Podcasts about sle

From Pain to Wellness in PsA  IL-2 Therapy in SLE? Maybe  Sexual Function in axSpA  "Fact or Fiction: Trinetics Research at ACR"  CD1/BCMA Dual Targeting: One too many targets in SLE  Hydroxychloroquine Blood Levels  The Great Debate: AI in Rheumatology  Coping Strategies in axSpA  "What to do After First TNR Failure in axSpA" 

NSAID Addition Helps the Spine but not the Hips  Durability and Safety of Bimekizumab  Progressive BiTE in SLE 2  Hydroxychloroquine Reduces Autoantibody Levels  When the Back Hurts: uncovering BASDAI drivers in PsA  The Upper Hand in PsA? Not the Dominant One  Airway Disease in GPA  Wired for Success: Vagal Nerve Therapy in RA  GLP-1 in Knee Osteoarthritis  Disparities in Physical Function in SLE 

Impfstrategien bei rheumatologischen Patient*innen Menschen mit rheumatologischen Erkrankungen haben ein erhöhtes Risiko für eine Gürtelrose. Warum das so ist und wie dem Risiko begegnet werden kann, das erfahren Sie in der aktuellen Folge der Podcast-Serie „O-Ton Allgemeinmedizin Extra“ mit Prof. Dr. Klaus Krüger, niedergelassener Rheumatologe in München. Aktive Erkrankung und einige Therapieoptionen erhöhen das Risiko Menschen mit aktiven entzündlichen rheumatischen Erkrankungen wie rheumatoider Arthritis, Psoriasis-Arthritis oder systemischem Lupus erythematodes (SLE) haben ein erhöhtes Risiko für Herpes zoster. Aber auch Therapeutika wie z.B. Glukokortikoide oder JAK-Inhibitoren können das Herpes-zoster-Risiko der Betroffenen erhöhen. Und: Kommt es beispielsweise unter Biologika zu einer Gürtelrose, verläuft diese oft schwer und hat eine erhöhte Komplikationsrate. Es gibt also genügend Gründe für eine effektive Prävention. Das sagt die STIKO Die Ständige Impfkommission (STIKO) empfiehlt eine Impfung gegen Herpes zoster generell für alle Menschen ab 60 Jahren. Personen mit einem chronischen Leiden wie z. B. einer rheumatolgischen Erkrankung sollen bereits ab 50 Jahren geimpft werden. In diesen Fällen wird die Impfung regelhaft durch die Kostenträger übernommen. Eine Sondersituation gibt es bei Patient*innen mit SLE, da diese bereits im Alter von 20 bis 30 Jahren erkranken. Krüger rät auch diese Patient*innen gegen Gürtelrose zu impfen und dafür die Kostenübernahme bei der jeweiligen Krankenkasse zu beantragen. Der Totimpfstoff ist anhaltend wirksam und hat ein gutes Sicherheitsprofil. Diese Podcast-Episode ist mit freundlicher Unterstützung von GSK entstanden. Zur Folgen-Übersicht: https://bit.ly/4hoYfbK

