Podcast appearances and mentions of Thomas Sanders

In a decision that has sparked widespread outrage, President Joe Biden has commuted the death sentences of 37 federal inmates, converting their punishments to life imprisonment without parole. This action, taken just weeks before the conclusion of his presidency and the inauguration of President-elect Donald Trump, has drawn fierce criticism from victims' families, advocacy groups, and members of the public. The commutations include individuals convicted of some of the most heinous crimes imaginable, including child murders, mass killings, and other acts of unimaginable violence. Critics argue that this move undermines justice, dishonors the memories of the victims, and raises serious questions about Biden's judgment as he approaches the twilight of his political career. Among those spared the death penalty is Thomas Sanders, a man convicted of the brutal kidnapping and murder of a 12-year-old girl. Sanders' crime not only ended a young life but also shattered a family, leaving scars that will never fully heal. His actions were so egregious that they drew national attention, with many calling for the harshest possible punishment. By commuting his sentence, Biden has effectively nullified the jury's decision to impose the ultimate penalty, sparking outrage among those who believe justice was already served. Another individual whose sentence was commuted is Anthony Battle, a man convicted of killing a prison guard. Battle's actions demonstrated a complete disregard for human life and authority, further highlighting the danger he posed to society. His crime, committed in a setting meant to rehabilitate or at least contain individuals who have broken the law, is a chilling reminder of the violence that can occur even in the most secure environments. By removing the possibility of execution, Biden's decision has reopened wounds for the families of the victims and those affected by his crime. The list of commuted sentences includes other names that are synonymous with terror and heartbreak. Marvin Gabrion, for example, was found guilty of the murder of Rachel Timmerman, whom he bound and drowned in a lake, leaving her infant daughter motherless. Kaboni Savage, a drug kingpin, orchestrated a firebombing that killed six people, including four children, as an act of witness intimidation. These are not isolated incidents or cases of wrongful conviction; these are cold, calculated acts of violence that tore families apart and left communities reeling. Yet, these individuals will now spend the rest of their lives in prison rather than face the ultimate punishment decreed by a jury of their peers. For the families of the victims, Biden's decision is a betrayal. These are families who have already endured unimaginable loss and have fought tirelessly for justice. The commutations feel like a dismissal of their pain and a disregard for the lives that were brutally taken. One father of a victim, speaking on the condition of anonymity, described the decision as “an insult to the memory of my child and a slap in the face to our family.” Another grieving family member questioned how someone convicted of such heinous acts could be shown mercy when they offered none to their victims. The emotional toll on these families cannot be overstated. Many have spent years attending court proceedings, reliving their trauma in the pursuit of justice. For them, the death penalty represented not only a punishment for the perpetrators but also a form of closure, a definitive end to a chapter marked by pain and loss. Biden's decision to commute these sentences has reopened old wounds and left many feeling that their suffering has been compounded by the very system they trusted to deliver justice. Critics of the decision have also pointed to Biden's age and alleged cognitive decline as factors that may have influenced this controversial move. At 82 years old, Biden has faced increasing scrutiny over his mental fitness for office. Reports have surfaced suggesting that White House aides have taken extraordinary measures to manage his schedule and public appearances, sparking concerns about his ability to make sound decisions on matters of such gravity. Some have described his recent public performances as “faltering” and “concerning,” likening them to those of a “grandfather who should be enjoying retirement rather than leading a nation.” The timing of the commutations has only added fuel to the fire. Coming just weeks before President-elect Donald Trump—a vocal advocate for expanding the use of the death penalty—takes office, the decision is seen by many as a last-minute effort to cement a legacy on criminal justice reform. Trump has made no secret of his intentions to resume federal executions and has even called for the death penalty in cases involving drug dealers and other violent criminals. By commuting these sentences, Biden has effectively tied the hands of the incoming administration, setting the stage for a potential clash over capital punishment policies. The broader implications of this decision extend beyond the individuals whose sentences were commuted. It has reignited the national debate over the death penalty, a deeply polarizing issue in American society. Advocates for capital punishment argue that it serves as a deterrent to crime and a necessary tool for delivering justice in the most egregious cases. Opponents, on the other hand, cite concerns about wrongful convictions, the high costs associated with death penalty cases, and the moral questions surrounding state-sanctioned executions. Biden's commutations have also drawn criticism from advocacy groups that support victims' rights. These organizations have long argued that the death penalty is not only a form of justice but also a way to honor the lives of the victims. By sparing the lives of those who have committed unspeakable acts, critics say Biden has sent a message that undermines the gravity of their crimes and the suffering they caused. In contrast to the backlash, Biden's supporters argue that the decision is consistent with his long-standing opposition to the death penalty. During his 2020 presidential campaign, Biden pledged to work toward ending federal executions and incentivizing states to follow suit. His administration imposed a moratorium on federal capital punishment in 2021 to review the protocols used, effectively halting executions during his term. However, even some of his supporters acknowledge that the commutations go beyond the scope of his campaign promises, particularly given the severity of the crimes involved. The political ramifications of this decision are significant. With public opinion on the death penalty evenly split—53% of Americans support it, according to recent polls—Biden's actions risk alienating a substantial portion of the electorate. For a president whose approval ratings have fluctuated throughout his term, this controversial move could have lasting impacts on his legacy and the Democratic Party's standing on criminal justice issues. Biden's commutations also come on the heels of other controversial acts of clemency. Earlier this month, he commuted the sentences of approximately 1,500 individuals who were released from prison and placed on home confinement during the COVID-19 pandemic, as well as 39 others convicted of nonviolent crimes. While these actions were praised by some as a step toward criminal justice reform, they have also been criticized as overly lenient. Adding to the controversy, Biden recently pardoned his son, Hunter Biden, for federal gun and tax charges, a move that has sparked political uproar and allegations of favoritism. The cumulative effect of these decisions has cast a shadow over Biden's final days in office. As he prepares to leave the White House, questions about his judgment, priorities, and legacy loom large. For many, the commutations of these federal death row inmates represent a tipping point, a decision that will define his presidency for better or worse. For the families of the victims, however, the focus remains on the loss they have endured and the justice they feel has been denied. As one grieving mother put it, “We trusted the system to hold these monsters accountable. Now, it feels like that trust has been shattered.” As the nation grapples with the implications of this decision, one thing is clear: the debate over capital punishment is far from over. Whether Biden's commutations will ultimately be seen as a step toward a more humane justice system or a grave misstep remains to be seen. For now, the controversy surrounding this decision serves as a stark reminder of the complexities and consequences of executive power in the United States. Want to listen to ALL of our podcasts AD-FREE? Subscribe through APPLE PODCASTS, and try it for three days free: https://tinyurl.com/ycw626tj Follow Our Other Cases: https://www.truecrimetodaypod.com The latest on The Downfall of Diddy, The Trial of Karen Read, The Murder Of Maddie Soto, Catching the Long Island Serial Killer, Awaiting Admission: BTK's Unconfessed Crimes, Delphi Murders: Inside the Crime, Chad & Lori Daybell, The Murder of Ana Walshe, Alex Murdaugh, Bryan Kohberger, Lucy Letby, Kouri Richins, Malevolent Mormon Mommys, The Menendez Brothers: Quest For Justice, The Murder of Stephen Smith, The Murder of Madeline Kingsbury, The Murder Of Sandra Birchmore, and much more! Listen at https://www.truecrimetodaypod.com 

