Podcasts about rabel

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Best podcasts about rabel

Latest podcast episodes about rabel

Sound Interrogations
Sound of Ladies Night

Sound Interrogations

Play Episode Listen Later Mar 24, 2025 104:31


Send us a textIt's Women's History Month, so we celebrate with songs from the Ladies over the years.  We also invited a special guest, Cousin Nicki, to join Rabel, Special K, and S Mulvay for the discussion.  Join us to find out who Special K considers the "Scorpions of Female Rock", who is considered the "Ivory Queen of Soul" and whether or not Rabel likes any of the songs/artists.  

Vietnam Veteran News with Mack Payne
Episode 2977 – Tribute to Vietnam MoH recipient U.S. Army SSG Laszlo Rabel – A Saint.

Vietnam Veteran News with Mack Payne

Play Episode Listen Later Feb 15, 2025 15:57


Episode 2977 of the Vietnam Veteran News Podcast will feature Medal of Honor recipient U.S. Army SSG Laszlo Rabel. Information featured in this episode comes from Wikipedia and the Minnesota Medal of Honor Memorial.. U.S. Army Staff Sergeant Laszlo Rabel … Continue reading →

Sound Interrogations
Sound of Litmas

Sound Interrogations

Play Episode Listen Later Dec 13, 2024 76:32


Send us a textYou ready for our first Litmas episode?  Rabel and Special K give SMulvay a ton of grief for not including some classic artists.  SMulvay hits The Fam with songs that they would have never heard otherwise and the Team talks about the darker side of Santa...   Merry Litmas and Happy New Year!  

Kentucky Fried Homicide
The Trick or Treat Murder of Peter Fabiano.

Kentucky Fried Homicide

Play Episode Listen Later Oct 23, 2024 44:43


Send Kris and Rob a Text Message!The Chilling Halloween Night Murder of Peter FabianoHalloween night is supposed to be a time for tricks, treats, and innocent fun. But on October 31, 1957, one seemingly routine knock on the door in Los Angeles turned into a real-life nightmare. Peter Fabiano, a husband, father, and owner of a successful beauty salon, opened his door that evening, unaware that what awaited him wasn't a typical trick-or-treater, but cold-blooded murder.The Night of the CrimeIt was just past 11 PM when Fabiano's wife, Betty, heard the knock at their door. Peter answered, expecting late-night trick-or-treaters. Instead, a figure stood at the door dressed in a mask, aiming a paper bag toward him. Without warning, a shot rang out. Peter collapsed, and his life was over in an instant. The shooter fled into the night, leaving behind a shocked neighborhood and a grieving wife.A Case of Jealousy and DeceptionIt wasn't long before investigators began to uncover a tangled web of secrets, betrayal, and forbidden love. Betty Fabiano revealed to police that her husband had a falling out with a woman named Joan Rabel, a photographer with a peculiar interest in their marriage.As detectives dug deeper, they discovered that Rabel harbored romantic feelings for Betty and was intensely jealous of Peter's role in her life. Rabel recruited her friend, a troubled woman named Goldeen Pizer, to carry out the murder. Pizer, captivated by Rabel's manipulation, agreed to pull the trigger. On that fateful night, Pizer donned the disguise of a trick-or-treater and shot Peter Fabiano at point-blank range.Justice for Peter FabianoThe case shocked Los Angeles, not only for the brutal nature of the crime but also for the motive behind it—a twisted love triangle culminating in murder. Both Rabel and Pizer were eventually caught and confessed to their roles in the killing. In 1958, they were convicted of second-degree murder, with both women sentenced to prison.To this day, Peter Fabiano's murder serves as a reminder of how jealousy, manipulation, and obsession can spiral into unimaginable violence.If you're fascinated by true crime stories like this, be sure to listen to our latest episode of Hitched 2 Homicide, where we delve even deeper into the plans of Joan Rabel to win back the affections of Betty Fabiano.Sources used for this podcastSupport the showJOIN THE HITCHED 2 HOMICIDE IN-LAWS AND OUTLAWSSTART KRIS CALVERT'S BOOKS TODAY FOR FREEH2H WEBSITEH2H on TWITTERH2H on INSTA

Guitar Karabiner - Heavy Metal e Cultura Pop
#225 AHSOKA (Temp 1) - É Rabels ou Ahsoka ??? Não consegue né Moises!

Guitar Karabiner - Heavy Metal e Cultura Pop

Play Episode Listen Later Oct 23, 2023 28:48


Hoje temos nossas opiniões da nova temporada de Rabel... Ahsoka #GuitarKarabiner #Ahsoka Quer enviar um email para ser lido no próximo podcast? envie para guitarkarabinerbr@gmail.com

HORECA AUDIO NEWS - Le pillole quotidiane
7043 - Inizia il conto alla rovescia per Bolle di Malto, la rassegna nazionale dei birrifici artigianali

HORECA AUDIO NEWS - Le pillole quotidiane

Play Episode Listen Later Aug 3, 2023 11:02


Dopo il successo dell'anno scorso con più di 100 mila presenze, provenienti da tutta Italia e dall'estero, 45.000 litri di birra erogati, 80.000 bicchieri spillati, 30 relatori per gli Stati Generali della Birra, 40 ore di musica dal vivo e 5 lingue straniere parlate (inglese, tedesco, spagnolo, francese e olandese), ritorna il sapore di BOLLE DI MALTO, la Rassegna Nazionale dei Birrifici Artigianali che per la sua VII Edizione si terrà dal 28 agosto al 4 settembre 2023 a Biella. Centinaia di birre artigianali provenienti da tutto il territorio nazionale, street food di qualità, musica dal vivo con artisti locali, esordienti, nazionali e incontri con esperti e laboratori del gusto dove sperimentare la gastronomia locale e nazionale. Per otto giorni la il capoluogo biellese diventa la Capitale italiana della Birra Artigianale con 8000 mq di esposizione, birrifici artigianali da 20 regioni italiane, oltre 300 stili di birra, più di 100 varietà di cucine di strada e 2400 minuti di musica live.I punti di forza di Bolle di Malto sono legati principalmente alla ricca offerta e alla tipicità dei birrifici artigianali che quest'anno rappresentano un campione significativo per quanto riguarda l'attuale panorama brassicolo italiano con nomi come: Almond '22, Altavia, Basei, Beer In, Birra Perugia, Birrificio Courmayeur, Birrificio degli Ostuni, Birrificio del Vulture, Canediguerra, Croce di Malto, Elvo, Hilltop, Il Mastio, Jeb, Kauss, La Villana, Okorei, Otus, Piccolo Birrificio Clandestino, Rabel, Retorto, Un Terzo ed un muro di spine realizzato per accogliere le altre regioni ospiti.