Top 10 des PIRE FLOPS auto de 2025

In this episode of the IC-DISC Show, I sit down with Randy from Trinity Bay Capital to talk about how specialized capital advisory bridges the gap between growing companies and the financing they actually need. Randy spent 17 years in traditional banking at First City and other institutions before moving into capital finance in the mid-1990s. His transition came from frustration with banking silos that prevented common-sense solutions for growing companies. After traveling extensively as a capital finance professional and later serving as president of a bank, he launched Trinity Bay Capital to help companies access everything from asset-based lending to purchase order financing. His approach differs from typical brokers because he pre-qualifies deals using his banking expertise, then targets just three carefully selected lenders rather than shotgunning dozens of institutions. What makes Randy's work compelling is how often he solves problems without charging fees. One client I referred received three competitive term sheets that gave him leverage to renegotiate with his existing bank, getting everything he wanted at no cost. Randy's focus on matching companies with conventional banks whenever possible, even when capital finance would pay higher fees, demonstrates how his business model prioritizes client outcomes over transaction volume. His internal 48-page reference guide of specialized lenders reflects decades of relationship-building across oil and gas, maritime, manufacturing, and distribution sectors. Randy's philosophy that "I don't need to work, I do this because I enjoy it" explains why 75% of his pipeline comes from Texas energy companies that conventional banks won't touch, and why he celebrates when clients find better deals elsewhere.     SHOW HIGHLIGHTS Randy turns down fund management opportunities that would pay more because accepting them would recreate the banking silos he left to escape. Trinity Bay Capital targets just three carefully selected lenders per deal instead of shotgunning 12-20 institutions, achieving 95% term sheet success rates. A construction mat company couldn't get financing because their primary assets wear out quickly, until Randy found lenders who advance directly on depreciating equipment. Randy helped a frack pipe manufacturer secure $30 million after eight conventional banks declined, simply by knowing which bank was allowed to do oil and gas deals. One client found a better deal independently, and Randy celebrated it instead of pushing his commission, telling him "as long as I can work with you, that's awesome." Randy's success fee from conventional banks is often reduced compared to capital finance companies, but he always takes clients there first because it's what they deserve.   Contact Details LinkedIn - Randy Gartz (https://www.linkedin.com/in/randygartz/) LINKSShow Notes Be a Guest About IC-DISC Alliance Randy GartzAbout Randy TRANSCRIPT (AI transcript provided as supporting material and may contain errors) Dave: Good morning, Randy. How are we today? Randy: We're doing great. How are you? Dave: I am doing great. Thank you. Where are you calling in from today? What part of the world are you in? Randy: Houston, Texas. Dave: Okay. Me as well. So I was just trying to think, how long have I known you? I think it's been over 20 years. Randy: It's been since the mid nineties. Dave: Has it been that long? Wow. So more like 30 years. Randy: Yes. Dave: We're getting old, my friend. Hey, I look a lot older than you did. That's subjective. So I've got some questions for you. Some I think I know the answer to, some I don't. Why don't we start? I'm a sequential learner. Let's start at the beginning. Where are you from originally? Are you from Southeast Texas? Originally? Randy: I'm an Air Force brat and I was born in El Paso, Texas. Dave: Okay. Randy: And we moved about every two years after that until I was in high school. Well, actually in high school I was at three different locations. And then starting from college on Texas a and an, I've been in Houston ever since. Dave: Why did I forget that you're in Aggie? Because where I went to school and I guess we've been able to get past that. Randy: I don't talk about that much. It's probably one of the main reasons a and m was good to me, but in my past. Dave: Yeah, no, I hear you. I'm just having fun with you. So I suppose moving every two years, that will help you learn rapport, building interpersonal skills, I suppose. Randy: Absolutely. That helped me go to city to city when I was traveling for capital finance companies and just introduce myself about a problem and just, hi, how are you? Who are you? What do you do? So yes, absolutely. Dave: So your degree from Texas a and m? Finance. Randy: Finance. And then I went to U of H and worked on an accounting degree. Dave: Okay. So what was your first job out of college? Randy: Oh, it was at credit training program for First City and Texas. Dave: Oh wow. They really had a great training program, didn't they? Randy: Two years long. Yeah, absolutely. We were working sometimes seven days a week and Saturday and Sunday the air conditioner wasn't working, wasn't on in building. And it's enough like it is today. Dave: No, I remember when I was at Arthur Anderson working one of our clients' weekends, those high rises had air conditioning on the weekends. You had to pay for it and we were not, were deemed worthy of air conditioning on the weekends. Randy: That's right. That's right. Dave: So you started out at traditional banking, Randy: Started at traditional banking, did that for about 17 years. First City and all of its precursors. First city in bank. Bank one, they finally sold to Chase. And then right after they sold to Chase, my manager at the time had gone to a capital finance company and he asked me to follow 'em. And that's when I got involved with Capital Finance. That was back in mid nineties. I enjoyed it. I enjoyed being on help companies. It wasn't like you're in silos at banks and the regulators can only allow you to do so much that there's so much more out there for companies to be able to provide them with growth capital, turnaround capital, acquisition capital that most people, most CFOs don't even know. And so I really enjoy that. I went back to conventional banking when I'm woman by the name of Mary Bass and I think you might know her. Dave: I know Mary. Yeah. Randy: She followed me for two years trying to get me to go to Redstone. Randy: Redstone was a small little bank. I didn't want to have anything to do with it. I didn't want to go to back to banking after I'd gone to Capital Finance and after two years of her calling me every two, three days a week when I was traveling three and a half weeks out of every month for four years Earth saying stuff like, rainy, where are you? When's the last time you saw your son pitch? When's the best time you were with your wife? What'd she do tonight? It's like, Mary, I'll interview. I've got to know that if I say no to this interview, you're not going to call me anymore. Well, I went on an interview, I met with David Chin Decker and he got me to go back to conventional finance and it was a good thing at the time, both he and Bob Hendrickson, who was president at the time of Redstone, had both grown up in the national division of First City's asset-based lending. Dave: That's Randy: What they were trying to bring over to this very small bank. We grew that bank from 58 million to 1,000,000,002 in three years. Dave: That is serious growth Randy: And most of those customers are still there. So it worked. But when you go on to other banks and all the silos that they have, you can't grow. You can't help companies as much as you would like if you know what's available. And I don't mean that to be mean to conventional bankers. Conventional bankers, I have all their respect or I respect them tremendously, but I just think that don't know what's still available. So Dave: It's Randy: Right going out there and trying to educate them to know, Hey listen, if you can't do this, here's what we can do. Dave: Yeah, no, I get it. And I know that as is typical in the banking business, most bankers don't serve at one bank for 40 years. There's always movement. And what I'd like to do though now is I'd like to skip forward to your May gig. I mean, I think the bottom line takeaway was your career was split between traditional corporate lending from the banker level all the way up to senior executive level. You've done the capital finance piece. It sounds like you wanted to create a new combination, new offering to the marketplace. So talk to me about what prompted you to start Trinity Bay Capital. Randy: I think, and I won't name his name, but I had just come back one day from booking an $85 million deal. I was by myself. I was doing all the settlement work. I was there for eight hours at this closing. And when I came back to the bank with all the paperwork and I walked in and I was really happy we got a large deal done, which eventually turned into a much larger deal. The first words out of my president's mouth was, Randy, any more deposits well understand. But this was a pretty good deal. And that together with all the silos that conventional banks have, the inability to do things that should be done, common sense things, but just conventional banks can do because of the regulators and because you can't put a hundred bankers out there and just let them be run out there and do everything they want to do. You can't do that makes conventional bankers conventional. But after being an capital financed group and also being at Redstone's Mezzanine and Equity Group, it taught me all the additional options that we have out there to be able to provide. So I thought at the time I was 63 years old, do I want to go to another bank? Am I tired of these silos? Yes, I am. I decided to just start my own company. I've been asked to take on funds and be able to lend our own money, but that would put me right back in the silos. Dave: Sure. Randy: I just enjoyed helping companies. It just makes me happy. And I wake up every morning, I come upstairs to my third floor office overlooking the bay and no silos, no having to sell every little credit card option that's out there. It just makes me happy. And so I know David, I don't know what I'd do if I retired. I never even considered it. I am enjoying what I'm doing now. I'm happy where I'm at and I'm happy making people happy. Dave: That is awesome. So help me understand who's like your ideal customer? What are the characteristics of the person you can help the most Randy: Fast growing companies, I mean, when you think of me as a broker, which I hate the term, there's 55,000 brokers out there. I trust five. Understood the difference. Lemme first start with the difference. The difference is that I've run credit departments, I've been on credit committees, I've been ping a bank. I know what banks can do and what they can't do. So when a bank can't do something, that is who should come to me, Dave: That Randy: Is who the banker should send me to. And it's not just because it's turnaround, it's not because they're in trouble. Maybe they're growing too fast, the lines of credit are going to be diminished, convince somebody just can't liven to leverage themselves up to the extent they need to take on the growth that they're seeing, acquisition growth where they're going to have to leverage your company with asset base collateral. Those are the type of things that we can do so we can actually help really good companies. For example, and unfortunately I say unfortunately for me it is, but 75% of my pipeline is oil and gas. I've been in Texas for 45 years. Oil and gas just follows here in Houston, Texas. And so just they call me that and maritime. So those two industries really can run our business alone. Although I would much rather have a lot of other manufacturer distribution and service companies than a lot of those companies. A lot of those CFOs owners of the companies, they have no clue what is available out there or why they can't get financing at the time. Maybe that's changing today, but at the time a lot of banks weren't allowed to venture into oil and gas. Oil and gas is a very cyclical industry, Randy: The ups and downs. If you don't do an oil and gas company in an asset based selection, you're bound to have trouble later on when the SLE falls because a lot of those assets can disappear. Randy: But on an asset based business, conventional banks can't do that. But not a lot of conventional banks are allowing their asset based lenders to do it today. So for example, I had a company that was a pipe manufacturer. They supplied from the pipe all the way to the dynamite and they had gone to eight different conventional banks, been declined every single time. When they came to me, I asked them, who'd you go to? Well, none of those guys have been to your deal because they're not allowed to. Their ownership was not allowing to do it. Took 'em to the first bank that I knew would do it, and we got that deal closed this year. A 30 million line of credit was with a $20 million accordion and well potential accordion they didn't need at the time because they were on the downhill run. But that bank knew how to do it. That bank, that lender knew how to do it. We knew who to go to. That deal got done. Dave: So let me just take a step back to make sure the audience understands. So your company doesn't actually yourself lend money. You're basically an intermediary between the capital markets, I guess primarily debt markets. Do you guys do any equity? Randy: We do some equity on the oil and gas side. I don't have that many providers on manufacturing distribution service, not oil and gas. Dave: It's mostly, yeah. And impart of what makes you unique is that you have, because of your background, you're able to match up the deal with the bank and want it simple Randy: For probably over 35 years. 35 years ago, a man by name of John Flatow at that time was at Briggs. Dave: Yeah, Randy: Put out this spreadsheet for me. And on the vertical column it had all of his customers on the horizontal column. It had everyone they could refer him to. What that did for me was realize that in the capital finance side where I was traveling throughout the United States, Canada, and sometimes Mexico, I was relating with so many financial providers and I've started taking down names and I've got a book, single page, probably 48 pages now of who does what likes, what their rates are, what their structure is. And so what makes us different than most other brokers is that, number one, I know what a bank can do and what they can't do. Randy: And when banks, we put together or I request all the financial information, all the documents that a banker would need in order that a financial officer would need, we put that together. We do our own pre-flight, which most all bankers now need to do to get credit to allow them to offer term sheets. We decide where the risk level is of each one of our customers after we decide if we can help 'em or not. Some customers don't have cash flow, they don't have collateral. Those two items combined make it a tough deal, impossible deal to do. But if they haven't waited too long, they're still survivable. There's so many options. We put together a pre-flight and then I go to that book and then we decide three up to three opportunities to take these financial providers. The difference between most brokers is most brokers don't know what they're looking at, don't know what's available, and they just chunking it out to 12 or 20 different institutions hoping something sticks. Randy: We go to three 95% of the time, we'll get three term sheets. Those are going to be at the right rate that the customer deserves and they're going to be the right structure. And then we take the closing and after closing, we help them negotiate or before closing, we help them negotiate the documents. We help 'em negotiate their term sheet and we get them through the entire process. Because most CFOs, well, I'm not going to say most, it's surprising how many CFOs don't know what's possible, don't know why a conventional bank can't help them and don't know why this other opportunity that's going to be 2% higher or more if the company's risk level is higher, why they have to do that. Many times, David, we'll have someone say, no, we're not going to take any of those term sheets. They're just too high. That that just doesn't make any sense to us. The structure's too tough, the administration's too tough. Okay, well get to more banks, go to more conventional banks, see if you can get your loan and if you can't come back, and that's where it's an education. It's an education that these CFOs need to go through it and they need to understand it to instruct their owners why they're doing what they're doing. Dave: And so you only get paid if you're able to successfully, Randy: We only get paid at closing at the closing table. We'll either obtain a success fee if it goes to conventional bank because if it goes to conventional bank, that's where I'm going to take it. That's what the client deserves. And it's always going to be a lower rate. It's always going to be less administration. And if I can do that, that's a win. Even though our fees are a lot of times going to be reduced because it's going to conventional bank and for that banker to be competitive, they can't pay our full fee. But if it goes to a capital finance company, the capital finance company is who's going to pay us. So the other doesn't have to pay us. If it goes to a capital finance company Dave: And if it goes to a bank are they Randy: Say bank, we need a success fee agreement Dave: From the Randy: We're going to be able to invoice the bank and at closing they'll pay us. Dave: Okay. So my listeners like stories. So let's talk about some examples. And again, I'm sure the client name will be anonymous, but give us just some stories to give us a sense of the types of deals that you guys can do. Randy: David, I'm going to throw out one that you referred to me yourself in front of some of your clients Dave: And Randy: We had a nice little discussion and at a later date, one of your clients called me for help. Dave: Yep, I know who you're talking about. Randy: Well, what we ended up doing is finding three other banks that could have helped him. Conventional banks. The client was definitely bank worthy, but his existing bank wasn't really working with him as much as they should have. While the client wanted the release of his personal guarantee at the size level that he was at, I had to educate him and convince him that since you're making every decision, you rule the company, you can do whatever you want to do with the company. They're going to want your personal guarantee to make sure that you stay in long. Randy: But that on the side, he deserved everything. He was, everything else he was asking for. He deserved a lower rate. He deserved a re amortization. So when he received the three term sheets that we provided him from other conventional banks, he went back to his existing bank and said, this is what I've got. And he got everything he was asking for the release of his personal guarantee. Well, he offered to pay me. There was nothing I could, I didn't do much. I didn't do anything extraordinary. It didn't take long to realize who he should be working with. So no charge. He went back to his original bank, got what he wanted and everybody's happy. So that's point. Dave: I know he was very appreciative of that. And that really goes to show the power or the ability you have to help clients. I mean, you effectively made a couple phone calls, I'm simplifying it, but you reached Randy: Out, it wasn't much more. Dave: You reached out to a couple people. You told 'em, Hey, this is a bankable deal. Their current banks may be taking advantage of 'em or doesn't see how bankable they really are, and this may be an opportunity for you. They threw out some turn sheets that was a wake up call for his current bank and they went ahead and because of the leverage he had of the other term sheets, his current bank suddenly became more reasonable Randy: And for no cost at all. He didn't have to get any appraisals, he didn't have to go through the underwriting process. The existing bank helped him. And yeah, bank that he was at is known as one of the most conventional banks in Texas. That's where he deserved to be because he deserved it. Dave: And I know of which bank you speak. Okay, well that's helpful. What about a deal, an example of somebody who wasn't as bankable and yet to go to the capital finance markets. Do you have an example of a deal like that? Randy: Sure. And it's not just because, I mean the company was doing well, but they were a provider of construction mats. So in other words, utilities are being put in, it's really muddy. It's been rainy. They provide their huge construction mats, large yellow equipment can go over, can drive over and not get stuck in the mud. Those mats are not that usable as collateral because they wear out real quick. Sure, sure. So who's going to do that? So we found a few companies that were willing to advance on those mats directly. Their existing company wasn't, their existing bank was not going to give them any more availability. If this company is growing and once we found them additional availability, the company has been able to grow. It's been able to find additional equity if they want it because once it started growing, they exists, said, I'm happy you're uncle and hunting. So they didn't want to do everything that we expected them to do was to go out and acquire other companies. We could have helped 'em grow to 200, $300 million. Dave: I've got you. Randy: Leon owner Dave: Just wasn't interested in Randy: All of a sudden the pressure was off his shoulders. I've got a great family, everything's taken care of. We're good. Dave: Okay. Randy: Now the issue with that is during the next dry season, he's not going to have the working capital to continue what he's doing. Dave: Right, right. Randy: He'll come back. Dave: Yeah. Randy: We expect that he'll come back. Dave: Okay. Randy: Is that what you were looking for? Dave: Yeah, yeah. Yeah. So I think you've kind of answered this question indirectly, but let me just ask you directly. So what is it that you enjoy the most about serving your clients in this capacity with your own gig? What do you enjoy the most about it? Randy: Well, even in my conventional bank days, I've always enjoyed ringing the bell and a deal gets done when we get a customer what he wants. And that is always endless. A struggle thing I can do. Dave: Yeah. Yeah. I knew that's what you were going to say. I know you John Flatow me, my wife. I mean we all relish serving customers in helping solve business problems for them. So that answer does not surprise me. Randy: Great. Dave: So that's coming from your perspective, what makes you different? What do your clients tell you about what makes you different? What are some feedback you've had from your clients? Randy: Well, we have an existing client right now that we're going to help him get purchase order financing Dave: And Randy: We're going to provide him an asset base loan and they purchase order facility on the side. And he found a conventional bank that agreed to do his deal that no other conventional bank would ever done at a fantastic rate, gave him 15 million instead of the 5 million he was asking for. Dave: Wow. Randy: Yeah. But he went there and he called me to tell me, Randy, I'm sorry I got bad news for you. I said, no, you found a great deal. As long as I can work with you. That is awesome. We'll get you the PO financing you take care of closing that deal at that bank and if they can't service it in the future, we'll take you back to through the banks that want to do it. Fact. That's great. That's still fine. So before he hung up, he said, Randy, you've really surprised me. I knew you wanted the sale of the asset based loan, but you're happy for me. You got the deal you wanted. I don't need to work. I do this, I enjoy it and it's I going to get the company the best thing I can get 'em. That kind of goes back to why did I start my own company, the stand my own company? Because conventional banks can't always do the common sense thing that the company means or we're doing it here. Dave: No, that is awesome. Yeah. I remember when you reached out to me and you started, I remembered thinking what a great fit, what great service you're offering that you're able to bring all of your expertise and because really what they're paying you for isn't your time, it's your knowledge is what they're really paying you for. They're not paying you for your time to reach out to 20 banks. A less the experienced person would do it is like the joke about the factory machinery that was down and they called in an engineer the story and he looked at it and he turned one screw, like half a turn and then gave him a $10,000 invoice and the owner was flabbergasted, why so much money? I need a detailed invoice. And his detailed invoice was turning the screw $1, knowing which screw to turn, $9,999. It's kind of the same way. Right? They're really paying you for your knowledge and your relationships, right? Randy: Correct. Absolutely. Dave: So what else, as we're kind of wrapping up here, what did I not ask you that you wish I had or I should have asked you? Randy: David, you're very good at what you do. You've asked me all the right questions. I've been able to tell you what we offer, why we're different, what we do. You've covered it. Okay, Dave: Well good. Well, I know you have helped many of my clients over the last 30 years in all of your different capacities, so I just wanted to thank you for that. You've always made me look good with my clients when I say, Hey, let me introduce you to Randy. Randy will take care of you. And that always makes me look good like this client, you had mentioned that you basically gave him leverage to renegotiate with his current bank. He'd been working on this problem for years and just was kind of hitting a wall because he sensed he could get a better deal, but he didn't really know how to go about that. He didn't really have the time and he didn't know if he just starts in the Yellow Pages. Well, I guess we don't have the yellow pages, but just starting at the eighties and just start calling all the banks. And then the problem is who you call at each bank. You can't just go to a retail branch and talk to the retail branch manager. So yes. Anyway, I appreciate over all these years you making me look like a star. Randy: You are one. David, I promise. Thank you for this opportunity. Dave: So I've got just one, two more questions and they're both fun. One is, if you could go back in time and give some advice to your 25 or 30-year-old self, what advice might you give to yourself Randy: And do what I'm doing now earlier? Dave: Yeah. That's the number one answer I get from my entrepreneur clients because almost, or my guest, almost all my guests had a similar path. They didn't just graduate from college and start their business. They didn't know, they didn't have any experience that always worked for somebody else for a while. Then they went on their own and they always have the same regret. They wish they'd been more courageous and done it sooner. So last one more. We're in Texas TexMex or barbecue? Randy: TexMex. Dave: Yeah. Randy: But worthy, I'll probably have both every week. Dave: Yeah. What's really good is if you find a place that's got great brisket tacos or brisket enchiladas, that kind of gives you a sense of both. So here's what a guest told me that I would have to agree with. He said it depends if it's average, I'm going to take the Tex-Mex. He goes, if I know that the option is too the barbecue place that's exceptional, and a Mexican restaurant that's exceptional, I take the barbecue because he said Tex-Mex has more capacity, more tolerance for average use, right? I mean, average Tex-Mex is still good, but average barbecue, not so much. Randy: I agree you 100%. Dave: That is great. Well, Randy, I really appreciate you taking time and I'm really excited to hear about what you're doing now and hopefully this episode will cost some people to reach out to you. We'll have your contact information in the show notes. So thanks again, Randy. Really appreciate it. Randy: Thank you David. Really appreciate it. Dave: There we have it. Another great episode. Thanks for listening in. If you want to continue the conversation, go to ic disc show.com. That's IC dash D-I-S-C-S-H-O w.com. And we have additional information on the podcast archived episodes as well as a button to be a guest. So if you'd like to be a guest, go select that and fill out the information and we'd love to have you on the show. So it we'll be back next time with another episode of the IC Disc Show. Special Guest: Randy Gartz.

