months of age, in both ND and ED animals. At 6-8 and 12-14 months of age there were significant increases in auditory thresholds and a reduction in the wave amplitudes at all frequencies tested, compatible with progressive development of ARHL. However, at 6-8 months threshold shifts in ED rats were significantly lower in low and medium frequencies, and wave amplitudes were significantly larger at all frequencies when compared to ND rats. In the oldest animals, differences in the threshold shift persisted, as well as in the amplitude of the wave II, suggesting a protective effect of ACEMg on auditory function during aging."   According to the news reporters, the research concluded: "These findings indicate that oral ACEMg may provide an effective adjuvant therapeutic intervention for the treatment of ARHL, delaying the progression of hearing impairment associated with age."       Scientists use 'sleep age' to infer long-term health Stanford University, September 1, 2022   Sleep age is a projected age that correlates to one's health based on their quality of sleep. So for instance, if you analyze the sleep characteristics of dozens of 55-year-olds and average them out, you'll have an idea of what sleep looks like at that age. For instance, someone who's 55 and sleeps soundly through the night with good quality REM cycles could, theoretically, might have a sleep age of 45. Sleep expert Emmanuel Mignot, MD, Ph.D., and his colleagues analyzed some 12,000 studies, each of which focused on an individual, that reported characteristics of their sleep—such as chin and leg movement, breathing and heartbeat. Their goal was to develop a system that assigns one's sleep age and, using machine learning, identifies the variations in sleep most closely linked to mortality. I spoke with Mignot, who has studied sleep for 30 years, about why sleep age is important, how it's calculated and what the study's findings imply about our health. Why study sleep age? When you sleep, you're disconnected from sensory inputs—you're, ideally, not being bothered by the noisy external world or bright lights. During sleep, it's not just the brain that's going through an automatic program, but heart rate and breathing also change, and variations in these can be early predictors of a health disturbance. We spend about a third of our lives sleeping, so it's a substantial component of our general well-being. It's well known that, in pretty much any disorder, sleep is one of the first things that is disturbed. For example, about five or 10 years before other symptoms appear in Parkinson's disease patients, a specific sleep disturbance occurs during which the patient violently acts out dreams, shouts or punches into a wall. What was the most important finding from the study? Our main finding was that sleep fragmentation—when people wake up multiple times throughout the night for less than a minute without remembering it—was the strongest predictor of mortality. Though we see a link in the data, how it contributes to mortality is unknown. This is different from a person realizing they were waking up, which happens during sleep disorders such as insomnia. Determining why sleep fragmentation is so detrimental to health is something we plan to study in the future. Can we measure our own sleep age? Can it be improved? The code is available for physicians and researchers, but the average person would likely have trouble running it through a computer. Regardless, it's not deterministic. There is enormous variation. Even if you have an older sleep age than your chronological age, it doesn't mean that your mortality risk is going to be higher. You see people chain smoking and drinking alcohol at 90 years old and you wonder, "How is this person surviving so long?" There is always huge natural variation. Going to bed and waking up at regular hours is a key to improving your sleep. This means not oversleeping but ensuring you're fully rested. It's a different amount for everyone and often the window varies slightly—for example, being a night owl versus an early bird. Getting solid light exposure—preferably with outside light—during the day, keeping the sleep environment dark at night, exercising regularly but not too close to bedtime, not drinking alcohol and caffeine around bedtime, and avoiding heavy nighttime meals all contribute to healthy sleep. And, of course, make sure any sleep disorder is treated. We found that people with older sleep ages compared to their actual age are at an increased risk of mortality, based on the sleep of patients who later died. From other studies, we know that poor sleep is found in a variety of conditions such as sleep apnea, neurodegeneration, obesity and chronic pain. How poor sleep causes, exacerbates or results from these conditions is unknown.

Pharmacological approaches to longevity using drugs like rapamycin and Acarbose via targeting signaling molecules like mTOR and insulin continue to see growing support. Today we speak with Bradley S Rosen MD whose practice focuses on Living Healthier and Longer through Biogerontology. Dr Rosen graduated with a degree in Mathematics and Statistics and an MD from the University of Florida. His residency was at Jules Stein Eye Institute at UCLA, followed by 2 Retina Fellowships at the Lions Eye Institute and the Royal Victorian Eye and Ear Hospital in Melbourne, Australia. In 2013 Dr. Rosen, M.D. joined a growing number of scientists and clinicians who are becoming increasingly interested in the fact that the hallmarks of aging themselves can and should be targeted for therapy.https://mtormd.com/ @DrBradleyRosen1Lu, Yuancheng, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, et al. “Reprogramming to Recover Youthful Epigenetic Information and Restore Vision.” Nature 588, no. 7836 (December 3, 2020): 124–29. https://doi.org/10.1038/s41586-020-2975-4.Jiang, Zhou, Juan Wang, Denise Imai, Tim Snider, Jenna Klug, Ruby Mangalindan, John Morton, et al. “Short Term Treatment with a Cocktail of Rapamycin, Acarbose and Phenylbutyrate Delays Aging Phenotypes in Mice.” Scientific Reports 12, no. 1 (December 2022): 7300. https://doi.org/10.1038/s41598-022-11229-1.https://www.nature.com/articles/s41598-022-11229-1 *** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/ Twitter:https://twitter.com/robertlufkinmdYoutube: https://www.youtube.com/RobertLufkinMD*** MEMBERSHIP ***https://robert-lufkin.mykajabi.com/membership *** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://robertlufkinmd.com/contact  NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel.Support the show