Lessons From The Front
Rabel McNutt: Starting A Non-Profit At Age 10, Lessons From The Front #066

Lessons From The Front

Play Episode Listen Later Feb 21, 2023 24:30


When Rabel McNutt was seven years old, she attended the funeral for her Godfather, Walter D. Ehlers, who was awarded the Medal of Honor for his bravery in Normandy in June 1944 following D Day. From this, a spark of service was born: How can we honor the last Medal of Honor recipient from World War II with a state funeral? A few years later, Rabel managed to do just that with the passing of 1945 Medal of Honor recipient Hershel "Woody" Williams. On this edition of Lessons From The Front, hear how even the smallest of servants can make a big difference. These are Rabel's Lessons From The Front.Carry The Flag is a free education-based program that teachers and youth leaders can use to connect with the next generation about the meaning of the flag, the different patriotic holidays, and the sacrifices made by our military, veterans, first responders and their families. Learn more about how you can get involved at https://www.carrytheload.org/carry-the-flag/

Tarataña
Tarataña - De la reaparición de Kepa al Babieca Folk - 30/10/22

Tarataña

Play Episode Listen Later Oct 30, 2022 60:07


Por fin Kepa Junkera volvió a dejarse ver en público casi cuatro años después de sufrir un ictus del que todavía se está recuperando. La noticia nos llenó de alegría y arrancamos con él la Tarataña dominical para enlazar con el Babieca Folk, que se celebra la segunda quincena de noviembre en Burgos. Y, por supuesto, contamos otras más actuaciones, novedades, y el anuncio para colaborar en el mecenazgo del disco con el que Lévid quiere celebrar sus diez años como grupo de folk. Este repertorio da una idea: 1.- Kepa Junkera, “Del Hierro a Madagascar” (con Pedro Guerra) 4:51 2.- Kepa Junkera, “Agarrao do Vilar de Cabeiras” (con Xabier Díaz & Adufeiras de Salitre) 2:31 3.- Cadavieco y Bárcena, “Rabelá” 2:41 4.- Xosé Liz, “Jota portuguesa y Jota del Guijarr” 5:19 5.- Lévid, “Qé pena que no fuera más alto” 3:16 6.- Azarbe, “Mañanicas floridas” 3:59 7.- Tría, “Es blat i sa calor” 3:38 8.- Vallarna, “Balas y fuego” 4:59 9.- Vallarna, La zarzamora” (con Jesús Cifuentes) 5:00 10.- Pez Mago, “Juana de Arco” (con Fetén Fetén) 5:40 11.- Ángel Petisme, “Azurro” 3:40 Escuchar audio

RTL Matin
Guillaume Rabel-Suquet, du groupe Arc, est l'invité de RTL Midi

RTL Matin

Play Episode Listen Later Sep 2, 2022 5:22


Ecoutez Les invités de RTL avec Pascal Praud et Céline Landreau du 02 septembre 2022

L'invité de RTL
Guillaume Rabel-Suquet, du groupe Arc, est l'invité de RTL Midi

L'invité de RTL

Play Episode Listen Later Sep 2, 2022 5:22


Ecoutez Les invités de RTL avec Pascal Praud et Céline Landreau du 02 septembre 2022

En Cristo
Domingo XVII del T.O. Sta Cristina de Bolsena. San Chárabel Makhlouf

En Cristo

Play Episode Listen Later Jul 24, 2022 14:14


24 DE JULIO - DOMINGO XVII DEL T.O. STA CRISTINA DE BOLSENA. SAN CHÁRABEL MAKHLOUF

Personalized Medicine Podcast
Ep#044: Applying Nanoparticles and Microfluidics to Personalized Medicine with Martin Rabel

Personalized Medicine Podcast

Play Episode Listen Later Jun 29, 2022 48:59


Welcome to the next episode of the Personalized Medicine Podcast. In this episode, our host Aradhana talked to Martin Rabel, the Field Application Scientist at Precision Nanosystems, about nanoparticles, microfluidics, gene delivery in the context of personalized medicine.Tune in to this episode to learn more about: ◦ Precision Nanosystems and their mission ◦ Role of nanoparticles and microfluidics in Personalized Medicine ◦ Next-Gen microfluidics technologies ◦ Application of nanoparticles in pharmaceutical applications ◦ Challenges in developing RNA-based lipid nanoparticles ◦ Role of regulatory bodies in implementation of personalized medicine approaches ◦ The outlook on the future of personalized medicineGet in touch with Martin: ◦ LinkedIn: Martin Rabel ◦ Twitter: @rabel_martin

Rozmowy bez asekuracji
Odc. 188 – Skuteczny marketing według CUK Ubezpieczenia – Marcin Dyliński i Paula Rabel (CUK Ubezpieczenia)

Rozmowy bez asekuracji

Play Episode Listen Later Jun 14, 2022 29:59


Indie Game International
75: Kate Rabel | Sugarpunch Games | Behind The Beyond

Indie Game International

Play Episode Listen Later Jun 9, 2022 81:48


Kate Rabel is the owner of Sugarpunch Games, developer of the upcoming point-and-click-adventure game Behind The Beyond. There is currently a demo of the game available on Steam. Behind The Beyond is based on Hungarian folklore and I really enjoyed the story, atmosphere, and unique PAC UI used in the game's demo. I highly recommend it! Kate was called out by past guest Tom Hardwidge, developer of Lucy Dreaming. In this episode we will dicuss introducing RPG elements into a point-and-click game, game jams, being a solo dev, dealing with crunch, the struggles of Kickstarter, and much, much more. Behind The Beyond on Steam: https://store.steampowered.com/app/1148310/Behind_the_Beyond/ Behind The Beyond on the web: https://behindthebeyond.com Behind The Beyond on Twitter: @BehindTheBeyond Sugarpunch Games on Twitter: @SugarpunchGames Sugarpunch Games on the web: https://sugarpunchgames.com Follow IGI on Twitter: @IndieGameINTL Consider supporting the IGI mission by becomiong a Patron: https://www.patreon.com/indiegameINTL

Player B Golf Podcast
Bill Rabel - Penn Ohio Golf Trail

Player B Golf Podcast

Play Episode Play 31 sec Highlight Listen Later Jan 20, 2022 58:25


On this episode, Bill Rabel from the Penn Ohio Golf Trail join us again to catch up.We recap the 2021 golf season and chat about new course played on the Penn Ohio Golf Trail. We talk about some of the amazing photos and content that has helped Penn Ohio Golf Trail show off their courses and update their website.Bill answers our 'At The Turn' questions and he talks to us about how to plan a golf trip.  He talks us through the process he uses to help each individual build their package and what to consider when you are planning a trip for your group. Be sure to check out the Penn Ohio Golf Trail on Instagram at @PennOhioGolfTrail and at: https://www.pennohiogolftrail.com/ Don't forget to hit subscribe so you don't miss an episode and leave us a comment/review.  Follow us on Instagram at @PlayerBPodcast, @Club_Twirl_ Ohio and @PunchOutGolf

The Blabbering Blokes Podcast
Invaded : Kulith Rabel

The Blabbering Blokes Podcast

Play Episode Listen Later Dec 18, 2021 58:09


We once again catch up with one of our high school mates, Kulith. Kulith is no stranger to change and therefore we hear his opinions on transitioning from a different country, to a different city, to transitioning from uni to work life. We also delve into a peak of what it was like representing the UAE under 19 Men's cricket team.As always, we hope you enjoy this episode! Make sure to follow us on Spotify and subscribe to us on Apple and Google podcasts and please let us know what you think on our Instagram (@blabberingblokespod).See you next week! Żegnaj!

Bloody Podcast
Ep. 132: The Trick Or Treat Murder (Goldyne Pizer & Joan Rabel)

Bloody Podcast

Play Episode Listen Later Oct 31, 2021 48:26


Peter Fabiano thought he was opening the door to some trick or treaters when he met his fate on Halloween Night 1957. Maria brings us the story of the Trick or Treat murder, and we somehow make 1950's stereotypes worse. @BloodyPodcast on all social media. www.patreon.com/bloodypodcast PLEASE SUBSCRIBE, RATE & REVIEW!

