Podcasts about galanin

***Scroll down discount code for Adipeau!*** In this bonus episode of the Healthy Skin Series, I'm talking with the founder of Adipeau, Ivan Galanin, all about why it's all about "achieving facial fitness." Trained as a scientist at a major biotech company, Ivan started two biotech companies--one to treat genetic disease, and one to treat cancer--Ivan then transitioned to aesthetics and face care when he realized how integral healthy facial fat is to aging. He's now founded Aeducator, a community to connect facial aesthetic practitioners with new ways of treating their clients. Adipeau is a brand that encourages the growth of new, healthy fat cells in the dermis, and in this episode we talk about the technology behind the brand as well as why Ivan thinks we have it all wrong when it comes to lasers, over-exfoliating and neuromodulators. We talk: + Why fat is a good thing for your face + There is no “super ingredient” for the skin + Should you ditch retinol? + Why you might want to reconsider lasers + The cause of “shiny” Botox skin + Can you really build collagen in the skin? + Repetitive wounding on the skin and its effects + What can you do to keep your fat “fit?” + Why he thinks scientific advancements mean we'll all be living longer soon For 15% off your order at Adipeau, use code SONNI15 at checkout! --- Support this podcast: https://podcasters.spotify.com/pod/show/wegottatalkwithsonni/support

This week's episode features Ivan Galanin, who founded Adipeau, a one-product-only brand that has developed a unique Active Face Cream to treat his skin concerns and struggles. The science behind this singular anti-aging product is fascinating, and Ivan shares his story with so much passion for his brand and business. We know you'll add his Face Cream to your cart before the end of this episode to ensure you age gracefully!  LINKS: Shop Adipeau: https://bskinenvie.ca/collections/adipeau SKNKRE IG BSE Instagram, Pinterest, Tiktok, Youtube Tasch's IG Beate's IG  Linktree can be found here. 

Noradrenaline (norepinephrine) is a neurotransmitter and hormone that plays a role in the body's "fight or flight" response.  Acetylcholine is a neurotransmitter (“brain” +” across” + “to send”) that helps transmit signals in the brain and body. Its name comes from its chemical structure, an acetate group and a choline molecule.  Dopamine is a neurotransmitter that plays a role in motivation, reward, and movement. Its name comes from its chemical structure, a combination of two molecules called dihydroxyphenylalanine and dopamine. Adrenaline (epinephrine) is a hormone and neurotransmitter that helps the body respond to stress. Its name comes from its source, the adrenal glands.  Serotonin is a neurotransmitter that is involved in mood, appetite, and sleep. Its name comes from its chemical structure, a combination of sero- (meaning "serum") and -tonin (meaning "tonic" or "substance that modifies").  Corticotropin-releasing hormone (CRH) is a hormone that stimulates the release of cortisol, a stress hormone. The name comes from its function of stimulating the release of corticotropin, a hormone that stimulates the adrenal glands. Also, it gets its name from its role in stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, which in turn stimulates the release of cortisol from the adrenal gland. Vasopressin is a hormone that regulates water balance in the body. Its name comes from its ability to constrict blood vessels (vasoconstriction) and increase blood pressure. Vasopressin, also known as antidiuretic hormone (ADH), is so named because it regulates water balance by causing the kidneys to reabsorb water. Thyrotropin-releasing hormone (TRH) is a hormone that stimulates the release of thyroid-stimulating hormone (TSH), which regulates the thyroid gland. Its name comes from its function of stimulating the release of thyrotropin.  Oxytocin is a hormone that is involved in social bonding, childbirth, and lactation. Its name comes from its ability to stimulate uterine contractions (oxytocic) and milk ejection (lactogenic).  Gonadotropin-releasing hormone (GnRH) is a hormone that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate the reproductive system. Its name comes from its function of stimulating the release of gonadotropins.  Growth hormone–releasing hormone (GHRH) is a hormone that stimulates the release of growth hormone (GH), which regulates growth and metabolism. Its name comes from its function of stimulating the release of growth hormone.  Catecholamines are a group of hormones and neurotransmitters that includes adrenaline, noradrenaline, and dopamine. Their name comes from their chemical structure, which includes a catechol group and an amine group.  Histamine is a neurotransmitter and hormone that is involved in inflammation, allergies, and gastric acid secretion. ACTH (adrenocorticotropic hormone) is a hormone that stimulates the release of cortisol from the adrenal glands.  Orexin (hypocretin) is a neurotransmitter that is involved in wakefulness and appetite. Its name comes from its discovery in the hypothalamus and its ability to stimulate food intake (orexigenic).  Glutamic acid (glutamate) is a neurotransmitter that is involved in learning, memory, and neural plasticity. Its name comes from its chemical structure, a combination of glutamine and an acid group.  Galanin is a neuropeptide that is involved in pain perception, mood, and appetite. Its name comes from its discovery in the galanin-containing neurons of the hypothalamus.  Neurotensin comes from the words "neuro," meaning related to nerves, and "tensin," which refers to its ability to cause contraction in smooth muscle. Neurotensin is a neuropeptide that is found in the central nervous system and gastrointestinal tract. --- Support this podcast: https://podcasters.spotify.com/pod/show/liam-connerly/support