Dans cet épisode, je reçois Amanda, dont le parcours bouleversant traverse le deuil périnatal, l'errance médicale et l'espoir né des avancées de la médecine génomique. Après la perte de plusieurs enfants et des années sans réponses, Amanda découvre en 2023 une incompatibilité génétique rare grâce au programme SEQOiA. Elle raconte son cheminement personnel, émotionnel et scientifique, entre souffrance et reconstruction. Aujourd'hui présidente de l'association Petite Émilie, elle accompagne d'autres parents confrontés à la perte d'un bébé. Ensemble, nous abordons avec délicatesse ce deuil encore tabou, les ressources pour y faire face, et les combats portés pour mieux accompagner les familles. Un épisode empreint de courage, de vérité et d'engagement.Axes abordés dans l'épisodeLe parcours personnel d'Amanda face au deuil périnatal et à l'interruption médicale de grossesseLe rôle de la médecine génomique dans la compréhension d'une incompatibilité génétique rareLes limites et les enjeux éthiques de la génétique dans les parcours familiauxLe processus de deuil invisible et les ressources pour les parents endeuillésLe rôle de l'entourage dans l'accompagnement des personnes en deuilL'engagement d'Amanda au sein de l'association Petite Émilie et les actions collectives menéesCheminements, c'est le podcast santé des femmes qui parlent de leur santé mentale, physique, et émotionnelle, sans honte, sans filtre et sans tabou. Chaque épisode, diffusé un lundi sur deux, vous plonge dans des récits authentiques et bouleversants.En ouvrant le dictionnaire, on apprend que "cheminement" désigne une progression graduelle, un mouvement, une avancée. Dans ce podcast, le cheminement est celui des femmes : leurs luttes, leurs victoires et leurs transformations face aux défis de la vie et de la santé.Dans Cheminements, le micro est tendu à des femmes du quotidien : vos voisines, collègues, soeurs ou amies. Elles témoignent de leur santé mentale, physique ou sociale, partagent leurs parcours uniques et osent enfin lever le voile sur des sujets trop souvent passés sous silence.Ce podcast santé donne la parole à celles qui méritent d'être entendues. Chaque histoire, portée avec sincérité, met en lumière des réalités humaines, parfois douloureuses, mais toujours humaines.

