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What happens when two driven twin-brothers stop playing small and go all-in on their vision?Dr. Stephen sits down with Dr. Michael and Dr. David Hughes to unpack how they transformed Gateway Family Chiropractic from a modest local practice into a multi-million-dollar, multi-location enterprise utilizing the TRP System. They talk about moving from indecision to clarity, from being coached to becoming leaders, and from holding onto old systems to embracing a scalable business model through The Remarkable Practice. This episode is Part 1 of the Hughes Brothers story, Part 2 will tell of the incredible acquisition-driven expansion of the Hughes Empire utilizing the TRP Systems. Their story offers a real-life look at the power of commitment, the importance of alignment in leadership, and the role systems play in sustainable growth.In this Case Study you will:Hear why their old coaching program couldn't keep up with their VisionLearn how implementing TRP systems helped them double their practiceUnderstand the role of the COO in operational breakthroughsDiscover how they're creating long-term succession with their familyGet inspired by their plans to expand across Colorado and Texas Episode Highlights01:23 – What caused them to leave their original coaching program and start looking elsewhere04:07 – Why their first encounter with TRP felt overwhelming—and how they handled it04:40 – The decision they made that shifted everything in their business trajectory05:47 – A surprising leadership move that helped them finally implement what mattered06:34 – What happened when they invited their whole team into the training process07:25 – The revenue story behind their growth and the numbers they saw at each stage10:01 – The personal values that influenced who they chose to work with12:25 – How the next generation of their family is getting involved in the business14:19 – What one family member secretly aspires to become in the TRP ecosystem15:13 – How they're navigating acquisitions—and what they look for in potential opportunities17:42 – What they're doing now to make sure they always have great people in place18:44 – A unique online strategy they're using to attract top-tier chiropractic talent19:06 – How they reframe hiring so it becomes a powerful form of marketing20:12 – Where they're expanding next and how they're making it sustainable21:37 – The unexpected source of inspiration that shaped their multi-location vision26:14 – What challenge they're facing now and how they're preparing to solve it28:46 – What they'd tell their earlier selves before joining TRP31:49 – Why they believe growth never stops—and how TRP keeps up with them33:15 – What surprised them about the values running beneath TRP's business systems34:45 - Success Partner, Dr. Erik Kowalke, founder and CEO of SKED joins Dr. Chris to discuss how technology is transforming chiropractic care. Dr. Erik shares how SKED simplifies patient communication, reduces missed appointments, and helps practices increase their impact. Tune in to learn how SKED's innovative solutions can streamline your operations and help spread the power of chiropractic further than ever before. Resources MentionedTo learn more about the REM CEO Program, please visit: http://www.theremarkablepractice.com/rem-ceoFor more information about SKED please visit: https://sked.lifeSchedule a Brainstorming call with Dr. PeteFollow Dr Stephen on Instagram: https://qr.me-qr.com/l/riDHVjqt Follow Dr Pete on Instagram: https://qr.me-qr.com/I1nC7Hgg Prefer to watch? Catch the podcast on YouTube at: https://www.youtube.com/@TheRemarkablePractice1To listen to more episodes visit https://theremarkablepractice.com/podcast/ or follow on your favorite podcast app.
We're doing a fair use and transformative reading of part of an essay in one of my favorite publications. This is an engagement with an essay by TRP podcast guest Charles R. Kesler and one of my favorite writers on American Politics entitled "America's Red Shift" in Fall 2024 Claremont Review of Books. Kesler was also one of my Ph.D. professors at Claremont Colleges (4 courses). We want to thank Claremont Review of Books for making this material available. Go to ClaremontReviewofBooks.com to subscribe for a very reasonable price and get the hard copies with aesthetically pleasing artwork and thoughtful though accessible essays in your physical mailbox. The Republican Professor is a pro-Claremont-Review-of-Books podcast. The Republican Professor is produced and hosted by Dr. Lucas J. Mather, Ph.D.