Learn more at TheCityLife.org --- Send in a voice message: https://podcasters.spotify.com/pod/show/citylifeorg/message Support this podcast: https://podcasters.spotify.com/pod/show/citylifeorg/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.27.534088v1?rss=1 Authors: Higgs, M. J., Webberley, A. E., John, R. M., Isles, A. R. Abstract: Imprinted genes are subject to germline epigenetic modification resulting in parental-specific allelic silencing. Although genomic imprinting is thought to be important for maternal behaviour, this idea is based on serendipitous findings from a small number of imprinted genes. Here, we undertook an unbiased systems biology approach, taking advantage of the recent delineation of specific neuronal populations responsible for controlling parental care, to test whether imprinted genes significantly converge to regulate parenting behaviour. Using single-cell RNA sequencing datasets, we identified a specific enrichment of imprinted gene expression in a recognised 'parenting hub', the galanin-expressing neurons of the preoptic area. We tested the validity of linking enriched expression in these neurons to function by focusing on MAGE family member L2 (Magel2), an imprinted gene not previously linked to parenting behaviour. We confirmed expression of Magel2 in the preoptic area galanin expressing neurons. We then examined the parenting behaviour of Magel2+/- null mice. Magel2-null mothers, fathers and virgin females demonstrated deficits in pup retrieval, nest building and pup-directed motivation, identifying a central role for this gene in parenting. Finally, we show that Magel2-null mothers and fathers have a significant reduction in POA galanin expressing cells, which in turn contributes to a reduced c-Fos response in the POA upon exposure to pups. Our findings identify a novel imprinted gene that impacts parenting behaviour and, moreover, demonstrates the utility of using single-cell RNA sequencing data to predict gene function from expression and in doing so here, have identified a purposeful role for genomic imprinting in mediating parental behaviour. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In episode 9, we had a great time chatting with Nicholas Galanin and hearing about his artistic and musical endeavors including carving totem poles and being part of this year's Awk Rock Indigenous Music Festival! Hope you enjoy!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.04.510783v1?rss=1 Authors: Lenschow, C., Mendes, A. P., Ferreira, L., Lacoste, B., Quilgars, C., Bertrand, S. S., Lima, S. Q. Abstract: During sex, male arousal increases up to the ejaculatory threshold, allowing genital sensory input to trigger ejaculation. While copulation and arousal increase are thought to be centrally regulated, ejaculation is a reflex controlled by a spinal circuit, whose activity is strongly inhibited by descending input from the brain, bearing no role on the regulation of sexual behavior up until the arousal threshold. However, this hypothesis remains untested. To tackle this problem, we combined genetic approaches with electrophysiological and behavioral analysis to functionally map the spinal circuit controlling the main muscle involved in sperm expulsion, the bulbospongiosus muscle (BSM). We found that BSM motor neurons (BSM-MNs) receive direct synaptic input from a group of galanin-expressing (Gal+) interneurons located in the upper lumbar spinal cord. Furthermore, the Gal+ population is progressively activated during sexual behavior and receives genital sensory input. Electrical and optogenetic activation of the Gal+ neurons evoked activity in BSM-MNs and BSM after spinalization. Interestingly, these effects were dependent on the behavioral state of the male and drastically decreased with repeated stimulation. Moreover, genetic ablation of the Gal+ neurons severely impacted the latency to ejaculate and the structure of the copulatory sequence. Taken together, our results imply an unexpected involvement of the spinal cord in the control of copulatory behavior, sexual arousal and in the post-ejaculatory refractory period, in addition to its well established role in ejaculation. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Examining the complexities of contemporary Indigenous identity, culture, and representation, Nicholas Galanin works from his experience as a Tlingit and Unangax̂ artist. Embedding incisive observation and reflection into his oftentimes provocative work, he aims to redress the widespread misappropriation of Indigenous visual culture, the impact of colonialism, as well as collective amnesia. Galanin reclaims narrative and creative agency, while demonstrating contemporary Indigenous art as a continually evolving practice. As he describes: “My process of creation is a constant pursuit of freedom and vision for the present and future. I use my work to explore adaptation, resilience, survival, dream, memory, cultural resurgence, and connection and disconnection to the land.” Galanin unites both traditional and contemporary practices, creating a synthesis of elements in order to navigate “the politics of cultural representation.” Speaking through multiple visual, sonic, and tactile languages, his concepts determine his processes, which include sculpture, installation, photography, video, performance, and textile-based work. This contemporary practice builds upon an Indigenous artistic continuum while celebrating the culture and its people; Galanin contributes urgent criticality and vision through resonant and layered works. The online viewing room at Peter Blum can be seen here. Nicholas Galanin (b. 1979, Sitka, Alaska) earned a BFA at London Guildhall University (2003), an MFA at Massey University, Palmerston North, New Zealand (2007), and apprenticed with master carvers and jewelers. He currently lives and works with his family in Sitka, Alaska. Galanin participated in Desert X, Palm Springs (2021); Biennale of Sydney (2020); Venice Biennale (2017); Whitney Biennial (2019); and Honolulu Biennial (2019). Galanin's work is in permanent collections including The Museum of Modern Art, New York; Whitney Museum of American Art, New York; Philadelphia Museum of Art; Art Institute of Chicago; The Phillips Collection, Washington, D.C.; Art Bridges, Bentonville, AR; Detroit Institute of Arts; The National Gallery of Canada, Ottawa; The Museum of Fine Arts, Houston; Denver Art Museum; Los Angeles County Museum of Art; Princeton University among others. He received an award from American Academy of Arts and Letters (2020) and received a Soros Arts Fellowship (2020). Loom, 2022 prefab children's school desks and chairs with graphite and pencil carving, 100 x 83 x 54 inches (254 x 210.8 x 137.2 cm) World Clock, 2022 monotype on paper and accumulating stacks of The New York Times installation: dimensions variable monotype: 30 x 22 1/2 inches (76.2 x 57.1 cm) The New York Times: 11 1/4 x 12 inches, each

