Podcasts about ftdp

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Andy and Lucas recap an exciting week 1 in college football. What prospects are gaining stock? What prospects need to shape up? We will let you know! The guys also preview week 2. Listen here to see which prospects you should be watching this week!

Scott Barrett of Fantasy Points joins the FTDP for a second time to go over his latest My Guys article, another look at the 2022 rookie class now that summer is coming to an end, and a discussion on Zero-RB. Join Thomas, Jakob, and Billy for another episode of Full Tilt Fun. --------------------------------------------------- https://discord.gg/3dzgyQnNyU Our Discord is up and running! All the Tilters in a one-stop show for all things football! Get expert analysis, trade advice, your favorite Twitter news, and all the tilting you could possibly want in one convenient location. Subscribe, like, comment, and share! https://www.truenorthffb.com/fulltilt/ --------------------------------------------------- Follow us and all the Tilters on Twitter! @DynastyTilt https://twitter.com/DynastyTilt @ThomasTippleFF https://twitter.com/ThomasTippleFF @BigBillyFF https://twitter.com/BigBillyFF @FF_RTDB https://twitter.com/FF_RTDB

Tom and Tomlie take it back to the original Fantasy Walkabout to discuss how to reconstruct/build your roster with only two weeks left until the regular season. In addition, they discuss what to do if you are a tweener, discuss some ADP decisions, and of course, the trade game.

Lucas and Tom are here to discuss how to trade for and trade away some of the elite players in Fantasy Football! From the like of Johnathan Taylor to Derrick Henry, how are you supposed to look at these players? We are here to help! https://discord.gg/3dzgyQnNyU Our Discord is up and running! This is a one-stop show for all things football! Get expert analysis, trade advice, your favorite Twitter news, and all the tilting you could possibly want in one convenient location. Subscribe, like, comment, and share! https://www.truenorthffb.com/fulltilt/

John and Andy are here to talk about the Big 12 and the ACC as the college season is quickly closing in. They also cover the Pre-Season ALl-Americans and hit you with more over/under. https://discord.gg/3dzgyQnNyU Our Discord is up and running! This is a one stop show for all things football! Get expert analysis, trade advice, your favorite Twitter news, and all the tilting you could possibly want in one convenient location. Subscribe, like, comment, and share! https://www.truenorthffb.com/fulltilt/

Tom is back with Lucas after his bout with Covid to have an honest, casual fantasy football discussion about why it is so important to have diversity in your dynasty rosters. When is it time to worry about your rostership percentages? How do you pivot off of a player you love? Come find out with the FTDP Fantasy Walkabout. --------------------------------------------------- https://discord.gg/3dzgyQnNyU Our Discord is up and running! This is a one-stop show for all things football! Get expert analysis, trade advice, your favorite Twitter news, and all the tilting you could possibly want in one convenient location. Subscribe, like, comment, and share! https://www.truenorthffb.com/fulltilt/ --------------------------------------------------- The Full Tilt Dynasty Podcast and Underdog Fantasy have partnered up! Use the promo code: FULLTILT to get a matched deposit of up to $100. That means free entries into best ball mania! Help us and help yourself!

Returning for another edition of off-season fantasy football talk is none other than Pat Daugherty. Co-host of "A Good Football Show" for NBC Sports Edge and an established writer. Pat will help Tom, Billy, and Jakob go through some players 'ADPs they are actually buying into. Or why they still won't look their way, is it at the expense of the other players on their team? ADP philosophy? Tune in and find out. Along the way, we have an appointment at the Big Bank Of Billy, and the FTDP will have Pat try and guess if Headlines are real or fake in a dive into Pat's long-tenured writing career. Our Discord is up and running! one-stopThis is a one stop show for all things football! Get expert analysis, trade advice, your favorite Twitter news, and all the tilting you could possibly want in one convenient location. https://discord.gg/3dzgyQnNyU Subscribe, like, comment, and share! Follow us and all the Tilters on Twitter! @DynastyTilt https://twitter.com/DynastyTilt @ThomasTippleFF https://twitter.com/ThomasTippleFF @BigBillyFF https://twitter.com/BigBillyFF @FF_RTDB https://twitter.com/FF_RTDB The Full Tilt Dynasty Podcast and Underdog Fantasy have partnered up! Use the promo code: FULLTILT to get a matched deposit of up to $100. That means free entries into best ball mania! Please help us and help yourself!

Thomas, Tom, and Lucas continue the FTDP divisional breakdown with the AFC South. Along the way, they punish a tallie and get into the hard yakka, so you don't have to. Is Matt Ryan due for a good season, considering his ADP? Is Pittman JR being drafted at his ceiling? Are the Titans on the downturn? Derrick Henry on his official decline? All of this and more in this episode. We appreciate every one of you. But it would mean a lot to us if you would head over to YouTube, iTunes, and Spotify and leave a comment and sub it would help us move up the charts. Tell us our shirts are dirty or our hats suck doesn't matter, but it means a lot to us.

With no Billy this week, Lucas steps onto the flagship show to help get Tom and Jakob through an episode without totally derailing the show. In this episode, they will talk about more ambiguous WRs, why there seems to be a gross drop-off at the top, and maybe they will go at it in the court of FTDP opinion in a People V. RTDB.

All three guys are ready to play Billy's new game, "The Big Bank Of Billy." They will go through the big pile of off-season headlines to see if there are any to really care about. Who is in the top 20 who will be sent into the sun by this time next year? The FTDP has that too and more via the True North Fantasy Football Network.

With another Player Profiler alumni hopping on with us, we continue the trend of asking value-defining questions. So why not when we have the running back whisperer hopping on today to discuss some of the post-draft value fallout. Be sure to subscribe to True North Fantasy @ https://www.youtube.com/c/TNFFNetwork. And check out all the FTDP pods at http://www.truenorthffb.com/fulltilt/

After a hectic draft weekend, we saw some of our favorite players come through, and others take a deep dive into sadness. Billy, Tom, and Jakob are back with the first post-draft FTDP. How long will it take for Jakob to mention Wan'Dale Robinson? How fired up is Tom about Cook? Is Billy happy with the updated WR room in Green Bay? All this and more on this edition of the FTDP on the True North Fantasy Football Network.

