Podcasts about ion channel

Mutations affecting ion channels are the most common cause of 'applications for treatment' submitted to n-Lorem. These channels regulate the passage of essential electrically charged ions, like sodium, potassium, calcium, and chloride, into cells. Alas, ion channels pose a significant challenge in the ASO discovery process, as there is little room for error due to the need for highly allele-selective ASOs to achieve success. Let's 'dive into the channel' and explore the complexities of treating patients with ion channel mutations.Recently a report on one of our patients with an ion channel mutation was published in Endpoints News highlighting the power of our technology for these disorders. Check it out by clicking the link below.Endpoints News (endpts.com) A teenager faced constant seizures. Could a drug developed just for him stop them?Podcast Awards - The People's ChoiceSurvey – Patient Empowerment Program PodcastRegister for the 2024 Nano-rare Patient ColloquiumOn This Episode We Discuss:Defining Ion Channels and IonsHealth, Homeostasis, and Biological BufferingMultiple forms of the same geneMultiple Isoforms of Gene Product from the same geneNetwork redundancyIon Channels are different

Ion channel block unraveled Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takashi Sumikama at the Kanazawa University NanoLSI in collaboration with Katsumasa Irie from Wakayama Medical University and colleagues.The research described in this podcast was published in Nature Communications in July 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Ion channel block unraveledResearchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes. Structural analysis and computer simulations made it possible to identify where and why calcium ions get stuck. Ion channels are structures within cell membranes that enable specific ions to travel to and from the cell. Such transfer is essential for a variety of physiological processes like muscle cell contraction and nerve excitation. In so-called tetrameric cation channels, the ion selectivity results from the unique structural and chemical environment of the part referred to as the selectivity filter, which is located between two intertwined helical structures. Tetrameric ion channels are prone to ‘divalent cation block', the blocking of the channel by ions like calcium (as in Ca2+). Such blocking regulates the ionic current, which is involved in various neural activities such as memory formation. How divalent cation block happens exactly is still unclear at the moment — in particular, a direct observation of the cation actually blocking the ion pathway has not been reported yet. Now, Takashi Sumikama from Kanazawa University in collaboration with Katsumasa Irie from Wakayama Medical University and colleagues has discovered the mechanism behind divalent cation block in NavAb, a well-known tetrameric sodium (Na) channel. Through structural analysis and computer simulations, the researchers were able to reveal the relevant structural features and molecular processes at play.So how did they go about this structural analysis?NavAb is a sodium channel cloned from a bacterium (Arcobacter butzleri) and has a well-known structure. Sumikama and Irie's colleagues performed experiments with NavAb and three mutants. The structures of the mutants were determined for environments with and without calcium. The scientists focused on the differences in electron densities for the different structures, as these provide insights into the locations of the calcium ions. They found that for the mutants displaying calcium blocking, one or two calcium ions are located at the bottom of the selectivity filter. They also discovered that two other divalent cations — magnesium (as in Mg2+) and strontium (Sr2+) ions — blocked the calcium-blocking mutant sodium channels.The researchers then performed computer simulations to obtain a detailed understanding of the interaction between the calcium ions and the mutated NavAb channels. The simulations reproduce the dynamics of ions passing — or not passing — the channel. In the absence of calcium ions, sodium ions were observed to penetrate the channel. In the presence of calcium ions, penetration significantly decreased in the calcium-blocking mutants. The simulations also confirmed that the blocking calcium ions are ‘stuck' at the bottom of the selectivity filter, and revealed that this ‘sticking' is related to the increased hydrophilicity (affinity to water) of relevant structural parts of the mutated channels.The results of Sumikama and Irie's colleagues provide an important step forward towards a full understanding of the mechanism of divalent cation block in NavAb, an important and representaNanoLSI Podcast website