Nicholas Galanin is the force behind musical projects Ya Tseen, Indian Agent, and Silver Jackson. Based out of Sitka, Alaska, he creates art – both musical and physical – from and for his Tlingit community. Continuum is core to Galanin's being. Being of both Tlingit and Unangax̂ heritage, Galanin's work is concerned with serving his community and creating space for their voices, art, and culture in a world that has intentionally tried to strip it away. His collaborations as part of the Black Constellation represent an important statement of solidarity between Black and Indigenous artistic communities. In this episode, we journey with Galanin through his numerous musical projects, his HomeSkillet festival and label, and some of his various exhibits and large scale art installations, like the “Never Forget” piece that saw him placing the words “INDIAN LAND” in Palm Springs in the style of the Hollywood sign. Galanin's work is a mirror to the past while reflecting toward the future. Listen to a playlist of music from the episode and read the transcript on KEXP.org. Support the show: https://www.kexp.org/fresh **If you're in the Seattle area or want to make the trip, you can join KEXP at Clock-Out Lounge on Friday, May 27 for "Fresh Off The Spaceship Live." The event will feature performances from Black Constellation artists Shabazz Palaces, Stas THEE Boss, Porter Ray and more. You can find more information on KEXP.org and buy tickets here. Support the show: https://www.kexp.org/fresh See omnystudio.com/listener for privacy information.