CAT1RB5535-17061995-10062024transmutation (organs) -/- experimentation (metal)Incident Elements:· graphic descriptions of post-mortem examinationTranscripts available at https://rustyquill.com/transcripts/the-magnus-protocol/You can find a complete list of our Kickstarter backers https://rustyquill.com/the-magnus-protocol-supporter-wall/Created by Jonathan Sims and Alexander J Newall Directed by Alexander J NewallWritten by Alexander J NewallScript Edited with additional material by Jonathan SimsExecutive Producers April Sumner, Alexander J Newall, Jonathan Sims, Dani McDonough, Linn Ci, and Samantha F.G. Hamilton Associate Producers Jordan L. Hawk, Taylor Michaels, Nicole Perlman, Cetius d'Raven, and Megan Nice Produced by April SumnerFeaturing (in order of appearance) Lowri Ann Davies as Celia RilpleyAnusia Battersby as Gwen BouchardSarah Lambie as Lena KelleyBillie Hindle as Alice DyerRobert Vernon as Heinrich UnheilmichDialogue Editor – Nico VetteseSound Designer – Meg McKellar Mastering Editor - Catherine RinellaMusic by Sam Jones (orchestral mix by Jake Jackson) Art by April Sumner SFX from Soundly and Freesound: martinimeniscus, fransiscopcoutinho, TRP, jberkuta14, Uk by Darkproductions_2016, iggy1345, kyles, unkleceeg, Greg_surr, alec_mackay, MWsfx. Additional sounds by Tessa Violet as well as previously credited artists.Check out our merchandise available at https://www.redbubble.com/people/RustyQuill/shop and https://www.teepublic.com/stores/rusty-quillSupport Rusty Quill by purchasing from our Affiliates;DriveThruRPG – DriveThruRPG.comJoin our community:WEBSITE: rustyquill.comFACEBOOK: facebook.com/therustyquillX: @therustyquillEMAIL: mail@rustyquill.com The Magnus Protocol is a derivative product of the Magnus Archives, created by Rusty Quill Ltd. and licensed under a Creative Commons Attribution Non-Commercial Share alike 4.0 International Licence. Hosted on Acast. See acast.com/privacy for more information.
In this Telugu Podcast episode, we had an eye-opening conversation with Suresh Kochattil garu, who's been in the media industry for 40 yrs & 17 yrs of experience at Times of India in various levels. As the world drowns in breaking news, social media headlines, and sensationalism, This episode takes you through the actual machinery that runs Indian media. Starting with a simple question: is the printing press as dramatic as it's shown in the movies? The truth, as always, is far more layered. From how news is selected, printed, and distributed, to why newspaper stories cut off after 12 PM, we explored the real-time walkthrough of what really goes on behind those bold headlines.The episode then dives into one of the most defining moments of Indian media urgency—the assassination of Rajiv Gandhi in Sriperumbudur. How that single moment changed reporting patterns and led to a media that thrives on speed rather than depth. But this conversation is not just about journalism. It's about truth, control, perception, and the massive war of narratives we're all part of, knowingly or not.We explored how India often wins on the battlefield but loses in the eyes of the world because of poor narrative management. In contrast, countries like Qatar have silently reshaped their global image—through airlines, global sports, news networks, and funding major universities. From Al-Jazeera to the FIFA World Cup, narrative power is everything. And while that happens globally, at home, politicians are allegedly buying YouTube channels for ₹8-9 crores to push their version of reality.We didn't just stop there. We delved into the dark alleyways of the Indian underworld—gold smuggling routes, Calicut's Kondotty village, and how dons moved into real estate after using heroines and music labels as money fronts. He talked about bomb blasts, NSG failures, the Bhatkal brothers, and how stories were buried before ever being told. He opened up about the deaths of icons like Lal Bahadur Shastri and cases like Nagarwala, where ₹60 lakhs were withdrawn from SBI based on a phone call impersonating the Prime Minister.Even the names of Hyderabad's localities—Tarnaka, Musarambagh, Bolaram—carry centuries of untold stories, which were brought to life with stunning clarity. We spoke about the TRP race, the death of press conferences, and how public discourse has shifted from dinner table conversations to manipulated debate shows. The impact of “WhatsApp journalism,” sensationalism, and psychological conditioning through repetitive negative news is unpacked with startling precision.As the media landscape tilts further into noise and chaos, This discussion calls for a revival of real, fearless journalism. He expresses his admiration for Karan Thapar, Ramnath Goenka, and Ramoji Rao—figures who once stood for truth despite the odds. He reflects on why journalists today are either demonized or silenced, and how stringers are forced into unethical shortcuts due to low wages and pressure.Ending on a powerful and emotional note, he shares life lessons from his father, a man of honesty and principle, and offers his heartfelt advice to the youth of India. In a world where everyone is fighting to be heard, this episode reminds us that sometimes the most powerful thing we can do is simply speak the truth.