Cédric Jubillar condamné à 30 ans de prison pour le meurtre de sa femme Delphine. Mourad Battikh, avocat de l'oncle et de la tante de Delphine Jubillar, et Cécile Ollivier grand reporter police-justice au magazine ELLE France, sont nos invitésLe vendredi et le samedi à partir de 18h57 sur France 5, Mohammed Bouhafsi et toute son équipe accueillent celles et ceux qui font l'actualité du jour.

In this episode of the Scotland Matters podcast, host Cameron Gillies catches up with the Chair of the Scottish Land Commission, Michael Russell, and SLE's CEO Sarah-Jane Laing to explore the complexities of land reform in Scotland..The discussion delves into the historical context of land ownership, evolving perspectives on land use, and the balance between regulation and community engagement. They discuss the importance of public benefit, social responsibility, and the need for effective communication between landowners and communities. They also address the challenges of defining success in land reform and the future of land ownership in Scotland, highlighting the importance of both scale and diversity when it comes to land management.As always, thank you for supporting the podcast and if you'd like to find out more check out the links below!Watch us on YouTube -⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UCZh6HQRipgDGqJDHxhSXVQg⁠⁠⁠⁠⁠⁠⁠⁠Find out more about Scottish Land & Estates - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.scottishlandandestates.co.uk⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Find out about the Helping it Happen Awards - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.scottishlandandestates.co.uk/helping-it-happen

Monreal asegura que Ley de Amparo será revisada sin retroactividad SMN alerta por lluvias intensas en el sureste del paísLeón XIV llama a la reconciliación frente a la crisis migratoriaMás información en nuestro podcast

Aujourd'hui un épisode avec Benoît Magand, co‑fondateur de La Compagnie des Déboucheurs — l'enseigne qui transforme le débouchage de canalisations en réseau national à impact.Dans cet épisode, Benoît nous partage :Comment il a cofondé l'activité en 2015/2016, en partant d'un constat simple : les urgences de canalisations étaient souvent mal traitées.L'idée de créer une marque “réassurante”, avec des tarifs transparents, une garantie de résultat, et une image décalée dans un métier trop souvent stigmatisé.Leur passage en franchise dès 2018 avec aujourd'hui plus de 100 franchisésLe soutien aux franchisés : formation, centrale d'appel, logistique, exclusivité territoriale… tout est pensé pour les faire réussir.L'élargissement des services avec le chemisage de canalisation, pour aller au-delà du simple débouchage.Et enfin, ses envies d'international, avec l'ambition de porter cette success story française au-delà de nos frontières.☕ Un épisode passionnant sur l'entrepreneuriat de terrain, la force d'une marque bien construite, et la capacité à scaler un service là où personne ne vous attend.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Dr Raquel Faria and Professors Ricard Cervera and Ronald van Vollenhoven discuss the recently published EULAR recommendations for a core dataset to support clinical care and translational and observational research in SLE.Disclaimer: During Lupus Academy podcast episodes, participants may refer to off-label use of medicines for patients with lupus. Lupus Academy does not make anyrecommendations about using a medicine outside the terms of its approved license for use.

Pourquoi 40% des femmes de 30-35 ans refusent le mariage. Analyse du phénomène qui redéfinit l'amour au 21ème siècle et ses raisons légitimes.

Cette affaire est l'un des faits divers les plus célèbres et mystérieux de la France du XIXᵉ siècle. Elle mêle crimes sordides, rumeurs terrifiantes et un procès retentissant. Le décor : une auberge isoléeNous sommes sur le plateau du Gévaudan, en Haute-Loire, au début du XIXᵉ siècle. À l'époque, la route reliant Lyon à Toulouse est très fréquentée par des voyageurs, colporteurs et commerçants. Sur ce chemin se trouve une petite auberge isolée, tenue par Pierre et Marie Martin, un couple de paysans. Cette auberge, située à Peyrebeille, va bientôt devenir tristement célèbre sous le nom d'« Auberge rouge » en raison de la réputation sanglante qui l'entoure.Les rumeursTrès vite, des rumeurs commencent à circuler : des voyageurs y disparaissent mystérieusement. On raconte que les aubergistes attireraient leurs clients dans des chambres, puis les assommeraient avant de les dépouiller et de dissimuler les corps. L'imaginaire populaire évoquera même une sinistre méthode : un lit piégé basculant la victime dans une trappe, pour l'achever ensuite. Ces histoires terrifiantes, bien que jamais prouvées, forgent la légende noire de l'auberge.L'affaire éclateEn 1831, un colporteur est retrouvé mort non loin de Peyrebeille. Rapidement, les soupçons se tournent vers les époux Martin et leur domestique, Jean Rochette. L'enquête révèle que plusieurs disparitions pourraient être liées à l'auberge. Le couple est alors accusé d'avoir tué de nombreux voyageurs pour voler leur argent et leurs biens. Le chiffre de plus de cinquante victimes sera avancé par certains journaux de l'époque, mais il repose davantage sur des rumeurs et des exagérations que sur des preuves formelles.Le procèsLe procès s'ouvre en 1833 à Privas. Il passionne l'opinion publique, avide de sensations fortes. Les débats sont marqués par une forte charge émotionnelle et une presse avide de scandale. Les aubergistes sont décrits comme des monstres sans scrupules. Finalement, Pierre Martin, son épouse Marie et Jean Rochette sont condamnés à mort. Ils sont guillotinés le 2 octobre 1833 devant une foule considérable.Mythe ou réalité ?L'historiographie récente nuance beaucoup l'affaire. En réalité, les preuves contre les époux Martin étaient minces. Si leur culpabilité dans un ou deux meurtres paraît probable, l'image de tueurs en série méthodiques relève surtout de la légende, amplifiée par la presse et par l'imagination populaire. L'« Auberge rouge » est ainsi devenue un symbole : celui de la fascination morbide pour les crimes mystérieux dans la France du XIXᵉ siècle.HéritageAujourd'hui encore, l'auberge de Peyrebeille existe, transformée en musée. L'affaire continue d'inspirer livres, films et récits, entre réalité judiciaire et légende noire. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Dans cet épisode, on aborde un phénomène trop peu discuté mais pourtant central dans l'apprentissage du français et des langues étrangères : la fossilisation des erreurs.Depuis quelques années, un nouveau type de difficulté se fait entendre : les fautes de grammaire à l'oral. Elles ne sont pas de simples erreurs de débutant, mais des erreurs répétées, qui finissent par s'installer durablement dans la langue de l'apprenant… au point de devenir très difficiles à corriger.Les causes sont multiples :➡️La consommation excessive de contenus gratuits, sans suivi personnalisé➡️Le manque de correction régulière➡️Des enseignants peu formés ou trop peu expérimentésLe problème est que, lorsqu'une erreur se fossilise, le cerveau la considère comme correcte. Et la désapprendre demande beaucoup plus d'efforts. Un exemple concret : une élève prononce “alcool” [alku] au lieu de [alkool]. Malgré plusieurs corrections, son cerveau continue à revenir vers la mauvaise version.Alors, comment éviter ce piège ? La solution est simple, mais exigeante : travailler avec un professeur expérimenté. Lui seul peut repérer tes erreurs récurrentes, te corriger au bon moment et t'aider à désapprendre ce qui s'est enraciné dans ton français.Apprendre seul(e), sans cadre ni correction, peut sembler tentant, mais mène souvent à :➡️Trop de ressources dispersées➡️Manque de structure➡️Procrastination➡️Absence de progression mesurableBref, apprendre le français seul(e) est rarement efficace. L'accompagnement personnalisé fait toute la différence.Et toi, as-tu remarqué des erreurs fossilisées dans ton apprentissage du français ?Lien :Épisode 124 : Comment devenir polyglotte ? Avec Luca Lampariello“Le Français avec Yasmine” existe grâce au soutien des membres et élèves payants. 1️⃣ Le Club de Yasmine Le Club privé du podcast qui donne accès à toutes les transcriptions des épisodes, à 6 épisodes secrets par an, la newsletter privée en français et l'accès à la communauté des élèves et membres sur Discord. https://lefrancaisavecyasmine.com/club 2️⃣ Les livres du podcast Les transcriptions du podcast sont disponibles dans les livres sur Amazon : http://amazon.com/author/yasminelesire 3️⃣ Les cours de français avec YasmineRendez-vous sur le site de mon école pour découvrir le catalogue des cours disponibles : www.ilearnfrench.eu ➡️ Les réseaux sociaux Instagram : https://www.instagram.com/ilearnfrench/LinkedIn : https://www.linkedin.com/in/yasmine-lesire-ilearnfrench/ ➡️ Crédit musique La musique de cet épisode est créée par le groupe Beam. Merci à Maayan Smith et son groupe pour la musique. Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Affaire Robert Boulin : plus de 45 ans après, le mystère reste entier. Me Didier Seban, avocat de Fabienne Boulin, fille de Robert Boulin, et Benoît Collombat, directeur de la cellule investigation de Radio France sont nos invitésLe vendredi et le samedi à partir de 18h57 sur France 5, Mohammed Bouhafsi et toute son équipe accueillent celles et ceux qui font l'actualité du jour.