Episode No. 540 features curator Judith W. Mann and artist Nicholas Galanin. Mann is the curator of "Paintings on Stone: Science and the Sacred, 1530-1800," which is on view at the Saint Louis Art Museum through May 15. (Mann was assisted by Andrea Miller.) The exhibition, which includes more than 70 works by 58 artists, is the first examination of the pan-European practice of painting on stones such as lapis lazuli, slate and marble. The exhibition is accompanied by a terrific catalogue. Indiebound and Amazon offer it for about $50. On April 7-8 SLAM will be presenting a virtual symposium that explores painting on stone and the role that stone played in the meaning of individual artworks. The symposium is free but requires Zoom registration. Nicholas Galanin's work is on view in "The Scene Changes: Sculpture from the Sheldon's Collection" at the Sheldon Museum of Art at the University of Nebraska, Lincoln. The Sheldon acquired Galanin's 2012 The American Dream is Alie and Well in 2020. Galanin's work has been the subject of solo shows at Davidson College, the BYU Museum of Art, the Montclair Art Museum, the Missoula Art Museum, the Anchorage Museum and more. In 2018 The Heard Museum in Phoenix presented a survey of Galanin's career. Later this year the Weatherspoon Art Museum at the University of North Carolina Greensboro and the Crystal Bridges Museum of American Art in Bentonville, Ark. will present exhibitions of Galanin's work. Galanin is a Tlingit and Unangax̂ artist whose work examines contemporary Indigenous identity, culture and representation and interrogates the routine misappropriation of Native culture, colonialism and collective amnesia.

Preston Singletary (Tlingit) has a new album coming out with his band Khu.éex. He also has a traveling exhibition of his glass artwork, heading next to the National Museum of the American Indian. And his design for a public work of art was chosen to be installed outside Seattle's Climate Pledge Arena. Nick Galanin is […]

Preston Singletary (Tlingit) has a new album coming out with his band Khu.éex. He also has a traveling exhibition of his glass artwork, heading next to the National Museum of the American Indian. And his design for a public work of art was chosen to be installed outside Seattle's Climate Pledge Arena. Nick Galanin is […]

Preston Singletary (Tlingit) has a new album coming out with his band Khu.éex. He also has a traveling exhibition of his glass artwork, heading next to the National Museum of the American Indian. And his design for a public work of art was chosen to be installed outside Seattle's Climate Pledge Arena. Nick Galanin is another busy artist with one-man shows all over the globe. He also has a new album of his music out. They are among several Native multidisciplinary artists who draw inspiration and support from their culture and each other to keep their creativity thriving.

Activist, thinker, contemporary artist, and musician Nicholas Galanin entwines his experience as an Alaskan indigenous person and passion for social and environmental justice with falling in love and the birth of a child for his debut album as Ya Tseen. Titled Indian Yard, the record is a collaboration between himself and the many artists that see Galanin as a friend including Otis Calvin III (who you might know as OC Notes), Benjamin Verdoes, Shabazz Palaces, Nick Hakim, fellow Indigenous Alaskan singer and songwriter Qacung, and Alaska's biggest rock stars Portugal. The Man. Recorded 07/05/2021. Knives Close the Distance A Feeling Undefined Light the Torch At Tugáni Watch the full Live on KEXP session on YouTube Support the show: https://www.kexp.org/donate See omnystudio.com/listener for privacy information.

Activist, thinker, contemporary artist, and musician Nicholas Galanin entwines his experience as an Alaskan indigenous person and passion for social and environmental justice with falling in love and the birth of a child for his debut album as Ya Tseen. Titled Indian Yard, the record is a collaboration between himself and the many artists that see Galanin as a friend including Otis Calvin III (who you might know as OC Notes), Benjamin Verdoes, Shabazz Palaces, Nick Hakim, fellow Indigenous Alaskan singer and songwriter Qacung, and Alaska's biggest rock stars Portugal. The Man. Recorded 07/05/2021. Knives Close the Distance A Feeling Undefined Light the Torch At Tugáni Watch the full Live on KEXP session on YouTube Support the show: https://www.kexp.org/donate See omnystudio.com/listener for privacy information.