Join the Trudge Report duo this week as Shawn and Greg bring you a wonderful guest speaker to the show. TRP welcomes Timmy Mac. Timmy has been a long time friend of all of us since each of us got sober, spanning over 15 years. Timmy brings a wealth of knowledge, experience, faith, and good vibes as the three of us discuss a variety of topics surrounding life and recovery. From topics such as being married to a person not in recovery, to having a blended family, to navigating early sobriety in a halfway house, and dealing with life's issues in a faith-based way. This episode has a great flow and promises to be inspiring to all levels of recovery and also those not in recovery.Seek God first and He will be the one to determine if you need to seek human counsel. -Timmy Mac-Don't forget to like, share, rate, and download the podcast on all of your listening platforms. Check out and subscribe to our YouTube channel, @trudgrereportpod, for other content surrounding sports and trending topics. Trudge on good people. Contact the Guys:Instagram: @trudgereportpodFacebook: Trudge ReportTikTok: trudgereportpodYouTube: @trudgereportpod
Harsh Kumar joins Sanjay Dixit to decode NDTV's TRP rise, Ravish's Iran tilt, and the media's changing game. As Republic slips, NDTV surges with new anchors and war coverage. Old faces lose relevance, but the propaganda finds new forms.
Send us a textThis week I'm up in Toronto talking with Jumble Face, Urban Ninja and TRP 613 before the opening of “Pasted”, Toronto's first wheat paste focused gallery show. We're discussing how the concept for the show came about and what they are hoping the outcome will be for the street art scene in Toronto and the surrounding area.
Send us a textKaren Read found not guilty on 2nd degree murder and leaving the scene of an accident! She was found guilty of misdemeanor operating under the influence (of alcohol). The jury was attentive and asked several questions of the judge, they were dialed in, really couldn't ask for more.The jurors are taking media interviews and there are some commonalities- Trp. Bukenik came off as arrogant and petulant. The damage to John's arm, simply did not align with a car strike. Hank Brennan's objections were a problem for the jury. There is a whole lot more, don't miss this episode!Will any take notice of this judge in Norfolk County? is she a problem or no? Email me to discuss!!Alan Jackson on theHowie Carr Show-https://bit.ly/4nfB3j0Brian Albert et al interview-https://bit.ly/4efUgNdMicheal Proctor interview-WCVB TVhttps://bit.ly/3GaFoTMX-bcpbeantown Email-barry@bostonconfidential.net
TRP's new Vistar drivetrain combines a 12-speed cassette with a Classified internally geared hub to give you the benefits of a front derailleur without the hassle and complication, but does it work in the real world? Senior Tech Editor Josh Ross has spent months using it and explains the benefits, drawbacks, and how the hybrid 1X system compares to a traditional drivetrain. Josh has also been riding the new SRAM Force and Rival drivetrains that aim to bring the performance of Red down to a lower price point; he describes the differences between each group and tells Levy why Force is the answer. Cervelo also just released their Aspero-5 gravel race bike that trades tire clearance and comfort for pure aero-focused speed, which is the opposite approach that we're seeing with most new designs. Alvin has been testing the fresh Aspero and explains why this new "gravel bike" might be the ideal all-road machine for many riders. Lastly, the crew debates the UCI's strange new tech mandates that limit handlebar width, fork leg geometry, rim height, and aero helmets, all of which are intended to slow racers down and increase safety. But are yet more rules really the answer, and how do the UCI's decisions affect what consumers can purchase? For your consideration: TRP Vistar with Classified Stacks up to the Big Groupset Players, but There's a Catch SRAM Force AXS First Ride: RED Gets a Discount SRAM Rival AXS XPLR First Ride: 13-Speed Gets Cheaper First Ride: Cervelo Áspero-5 Is a Fast Gravel Bike That Might Just Replace Your Road Bike New UCI Gear Rules Incoming: Rim Height Limits, Minimum Bar Widths, and a Tech Fraud Crackdown