On dira ce qu'on voudra
Représentation et diversité en art

On dira ce qu'on voudra

Play Episode Listen Later May 10, 2021 29:15


Discussion sur la faible représentation des personnes asiatiques à l’écran avec Khoa Lê; Peaux blanches, masques noirs avec Estelle Djandjo; Julie Dufort et Naïla Rabel se prononcent sur Ziwe, la nouvelle émission de Ziwe Fumudoh.

diversit repr ziwe ziwe fumudoh rabel julie dufort
Faits Divers
Naïla Rabel - Faits Divers #12

Faits Divers

Play Episode Listen Later Apr 7, 2021 60:31


Salut!!! Dans cet episode, J'ai une très bonne discussion avec la comedienne et influenceuse Naïla Rabel. Merci d'écouter de partager et j'espère que tu vas passer une belle journée! Pour plus de Faits Divers en exclusivité: https://www.patreon.com/mairedelaval

The Individualist
#8: Ranking the Presidents with Jared Rabel

The Individualist

Play Episode Listen Later Mar 7, 2021 114:50


Jared Rabel is back once again so we can actually discuss what I'd originally intended to the first time he was on, his tier list of the US presidents. Find Jared on Twitter @JradRabel His work at libertytalks.net

The Individualist
#7: Jared Rabel returns

The Individualist

Play Episode Listen Later Feb 28, 2021 87:08


Jared Rabel, my guest from the previous episode, returns to discuss his rankings of various political ideologies. Find Jared on Twitter @JradRabel His work at libertytalks.net

rabel
Player B Golf Podcast
Episode 5: Bill Rabel - Penn Ohio Golf Trail

Player B Golf Podcast

Play Episode Play 31 sec Highlight Listen Later Feb 26, 2021 66:16


We kick off episode 5 recapping Tiger's accident and Max Homa winning at Riviera.Bill Rabel from the Penn Ohio Golf Trail joins us on this episode. Bill talks to us about what the Penn Ohio Golf Trail is, all of the great courses they feature, how we got to know each other and more! Finally, we are now on YouTube! Be sure to search for the Player B podcast and hit subscribe.  As always be sure to follow us on Instagram @Club_Twirl_Ohio and @PunchOutGolf.  Leave us a review on iTunes as we would love to hear from you!  

The Individualist
#6: Special Guest Jared Rabel

The Individualist

Play Episode Listen Later Feb 25, 2021 49:50


In this episode I'm joined by libertarian Jared Rabel, a law student at the University of Baltimore with a bachelor's in Political Science from Salisbury University. We discuss a few controversial topics such as immigration, religion, and abortion as issues themselves and how they're debated within libertarianism, as well as topics we're all familiar with like foreign policy. Find Jared on Twitter @JradRabel His work at libertytalks.net

Nel favoloso mondo di Alice
Il villaggio di Mìrabel

Nel favoloso mondo di Alice

Play Episode Listen Later Feb 24, 2021 2:27


Un villaggio dall'acqua contaminata, una destinazione ignota e una scimmietta

EXPLORING ART
Episode 24| Artist Laetitia “Laeti” Adam-Rabel | The Soul Of Beauty

EXPLORING ART

Play Episode Listen Later Nov 9, 2020 34:26


This Podcast is interview with artist Laetitia “Laeti” Adam-Rabel. Being Haitian descent, Laetitia unique style and her strong well display in her art, redefine the word “beauty”. By expressing self confidence is the true form of beauty.

Midnight Train Podcast
2020 Halloween Murder Special (Sorry, Not Sorry)