Newsletter: https://dralkapatel.com/mailinglist “How does temperature affect sleep?” Season 7 Episode 5 My guest on this week's episode of The Lifestyle First Podcast is Tara Youngblood. Tara is the co-founder of Chilli Sleep and a TEDx speaker with TEDx CaryWomen with the talk, “How a sleep recipe changed my life.” We discuss the sleep switch activated by temperature We reflect on hunter-gatherer research and natural outdoor temperature dips compared to current day climate control We talk about the connection between sleep and stress We look at how digestion and metabolic processes generate heat that can disrupt sleep We also discuss cryotherapy and ice baths 1. The one question we discuss is “How does temperature affect sleep?” 2. The two references we look at are: · Kroeger, D. et al. Galanin neurons in the venterolateral preoptic area promote sleep and heat loss in mice. Nature Communications. 2018. (9): 4129 https://www.nature.com/articles/s41467-018-06590-7 · Yetish, g. e tal. Natural Sleep and its seasonal variations in three pre-industrial societies. Current biology. 2015.25 (21): 2862-2868 https://www.cell.com/current-biology/fulltext/S0960-9822(15)01157-4 3. The three actions to take are · Manage stress – take stress checks throughout the day · Set yourself up for success for sleep · Get sunlight by 9am Which of these 3 actionable health tips will you implement? Leave your comments below. -x- Join The Lifestyle First Academy! Take the flagship course – Start Now: Transform your Lifestyle, Transform your Life https://dralkapatel.com/academy/ -x- DISCLAIMER: This content does not constitute or substitute personal one-to-one professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or health care professional with questions about your health. -x- Find Out More/Contact/Follow: Guest: Tara Youngblood TEDx Talk https://youtu.be/YR-lWXZ7ZUg Website https://chilisleep.co.uk/ Product Discounts 30% off Cube system https://www.chilisleep.com/discount/PATEL-30?redirect=%2Fproducts%2Fcube-sleep-system 20% off Ooler system https://www.chilisleep.com/discount/PATEL-20?redirect=%2Fproducts%2Fooler-sleep-system Social https://www.facebook.com/ChiliSleep/ https://www.instagram.com/the_sleep_geek/ https://twitter.com/tlcnyoungblood?lang=en https://www.linkedin.com/in/tara-youngblood-88469514/ Host: Dr Alka Patel TEDx talk https://youtu.be/JpFLNk3_Qik Newsletter: https://dralkapatel.com/mailinglist Website: https://dralkapatel.com/ --- Send in a voice message: https://anchor.fm/dr-alka-patel/message

Ya Tseen - "Knives (feat. Portugal. The Man)" from the 2021 album Indian Yard on Sub Pop. Originally from Sheet'ka (Sitka, Alaska), artist Nicholas Galanin brings the influence of his Tlingit and Unangax̂ heritage to his spacey dance pop. Under the name Ya Tseen (which simultaneously translates to “be alive” and references his Tlingit name Yeil Ya Tseen), he uses his music to advocate for "Indigenous sovereignty, racial, social, and environmental justice, for present, and future generations." Today's Song of the Day is not about weaponry, but surrender. In a press release, Galanin shares, "“Knives is a love song about softening a calloused heart and experiencing the edge of magnetic desire, romantic connection, vulnerability, and risk that love opens us up to.” The song features guest vocals from John Baldwin Gourley of fellow Alaska-formed band Portugal. the Man, who he considers "friends and allies for social and environmental justice." Read the full post on KEXP.org Support the show: https://www.kexp.org/donate See omnystudio.com/listener for privacy information.