Your best new clients might already be sitting in front of you. Are you asking the right questions to bring them in?Dr. Lona sits down with Dr. Chris Grier, a seasoned TRP coach and experienced practitioner, to explore how internal marketing can quietly become your most powerful growth tool. Instead of hoping for word-of-mouth, they walk through how to build processes that consistently turn trust into new business. From first calls to new patient visits, every step can become an opportunity to plant seeds that later grow into referrals. If you're looking to scale without shouting louder online, this is a refreshingly practical approach.Key Highlights02:05 - Learn how to shift from passive referrals to a reliable system that grows your business from within.03:16 - Understand the three types of internal referrals and when to use each to maximize results.05:10 - Discover how early conversations can be designed to plant referral seeds right from the first call.06:32 - Understand the difference between hunting and farming when it comes to marketing. 08:09 - Learn the best timing to ask for referrals and why early enthusiasm is your biggest advantage.09:00 - Get practical ideas for turning early care experiences into natural, low-pressure referral moments.09:29 - Understand how to build a referral culture that includes your whole team, not just one provider.12:27 - See how internal education can spark action when clients realize someone they love needs help.15:20 - Learn how to help clients connect the dots between their concerns and the solutions you offer.17:50 - Discover why consistency matters and how repeated asks can eventually lead to life-changing results.20:23 - Dr. Sebastian welcomes Success Partner, Dr. Tabor Smith of Spinal Hygiene to explore how spinal hygiene boosts patient engagement and long-term retention in chiropractic care. Dr. Tabor shares his journey in transforming patient education, leading to the spinal hygiene movement. Learn key strategies like the Better Results Faster workshop and the 21-day Spinal Hygiene Challenge to improve patient commitment and outcomes. Resources MentionedRegister Now for the TRP Conversion & Retention Immersion - June 27 & 28, 2025 in Sydney, AUS - https://theremarkablepractice.com/upcoming-events/ For more information about Spinal Hygiene please visit: https://www.spinalhygieneproducts.comTo schedule a Strategy Session with Dr Lona: https://go.oncehub.com/DrLonaBuildPodcastTo schedule a Strategy Session with Dr Bobby: https://go.oncehub.com/DrBobbyBuildPodcastFollow Dr Bobby on Instagram: https://qr.me-qr.com/WOz1qy6E Follow Dr Lona on Instagram: https://qr.me-qr.com/o2oFbovyLearn what it takes to be Remarkable!: https://theremarkablepractice.com/
Esta semana nos hemos retrasado un poco en lanzar el podcast porque había dos novedades de las que teníamos que hablar sí o sí, los nuevos grupos Di2 de Shimano para MTB y la renovación de los Force y Rival de SRAM y la llegada de versiones XPLR para gravel. Pero es que, además, al final la semana ha quedado muy llena de novedades. Empezamos con el anuncio por parte de Shimano de dos nuevos grupos Di2 para MTB: el nuevo Deore XT M8200 y el Deore M6200, ambos electrónicos e inalámbricos que heredan las tecnologías que vimos hace poco en el XTR. En el artículo y el podcast te contamos todos los detalles y los precios. Para SRAM el 1x13 en gravel gana terreno con sus nuevas versiones XPLR de los grupos Force y Rival AXS, que además también heredan el diseño y tecnologías del tope de gama Red. Pero no terminamos ahí con las transmisiones, TRP ha presentado junto a Classified el Powershift, un