Midnight Train Podcast

Play Episode Listen Later Oct 31, 2020 105:40


The Midnight Train Podcast is sponsored by VOUDOUX VODKA.www.voudoux.com Ace’s Depothttp://www.aces-depot.com BECOME A PRODUCER!http://www.patreon.com/themidnighttrainpodcast Find The Midnight Train Podcast:www.themidnighttrainpodcast.comwww.facebook.com/themidnighttrainpodcastwww.twitter.com/themidnighttrainpcwww.instagram.com/themidnighttrainpodcastwww.discord.com/themidnighttrainpodcastwww.tiktok.com/themidnighttrainp And wherever you listen to your favorite podcasts. Subscribe to our official YouTube channel:OUR YOUTUBE Season 4Episode 17Halloween murders Halloween SpecialOur nephewsBeatrice, Lucille and Gertrude When black cats prowl and pumpkins gleam, may luck be yours on Halloween.” — Unknown       Tonight's episode doesn't deal in Halloween luck. Unfortunately it is the exact opposite. We've dealt with murders and murderers in the past. We've brought you the history of Halloween in the past. Who knows what we'll bring you in the future. As for the present, for our Halloween treat to you, we bring you Halloween murders. Some crazy, some sad, some creepy, all on Halloween. Jeff will be happy to know there is no nerdy stuff to start this episode so we're just gonna jump right the fuck into it! Sit back and enjoy these murderous Halloween tales!         We're gonna jump right into the fray here with a pretty brutal story.     Amarillo Texas, October 31 1981: John Frank Garret was a mentally impaired man from Texas. This kid had a super fucked up childhood. He was raped by his stepfather and at one point hired out to another man for sex. At the age of ten… Ten… He was introduced to alcohol and other drugs. This would lead him into serious drug abuse at such a young age which involved amphetamines and paint thinner among other brain damaging drugs. At 14 he was forced to perform degrading sex acts and perform in homosexual porn films. He was regularly beaten and at one time was set on a burner of a stove resulting in terrible scarring. Did we mention that this was all before the age of 17? One of the experts described Garrett's case as "one of the most virulent histories of abuse and neglect I have encountered in over 28 years of practice." On the other side of this  story you have the exact opposite type of person, a nun. 76 year old Sister Tadea Benz lived at the convent right across the street from Garret. On Halloween night she was brutally raped and strangled. Garrett was accused and arrested for the horrific murder. He vehemently denied the accusations set on him. Information on Johnny Frank Garrett's abusive upbringing and mental health problems were not made available to the jury. According to three mental health experts who examined him between 1986 and 1982, Garrett was extremely mentally impaired, chronically psychotic and brain-damaged as the result of several severe head injuries he sustained as a child. He suffered from paranoid delusions, including a belief that the lethal injection would not kill him. Garrett was found guilty and sentenced to death. So, as only Texas would do, A 17 year old mentally impaired boy was convicted and put to death. His defense was widely considered extremely incompetent. Following appeals for clemency from Pope John Paul and the nuns from the victim's convent, then-Governor Ann Richards granted Garrett a rare 30-day executive reprieve. However, after a grossly inadequate clemency hearing, the Texas Board of Pardons and Paroles voted unanimously not to recommend commutation of his death sentence and the execution of Johnny Frank Garrett was allowed to proceed. He was executed by lethal injection on February 11th 1992. His final meal was ice cream. An article from the New York Times the following day summed it up as this: "A month after winning a reprieve from the Governor, a man who raped and killed a Roman Catholic nun when he was 17 years old was executed by lethal injection at the state prison here early today. The execution of the prisoner, Johnny Frank Garrett, 28 years old, came after the United States Supreme Court's rejection of two appeals on Monday night and a third about an hour before he was put to death. Mr. Garrett was convicted of killing Sister Tadea Benz, 76, at the St. Francis Convent in Amarillo in 1981. He came within an hour of execution on Jan. 6 when Gov. Ann W. Richards issued a month's reprieve at the urging of Pope John Paul II. Governor Richards's rare use of her authority to grant a reprieve prompted an equally unusual hearing last week by the Texas Board of Pardons and Paroles to consider whether to recommend to the Governor that Mr. Garrett's sentence be commuted to life. But at the hearing, the board voted by 17 to 0, with one abstention, for the death sentence. Mr. Garrett's case had become the focus of efforts by opponents of the death penalty. The Catholic Diocese of Amarillo, 16 Catholic bishops and the human rights group Amnesty International had opposed his execution. At issue was the contention of his lawyers that Mr. Garrett was insane and suffered from multiple personality syndrome as a result of physical and sexual abuse he had endured as a child. "I think he's simply too crazy to kill," one of those lawyers, Warren Clark, had said. The Supreme Court has ruled that a person who is insane and cannot comprehend an execution or the reasons behind it cannot be put to death. But prosecutors had insisted that while Mr. Garrett might not be normal, he was aware of his crime and understood the punishment.   Mr. Garrett was the 44th killer put to death in Texas since the Supreme Court allowed the resumption of capital punishment in 1976. The total is the highest of any state."  Garrett's last words before he died were as follows "I'd like to thank my family for loving me and taking care of me. And the rest of the world can kiss my ass." which is actually pretty awesome even though it didn't seem like his family loved him much.  But the story doesn't end here. A local lawyer, Jesse Quackenbusch, wasn't really convinced of the guilt of Garrett. Garrett maintained his innocence throughout his ordeal. Quackenbusch believed he had evidence to support that notion. Garrett was originally linked to the crime when his fingerprints were found in the nuns room. The police also claimed a steak knife found in Garrett's house was similar to a weapon found in the driveway of the convent. Hair and semen samples also were collected, but experts testified the samples could not be linked exclusively to Garrett. Quackenbusch also claims that the confession was written by police and not the words of Garrett who refused to sign the confession. Quackenbusch also said that Garrett claims the reason his fingerprints were there was that he was high on lsd one day and broke in and stole a stereo. Quackenbusch also brought up the similarities between the murder of Benz and another murder in the area 3 months prior to the nuns murder. Narnie Box Bryson was a 77 year old woman who was murdered in almost the exact same way as Benz. The similarities were so convincing, in fact, that the district attorney at the time and detectives were convinced the same person committed both murders. Furthermore detectives had concluded that a Hispanic man committed the murders, as well as 8 others in the area,  and black hairs were found at the scenes of both murders, while Garrett was white and had brown hair. Leoncio Perez Rueda was eventually convicted of the murder of Bryson after being linked by a DNA sample taken from semen found on Bryson during her autopsy. The kicker here is that Quackenbusch claimed in recent interviews at the time, Rueda claimed to have raped and killed a nun on Halloween in 1981. Quackenbusch continued his crusade by releasing the documentary "The Last Word" in which he outlines the case for the  innocence of Johnny Frank Garrett. How's that for an appetizer!      October 31, 2010 Sandusky Ohio: 16 year old Devin Griffin came home after singing in a church service that morning. He came home and went up to his room to play video games. He was playing for a little while when he realized that the house was pretty quiet and began to wonder what was up. At around 1:30 in the afternoon he went to investigate and see where his parents were. He walked downstairs to his parents room and found his mom and stepfather in bed with the comforter pulled up over their heads. He started talking to his mother to try and wake her up and tapped her on her leg which was sticking out from the comforter. He got no response. He continued talking to her trying to wake her up and pulled the covers down slightly. As he did this is when he noticed his mother's pillow was soaked in blood. At first he thought this was just a Halloween prank, but slowly the realization set in, this was no prank, they were dead. Devin began to cry and ran from the house. He phoned his aunt in a Panic and she in turn phoned the police. What they would find when they arrived was horrific to say the least.     Investigators found Bill and Susan Liske shot to death in their bed. According to coroner records, Bill Liske was shot five times in the head and face, at a range of about one to two feet. He was lying in a natural sleeping position and had the covers pulled up over him. Susan was sprawled as if she might have been moved, investigators wrote. She was shot three times, again at what investigators suspect was close range. The bullets were small caliber, likely a .22. Upstairs, they found Derek Griffin's, Devon's 23 years old step brother, room locked. Police kicked the door in and found the young man curled up in bed facing the wall. According to the coroner's findings, he suffered blunt force trauma to the head and most likely died within a few minutes of the first blow. Investigators searched and found a bloody claw hammer in the house, which coroners led to be consistent with Derek Griffin's wounds. The weapon and other evidence from around the home were sent to the Ohio Bureau of Criminal Identification and Investigation for forensic testing. Devon Griffin told investigators the family owned lots of guns, many of which authorities seized for testing. They found muddy footprints along a deck near the family's pond, suggesting the suspect may have disposed of the murder weapon in the pond. Authorities drained the pond but found no gun. Weapons-sniffing dogs tracked much of the property and found nothing. One person in the family was missing from all of the carnage, William Liske Jr., Also known as B.J. B.J.s trouble with the family began around 2002 when law enforcement was called to the Liske home because B.J. had threatened to harm himself. According to police records, B.J. Liske attacked the officers when they arrived and faced charges in juvenile court of assaulting a peace officer. Then, in October 2004, B.J. Liske got into a fight with his stepmother and struck her hard in the chest. Two months later police charged him with felonious assault and robbery for allegedly hitting Susan Liske with a coffee cup and stealing her car keys. He was found incompetent to stand trial on those charges, which were eventually dropped. After several more encounters with police B.J. was moved to a Sandusky group home for mental health patients. B.J. and his father got into a physical altercation after William Sr. Picked his son up from the group home. William Liske kicked his son out of the house after. Liske, then 18, attempted to attack Susan Liske as she showered. B.J. did not like his stepmother as she tried to put new rules in place when she married William to try to get the kids under control and bring order to the house as B.J. was acting out because of his parents divorce. Despite all of the issues and a diagnosis of schizophrenia and bipolar disorder, William Sr. sought to get guardianship of B.J. And to try and help his boy. William had taken vacation time and went hunting with B.J. just before the murders. He was with him less than 24 hours before the slaughter at the family's hunting cabin. Neighbors were worried about their safety with B.J. around, but William insisted the family was safe and that "B.J. wouldn't hurt us". The Saturday night before the murders, William and B.J. returned from their hunting trip and had some friends and neighbors over for dinner, beers and a good time. Everyone had fun and things seemed fine. The party broke up around midnight and everyone went to bed with B.J. taking a spot on the couch. According to a neighbor's wife, she thought she heard gunshots around 6:30 am. Devon spent the night at his father's and came home around 9:30 where he encountered B.J. in the home. B.J. asked what devon was up to and how long he'd be gone. He said he was heading to church and that B.J. seemed happy. After this interaction Devon left and B.J. took the family's truck and made his way back to the hunting cabin. He remained there until the police converged on the cabin and took him into custody. B.J. would eventually be convicted of the murders and sentenced to life in prison. In court he blamed his mental illness for the murders saying he doesn't really understand why he did what he did but he loved his father. 4 years later B.J. was found dead in his cell of a self inflicted wound. What a fucking story! —- As a child, What would you have done if someone stole your Halloween candy? What about as an adult? Would you yell? Steal it back? Well, I sure hope you wouldn’t do what this asshole did. Ledell Peoples lost his shit on Halloween night 2011 in a domestic disturbance in Chicago’s South Side that turned pretty nasty. Not able to track down his bag of Hershey’s, Jolly Ranchers and Tootsie Rolls, he accused his partner, 49-year-old Maria Adams, of stealing them from him. As a way of responding to the accusation, she threw a plate at his head. Well, Peoples picked up a knife and repeatedly stabbed her.  