Over the last 3 years, Nicholas Galanin and Otis Calvin III have been making Indian Yard, the debut record from the project Ya Tseen on Sub Pop records.  We hear how the two veteran collaborators made the record both remotely and in person,  the importance of both processes and why trust, generosity and patience made the project flow.  They also discuss why "back to normal" may not be a good thing for everyone and why we need to take a break from  the internet and engage in in-person as soon as possible.  Music by Ya Tseen and Joe PlummerEpisode sponsored by Izotope, Izotope.com and Caddis, Caddislife.com

Musician and artist Nicholas Galanin joins Dwyer to talk about land acknowledgment, leaving Alaska to live in London as a young man, and his pursuit of music. Openings Song, "Knives," by Ya Tseen from the album Indian YardNicholas's website HERE Landback GOFundMe HERERead more about Landback: All funds raised will go towards repatriating land back to Indigenous communities and to support the LandBack movement, to continue the acquisition of land titles for Indigenous nations to have legal standing under U.S.law to protect traditional territories. The LandBack movement is a regenerative, sustainable effort to center Indigenous knowledge and repair damages done to land and all people living here. The impacts of invasion, colonization, settlement and forced assimilation continue to have multi-generational impact upon us all. These impacts are varied, they are experienced differently and disproportionately, evident on the land and water, the changing climate and ecosystems. Reparations for what has been forcibly taken from Indigenous Nations must be grounded in ceding land; to end occupation and begin coexistence, with Indigenous leadership, to return to healthy and regenerative relationship with land. Buy Ya Tseen HERE Conversations With Dwyer is Recorded, Produced,& Hosted by Matt DwyerAll Things Dwyer HERE See acast.com/privacy for privacy and opt-out information.

A new musical project led by Sitka-based Nicholas Galanin has signed with legendary SubPop records. “Close the Distance” is the first single off the debut album for Ya Tseen, the latest project from... Visit knba.org/news to get more information.

Ivan received his scientific training in inflammation research at sanofi. Before he started Adipeau, he founded two successful companies. Plexcera Therapeutics developed a treatment for a rare pediatric genetic disease (Farber Disease). When Ivan started Plexcera, there was only one living patient with Farber. He sold the company to a large public biotech company. After Plexcera, he started MyPersonalTherapeutics, which identified patient-specific drug combinations for colon cancer. The company built genetically complex fruit fly avatars representing individual human cancers and conducted massive clinical studies in the fruit flies. Both companies were spun out of Mount Sinai School of Medicine, where Ivan had worked as Director of Commercial Development. Ivan is now dedicated to researching how the remarkable regenerative powers of the skin can be harnessed to advance facial and whole body fitness. He was recently published in a notable peer reviewed journal, Aesthetic Plastic Surgery. He is also committed to increasing the level of scientific understanding amongst skincare consumers. --- Send in a voice message: https://anchor.fm/skincareanarchy/message

Každý máme v hlavě unikátní neurochemický koktejl, bez kterého by mozek a naše subjektivní realita nefungovaly. Jednou z těch důležitých látek je i neurohormon noradrenalin, který hraje ústřední roli v bdělosti a pozornosti a je vytvářen jedním centrem zvaným locus coeruleus. Ve dnešním dílu vám osvětlíme jak jedno jádro v mozku ovlivňuje spoustu činností, které denně vykonáme. Jak je ovlivňován stres s pozorností v mozku? Co s námi dělá zírání na obzor? Co je to molekula galanin a jak nám pomáhá? Jak si můžeme galanin navýšit? Proč v názvu podcastu píšeme o římanech? To vše se dozvíte ve dnešním detailním dílu. Přejeme příjemný poslech! Sledujte Brain We Are na sociálních sítích: Instagram nebo Facebook Podpořte nás jednorázově nebo na startovači Pořiďte si náš kurz průvodce suplementy Zadej kód "BWA" pro 10% slevu na UpLife.cz "Tento podcast slouží pouze pro vzdělávací účely. Neberte informace v něm zmíněné jako lékařskou radu" Studie: https://www.jneurosci.org/content/40/39/7464 Poznámky k dílu: Co je to galanin • Neuropeptid zapleten do stresu se týkajících neuropsychiatrických onemocnění, úzkosti, deprese a poruchy nálad jak v lidech, tak zvířatech • Na tahle onemocnění neexistuje efektivní lék, přitom se ukazuje, že fyzická akvitia pomáhá podobně, jako nejlepší dostupné intervence • Locus Coeruleus je v těchto onemocnění dysregulován • Fyzická aktivita ho aktivuje • Galanin se ve vysokém množství nachází v LC a při fyzické aktivitě se zvyšuje jeho množství Studie: • Nejdříve zkoumali, jak cvičení zvedá galanin a odolnost vůči stresu (měření úzkostného chování na základě elektrického šoku) • Poté měli geneticky upravenou myš, u které byl pouze zvýšený galanin, bez fyzické aktivity! Dostavilo se stejné zvýšení odolnosti vůči stresu! Ale důležité je, že se neměnili další aspekty chování • A naposledy optogeneticky stimulovalo LC a sledovali, co to udělá s myší a jejím úzkostlivým chováním i přes zvýšený galanin a ukázalo se, že byl stále vůči stresu odolná • Tahle studie dokazuje, že je to galain, který mediuje, neboli zprostředkovává zvýšenou odolnost vůči stresu a snížené úzkostné chování Minutáž: 01:40 - Slovní hříčka 02:50 - Noradrenalin a jádro bdělosti v mozku 08:50 - Snížení kreativity a kognitivní flexibility na základě stresu 11:20 - Uklidnění a zírání na obzor 14:00 - Co s námi dělá pohled na obzor? 17:10 - A zase to centrum noradrenalinu ! Co všechnod dělá? 18:00 - Galanin : Neuropeptid pro snížení stresu 22:00 - Fascinující optogenetika a aktivace mozku na dálku! 25:00 - Shrnutí Galaninu 26:30 - Co udělat pro zvýšení galaninu v mozku?