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.06.547946v1?rss=1 Authors: Hori, Y., Nagai, Y., Hori, Y., Oyama, K., Mimura, K., Hirabayashi, T., Inoue, K.-i., Fujinaga, M., Zhang, M.-R., Takada, M., Higuchi, M., Minamimoto, T. Abstract: Chemogenetic tools provide an opportunity to manipulate neuronal activity and behavior selectively and repeatedly in nonhuman primates (NHPs) with minimal invasiveness. Designer Receptors Exclusively Activated by Designer Drugs are one example that is based on mutated muscarinic acetylcholine receptors. Another channel-based chemogenetic system available for neuronal modulation in NHPs uses Pharmacologically Selective Actuator Modules (PSAMs), which are selectively activated by Pharmacologically Selective Effector Molecules (PSEMs). To facilitate the use of the PSAM/PSEM system, the selection and dosage of PSEMs should be validated and optimized for NHPs. To this end, we used a multimodal imaging approach. We virally expressed excitatory PSAM (PSAM4-5HT3) in the striatum and the primary motor cortex of two macaque monkeys, and visualized its location through positron emission tomography (PET) with the reporter ligand [18F]ASEM. Chemogenetic excitability of neurons triggered by two PSEMs (uPSEM817 and uPSEM792) was evaluated using [18F]fluorodeoxyglucose-PET imaging, with uPSEM817 being more efficient than uPSEM792. Pharmacological magnetic resonance imaging showed that increased brain activity in the PSAM4-expressing region began approximately 13 min after uPSEM817 administration and continued for at least 60 min. Our multimodal imaging data provide valuable information regarding the manipulation of neuronal activity using the PSAM/PSEM system in NHPs, facilitating future applications. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.14.532536v1?rss=1 Authors: Rolland, L., Faucherre, A., Mancilla Abaroa, J., Drouard, A., Jopling, C. Abstract: Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to pathological hypertrophy and heart failure. Conversely, in response to extensive myocardial damage, cardiomyocytes in the adult zebrafish heart and neonatal mice proliferate and completely regenerate the damaged myocardium. We therefore hypothesized that in adult zebrafish, changes in mechanical loading due to myocardial damage may act as a trigger to induce cardiac regeneration. Based, on this notion we sought to identify mechanosensors which could be involved in detecting changes in mechanical loading and triggering regeneration. Here we show using a combination of knockout animals, RNAseq and in vitro assays that the mechanosensitive ion channel Trpc6a is required by cardiomyocytes for successful cardiac regeneration in adult zebrafish. Furthermore, using a cyclic cell stretch assay, we have determined that Trpc6a induces the expression of components of the AP1 transcription complex in response to mechanical stretch. Our data highlights how changes in mechanical forces due to myocardial damage can be detected by mechanosensors which in turn can trigger cardiac regeneration. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The latest sponsored DDW Sitting Down With podcast features Dr Michael Morton, Director and Co-founder, ApconiX, and Dr Kimberly Rockley of ApconiX who discuss the benefits of early ion channel screening. The podcast covers the hERG ion channel and its importance in cardiac safety screening in drug discovery. Morton and Rockley outline the options available, the advantages of these approaches and how the results of hERG should and could be used to inform the drug discovery pathway. Listen now.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.03.530963v1?rss=1 Authors: Van Renterghem, C., Nemecz, A., Delarue-Cochin, S., Joseph, D., Corringer, P.-J. Abstract: Using a bacterial orthologue of brain pentameric neurotransmitter receptors, we show that the orthotopic/orthosteric agonist site and the adjacent vestibular region are functionally inter-dependent in mediating compound-elicited modulation. We propose that the two sites in the extracellular domain are involved ''in series'', a mechanism which may have relevance to Eukaryote receptors. We show that short-chain di-carboxylate compounds are positive modulators of GLIC. The most potent compound identified is fumarate, known to occupy the orthotopic/orthosteric site in previously published crystal structures. We show that intracellular pH modulates GLIC allosteric transitions, as previously known for extracellular pH. We report a caesium to sodium permeability ratio (PCs/PNa) of 0.54 for GLIC ion pore. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.07.523089v1?rss=1 Authors: Zhu, J., Xian, Q., Hou, X., Wong, K. F., Zhu, T., Chen, Z., He, D., Kala, S., Jing, J., Wu, Y., Zhao, X., Li, D., Guo, J., Qiu, Z., Sun, L. Abstract: Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the advantages of non-invasiveness, deep penetration, and high spatiotemporal accuracy. However, the underlying biological mechanism of ultrasonic neuromodulation remains unclear, hindering the development of efficacious treatments. Here, the well-known Piezo1, was studied through a conditional knockout mouse model as a major molecule for ultrasound neuromodulation ex vivo and in vivo. We showed that Piezo1 knockout in the right motor cortex of mice significantly reduced ultrasound-induced neuronal calcium responses, limb movement and muscle EMG responses. We also detected higher Piezo1 in the central amygdala (CEA) which were found more sensitive to ultrasound stimulation than that of cortex. Knocking out the Piezo1 in CEA neurons showed a significant reduction of response under ultrasound stimulation while knocking out astrocytic Piezo1 showed no obvious changes in neuronal responses. Additionally, we excluded an auditory confound by monitoring auditory cortical activation and using smooth waveform ultrasound with randomized parameters to stimulate P1KO ipsilateral and contralateral regions of the same brain and recording evoked movement in the corresponding limb. Thus, we demonstrate that Piezo1 is functionally expressed in different brain regions, and that it is an important mediator of ultrasound neuromodulation in the brain, laying the ground for further mechanistic studies of ultrasound. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.29.518405v1?rss=1 Authors: Hernandez-Ortego, P., Torres-Montero, R., de la Pena, E., Viana, F., Fernandez-Trillo, J. Abstract: TRPM8 is a non-selective cation channel expressed in primary sensory neurons and other tissues, including prostate and urothelium. Its participation in different physiological and pathological processes such as thermoregulation, pain, itch, inflammation and cancer has been widely de-scribed, making it a promising target for therapeutic approaches. The detection and quantification of TRPM8 seems crucial for advancing in the knowledge of the mechanisms underlying its role in these pathophysiological conditions. Antibody-based techniques are commonly used for protein detection and quantification, although their performance with many ion channels, including TRPM8, is suboptimal. Thus, the search for reliable antibodies is of utmost importance. In this study, we characterized the performance of six TRPM8 commercial antibodies in three immuno-detection techniques: western blot, immunocytochemistry and immunohistochemistry. Different outcomes were obtained for the tested antibodies; two of them proved to be successful detecting TRPM8 in the three approaches while, in the conditions tested, the other four were acceptable only for specific techniques. Considering our results, we offer some insight into the usefulness of these antibodies for detection of TRMP8 depending on the methodology of choice. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This episode is also available as a blog post: https://mdforlives.blog/2022/03/10/ion-channel-may-link-hyperglycemia-to-clotting-risk-in-diabetes/ --- Send in a voice message: https://anchor.fm/mdforlives/message