She died in hospital and he got 30 years. Over some fucking candy. Jackass. The final victim of the toy box killers Shirley Lynette Ledford was the fifth - and thankfully final - victim of LA serial killers Lawrence Bittaker and Roy Norris. The two men are one of the cruellest serial killing duos ever to disgrace the planet. Known as ‘The Tool Box Killers’ because of their vile and perverted penchant for tool-based torture, the sick pair would often tape-record their crimes. On Halloween night 1979, Bittaker and Norris snatched 16-year-old Shirley from a gas station, where she was hitchhiking home after a Halloween party. They beat her, raped her, tortured her externally and internally with pliers and eventually strangled her with a wire coat hanger. Finally, as a final insult, they dumped her lifeless body on a random front lawn.Both men were caught a month after killing Shirley. They are still imprisoned in maximum security institutions to this day. Both remain unrepentant.  The man who killed Halloween Ever heard the old wives tale about checking your candy for poison or razor blades or small pieces of human remains? Ok, I made that last one up but we’ve all heard the stories. Luckily, it’s bullshit. well, for the most part. Except In Texas in 1974.Ronald Clark O’Bryan laced five Pixy Stix with potassium cyanide, which closely resembles sugar and is highly poisonous, and planned on killing five local kids. Among them, his own son. Why the hell would anyone do this? Well, the plan was to blame the poisonings on a neighbour, see him imprisoned and O’Bryan could collect the insurance policy he’d taken out on his young son. Yeah. He’s a piece of shit.11-year-old Timothy ate his cyanide-filled sour candy on his dad’s suggestion. It had enough poison in it to kill two people. Within an hour he was hospitalised and declared dead. Luckily for the other four children, the quick actions of local detectives figured out what had happened due to the smell on Timothy’s breath and confiscated the other Pixy Stix before they could be eaten.On the 31st of March 1984, Ronald Clark O'Bryan - aka 'The Man Who Killed Halloween' - was rightfully put to death by the state in Huntsville, Texas. As the liquid chemicals entered his veins, a gathering of 300 people shouted ‘Trick or treat!' and threw hard candy at a small group of anti-death penalty protesters. Peter Fabiano It was late on Halloween night of 1957 in Los Angeles.  Beauty shop owner, Peter Fabiano and his wife, Betty were turning out all the lights in their home to go to bed for the night when their doorbell rang.  Mr. Fabiano went downstairs to answer the door, thinking it was a late trick-or-treater.  Mrs. Fabiano, still upstairs, heard her husband ask “Isn’t it late for this sort of thing?”  There was a muffled reply followed by a loud pop and then a thump.  As Betty ran downstairs she heard the squeal of tires on pavement as a vehicle sped off.  She found her husband sprawled on the floor, bleeding from a gunshot wound to the chest.  Mrs. Fabiano called for help, but unfortunately her husband died on the way to the hospital. It took investigators nearly two weeks to identify a person of interest in the case.  The person they named was Joan Rabel, who at one time worked for Mr. Fabiano in his beauty shop.  Rabel had become good friends with Mrs. Fabiano and Betty even lived with Rabel for a short time during which she was having problems in her marriage.  Mr. Fabiano became jealous of the relationship between the two women.  He ultimately decided to work things out with Betty, but there were conditions that had to be agreed to.  Betty was not to ever see Rabel again and to not even say her name in Mr. Fabiano’s presence. Rabel was arrested under the suspicion that she killed Mr. Fabiano because she wasn’t too keen on the demands he made that kept her from seeing Betty.  Rabel denied any involvement saying she was home the whole night and her car in her driveway was proof of that.  This was a partial truth.  In fact, her car was in her driveway the entire night, but after interviewing her acquaintances, detectives learned that she was most definitely not at home.  A friend of hers told investigators that she let Rabel borrow her car that night and that about 37 miles were put on it. When caught in the lie, Rabel admitted that she did borrow the car to get groceries.  With no hard evidence to go on, the police had to let Rabel go. About a month later an anonymous tip was called in about a lockbox in a department store that should be checked.  When officials followed up on the tip they found a .38 caliber gun, which ballistics later confirmed matched the weapon used to kill Mr. Fabiano.  Upon further investigation of sales records at local gun shops, they found that the gun belonged to Goldyne Pizer, a lab technician at an Los Angeles children’s hospital. Pizer was a meek woman and almost immediately confessed to the shooting.  She insisted that it wasn’t her fault, however, and that someone had put her under a “spell”.  That person would turn out to be none other than Joan Rabel. Rabel and Pizer had been good friends, possibly lovers for a few years.  Rabel would always tell Pizer what an awful person Peter Fabiano was.  It became an obsession and their favorite topic of conversation.  Though Pizer didn’t know Mr. Fabiano herself, she began to hate him.  Talk of murder began between the two women and Rabel gave Pizer money to buy a gun. The night of the murder Pizer attempted to disguise herself, wearing a hat, gloves, mask and face paint with the gun hidden in a paper bag.  It was Halloween and wouldn’t look suspicious at all to anyone who may see her. Rabel and Pizer arrived at the Fabiano house around 9 pm and sat outside waiting hours for the lights to be turned off inside the house to make their move.  Pizer went to the door while Rabel waited in the car. After the deed was done, Pizer ran back to the car and when she got inside Rabel kissed her and said “Thank you.”  After dropping the car off Rabel told Pizer “Forget you ever knew me.”  The pair walked off in different directions. Rabel pleaded not guilty.  Pizer claimed insanity.  In the end they each accepted a plea deal for second-degree murder and were sentenced to life in prison. Lisa French This is a rough one.  Halloween night 1973, 9-year-old Lisa French wanted to wear a butterfly costume, but her mother convinced her to wear something a bit warmer for the Fond du lac, Wisconsin weather. Lisa ended up dressing like a hobo.After eating dinner, she ran out of the door and started to trick-or-treat. She made plans to meet up with her friend and go to the Pumpkin Place, a safe area some of the parents had put together for the children. But her friend had gotten in trouble and wasn’t allowed to go. Lisa was left to go out alone.She only made it to three houses that night. The first two, a teacher and a classmate home’s, gave her candy and sent her on her way. The third held more sinister motives.Something was WrongLisa was to be home by 7 pm, and when she didn’t return, her mother started to worry. By the time 10 pm arrived, the neighborhood had already begun searching for the little girl.The neighborhood rallied together, posting signs in their windows, telling others that Lisa was missing. Police started a search party that lasted all night. The next day over 5,000 people joined in and widened the search area.The national guard was called in, and private plane owners volunteered to search from the sky. All-terrain vehicles drove through the marshes, creeks, and fields. All the bodies of water around town had been dragged.A local photoshop printed 6,000 copies of Lisa’s school photo that was passed around and posted throughout town. Gas stations were giving free gas to anyone using a vehicle to search for Lisa. Eventually, a farmer on his tractor found two garbage bags on his property. He stopped and inspected them, finding the body of Lisa French.When the news circulated that Lisa had been found dead, the whole community seemed to mourn her loss. They all came out in support of her family for the funeral.Myron Medin Jr spoke to the mourners who had gathered. “We are here . . . the entire city in spirit is here . . . to share your sorrow.”Turner had been questioned starting the day after Lisa had been reported missing. By elimination, they could prove she had gone to two homes before coming to his, then no one else had seen her. At first, he denied any involvement. But finally, after nine months of being pulled in for questioning, he cracked and confessed. He would change his story during the trial, saying he only confessed to stop the police from harassing him, that he was completely innocent. The story that unfolded was as follows. Turner used to share a duplex with Lisa’s family, so she knew him quite well. When he lived next door, she was fond of talking with him. So nothing would have seemed strange for him to invite her inside that night.After he had Lisa inside, he took her back to his bedroom, where he sexually assaulted her. He claimed that at some point, he realized she wasn’t breathing and tried to resuscitate her. But his girlfriend came home and interrupted him. So he put socks on his hands and moved Lisa’s body into the master bathroom to deal with later.He went out wrapped in a bathrobe, telling his girlfriend he didn’t feel well. While she was there, he kept returning to the bedroom, was he revisiting Lisa’s body?His girlfriend ended up leaving again to go to her mother’s. After she left is when Turner put Lisa’s body in a trash bag and her belongings in another. He took both bags a few miles out of town and dumped them in a field.During the trial, the medical examiner testified about the cause of death. Lisa French died from asphyxiation. But she wasn’t smothered or strangled. She had died due to shock while she was sexually assaulted.The jury found Turner guilty of second-degree murder, enticing a child for immoral purposes and acts of sexual perversion.Robert Owens, the chief psychologist at Taycheedah Correctional Institute, had met with Turner. “He has a cold disregard for people, mainly females. He does not have conscience control to inhibit his impulses for pleasure and to confront to society’s laws.”During his sentencing, Circuit Court Judge Milton saw Turner for who he was. “He impressed me as showing no remorse . . . no feeling of repentance.”It doesn't end there… This dude got released but once but twice. The first time, citizens in the area threatened a civil lawsuit against the state and parole board for allowing the release of a dangerous sex criminal. The authorities admitted their mistake and sent Turner back to prison. But a few years later he was released again for some ridiculous reason. He was fairly quiet for a couple years when a routine parole check uncovered graphic pornography on his computer which was a major cousin. He was then sent back to prison where he sits. He is eligible for parole as of 2018 but had been denied each year since. Here's to hoping this sick fuck never gets out! ALL TRICK, NO TREATWhen 12-year-old trick or treater T.J. Darrisaw knocked on Quentin Patrick's door in the city of Sumter, South Carolina, on Halloween night in 2008 - he expected candy. What he got was 29 bullets through his front door from a fully automatic AK-47. 11 of which hit him, killing him instantly. The poor kid's dad and younger brother were also hit but pulled through and survived. It turns out that Quentin Patrick was a convicted drug dealer that had upset a rival gang of dealers and was fully expecting retribution. What he got was blood on his hands and 30 years inside. This ones not about Halloween, the holiday but… well, you’ll get it. https://m.huffpost.com/us/entry/us_2552173 YOSHIHIRO HATTORI Yoshihiro Hattori was a Japanese exchange student living in Baton Rouge as part of the American Field Service program. On Halloween night 1992, Hattori and the young son of his host family went to a Halloween party for AFS students. Unfamiliar with the neighborhood where the party was, the boys rang the doorbell of the wrong house. When they got no answer, they started walking back to their car. The owner of the home, Rodney Peairs, then opened the door armed with a .44 Magnum. Hattori turned around and said, "We're here for the party." Claiming he feared for his life and that the exchange student was "scary," Peairs shot Hattori, ending his life. Only when both the governor of Louisiana and the Japanese consulate got involved was Peairs arrested, after which he was acquitted of manslaughter. Peairs used the old cake doctrine defense… We think he's just a fucking dick that for away with murder. This last one opens an entirely different can of worms that we plan on discussing in a bonus episode. Chris Jenkins died on Halloween in 2002. He turned up four months later in the Mississippi River still wearing his Halloween costume. Authorities believe his death was an accident or suicide but many people believe he is connected to the Smiley face killer. We don't have the time to get into the Smiley Face Killer theory on this episode but it's pretty crazy and we'll dive into it as a bonus because it's very intriguing. That's the main reason this story made it into this episode… We like to set stuff up… You know foreshadowing and shit.