PART TWO with Scott Barrett to get you through to the draft show. With a unique opportunity to host one of the most creative minds in the fantasy football world. The FTDP is happy to welcome Fantasy Points own Scott Barrett. One day before the draft couldn't be better timed to have the man behind the most in-depth rookie model articles. The guys will get the chance to dive into everything from the beginning of FantasyPoints.com and the Fantasy Points Media Group. For example, what sets Fantasy Points apart from the other fantasy football content providers? They wouldn't let the chance to talk about the 2022 NFL draft. And, of course, it wouldn't be an FTDP if they didn't have more exciting news for you all.

Need Full Tilt Content to get you to the draft show well? We have you covered in this 2 part episode. With a unique opportunity to host one of the most creative minds in the fantasy football world. The FTDP is happy to welcome Fantasy Points own Scott Barrett. One day before the draft couldn't be better timed to have the man behind the most in-depth rookie model articles. The guys will get the chance to dive into everything from the beginning of FantasyPoints.com and the Fantasy Points Media Group. For example, what sets Fantasy Points apart from the other fantasy football content providers? They wouldn't let the chance to talk about the 2022 NFL draft. And, of course, it wouldn't be an FTDP if they didn't have more exciting news for you all.

It is time to finish what we started—the final five of the consensus FTDP rookie countdown. The guys will reflect on the top 20, what they expect from the NFL draft, and some of the hot ticket news the guys are putting together. We may also get a surprise last-second guest towards the show's end is not one you will want to miss. We cannot wait for the April 28th draft show and all the good times and great guests we have in store for you.

We had some connection issues with Jakob, but he was a champ, and we got through it. If you want some top-tier laughs, this is the episode for you. DO NOT MISS THE END. This show goes off the rails quickly and ends on a wild note. Week 2 of the rookie countdown is here. On this show, the guys are counting down picks 15 to 11. Who will the disagreement be about today? Who is going to be way too high? How many times can Jakob tell you to avoid QBs? What does the FTDP have in store with more announcements on the way? Have you entered the Saquan Barkley giveaway yet?

It's here, it's here, it's everyone's favorite time of year. Tom, Billy, and Jakob are here to countdown the FTDP consensus top 20 fantasy rookies. Stats, videos, and bad takes are going to help guide us all the way to the draft. Along the way, in this one, Tom forgets how high he had Howell. Then, Billy and Jakob go toe to toe on Wario Robinson, and Tom finds a way to sneak a Ravens reference in there on David Bell.

The FTDP saved the best for last as we bring in Josh larky, the Director Of Analytics at @RotoUnderworld, PlayerProfiler.com, and BreakoutFinder.com. Recently Josh has been taking his talents to TikTok and blowing up the FYPs of fantasy fans from all over. Never a man to hold back his opinions about best ball and dynasty, we are excited to have him come and talk about living life by the bar graph.

With an insane week, including huge signings and significant trades, Tom and Tom will try and go through them. But, of course, there are tons of value shifts, and the FTDP will try and apply some of the recent knowledge shared by recent guests like Austin Gayle, Ben Gretch, and Pat Daugherty and help you make the best decisions for your teams. Don't forget to use the promo code FULLTILT on Underdog Fantasy as a first-time player to have your money doubled to 100$. Reach out and get yourself into one of the many private tournaments held by us today.

In this 2 hours special episode, the FTDP is happy to have Ben Gretch, the Stealing Signals News Letter, Co-Host of Stealing Bananas, and Ship casting. An expert in zero running back drafting and Anti-Fragility drafting, and so much more. We can't wait to bring a different look at ways to improve your fantasy football season. And don't forget to go to Underdog Fantasy and use promo code FULLTILT to get your first deposit doubled up to 100 dollars. https://play.underdogfantasy.com/p-full-tilt-dynasty

In this Bonus Episode, the FTDP is by the Co-Founder of the Number One source of college fantasy football and devy data sites Campus2Canton.com. First, they will explain why they created Campus2Canton.com and why playing devy makes you a better dynasty player. Then, in a special bonus edition Stat Corner, they put Alfred to the test and more. We can not wait to continue bringing you great guests and providing the great content you have come to expect from the FTDP brand. We love and appreciate you all.

The FTDP is excited to be joined by the Co-host of A Good Football Show for NBCSportsEdge. They take a look into how Pat got to where he is now with NBCSportsEdge, A way to early 2022 preview, and of course, combine reactions. This is a big show for us, and we just wanted to say thank you to everyone who has supported us so far. You are genuinely Tilters.

All of the FTDP guys are in the house to talk process, rookies, and how our drafts are looking right now in the off-season. What are the worst picks of their drafts thus far, and how could they have been avoided with so much more. Also, we will remind people how to win the Barkley giveaway and our announcements for upcoming episodes. As always, we love and appreciate every one. So if you can give us five stars and subscribe to where you get the FTDP, we would be eternally grateful.

In today's episode, the FTDP crew will discuss their process. All three hosts have very different process styles, and for the first time, they will go through them on air. For better or worse, we will hear how the minds of these three lunatics work in fantasy football. Along the way, they talk about players that have forced them to change their process, players we are into because of it, and others they are so wildly out on. Of course, we have Billy's stat corner, a giveaway reminder, and a few guests to announce as well. As always, hit the subscribe button for more FTDP content, including a new show, perhaps?

Tom and Tom are set to go over navigating your tiers when trading. For example, how do you determine when it is ok to drop a tier at RB to move up a tier or two at WR? along the way, they talk about what players are making you throw your hands up because they have hit their in-between values. They go over the Barkley giveaway information again and much more. As always, like and subscribe for more content from the FTDP. We appreciate you all.