Épisode 1358 : Youpi c'est lundi et toutes les applications veulent devenir des réseaux sociaux ! Spotify, Roblox, même Netflix… On se parle aussi des notes communautaires de Méta, des nouvelles règles de TikTok et de LinkedIn qui ajoute deux nouvelles KPI les “Saves” et les “Sends”. Roblox copie TikTok et veut devenir un réseau social à part entièreRoblox lance Moments, un nouveau fil d'actualité vertical inspiré directement du "Pour Toi" de TikTok. https://corp.roblox.com/newsroom/2025/09/roblox-moments-user-generated-discoveryAvec Moments, les utilisateurs peuvent enregistrer jusqu'à 30 secondes de gameplay, les éditer, et les partager dans un flux vertical, sans commentaires mais avec des réactions.L'algorithme pousse ensuite ces vidéos selon les préférences des joueurs. Objectif : accroître le temps passé sur la plateforme et stimuler la production de contenu natif.Une manière pour Roblox de s'imposer comme un média social immersif à part entière — et non plus uniquement comme un moteur de jeu.Ce pivot vers le scroll infini confirme une tendance de fond : chaque plateforme veut son propre TikTok. YouTube avec Shorts, Instagram avec Reels, et maintenant Roblox, qui capitalise sur l'UGC des jeunes pour structurer une offre média.Une stratégie cohérente pour fidéliser les ados, et transformer une plateforme de jeu en un véritable écosystème d'attention.

Vous créez du contenu… mais vos commerciaux ne l'utilisent pas ?Vous êtes commercial… et vous ne voyez pas l'intérêt des contenus marketing ?Dans cet épisode, on vous montre comment faire mieux – ensemble - et créer du contenu qui vend.Avec Alexandre Waquier, cofondateur du studio Pastel et hôte du podcast Les Héros de la vente, on parle d'un sujet trop souvent mis de côté : comment utiliser le contenu pour vendre plus efficacement… sans y passer des heures.Au programme :Pourquoi le contenu est un levier encore sous-exploité pour vendre Les formats qui aident vraiment à closer (et ceux à oublier)Comment un simple live LinkedIn peut générer des leads ultra-qualifiésLe podcast comme arme de prospection : méthode et exemples concretsComment impliquer vos commerciaux dans la création de contenu qui vend sans les transformer en marketeursL'IA générative, un allié pour aligner marketing et sales sans frictionsUn épisode qui vous donnera des idées concrètes pour mieux faire travailler ensemble contenu et performance commerciale avec du contenu qui vend.

Drs. Chaichian and Dall'Era review the updated guidelines for the treatment and management of SLE in children and adults.

After an exciting week in New York…Scottsdale Fashion Week is gearing up to strut its stuff  this month. The city's most high-end showcase of fashion….Scottsdale Fashion Week is back September 25th through 28th. It's a star-studded event with a packed lineup of shows, activities, and venues that draw thousands of attendees.  Throughout the week, the city comes alive with designers, buyers, stylists, celebrities, VIPs, and all kinds of special guests.  Each night brings a new vibe—colorful venues, fresh designers, and a whole lot of glamour.  It's really one of the biggest weekends for the local industry coming together for an unforgettable fashion experience.  And to tell us more about it, we've got two very special guests: Jamie LeVine  and Sheree Hartwell.  Now let me tell you about some fun events coming up in Scottsdale. Scottsdale Fashion Week!  September 25- 28th - various events around the city.  Check out the Scottsdale Fashion Week website for Tickets and event information at  https://scottsdalefashionweek.com/ The Junk in the Trunk Vintage Market September 12- 14th at Westworld of Scottsdale A  must-attend event for lovers of all things vintage, handmade, and beautifully curated.  The Market features more than 160 vendors from across the country, offering everything from chippy furniture and architectural salvage to vintage fashion, handmade jewelry, and whimsical home décor. https://junkinthetrunkvintagemarket.com/ Arabian National Breeder Finals September 10th - 13th at Equidome Arena  This prestigious show offers the Arabian horse community the opportunity to showcase the very best the breed has to offer in an unparalleled venue. Admission is free, so be sure to check out their website for more information. https://www.scottsdaleshow.com/shows/arabian-national-breeder-finals

After an exciting week in New York…Scottsdale Fashion Week is gearing up to strut its stuff  this month. The city's most high-end showcase of fashion….Scottsdale Fashion Week is back September 25th through 28th. It's a star-studded event with a packed lineup of shows, activities, and venues that draw thousands of attendees.  Throughout the week, the city comes alive with designers, buyers, stylists, celebrities, VIPs, and all kinds of special guests.  Each night brings a new vibe—colorful venues, fresh designers, and a whole lot of glamour.  It's really one of the biggest weekends for the local industry coming together for an unforgettable fashion experience.  And to tell us more about it, we've got two very special guests: Jamie LeVine  and Sheree Hartwell.  Now let me tell you about some fun events coming up in Scottsdale. Scottsdale Fashion Week!  September 25- 28th - various events around the city.  Check out the Scottsdale Fashion Week website for Tickets and event information at  https://scottsdalefashionweek.com/ The Junk in the Trunk Vintage Market September 12- 14th at Westworld of Scottsdale A  must-attend event for lovers of all things vintage, handmade, and beautifully curated.  The Market features more than 160 vendors from across the country, offering everything from chippy furniture and architectural salvage to vintage fashion, handmade jewelry, and whimsical home décor. https://junkinthetrunkvintagemarket.com/ Arabian National Breeder Finals September 10th - 13th at Equidome Arena  This prestigious show offers the Arabian horse community the opportunity to showcase the very best the breed has to offer in an unparalleled venue. Admission is free, so be sure to check out their website for more information. https://www.scottsdaleshow.com/shows/arabian-national-breeder-finals

Il y a quelques mois, on me souffle un nom : Chelsea Fagan. Fondatrice du média américain The Financial Diet, 1,3 million d'abonnés sur YouTube, une voix féministe et badass qui parle d'argent avec expertise, humour... et sans bullshit.Quelques heures de rabbit hole plus tard, je la contacte. Elle parle un français parfait. Et grâce à un alignement des astres, on se voit et on enregistre dans la foulée.Dans cet épisode, on parle de ce qui nous obsède des deux côtés de l'Atlantique (avec quelques anglicismes indeed) :L'importance de parler d'argent pour éviter le gaslighting socialLa solitude financière des femmes dans le couple hétéroLe concept du hedonic treadmill (insatisfaction permanente, course à la croissance)La culpabilité maternelle et ses conséquences sur l'argent des femmesLe poids des normes sociales, la charge mentale, les fausses égalitésLe problème des golden handcuffs (enchaînement à un salaire élevé)Pourquoi l'argent doit acheter du temps et pas des objetsL'argent comme squelette invisible de nos viesÉvidemment, on a abordé plein d'autres choses, dont pas mal de guilty pleasures pour ma part, comme les personnages de Sex and the City, le modèle économique mensonger des tradwives. Ah, et on a aussi un peu balancé sur les influenceurs lifestyle et les mariages hors de prix (c'est toujours bien de se découvrir des combats communs).Alors oui, c'est interview de fan. Mais j'avoue, j'ai pris un immense plaisir à discuter avec Chelsea. Et pour la toute première fois, cet épisode de Thune est intégralement filmé et disponible sur YouTube. C'est peut-être un détail pour vous, mais pour nous, c'est le début de quelque chose (de plus ou moins assumé).Bonne écoute !C'est important : vous êtes déjà nombreux.se.s à nous faire un don mensuel sur Tipeee. Il nous manque encore un peu d'argent pour que le podcast puisse continuer en toute indépendance. Si vous trouvez notre projet utile et souhaitez nous soutenir, c'est ici. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this episode of ACR Journals on Air, host Dr. Vicki Shanmugam speaks with Dr. Alain Sanchez-Rodriguez about a new study from the Lupus Midwest Network (LUMEN), published in Arthritis Care & Research. They explore how patients with systemic lupus erythematosus (SLE) experience delays and disparities in care, the types of physicians involved in diagnosis, and what the data reveals about access to specialized treatment. Dr. Sanchez-Rodriguez also shares his research journey and insights on improving equity in rheumatology. 

It's been over two decades since the American College of Rheumatology (ACR) last released comprehensive treatment guidelines for systemic lupus erythematosus (SLE), and much has changed. In this episode, we're joined by Dr. Lisa Sammaritano to discuss the forthcoming 2025 ACR Guidelines for the Treatment of SLE. These updated recommendations reflect a significant evolution in our approach to lupus care, from the growing range of therapeutic options to a stronger emphasis on patient engagement and minimizing steroid toxicity. We'll dive into how the guidelines tailor treatment across diverse organ systems and patient populations, and what clinicians need to know to effectively incorporate these updates into their practice. 