grupo electrónico e inalámbrico que ofrece hasta 1x16 velocidades. Por su parte, Cervélo ha desvelado la nueva Áspero-5, una “Gravel Race” en toda regla que nos recuerda a la S-5 de carretera y que nace con una mejora de la aerodinámica impresionante (hasta 37 vatios más rápida), más ligera que la anterior, y con mayor integración de elementos. Como os decía, no contentos con esto, la semana ha estado cargada de actualidad, así que no tejamos de lado la llegada de Brembo al MTB de manos del equipo Specialized Gravity. O la última actualización del Fazua Ride 60 que, en realidad, puede no ser la que esperaban los usuarios de este sistema. Tampoco las nuevas ruedas “tope de gama” que Oquo ha presentado, la nueva mini bomba electríca Trek Air Rush, las novedades que nos ha presentado Schwalbe o los nuevos kits de mechas de X-Sauce para sellar agujeros que el Tubeless no puede. Por último, la UCI ha anunciado una nueva serie de medidas que afectan a las medidas (valga la redundancia) de los manillares, de la horquilla y los tirantes, perfiles de las ruedas, a los tipos de cascos... y lo analizamos bajo una perspectiva que seguramente te sorprenda. Enlaces de interés: Nuevos Shimano Deore XT Di2 y Deore Di2: https://www.mtbpro.es/actualidad/deore-xt-deore-di2 Nuevos SRAM Force y Rival: https://www.maillotmag.com/actualidad/nuevos-sram-force-y-rival-axs-con-versiones-xplr-1x13 Vistar Powershift de Tektro y Classified: https://www.maillotmag.com/actualidad/ya-disponible-vistar-powershift-el-grupo-electronico-e-inalambrico-1x16-fruto-de-la Cervélo Áspero-5: https://www.maillotmag.com/actualidad/nueva-cervelo-aspero-5-la-s5-del-gravel-race ¿Brembo entra al MTB?: https://www.mtbpro.es/actualidad/brembo-llega-al-mtb-de-la-mano-de-specialized-lo-veremos-en-tiendas Actualización Fazua Ride 60: https://www.mtbpro.es/actualidad/fazua-incorpora-el-kickoverrun-su-ride-60 Nuevas ruedas Oquo: https://www.maillotmag.com/actualidad/oquo-presenta-nuevas-ruedas-para-carretera-y-gravel-equipadas-con-el-buje-q10-de-diseno Trek Air Rush: https://www.maillotmag.com/actualidad/trek-air-rush-la-mini-bomba-electrica-que-equivale-cuatro-cartuchos-de-co2 Novedades de Schwalbe: https://www.maillotmag.com/actualidad/schwalbe-g-one-overland-pro-mas-proteccion-y-agarre-para-gravel y https://www.maillotmag.com/actualidad/schwalbe-aerothan-las-camaras-de-tpu-mas-ligeras-de-la-marca-ahora-con-valvula-de Cartuchos de mechas X-Sauce: https://www.mtbpro.es/actualidad/nuevos-cartuchos-de-mechas-x-sauce-para-tubeless-los-mas-compactos Nuevas medidas UCI: https://www.maillotmag.com/actualidad/la-uci-se-mete-de-nuevo-ancho-de-los-manillares-perfiles-de-las-ruedas
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The Trident Room Podcast (TRP) team is launching an all-new series delivering authentic conversation on current, topical issues. Each episode of TRP Unfiltered features a round table of podcast hosts, NPS students and their guests tackling a random question submitted by TRP listeners … Just the kind of stout conversation you'd expect from the Trident Room Podcast. Up first, what is the best (and worst) leadership advice you have ever received? ----------------- The Trident Room Podcast is brought to you by the Naval Postgraduate School Alumni Association and the Naval Postgraduate School Foundation. www.npsfoundation.org. For comments, suggestions, and critiques, please email us at TridentRoomPodcastHost@nps.edu, and find us online at https://www.nps.edu/tridentroompodcast. Thank you! Tags: NPS, Naval Postgraduate School, Monterey, California, Navy, Army, Marine Corps, Air Force, U.S., United States, Coast Guard, DOD, Military Education, Podcast, Military Podcast, The Trident Room, The Trident Room Podcast The views expressed in this podcast are those of the individuals and do not reflect the official policy or position of the U.S. government, the Department of Defense, the U.S. Navy, or the Naval Postgraduate School.