The FTDP trio of Jakob, Tom, and Billy are sitting down to discuss the potential quarterback carousel. The Flores bombshell, their way to early offseason predictions, and who will have the most significant value change once the Super Bowl is over. As always, if you enjoyed this show, make sure to subscribe on your podcast player and leave a rating even comment it goes a long way in helping us bring you Full Tilt content.

Tom and Tom are back with the true value-based programming you need to kick off your offseason. This week we bring in FTDP co-host Big Billy to talk through some of the happenings in the NFL so far and how to start attacking narratives this early in the offseason.

Tom and John are back to complain about the covid week and many playoff losses. But what topics drove them crazy this week? Stay tuned to the end for a taste of the FTDP huge giveaway coming up. Happy Holidays to all.

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For week three, Tom and John actually agree..for a few minutes. Tom has something to say about the "I'm right .com" folks. John has a few things to say about veteran running backs. This show is a lot of fun, and everyone with the FTDP family appreciates all of you.

All three FTDP mates are here to look way back into early June at our early flag plants. Did we get any right? Are we so bad we need to stop playing fantasy football? Well, let's have a look at how it started and how it is going.

Billy and Tom are on their b.s as they start with a plan for the show, but they have it go off the rails about 3 minutes in. However, in a more laid-back edition of the FTDP, the boys have a great time looking ahead to this week's slate of games. With no stat corner this week, Billy hits us with some Derrick Henry facts that further prove why he is the ultimate outlier.

All three of the boys are back this week to dive into what happened on Thursday night, another Billy's Stat Corner, new FTDP approved starts for stats this week, and of course, we will be talking about some of our favorite and least favorite trios in fantasy football. So leave a comment and rate five stars as we march further into an entertaining 2021 football season.

In this first edition of the weekly review, Billy takes you on a fast-paced review of all the action leading up to Monday Nights' game before Tom and Tom review it on the WalkaboutSo, get ready to lock in with BigBillyFF on the 4th show brought to you by the FTDP.

Tom and Jakob are here to go through the Thursday night football game banger and get you ready for their best calls for the weekend, and Billy stops by to give his picks from a place unknown all this and more on today's FTDP. We appreciate everyone sticking through the off-season with us, and we can't wait to bring you great information and entertainment.

Tom and Tom are back before the FTDP take a week off but don't fret. They have plenty of information to digest before heading back to help get you set for the regular season. If you missed the FTDP Saturday with Matt Kelly - https://youtu.be/WyoUIrAJtxw If you want a new pod to listen to, our host ThomasTippleFF visited the Brothers Of Dynasty, and the link to that is right here. - https://brothersofdynasty.buzzsprout...

This episode was long, but with no episode, next week. As the guys need a well-earned rest, you will have lots of time to catch up. @Fantasy_Mansion joins us to talk through training camp and give us the hottest takes and hardest truths for the year ahead, with Billys' Stat Corner. a "Mansion V. RTDB, and much more a truly jam-packed show. We could not thank Matt enough and even our own host with the most time on his hands had to shake off some nerves in this true one-of-a-kind edition of the FTDP.

Tom and Tom are back to finish off the positional true value breakdown. Join them for more Aussie slang and insightful trade talk. Then, be sure to head to fulltiltdynasty.com for all things tilt and tune into Saturday's FTDP with The Podfather himself.

This week the guys have decided it is time to do a dynasty mock draft in their very own way. First, of course, they discuss the news of the week the way they always do, and of course, Tom and Jakob try to hand Billy an L in the Stat Corner finally. Go to fulltiltdynasty.com for exclusive FTDP content.

This week Tom and Tom discuss the RB landscape primarily for dynasty rosters that are a couple of years deep. We talk a lot about startup value because it is easiest, but how do you apply that to your leagues with a history? We talk about the Cam Akers news briefly and then refocus on how and when it is ok to overpay for specific actual values. If you haven't, subscribe to Fulltiltdynasty.com for exclusive written content from all the FTDP staff.

This week the host with the most time on his hands and the paragon of objectivity brings you a special edition of the FTDP with Tyler Karp of DLF. Tyler, never one to be shy, fit right in with the boys as they gave passing and failing grades to players, and Tyler even gave Jakob a run for his money in The People V. RTDB, but could he finally take down the FTDP soon to be a lawyer? Can Jakob fill in for Billy in the stat corner? And how can you file an appeal or win a shot to be on the next Fantasy Walkabout to build your own tiers? Find out on this week's episode. Stay safe and have fun.

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Tom and Tom are back to go through the Value Accumulation Project part two and how we approach the Projections/analytics and film when building our tiers. Discuss the new partnership with the @DynastyVipers and, of course, see if Tom can make Tom gasp for air with this week's Aussie slang.

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The Full Tilt Dynasty Podcast Presents - The Fantasy Walkabout In episode one, the newest member of the FTDP enlightens us with his views on rankings and tiers and lays out what the next month looks like for the show under the brand you've come to know and enjoy. Thomas discovers what "Shits me to tears means" and lets you know how to file your appeals for the Pitts TE1 in dynasty verdict from last Friday's show.

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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.17.157552v1?rss=1 Authors: Abreha, M. H., Ojelade, S., Dammer, E. B., McEachin, Z. T., Duong, D. M., Gearing, M., Bassell, G. J., Lah, J. J., Levey, A. I., Shulman, J. M., Seyfried, N. T. Abstract: One of the defining pathological features of Alzheimer's Disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphorylation and toxicity of tau, making the responsible tau-directed kinases attractive therapeutic targets. The full complement of tau interacting kinases in AD brain and their activity in disease remains incompletely defined. Here, immunoaffinity enrichment coupled with mass spectrometry (MS) identified TANK-binding kinase 1 (TBK1) as a tau-interacting partner in human AD cortical brain tissues. We validated this interaction in both human AD and familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) caused by mutations in MAPT (R406W) postmortem brain tissues as well as human cell lines. Further, we document increased TBK1 activity in both AD and FTDP-17 and map the predominant TBK1 phosphorylation sites on tau based on in vitro kinase assays coupled to MS. Lastly, in a Drosophila tauopathy model, activating expression of a conserved TBK1 ortholog triggers tau hyperphosphorylation and enhanced neurodegeneration, whereas knockdown had the reciprocal effect, suppressing tau toxicity. Collectively, our findings suggest that increased TBK1 activity may promote tau hyperphosphorylation and neuronal loss in AD and related tauopathies. Copy rights belong to original authors. Visit the link for more info

Prime Minister Scott Morrison says reforming industrial relations will be one of the keys to Australia's economic recovery. - udwdmfcd.fus>>f puD.frDR&HRp>R tw>frRoDxD.fuhR pJ;zDu[.fw>fzH;w>frR tw>f&hvdmfo; oh.fwz.ftHR urh>f0J'.f w>f*h>fcd.foh.f tgr;tusgwcg v>w>fbSDoDxD.fuhR uD>ftDp-whv,g rk.fusdmf0JRuGmft*D>fe h.fvDR?