This episode is brought to you by ButcherBox and InsideTracker.We all know that fasting has amazing benefits: reduced inflammation, increased cognitive function, fat loss, decreased risk of metabolic dysfunction, and the list goes on and on. But is there a correct way to fast? Is fasting for everyone? Should we exercise while we fast? How do we make the most of our fasts and how do we optimize our diets when we aren't fasting? Today on The Dhru Purohit Podcast, Dr. Valter Longo answers all of these questions and more. Dhru and Dr. Longo discuss the key pillars of the Fasting Mimicking Diet (FMD), created by Dr. Longo to provide the body with the benefits of fasting without completely starving it. They also dive into the foundation of a longevity diet—how can we increase our lifespan and our healthspan using targeted nutrients and dietary protocols. Dr. Longo is internationally recognized as a leader in the field of aging studies and related diseases. Known as the “Guru of Longevity,” Dr. Longo is currently Professor of Biogerontology and Biological Sciences and Director of the Institute of Longevity of the School of Gerontology at the University of Southern California, as well as Director of the Oncology and Longevity Program at IFOM in Milan. He is also the Scientific Director of the Create Cures Foundation and the Valter Longo Foundation. Valter is the author of The Longevity Diet, a culmination of his 25 years of research on aging, nutrition, and disease across the globe. It provides an easy-to-understand, accessible, and implementable road map to living well longer through improved nutrition.In this episode, we dive into: -Why you shouldn't skip breakfast (2:23)-What happens if you fast incorrectly (13:59)-The key pillars of the Fasting Mimicking Diet (21:43)-Exercise and fasting (24:10)-The impact of the Fasting Mimicking Diet on chronic disease (31:05)-How the Fasting Mimicking Diet impacts the brain (35:18)-The foundation of the longevity diet (38:52)-Optimal protein consumption and longevity (51:02)-Why walking one hour a day is so central to longevity (1:04:14) -Stem-cell therapy and longevity (1:09:03)-Longevity supplement recommendations (1:15:57) For more on Dr. Valter Longo, follow him on Instagram @prof_valterlongo, Facebook @provalterlongo, and through his website, valterlongo.com. Get his book, The Longevity Diet, here.This episode is brought to you by ButcherBox and InsideTracker.Right now, ButcherBox is offering new members a great deal. You'll receive two pounds of FREE salmon in your first box. Sign up at ButcherBox.com/dhru.InsideTracker provides detailed nutrition and lifestyle guidance based on your individual needs. Right now, they're offering my podcast community 20% off. Just go to insidetracker.com/DHRU to get your discount and try it out for yourself. See acast.com/privacy for privacy and opt-out information.

This week Mikki speaks to Dr Darren Candow, one of the world's experts in creatine. They discuss the role of creatine in health and performance, what the research shows with regards to creatine as an ergogenic aid, and the emerging research that illustrates its role in brain and bone health. They also discuss the mis-information that exists with creatine and sets the story straight.Dr. Darren Candow, PhD, CSEP-CEP, is a Full Professor and Associate Dean-Graduate Studies and Research in the Faculty of Kinesiology & Health Studies, University of Regina. Dr. Candow supervises the Aging Muscle and Bone Health Laboratory and serves on the editorial review board for the Journal of Aging and Physical Activity, Journal of the International Society of Sports Nutrition, and Biogerontology. Dr. Candow has received over $1.5 million in research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, and the Nutricia Research Foundation and has published over 100 journal and knowledge dissemination articles involving exercise and nutrition. Dr. Candow also serves as the Chief Scientific Officer for TDF Sports. https://www.uregina.ca/kinesiology/faculty-staff/faculty/candow-darren.htmlContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenSave 20% on all NuZest Products with the code MIKKI20 at www.nuzest.co.nz

Dr. Judith Campisi, PhD (https://www.buckinstitute.org/lab/campisi-lab/) is a biochemist, cell biologist, and Professor of Biogerontology at the Buck Institute for Research on Aging. Dr. Campisi received a PhD in biochemistry from the State University of New York at Stony Brook and completed her postdoctoral training in cell cycle regulation at the Dana-Farber Cancer Institute and Harvard Medical School. As an assistant and associate professor at the Boston University Medical School, she studied the role of cellular senescence in suppressing cancer and soon became convinced that senescent cells also contributed to aging. She joined the Lawrence Berkeley National Laboratory as a senior scientist in 1991 working with Dr. Mina Bissell. In 2002, she started a second laboratory at the Buck Institute. At both institutions, Dr. Campisi established a broad program to understand the relationship between aging and age-related disease, with an emphasis on the interface between cancer and aging. Dr. Campisi is a member of the National Academy of Sciences and a fellow of the American Association for the Advancement of Science. Dr. Campisi has received numerous awards for her research, including two MERIT awards from the National Institute on Aging and awards from the AlliedSignal Corporation, Gerontological Society of America, and American Federation for Aging Research. She is a recipient of the Longevity prize from the IPSEN Foundation, the Bennett Cohen award from the University of Michigan, and the Schober award from Halle University, and she is the first recipient of the international Olav Thon Foundation prize in Natural Sciences and Medicine. Dr. Campisi currently serves on advisory committees for the Alliance for Aging Research, Progeria Research Foundation, and NIA's Intervention Testing Program. She is also an editorial board member for more than a dozen peer-reviewed journals. Dr. Campisi is a scientific founder of Unity Biotechnology, a California-based company focused on developing senolytic therapies for age-related pathologies. She has served on the scientific advisory boards of the Geron Corporation, Sierra BioScience, and Sangamo Biosciences.