In a decision that has sparked widespread outrage, President Joe Biden has commuted the death sentences of 37 federal inmates, converting their punishments to life imprisonment without parole. This action, taken just weeks before the conclusion of his presidency and the inauguration of President-elect Donald Trump, has drawn fierce criticism from victims' families, advocacy groups, and members of the public. The commutations include individuals convicted of some of the most heinous crimes imaginable, including child murders, mass killings, and other acts of unimaginable violence. Critics argue that this move undermines justice, dishonors the memories of the victims, and raises serious questions about Biden's judgment as he approaches the twilight of his political career. Among those spared the death penalty is Thomas Sanders, a man convicted of the brutal kidnapping and murder of a 12-year-old girl. Sanders' crime not only ended a young life but also shattered a family, leaving scars that will never fully heal. His actions were so egregious that they drew national attention, with many calling for the harshest possible punishment. By commuting his sentence, Biden has effectively nullified the jury's decision to impose the ultimate penalty, sparking outrage among those who believe justice was already served. Another individual whose sentence was commuted is Anthony Battle, a man convicted of killing a prison guard. Battle's actions demonstrated a complete disregard for human life and authority, further highlighting the danger he posed to society. His crime, committed in a setting meant to rehabilitate or at least contain individuals who have broken the law, is a chilling reminder of the violence that can occur even in the most secure environments. By removing the possibility of execution, Biden's decision has reopened wounds for the families of the victims and those affected by his crime. The list of commuted sentences includes other names that are synonymous with terror and heartbreak. Marvin Gabrion, for example, was found guilty of the murder of Rachel Timmerman, whom he bound and drowned in a lake, leaving her infant daughter motherless. Kaboni Savage, a drug kingpin, orchestrated a firebombing that killed six people, including four children, as an act of witness intimidation. These are not isolated incidents or cases of wrongful conviction; these are cold, calculated acts of violence that tore families apart and left communities reeling. Yet, these individuals will now spend the rest of their lives in prison rather than face the ultimate punishment decreed by a jury of their peers. For the families of the victims, Biden's decision is a betrayal. These are families who have already endured unimaginable loss and have fought tirelessly for justice. The commutations feel like a dismissal of their pain and a disregard for the lives that were brutally taken. One father of a victim, speaking on the condition of anonymity, described the decision as “an insult to the memory of my child and a slap in the face to our family.” Another grieving family member questioned how someone convicted of such heinous acts could be shown mercy when they offered none to their victims. The emotional toll on these families cannot be overstated. Many have spent years attending court proceedings, reliving their trauma in the pursuit of justice. For them, the death penalty represented not only a punishment for the perpetrators but also a form of closure, a definitive end to a chapter marked by pain and loss. Biden's decision to commute these sentences has reopened old wounds and left many feeling that their suffering has been compounded by the very system they trusted to deliver justice. Critics of the decision have also pointed to Biden's age and alleged cognitive decline as factors that may have influenced this controversial move. At 82 years old, Biden has faced increasing scrutiny over his mental fitness for office. Reports have surfaced suggesting that White House aides have taken extraordinary measures to manage his schedule and public appearances, sparking concerns about his ability to make sound decisions on matters of such gravity. Some have described his recent public performances as “faltering” and “concerning,” likening them to those of a “grandfather who should be enjoying retirement rather than leading a nation.” The timing of the commutations has only added fuel to the fire. Coming just weeks before President-elect Donald Trump—a vocal advocate for expanding the use of the death penalty—takes office, the decision is seen by many as a last-minute effort to cement a legacy on criminal justice reform. Trump has made no secret of his intentions to resume federal executions and has even called for the death penalty in cases involving drug dealers and other violent criminals. By commuting these sentences, Biden has effectively tied the hands of the incoming administration, setting the stage for a potential clash over capital punishment policies. The broader implications of this decision extend beyond the individuals whose sentences were commuted. It has reignited the national debate over the death penalty, a deeply polarizing issue in American society. Advocates for capital punishment argue that it serves as a deterrent to crime and a necessary tool for delivering justice in the most egregious cases. Opponents, on the other hand, cite concerns about wrongful convictions, the high costs associated with death penalty cases, and the moral questions surrounding state-sanctioned executions. Biden's commutations have also drawn criticism from advocacy groups that support victims' rights. These organizations have long argued that the death penalty is not only a form of justice but also a way to honor the lives of the victims. By sparing the lives of those who have committed unspeakable acts, critics say Biden has sent a message that undermines the gravity of their crimes and the suffering they caused. In contrast to the backlash, Biden's supporters argue that the decision is consistent with his long-standing opposition to the death penalty. During his 2020 presidential campaign, Biden pledged to work toward ending federal executions and incentivizing states to follow suit. His administration imposed a moratorium on federal capital punishment in 2021 to review the protocols used, effectively halting executions during his term. However, even some of his supporters acknowledge that the commutations go beyond the scope of his campaign promises, particularly given the severity of the crimes involved. The political ramifications of this decision are significant. With public opinion on the death penalty evenly split—53% of Americans support it, according to recent polls—Biden's actions risk alienating a substantial portion of the electorate. For a president whose approval ratings have fluctuated throughout his term, this controversial move could have lasting impacts on his legacy and the Democratic Party's standing on criminal justice issues. Biden's commutations also come on the heels of other controversial acts of clemency. Earlier this month, he commuted the sentences of approximately 1,500 individuals who were released from prison and placed on home confinement during the COVID-19 pandemic, as well as 39 others convicted of nonviolent crimes. While these actions were praised by some as a step toward criminal justice reform, they have also been criticized as overly lenient. Adding to the controversy, Biden recently pardoned his son, Hunter Biden, for federal gun and tax charges, a move that has sparked political uproar and allegations of favoritism. The cumulative effect of these decisions has cast a shadow over Biden's final days in office. As he prepares to leave the White House, questions about his judgment, priorities, and legacy loom large. For many, the commutations of these federal death row inmates represent a tipping point, a decision that will define his presidency for better or worse. For the families of the victims, however, the focus remains on the loss they have endured and the justice they feel has been denied. As one grieving mother put it, “We trusted the system to hold these monsters accountable. Now, it feels like that trust has been shattered.” As the nation grapples with the implications of this decision, one thing is clear: the debate over capital punishment is far from over. Whether Biden's commutations will ultimately be seen as a step toward a more humane justice system or a grave misstep remains to be seen. For now, the controversy surrounding this decision serves as a stark reminder of the complexities and consequences of executive power in the United States. Want to listen to ALL of our podcasts AD-FREE? Subscribe through APPLE PODCASTS, and try it for three days free: https://tinyurl.com/ycw626tj Follow Our Other Cases: https://www.truecrimetodaypod.com The latest on The Downfall of Diddy, The Trial of Karen Read, The Murder Of Maddie Soto, Catching the Long Island Serial Killer, Awaiting Admission: BTK's Unconfessed Crimes, Delphi Murders: Inside the Crime, Chad & Lori Daybell, The Murder of Ana Walshe, Alex Murdaugh, Bryan Kohberger, Lucy Letby, Kouri Richins, Malevolent Mormon Mommys, The Menendez Brothers: Quest For Justice, The Murder of Stephen Smith, The Murder of Madeline Kingsbury, The Murder Of Sandra Birchmore, and much more! Listen at https://www.truecrimetodaypod.com