Another amapiano mix is here! Once again crafted with love and focusing on a more subtle sound, this mix continues the sound established in the previous mix with a bit more variations throughout the mix. Hope y'all like it. Enjoy! 1. Djy Vino & Nkulee501 - Jappino [Piano Hub] 2. Lady Du - uZuma Yi Star [Wa Wa/EMEXTEE] 3. Djy Lipton - Kwa Dembele [Atlehang Recording Studio] 4. Djy Lipton, Simlet Vocalist - Uvalo [Atlehang Recording Studio] 5. Pele Pele, Msaro, Saptharr Lomjitarr - My Darlie [Pop_Up Inc.] 6. Nation Deep, Gubziin - Yebo Bafethu [Gubzin] 7. Felo Le Tee, MDU aka TRP, Scotts Maphuma, Nkulee501, Soulful Disciple - Amazekethe [New Money Gang Records] 8. Jauza814, Djy Kp - Hello [Rapture Music Group] 9. Lady Du, Vigro Deep, Murumba Pitch - Asijabule [Rinse] 10. Sayfar, Scotts Maphuma, Cyfred, BenyRic, Tango Supreme, Cowboii - Thandi Mali [Cyfred Holdings] 11. Felo Le Tee, Vyno Miller, Myztro - 99 [New Money Gang Records] 12. Nizhe DeSoul - Shakes & Les [Underground Vessel Records] 13. Thabz Le Madonga, CaltonicSA, Yano Masters - Wamutlwareng (feat. Groot Man feat. Bog Man) [Ejarden Entertainment] 14. Linda Moeketsi, Ntwana_R - Papta Dubane [Thaha Music] 15. Kamokay99, Terry SA5 - RedBull [PRDS Direct] 16. Mfr Souls, DJ Maphorisa, Chley, Thuto The Human - Azishe [Kombelani] 17. 031Choppa, Ice Beats Slide, 2Kultured, Shakes & Les - YELA [031Choppa] 18. Almighty, Lady Du, Busta 929, Scotts Maphuma, Djy Biza, Ntokozo Vocals - Come On Lets Dance [Umsebenzi Wethu Records] 19. Scotts Maphuma, Mellow & Sleazy, Dooushii - MaDlamini [Session 55 (Pyt) LTD] 20. Djy Bakziin - Boyz Holiday (feat. Scotty kiddow & Maverse) [Djy Bakziin] 21. Terminator Under Score - Koze Kuse (Revist) [Terminator Under Score]
In this episode of the BikeRadar Podcast, digital editor Jack Luke grills Simon von Bromley on his experience with Vistar – an all-new drivetrain that neatly integrates Classified's two-speed hub into a fresh component ecosystem from TRP. The pair are joined by MBUK presenter Tom Marvin, who gives his take on the system, having tested Classified for BikeRadar on his gravel bike. https://www.bikeradar.com/news/official-tour-de-france-guide https://www.bikeradar.com/reviews/components/groupsets/groupset-road/trp-classified-vistar-powershift-groupset-review https://www.bikeradar.com/news/shimano-kills-di2-batteries-with-self-powered-qauto-hub Learn more about your ad choices. Visit podcastchoices.com/adchoices
The Classified Powershift Hub, with its internal gearing that makes a 1x chainring work like a 2x, has always been a point of curiosity around the Lab. However, without a full groupset to give the shifting a proper home, there has always been hesitation. That is, until Logan got his hands on the brand new collaboration between the Belgian company and the brake specialists at TRP for a full review at Cycling Weekly. From that testing, it was clear we needed to delve into it here. In this episode, Logan ceded the hosting chair to Stephen Fitzgerald, our Intern/CEO, and we brought Drew Van Kampen, our resident Always Trying New Things Guy, to pepper Logan with questions around the new groupset and explore a few tangents along the way. Host: Stephen Fitzgerald Guests: Drew Van Kampen and Logan Jones-WilkinsProducer: Logan Jones-Wilkins Hosted on Acast. See acast.com/privacy for more information.