Biogerontology is the study of aging. It's so fascinating to consider both lifestyle and other “hacks” to maintain optimal health as long as possible. Dr. Kahn discusses the latest research and the safest option that the science suggests using foods and a supplement to achieve a healthy and vibrant old age on this edition of Heart Doc VIP on Empower Radio.

M4M welcomes on Christina Grace FNP-C from Centre Spring MD to discuss integrative medicine, healthy aging, and the gut biome - INTERVIEW (1:00-35:00). EDUCATION: "food is medicine," aging, exercise, and sleep (35:30-42:00). TIP OF THE WEEK: Whoop & Sleep (42:20-46:00). TRIVIA (46:00-56:30).Visit https://centrespringmd.com/get-know-christina-grace-fnp-c/ for information on how to schedule with Christina Grace. For discounted supplements use the code "Made4More" at checkout: https://centrespringmd.com/shop/To check out the Whoop activity/recovery tracker check out: https://www.whoop.com

Fearless Training Roar Knowledge Podcast Episode 52: Dr. Darren Candow - All Things Creatine Welcome back to the Fearless Training "Roar Knowledge" Podcast where we talk everything; Training, Nutrition & Lifestyle. Dr. Darren Candow, PhD, CSEP-CEP, is Professor and Associate Dean-Graduate Studies and Research in the Faculty of Kinesiology & Health Studies. Dr. Candow supervises the Aging Muscle and Bone Health Laboratory, and serves on the editorial board for the Journal of Aging and Physical Activity, Journal of the International Society of Sports Nutrition, and Biogerontology. Dr. Candow has published 100 research articles, reports and abstracts. Dr. Candow's research program involves the development of effective resistance training and nutritional intervention strategies for improving properties of aging muscle and bone health. Dr. Candow's research is funded by the Canadian Institutes of Health Research (CIHR), Canada Foundation for Innovation (CFI), the Saskatchewan Health Research Foundation (SHRF), and the Nutricia Research Foundation. Instagram: https://www.instagram.com/dr.darrencandow/ Email: darren.candow@uregina.ca Follow Along For More Here: Fearless Training United Academy : http://fearlesstrainingunited.com Instagram: https://www.instagram.com/fearless_training_/ Facebook: https://www.facebook.com/FearlessTraining/?ref=bookmarks Youtube: https://www.youtube.com/channel/UCFaAxEHPYiM2ucqUs4-z54A?view_as=subscriber Coaching/Business Inquiries: alex@fearlesstraining.org Stay Fearless!

At NBT, one of the first things our clients do is complete a food diary. This helps us quickly identify any problems with macronutrients, micronutrients, and meal timing. What we’ve seen over the years is that few people - even those eating a Paleo-type diet - are consuming enough protein. This can have immense consequences on longevity, blood glucose management, and maintaining a healthy weight. In this interview, NBT Scientific Director Megan Hall and I talk about the importance of getting adequate dietary protein. Megan discusses the current recommended daily allowance (RDA) of protein compared to optimal levels needed to support muscle mass and strength as we age. We talk about protein myths and misconceptions and outline protein requirements for specific populations, including athletes and those following weight-loss diets. Here’s the outline of this interview with Megan Hall: [00:02:16] Why protein is so important. [00:02:28] Muscle mass and strength as a powerful predictor of longevity; Studies: 1. Rantanen, Taina, et al. "Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort." Age 34.3 (2012): 563-570; 2. Srikanthan, Preethi, and Arun S. Karlamangla. "Muscle mass index as a predictor of longevity in older adults." The American journal of medicine 127.6 (2014): 547-55; 3. McLeod, Michael, et al. "Live strong and prosper: the importance of skeletal muscle strength for healthy ageing." Biogerontology 17.3 (2016): 497-510; 4. Burd, Nicholas A., et al. "Dietary protein quantity, quality, and exercise are key to healthy living: a muscle-centric perspective across the lifespan." Frontiers in nutrition 6 (2019): 83. [00:05:30] Glucose disposal. [00:06:22] Maintaining a healthy weight; Protein leverage hypothesis. Study: Simpson, Stephen J., and David Raubenheimer. "Obesity: the protein leverage hypothesis." obesity reviews 6.2 (2005): 133-142. [00:07:38] Dr. Ted Naiman; Protein dilution. [00:08:18] Protein recommendations; Current RDA vs. optimal intake. [00:11:02] How protein is prepared matters; Study: Pennings, Bart, et al. "Minced beef is more rapidly digested and absorbed than beef steak, resulting in greater postprandial protein retention in older men." The American journal of clinical nutrition 98.1 (2013): 121-128.  [00:13:00] Fasting and protein restriction could be detrimental for older population. [00:13:43] Protein needs for athletes. [00:15:06] Protein needs for individuals following weight loss/calorie deficit diets. [00:16:02] Ideal timing for protein intake. [00:16:25] Protein spread evenly throughout the day is ideal; Study: Areta, José L., et al. "Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis." The Journal of physiology 591.9 (2013): 2319-2331.  [00:16:46] Leucine threshold; 3 grams is required to stimulate mTOR. [00:17:56] Myths about protein consumption. [00:18:28] Effect of protein on kidneys; high BUN blood marker. [00:19:42] Effects of high protein diets on bone health. [00:20:31] Myth that mTOR stimulation is bad. Study by Valter Longo: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417.  [00:22:50] Book: The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health, by Justin Sonnenberg and Erica Sonnenberg. [00:24:25] Myth: Animal protein is bad for the environment. [00:24:36] Podcast: Kale vs Cow: The Case for Better Meat, with Diana Rodgers. [00:24:59] Podcast: The Serengeti Rules: The Quest to Discover How Life Works and Why It Matters, with James Estes, PhD. [00:26:00] Myth: BCAAs are necessary. [00:26:34] Myth: Too much protein will kick you out of ketosis; Video: Dr. Benjamin Bikman - 'Insulin vs. Glucagon: The relevance of dietary protein'. [00:29:31] Myth: the body can only use 20-25g of protein at a time; Study: Schoenfeld, Brad Jon, and Alan Albert Aragon. "How much protein can the body use in a single meal for muscle-building? Implications for daily protein distribution." Journal of the International Society of Sports Nutrition 15.1 (2018): 1-6. [00:31:20] What we often see with our NBT clients. [00:33:12] How Megan and Chris gets their protein throughout the day. [00:36:05] Keeping quick protein around and ready to go. [00:36:43] High vs. low quality protein; plant protein vs. animal protein. [00:41:00] Arsenic in baby food made from rice; Report: What’s in my baby’s food? [00:42:49] Resistance exercise as a critical part of healthy aging. [00:44:29] Podcast: How to Get Motivated, with Simon Marshall, PhD. [00:46:18] Eat the protein first for glucose regulation and appetite control; Study: Nesti, Lorenzo, Alessandro Mengozzi, and Domenico Tricò. "Impact of nutrient type and sequence on glucose tolerance: physiological insights and therapeutic implications." Frontiers in endocrinology 10 (2019): 144. [00:47:26] NBT on Patreon.