Pink Collar: A True Crime Podcast
29. Halloween: Joan Rabel and Goldyne Pizer & Helen Pfiel (Halloween Series)

Pink Collar: A True Crime Podcast

Play Episode Listen Later Oct 29, 2020 53:59


Nathalie tells the story of a twisted love triangle (love square?) involving Goldyne Pizer, Betty Fabiano, and Joan Rabel. Betty was having some issues with her husband, Peter, causing her to move in with her “friend” Joan. Back in the 1950s, two women having a romantic relationship was quite taboo. However, Betty reconciled with Peter and moved back in, this made Joan really upset. Joan began seeing Goldyne and during their time together Joan would complain about Betty’s evil husband. Goldyne, desperate to please Joan, dressed up as a superhero and went to the Fabiano residence on Halloween night to murder Peter. Rachel then takes us through the history of Halloween candy poisoning panic. She discusses cases of presumed random Halloween poisonings, including the death of Timothy Marc O’Bryan and Kevin Toston. Next, she moves on to the history of random poisonings, briefly covering the case of the Tylenol murders and the false alarm poisonings of Sunkist Fun Fruits Dinosaur candies. She concludes with the case of a Halloween prank gone wrong. Helen Pfiel of Greenlawn, NY, was getting frustrated with the teens trick or treating in her neighborhood. Helen put together a trick for the teens, instead of candy they would get dog treats, steel wool pads, and ant poison. Helen warned those darn kids they were getting prank treats, but the parents in the neighborhood were not pleased. Helen was arrested for endangering children and received a suspended sentence. Rachel’s Sources https://www.snopes.com/fact-check/halloween-non-poisonings/ https://www.history.com/news/how-americans-became-convinced-their-halloween-candy-was-poisoned https://www.wnycstudios.org/podcasts/radiolab/articles/247053-worse-man-who-poisons-halloween-candy https://gothamist.com/food/halloween-legend-long-island-lady-who-gave-trick-or-treater-arsenic https://www.pbs.org/newshour/health/tylenol-murders-1982 Nathalie's Sources https://www.pleadthebelly.com/noosenotes/2018/10/30/haunted-love-the-story-of-a-deadly-halloween-love-rectangle https://medium.com/the-true-crime-edition/the-trick-or-treat-murder-of-peter-fabiano-151eb6a3983d https://medium.com/true-crime-addiction/unreturned-love-killed-on-halloween-true-crime-e6255ad408d9 https://latimesblogs.latimes.com/thedailymirror/2007/10/they-had-planne.html

On jase de films
23 - Naïla Rabel

On jase de films

Play Episode Listen Later Oct 2, 2020 69:25


En présence de l'influenceuse, militante et actrice Naïla Rabel, on jase du devoir de mémoire qu'est TWELVE YEARS A SLAVE et on poursuit la discussion sur le racisme en abordant le très pertinent documentaire 13TH. Enfin, on se laisse aller dans les contes de princesses avec EVER AFTER! Bonne écoute!

Le cabaret des sorcières
Derrière les Plexiglas

Le cabaret des sorcières

Play Episode Listen Later Sep 23, 2020 78:43


Le Cabaret des sorcières revient en salle sous le signe des mesures sanitaires! Avec Emma Achour, Naïla Rabel aka La grosse qui fait des vidéos, Laura Doyle Péan, Altesse Fumu, Mélissa Lavergne et Marie-Lise Chouinard!