Tomorrow, Tuesday's LIVE show will be later than todays' was…more than likely 12NOON-3PM ET, 9AM-12NOON PT!  IF it's different, I'll let you know! It IS The Season!  The Music Authority LIVE STREAM Show & Podcast...listen, like, comment, download, share, repeat…heard daily on Podcahser, Deezer, Amazon Music, Audible, Listen Notes, Google Podcast Manager, Mixcloud, Player FM, Stitcher, Tune In, Podcast Addict, Cast Box, Radio Public, and Pocket Cast, and APPLE iTunes! MORNINGS IN CANADA!  https://s1.citrus3.com:2000/public/HCRRadio  Hamilton Co-Op Radio!  Follow the show on TWITTER JimPrell@TMusicAuthority!  Are you listening? How does and can one listen in? Let me list the ways...*Listen LIVE here - https://fastcast4u.com/player/jamprell/ *Podcast - https://themusicauthority.transistor.fm/   The Music Authority LIVE STREAM Show & Podcast!  Special Recorded Network Shows, too!  Different than my daily show! *Radio Candy Radio Monday Wednesday, & Friday 7PM ET, 4PM PT*Rockin' The KOR Tuesday, Wednesday, and Thursday at 7PM UK time, 2PM ET, 11AM PT  www.koradio.rocks*Pop Radio UK Friday, Saturday, & Sunday 6PM UK, 1PM ET, 10AM PT!December 20, 2021, Monday, set three…The Connection - 03 Christmas Bells Are Ringing [A Christmas Gift For]John Prine - Silent Night All Day LongSleeping At Last - Christmas, Baby Please Come Home@Swingerhead - The Christmas WaltzRogers & Butler - Noel Coward [Poets & Sinners] (Zip Records)@Quint feat Karen Basset - Beaus Of Holly [Soundtrack of the ION Channel movie “Beaus Of Holly”]Cirrone Band - Christmas Sun@The New Favourites - 01 Underneath The Christmas Tree [Happy Holidays From The Co-Op Communique]JD McPherson - Twinkle [Paste Holiday Sampler 2012]Sister Hazel - White ChristmasTad Overbaugh - Bill Stares At The TV [Open Road & Blue Sky] (Rum Bar Records)The Brothers Steve - 02  I Love The Christmastime [Big Stir Singles The Yuletide Wave] (Big Stir Records)@Somerdale - Merry Christmas Time [Maggie Says It Again] (Jem Records)Johnny Mercer With @Margret Whiting - Baby, It's Cold OutsideDana Countryman - Take A Little Chance [Come Into My Studio]Frank Sinatra - We Wish You A Merry ChristmasLos Straightjackets - 11 Christmas Weekend [The Complete Christmas Songbook]@Joyce Church - 03 Silver Bells [Songs Of Christmas]Neal Sawyer- A Christmas SongGas House Gorillas - Come Back, Baby (It's Christmas After All) (@Stoopid Brute Records)