Food has an amazing ability to heal, but the timing of when we eat or abstain from eating can also have really amazing impacts on our health. Autoimmunity, gut issues, Alzheimer’s, and aging have all been found to benefit from the right kind of fasting. In this mini-episode, Dr. Hyman sits down with Dr. Valter Longo to discuss the Fasting Mimicking Diet, a diet that helps you feel fed and nourished without completely starving the body, and has been found to support anti-inflammatory gut bacteria and support the mechanisms that lead to better aging. Dr. Valter Longo is internationally recognized as a leader in the field of aging studies and related diseases. Known as a “Guru of Longevity,” Dr. Longo is currently Professor of Biogerontology and Biological Sciences and Director of the Institute of Longevity of the School of Gerontology at the University of Southern California in Los Angeles, as well as Director of the Oncology and Longevity Program at IFOM in Milan. He is also the Scientific Director of the Create Cures Foundation and the Valter Longo Foundation. Valter is the author of, “The Longevity Diet.” The culmination of 25 years of research on aging, nutrition, and disease across the globe, it provides an easy-to-understand, accessible and implementable road map to living well longer through improved nutrition.Listen to Dr. Hyman’s full- length conversation with Dr. Valter Longo: https://DrMarkHyman.lnk.to/ValterLongo See acast.com/privacy for privacy and opt-out information.

Dr. Carvalho is a research scientist at USC. He has published peer-reviewed articles in the medical literature on topics ranging from nutrition to molecular biology, genetics and neuroscience". We discuss his research into Biogerontology and the science of what makes us age, mechanistic research into why we should and should not eat certain foods as well as the controversy surrounding nutritional epidemiology and why some people consider this poor science. Join us in one of my favorite episodes of 2019.  You can find his publications here: https://scholar.google.com/citations?user=O-_jWUkAAAAJ&hl=en Follow Gil on YouTube: https://www.youtube.com/channel/UCosmc75v-B2Dk7GWyEyFFMw/videos And on Twitter: https://twitter.com/NutritionMadeS3