Panélistes : @SylvainDementi  MH la lectrice : https://www.instagram.com/mh_la_lectrice/ @bibliofoliesdesalome  Maeva : https://www.instagram.com/maevaenvadrouille/Marina (la bio qui lit) : https://www.instagram.com/labioquilit/Livres mentionnésLe croque-en-murs, Mickaël Brun-ArnaudMémoires de la forêt, Mickaël Brun-ArnaudLes racistes n'ont jamais vu la mer, Rodney Saint-Éloi et Yara El-GhadbanFais ça comme un grand, Tristan DemersLe sujet du féminisme est-il blanc? : femmes racisées et recherche féministe, Naïma HamrouniLa danse des flamants roses, Yara El-GhadbanMeet Me at the Lake, Carley FortuneOne Golden Summer, Carley FortuneThis Summer Will Be Different, Carley FortuneEvery Summer After, Carley FortunePour l'amour des hommes : Dialogue pour une masculinité positive, Liz PlankAnne et la maison aux pignons verts, Lucy Maud MontgomerySeul le vent connaît mon nom, Isabel AllendeLà où les détours m'emportent, Rachel LucyThe Summer I Turned Pretty, Jenny HanDiamant tendre, Amélie DumoulinClang ! Carole TremblayCoup bas, Laurie LéveilléGarçon manqué, Samuel ChampagneÉloi, Samuel ChampagneNoa, intersexe, Samuel ChampagneFé M Fé, Amélie DumoulinSalauds, Sylvie G.Marie-Pier LafontaineIn waves, AJ DungoHomicides, Pascal BrullemansSon odeur après la pluie, Cédric Sapin-Defour Chercher Sam, Sophie BienvenuServante écarlate, Margaret AtwoodHomo sapienne, Niviaq KorneliussenUn roman au four, Marie-Sissi LabrècheLa vieille qui court, Catherine St-GermainPoudreuse, Sophie Lalonde-RouxHexa, Gabrielle Filteau-ChibaBalados québécois livresquesFilles de papierUn dernier chapitreContient des spoilersLe fil rougeVraiment littTrois filles et un livreSecrets d'éditionDis-moi ce que tu lisLe temps d'un livreLes survenantesLe temps d'un livreLa sapience

Vous cherchez à trouver de nouveaux clients rapidement, sans vous lancer dans des stratégies marketing compliquées qui prennent des mois ? Dans cet épisode, je vous partage 7 actions simples et concrètes que vous pouvez mettre en place dès aujourd'hui pour signer un nouveau client dans les 7 prochains jours.Au programme :Comment réactiver ton réseau "chaud" avec une approche qui fonctionneLa technique de l'audit express gratuit pour créer un lien immédiatComment créer une offre flash irrésistibleLe pouvoir des témoignages avant/aprèsLe mystérieux email de 9 mots qui obtient des résultats étonnantsEt plus encore!Votre objectif après cet épisode : choisir au moins 2 de ces stratégies et les mettre en place dès lundi. Pas besoin de gros budget, ni de plan marketing complexe, ni de publicité payante : juste de l'action ciblée et efficace.—————————————✨ [Quiz] Découvrez quel type d'entrepreneur vous êtes et quelle stratégie adopter, en fonction de votre personnalité

This week, we explore the potential role of sodium-glucose cotransporter-2 (SGLT2) inhibitors in patients with systemic lupus erythematosus (SLE) and comorbid type 2 diabetes (T2D)—a population historically excluded from landmark SGLT2i trials. Our guest, Dr. Karen Costenbader, discusses the rationale behind the study, the nuances of trial emulation design, and key findings regarding cardiovascular and renal outcomes, infection risk, and prescribing patterns in this complex cohort. We also unpack implications for clinical decision-making and the evolving landscape of metabolic and cardiovascular care in autoimmune disease. 

If you're an electrician wondering why your process isn't scaling... this episode will change how you see yourself in the business.In this episode of the Million Dollar Electrician Podcast, Clay and Joe unpack the real barriers behind sales slumps, mindset crashes, and why some electricians double their revenue while others spin their wheels.You'll hear the raw truth about how business stagnation often starts with what's not being addressed personally. You'll see the exact mindset behind $48K service tickets… and why full belief is the only thing separating those who win from those who spin their wheels.Whether you're the visionary who sees 100 doors or the specialist who thrives in the final 20%—this episode will hold a mirror up and unlock something that's been sitting in your blind spot.If you've ever felt stuck, tired, or unsure what to do next... you're not alone. But there is a way forward.You'll discover:-The hidden mental chokeholds that sabotage your service calls-Why your own self-doubt is triggering homeowner objections-How a foggy head = foggy panel = foggy profit-The “Architect vs Specialist” spectrum — and why knowing where you fall changes everything-The truth behind belief-driven performance: if you don't trust the play, you'll fumble it-How to stop reinforcing the weakest point in your process and start trusting what works

Welcome to HCPLive's 5 Stories in Under 5—your quick, must-know recap of the top 5 healthcare stories from the past week, all in under 5 minutes. Stay informed, stay ahead, and let's dive into the latest updates impacting clinicians and healthcare providers like you! Interested in a more traditional, text rundown? Check out the HCPFive! Top 5 Healthcare Headlines for June 16-22, 2025: Pemvidutide Shows Significant MASH Effects, Weight Loss at 24 Weeks in Phase 2b IMPACT Trial Topline phase 2b data show pemvidutide achieved significant rates of MASH resolution and fibrosis improvement alongside meaningful weight loss at 24 weeks, positioning it as a promising candidate for metabolic liver disease treatment. FDA Approves Belimumab (Benlysta) Autoinjector for Pediatric Lupus Nephritis The FDA approved a belimumab autoinjector for at-home subcutaneous use in children as young as five with active lupus nephritis, providing the first approved biologic self-injection option for pediatric SLE and LN. Phase 3 Trial Results Announced for Sotatercept-csrk in Pulmonary Arterial Hypertension Positive phase 3 results show sotatercept-csrk added to background therapy reduced time to clinical worsening events in adults with PAH, supporting its potential as an effective treatment for this high-risk population. Compass Pathways' COMP360 Psilocybin Shows Benefit in Phase 3 TRD Trial COMP360 psilocybin demonstrated a significant reduction in depression symptom severity in treatment-resistant depression, meeting the primary endpoint in a pivotal phase 3 trial. Once-Monthly Obesity Drug, MariTide, Achieves Weight Loss Up to 16% at 1 Year Phase 2 data indicate once-monthly MariTide induces substantial weight loss of up to 16% over one year, with additional improvements in glycemic control, highlighting its promise for obesity and type 2 diabetes management.

Lupus, SLE, Methionin, LowCarb, Messen

Dr Raquel Faria and Professor David Isenberg review selected highlights from the 16th International Congress on SLE. Join us for a groundbreaking discussion on the latest inlupus research, clinical trials, guidelines and patient reported outcomes.Disclaimer: During Lupus Academy podcast episodes, participants may refer to off-label use of medicines for patients with lupus. Lupus Academy does not make anyrecommendations about using a medicine outside the terms of its approved license for use.

Most electricians are chasing the wrong thing, high-dollar installs with low repeat value. But what if the real power play has been sitting in your truck bed this whole time?In this powerful episode, we're joined by Jesse Hurt, a sales leader at DuroMax Power. With a career that started from the bottom and now spans decades in the generator industry, Jesse brings hard-earned insight into why portable, dual fuel, and tri-fuel generators are a hidden goldmine for service electricians.We share why the real money isn't in the install, it's in the relationship.If you've been ignoring generators, this might be the most important episode you listen to this year. 

In this episode, CardioNerds Dr. Gurleen Kaur, Dr. Richard Ferraro, and Dr. Jake Roberts are joined by Cardio-Rheumatology expert, Dr. Monica Mukherjee, to discuss the role of utilizing multimodal imaging for cardiovascular disease risk stratification, monitoring, and management in patients with chronic systemic inflammation. The team delves into the contexts for utilizing advanced imaging to assess systemic inflammation with cardiac involvement, as well as the role of imaging in monitoring various specific cardiovascular complications that may develop due to inflammatory diseases. Audio editing by CardioNerds academy intern, Christiana Dangas. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls - Cardiovascular Multimodality Imaging & Systemic Inflammation Systemic inflammatory diseases are associated with an elevated CVD risk that has significant implications for early detection, risk stratification, and implementation of therapeutic strategies to address these risks and disease-specific complications. As an example, patients with SLE have a 48-fold increased risk for developing ASCVD compared to the general population. They may also develop disease-specific complications, such as pericarditis, that require focused imaging approaches to detect. In addition to increasing the risk for CAD, systemic inflammatory diseases can also result in cardiac complications, including myocardial, pericardial, and valvular involvement. Assessment of these complications requires the use of different imaging techniques, with the modality and serial studies selected based on the suspected disease process involved. In most contexts, echocardiography remains the starting point for evaluating cardiac involvement in systemic inflammatory diseases and can inform the next steps in terms of diagnostic study selection for the assessment of specific cardiac processes. For example, if echocardiography is completed in an SLE patient and demonstrates potential myocardial or pericardial inflammation, the next steps in evaluation may include completing a cardiac MRI for better characterization. While no current guidelines or standards of care directly guide our selection of advanced imaging studies for screening and management of CVD in patients with systemic inflammatory diseases, our understanding of cardiac involvement in these patients continues to improve and will likely lead to future guideline development. Due to the vast heterogeneity of cardiac involvement both across and within different systemic inflammatory diseases, a personalized approach to caring for each individual patient remains central to CVD evaluation and management in these patients. For example, patients with systemic sclerosis and symptoms of shortness of breath may experience these symptoms due to a range of causes. Echocardiography can be a central guiding tool in assessing these patients for potential concerns related to pulmonary hypertension or diastolic dysfunction. Based on the initial echocardiogram, the next steps in evaluation may involve further ischemic evaluation or right heart catheterization, depending on the pathology of concern. Show notes - Cardiovascular Multimodality Imaging & Systemic Inflammation Episode notes drafted by Dr. Jake Roberts. What are the contexts in which we should consider pursuing multimodal cardiac imaging, and are there certain inflammatory disorders associated with systemic inflammation and higher associated CVD risk for which advanced imaging can help guide early intervention? Systemic inflammatory diseases are associated with elevated CVD risk, which has significant implications for early detection, risk stratification, prognostication, and implementation of therapeutic strategies to address CVD risk and complicat...