Paul Harvey - Thomas Sanders

Listen to the rest with a 7 day free trial at our Patreon!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Download the DoorDash app and enter code PITREDDIT to get 50% off your first order (up to a $20 value) and zero delivery fees. Thomas is here to read some of the most wholesome Reddit stories we could find! 0:00-1:51 Intro 1:52-8:58 Took my daughter's bf out to dinner https://www.reddit.com/r/AmITheAngel/comments/15djhur/aita_for_being_the_most_wholesome_person_on_earth/ 8:59-18:49 I talk to my wife's dead husband https://www.reddit.com/r/TrueOffMyChest/comments/1172rdy/i_talk_to_the_dead_first_husband_of_my_wife_and/ 18:50-25:28 I called my brother a silly goose https://www.reddit.com/r/AmItheAsshole/comments/11u10iq/aita_for_calling_my_brother_a_silly_goose_to_his/ 25:29-32:24 I didn't want to pressure my niece https://www.reddit.com/r/AmItheAsshole/comments/uhde21/aita_for_telling_my_soontobe_niece_that_she/ 32:25-33:24 Sponsors! 33:25-38:46 I fell in love with my rival https://www.reddit.com/r/TrueOffMyChest/comments/x4xhb2/i_fell_in_love_with_my_rival/ 38:47-46:15 I'm gay and my wife doesn't know https://www.reddit.com/r/TrueOffMyChest/comments/15lttv4/im_gay_and_my_wife_doesnt_know/ 46:16-57:37 I just realized the sacrifices my brother made for us https://www.reddit.com/r/TrueOffMyChest/comments/104ror5/i_f18_realized_all_the_sacrifices_my_older/ 57:38-1:05:30 My gf confessed to me that she fakes it https://www.reddit.com/r/relationship_advice/comments/15c50jr/my_girlfriend_24f_just_confessed_to_me_26m_that/ 1:05:31-1:16:39 I used my wife's hair dryer...down there https://www.reddit.com/r/AmItheAsshole/comments/t5a9jr/aita_for_using_my_wifes_400_hair_dryer_on_my_nards/?utm_source=share&utm_medium=ios_app&utm_name=iossmf WEAR OUR JOKES: https://smosh.com WHO YOU HEAR Shayne Topp // https://www.instagram.com/shaynetopp/ Angela Giarratana // https://www.instagram.com/giovanagiarratana/ Thomas Sanders ( @ThomasSanders  ) // https://www.instagram.com/thomassanders/ WHO YOU DON'T HEAR (usually) Director: Courtney Miller Editor: Rock Coleman Director of Programming, Smosh Pit: Kiana Parker Associate Producer, Smosh Pit: Kimmy Jimenez Assistant Director: Amanda Barnes Art Director: Cassie Vance Assistant Art Director: Erin Kuschner Art Coordinator: Alex Aguilar Audio Mixer: Greg Jones Dir Of Photography: Brennan Iketani Dir, Design: Brittany Hobbs Designer: Ness Cardano Dir, Social Media & Marketing: Rachel Evans DIT/AE: Matt Duran Post Production Manager: Luke Baker Production, EVP: Zoe Moacanin Production Manager: Amanda Barnes Production Coord: Heidi Ha Production Assistant: Marcus Munguia Senior Manager, Channel & Strategy: Lizzy Jones Talent Coordinator: Selina Garcia OTHER SMOSHES: Smosh: https://smo.sh/Sub2Smosh Smosh Games: https://smo.sh/Sub2SmoshGames El Smosh (Spanish Dub): https://smo.sh/Sub2ElSmosh SmoshCast: https://smo.sh/Sub2SmoshCast FOLLOW US: TikTok: https://smo.sh/TikTok Snapchat: http://smo.sh/OnSnapchat Instagram: https://instagram.com/smosh Facebook: https://facebook.com/smosh Twitter: https://twitter.com/smosh"

What happens when our worldviews are shaped by external influences? How does the power of storytelling drive marketing? Step into an enlightening conversation with our special guest, Thomas Sanders-Corridan, as we navigate truth in today's media landscape, explore the potency of language in child upbringing and emphasize the need for conscious awareness of our surroundings. Let's venture into the concept of 'marking time' and its impact on our lives and relationships. We'll also consider a healthier approach to ending relationships, fondly termed 'conscious uncoupling'.Delve into an exploration of charity funding, non-profit compensation, and the concept of 'social coin' - a term that might just redefine societal norms. The discussion swings into the often overlooked need for male solidarity, addressing the rising tide of male suicides, and the necessity of sustainable for-profit businesses. Alongside, we'll acquaint you with the different types of warriors, their strengths, and Thomas Sanders Corden's unique concept of leadership influence.We wrap up with an overview of Thomas Sanders-Corridan' new service for dads in business, as we reflect on the significance of male solidarity and the urgency of establishing sustainable for-profit businesses. The conversation includes the power of our circles of influence, the importance of studying a craft, the metrics used to determine a charity's effectiveness, the implications of 'social coin', and the different warrior types. Join us on this enlightening journey as we challenge norms, encourage conversation, and inspire change!Connect with Thomas Sanders-Corridan HERE!! Click the HERE to choose your path! Click HERE to choose your path! Support the showBook a one-on-one with Rick YeeClick HERE to schedule a free 30-minute consultation if you'd like support to take the right step towards the great life you deserve.⭐Thank you for listening to our podcast! We would greatly appreciate it if you could take a moment to give us a 5-star review. Your support helps us reach more listeners and continue to bring you high-quality content. Thank you!For more information on The Warrior's Way program, and upcoming events click here

Thomas Sanders(17-year-old Piano Prodigy) stops by the SuperTalk Studio to talk about how he found his love for the piano and how his style has been inspired by the late, great Jerry Lee Lewis.

Thomas Sanders(17-year-old Piano Prodigy) stops by the SuperTalk Studio to talk about how he found his love for the piano and how his style has been inspired by the late, great Jerry Lee Lewis.

Paul Harvey - Thomas Sanders

The wonderful Thomas Sanders joins us this week and we are obsessed with him! He brought us some riddles formats to solve from HRR past and the four of us contemplate the troubled existence of the guy from operation. Why is his nose like that!?! Why isn't he getting better? Starring: Adal Rifai John Patrick Coan Erin Keif Editing by:  Casey Toney The wonderful Thomas Sanders joins us this week and we are obsessed with him! He brought us some riddles formats from HRR past and the four of us contemplate the troubled existence of the guy from operation. Why is his nose like that!?! Why isn't he getting better? Theme by:  Arne Parrott Logo by:  Emily Kardamis & Emmaline Morris Want more? Get Weekly Bonus Eps on Patreon! Want merch? Visit our TeePublic Store! or pins, buttons & prints Want to mail us something?  Hey Riddle Riddle  6351 W Montrose Ave #267 Chicago, IL, 60634 Want to leave us a voicemail? Call (805) RIDDLE-1 or (805-743-3531) Want to advertise on the show? Check out Hey Riddle Riddle via Gumball.fmSee omnystudio.com/listener for privacy information.

'Twas the night before Wintertide and all through the Bottom's up the gang is excitedly awaiting the arrival of the magical Tinsel Todd (Thomas Sanders). Will Tinsel Todd bring them gifts or will he piss in their shoes? Will they learn the true meaning of Wintertide?  Starring: Erin Keif, Waleed Mansour, Elizabeth Andrews, Sean Coyle, and Ben Briggs. Guest Star: Thomas Sanders Theme Song by Arne Parrott Artwork and Story Concept by Waleed Mansour Story Concept Also by Sean Coyle Edited by Sean Meagher Chilax Holiday LIVE SHOW link  Follow us on Twitter, Instagram, & TikTok: @SitcomDnD Advertise on SitcomD&D via Gumball.fm Support our Patreon at Patreon.com/Sitcomdnd Like the show? Rate SitcomD&D 5 stars on Apple Podcasts and leave a review.See omnystudio.com/listener for privacy information.