Could this natural drug and alcohol alternative, also known as the "Sober Psychedelic", transform the future of mental health? Cameron George, the founder of TRU KAVA, joins us this week to share the fascinating history behind Kava, how it's impacting our brains and mental health status and why he's on a mission to set the industry standard for quality, safety and education around kava within the mass market. TRU KAVA is focused on developing user-friendly products that deliver the full therapeutic action of the traditional kava drink, which is the only form that has been highly prized in the south pacific islands for over 3000 years.SHOW NOTES: 0:53 Welcome to the show!2:36 Cameron George's Bio3:38 Welcome Cameron!4:36 What is Kava?7:08 Cameron's health journey14:40 Concerns with Benzodiazepines16:13 *Kion – Save 15% with code BioBabes1517:20 Looking for a plant-based alternative20:36 An increase in social connection & introspection22:50 GABA receptor upregulation26:12 Why is Kava good for so many things?31:10 Kava as “The Great Protector”34:40 The GABA pathway35:48 Ion-Channel blocking, COX-1 & COX-2 inhibitION37:04 Nrf2 upregulation for anti-oxidation37:28 Processing emotional traumas & stress38:13 How the indigenous people use it42:09 *LightPath LED – Save 5% with code BIOHACKERBABES45:12 Lauren's first experience with Kava46:45 The different strains available50:30 Newest product coming soon53:07 Cultures that embrace psychedelics55:32 His final piece of advice58:20 Thanks for tuning in!RESOURCES: GetTruKava.comInstagram: @TruKavaFacebook: Tru KavaKion - Save 15% with code BioBabes15LightPath LED - Save 5% with code BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donations

JC Herz is the COO of Ion Channel, a software logistics and supply chain assurance platform for critical infrastructure. She is a visiting fellow at George Mason's National Security Institute and co-chairs a Department of Commerce working group on software bills of materials for security-sensitive public and private sector enterprises. JC and Steve Springett join  to talk all things software bill of materials. We define what an SBOM is and what it's used for. We talk threats that SBOM counters, who started it, and what the OWASP tie in. JC concludes our time by explaining why now is the time YOU must care about SBOMS. We hope you enjoy this conversation with…. JC Herz and Steve Springett.