Recently, some Karen singers from Myanmar have been touring Australia. The four singers, Saw David Htoo, Naw Dah Eh Poe, Nant Phway Phway San and Saw Gay Nay Moo had participated in a few bushfire fundraising concerts during their music tour. - zJw,HR'fb.fe h.f y0JunD ySRo;0H.fw>fzdweDR [J[;'D; ol.f0H.fo;q>0J'.fzJtDp-whv,guD>fylR w>fvD>ftgwDRe h.fvDR?

Australia is one of the most bushfire-prone lands in the world. With the temperature getting warmer as we're settling into summer, the risk of bushfires is getting higher. So, how do you prepare for bushfires and how do you stay safe? - v>[D.fcd.f'Dbh.ftylR uD>ftDp-whv,g rh>f0J'.fxHuD>fwbh.fv> yS>frh.ftltd.ftguw>>fw>fvD>fwcge h.fvDR?

New visas have been launched this week to encourage zookeepers, architects, scientists, blacksmiths, naturopaths, surgeons and more to settle in regional areas. - wEGHtHR uD>ftDp-whv,gy'd.f p;xD.fymfzsgxD.f0J'.f [D.fu0DR vHmfcDuD>f w>f&J.fw>fusJRtoD v>t[h.f*H>f[h.fbg0J'.f ySRv>tuG>fxGJ q.fzduD>fzd/ ySRohwhxD.fbSDxD.f[H.fCD/ ySRpJth.fzd/ ySRohydmfx;ydmfCJmf/ uoH.fo&.f/ uoH.fo&.fv>tul;uGJ;ySRqgoh.fwz.f'D; ySRv>ttd.f'D;w>fohw>fb.ft*kRt*R 'fod;t0Joh.f uok;qDvDRtd.fqd;0J'.fql [D.fu0DR oh.fwz.f tylRe h.fvDR?

39-years-old Karen refugee Aung Tin was forced to leave his hometown in Karen State of southern Myanmar and sought refuge in the Thai-Burmese border for more than a decade before settling in Australia. -

New data shows Australians are reporting cyber security incidents every 10 minutes and it’s costing Australian businesses $29 billion each year.But what kind of cyber crimes are people falling foul of, and how can someone protect themselves against them? - w>fCdxHoh.fngtoDwcgtylR ymfzsg0J'.f ySRtDp-whv,g xHzduD>fzdoh.fwz.f wD.fzsg0J'.f w>fv>tuJxD.fto;'D; “pJRb>R” w>fbH.fw>fb>oh.fwz.f ud;trH;eH; 10 'J;C.fC.fng'D; w>ftHR ud;eH.f'J;e h.f vDRv>0J'.f ySRtDp-whv,g xHzduD>fzd rk.fusdR0JRuGR phtd.fv> 'D.fv.f 29 bHRv,R e h.fvDR?emfouh “pJRb>R jcJ”= “pJRb>R”w>frRur.foJp; 'fvJ.fwuvkmf v>tb.fySRtguw>>fvJ.f'D; v>w>fvH.ftD.fvDtD.ftHRtylRe h.f eu'Do'>eo;'fvJ.f?

The Karen Buddhist community in Melbourne recently bought a land to build a Karen monastery as the population of the group is growing. - unD bgoDcg v>t[JwkR td.fqd;zJ rJvfb>.f0h>f uD>ftDp-whv,gtylRoh.fwz.f cJtHR &J.fusJR0J'.fv> t0Joh.f uol.fxD.f oDcgzF.f 'D; ySRw0>w>fvD>fwcge h.fvDR?

Asian-Australians are the most likely ethnic group in the country to report experiencing discrimination.That's according to a new study conducted as part of research into the so-called "bamboo ceiling".Researchers hope the survey will spark a rethink on Western notions of leadership and strategies to help workplaces allow Asian employees to excel. - w>fCdxHoh.fng toDwcgtylR ymfzsg0J'.fv> ySRtDp-whv,gzdv> t[JvDRp>RvDRoGJ.fe h>fv> ySRth&S>.fzd v>yud;tDRv> (th&Sg=tDp-whv,g) oh.fwz.f rh>f0J'.f uvkmf'l.fwuvkmf v>twl>fb.f0J'.f w>fuG>fwvDRtDR tguw>>fwzk zJuD>ftDp-whv,gtylRtHRe h.fvDR?

There are several minor offences in Australia that could get you in trouble that you might not know about.And the consequences can be severe. - zJtDp-whv,guD>fylRtHR w>frRur.foJp;w>fbs> qH;ud;zd v>tuJxD.fw>fuDw>fcJv>e*D>foh oh.fwz.f td.f0J'.ftgr; v>ewoh.fngtDR'fb.fe h.fvDR?'D;w>fv>tydmfxGJxD.ftcHoh.fwz.f CH;0Jql.f0J oh0J'.fe h.fvDR?