SO I’VE BEEN THINKING ABOUT THE CONVERSATION **THAT WE DID NOT HAVE THE OTHER NIGHT** AND THE DINNER **THAT BILLY DID NOT COOK THE OTHER NIGHT-** WHAT WE DID THO - WAS GO OUT TO ONE OF THE LOCAL CHAIN RESTAURANTS, ALBEIT ONE OF THE BETTER ONES TO HAVE A HAMBURGER. IT WAS KINDA NICE TO HAVE THAT BREAK FROM ALL THAT GOURMET COOKING - ADMIRING BILLS TECHNIQUE IN CREATING OUTSTANDING MEALS, SOME OF WHICH ARE ORIGINAL, SOME OF WHICH ARE JUST BETTER VERSIONS OF THE ONES WE HAVE IN RESTAURANTS. BUT I DIGRESS. IT WAS WHILE EATING THE HAMBURGER THAT I WAS EAVESDROPPING AMONG THE GUESTS SITTING AROUND US WHEN I OVERHEARD AN INTERESTING CONVERSATION ONE MORE SENIOR WOMAN COMPLAINED THAT SHE HADN’T DONE HER MAKEUP, AND THE GENTLEMEN SITTING ACROSS FROM HER ( I CAN ONLY ASSUME THAT WAS HER HUSBAND SAID “SARAH, WHAT DO YOU NEED MAKEUP FOR - WHO ARE YOU TRYING TO ATTRACT AT YOUR AGE. AT WHICH TIME THE OTHER WOMAN AT THE TABLE SAID. WELL HONEY YOU ARE LUCKY - AT YOUR AGE YOU ARE FREE NOW, YOU DON’T NEED MAKEUP ANYMORE. AT WHICH TIME SARAH SAID - ITS NOT THE MAKEUP, BUT THE FACT THAT I FORGOT TO PUT IT ON. THERE WERE SO MANY THINGS TO UNPACK IN THAT CONVERSATION - VANITY, AGING, BRAIN FUNCTION - SO I THOUGHT I’D SEARCH OUT SOME TRULY REMARKABLE PEOPLE TO ADDRESS MANY OF THOSE ISSUES. SO THAT’S WHAT WE’LL YAK ABOUT TODAY.---   Let’s face it people in western society are vain. Looking good is almost mandatory. You walk down the street in the big cities and they are teaming with fit, well clothed people with skin that is silky smooth. But often you see some men and woman, looking a bit disheveled, glasses held up by the tip of the nose. no makeup (not homeless) I just assume that they are intellectuals, professors, scientists etc. WHO DON’T FALL INTO SOCIETIES EXPECTATIONS ON BEAUTY I’ve always wondered what do those people think about Vanity. So I went and searched out someone who could give us a point of view of what the cost of vanity is. # Scilla ELWORTHSCILLA ELWORTHY [Dare to Question Why We Are So Afraid of Getting Older: Scilla Elworthy at TEDxMarrakesh 2012 - YouTube](https://youtu.be/J6zenOjPC1A)https://youtu.be/J6zenOjPC1A is the founder of the Oxford Research Group, a non-governmental Organisation she set up in 1982 to develop effective dialogue between nuclear weapons policy-makers worldwide and their critics. She served as its executive director from 1982 until 2003, when she left that role in order to set up Peace Direct, a charity THA SUPPORTS local peace builders in conflict areas. From 2005 she was adviser to Peter Gabriel, Desmond Tutu and Richard Branson in setting up The Elders. She is a member of the World Future Council and the International Task Force on Preventive Diplomacy. She has been nominated three times for the Nobel Peace Price and in 2003 she was awarded the Niwano Peace Prize for her work with the Oxford Research Group. ------# DR. THAD POLK DR. DAVID POLK - AGING IS NOT WHAT YOU THINK[Aging: It’s Not What You Think | Thad Polk | TEDxUofM - YouTube](https://youtu.be/wrTIS0uKg6o)https://youtu.be/wrTIS0uKg6o   e often talk about memory loss as we age. We’ve learned the tricks to help us out. Just ask Brad Zupp, our memory athlete. As a result, common wisdom says that age isn’t too kind to our minds abilities. But can iT brain actually be improving as we age. So why not look for someone who can explain it. Our brains are powerful pieces of machinery that give us the capacity to do amazing things. Unfortunately, common wisdom says that age isn’t too kind to our minds’ abilities. Neuroscientist Thad Polk walks through the actual effects of aging on the human brain and shows that our assumptions might not be so accurate.Dr. Thad Polk has been a member of the University of Michigan psychology faculty since 1996. he was named an Arthur F. Thurnau Professor in recognition of outstanding contributions to undergraduate education, and in 2012 Princeton Review included him on its list of the Best 300 Professors in the US. ------ # David Andrew Sinclair DAVID SINCLAIR - SLOWING DOWN AGING [David Sinclair Slowing down Aging - YouTube](https://youtu.be/9bhDgBhRgtk) https://youtu.be/9bhDgBhRgtkDR. DAVID POLK - AGING IS NOT WHAT YOU THINK[Aging: It’s Not What You Think | Thad Polk | TEDxUofM - YouTube](https://youtu.be/wrTIS0uKg6o)https://youtu.be/wrTIS0uKg6o hile we are speaking of aging. You constantly here that there is research being done that will slow down the aging process or halt it altogether - God forbid you have to live with that difficult family member forever. I tried to find someone who can explain in simple terms - what research is being done to slow down the aging process. HIS