Les parents, les enseignants et même... soi-même : tout le monde est très fort pour envoyer de la pression autour des résultats scolaires. Bien travailler c'est important à condition de surveiller le niveau de stress !Ma Vie d'ado, c'est le podcast du magazine Okapi. Ici, des collégiens parlent d'eux-mêmes, de leurs amis, de leurs familles et de leurs profs. Ils évoquent leur vie intime, au collège, en famille, seuls ou entre potes. Amour, amitié, délires... ils partagent aussi leurs colères, leurs coups de coeur, leurs angoisses et... leurs espoirs.  Ma Vie d'ado, c'est intime, c'est joyeux, c'est drôle, c'est triste, c'est mouvementé… C'est bouleversant comme une vie d'ado !Ma Vie d'ado, un podcast du magazine Okapi, à retrouver tous les quinze jours, dès le 1 er septembre, en même temps que le magazine !Crédits.Ce podcast est préparé et animé par le magazine Okapi (Bayard Jeunesse)  Un épisode réalisé avec la participation des classes des collèges George Pompidou à Champtoceaux (49), Camille Claudel, François Villon et Jean-Baptiste Clément, à Paris (75), Jules Verne à Vittel (88) et les collégiens Conseillers/Délégués départementaux du Gard à Nîmes (30) , René Cassin à Grand-Pontouvre (16), Gilles Gahinet à Arradon (56), Voix : Julie Pialot. Conception, réalisation, mixage : Emmanuel Viau. Montage : Yann Bonicatto. Musique  : Fixxions. Animation éditoriale : J-Y Dana / E. Viau./H.Devannes .  Production :  E.Viau. Un podcast de Bayard Jeunesse 2025- Droits réservésLe premier podcast des collégiens !https://www.okapi.fr/Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Dr Raquel Faria and Professor David Isenberg discuss the impact of neurological events in SLE including their associated mortality risk, effect on patients' QoL, fatigue and persistent neurological impairment throughout life.Disclaimer: During Lupus Academy podcast episodes, participants may refer to off-label use of medicines for patients with lupus. Lupus Academy does not make anyrecommendations about using a medicine outside the terms of its approved license for use.

Il y a autant de formes d'autorité que de parents. Et autant de manières de la recevoir, que d'ados !Ma Vie d'ado, c'est le podcast du magazine Okapi. Ici, des collégiens parlent d'eux-mêmes, de leurs amis, de leurs familles et de leurs profs. Ils évoquent leur vie intime, au collège, en famille, seuls ou entre potes. Amour, amitié, délires... ils partagent aussi leurs colères, leurs coups de coeur, leurs angoisses et... leurs espoirs.  Ma Vie d'ado, c'est intime, c'est joyeux, c'est drôle, c'est triste, c'est mouvementé… C'est bouleversant comme une vie d'ado !Ma Vie d'ado, un podcast du magazine Okapi, à retrouver tous les quinze jours, dès le 1 er septembre, en même temps que le magazine !Crédits.Ce podcast est préparé et animé par le magazine Okapi (Bayard Jeunesse)  Un épisode réalisé avec la participation des classes des collèges George Pompidou à Champtoceaux (49), Camille Claudel, François Villon et Jean-Baptiste Clément, à Paris (75), Jules Verne à Vittel (88) et les collégiens Conseillers/Délégués départementaux du Gard à Nîmes (30) , René Cassin à Grand-Pontouvre (16), Gilles Gahinet à Arradon (56), Voix : Julie Pialot. Conception, réalisation, mixage : Emmanuel Viau. Montage : Yann Bonicatto. Musique  : Fixxions. Animation éditoriale : J-Y Dana / E. Viau./H.Devannes .  Production :  E.Viau. Un podcast de Bayard Jeunesse 2025- Droits réservésLe premier podcast des collégiens !https://www.okapi.fr/Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Discussion of the diagnosis, management, and latest insights into cutaneous manifestations of SLE. Panelists: Dr. Victoria P. Werth, Dr. Matilda Nicholas; Dr. Anthony Fernandez; and, Dr. Christopher Richardson.

Liberty's story | Trying to get pregnant | the power of bone broth | filtering water | choosing the right exercise so the body isn't stressed | endocrine disruptors in household products | Liberty's routine

Season FOUR Episode FIFTEEN of the Your Story Our Fight® podcast welcomes Chantelle Chandler. Chantelle is a resilient lupus warrior who has been navigating life with systemic lupus erythematosus (SLE), hypothyroidism, rheumatoid arthritis, and Raynaud's syndrome for over three decades. In addition to managing these autoimmune conditions, she has also lived with jugular deep vein thrombosis (DVT) for the past 28 years. Through it all, Chantelle continues to embody strength, perseverance, and advocacy for others living with chronic illness.

À Mexico City, dans les quartiers de la Condesa et la Roma, très prisés des touristes et des étrangers, la sauce piquante ne pique plus. Dans les taquerias, ces traditionnels stands de vente de tacos que tous les Mexicains dégustent arrosés de sauce pimentée, le piment a été banni. Cela peut paraître anecdotique, mais veut dire beaucoup sur la gentrification de cette partie de la ville. Reportage de notre correspondante à Mexico City, Marine Lebègue.Dette haïtienne : après les annonces d'Emmanuel Macron, des réactions mitigéesPour l'homme d'affaires et auteur haïtien Jerry Tardieu, joint par RFI, l'annonce d'une commission mixte franco-haïtienne est « une première étape qui doit en appeler d'autres ». L'homme politique insiste, cela ne devra pas être seulement un travail mémoriel aboutissant à des mesures symboliques. « Il faut du concret (…) une forme de compensation (…) Le pays est à l'agonie, il faut que cette commission aboutisse à donner les moyens à Haïti de se battre contre l'insécurité » et de se développer.Dans les rues de Port-au-Prince, notre reporter Peterson Luxama a recueilli la parole d'Haïtiens en demande de réparation et restitution, deux termes éludés par le communiqué de la présidence française publié hier. « Cela doit prendre la forme d'un dédommagement. Cette sois disant dette a plombé notre économie. Je pense que le seul mot qu'on aimerait entendre aujourd'hui, c'est le mot restitution », déclare Roobens Isma, étudiant, à notre journaliste.Haïti : en Artibonite, la vie rendue impossible par les gangsÀ Port-au-Prince, comme dans le département de l'Artibonite, au nord, les habitants sont descendus dans la rue, fin mars, pour réclamer aux autorités des actions concrètes pour lutter contre cette insécurité. Dans la commune de Petite Rivière de l'Artibonite, contrôlée par le gang « Gran Grif » (le plus violent de la région), la population exige une réponse musclée de la Police nationale haïtienne. Reportage sur place de notre correspondant Ronel Paul.États-Unis : une photo de l'habitant du Maryland, Salvadorien, expulsé par erreur, à la Une de la presseSur cette photo, Kilmar Abrego Garcia, Salvadorien expulsé par erreur des États-Unis, est attablé dans le hall d'un hôtel de San Salvador avec le sénateur démocrate Van Hollen.Le père de famille, résident dans le Maryland est vêtu d'une chemise à carreaux et d'une casquette. « Ces photos renvoient une atmosphère bien différente de celle d'une prison surpeuplée », les deux hommes étant assis dans un hall d'hôtel, « au sol ciré », « avec une végétation luxuriante en arrière-plan », analyse le New York Times.La photo a été repostée aussi par le président salvadorien, autoritaire et fervent supporter de Donald Trump. Nayib Bukele se permet une légende moqueuse, rapportée par Politico : « Kilmar Abrego Garcia miraculeusement ressuscité des camps de la mort et de torture, en train de siroter une margarita ». Mais d'après les informations du New York Times, c'est un assistant de Bukele qui aurait servi les cocktails et tenté de mettre en scène la photo.En Floride, une tuerie fait au moins 2 morts et 6 blessésLe suspect de 20 ans, abattu sur place par la police, a agi avec l'arme de service de sa mère, adjointe du shérif du comté de Leon. Le Miami Herald raconte la panique sur place, « les ordinateurs et sacs encore éparpillés dans l'herbe du campus ». « Tout le monde est en colère, je ne comprends juste pas comment cela peut arriver », déclare un étudiant. La tuerie ravive aussi de douloureux souvenirs en Floride. Certains parents des victimes de la tuerie de Parkland, en 2018, ont désormais des enfants étudiants dans l'université de Tallahassee. « Mon cœur a lâché », décrit une mère de famille au Miami Herald, « c'était un effrayant 'déjà vu' ». Elle ajoute : « Arrêtez la politique et protégez nos enfants. On ne peut pas devenir insensible à ces tueries. On doit bien mieux à nos enfants ». À la Une du journal des Outre-mers, de notre partenaire La 1eLa Martinique commémore les 17 ans de la mort du penseur et écrivain Aimé Césaire.