You can see the Thomas Sanders video channel at the following link: https://youtube.com/c/ThomasSanders

Created by Free FM, Hamilton, New Zealand

Listen to the rest at our Patreon! See omnystudio.com/listener for privacy information.

The Cast & Crew listen to Poetix and his plan, and meet their brand new companion in halting the Forged progression, B.R.A.D. played by Thomas Sanders!ENTER OUR GUEST ADVENTURER CONTEST FOR YOUR CHANCE TO WIN AWESOME THOMAS SANDERS & CAST PARTY PRIZES! Dice, Merch, and so much more! CLICK HERE!Follow Thomas on Twitter, Instagram, and TikTok and be sure to check out his BRAND NEW DND Series, Roleslaying With Roman!Join the Cast & Crew and support the show directly over on Patreon!Snag your very own Cast Party Merch HERE!Follow us on TikTok, Twitter, and Instagram!Business Email: castpartydnd@gmail.comColin (Director) - @DirectorColinRyan (Sebastian) - @Ry.McManusAnna (Blueberry) - @BrizzyVoicesNigel (Xander) - @NigelSuckslolVince (Jett) - @JettAndPebbles

In honor of our newest Special Guest, Thomas Sanders, catch up on the show with this quick Recap of Episodes 31-36!

The Tooth Fairy has been hit by inflation. Peleton & Operation Tin Man. A visit with Leiha White with Aggieland Humane. Thomas Sanders with Bryan Parks & Rec stops by. Masks & vaccine mandates are loosening. Law & Order returns! Litter on Mars?

This week the incredible Thomas Sanders joins us to discuss the Macaulay Culkin classic: The Pagemaster. FOLLOW US ZACH - TWITTER // INSTAGRAM KELSEY - TWITTER // INSTAGRAM GARRICK - TWITTER // INSTAGRAM Learn more about your ad choices. Visit podcastchoices.com/adchoices

Thank you all for listening to this episode of the podcast! Today's artist was Thomas Sanders. Our email is goodmorninguintah@gmail.com, our website is https://goodmorninguintah.wordpress.com Thank you to Anchor for sponsoring the podcast! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/woodrow-snow/message

De nieuwe Omgevingswet treedt naar verwachting op 1 januari 2022 in werking. De overheid wil met de Omgevingswet de regels voor ruimtelijke ontwikkelingen vereenvoudigen en samenvoegen. De nieuwe wet moet zorgen voor meer openheid, samenhang en flexibiliteit in ruimtelijk beleid. In deze aflevering praten wij met Thomas Sanders, advocaat/partner bij AKD N.V., over deze wet.... Het bericht Afl. 53: De nieuwe Omgevingswet verscheen eerst op AboutLaw.

Thomas Sanders is a photographer who shoots for a wide variety of clients, from Esquire magazine to senior living communities. A professor of photography at the Savannah College of Art and Design, Sanders is also the author of two photography books, "The Last Good War: The Faces and Voices of WWII” was published by Welcome Books in 2010.As the winner of the 2010 Foreword Reviews' Book of the Year Award for Editor's Choice Nonfiction as well as a selection of The History Book Club and The Military Book Club, this collection of portraits was called “meticulously rendered and brilliantly lit” by the Chicago Tribune. In 2020, Sanders published his second book, “Vietnam War Portraits: The Faces and Voices.”Topics of Discussion:Overview on my journey of doing films and photo shoots for senior living companiesHow to represent seniors in marketing: Some companies want realistic residents and some want seniors that are younger than their resident age demographicPhotos and films for baby boomers are going to become more modern and hip, how do boomers want to be perceived?How to pick senior stock photos?A few tips on how employees can take good social media photos of residentsThomas' Links:LinkedIn: https://www.linkedin.com/in/tom-sanders-b372b1139/SLP Senior Living Photography: https://www.linkedin.com/in/tom-sanders-b372b1139/Senior Stock Photos: https://seniorstockphotos.com/

ProZD + Pals Episode 12: Thomas Sanders by ProZD

Een gesproken column van Thomas Sanders, advocaat/partner bij AKD en expert op het gebied van het toezicht en handhavingsrecht. Op 29 mei 2019 heeft de Afdeling bestuursrechtspraak van de Raad van State een belangrijke uitspraak gedaan over de werking van het vertrouwensbeginsel in het omgevingsrecht. We zijn nu ruim een jaar verder en Thomas neemt... Het bericht COLUMN 04: Het nieuwe vertrouwensbeginsel | de stand van zaken een jaar verder verscheen eerst op AboutLaw.

Big Q breaks down the latest Saints news of the day. Topics are Wednesday camp news, Saints interviews, Kamara has minor injury, WR's Thomas & Sanders get ready to return & more..Please subscribe, like & share the shows link!**********************************************************************❤️ GET THE MERCH NOW & SUPPORT THE PLATFORM WHO DAT BABY!❤️ FB SHOP: https://tinyurl.com/FBProshop❤️PRO SHOP 1 https://tinyurl.com/theproshops1❤️ PRO SHOP 2: https://tinyurl.com/theproshops2**********************************************************************

The Twenty-Fifth Episode of The Lady Lounge Sports Cast brings you high quality entertainment from high quality host! It's official the NC Dinos clinch the Korean Series! Now the waiting game begins! We're super excited to be apart of this historic team! The Host of The Lady Lounge Sports Cast are super excited for the start of the Korean Series! As always kick back, relax, grab a drink, and enjoy! Intro: (0:00-9:44) NC Dinos News: Dinos Clinch the Korean Series, Talk about the last three games against the Kia Tigers, LG Twins, and Hanwha Eagles, potentially buying another jersey for the Korean Series. (9:44-19:30) MLB Update: (19:30-22:20) Saints/NFL News: Saints defense is trash, Drew looked decent with the WR's he had, Thomas/Sanders out, give murray the ball more, 7,000 completions, Joey Syle Troll, Snow games are the best games, Bucs got AB, Falcons suck, Steelers Vs Titans, and Fantasy football segment! (22:20- 43:48) Pelicans/NBA News: Stan Van Gundy is our new Head Coach, JJ loves him, Trade Jrue, and Predictions for next year! (43:48-49:01) Thanks Guys!

Welcome to "Listener's Lowdowns," where I found listeners' cool theories and turned it into a series! In other words, I take a few listeners' "Sanders Sides" theory submissions and collab with them to create episode-long theory compilations. The debut episode of this series is all about the orange side, and who listeners Beastnorwi@ and Sama think he is. Thank you both again for your contributions and for inspiring me to create this new series! So, put on your cogitating cap and grab your favorite jar of jam, because it's time for some Lowdowns. ("Sanders Sides," "Sanders Asides," and their associated characters and episodes belong to Thomas Sanders and his team.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

Hi everyone! This is a short and sweet episode, in which I explain where I've been for these past few months and some future plans I have for this podcast. Also, if you haven't watched the newest Sanders Asides episode yet, I highly recommend it. ("Sanders Sides", "Sanders Asides", and their associated characters and episodes belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

Arcs, arcs, arcs. "Sanders Sides" is all about 'em, Logan and Roman need 'em, and I'm here to talk about 'em.  Specifically, this episode will cover my speculations on Logan's character arc and why I think it will center all around anger. Logan yelling, anger research, and a rather hopeful ending are in store. ("Sanders Sides" and its associated characters and episodes belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

In the finale of Side By Side, I'm talking psychology as I cover my thoughts about Roman in "Putting Others First." I connect Sigmund Freud's views on ego to what I think is causing Roman's defensiveness, strange behavior, and what I believe his future character development will be. Watch out for plenty of education and speculation! ("Sanders Sides" and its associated characters and episodes belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

VINE - Before They Were DEAD -- Before Vine would become one of the top apps for iOS and Android, launched the careers of King Bach, Thomas Sanders, Brittany Furlan, Nash Grier and Deez Nutz...Find out the story VINE before its untimely shutdown here.