NAME IS DAVID SINCLAIR AND HE is an Australian biologist and Professor of Genetics best known for his research on the biology of lifespan extension and driving research towards treating diseases of aging. Sinclair is Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Sinclair obtained a Bachelors of Science (Honours Class I) at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at the Massachusetts Institute of Technology with Leonard Guarente.Since 1999 he has been a tenured professor in the Genetics Department of Harvard Medical School. Sinclair has received over 25 awards including The Australian Commonwealth Prize, A Helen Hay Whitney Fellowship, the Nathan Shock Award, a Leukemia and Lymphoma Fellow, a MERIT Awards from the National Institutes of Health, the Merck Prize, the Arminese Fellowship, the Genzyme Outstanding Achievement in Biomedical Science Award, an Ellison Medical Senior Fellow, the Bio-Innovator award, the Bright Sparks Award for Top Scientists under 40, The Denham Harman Award in Biogerontology, a medal from the Australian Society for Medical Research, and a TIME 100 honoree, TIME magazine’s list of the 100 “most influential people in the world” (2014).———— ------# Jane Caro JANE CARO[Growing old: The unbearable lightness of ageing | Jane Caro | TEDxSouthBank - YouTube](https://youtu.be/ULqf3OyemZY)https://youtu.be/ULqf3OyemZY Jane Caro has a low boredom threshold and so wears many hats; including author, novelist, lecturer, mentor, social commentator, columnist, workshop facilitator, speaker, broadcaster and award winning advertising writer. The common thread running through her career is a delight in words and a talent for using them to connect with other people. @JaneCaro@TEDxSouthBank This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at [http://ted.com/tedx](https://www.youtube.com/redirect?event=video_description&v=ULqf3OyemZY&q=http%3A%2F%2Fted.com%2Ftedx&redir_token=Tr5pUh70swXaZsz0iwgFjacJeTR8MTU2Mjg1NjU2MUAxNTYyNzcwMTYx) My tits don’t hurt: Ever ---- I want to thank our sponsor for making Yak About Today possible AND THE NUMBER ONE TALK RADIO STATION IN OUR MARKET. We couldn’t do half of what we do without them. But that wouldn’t mean much if we didn’t believe in them. To my mind and many others they are simply the best practice to go to for both prevention as well as more serious eye conditions. So like i always say - go see Drs. Minotti Rhinehour, tate and o’brien because i wouldn’t trust my eyes to anyone else --- DAVID SINCLAIR - SLOWING DOWN AGING [David Sinclair Slowing down Aging - YouTube](https://youtu.be/9bhDgBhRgtk) https://youtu.be/9bhDgBhRgtkDR. DAVID POLK - AGING IS NOT WHAT YOU THINK[Aging: It’s Not What You Think | Thad Polk | TEDxUofM - YouTube](https://youtu.be/wrTIS0uKg6o)https://youtu.be/wrTIS0uKg6o SCILLA ELWORTHY[Dare to Question Why We Are So Afraid of Getting Older: Scilla Elworthy at TEDxMarrakesh 2012 - YouTube](https://youtu.be/J6zenOjPC1A)https://youtu.be/J6zenOjPC1A JANE CARO[Growing old: The unbearable lightness of ageing | Jane Caro | TEDxSouthBank - YouTube](https://youtu.be/ULqf3OyemZY)https://youtu.be/ULqf3OyemZY   ----------------------------------------------------------------- # SOCIAL MEDIA STUFF#yakabouttoday/SOCIAL Social Media Attachment for all publications “YOU CANT GO BACK AND CHANGE THE BEGINNING BUT YOU CAN START WHERE YOU ARE AND CHANGE THE ENDING. The Yak About Today broadcasts deliver on air and online conversations, interviews and stories engaging the Baby Boomer Generation and beyond with discussions, tips and information. YOU CAN FIND US ON THE STATIONS WAXE 107.9, WZTA 1370 AM AND REAL RADIO 101.7 IN FLORIDA AND OF COURSE ON ALL MAJOR PODCASTING SYSTEMS.YOU CAN ALSO GET US AT YAKABOUTTODAY.COM AND FACEBOOK AND TWITTER AND ALL SOCIAL PLATFORMS, JUST LOOK FOR YAK ABOUT TODAY. OR WRITE ME AT YAKABOUTTODAY@GMAIL.COM Hosted by an authentic conversationalist, intuitive listener and a boomer himself, David Yakir brings a genuine, down to earth and disarming personality that talks with his audience and his guests with out talking at them. David shares Engagement, Education, Enjoyment & Empowerment on air and online for the BabyBoomer Generation delivered with humor, wit and thought. Yak About Today is your GPS guide for technology, fitness, , finance entrepreneurship, entrepreneurship & all things that mean anything to you. For more information, visit: [http://yakirgroup.com/](http://yakirgroup.com/) [http://facebook.com/yakabouttoday/](http://facebook.com/yakabouttoday/) [http://twitter.com/yakabouttoday/](http://twitter.com/yakabouttoday/) [http://spanishriverconcerts.com](http://spanishriverconcerts.com)  