We're fulfilling a promise made three years ago on our very first Christmas episode by bringing back #FiFiFierce to discuss the 2017 Ion Channel original Christmas movie Snowmance. Join in as we discuss the cast's extensive Christmas movie resumes, lutefisk, lazy magazine ideas, and the uncomfortable idea of kissing a snowman. Plus: How old is Cole? Are all snowmen sentient? Why is Will fighting with Hoopla? And when will Fiona update her chicken tender blog? Make sure to rate, review, and subscribe! Next week: The Santa Clause 2 (2002) --- Send in a voice message: https://anchor.fm/we-love-the-love/message

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.21.104976v1?rss=1 Authors: Chopra, R., Bushart, D., Cooper, J., Yellajoshyula, D., Morrison, L., Huang, H., Scoles, D., Pulst, S. M., Orr, H., Shakkottai, V. Abstract: Selective neuronal vulnerability in neurodegenerative disease is poorly understood. Using the ATXN1[82Q] model of spinocerebellar ataxia type 1 (SCA1), we explored the hypothesis that regional differences in Purkinje neuron degeneration could provide novel insights into selective vulnerability. ATXN1[82Q] Purkinje neurons from the anterior cerebellum were found to degenerate earlier than those from the nodular zone, and this early degeneration was associated with selective dysregulation of ion channel transcripts and altered Purkinje neuron spiking. Efforts to understand the basis for selective dysregulation of channel transcripts revealed modestly increased expression of the ATXN1 corepressor Capicua (Cic) in anterior cerebellar Purkinje neurons. Importantly, lentiviral overexpression of Cic in the nodular zone accelerated both aberrant Purkinje neuron spiking and neurodegeneration. These findings reinforce the central role for Cic in SCA1 cerebellar pathophysiology and suggest that only modest reductions in Cic are needed to have profound therapeutic impact in SCA1. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.19.101196v1?rss=1 Authors: Yoo, S., Mittelstein, D. R., Hurt, R. C., Lacroix, J. J., Shapiro, M. G. Abstract: Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification. However, the biomolecular and cellular mechanisms by which focused ultrasound excites mammalian neurons have remained unclear, posing significant challenges for the use of this technology in research and potential clinical applications. Here, we show that focused ultrasound excites neurons through a primarily mechanical mechanism mediated by specific calcium-selective mechanosensitive ion channels. The activation of these channels results in a gradual build-up of calcium, which is amplified by calcium- and voltage-gated channels, generating a burst firing response. Cavitation, temperature changes, large-scale deformation, and synaptic transmission are not required for this excitation to occur. Pharmacological and genetic inhibition of specific ion channels leads to reduced responses to ultrasound, while over-expressing these channels results in stronger ultrasonic stimulation. These findings provide a critical missing explanation for the effect of ultrasound on neurons and facilitate the further development of ultrasonic neuromodulation and sonogenetics as unique tools for neuroscience research. Copy rights belong to original authors. Visit the link for more info

JC Herz, national expert on open-source software and COO and founder of Ion Channel, discusses how open-source code makes up around 80 percent of all proprietary business software. If that code doesn't come from a reliable source or a consistent committer, it can result in huge security problems for consumers.

