Aging and Senior Health (Audio)

Psychological resilience in later life examines how older adults adapt after adversity and cultivate everyday practices that sustain well-being and purpose.Elizabeth W. Twamley, Ph.D., introduces and guides a discussion on mental health and resilience among older adults. Ellen E. Lee, M.D., characterizes resilience as dynamic learning oriented toward flourishing and urges a low threshold for seeking help when symptoms overwhelm daily routines. Sidney Zisook, M.D., presents grief as adaptation to loss, distinguishes acute from integrated grief, and explains how intense waves of emotion gradually become less frequent and more manageable; he views psychedelic therapies as promising but not ready for routine treatment. Marti E. Kranzberg shares practical approaches that include mindfulness, journaling, gratitude, movement, sleep, pain management, creative arts, time in nature, community, and purpose. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40963]

Cognitive resilience grows from small, consistent habits that keep the brain adaptable. Fadel Zeidan, Ph.D., frames mindfulness as mental training that improves attention, processing, and the way people relate to pain. Erin E. Sundermann, Ph.D., underscores modifiable pathways to healthier aging, highlighting movement, social connection, hearing support, and lifelong learning as mutually reinforcing drivers of brain health. Raenne C. Moore, Ph.D., centers practical strategies that translate into daily life, including routines, planned breaks, reducing distractions, and attending to anxiety or depression. Carolyn Dunmore, an older adult community Mmmber, exemplifies resilience through steady activity, purposeful community roles, faith, self-compassion, and the “use it or lose it” mindset. Together, Zeidan, Sundermann, Moore, and Dunmore point to a clear theme: everyday practices accumulate to support memory, attention, and well-being as people age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40962]

Targeting the biology of aging offers a path to stronger resilience and longer health. John C. Newman, M.D., Ph.D., explains that aging arises from measurable cellular processes, often called hallmarks of aging, including changes involving mitochondria, stem cells, cellular senescence, inflammation, and protein quality control. Newman describes how basic science in model organisms reveals mechanisms that can be manipulated to extend healthy lifespan and guide therapies. Emerging approaches aim either to strengthen stress responses that make cells more resilient or to address downstream consequences. Many clinical studies across the country now test interventions that target aging, supported by national efforts to standardize methods and expand training. Newman also investigates ketone bodies as energy sources that influence inflammation, muscle preservation, and other processes relevant to frailty and recovery. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40961]

Healthy aging starts with physical resilience, the body's ability to withstand and recover from stress. Maile Young Karris, M.D., defines the concept and sets the stage for practical strategies that match real-world needs. Ryan J. Moran, M.D., M.P.H., recommends simple routines such as wall push ups, posture alignment, and chin tucks, and he links posture and vision to fall prevention; social connection helps people stick with movement. Theodore Chan, M.D., F.A.C.E.P., F.A.A.E.M., explains that age alone is a poor predictor of outcomes in acute care and that functional resilience strongly influences decisions. Gail Levine emphasizes accountability, community, and balanced nutrition. Moran highlights protein needs of about 1 to 1.2 grams per kilogram plus calcium with possible vitamin D, and he favors plant focused eating with limited processed foods. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40960]

Heather E. Whitson, MD, MHS explores how resilience—the ability to recover and adapt after stress or illness—changes across the lifespan. She explains that bounce back slows with age and that people age at different rates, influenced by biology, lifestyle, and environment. Studies connect lower inflammation, stronger cellular health, and emotional well-being to better recovery, such as regaining mobility after hip fracture or coping with persistent pain. Whitson also highlights how changes in the brain, like the buildup of amyloid and tau proteins, begin years before memory problems, underscoring the importance of early prevention. She points to practical steps that support resilience at any age: staying active, eating a Mediterranean style diet, managing blood pressure and blood sugar, protecting vision, engaging socially and mentally, prioritizing sleep, avoiding harmful exposures, and preventing injuries. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40959]

Danielle K. Glorioso, LCSW, explores the complex nature of grief, emphasizing that it is a lifelong, evolving response to loss rather than something to “get over.” She explains the differences between acute grief, integrated grief, and prolonged grief disorder, highlighting how factors like attachment, personal history, and circumstances of death can influence the grieving process. Glorioso outlines how prolonged grief can impair daily functioning and discusses effective treatments, including a structured therapy program that facilitates adaptation. She also examines resilience as a skill that can be strengthened through emotion regulation, cognitive flexibility, social support, and meaning-making. Drawing on both professional expertise and personal loss, Glorioso offers practical strategies for coping, supporting others, and finding hope while honoring the memory of loved ones. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40332]