THOMAS SANDERS Before They Were Famous -- Before Thomas Sanders took over Vine with his Stewie voice and Story Time Vines, he was a performance-obsessed chorus kid with an off-beat sense of humour, who was, ironically, also pretty shy. Find out all about his career and life prior to over 8 million fans on Vine, here.

In this episode we cover Thomas Sanders and his many charms(and friends). Enjoy this episode! Don't forget to follow us @watdkifun on tumblr,Instagram, and twitter.

Welcome to part three of Side By Side! In this episode, I go symbolism mining through "Putting Others First" as I cover what the meanings are of Lilypadton and the episode's introductory song, "Rhythm Redux." Be prepared for jokes and speculation galore. ("Sanders Sides" and its associated characters and episodes belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

Welcome to the second part of Side By Side! In this episode, I cover my thoughts about Logan and Janus and how Janus's impersonation of him (and their encounter during Logan's last lowdown) may not have been the only times the two interacted throughout the 51-minute episode. I also cover a theory about Virgil and why his name doesn't end with "u-s" when every other dark side's name thus far does. Prepare for speculations and theories galore, everyone! ("Sanders Sides" and its associated characters and episodes belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

There's a lot to cover for the new episode, huh? Well, that's exactly why I'm kicking off a multi-part podcast series (starting with this episode) called Side By Side where I cover all of my theories about the Sanders Sides episode "Putting Others First!" This episode shall be covering all that is Janus Sanders and if we should trust him or not. Stick around for education about persuasiveness and my thoughts about everyone's favorite snake boy! ("Sanders Sides" and its associated characters and episodes belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

Have you ever noticed how Logan sometimes bursts out with unexplained weirdness through Crofter's, Sherlock, and tantrums right before switching back into his serious, logical calculating mode? Well, in this episode of "Get My Good Side," I cover a new theory of mine concerning why he has these strange, quirky outbursts and how I think this will progress as the series continues. So be prepared for some psychological schooling and plenty of theorizing all about everyone's favorite nerdy brain cell! ("Sanders Sides" and its associated characters and episodes all belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

This episode of "Get My Good Side" is covering the various theories surrounding the newly released trailer for Selfishness VS Selflessness part two, including some coverage of my own theory as well. Let's all hope the next Sanders Sides isn't too angsty, or at least that we'll all have enough tissues and ice cream to cope with it if it is... ("Sanders Sides" and its characters and episodes all belong to Thomas Sanders.) --- Send in a voice message: https://podcasters.spotify.com/pod/show/getmygoodside/message

Yeah I have friends. But most of the time I feel like that Thomas Sanders video where one person gets left behind while going through a tight space. I’m here physically, not mentally.

Thomas Sanders joins me to talk about his current career on YouTube.

Remember that saying, smooth seas don't make a good sailor? Well, plug your nose and grab a lifejacket, because because this week's episode is a deep dive into the turbulent waters of heartbreak. Have no fear - Harto and special guest Thomas Sanders will guide you through a candid convo and onward to the sunny shores of healing and self-discovery! --- Support this podcast: https://anchor.fm/hannahlyze-this-with-hannah-hart--hannah-gelb/support

In deze aflevering van AboutLaw praten wij opnieuw met Thomas Sanders, advocaat en expert op het gebied van het toezicht en handhavingsrecht bij AKD N.V., over het vertrouwensbeginsel in het bestuursrecht. Op 29 mei 2019 heeft de Afdeling bestuursrechtspraak van de Raad van State een belangrijke uitspraak gedaan over de werking van het vertrouwensbeginsel in... Het bericht Afl. 19: Toezegging van een ambtenaar voor rekening van de overheid? verscheen eerst op AboutLaw.

In this episode, we are joined by the one and only Elizabeth Felsheim! In between laughs, we discuss vulnerability, community, and the way in which Lent has revealed our weakness to ourselves (spoiler alert: God is using it for good). Sountrack of the week:Greta Nisswandt, "The Ocean Shelf" - https://youtu.be/Oyhu1mJ0eNgIndigo Girls, "Love Will Come to You" - https://youtu.be/Jhypr1pUWyAThomas Sanders, "Birds" - https://youtu.be/ximNgj5mxMg

All the teams are converging and Luther and Billy can't let Ethan know! GUESTS: Johann Joseph and Nathan Renley

