Podcasts about Tasuku Honjo

Dr. James Allison is the Regental Professor and Chair of the Department of Immunology, Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, Executive Director of the Immunotherapy Platform, and Director of the James P. Allison Institute at MD Anderson Cancer Center. Dr. Allison has spent a distinguished career studying the regulation of T cell responses and developing strategies for cancer immunotherapy. He earned the 2018 Nobel Prize in Physiology or Medicine, which he shared with Dr. Tasuku Honjo, "for their discovery of cancer therapy by inhibition of negative immune regulation." His current work seeks to improve immune checkpoint blockade therapies currently used by clinicians and identify new targets to unleash the immune system in order to eradicate cancer. He talks about the hunt for the T cell receptor and working to bring CTLA-4 blockade into the clinic. He also discusses what's next for immunotherapy, including future investigations into myeloid cells, and playing the harmonica in a band.

3 March 2022 - In the November 1992 issue of The EMBO Journal, Tasuku Honjo and colleagues reported the discovery of a new gene, which they named programmed death 1 (PD-1). Thirty years later, monoclonal antibodies against PD-1 were being used in the clinic to treat cancer patients, and in 2018 Tasuku Honjo shared the Nobel Prize for Physiology or Medicine with James Allison. “The paper has been transformational. I don't think that they would ever have predicted that looking into genes that were differentially expressed that they would get such an important molecule that would be transformative for cancer immunotherapy,” said EMBO Journal Chief Editor Facundo Batista. In this episode of the EMBO podcast, Tasuku Honjo spoke about his journey from medical school to basic research, the importance of academic journals, and the many surprising turns in the PD-1 story. We also talked to Pierre Golstein, whose group cloned CTLA-4.

La lucha contra el cáncer se ha basado tradicionalmente en tres pilares: la cirugía, la quimioterapia y la radioterapia. Pero desde hace unos años contamos con una nueva estrategia: la inmunoterapia, la posibilidad de que sea nuestro propio organismo el que acabe con las células tumorales. En 2018, los inmunólogos James Allison y Tasuku Honjo ganaron el premio Nobel de Medicina por descubrir cómo activar el sistema inmunitario para combatir el cáncer, un cambio de paradigma en medicina que no ha hecho más que empezar. Alternativas en este campo como linfocitos T receptores de antígenos quiméricos o células CAR-T, están generando interesantes resultados. Hace unas semanas conocíamos el caso de dos pacientes que sufrían un tipo de leucemia que ya no respondía a los tratamientos. Ambos fueron los primeros en someterse a la que entonces era una nueva terapia celular, CAR-T, y diez años después, no presentan signos de enfermedad y las células siguen funcionando. Con la colaboración de Lluis Montoliu, investigador del CNB-CSIC, hemos entrevistado al doctor Antonio Pérez-Martínez, jefe del Servicio de Hemato-Oncología Pediátrica del hospital La Paz de Madrid. En nuestro recorrido por la Historia de la ciencia, Nuria Martínez Medina ha trazado el perfil de Valmont de Bomare. Este naturalista francés escribió una influyente enciclopedia de historia natural en la década de 1760. Leyre Flamarique nos ha hablado de la plataforma de cribado de nuevos fármacos contra la COVID impulsada por el Centro Nacional de Biotecnología, con testimonios de Pablo Gastaminza y Urtzi Garaigorta, investigadores principales del proyecto. Hemos informado de la concesión del premio BBVA Fronteras del Conocimiento en la modalidad de Ciencias Básicas a los matemáticos Charles Fefferman y Jean-François Le Gall por sus contribuciones fundamentales en el análisis matemático y en la teoría de la probabilidad. Álvaro Martínez del Pozo nos ha hablado de la molécula exenátida, un veneno que produce el lagarto conocido como monstruo de Gila (Heloderma suspectum) que se emplea en el tratamiento de la diabetes. Eulalia Pérez Sedeño nos ha acercado a la biografía de Joaquina Eguaras, la primera licenciada en Filosofía y Letras de la universidad de Granada y la primera docente en esta institución. Fue también profesora de árabe y hebreo y directora del museo arqueológico de Granada. Hemos reseñado los libros "Historias del mundo de las hormigas", de Edward Osborne Wilson (Crítica); "¿Qué es el nuevo Sistema Internacional de Unidades de medida", de Dolores del Campo y Miguel Ángel Martín Delgado (Catarata); "De pajareo. Rutas ornitológicas por España", de Javier Sandoval (GeoPlaneta); y "Extinciones. El crepúsculo de las especies", de Jean-Baptiste de Panafieu y Alexandre Franc (Garbuix Books). Escuchar audio