Michael J. Wilkinson, M.D., F.A.C.C., F.N.L.A., explores the science and clinical evidence behind intermittent fasting and its role in promoting cardiometabolic health. He explains how aligning eating patterns with the body's natural circadian rhythms can improve weight, blood pressure, glucose regulation, and other risk factors, especially in individuals with metabolic syndrome or type 2 diabetes. Wilkinson highlights promising results from time-restricted eating studies conducted in collaboration with UC San Diego and the Salk Institute, where narrowing the daily eating window led to improved metabolic markers and potential benefits beyond weight loss. He also outlines practical tips for safely adopting this lifestyle approach and stresses the importance of ongoing research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40319]

Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]

Anthony Molina, Ph.D. highlights research and resources from the Stein Institute for Research on Aging that support healthy aging, with a focus on women's health. He describes the institute's work in training scientists, conducting clinical trials, and promoting community engagement. Key resources include a geroscience lab for biomarker discovery, new facilities for exposome and epigenetics research, and a clinical center for geriatric assessments. Molina also introduces the SAGE study—a 15-year prospective cohort project—and a “living lab” that enables real-world studies on technology and aging. The institute offers pilot funding for early-stage research and fosters intergenerational programs connecting older adults with medical students. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40767]

Andrea Z. LaCroix, Ph.D. presents major public health trends affecting women across the lifespan, from rising maternal mortality and chronic disease risks linked to pregnancy complications to the ongoing need for improved menopause care. She highlights innovative research, including digital tools for menopause education, studies on cancer survivorship, and efforts to predict healthy aging using epigenetic clocks and physical activity data. LaCroix shows how decades of research continue to shape strategies for aging with preserved cognitive and physical function, aiming to help more women thrive into their 90s and beyond. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40766]

In this excerpt, Dr. Natalie Marshall discusses the central importance of exercise to improve chromosomal and telomere health. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40683]

Fadel Zeidan, Ph.D., discusses the science of mindfulness and how meditation can change the brain. He explains what happens in the brain during stress, how mindfulness helps us become more self-aware, and why it's important to pay attention on purpose. Zeidan shares easy ways to bring mindfulness into daily life, even in small moments. The video includes guided meditations led by Zeidan. Viewers can follow along as he teaches simple breathing techniques and short practices designed to build focus and calm the nervous system. Whether you're new to meditation or looking to deepen your practice, this program offers useful tools backed by science. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40267]

Dr. Terence Friedlander reviews the various patient outcomes after hip fracture surgery. Series: "Excerpts" [Health and Medicine] [Show ID: 40752]

The risk for many chronic diseases is directly linked to metabolic changes in the body and loss of muscle mass often associated with aging. In this excerpt, Dr. Natalie Marshall focuses on the role that muscles play in the body. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40685]

Dr. Terence Friedlander discusses common issues brought on by osteoporosis. Series: "Excerpts" [Health and Medicine] [Show ID: 40751]

How can you make choices today that could help you live longer and feel better? Gordon Saxe, M.D., Ph.D., explores the ways to slow the aging process and live a healthier life. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40601]

The risk for many chronic diseases is directly linked to metabolic changes in the body and loss of muscle mass often associated with aging. In this program, Dr. Natalie Marshall focuses on sarcopenia, low muscle mass, and the importance of strength training and body composition to improve metabolic fitness. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40684]

The risk for many chronic diseases is directly linked to metabolic changes in the body. In this program, Dr. Natalie Marshall focuses on the role of antioxidants and how they work against oxidative stress in the body. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40682]

How can you make choices today that could help you live longer and feel better? Gordon Saxe, M.D., Ph.D. explores lifestyle choices, including diet, that can prevent, or slow, chronic diseases and improve overall health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40600]

Michael J. Corley, Ph.D., explores groundbreaking research on aging, the role of ancient viruses in our DNA, and the impact of the gut microbiome on longevity. Corley discusses how stress, diet, and exercise influence our genetic health, highlighting the complex interplay between environmental factors and our biological systems. The conversation also touches on individualized treatment strategies and the exciting potential of microbiome science in aging research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40266]

What's the secret to supporting a sharp mind at any age? In this program, Dr. Nancy Isenberg discusses the latest science-based practices to promote brain health and resiliency as we age. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40508]

Gordon Saxe, M.D., Ph.D., reveals the secrets to slowing down the aging process and living a healthier life. He uncovers how aging affects everything from our bones and muscles to our brain, leading to issues like memory loss, fatigue, and weakened immune responses. How can you make choices today that could help you live longer and feel better? Saxe dives into groundbreaking research on caloric restriction, a powerful tool for extending lifespan, and how a plant-based diet can prevent chronic diseases and improve overall health. He also shares practical tips on exercise, stress management, and social connection that can help you stay sharp, strong, and energized as you age. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40322]

Anthony Lim, M.D., J.D., explores how small, intentional steps can lead to lasting behavioral change. Lim breaks down a simple, four-step framework—awareness, intention, action, and reflection—to help people achieve their goals, whether it's improving health, forming better habits, or making positive life changes. Through real-life examples and insights from neuroscience, he emphasizes the power of connecting with your deeper "why," taking action, and practicing self-compassion. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40323]