The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Tracing Ebola virus contacts(CIDRAP) WHO FAQ Ebola virus vaccine(WHO) Nipah virusoutbreak (CIDRAP) Revealingparasitoid to hyperparasitoid (PNAS) Hyperparasitoidvideo (YouTube) Calcium channeland influenza virus entry (Cell Host Microbe) Letters readon TWiV 495 Weekly Science Picks Alan - National Cryptologic Museum Rich - Science is mostly about staring Dickson - New Zealand gloworms Kathy - Openingof Smithsonian Outbreak; conference advice General ASV Vincent - ICTV online Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Technology entrepreneur JC Herz talks about what it takes to build a scalable cyber security enterprise software business, how to raise venture capital, and her transition from journalist to pioneering big data geek as the COO of Ion Channel. A Crossfit expert and enthusiast, JC shares her lessons learned…from her time on the Harvard men’s crew team … and beyond. More at https://wingspodcast.com Review WINGS on iTunes and win a chance to Mastermind in person one-on-one with host and entrepreneur Melinda Wittstock Like WINGS! https://facebook.com/wingspodcast Follow us on Twitter @MelindaWings Our sponsors: Your Return on Authenticity™: Apply for Verifeed’s social media accelerator  Springboard Enterprises: The Accelerator for Female Founders Zero Limits Ventures: Valuation Enhancement and Capital Acquisition Strategies

Scott Earley explains how reactive oxygen species activate TRPA1 ion channels to trigger dilation of cerebral arteries.

Scott Early talks about a pressure-sensitive signaling pathway that maintains constant blood flow to the brain.

Geoffrey Abbot discusses how a potassium channel and a small molecule transporter cooperate to regulate the composition of cerebrospinal fluid and seizure susceptibility.

Tue, 1 Oct 2013 12:00:00 +0100 https://epub.ub.uni-muenchen.de/22757/1/oa_22757.pdf Strupp, Michael ddc:61

Diomedes Logothetis and Rahul Mahajan explain how G proteins activate a potassium channel to slow heart rate.

Brian Button discusses a feedback mechanism for insuring the proper hydration of airway mucus.

Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.

Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.

Dr Liz Carpenter talks about her research on membrane proteins and drug development. Membrane proteins are the gateways to our cells - with nutrients, waste products, and even DNA and proteins entering and leaving cells via these tightly controlled proteins. Drugs often target membrane proteins; therefore, understanding their molecular structure helps us design better drugs. Dr Liz Carpenter uses X-ray crystallography to solve membrane protein structures. This information is then used to improve treatments for heart disease and neurological diseases.

TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore forming domains of TRPML and TRPV5/TRPV6 channels have similarities that indicate possible functional interactions between these TRP channel subfamilies. Here we show that TRPML3 and TRPV5 associate to form a novel heteromeric ion channel. This novel conductance is detectable under conditions that do not activate either TRPML3 or TRPV5. It has pharmacological similarity with TRPML3 and requires functional TRPML3 as well as functional TRPV5. Single channel analyses revealed that TRPML3 and TRPV5 heteromers have different features than the respective homomers, and furthermore, that they occur in potentially distinct stoichiometric configurations. Based on overlapping expression of TRPML3 and TRPV5 in the kidney and the inner ear, we propose that TRPML3 and TRPV5 heteromers could have a biological function in these organs.

In this NewsFlash, we discover the role quartz plays in making mountain ranges, celebrate MESSENGER going successfully into orbit around Mercury, and explore the reasons why birds fly into obvious objects. Plus, how progesterone excites sperm - we explore the role of a sperm-specific protein that could lead the way to a new contraceptive!

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Integrating interactome and genetics data allows researchers to predict adverse drug effects.

Enhanced Video PodcastAired date: 4/27/2009 12:00:00 PM Eastern Time

Enhanced Audio PodcastAired date: 4/27/2009 12:00:00 PM Eastern Time

Enhanced Video PodcastAired date: 12/1/2008 12:00:00 PM Eastern Time

Enhanced Audio PodcastAired date: 12/1/2008 12:00:00 PM Eastern Time