Are the suits you wear to work every day tax-deductible?It is that time of year again to get your tax affairs in order.So what is the Australian Taxation Office targeting this year? - zJuD>ftDp-whv,gtylR ,lRvH 1 oDwkRv> tD;uxdb>.f toD 30 e h.f rh>f0J w>fq>uwD>fv> w>fymfzsg'D;ChxD.fu'guhR cdoGJ v>w>fxk;ymfCmfftDRoh.fwz.fe h.fvDR/weH.ftHR w>fv> tDp-whv,g cdoGJ0JR'>; uorHord;uG>ftDRoh.fwz.f rh>fw>frEkmfvJ.f?

‘Tax time’ is when Australians complete their tax returns after the end of the financial year on 1 July. It’s the time to check if the correct amount of tax has been paid and if any deductions can be claimed. It can also mean money back in your pocket in a tax refund. - zJuD>ftDp-whv,gtylRtHR w>fymfyeD.f0J'.f usd.fpheH.fuw>>f v>weH.ftwD>fylRrh>f0J'.fzJ vg,lRvHwoDteHRe h.fvDR? zJe h>f0HRtvD>fcH w>frRySJR0J'.f w>fzH;w>frR'D; usd.fph t*h>ftusdR v>w>fymfzsg'D; w>fChxD.fu'guhR cdoGJt*D>fe h.fvDR?

There are a few important issues to consider for new migrants before starting work in Australia, from applying for a job to paying tax.A Tax File Number is the one, unique link, which connects all your earnings, superannuation and taxation. - y0JunDzdweDR yuoh.fng b.fC;w>fChxD.f cdoGJeD.f*H>f emfouh weDRvDRqD'.fw>f ySRv>[JwkRtd.fqd;oD zJuD>ftDp-whv,gtylRoh.fwz.f woh.fng0J'.f w>ftusdRtusJ v>w>fChxd.f cdoGJeD.f*H>f'fb.fe h.fvDR? ySR[Jok;vD>ftd.fqd;oD zJuD>ftDp-whv,gtylRoh.fwz.f wcsK;'fv> t0Joh.fp;xD.f zH;w>frRw>f zJuD>ftDp-whv,gtylR'fb.fe h.f w>ft&h'd.fv> t0Joh.f ub.foh.fng td.f0J'.f pSRud;xH.fe h.fvDR? w>foh.fwz.fe h.f rh>f0J'.f w>fCkw>fzH;w>frR'D; w>f[h.fw>fcdw>foGJe h.fvDR?

Every year, thousands of refugees and asylum seekers arrive in Australia. They are often fleeing war, persecution and torture. Making sure they can access healthcare, including mental health services, is an important part of their settlement. But the Australian healthcare system can bring new challenges for them. - ud;eH.f'J;e h.f ySRb.fuDb.fcJ'D; ySRChvD>ftd.fu'k v>tuxdtgr; [JwkR0J'.fzJ uD>ftDp-whv,gtylRtHRe h.fvDR? t0Joh.fwz.f tgwuh>f rh>fySRv> tb.fCh>fylRzsJ;to;v> w>f'k;w>f,R/ w>frRql.frRqD;'D; w>frR'>.frRe>Re h.fvDR? w>f'd;e h>fb.f ql.fcs hw>fuG>fxGJ v>ty.fCkmf'D; eD>fo;ql.fcs h*h>f0De h.f rh>f0J'.f w>ft&hwcg v>t0Joh.f w>fol.fvDRtd.fqd; t*D>fe h.fvDR? emfouh tDp-whv,g ql.fcs h oEl uJxD.f0J'.f w>fwmftoD'D;t0Joh.f oh0J'.fe h.fvDR?

When Pot Tun Klay first arrived in Bendigo city, Victoria of Australia, she couldn't speak English and found it hard to go around the city. - w>fok;vD>ftd.fqd;ql w>fvD>fwwDRb.fwwDR xHuD>fwbh.fb.fwbh.f 'D; ol.fxD.fw>ftd.frlv>toDe h.f wrh>fw>fv>tnDuJ.fqd;b.f? vDRqD'.fw>f zJyok;vD>ftd.fqd;ql xHuD>ft*Rwbh.f v>tw>fuwdRusdmf/ vk>fv>fqJ;vR'D; w>ftd.frltusdRtusJoh.fwz.f wvDR*mfb.ftcg w>fwmfw>ftd.f0J'.f tgr;e h.fvDR? w>fwmfw>f rh>ftd.ftgr;emfouh unDrk.fzd egzD.fxd.fcs h v>t[Jok;vD>f td.fqd;zJ uD>ftDp-whv,gtylRw*R vJRcDzsd0J'.f wqDwqDwkRv> t'd;e h>fb.f0J'.f w>fzH;w>frR wcge h.fvDR? t0JuJxD.f0J'.f ql.fcs hySRrRp>Rw>fzd 'ftrh>f ySRrRp>R uoH.fo&.f v>t,gbsgrJw>fqg oh.fwz.fe h.fvDR? 'fod;t0Ju'd;e h.fb.f w>fzH;w>ftrRtHRt*D>f t0Jb.fvJRcDzsdw>frEkRoh.fwz.fvJ.ft*h>fe h.f tJ.fpfbH;tJ.fpf unDusdmf qJ;usdmfoHuG>f0J'.ftDRtcg t0Jp;xD.f&SJyF;0J'.f 'ftHRe h.ftDR?