In 2018, the Nobel Prize in Physiology or Medicine was awarded jointly to Dr James Allison and Dr Tasuku Honjo, for their work in immunotherapy, which led to a breakthrough in developing new cancer treatments. Both researchers were recognised for work they had begun in the 1990s, which shows the arduous, yet rewarding, process of research and scientific discovery. In this show, we take a macro look at how research has moved the needle in urological cancer care. We get Professor Dr Ng Chirk Jenn, the Deputy Dean of Research from the Faculty of Medicine at the University of Malaya, to share UM’s research on urological cancers, while Prof Dr Ong Teng Aik, Consultant Urologist from Universiti Malaya Medical Centre, continues the conversation on how research improves prevention and treatment of these cancers. Image Source: Shutterstock

In 2018, the Nobel Prize in Physiology or Medicine was awarded jointly to Dr James Allison and Dr Tasuku Honjo, for their work in immunotherapy, which led to a breakthrough in developing new cancer treatments. Both researchers were recognised for work they had begun in the 1990s, which shows the arduous, yet rewarding, process of research and scientific discovery. In this show, we take a macro look at how research has moved the needle in urological cancer care. We get Professor Dr Ng Chirk Jenn, the Deputy Dean of Research from the Faculty of Medicine at the University of Malaya, to share UM’s research on urological cancers, while Prof Dr Ong Teng Aik, Consultant Urologist from Universiti Malaya Medical Centre, continues the conversation on how research improves prevention and treatment of these cancers. Image Source: Shutterstock

Sunday, September 13, 2020“God’s Love Endures Forever”Psalm 1361. God, the creator* Tasuku Honjo (2018 Nobel Prize in Physiology or Medicine winner)* Tim White (UCLA Professor)* Genesis 1:1 “beginning” = time, “heaven” = space, “earth” = ma..

2018 Nobel Prize Winner Dr. Tasuku Honjo established an entirely new principle for cancer therapy. Follow his journey as he worked to unlock a new discovery, using our own immune system to fight one of humanity’s greatest health challenges. See acast.com/privacy for privacy and opt-out information.

Ali lahko bakterijska okužba pozdravi tumor? Kako sprostiti zavore imunskega odziva, da se bo učinkovito spopadal z rakom? O ozadju Nobelove nagrade za medicino, ki sta si jo za leto 2018 delila James P. Allison in Tasuku Honjo.

This past year brought us a lot of awareness of new cancer treatments making a difference in people's lives. The Nobel Prize for medicine went to a pair of scientists for their work on cancer. The discoveries of Dr. James Allison and Dr. Tasuku Honjo led to new ways to treat cancer by targeting the body's immune system rather than cancerous tumors themselves. Peter Loftus, Reporter for the WSJ, joins us to talk about the impact of their work in the fight to cure cancer. Next, one of the more bizarre stories to hit the news. It was the story of 11 malnourished children found in a compound in New Mexico. It was weird to begin with, but then took a turn. According to prosecution documents, the remains of a boy were found and the man who is at the center of it all was allegedly training one of the children in the use of an assault rifle in preparation for a future school shooting. National Security analyst Ryan Mauro, joins us for more on this story. Finally, one of the big jerks of the year was a man known as the “dine and dash dater.” He was finally caught after years on the prowl. Paul Gonzales would meet women on dating apps, take them out, order a robust dinner, and then leave and never come back, forcing the women to pay a huge bill. Lauren Strapagiel, reporter for Buzzfeed News, joins us for how much jail time he is facing and what was in all those dinner orders. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

Dr. Uttiya Basu discusses a 1999 paper by the group of Tasuku Honjo that demonstrates a critical role for activation-induced cytidine deaminase in class switch recombination and somatic hypermutation of B cells.