Hosť Andrey Poláčkovej
Erich Rabel - tatér (23.7.2020 13:05)

Hosť Andrey Poláčkovej

Play Episode Listen Later Jul 23, 2020 26:47


E. Rabel: Sú ľudia, ktorí tetovanie berú ako umenie a tí ma zaujímajú. Talkshow Hosť Andrey Poláčkovej pripravuje RTVS - Slovenský rozhlas, Rádio Slovensko, SRo1.

erich slovensko rabel rtvs slovensk sro1
Le cabaret des sorcières
Black lives matter et autres enjeux féministes

Le cabaret des sorcières

Play Episode Listen Later Jun 11, 2020 119:01


La vie reprends son cours et les enjeux sociaux aussi. Ce mois-ci, le Cabaret des sorcières donne la parole à Rim Mohsen, Emilie Ouellette, Naïla Rabel, Julie Artacho et Maude Landry. Avec la participation de Marie-LIvia Beaugé, Gabrielle Brassard Lecours etMarie-Eve Rancourt.nbsp;

Sydney Under the Sun
February Fun: Valentine's, Bachelor, & College Life w/ Maddie Rabel

Sydney Under the Sun

Play Episode Listen Later Feb 17, 2020 51:29


Join Maddie and Sydney as they talk about some fun February things as well as college life and college friendships while on their ski trip! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Assyrian Podcast
Rabel Betshmuel

Assyrian Podcast

Play Episode Listen Later Oct 23, 2018 52:42


Episode 36 - Rabel Betshmuel is an artist who blends modern design with ancient Assyrian art. We discuss his early journey to the United States, his beginnings in art, what inspires him, and what he is doing to nurture and grow the next generation of Assyrian artists. His work can be found on Facebook and Instagram @rabelbetshmuel and at rabelbetshmuel.com

From Cork with Love Adventure
Rebel Story No 4 (Jan 2010)

From Cork with Love Adventure

Play Episode Listen Later Feb 17, 2018 8:00


Precious audio from years ago : A Rebel Story • "Rebel had a pain in his tummy" (Rebel Story No 4 told on 6 January 2010) • Rabel didn't swallow a mouse