Examine how what we eat and how we live can promote wellness, enhance immunity, combat age-related diseases, and promote longevity. Gordon Saxe, M.D., Ph.D., and Anthony Lim, M.D., J.D., share a timeless perspective, supported by their own research and clinical experience, on how optimal nourishment, purposeful reflection, health movement, and generosity of spirit can improve age-related conditions and slow the aging process. They present evidence-based recommendations for diet and lifestyle, as well as a practical and simple framework to help foster extending healthy aging behavioral changes. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40049]

What's the secret to supporting a sharp mind at any age? In this program, Dr. Nancy Isenberg discusses the latest science-based practices to promote brain health and resiliency as we age. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40073]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Dennis O. Clegg, Ph.D., discusses treatments for age-related macular degeneration (AMD), a condition that causes vision loss. Clegg explains that while patients often report improved vision after receiving implants, objective tests don't always confirm this. He explores the potential differences in patients' responses based on genetics and disease progression. There is also an ongoing challenge in finding the best ways to reduce immune rejection of these treatments. New trials are underway to test implants in earlier stages of the disease, and researchers are looking at different strategies like localized immunosuppression. Additionally, some studies suggest that secretions from retinal cells may help preserve vision. Overall, there are many open questions, but advances in the field offer hope for better AMD treatments. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39459]

The risk for many chronic diseases is directly linked to metabolic changes in the body and loss of muscle mass often associated with aging. In this program, Dr. Natalie Marshall focuses on the central importance of movement, strength training, and body composition to improve metabolic fitness and tips to help you get started “building muscle for life." Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40071]

UC Davis researchers are developing innovative technology ​​to help older adults maintain independence while staying connected with loved ones. The new I-Care platform combines task management tools with advanced sensor technology to address challenges like cognitive decline and social isolation while also reducing caregiver burnout. Watch as our experts improve the future of senior care. Series: "UC Davis News" [Health and Medicine] [Science] [Show ID: 40175]

Colin Depp delves into the critical role of social connections in our well-being, particularly in the context of aging. Depp explores the impacts of digital versus in-person interactions, the influence of cultural differences on social needs, and the potential health benefits of both deep and superficial connections. Depp also discusses the challenges of loneliness, the effects of grief, and offers practical daily practices to strengthen social ties. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39388]

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body's natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on the effects of exercise on brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40062]

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, and discover actionable steps you can take to protect your brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40061]

What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on diet and cognitive decline. Learn how diet, vascular health and inflammation contributes to cognitive function and discover actionable steps you can take to protect your brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40063]

What can you do today to improve or maintain your brain health? Sarah Banks, Ph.D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and corrective tips associated with sleep apnea. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40042]

Maria Rosario (Happy) G. Araneta, Ph.D., M.P.H., highlights the significant impact of prenatal and childhood malnutrition on later health outcomes, including coronary heart disease and diabetes. She emphasizes the importance of physical activity, strength training, and the need for inclusive research to address health disparities. Future research directions include understanding cognitive impairment related to diabetes and developing effective interventions for diverse populations. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39392]

Can we not only live longer but better, healthier lives? Robert A.J. Signer and Shiri Gur-Cohen describe how stem cell research may hold the key to longevity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39869]

Can we not only live longer but better, healthier lives? Robert A.J. Signer and Shiri Gur-Cohen describe how stem cell research may hold the key to longevity. Centenarian Stanley Clothier shares his secrets to a long life and artist Amy Burkman celebrates the connection between art, science, and her own health journey. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39722]

What can you do today to improve or maintain your brain health? Sarah Banks, Ph.D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and offers practical tips for enhancing brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39387]

Benjamin Smarr Ph.D. discusses wearable tech in health research, stressing community engagement in data sharing. He explores sensors tracking temperature, heart rate, and more, noting the importance of naps for health. Smarr addresses reliability, access, and the link between sleep and conditions like dementia. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39853]

Benjamin Smarr Ph.D. discusses wearable tech in health research, stressing community engagement in data sharing. He explores sensors tracking temperature, heart rate, and more, noting the importance of naps for health. Smarr addresses reliability, access, and the link between sleep and conditions like dementia. He mentions ongoing research beyond temperature tracking, emphasizing inclusivity and health factors' consideration. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39386]

Claudia H. Kawas, M.D., addresses Alzheimer's disease and related conditions in older adults, noting the challenge of accurate diagnosis and the resemblance of other brain conditions to Alzheimer's. She introduces "resistance" and "resilience," explaining how some individuals remain cognitively intact despite brain changes. Kawas suggests declining dementia risk due to improved vascular health management, emphasizing the complexity of cognitive decline and the need for further research. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 39532]