Every year Australian celebrates National Volunteer Week (NVW) from May the 20th to the 26th. This year the theme is "Making a world of difference". During the National Volunteer Week, SBS Karen Program spoke to a former Karen refugee Naw E'mer Paw, who is a volunteer at Multilink in Brisbane. E'mer Paw San Shwe, the Inspirational Women Award 2012 recipient explained why she loves to be a volunteer. - tDp-whv,guD>fylRtHR vgrhR toD 20 wkRvDRv> 26 oDteHRe h.f w>fymfyeD.f0J'.fv>trh>f 'Duvkmf ySRrkmfo;rRuvDw>fzd tEGHe h.fvDR? tDp-whv,guD>fylRtHR ySRrkmfo;rRuvDw>fzdtd.f0J'.f t*R 6 uuGJ>fe h.fvDR? ySRrkmfo;rRuvDw>fzdoh.fwz.f rh>f0J'.f ySRv> t[Je h.fv> uvkmftgrHRuvkmf qJ;vRtgrHtgrFd v>ty.fCkmfph>fuD;0J'.f unDzd v>t[JwkRtd.fqd;zJ uD>ftDp-whv,gtylRoh.fwz.fe h.fvDR? zJ'DuvkmfySRrkmfo;rRuvDw>fzdtEGHtHR tJ.fpfbH;tJ.fpf unDusdmf qJ;usd;oHuG>f0J'.f eD>ftH.fr>RzDq.f&G h.f v>trh>f ySRv>t[h.fvDRtw>fq>uwD>f rkmfo;rRuvD0J'.fw>f zJySRw0>v>t0Jtd.fqd;tylRe h.fvDR? tcJtHR t0Jtd.fqd;0J'.fzJ 0h.f-bH.fpbJ v>ttd.fzJ cGHpvJ uD>fpJ.ftylRe h.fvDR? cDzsdv> w>f[h.fvDRo;v> ySRw0>tylR'D; rkmfo;rRuvDw>fv> ySRw0>t*D>ftCd zJ 2012 eH.fe h.f eD>tH.fr>RzDq.f&G h.f 'd;e h>fb.f0J'.f cd.fz;wcgph>fuD;e h.fvDR? b.fC;'D; t0Jw>frkmfo;rRuvD w>fzH;w>frRt*h>fe h.f t0J&SJyF;0J'.f 'ftHRe h.fvDR?

The 2019 Australian federal election is just around the corner when we will elect members of the 46th Parliament of Australia.So how do elections determine our next government? - zJvgrhR 18oDteHRe h.f w>furR0J'.f 2019 tDp-whv,guD>fp>zSd.f w>fCkx>vDR? zJw>fCkx>tHRe h.f yub.f Ckx>xD.f0J'.f bsD.f'd.fc>.fp;oh.fwz.f v>tDp-whv,gbsD.f'd.f 46 0Dw0D t*D>fe h.fvDR?w>fCkx>tHR rh>ftuq>wJmfe h>f yp>RoGJ.fv>cgqlngwpdR t*D>f'fvJ.f?

To mark the 34th anniversary of the Karen women organization, which falls on the 5th of April, the Karen community in Melbourne and Sydney held a ceremony today. - zJweH.ftHR vgthjzh.f 5oD unDydmfrk.fu&> rk>feHRySJRxD.f 34 0Dw0DteHRe h.f unDydmfrk.fu&> u&>cd.f uGJrkmfb.f0J'.f unDydmfrk.f v>ttd.fv> uD>fylRuD>fcs> xHq>uD>fq> ud;*R uzD.fvdmfpkrR oud;w>f qD.fxGJrRp>Roud; ydmfrk.fu&>tw>f[l;w>f*JRoh.fwz.fe h.fvDR?zJunDydmfrk.fu&>rk>feHR ySJRxD.f 34 0Dw0D tvHmf[h.f,k>ftylRe h.f u&>cd.f y'd.f eD>fzD'hwd q>rk>fv>f0J'.fv> unDydmfrk.foh.fwz.f uq>x>.f*>>fus>Rv> unDydmfrk.fu&>tusJtoEl 'D;zD.fvdmfpkrRoud;w>fwkRv> w>frRe>RtzDw>.fwpke h.fvDR?vgthjzh.f 5 oDteHRe h.f rh>f0J'.f unDydmfrk.fu&>trk>feHRtCd unDydmfrk.fu&>'D; unDzdv>uD>fylR uD>fcs>oh.fwz.f oh.feD.frRvRuyDR0J'.frk>feHRtHRtusg unDzdv> t[Jtd.fqd;zJ uD>ftDp-whv,gylR oh.fwz.fph>fuD; rRvRuyDR0J'.f rk>feHRtHRph>fuD;e h.fvDR?unDzdv>ttd.fzJ 0h>frJvfbd'D; qh.f'eH.f 0h>foh.fwz.f cDzsdv> w>fq>uwD>f w>ftd.fo;tzDcd.ftCd rRvRuyDR0J'.frk>feHRtHR zJvgthjz h.f 6 oDteHRe h.fvDR?

The 2019 federal budget will have an impact on refugee communities in Australia. - 2019 y'd.fphwdmf u'db.frR[l;0J'.f ySRb.fuDb.fcJ tySRw0>v>ttd.fzJ uD>ftDp-whv,g tylRoh.fwz.ftHRe h.fvDR?

Finding a job is a priority for migrants moving to Australia. But most workers need to be able to speak and write English well. Migrants can access free English classes to learn the basics of English or to improve their language skills to get a job. - zJeok;vD>ftd.fqd; zJtDp-whv,gvHe h.f v>w>fCkzH;CkrR'D; w>fuqJ;usd;od;o;'D; ySRw0>oh.fwz.ft*D>f w>frRvd tJuvH;usdmf rh>f0J'.f w>fwrHRv> tvD>ftd.fv>w>fub.frRvd0J'.f tDRe h.fvDR?

While a majority of Australians say that they are willing to donate organs and tissues after their death, not all of them have taken the steps to make it happen. Dr Helen Opdam, the national medical director at the Organ and Tissue Authority, says becoming a donor is easy. - zJeoHtq>uwD>f erh>frRyl.fvDR uh>f*DR'GJ'D; xH;&SLe h.f tpSRuw>>f erRp>Rb.f ySRw>ftd.frl e h>fwkR0J'.fv> t*RwqHnge h.f rh>feoh.fngph>f{g? ySRtDp-whv,gzd v>txdtgr; td.fcd;0J'.fv> turRySJRxD.fuhR t0Joh.f uh>f*DR'GJoh.fwz.ftCd t&h'd.fv> ySRunDoh.fwz.f uuJxD.fySRv> turRbl.fvDR uh>f*DR'GJ oh.fwz.fe h.fvDR?