Dr Carolyn Lam:                Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr Greg Hundley:             And I'm Greg Hundley, Associate Editor of Circulation and Director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Well, Carolyn, our feature article is going to focus on trastuzumab-induced cardiac dysfunction in breast cancer patients. We will discuss with Stanford investigators their use of pluripotent stem cells that are differentiated to cardiomyocytes and subsequently exposed to toxins to determine an individual's susceptibility to cardio-toxicity from cancer treatment. But before we get to that, Carolyn, do you have a paper that you'd like to discuss? Dr Carolyn Lam:                Well, the first paper deals with cardiac biomarkers and asks the questions, can these biomarkers be useful for the diagnosis and risk stratification of syncope?" Now, this paper is from Dr Mueller and colleagues from University of Hospital Basel in Switzerland. They evaluated the diagnostic and prognostic accuracy of BNP, NT-proBNP, high-sensitivity cardiac troponin T, and high-sensitivity cardiac troponin I concentrations, alone and against the ones of clinical assessments in more than 1,500 patients presented with syncope to the emergency department in a prospective, diagnostic multi-center study. Now, cardiac syncope was adjudicated in 234 or 15% of patients. What they found was that the diagnostic accuracy from cardiac syncope, as quantified by the area under curve, was 0.77 to 0.78 for all four biomarkers. That was superior to that of the syncope-specific diagnostic score, EGSYS.                                                 Now, combining the four biomarkers further improved diagnostic accuracy to an area under curve of 0.81. Furthermore, using the four biomarkers at cutoffs achieved predefined thresholds for sensitivity and specificity and allowed rule-in or rule-out of 30% of all patients. Finally, the biomarkers predicted adverse cardiac outcomes with moderate to good prognostic accuracy and better than some of the existing syncope risk-prediction scores. Dr Greg Hundley:             Very interesting, Carolyn. Do you think we can now use this clinically? Should we be drawing these biomarkers on patients with syncope? Dr Carolyn Lam:                These results really do imply that these biomarkers look like useful tools for the early rule-out and/or rule-in of cardiac syncope in the emergency department. After all, these biomarkers are readily available, inexpensive, and results of this study suggest that they have potential to simplify diagnosis and to risk stratify in challenging presentations. However, before embracing the concept of ordering cardiac biomarkers routinely for syncope presentation, we really need to read the editorial by Dr Sandhu and Sheldon, in which important perspectives are presented, such as considerations of the certainty of the diagnosis of syncope, the usefulness of the comparative scores, the timing of testing, the potential unintended adverse consequences of testing. These editorialists concluded that, although promising, further work is needed to determine how the use of cardiac biomarkers should be incorporated into a risk-stratification algorithm. Dr Greg Hundley:             Wow, Carolyn. It sounds like we'd get a lot out of that particular editorial. I'm going to switch over and talk about NT-proBNP in patients with pulmonary hypertension. This is a paper from Dr Kelly Chin from UT Southwestern, and the study evaluated the utility of end terminal pro BNP level thresholds and assessing prognosis in pulmonary hypotension using the GRIPHON study. So GRIPHON is a global double blind, randomized placebo control event driven phase 3 study which assesses the safety and efficacy or a Prostacyclin agonist that promotes pulmonary arterial vasodilation.                                                 They performed the study in patients that were 18 to 75 years old with a diagnosis of idiopathic pulmonary hypertension, heritable hypertension or pulmonary hypertension associated with connective tissue disease, repaired congenital systemic pulmonary shunts, HIV infection, drug use or toxin exposure; and the diagnosis of pulmonary hypertension was confirmed by right heart catheterization and by a reduced 6-minute walk distance of 50 to 450 meters.                                                 Eligible patients were permitted to take their other therapies including Endothelin receptor agonists and phosphodiesterase type-5 inhibitors. The patients were categorized into low, medium and high in terminal BNP level subgroups according to two thresholds. First, by just the tertiles within the study overall and the secondly by the ESC guideline cutoff ranges. Dr Carolyn Lam:                Nice, so what did they find Greg? Dr Greg Hundley:             Well first of all both thresholds either the tertile one of the ESC in follow-up NT-proBNP categories were highly prognostic for future morbidity and mortality. And their time dependent analysis the risk of experience a morbidity or mortality even was 92% and 83% lower in the treated patients with a low and medium NT Pro BNP level. And 90% and 56% lower in placebo treated patients with low and medium NT-proBNP levels. So both, whether you're taking that drug of not, the NT-proBNP levels were prognostically valuable. More pronounced treatment benefit of selexipag was seen in the medium and low proBNP groups. There was a positive value for the interaction term. Dr Carolyn Lam:                Wow, sounds like two really important findings. Dr Greg Hundley:             Yes, exactly Carolyn. So first, NT-proBNP levels are highly prognostic for pulmonary arterial hypertension progression. And having NT-proBNP in the low range, by improving to or maintaining low NT-proBNP levels is a clinically relevant treatment goal for those with pulmonary artery hypertension. And of course as we described this was a very diverse well represented group of many different types of patients with pulmonary hypertension. Then second, while selexipag the study drug was beneficial in all NT-proBNP categories, the treatment effect was greater in those with low and medium categories versus the very high. Suggesting that earlier selexipag treatment may be of greater benefit. But very interesting biomarker study that follows up on yours Carolyn. Dr Carolyn Lam:                Indeed! Dr Greg Hundley:             Carolyn what about your next paper? Dr Carolyn Lam:                Well I want to switch tracks now and talk about iron. And the question is, how does intravenous iron repletion augment exercise capacity in chronic heart failure? Even if hemoglobin doesn't change. So, first some background right, now, besides hemoglobin it's important to recognize that iron is an obligate component of the mitochondrial enzymes that generate cellular energy in the form of adenosine triphosphate and phosphocreatine. So dynamic phosphorous magnetic resonance spectroscopy is a noninvasive tool that can really quantify the in vivo muscle energetics by measuring the kinetics of phosphocreatine recovery after exertion. These authors use this technique, and these are Dr Okonko from King's College, London British Heart Foundation sender of excellence, school of cardiovascular medicine and sciences. The James Black Center in London and colleagues. And what they did was they tested the hypothesis that intravenous iron repletion in chronic heart failure would enhance skeletal muscle energetics as reflected by a shorter phosphocreatine recovery halftime on phosphorous magnetic resonance spectroscopy imagining of the skeletal muscles. And they looked at 40 patients with chronic heart failure with reduced deduction and iron deficiency in a randomized double blind placebo controlled ferric iron and heart failure trial. Dr Greg Hundley:             So, what did they find? Dr Carolyn Lam:                They found that a single total dose infusion of intravenous iron repleted iron stores and augmented skeletal muscle energetics at 2 weeks post infusion. Enhancements in the skeletal muscle energetics which implied better mitochondrial function were accompanies by improved symptoms despite no change in hemoglobin at 2 weeks. So, this trial really provides mechanistic support for iron repletion in patients with chronic heart failure and its very importantly discussed in an editorial by Peter van der Meer, Haye van der Wal, and Vojtech Melenovsky. And I really suggest that everybody read that. Dr Greg Hundley:             Well, I'm going to talk a little bit about dietary omega-6 fatty acids and the incidence of cardiovascular disease and mortality. And this paper is from Matti Marklund from the Georgia Institute for Global Health and the University of New South Wales in Sydney, Australia. The study focuses on linoleic acid which is an omega-6 polyunsaturated fatty acid that we get from pumpkin seeds, flax seeds, walnuts, soybean oil, canola oil and grapeseed. It's been associated with a decrease in cardiovascular risk, but others have worried about an effect of consumption mainly the downstream production of arachidonic acid which can give rise to eicosanoids that are both pro inflammatory and pro thrombotic.                                                 And it's interesting Carolyn, several organizations suggest replacing saturated fat and carbohydrates with linoleic acid. So this study was really performed to address whether consumption of linoleic acid is associated with future cardiovascular events. In the study, investigators measured linoleic acid as well as arachidonic acid levels and from a global consortium across 30 perspective observational studies from 13 countries they performed multi variable adjusted associations of circulating an adipose tissue linoleic and arachidonic acid biomarkers with incident total cardiovascular disease and subtypes of cardiovascular disease including, coronary heart disease, ischemic stroke and cardiovascular mortality and this was all done as pre-specified analytic plan. Dr Carolyn Lam:                Wow, so what did they find? Dr Greg Hundley:             Well did I put you to sleep discussing all of that? Dr Carolyn Lam:                No! You have to tell me what they found. I'm seriously so interested in this topic because being vegetarian I actually get my source of omega fatty acids exactly from these sources. Dr Greg Hundley:             Okay, so Carolyn, higher levels of linoleic acid were associated with lower risk of total cardiovascular disease, ischemic stroke, cardiovascular mortality. While arachidonic acid was not associated with cardiovascular risks. And so, the clinical implications of the results support the potential benefits of main dietary omega- 6 fatty acid. That is linoleic acid for cardiovascular disease prevention. Now, while the trial is not randomized so we don't have definitive answers, the results do not support any theorized cardiovascular harms of consuming omega-6 fatty acids. And there is an excellent review on polyunsaturated versus saturated fat intake by Thomas Sanders from King's College, London as an editorial to this piece. So Carolyn I think we're safe right now in consuming linoleic acid. So how about a transition to our featured article and learn a little bit more about trastuzumab-induced cardiac dysfunction. Dr Carolyn Lam:                Absolutely! Dr Greg Hundley:             Great.                                                 Welcome everybody, we have a fantastic paper to discuss. We're going to review human induced pluripotent stem cell derived cardiomyocytes and how they can be used to identify individuals at risk of trastuzumab-induced cardiac dysfunction after treatment for breast cancer. We have today Nazish Sayed and also Dr Joseph Wu, both from Stanford University in California.                                                 