Los premios Nobel de Ciencias de 2018 son protagonistas hoy en Ciencia Fresca. James P. Allison y Tasuku Honjo, galardonados con el Nobel de Fisiología y Medicina, han merecido el premio por su descubrimiento de una terapia antitumoral basada en la inhibición de la regulación inmunitaria negativa. El premio Nobel de Física ha sido para Arthur Ashkin, por el desarrollo de pinzas ópticas y sus aplicaciones a los sistemas biológicos, y para Gérard Mourou y Donna Strickland, por el desarrollo del método para generar pulsos láser ultra cortos y de gran intensidad. Por último, hablamos del Premio Nobel de Química, concedido a Frances H. Arnold, por su evolución dirigida de las enzimas y a George P. Smith y Sir Gregory P. Winter por el “pantallazo de bacteriófagos”.

Dette er en spesialinnspilling om årets Nobelpris i medisin eller fysiologi som i år går til de to forskerne James P. Allison fra USA og Tasuku Honjo fra Japan. De får den for sin oppdagelse av hvordan immunsystemet kan styres for å finne og drepe kreftceller i kroppen- de såkalte sjekkpunkthemmerne. I studio har vi med oss Steinar Aamdal og Gustav Gaudernack som har hatt møter med Allison en rekke ganger, senest i fjor. Til tross for at Aamdal og Gaudernack er over 70 år begge to, så jobber de med å utvikle kreftvaksiner i Radforsk sitt porteføljeselskap Ultimovacs. Vi snakker om dette, hva en Nobelpris til immunterapi mot kreft betyr for Radforsk og porteføljen, og vi dykker ned i immunterapien og den fascinerende biologien i immunforsvaret. Hør og les også: Science Talk - Unleashing Immunity against Cancer: Nobel Prize in Physiology or Medicine: https://www.acast.com/sciencetalk/unleashing-immunity-against-cancer-nobel-prize-in- New York Times – 2018 Nobel Prize in Medicine Awarded to 2 Cancer Immunotherapy Researchers https://www.nytimes.com/2018/10/01/health/nobel-prize-medicine.html

Paolo e Valeria conducono la puntata 224 di Scientificast.Siamo reduci dalla settimana dei Nobel, dove sono stati assegnati anche quest’anno molti importanti riconoscimenti a ricerche altrettanto interessanti. Ne abbiamo parlato approfonditamente nel nostro blog e in particolare in questi articoli:– Nobel per la Medicina e la Fisiologia 2018 a James P. Allison e Tasuku Honjo, per le loro scoperte sull’attivazione del sistema immunitario che hanno gettato le basi per l’immunoterapia contro il cancro.– Nobel per la Fisica 2018 a Arthur Ashkin (1/2) a Gérard Mourou e Donna Strickland (1/2) per le loro innovative invenzioni nel campo della fisica dei laser. In questa puntata parliamo approfonditamente di questo premio con Chiara Trovatello, dottoranda presso il Dipartimento di Fisica del Politecnico di Milano.– Nobel per la Chimica 2018 a Frances H. Arnold (1/2) per “l’evoluzione diretta degli enzimi” e a George P. Smith e Sir Gregory P. Winter (1/2) per “lo sviluppo della tecnica phage display di peptidi e anticorpi”.Nella seconda parte della puntata, Marco Casolino, Giuliana Galati e Silvia Kuna Ballero aprono l’angolo della polemica riguardo il talk del prof. Strumia che ha tanto indignato il mondo della ricerca (e non solo!) con le sue affermazioni sessiste.Come sempre vi invitiamo, se lo vorrete, a concorrere alle spese di produzione del nostro podcast sostenendo l’Associazione di Promozione Sociale Scientificast mediante Patreon.

Earlier this week, on the 1st of October 2018 to be exact, two wonderful people have been awarded the Nobel Prize for Medicine or Physiology: James Allison and Tasuku Honjo. CONGRATULATIONS! These two men have more or less invented immunotherapy through their early experiments in the nineties, through which drugs like Keytruda, Opdivo and Yervoy […]