When parents are involved in their children's school and education, it has positive effects on their grades, their attendance and their well-being in general.But parents new to Australia might not always know where to start. - zJrd>fy>foh.fwz.f EkmfvDRy.fCkmf rRoud;w>fv> t0Joh.f tzdoh.fwz.f tuFd'D; tw>frRvdrR'd; w>ful.fb.ful.fohtylRe h.f uJxD.f0J'.f w>fwkRxD.fxD.fb;v>t*hR v>zdoh.fwz.f tw>fxD.fuFd w>frRvHmf tywD>f'D; w>ftd.fql.ftd.fcs ht*D>fe h.fvDR?emfouh rd>fy>fv> t[JwkRoDzJ uD>ftDp-whv,gtylRoh.fwz.f ub.f p;xD.frR0J'.f 'fvJ.fe h.f b.foh.foh.f woh.fng0J'.fb.f?

It's important for migrants, just like any other Australian, to learn what rights they have as a worker in Australia and how to report exploitation. - 'ftDp-whv,g xHzduD>fzdoh.fwz.ftod; ySRv>t[Jok;vD>ftd.fqd; zJuD>ftDp-whv,gtylRoh.fwz.fph>fuD; zJt0Joh.f EkmfvDRrRw>fzH;w>frRtcg w>frh>f [H;w>fcGJ;w>f,mf w>fbsK;w>fzSd.fv>t0Joh.ftzDcd.fe h.f 'fySRrRw>fzdw*Rtod; t0Joh.f ub.fwD.fzsgxD.f0J'.f'fvJ.fe h.f b.fCkoh.fng 0J'.f t0Joh.ftw>fcGJ;w>f,mf oh.fwz.fe h.fvDR?

International students looking to study at Australian universities may face higher English language entry requirements after a push from Victorian Premier Daniel Andrews.He's urging the federal government to lift entry standards for people trying to obtain a student visa, with concerns that many are given places to study but have little likelihood of graduating because of their limited English. - cDzsdv> 0H;xd&H,g uD>fpJ.f udwdmfcd.fus>>f 'Je,>.f tJ;'&l tw>fqD.fxGJtCd xH*kRuD>f*RuFdzd v>t[JxD.fuFdzJ uD>ftDp-wh,g tylRoh.fwz.f ub.fuG>fq>.frJmfb.f0J'.f'D; w>forHord; tJuvH;usdmftywD>f v>txD'd.fxD.ftCd w>fuDw>fcJ utd.fxD.f0J'.fv> t0Joh.f uEkmfvDR td.fb.fuFdt*D>fe h.fvDR?v>w>fuEkmfvDRxD.fb.fuFdzJ uD>ftDp-whv,gtylRt*D>f nDEk>fe h.f w>forHord;uG>f0J'.f w>foh tJuvH;usdmf twDRywD>f rhwrh>f b.f'd;pJ;0J'.f tJ;uvH;usdmfe h.fvDR? rh>fwkRxD.fxD.fb; 'fod;w>fymfyeD.ftDRtod;r; EkmfvDRxD.fb.f0J'.fuFde h.fvDR?

Enticing international students to Australia is big business. According to the Australian Bureau of Statistics, education is our third largest export industry- in 2015 international students contributing over 19 billion dollars to the economy. Australia is renowned for its flexible visas which allow overseas students to work during their studies. But a recent high profile scandal has brought the vulnerability of these students to light. - xH*kRuD>f*RuFdzd tw>f[JEkmfvDRql uD>ftDp-whv,gtylRtHR rh>f0J'.f rk.fusdR0JRuGmf z;'d.fwcge h.fvDR? zJtDp-whv,g y'd.fp&D0JRusdRcd.foh.ftylR ymfzsg0J'.f w>ful.fb.ful.fohe h.f rh>f0J'.f w>fqS>[;xD.f yeHmfw>fuR w>fzH;w>frR t'd.fuw>>fo>rHRwrHRe h.fvDR? cDzsdv> xH*kRuD>f*RuFdzd w>f[JEkmfql uD>ftDp-wh v,g tylRtCd zJtylRuGHmf 2015 eH.fe h.f rk.fusdR0JRuGmf tphw>f[JEkmf td.f0J'.f 'D.fv.f 19 bH;vH;,.fe h.fvDR? tDp-whv,gtHR trHR[lo.fzsg0J'.fv> t[h.f0J'.f w>fqDwvJ vHmfcDuD>f v>w>ftd.fo;tzDcd.foh v>t[h.f0J'.f uD>fcs>uFdzdoh.fwz.f rRw>fzH;w>frRoh zJv>t0Joh.f xD.fuFdzJuD>ftDp-whv,gylR tq>uwD>fe h.fvDR? emfouh w>fCdxHoh.fngxH.fb.f0J'.fv> xH*kRuD>f*RuFdzdoh.fwz.ftHR b.fw>f[H;bsK;[H;zSd.f rRe>RtD.f0J'.ft0Joh.f v>t0Joh.fw>fzH;w>frRtylR e h.fvDR?

For a young migrant, an apprenticeship is a great way to get a head start in a chosen career in Australia. An apprenticeship combines time at paid work with training and can be completed full-time, part-time or while still at school. - ySRo;p>fv> t[Jok;vD>f td.fqd;oD oh.fwz.ft*D>fe h.f w>frRvdoho;v>w>fzH;w>frRtHR rh>f0J'.f usJv>t*hRwbd v>t0Joh.fup;xD.f0J'.f w>fvk>ftD.fo;orl zJuD>ftDp-whv,g tylRtHRe h.fvDR?

With another scorching summer approaching, authorities are pleading with swimmers to use caution as the number of people drowning has jumped by ten per cent since last year. - zJuD>ftDp-whv,gtylRtHR yD.fvJ.fu>>feHRtd.f tge h>f'f0J'.fwuv;'D; zJw>fud>fcgtq>uwD>fe h.f uJ0J'.fw>fvD>fv>trkmfv> ySRvJRvdmfuGJxHoh.fwz.ft*D>fe h.fvDR? emfouh ySRv>t[JwkRoDzJ uD>ftDp-whv,gtylRoh.fwz.f woh.fng yvD>fb.fto;v> w>fb.f,d.fb.fbSDv> tuJxD.fto;ohzJ yD.fvJ.fu>>feHR oh.fwz.f tHRb.fe h.fvDR? tCde h.f zJyvd.fuGJxHtcg 'fod;w>fylRzsJ;utd.f'DySRt*D>f yurRtDR'ftvJ.f?