Welcome gentlemen. Dr Joseph Wu:                   Thank you for inviting us. Dr Nazish Sayed:              Thank you. Dr Greg Hundley:             Nazish tell us a little bit about what are these human induced pluripotent stem cells and then also describe your experiment and what were your results? Dr Nazish Sayed:              So, induced pluripotent stem cells is about 10 years ago I knew technology where you can actually turn back the clock by you taking human fiber blast or blood cells and then you can test full reprogramming factors and turn back differentiated cells to pluripotent stem cells will mimic like catalytic stem cells. The catalytics include self-renewal, pluripotency and the most important that they can be differentiated to any cell type in the body. For example, cardiomyocytes or endothelial cells the neuron and kind of mimic these differentiated cells from the same individual from where the IPSCs were derived from.                                                 So, what we did in our study is we used this platform to derive these pluripotent stem cells from patients and then differentiated them into a cardiomyocyte to understand what would these human cardiomyocytes behave in a dish when treated with a Herceptin or trastuzumab and then kind of determine the underlying mechanism for this cardiac dysfunction. It seemed really difficult to model trastuzumab and use cardiac dysfunction as a heart which is the receptor for the trastuzumab is expressed only in humans.                                                 People have usually relied on animal model and for the first time what we did is we used these ideas of cardiomyocytes to model this dysfunction in a dish. Our results were pretty straightforward. We found that the IPSCs cardiomyocytes when treated with the chemotherapy agent showed cardiac dysfunction in the case of decrease contractility. The contraction velocity of these each individual cardiomyocytes is significantly reduced. More with this was also confirmed by having impaired calcium cycling which is very important for the contractility of these cardiomyocytes.                                                 But I think the most important thing which we determined from the study is that individuals who are treated with trastuzumab have a metabolic impairment in these cardiomyocytes which is convenient but however have a severe impact on this contractility and calcium handling in these cardiomyocytes. And that was one of the gist of these papers to figure out the metabolic impairment could be a target where we can improve this cardiac dysfunction in these patients. Dr Greg Hundley:             And so, after you discovered this, I noticed you also did some work with AMPK activators and perhaps would reverse some of the dysfunction. Could you describe a little bit what are AMPK activators and then how did they reverse the dysfunction that you observed? Dr Nazish Sayed:              In our study we characterized these IPS cardiomyocytes from these individuals and then we ran a whole sequencing of them after treatment where trastuzumab to see which of the pathways which could be down regulated or dysfunction when compared to the control patients which are not treated with trastuzumab. And one of the most significant pathways which we found was in PK pathways which was down regulated in the trastuzumab treated IPSC cardiomyocytes. So knowing that the AMPK activators are used for metabolic diseases, for example being diabetes and metabolic dysfunction, we thought that this same thing could be used in a dish where we can take these AMPK activators and simultaneously cotreat cardiomyocytes with Herceptin or trastuzumab to see if we can rescue the phenotype and indeed you can see in our paper we used 4 different AMPK activators with metformin which is a commonly used diabetic drug. Showing the best rescue for that trastuzumab induced cardiac dysfunction. Dr Greg Hundley:             Very intriguing because it looks like you've been able to harvest cells from individuals and then pre-treat them, understand the mechanism of dysfunction, understand who's at risk of dysfunction and then offer therapeutic interventions to perhaps prevent that dysfunction in this patient population. Joe, turning to you now, this is really revolutionary technology it seems to me. Can you describe how long does this process take? Is this something that we see might come into clinical medicine soon? Dr Joseph Wu:                   We're really excited about this technology that Nazish has described. I think as you know we've been working on this platform for the past 10+ years. In terms of the timeline, right now it takes us about a month to generate the induced pluripotent stem cells. It takes us another month to expand, propagate the IP itself. It takes us another month to generate the IPS cardiomyocytes. And it will take us probably another month to do all the phenotypic characterization in terms of using these IPS cardiomyocytes to expose them to various chemotherapy drugs and see how the chemotherapy drugs have an effect on these cardiomyocytes.                                                 So, I would say the total timeline is 12 months at this moment. Is it possible that the timeline could be crunched, could be shrunk over time? Yes that's possible, I think the technology is improving month by month, week by week because there are many different labs trying to work on this platform trying to improve the whole process. But right now one of the limitations that as you pointed out is this 4 month time period. And also the cost that's associated with this. But we're hopeful that over time that both the time, the costs can go down so that we can offer this type of platform to help patients diagnosed with cancer, find out what kind of chemotherapy is safe to use, what kind of chemotherapy is not safe to use. Dr Greg Hundley:             So, we're working towards clinical applications but at this point in time it looks like a fantastic platform for understanding, diagnoses and understanding pathways that for patients particularly as they are treated for cancer will experience cardiovascular dysfunction. So, switching a little bit and asking a related question. Patients that receive trastuzumab often also receive doxorubicin. Especially the breast cancer patients. If you looked at this technology trying to understand, and certainly those more at risk for trastuzumab associated left ventricular dysfunction, are the patients that previously received doxorubicin. Have you and your group looked at patients that have also received doxorubicin and then went on to receive trastuzumab relative to those that received trastuzumab alone? Dr Joseph Wu:                   I think for these two populations for this particular study, we tried to keep them clean. Meaning that we're looking mostly for trastuzumab treated patients, otherwise it's hard for us to piece out whether the toxicity was due to one medication or the other medication. But what you are asking is very important because as you pointed out many of these patients received both and I think for future studies we should be able to model both medications, meaning that take some IPS cardiomyocytes treated with doxorubicin, treated with Herceptin by itself and treated with both the medications.                                                 In previous studies we have studied using IPS cardiomyocytes the effects of doxorubicin induced cardiac toxicity. In just the assessment, doxorubicin is a very common effective chemotherapy for breast cancer medications and just like Herceptin, the clinicians struggled with the issue, as we cannot predict which patient will develop toxicity. And then granted the doxorubicin induced toxicity has a slight different mechanism compared to perception induced mild cardiac dysfunction that this Nazish had mentioned about. But these are kind of the studies that we're very excited because now for the first time we have a way to model this. Otherwise they alternative would be not possible, for example it would not be possible for us to biopsy breast cancer patients woman's heart to study the cells.                                                 Especially in the case of perception. The receptor that's being studied is not present in animal model cells. For example not present in mouse cardiomyocytes and therefore it would be very difficult to understand the mechanism and this is the reason why the patient specific and disease specific IPS cardiomyocytes become so useful. Dr Greg Hundley:             Do you find another emerging therapy in this entire realm is the immunotherapies? Do you think this technology will be applied to determine susceptibility to immune mediated toxicity? Dr Joseph Wu:                   This is a very good question as well Greg. We've been thinking about studying that and as you know, it's a more complicated system because it involves patients’ immune response, the myocardial, to inflammatory infiltrates that happens. So we have a couple projects going on. One is to study direct effect of the immunotherapy on the cardiomyocytes and then the second angle is to take patients who are in full myocarditis and collect their patients urine samples, blood samples and to see if we could expose these IPS cardiomyocytes to the patients urine samples to see what is the effect. For these IPS cardiomyocytes for future studies we're also trying to make it more complicated by generating not just the cardiomyocytes by itself, but generating what we call engineered heart tissues. In which it's a chunk of human heart muscles that would have the patients cardiomyocytes, patients fibroblast, patients endothelial cells and expose them to the patients serum.                                                 But that kind of study would take much longer period of time because the number of people who have these types of immunotherapy induced myocarditis it's relatively low compared to patients who have Herceptin or doxorubicin induced cardio toxicity. This is also part of the reason why we're very much interested in collaborating with big centers throughout the country like York Center to see if we could understand this process better as a team. Dr Greg Hundley:             Excellent. I want to thank both of you for this really elegant discussion and perfect work moving forward. In summary, you've illustrated an ability to withdraw human pluripotent stem cells, differentiate them to cardiomyocytes and then perform tests on them to forecast susceptibility to various treatments used commonly for women with breast cancer. And in this study identifying mechanisms for trastuzumab toxicity. And then perhaps therapeutic interventions using again human cells which has a marked leap as you've identified over doing mouse studies, particularly for studying trastuzumab when the receptors the HER2 receptors in mirroring models differ substantially to those in human subjects. Dr Joseph Wu:                   Thank you Greg. And we want to also express our thanks to our collaborators, our colleagues who contributed to the study and most importantly to the patients who helped us with these studies. Dr Greg Hundley:             I want to thank both Nazish and Dr Wu from Stanford and Carolyn and I wish you the best for the coming week and we look forward to speaking with you again next week. Dr Carolyn Lam:                This program is copyright American Heart Association 2019.  