Season FOUR Episode ELEVEN of the Your Story Our Fight® podcast welcomes Dr. Katherine VanHise. Katherine is an OBGYN and fertility specialist based in Beverly Hills, California.  Immediately following her graduation from OBGYN residency she developed her first symptoms of lupus.  Her diagnosis of SLE came 15 months later after consulting with over 20 physicians across different specialties and institutions.  Her journey navigating the health care system and a lupus diagnosis significantly transformed her personal and professional life.  She aspires to empower her patients and those around her to maintain hope in times of uncertainty and continually advocate for themselves.

Supporting Alabama's youth in agriculture— that's the goal of the Southeastern Livestock Exposition (SLE), and your ticket to the show contributes to that mission. SLE President Linwood McClain joins host Kayla Greer in studio to reflect on the SLE's history, its unique mission and share details about this year's event. Learn more at www.SLERodeo.com. 

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by the production of autoantibodies and immune complex formation, affecting multiple organ systems.While the exact etiology remains unclear, an integrative orthomolecular approach can provide insights into the root causes and intermediary mechanisms involved in SLE development and progression.This week George discussed the differences between the conventional approach to Lupus vs.a more integrative approach. 

This episode contains part 2 of our conversation with Michael Macklin, MD, PharmD, Assistant Professor of Medicine at the University of Chicago, about the Cytokine Crushers region of RheumMadness 2025.In this episode, we focus specifically on the TYK2 in SLE and Oral Anti-IL23 teams. Links to the Cytokine Crushers Scouting Reports:Oral anti-IL23, by collaborating Chicago area rheumatology fellowship programs (Loyola, Northwestern, and the University of Chicago)Long-term outcomes of anifrolumab in SLE, by the Medical University of South Carolina (MUSC) Adult Rheumatology FellowshipTYK2 inhibitor in SLE, by the University of North Carolina (UNC) Adult Rheumatology FellowshipLinks to theMednet.org Q&As about this region:What circumstances would drive you to consider using an oral IL-23 inhibitor over parenteral options for management of psoriasis/PsA?How will you utilize newly FDA approved anifrolumab for SLE in your practice?What is your experience with using oral deucravicitinib for conditions such as recalcitrant facial discoid lupus or recalcitrant lichen planus?To learn more about RheumMadness:https://sites.duke.edu/rheummadness/Subscribe to our newsletter:https://lists.duke.edu/sympa/subscribe/rheummadnessFind us on social media:Bluesky: @rheummadness.bsky.socialInstagram: https://www.instagram.com/rheummadness/X: Follow #RheumMadnessIntro/outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

QD Clinic 273 - ANA Negative Lupus https://youtu.be/g0W9aBRuDcQ     Pregnant ANA negative SLE (?) patients with Sjogrens and FM - what to do? QD274 - Undiagnosed Autoinflammatory https://youtu.be/hUkYi1gKJOM Autoinflammatory or Still's disease - does this matter? QD275 - Past DIagnoses https://youtu.be/1f4HYhvVGNA     When patients cling to a past diagnosis. QD Clinics - lessons from the clinic, sponsored by RNL2025 in Dallas, TX; Feb 8 & 9, 2025 Register at RheumNow.live

In this episode, we are joined by Michael Macklin, MD, PharmD, Assistant Professor of Medicine at the University of Chicago, to discuss the teams in the Cytokine Crushers region of RheumMadness 2025, the Innovation Invitational.This is part 1 of the conversation, where we go in depth about the long-term outcomes of anifrolumab in SLE study and give a primer about type 1/2 cytokines so you're ready to dig into the TYK2 in SLE and Oral Anti-IL23 studies.Join us again next week for part 2 of this discussion to learn more about this region.Links to the Cytokine Crushers Scouting Reports:Oral anti-IL23, by collaborating Chicago area rheumatology fellowship programs (Loyola, Northwestern, and the University of Chicago)Long-term outcomes of anifrolumab in SLE, by the Medical University of South Carolina (MUSC) Adult Rheumatology FellowshipTYK2 inhibitor in SLE, by the University of North Carolina (UNC) Adult Rheumatology FellowshipLinks to old scouting reports and other studies referenced in this podcast:TULIP 1/2 scouting report from RheumMadness 2021LLDAS scouting report from RheumMadness 2024Morand EF, Abreu G, Furie RA, Golder V, Tummala R. Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus. Ann Rheum Dis. 2023 May;82(5):639-645. doi: 10.1136/ard-2022-222748. Epub 2023 Jan 23. Erratum in: Ann Rheum Dis. 2024 Apr 11;83(5):e12. doi: 10.1136/ard-2022-222748corr1. PMID: 36690388; PMCID: PMC10176410.Tanaka Y. Viewpoint on anifrolumab in patients with systemic lupus erythematosus and a high unmet need in clinical practice. RMD Open. 2023 Aug;9(3):e003270. doi: 10.1136/rmdopen-2023-003270. Erratum in: RMD Open. 2024 Apr 4;10(2):e003270corr1. doi: 10.1136/rmdopen-2023-003270corr1. PMID: 37597847; PMCID: PMC10441065.ORAL Surveillance scouting report from RheumMadness 2024To learn more about RheumMadness:https://sites.duke.edu/rheummadness/Subscribe to our newsletter:https://lists.duke.edu/sympa/subscribe/rheummadnessFind us on social media:Bluesky: @rheummadness.bsky.socialInstagram: https://www.instagram.com/rheummadness/X: Follow #RheumMadnessIntro/outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/

In this episode we explore the role of Neutrophil Extracellular Traps (NETs) in systemic lupus erythematosus (SLE). Dr. Mariana Kaplan, Chief of the Systemic Autoimmunity Branch at the National Institute of Arthritis Musculoskeletal and Skin Diseases, joins the discussion to break down the complex immunological mechanisms driving lupus, focusing on the contribution of NETs and Low-Density Granulocytes (LDGs) to disease activity and tissue damage. The conversation delves into the potential for these biological markers to improve diagnosis and treatment strategies, particularly in the context of lupus flares and cardiovascular complications. A link to this week's article can be found, here: Exploring the Role of Neutrophil Extracellular Traps in Systemic Lupus Erythematosus: A Clinical Case Study and Comprehensive Review 

01/19/25The Healthy Matters PodcastS04_E07 - Let's Learn About Lupus!Did you know that in 2024, over 200,000 people in the U.S. alone had Lupus?  It's a condition that many of us have likely heard of, but it's one that often presents with a lot of questions - like where does it come from?  Who is most likely to get Lupus?  Is it a life-long condition?  And what help is available for those living with it?On the next episode of the show, we'll be joined by Rheumatologist, Dr. Rawad Nasr, and he'll help us get our brains around Lupus, as well as the basics of autoimmune diseases at large.  This is one condition that has seen a lot of progress in terms of treatments and medications over the past decade (finally!), so this is a great chance to get some up-to-date knowledge from an expert in the field.  He'll discuss the origins of the condition (and the name!), who's at risk, what help is available from the medical community, and ways we all can support those living with it.  Come get wise with us!We're open to your comments or ideas for future shows!Email - healthymatters@hcmed.orgCall - 612-873-TALK (8255)Get a preview of upcoming shows on social media and find out more about our show at www.healthymatters.org.

In this episode, we present the second part of our conversation with the authors of the scouting reports for the teams in the T'd Up T-cells region of RheumMadness 2025: the Innovation Invitational.  Plus, we highlight Q&As from theMednet.org about the T'd Up T-Cells teams AND record an interview with Dr. Bill St. Clair, the first author of the phase 2 dazodalibep study.  It's a long episode because there's so much content!Links to the Q&As from theMednet.org discussed in this episode:What is your approach to managing sicca symptoms in patients not responding or not tolerating conservative measures, pilocarpine, and cevimeline?What is your approach to immunomodulatory treatment in patients with Sjogren's syndrome who have active serologies (i.e. elevated ESR, hypergammaglobulinemia, hypocomplementemia) but minimal symptoms?What is your approach to monitoring patients referred for high titer +RF and +CCP but without active symptoms of inflammatory arthritis?What factors drive you to prioritize T vs B cell inhibition when choosing therapies for patients with refractory SLE?To learn more about RheumMadness:https://sites.duke.edu/rheummadness/Subscribe to our newsletter:https://lists.duke.edu/sympa/subscribe/rheummadnessFind us on social media:Bluesky: @rheummadness.bsky.socialInstagram: https://www.instagram.com/rheummadness/X: Follow #RheumMadnessIntro/outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/