Circulation on the Run
Circulation November 7, 2017 Issue

Circulation on the Run

Play Episode Listen Later Nov 6, 2017 18:28


Dr. Carolyn Lam:               Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center, and Duke National University of Singapore.                                                 In just a moment, we will take a deep dive into the issue of age and its association with outcomes of primary prevention ICDs in patients with non-ischemic systolic heart failure.                                                 Yes, a long-awaited discussion from the Danish trial. That, in just a moment. First, here's your summary of this week's Journal.                                                 The first original paper provides evidence of a true association between disturbed genetic imprinting and Preeclampsia. This paper is from co-first authors, Dr. Zadora, and Dr. Singh, and co-corresponding authors, Dr. Izsvak, from the Max Delbrück Center for Molecular Medicine; Dr. Hurst, from the University of Bath; and Dr. Dechend, from the Experimental and Clinical Research Center of Berlin.                                                 These authors performed an unbiased analysis of genome-wide molecular data on raw characterized patient material, from normal controls, and patients with  Preeclampsia, and identified DLX-5 as an imprinted target gene, with novel placental function in Preeclampsia. Due to loss of imprinting, DLX5 was upregulated in 69% of placentas from Preeclampsia patients. Levels of DLX5 correlated with the classical Preeclampsia markers.                                                 DLX5 was expressed in human, but not in urine trophoblast, underlying the known human specificity of Preeclampsia. Finally, DLX5-induced overexpression if trophoblasts faithfully modeled Preeclampsia in a cell culture system. In summary, this paper shows that disturbed imprinting is common, and may play a causal role in Preeclampsia.                                                 The next study affirms that stenosis severity is better discriminated using coronary invasive physiologic indices, than using coronary angiographic assessment. First author, Dr. Lee, corresponding author Dr. Koo, colleagues of Seoul National University Hospital, studied 115 patients with left anterior descending artery stenosis, who underwent both ammonia positron emission tomography, or PET, an invasive physiologic measurement.                                                 Myocardial blood flow measured using PET, and invasively measured coronary pressures, were used to calculate microvascular resistance, and stenosis resistance. They found that both fractional flow reserve, or FFR, and instantaneous weight free ratio, or IFR, decreased as angiographic stenosis severity, resistance, and pressure gradient increased, and hyperemic myocardial blood flow decreased.                                                 When the presence of myocardial ischemia was defined by both low hyperemic myocardial blood flow, and low coronary flow reserve, the diagnostic accuracy of FFR and IFR did not differ, regardless of cutoff values for hyperemic myocardial blood flow, and CFR. However, at any given stratum of a given stenosis, physiologic classification of stenosis severity using FFR or IFR showed better discrimination of a unique relationship between absolute myocardial blood flow, and pressure gradient, than anatomic classification using angiographic percentage.                                                 In summary, by demonstrating coronary physiologic responses to coronary stenosis, these authors showed that stenosis severity is better discriminated, using invasive physiologic indices, than using angiographic assessment.                                                 The next paper identifies a previously unknown angiogenic growth factor that can be enhanced therapeutically to repair the heart after myocardial infarction. This novel growth factor is endoplasmic reticulum membrane complex, Subunit 10, or EMC10, which the authors previously identified by bioinformatic secretome analysis in bone marrow cells.                                                 In the current paper, from co-first authors Dr. [Rabel 00:04:35], and [Krof Clengobill 00:04:37], and corresponding author Dr. Wollert, from Hanover Medical Center, and colleagues, the authors investigated the angiogenic potential of EMC10, and its mouse homologue, in cultured endo fetal cells and infarcted heart explants. They found that EMC10 and its mouse homologue signal a virus, small GTAPases; p21-activated kinase; and p38 mitogen-activated protein kinase, to promote endothelial cell migration.                                                 In mice with acute myocardial infarction, bone marrow derived monocytes and macrophages produced EMC10 endogenously, to enhance infarct vascularization, tissue repair, and heart function. Furthermore, subcutaneous treatment with recombinant EMC10 for one week, after myocardial infarction, augmented infarct vascularization and repair, and led to a sustained improvement in heart function and survival.                                                 The next study is the first prospective randomized trial of screening for atrial fibrillation, with a smartphone-based, single-lead, electrocardiographic system in 1,001 patients, aged 65 years and above, with a CHA2DS2-VASc score of two and above, and without a history of atrial fibrillation.                                                 In this paper, from first and corresponding author Dr. Halcox, from Swansea University Medical School, in the United Kingdom, and colleagues, patients were randomized, either to biweekly electrocardiographic recordings with the iPhone device, or to routine over a 12-month period.                                                 The smartphone-based electrocardiographic approach was at least three times more likely to identify incident atrial fibrillation, than routine care, and at a cost of just over $10,000 per case identified, and was judged to be a highly acceptable approach in this group of patients. These results support consideration of evaluation in an appropriately-powered, event-driven randomized trial, to confirm the clinical and cost effectiveness of such an approach to stroke prevention in atrial fibrillation.                                                 Well, that wraps it up for your summaries. Now for our feature discussion. The Danish trial really created a huge splash last year, when it was reported that a primary prevention ICD in patients with non-ischemic systolic heart failure, may not actually reduce all cause mortality. Something that we had, perhaps, taken for granted, and in fact, entered our guidelines.                                                 Now, however, there was a pre-specified subgroup analysis at the time, that suggested a possible age-dependent association, between ICD and mortality, in the Danish trial. This week, we are so pleased to be discussing an in-depth analysis of the association between age and outcomes in the Danish trial.                                                 I'm so pleased to have the first author of today's featured paper, Dr. Marie Bayer Elming, of Copenhagen, Denmark, as well as Dr. Sana Al-Khatib, who's not only an associate editor of circulation, but also the author of an accompanying, and she is from Duke, Durham, North Carolina. Welcome, ladies! Dr. Bayer Elming:              Thank you. Happy to be here. Dr. Sana Al-Khatib:          Thank you so much. Dr. Carolyn Lam:               Sana, could you start by framing why this paper is so important, and why we've been looking forward in anticipation to these results? Dr. Sana Al-Khatib:          Absolutely. As you know, data on the outcomes of primary prevention ICDs in patients with non-ischemic cardiomyopathy started emerging in the early 2000s, or so. Then in 2005, the sudden cardiac deaths and heart failure trial was published, that included a large number of patients with non-ischemic cardiomyopathy, and absolutely showed survival benefits from primary prevention ICDs in those patients. Of course, there were also patients with ischemic cardiomyopathy.                                                 But really, that trial formed the basis of the guidelines, recommendations, that have informed our practice for the last 12 years, that basically tell us that we should consider implanting a primary prevention ICD in patients with non-ischemic cardiomyopathy, who have an EF of 35% or less, who have Class II or III heart failure symptoms. As long as they are on optimal care at the end, they have a reasonable life expectancy.                                                 So that's what's we've been doing for years, and then, the Danish trial was published this past year, that really called into question the prior findings, and the current practice. Because Danish, as you stated, showed no survival benefit with primary prevention ICDs, but there are many aspects about the trial that people need to pay attention to, to put the results in perspective.                                                 The fact that 58% of patients in the trial, in those arms, received cardiac resynchronization therapy ... the fact that the trial required that patients have an elevated NTproBMB level, to be considered for enrollment ... that may have biased the results toward a higher risk of non-sudden cardiac deaths, so on, so forth.                                                 I think what was really interesting, and caught people's attention, when the paper was published, was this subgroup analysis that showed that younger patients may benefit more than older patients. I think, many of us, Carolyn, were really awaiting the results of a more dedicated analysis, looking at age in Danish, and Dr. Elming and her colleagues did a great job looking at this very closely in their paper, and showed great results, and probably will let Dr. Elming share those results with us. Dr. Carolyn Lam:               Yes, absolutely, Sana. Actually, I just wanted to echo how surprised everyone was, and the immediate thing was, "Oh, my goodness. What do we do with the guidelines?" Maybe we should get back to that later, and Marie, please share with us, what did you do, and what did you find this time? Dr. Bayer Elming:              The reason why we did this study was that, in this main Danish trial, age was the only one of the 13 pre-specified subgroups that had a significant treatment by a subgroup interaction. This suggested that a younger patient might have a survival benefit from ICD ... the implication, even though the overall study was neutral. So we wanted to further investigate this relationship between age and effective ICD implantation.                                                 What we did was to look at the relation between age and effective ICD, and we found that there was this linear relation, for each year of younger age, that was associated with a reduction, a 3% reduction in the hazard ratio, for the benefit of ICD.                                                 Also, we did this selection impact curve, which is a bit technical, but what it does is to describe the expected survival for the population, on as a whole, for the different age cutoffs for ICD treatments.                                                 So, if we take into account, both the patients receiving an ICD, and those who did not, we could see why we would get the highest survival for the population as a whole. What we found was that, when no one in the population received an ICD, around 70% would survive.                                                 If everyone in the population received an ICD, only 72% would survive, but if we chose 70 years as the age cutoff ... so, patients younger than 70 years received an ICD, and patients older than 70 years did not receive an ICD, we got the highest survival for the population, and 75% would survive. Dr. Carolyn Lam:               Thank you, Marie. What important results. So, maybe, still consider ICDs for primary prevention ... in our non-ischemic systolic heart failure, patients were less than 70 years old. Is it as simple as that, Sana? You wrote a beautiful editorial. Tell us, what are the clinical implications? Dr. Sana Al-Khatib:          This is an important question. Danish was an important trial, but in my mind, it truly doesn't refute the role of primary prevention ICDs in patients with non-ischemic cardiomyopathy. As I mentioned earlier, the majority of patients enrolled in Danish received a CRT device. And so, you end up questioning, what does that actually mean, for those patients who are not eligible for cardiac resynchronization therapy?                                                 So, I actually believed that, and as you know, Carolyn, and maybe Marie knows, as well, there have been several meta analyses that have been published, combining data on patients with non-ischemic cardiomyopathy only, and excluding patients with cardiac resynchronization therapy from Danish, that have actually now shown, consistently, a significant improvement in survival, with a primary prevention ICD ... including one that was done by our group.                                                 So, no, I don't think that, based on the results, we should say, "No, we shouldn't be offering primary prevention ICDs to patients with non-ischemic cardiomyopathy," and this beautiful analysis that was done by Marie and her group actually shows that, at least for those patients who are 70 years of age and younger, I think we should absolutely continue to consider them for the therapy, and offer them the therapy, if they're appropriate candidates.                                                 Then, of course, if the patients are older than 70,, and they meet criteria for cardiac resynchronization therapy, I think it will be important for us to be talking to the patients about ... is the RTD with a defibrillator, versus a CRTP only, with a pacemaker, and talking about the pros and cons, and everything else? But in those patients who are older than 70, who don't meet criteria for CRT, I think more research is needed, to really understand the role of primary prevention ICDs in those patients. We definitely need more data there. Dr. Bayer Elming:              I definitely agree that, of course, for the patients older than 70 years were not candidates for CRT treatment. These patients, we do not know very much about 'em, and this study that we did, do not answer that question. Based on the Danish study, and this further analysis of the age inspection, the guidelines in Denmark also state that patients younger than, we say, 68 years, because that was the age cutoff used in the '08 Danish trial, you should definitely think of giving patients with non-ischemic cardiomyopathy an ICD.                                                 But for the older patients, it depends on a variety of co-factors, such as co-morbidity, or frailty, and it should be an individual assessment of the patient. So, I agree with you, Sana. Dr. Carolyn Lam:               That's wonderful. Hey, just one more question. Sana, I'd like you to put on your AE hat, now, and sort of think with me. In circulation, we don't ... well, we're careful about publishing subgroup analyses, so to speak, right, of results. You articulated, in your editorial, reasons why this, perhaps subgroup analysis, may be different from others. Could you elaborate on that a bit? Dr. Bayer Elming:              Yeah, and absolutely, that's a great question. As you pointed out, I mean, you really ... the conventional wisdom in clinical research is to be careful, interpreting subgroup analyses. I think there are some strengths in this particular analysis, as Marie stated: "Here's what we specified." The other thing is, I believe that Marie and her group then came, and did their very robust statistical methods, and really, probably most importantly, if you look at their findings, they actually really align well, and support their main conclusion.                                                 For example, looking at the fact that older patients had the higher presence of co-morbidities, that they had a higher level of [Co-BMP 00:17:00], they had had a longer duration of heart failure ... I mean, all those things most likely had an impact on their mode of death, really making it more likely for those patients to succumb to non-sudden cardiac death. I think the whole story makes a lot of sense. Dr. Bayer Elming:              If I can elaborate a bit on this, I think one of the important findings from the study is that we show that mode of death varied according to age. So, the rates of sudden cardiac death were almost similar, between the younger and the older part of the population. But the rates of non-sudden death were almost twice as high in the older part of the population. This is a really good explanation why the ICD implantations have less impact in the older patients. Dr. Carolyn Lam:               Yeah, because ICDs would definitely not be expected to reduce non-sudden cardiac deaths. Really, really, well put. Oh, thank you so much, Marie. We're so proud to be publishing your beautiful paper, as well as your editorial, Sana, and thank you for this great conversation.                                                 Well, listeners, I'm sure you enjoyed that as much as I did. Thank you for joining us this week, and don't forget to tune in next week.

GUY WEWE SHOW
S.O.S JEAN RABEL: MAJISTRA NORVILUS EBRULE DUVENS AP PALE DE PASAJ MATTHEW (INTERVIEW ESKLIZIF)

GUY WEWE SHOW

Play Episode Listen Later Oct 4, 2016 11:40


S.O.S JEAN RABEL: MAJISTRA NORVILUS EBRULE DUVENS AP PALE DE PASAJ MATTHEW (INTERVIEW ESKLIZIF) by GUY WEWE RADIO A

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