There is a lot of talk about the transferable skills athletes develop while playing sports. Society praises the work ethic, teamwork, and perseverance it takes to compete at the highest levels in sports. However, the talk is often nothing more than general platitudes lacking specificity on how these transferable skills play out in the real world. In this episode, former Atlantic Sun Player of the Year, Thomas Sanders, takes us step by step through the ups and downs of his pro basketball career. He shares how his experiences as an athlete prepared him to start and grow a thriving Photo Booth company that is currently worth over one million dollars. He shares how pro basketball shaped his perspective and prepared him for life after sports.   Show Notes ► Web: https://blog.parallelplatform.com/ep3-pro-basketball-to-business-owner-thomas-sanders/   Connect with Parallel ► Instagram: https://www.instagram.com/parallelpla ► Twitter: https://twitter.com/parallelco   Connect with Tyler ► Twitter: https://twitter.com/tylerwbaker  

DATUM OPNAME: 22 maart 2019. In deze aflevering van AboutLaw praten wij met Thomas Sanders, advocaat en expert op het gebied van het toezicht en handhavingsrecht bij AKD N.V., over de formele rechtskracht en met name over drie recente uitspraken van Afdeling bestuursrechtspraak van de Raad van State over dit onderwerp. Wat is formele rechtskracht... Het bericht Afl. 10: Formele Rechtskracht verscheen eerst op AboutLaw.

In this episode the lovely Maddie Barnes and I discuss Non-binary representation, queer Youtubers, Ash Hardell, Thomas Sanders, Stevonnie and Captain America and manage to only gush over each other a little at the beginning!

Birds a song written by Thomas Sanders and performed by Roman Reyes, my son! • Birds performed at the Coffee House by Roman & Shayna • Rhiannon cover with Roman and Friends • Roman singing Humble and Kind cover --- Support this podcast: https://anchor.fm/melissa-reyes/support

October is National Sarcasm Awareness Month. Jack and I read sarcastic comments left by fans. Then, Thomas Sanders joins and teaches us how to make misleading compliments. We also pitch the worst videos of all times. See our tweets and costumes here: https://goo.gl/zPTLrf -Thanks to our sponsor great sponsor NatureBox and Shopkick for helping keep this podcast free! - Want to see us and not just hear us? Go to Fullscreen.com/nottoodeep right now! Get a week for free!

If you're a Steven Universe fan, and your dream is to someday work on the show, then this episode is for you! Storyboard Revisionist Maya Petersen and Storyboard Artist Amber Cragg share their incredible stories about how fan art and fandom led them to joining the crewniverse! Cartoon Network Games Creative Director Mario Piedra, and Chris Graham who designed the mobile game, "Attack The Light," and upcoming console game "Save The Light," also turned their love of Steven Universe into jobs! And Youtube Star and superfan Thomas Sanders reveals how he discovered the show and started working with the cast.

Today's Theme: Art –Why is there so much bad poetry? –Does writer's block even exist? –The art of social media * * * iTunes: https://itunes.apple.com/us/podcast/can-you-not/id1052603232 Soundcloud: https://soundcloud.com/cynpodcast YouTube: https://www.youtube.com/channel/UCramT-247L0Salwksa1ULng Facebook: https://www.facebook.com/CanYouNotPodcast/ Twitter: https://twitter.com/CYNPlz

Today we speak to Terry Saunders one-third of the For Formula one's sake podcast about the new F1 season and why the sport that we love is so boring Miraa May’s haunting vocals soar on I Don't Want Ya (Didi), a piece of music that beautifully mixes Dance Hall, Bhangra and street soul. Mainline is a track by English indie combo Teleman. The group consists of Thomas Sanders (vocals, guitar), Jonny Sanders (synths), Pete Cattermoul (bass) and Hiro Amamiya (drums). Handsworth Revolution is the title track of the third album by British reggae outfit Steel Pulse. Named after the Handsworth district of Birmingham, the band's home district to which the album was dedicated. This track we nominated by Michael Goldwasser. "(We Don't Need This) Fascist Groove Thang" is a song performed by British synthpop band Heaven 17. With a stance against racism and fascism, it was a minor hit in the UK in 1981, despite being banned by the BBC. Was nominated by See acast.com/privacy for privacy and opt-out information.

Vine was a creative and quirky little social network founded on six-second looping videos. So why did Twitter decided to shut it down? In this episode, we breakdown why Twitter is shuttering video-looping network Vine and put Hype - the new app from Vine's original creators, to the test. What;s more, Hype (and former Vine) creator Rus Yusupov tunes in to our Hype livestream and answers a couple of questions from the team. The Demise of Vine Important News about Vine - http://bit.ly/2fL7p5I Twitter shutting down Vine - Vine on Medium - http://tcrn.ch/2fjCyxV Why Vine Died - The Verge - TechCrunch - http://bit.ly/2eV6X2W Twitter Might Still Save Vine - Tech Crunch- http://tcrn.ch/2egihsU All About Hype Rus Yusupov tweet’s "Don't sell your company" - http://bit.ly/2g9PNO2 Hype website -https://www.hy.pe/ Hype app blends live video into a rich multimedia mix - TechCrunch - http://tcrn.ch/2fwcfEW MSD Roundup, 11/11/16 Video: The Mindset Digital podcast team checks out Hype: https://vimeo.com/192494389 Some of our favorite Vines: Anything by Thomas Sanders - http://bit.ly/2fkAEvR BatDad - http://bit.ly/1s3pyg0 Logan Paul - http://bit.ly/2fkAEvR Stop Motion art by Yves Das -https://vine.co/Yves.Das Back in 2013, BuzzFeed picked their favorite stop-motion Vines. - http://bzfd.it/2geTJOy And of course, there was that time we threw a red solo cup around the office. - http://bit.ly/2eZkOIv

Dennis Cooper's dead blogger blog, Twitter Verification, Thomas Sanders, Do Not Track, Periscope, Hannah Hart, YouTubers on TV, Birkenstock, Ugly Instagram, Rihanna and Pornhub. . .all these social media headlines.

[jwplayer mediaid=”14193″]Download Podcast Tonight on New Abolitionists Radio we are joined by former prison guard and military veteran Thomas Sanders. Two weeks ago Thomas briefly…