“The Nobel Assembly at Karolinska Institute has today decided to award the 2018 Nobel Prize in Physiology or Medicine, jointly to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation.”Thomas Perlmann, secretary of the Nobel Assembly shortly after 5:30 this morning Eastern time.“James P. Allison was born in Alice, in Texas, in the United States. He performed his prize-winning studies at the University of California, Berkeley, and at Memorial Sloan Kettering Cancer Center in New York. He is now active at The University of Texas M. D. Anderson Cancer Center in Houston. Tasuku Honjo was born in Kyoto, in Japan. He performed his prize-winning studies at Kyoto University, where he is still active.”Karolinska Institute immunologist Klas Kärre, a member of the Nobel Committee, explained the significance of the work of the new Nobel laureates:“Allison's and Honjo's discoveries have added a new pillar in cancer therapy. It represents a completely new principle, because unlike the previous strategies it is not based on targeting the cancer cells, but rather the brakes, the checkpoints, of the host immune system. The seminal discoveries by the two laureates constitute a paradigmatic shift and a landmark in the fight against cancer.”For an in-depth listen about the 2018 Nobel Prize in Physiology or Medicine, look for the Scientific American Science Talk podcast later today.—Steve Mirsky[The above text is a transcript of this podcast.]

Wenn Aufmerksamkeit die neue Währung des Digitalzeitalters ist, dann ist der Populist ohne Zweifel der Aufsteiger der Saison. Deshalb im Interview: ein bekennender Provokateur und Nonkonformist, Schweizer Nationalratsmitglied und Verleger der „Weltwoche“ – Roger Köppel. Er diagnostiziert in Deutschland „eine gespenstische Gleichförmigkeit“: Meinungsvielfalt sei durch Meinungseinfalt ersetzt worden. Viele unserer Berufskollegen, meint er, hätten ihren Beruf verfehlt: „Sie sind Partei geworden, denken nicht vor, sondern plappern nach.“ Außerdem: Der diesjährige Medizin-Nobelpreis geht an zwei Krebsforscher aus den USA und Japan, James Allison und Tasuku Honjo. Geehrt werden sie für ihre Arbeiten zur Aktivierung des Immunsystems gegen Krebszellen. Was genau haben die diesjährigen Preisträger erforscht und wie helfen sie damit Patienten? Diese Frage geht an Prof. Dietger Niederwieser, bis vor kurzem Chef der Onkologie am Uniklinikum Leipzig.

It is Nobel Prize time and this year the award for medicine goes to a pair of scientists for their work on cancer. The discoveries of Dr. James Allison and Dr. Tasuku Honjo led to new ways to treat cancer by targeting the body's immune system rather than cancerous tumors themselves. Peter Loftus, Reporter for the WSJ, joins us for the latest Nobel Prize winners and the impact of their work in the fight to cure cancer. Next, Goodbye NAFTA, hello USMCA! The US, Canada, and Mexico have just agreed to update NAFTA after more than a year of intense negotiations. The deal has a new name, new rules for auto makers, still doesn't take care of current steel and aluminum tariffs, and sets up the next battle with figuring out our trade disputes with China. Megan Casella, trade reporter for Politico, joins us for what's in the deal and the potential fight with Congress to get it all approved. Finally, it has been a whirlwind of news for Elon Musk and Tesla. The Securities and Exchange Commission sued Musk for tweets related to taking Tesla private. Musk caved and now he has to pay $20M, step down as chairman, and hire a lawyer to approve any tweets he sends out related to the company. Ben Geman, Energy Reporter at Axios, joins us on the Elon Musk roller coaster. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

“The Nobel Assembly at Karolinska Institute has today decided to award the 2018 Nobel Prize in Physiology or Medicine, jointly to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation.”Thomas Perlmann, secretary of the Nobel Assembly shortly after 5:30 this morning Eastern time.“James P. Allison was born in Alice, in Texas, in the United States. He performed his prize-winning studies at the University of California, Berkeley, and at Memorial Sloan Kettering Cancer Center in New York. He is now active at The University of Texas M. D. Anderson Cancer Center in Houston. Tasuku Honjo was born in Kyoto, in Japan. He performed his prize-winning studies at Kyoto University, where he is still active.”Karolinska Institute immunologist Klas Kärre, a member of the Nobel Committee, explained the significance of the work of the new Nobel laureates:“Allison's and Honjo's discoveries have added a new pillar in cancer therapy. It represents a completely new principle, because unlike the previous strategies it is not based on targeting the cancer cells, but rather the brakes, the checkpoints, of the host immune system. The seminal discoveries by the two laureates constitute a paradigmatic shift and a landmark in the fight against cancer.”For an in-depth listen about the 2018 Nobel Prize in Physiology or Medicine, look for the Scientific American Science Talk podcast later today.—Steve Mirsky[The above text is a transcript of this podcast.]