Neuere Studien zeigen, dass Fehlregulationen alternativer Spleißprozesse erheblichen Einfluss auf die Entstehung von Krankheiten besitzen können. Exon 10 des Tau-Gens wird alternativ gespleißt und je nachdem, ob das Exon ein- oder ausgeschlossen wird, werden Isoformen mit drei (Tau -Exon 10) bzw. vier (Tau +Exon 10) Mikrotubuli-Bindungsmotiven generiert. Bei der Frontotemporalen Demenz mit Parkinsonismus gekoppelt an Chromosom 17 (FTDP-17) führen bestimmte Spleißmutationen zur Retention von Exon 10. Wie die FTDP-17 gehört auch die Alzheimer-Erkrankung zu den sog. Tauopathien, einer Gruppe von Krankheiten, die durch übermäßige Ablagerungen des Tau-Proteins im Gehirn charakterisiert sind. Im Rahmen dieser Arbeit wurde an humanem post mortem Gewebe untersucht, ob der Alzheimer-Erkrankung ein Fehler im Regulationsmechanismus des alternativen Spleißens zugrunde liegt. Mittels RT-PCR und Western Blot wurde das Spleißmuster von Tau Exon 10, dem humanen Transformer2-beta (Htra2-ß) und der CDC-ähnlichen Kinase2 (Clk2) untersucht. Ebenso wie Tau Exon 10 werden auch Htra2-ß und Clk2 alternativ gespleißt, wodurch Isoformen mit unterschiedlichen Funktionen entstehen können. Auf mRNA-Ebene konnte gezeigt werden, dass es im präfrontalen und temporalen Kortex der Alzheimer-Gehirne im Vergleich zu Kontrollhirnen zu einer signifikant stärkeren Expression der Isoform tau +Exon10 kommt. Ein möglicher Mechanismus könnte die Regulation des in Zellkulturexperimenten beobachteten Einflusses von hTRA2-ß auf das alternative Spleißen von Tau Exon 10 sein. Die im Temporalkortex der Alzheimer-Patienten verstärkt exprimierte Isoform htra2-ß1 unterstützt diese Befunde. Ebenfalls aus Zellkulturexperimenten ist bekannt, dass CLK2 sowohl das alternative Spleißen von Htra2-ß wie auch wahrscheinlich indirekt das von Tau Exon 10 beeinflusst. Untersuchungen zur RNA-Expression von clk2 ergaben, dass die phosphorylierungsaktive Isoform clk2 +Exon 4 in allen untersuchten Regionen bei Alzheimer-Patienten im Vergleich zu Kontrollen signifikant vermindert exprimiert wird. Dies deutet auf ein Zusammenspiel zwischen Clk2, Htra2-ß und dem alternativen Spleißen von Tau Exon 10 hin, sodass man sowohl von Htra2-ß wie auch Clk2 einen Einfluss auf die Regulation des alternativen Spleißens von Tau Exon 10 annehmen könnte. Basierend auf Forschungsergebnissen zum Einfluss von Phosphatase-Inhibitoren auf alternatives Spleißen in der spinalen Muskelatrophie (SMA), ist es denkbar, mittels spezifischer Phosphatase-Inhibitoren Einfluss auf die Fehlregulation des alternativen Spleißens von Tau Exon 10 zu nehmen. So könnten beispielsweise Phosphatase-Inhibitoren gegen htra2-ß1 eine verstärkte Phosphorylierung dieses Proteins bewirken und somit den Ausschluss von Tau Exon 10 verstärken. Dieser Mechanismus könnte für die Etablierung eines neuen Therapieansatzes herangezogen werden.

Tau ist ein Mikrotubuli- assoziiertes Protein, dessen Expression im Nervensystem des Menschen der Regulation durch alternatives Spleißen unterliegt. Das Exon 10 dieses Gens, welches für einen Teil der Mikrotutuli- bindenden Domäne kodiert, ist ein für Erwachsene spezifisches Kassettenexon. Mutationen, die den Einschluss von Exon 10 verstärken, resultieren in der Produktion von Tau- Protein, das vier Mikrotubuli- bindende Aminosäuresequenzwiederholungen enthält. Diese Mutationen scheinen in ursächlichem Zusammenhang mit der Frontotemporalen Demenz mit Parkinsonismus gekoppelt an Chromosom 17 (FTDP- 17) zu stehen. In dieser Arbeit konnte mittels Transfektionsexperimenten gezeigt werden, dass die Verwendung von Exon 10 durch ein komplexes Zusammenspiel der CDC- ähnlichen Kinase Clk2, einer SR- Proteinkinase, und des SR- ähnlichen Proteins humaner Transformer 2- b (Htra2- b) reguliert wird. Kotransfektionsexperimente legen den Schluss nahe, dass diese Regulation über mehrere ineinandergreifende Prozesse abläuft. Die Kinase Clk2 scheint dabei sowohl direkt durch Posphorylierung bzw. Hyperphosophorylierung von Htra2- b als auch indirekt durch Einfluss auf die alternative Expression der Htra2- b Isoformen in den Regulationsmechanismus einzugreifen. Phosphorylierung von SR- Proteinen führt zu deren Freisetzung aus den nukleären Speicherkomponenten, den speckles, und damit zur Aktivierung der Spleißreaktion, während sowohl eine Hyper- als auch eine Hypophosphorylierung in der Regel einen hemmenden Einfluss auf Spleißen ausüben. Kontrollierte Phosphorylierung scheint demnach zu einer regulierbaren Veränderung von prä- mRNA- Prozessierungswegen zu führen. Eine Interpretation dieser Resultate könnte als Grundlage für die Entwicklung neuer therapeutischer Konzepte verwendet werden.