My interview with artist, musician, and founder of HomeSkillet Records out of Sitka, Alaska, Nicholas Galanin. Nicholas (Yéil Ya-Tseen) shares his experiences with family during covid, his new album in progress, and collaborating remotely. We also discuss the theme of Indigenous erasure in his art and the album designs for his label and band Indian Agent.NICHOLAS GALANIN:@nicholasgalaninhttps://galan.in/https://homeskilletrecords.bandcamp.com/Carry a Song / Disrupt an Anthemhttps://www.vulture.com/2020/06/nicholas-galanin-shadow-on-the-land.htmlhttps://www.peterblumgallery.com/news/nicholas-galanin-interviewed-by-casey-grove-for-alaska-public-mediahttps://www.nytimes.com/2020/07/16/arts/design/art-galleries-reopen-nyc.htmlFollow on IG @designfreakspodcastTwitter @designfreakspodFacebook https://www.facebook.com/designfreakspodcastdesignfreakspodcast.comRuinousmedia.comDonate to help with recording costs Thank you!Theme Music: "Jet in Jungle" by Damaged Bug, courtesy of John DwyerOther Music: “If You Saw the Fire” by Indian Agent, courtesy of Nicholas Galanin

My interview with Tlingit/Unangax̂ artist, musician, and founder of HomeSkillet Records out of Sitka, Alaska, Nicholas Galanin. Nicholas (Yéil Ya-Tseen) shares his experiences with family during covid, his new album in progress, and collaborating remotely. We also discuss the theme of Indigenous erasure in his art and the album designs for both his label and his band Indian Agent––––––Support the show (https://www.venmo.com/Clarita-Hinojosa)