El premio Nobel de Medicina este año ha señalado los trabajos de James Allison y Tasuku Honjo, que han permitido abrir un nuevo frente en la lucha contra el cáncer: la inmunoterapia. La mayoría de los tratamientos contra el cáncer se dirigen directamente contra los tumores: los atacan, los debilitan y, en última instancia, los hacen desaparecer. Pero es difícil eliminar todas y cada una de las células de un tumor, y si unas pocas se escapan pueden volver a proliferar. La inmunoterapia explora otro enfoque: animar al sistema inmune para que sea él, que tiene muchos más recursos que nosotros, el que localice y elimine al tumor. En condiciones normales el sistema inmune cumple esta función sin necesidad de que le digamos nada, pero algunos tipos de cáncer se especializan en "esconderse" del sistema inmune, o en desactivarlo cuando éste se dispone a atacar. En estos casos la inmunoterapia puede ser una herramienta extremadamente útil. Si os interesa saber más sobre el sistema inmune y cómo se está usando para luchar contra el cáncer escuchad los episodios s05e26, s06e14 y s01e32. Este programa se emitió originalmente el 1 de octubre de 2018. Podéis escuchar el resto de audios de La Brújula en su canal de iVoox y en la web de Onda Cero, ondacero.es

James P. Allison and Tasuku Honjo share the Nobel Prize for their work on harnessing the cancer patient's own immune system to destroy tumors.

James P. Allison and Tasuku Honjo share the Nobel Prize for their work on harnessing the cancer patient's own immune system to destroy tumors.

Deze week worden de Nobelprijzen uitgereikt. De eerste, de Nobelprijs voor de Geneeskunde, ging naar James Allison en Tasuku Honjo voor hun onderzoek naar immuuntherapie. Medisch redacteur Sander Voormolen schuift aan en vertelt over deze vierde pijler in kankerbestrijding (naast operaties, bestraling en chemotherapie).De winnaars van de Nobelprijzen voor Natuurkunde en Chemie worden respectievelijk dinsdag en woensdag bekend gemaakt. Ook die zullen de Onbehaarde Apen in een bonusaflevering bespreken. Abonneer je om niets te missen!Benieuwd naar waarom het winnende onderzoek zo bijzonder is of heb je een andere vraag? Mail ons op podcast@nrc.nl.Presentatie: Lucas Brouwers en Gemma VenhuizenProductie: Mirjam van Zuidam@lucasbrouwers // @hendrikspiering // @SanderVoormolen

James P. Allison and and Tasuku Honjo shared the Nobel Prize for their discovery of inhibition of negative immune regulation, the basis of new drugs against cancer.

Die britischen Konservativen sind auf ihrem Parteitag in Birmingham vor allem mit einer Frage beschäftigt: Wer gewinnt im Streit um den Brexit? Premierministerin Theresa May streitet mit der EU über ihren Brexit-Plan, das hat ihre Gegner innerhalb der Tories um Ex-Außenminister Boris Johnson gestärkt. Wie kann es jetzt weitergehen? Rieke Havertz spricht darüber mit Marcus Gatzke, Ressortleiter Politik, Wirtschaft und Gesellschaft bei ZEIT ONLINE. Die Medizinnobelpreise sind bereits vergeben, Physik und Chemie stehen in der Wissenschaft noch aus. Ob die Krebsforscher James P. Allison und Tasuku Honjo zu Recht ausgezeichnet wurden und ob es in der Physik und Chemie Favoriten für die Nobelpreise gibt, darüber sprechen wir mit Alina Schadwinkel, Wissensredakteurin bei ZEIT ONLINE. Mitarbeit: Jaakko Kacsóh

Genom att släppa på det egna immunförsvarets bromsar har årets Nobelpristagare funnit ett revolutionerande sätt att behandla cancer. James Allison och Tasuku Honjo får årets Nobelpris i medicin för deras upptäckt av cancerbehandling genom hämning av immunförsvarets bromsmekanismer. I programmet hörs Olle Kämpe, professor i klinisk endokrinologi. Annika Östman & Katarina Sundberg vet@sverigesradio.se