These days, we hear a lot about fasting. Intermittent fasting, time-restricted eating, and water fasting are just some of the many terms being thrown around in support of better health. And we can’t forget about the high-fat, ketogenic, and low-carb approaches that are gaining in popularity as well. Which one is best? What does it all mean for our longevity, brain health, and overall wellness? My guest on this week’s episode of The Doctor’s Farmacy is here to sift through the terminology and confusion around fasting.Dr. Valter Longo is internationally recognized as a leader in the field of aging studies and related diseases. Known as a “Guru of Longevity,” Dr. Longo is currently Professor of Biogerontology and Biological Sciences and Director of the Institute of Longevity of the School of Gerontology at the University of Southern California in Los Angeles, as well as Director of the Oncology and Longevity Program at IFOM in Milan. He is also the Scientific Director of the Create Cures Foundation and the Valter Longo Foundation. Valter is the author of an extraordinary new book, The Longevity Diet. The culmination of 25 years of research on aging, nutrition, and disease across the globe, it provides an easy-to-understand, accessible and implementable road map to living well longer through improved nutrition. See acast.com/privacy for privacy and opt-out information.

How long can we live? How much of aging is genetics vs. environment? What does oral hygiene have to do with brain health? What causes Alzheimer’s? How do turtles and naked mole rats live so long? Are there any proven strategies for living a longer life? What's up with whiskey and eggs? World-renowned aging expert and biogerontologist Dr. Caleb "Tuck" Finch takes a quick break from his prolific research at USC to answer Alie's sometimes stupid questions about everything from molecules to movies. And she only has like, 3 life-altering epiphanies during the episode. This week's donation was made to CureALZ.org More links at www.alieward.com/ologies/biogerontology "I don't have time for bullshit" pen by Cole Imperi Become a patron of Ologies for as little as a buck a month: www.Patreon.com/ologies OlogiesMerch.com has hats, shirts, pins, totes! Follow @Ologies on Twitter or Instagram Follow @AlieWard on Twitter or Instagram Sound editing by Steven Ray Morris & Jarrett Sleeper Theme song by Nick Thorburn Support the show.

Researcher Jon Ramsey, PhD is Professor in the Department of Molecular Biosciences within the School of Veterinary Medicine at UC Davis. His study of animals focuses on nutrition as it relates to obesity and aging. The goal of his research is to understand the biological mechanisms that contribute to the aging process and to develop dietary interventions that promote healthy aging and weight loss. In this podcast, NBT Scientific Director Megan Roberts interviews Dr. Ramsey about his research in the area of calorie restriction and its beneficial effects on longevity and healthspan. They examine the scientific literature on energy and macronutrient restriction, including some of the possible biological mechanisms driving the anti-aging effects of these interventions. They also discuss what this all means in practical terms for those seeking optimal health as they age. Here’s the outline of this interview with Jon Ramsey: [00:01:35] Calorie restriction for increasing lifespan. [00:02:01] Theories of aging. [00:04:40] Osborne and Mendel; Study: Osborne, Thomas B., Lafayette B. Mendel, and Edna L. Ferry. "The effect of retardation of growth upon the breeding period and duration of life of rats." Science 45.1160 (1917): 294-295. [00:04:58] Clive McCay; Studies: McCay, Clive Maine, and Mary F. Crowell. "Prolonging the life span." The Scientific Monthly 39.5 (1934): 405-414 and McCay, Carl M., Mary F. Crowell, and Lewis A. Maynard. "The effect of retarded growth upon the length of life span and upon the ultimate body size: one figure." The journal of Nutrition 10.1 (1935): 63-79. [00:06:25] Calorie restriction literature in animals. [00:07:39] Types of rodents studied. [00:08:09] Comparing effect of caloric restriction (CR) on different strains of mice; Study: Liao, Chen‐Yu, et al. "Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening." Aging cell 9.1 (2010): 92-95. [00:09:08] Time restricted feeding in animal models. [00:11:51] Calorie restriction vs. malnutrition. [00:12:00] Different levels of calorie restriction. Study: Weindruch, Richard, et al. "The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake." The Journal of nutrition 116.4 (1986): 641-654. [00:13:36] Effects of 10% dietary restriction: Richardson, Arlan, et al. "Significant life extension by ten percent dietary restriction." Annals of the New York Academy of Sciences 1363.1 (2016): 11-17. [00:15:09] CALERIE study and resulting Publications. [00:17:56] Analyses of CALERIE data. Studies: Belsky, Daniel W., et al. "Change in the rate of biological aging in response to caloric restriction: CALERIE Biobank Analysis." The Journals of Gerontology: Series A 73.1 (2017): 4-10. and Redman, Leanne M., et al. "Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging." Cell metabolism 27.4 (2018): 805-815. [00:19:21] Dietary restriction and oxidative stress; Study: Walsh, Michael E., Yun Shi, and Holly Van Remmen. "The effects of dietary restriction on oxidative stress in rodents." Free Radical Biology and Medicine 66 (2014): 88-99. [00:20:29] Podcast: How Oxidative Stress Impacts Performance and Healthspan, with Megan Roberts. [00:20:40] Effects of CR on reactive oxidative species production; Study: Ramsey, Jon J., Mary-Ellen Harper, and Richard Weindruch. "Restriction of energy intake, energy expenditure, and aging." Free Radical Biology and Medicine 29.10 (2000): 946-968. [00:20:59] Effects of fasting on the liver; Study: Salin, Karine, et al. "Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost." Functional Ecology (2018). [00:21:56] Control of food intake: Do animal models accurately reflect human behavior? [00:25:06] Enriched environment; Study: McMurphy, Travis, et al. "Implementation of environmental enrichment after middle age promotes healthy aging." Aging (Albany NY) 10.7 (2018): 1698. [00:26:16] Monkey studies; Study: Ramsey, J. J., et al. "Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study." Experimental gerontology 35.9-10 (2000): 1131-1149. [00:26:35] University of Wisconsin study: Colman, Ricki J., et al. "Caloric restriction delays disease onset and mortality in rhesus monkeys." Science 325.5937 (2009): 201-204. [00:26:35] National Institute on Aging study: Mattison, Julie A., et al. "Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study." Nature 489.7415 (2012): 318. [00:31:34] Biological mechanisms behind the beneficial effects of CR. [00:33:09] Central metabolism sensors. [00:35:28] Mitochondrial proton leak. [00:37:41] Study: Bevilacqua, Lisa, et al. "Effects of short-and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production." American Journal of Physiology-Endocrinology and Metabolism 286.5 (2004): E852-E861. [00:40:59] The influence of dietary fat source; Study: Villalba, José Manuel, et al. "The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice." Biogerontology 16.5 (2015): 655-670. [00:42:16] Effects of protein restriction on longevity; Studies: 1. Davis, Teresa A., Connie W. Bales, and Roy E. Beauchene. "Differential effects of dietary caloric and protein restriction in the aging rat." Experimental gerontology 18.6 (1983): 427-435; 2. Pugh, Thomas D., Roger G. Klopp, and Richard Weindruch. "Controlling caloric consumption: protocols for rodents and rhesus monkeys☆." Neurobiology of aging 20.2 (1999): 157-165. [00:42:23] More recent studies on protein restriction: 1. Pamplona, Reinald, and Gustavo Barja. "Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection." Biochimica Et Biophysica Acta (BBA)-Bioenergetics 1757.5-6 (2006): 496-508; 2. Caro, Pilar, et al. "Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver." Biogerontology 10.5 (2009): 579-592. [00:43:42] Morris Ross study: Ross, Morris H. "Length of life and nutrition in the rat." The Journal of nutrition 75.2 (1961): 197-210. [00:44:03] Effects of dietary lipid composition on lifespan; Study: López-Domínguez, José A., et al. "The influence of dietary fat source on life span in calorie restricted mice." Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 70.10 (2014): 1181-1188. [00:45:07] Anthony J. Hulbert. [00:48:46] Omega-3 study: Aung, Theingi, et al. "Associations of omega-3 fatty acid supplement use with cardiovascular disease risks: meta-analysis of 10 trials involving 77 917 individuals." JAMA cardiology 3.3 (2018): 225-234. [00:50:02] Ketogenic Diets. [00:50:05] Study: Roberts, Megan N., et al. "A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice." Cell Metabolism 26.3 (2017): 539-546. Podcast: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice, with Megan (Hall) Roberts. [00:53:47] Intermittent fasting study: Mitchell, Sarah J., et al. "Daily fasting improves health and survival in male mice independent of diet composition and calories." Cell metabolism(2018). [00:54:19] Valter Longo, PhD. [00:54:49] Weight cycling; Study: Smith Jr, Daniel L., et al. "Weight cycling increases longevity compared with sustained obesity in mice." Obesity 26.11 (2018): 1733-1739. [00:55:22] Exercise in the context of carb restriction and longevity. [00:56:08] Study: Holloszy, John O., et al. "Effect of voluntary exercise on longevity of rats." Journal of applied physiology 59.3 (1985): 826-831. [00:58:41] Take home points. [01:01:08] With unlimited resources, what would you study? [01:02:08] Jon Ramsey, PhD at UC Davis.