This episode I am SO Honored to welcome artist and activist Nicholas galanin (Yéil Ya-Tseen - Tlingit/Unangax -he/him) we talk about his rise to being one of the most sought after artists in the country and world. He has been most recently in the news for pulling his work out of the famed Whitney museum to protest the racist behavior of a board member and even last week photos of his "Shadow on the Land, an excavation in bush burial" - a literal excavated show cast of the Captain James Cook statue in Sydney Australia - which the image went viral as monuments around the world were taken down by protest.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.24.060608v1?rss=1 Authors: Tillage, R. P., Wilson, G. E., Liles, L. C., Holmes, P. V., Weinshenker, D. Abstract: The neuropeptide galanin has been implicated in stress-related neuropsychiatric disorders in both humans and rodent models. While pharmacological treatments for these disorders are ineffective for many individuals, physical activity is beneficial for stress-related symptoms. Galanin is highly expressed in the noradrenergic system, particularly the locus coeruleus (LC), which is dysregulated in stress-related disorders and activated by exercise. Galanin expression is elevated in the LC by chronic exercise, and blockade of galanin transmission attenuates exercise-induced stress resilience. However, most research on this topic has been done in rats, so it is unclear whether the relationship between exercise and galanin is species-specific. Moreover, use of intracerebroventricular galanin receptor antagonists in prior studies precluded defining a causal role for LC-derived galanin specifically. Therefore, the goals of this study were twofold. First, we investigated whether physical activity (chronic voluntary wheel running) increases stress resilience and galanin expression in the LC of mice. Next, we used transgenic mice that overexpress galanin in noradrenergic neurons (Gal OX) to determine how chronically elevated noradrenergic-derived galanin, alone, alters anxiogenic-like responses to stress. We found that three weeks of ad libitum access to a running wheel in their home cage increased galanin mRNA in the LC of mice and conferred resilience to a stressor. The effects of exercise were phenocopied by galanin overexpression in noradrenergic neurons, and Gal OX mice were resistant to the anxiogenic effect of optogenetic LC activation. Together, these findings support a role for chronically increased noradrenergic galanin in mediating resilience to stress. Copy rights belong to original authors. Visit the link for more info

From mice to primates to humans, Harvard University's Catherine Dulac provides a fascinating account of research that reveals the specific factors in the brain that govern parenting behavior that are shared by all mammals. Series: "Women in Science" [Science] [Show ID: 31761]

From mice to primates to humans, Harvard University's Catherine Dulac provides a fascinating account of research that reveals the specific factors in the brain that govern parenting behavior that are shared by all mammals. Series: "Women in Science" [Science] [Show ID: 31761]

From mice to primates to humans, Harvard University's Catherine Dulac provides a fascinating account of research that reveals the specific factors in the brain that govern parenting behavior that are shared by all mammals. Series: "Women in Science" [Science] [Show ID: 31761]

From mice to primates to humans, Harvard University's Catherine Dulac provides a fascinating account of research that reveals the specific factors in the brain that govern parenting behavior that are shared by all mammals. Series: "Women in Science" [Science] [Show ID: 31761]

"Culture cannot be contained as it unfolds. My art enters this stream at many different points, looking backwards, looking forwards, generating its own sound and motion. I am inspired by generations of Tlingit & Unangax̂ creativity and contribute to this wealthy conversation through active curiosity. There is no room in this exploration for the tired prescriptions of the "Indian Art World" and its institutions. Through creating I assert my freedom. Concepts drive my medium. I draw upon a wide range of indigenous technologies and global materials when exploring an idea. Adaptation and resistance, lies and exaggeration, dreams, memories and poetic views of daily life--these themes recur in my work, taking form through sound, texture, and image. Inert objects spring back to life; kitsch is reclaimed as cultural renewal; dancers merge ritual and rap. I am most comfortable not knowing what form my next idea will take, a boundless creative path of concept- based motion." - Nicholas Galanin

"Culture cannot be contained as it unfolds. My art enters this stream at many different points, looking backwards, looking forwards, generating its own sound and motion. I am inspired by generations of Tlingit & Unangax̂ creativity and contribute to this wealthy conversation through active curiosity. There is no room in this exploration for the tired prescriptions of the "Indian Art World" and its institutions. Through creating I assert my freedom. Concepts drive my medium. I draw upon a wide range of indigenous technologies and global materials when exploring an idea. Adaptation and resistance, lies and exaggeration, dreams, memories and poetic views of daily life--these themes recur in my work, taking form through sound, texture, and image. Inert objects spring back to life; kitsch is reclaimed as cultural renewal; dancers merge ritual and rap. I am most comfortable not knowing what form my next idea will take, a boundless creative path of concept- based motion." - Nicholas Galanin

In this episode of Stories From The Land we hear an incredible story of survival and rebirth from Tlingit/Aleut artist Nicholas Galanin. Raised closely to the land and tied intricately to it through his dynamic, boundary pushing and revolutionary multi-medium art practice, this is a story of reconcilliation with the land when the land nearly takes life away from us. This is a poweful story of survival and the endless limitations of the human spirit.