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]

Geriatrician Dr. John Newman looks at therapies that target mechanisms of aging to prevent, delay, or treat a wide range of age-related diseases and conditions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 33743]

As a professor of biogerontology at the University of Brighton, Richard Farragher has served as Chair of the British Society for Research on Ageing and the International Association of Biomedical Gerontology. He joins the podcast today to discuss something that affects us all: the process of ageing. “Understanding how ageing works is a prerequisite to improving later life health,” says Farragher. So, how does it work? While research efforts to answer this question are ongoing, Farragher believes that there are three primary mechanisms of ageing: the cessation of cell division (aka ‘cellular senescence'), the decline in efficiency of nutrient recycling in the body, and the restriction of a DNA-based process referred to as ‘slicing.' Farragher explains each one in detail and explores the ways in which they could be addressed in order to improve and prolong health. Farragher will be speaking at New Scientist Live in the UK this September, and is always happy to answer questions via email. Tune in for the full discussion.

Try Squarespace for free: http://www.squarespace.com/MINUTEEARTH The human lifespan might be limited, in part, because natural selection just stops working late in life. Thanks to our Patreon patrons https://www.patreon.com/MinuteEarth and our YouTube sponsors for helping to make this video possible. ___________________________________________ Video Keywords: Mortality plateau: the leveling out of the mortality rate that is observed at late ages in various species ___________________________________________ Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ And visit our website: https://www.minuteearth.com/ Say hello on Facebook: http://goo.gl/FpAvo6 And Twitter: http://goo.gl/Y1aWVC And download our videos on itunes: https://goo.gl/sfwS6n ___________________________________________ Credits (Twitter handles): Script Writer: Kate Yoshida (@KateYoshida) Script Editor: Alex Reich and David Goldenberg Video Illustrator: Arcadi Garcia Rius Video Director: David Goldenberg and Emily Elert Video Narrator: Emily Elert (@eelert) With Contributions From: Henry Reich, Alex Reich, Ever Salazar, Peter Reich Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder ___________________________________________ References: De Grey, A (Sept 2016, personal communication) Horiuchi S, Wilmoth JR (1998) Deceleration in the Age Pattern of Mortality at Older Ages. Demography 35: 4. https://link.springer.com/article/10.... Mueller, LD, Rose MR (1996) Evolutionary theory predicts late-life mortality plateaus. PNAS 26:15249-15253. https://doi.org/10.1073/pnas.93.26.15249 Rose MR, Rauser CL, Mueller LD, Benford G. (2006) A revolution for aging research. Biogerontology 7:269-77. https://www.ncbi.nlm.nih.gov/pubmed/1... Rose, MR, Flatt, T, Graves, JL, Greer, L, Martinez, DE, Matos, MM, Mueller, LD, Shmookler Reis, RJ, and P. Shahrestani. 2012. What is aging? Frontiers in Genetics 3:134. https://www.frontiersin.org/articles/... Rose, M. (Sept 2016, personal communication)