Výživový specialista Petr Havlíček mluví otevřeně o refluxu – co ho způsobuje, proč je tak častý a co s ním dělat. Vysvětlí rozdíl mezi pyrózou a refluxem, jak upravit stravu, kdy jsou potřeba léky a jaké doplňky stravy mohou pomoci. Dozvíte se i to, proč trpí refluxem sportovci, těhotné ženy a lidé, kteří si problému často ani nevšimnou.0:00 Úvod - Reflux0:55 Je reflux častý problém? Jaký je rozdíl mezi pyrózou a refluxem?1:40 Co způsobí, že mám reflux? 3:35 Dá se reflux vyléčit? Co doporučují lékaři a odborníci? 6:35 Jaká jsou režimová opatření ohledně stravy.13:00 Trpí kulturisté na reflux? Co je jejich spouštěč? 15:00 Klasické spouštěče pálené žáhy. 15:50 Pálení žáhy během těhotenství. 16:40 Lidé nevnímají, že mají reflux. Skryté příznaky.18:00 Co když mi diagnostikují reflux? 21:00 Jak poznám, kdy se mám najíst? Přerušovaný půst s refluxem? 23:00 Je třeba užívat léky na reflux? 24:30 Dá se předcházet refluxu, pokud ho máme dědičný? 25:40 Můžu si za spuštění refluxu sám? 29:00 Lidé se o seba málo zajímají. 30:20 Jaká jsou celková režimová opatření? 31:07 Jak správně jíst? 34:30 Jak se chovat po jídle? 36:00 Pořád existují závodní restaurace? 39:21 Jaké zařadit doplňky stravy a jak se sebou pracovat? 41:50 Proč mít dobré přátelé?
1 Peter 5:71. Mdu aka trp Thatohatsi Tracy2. Kelvin Momo - Suit & Tie (feat. Jinger Stone & Nvcho)3. Bandros & Warren Justin - Space (feat. Jinger Stone)4. DJ Moscow, Brandon Dhludhlu, Cnethemba Gonelo - Ungangilimazi ft Frank Mabeat5. DJ Fresh SA, Nkatha, B33KAY SA - Stay Real (Amapiano Remake ft Phemelo Saxer)6. Soa Mattrix - Moya Wami (feat. Bassie & Happy Jazzman)7. Czwe De Ancestral Ft Thatohatsi, Small Keys - Nkosazana8. Kuya Phileka9. Gaba Cannal & Artwork Sounds - My Blessing10. Kelvin Momo & Boohle - Bazali (feat. Mick Man)11. Babalwa M & Kelvin Momo - Dlala Ngothando (feat. Mawhoo)12. DJ Maphorisa & Xduppy - Feel A way (feat. Nanette)13. MaakZen, Bayeza ft Mono-T Yves14. Doza Nation, Tman Xpress & Abidoza - Sthandwa Sami15. MFR Souls, Mdu aka TRP & Kabza De Small - Saxo (feat. KJM-Cornetist)16. Soa Family - The Mattrix ft Soa Mattrix, DeSoul17. Tycoon, MDU aka TRP & Anchorbee DJ SA - Steel Drum18. Bandros, Stixx & Nobantu Vilakazi - The Massai19. Stixx & DBN Gogo - Buya (feat. Nvcho, Nia Pearl, Madlamini & S.O.N)20. Mdu aka TRP - Deep 3
Welcome, Beautiful Soul
Hnutí ANO je sice hlavním favoritem sněmovních voleb, ale Andrej Babiš má oprávněný dojem, že volební kampaň i preference stagnují. Čtyři měsíce před volbami proto vyměnil hlavního manažera kampaně Jana Richtera za podnikatele Jakuba Střeštíka.Co ANO škodí a co je limituje? Babiš těžce nese skandály ústecké organizace ANO, která se v řadě míst chová jako mafie na dobytém území. Rovněž mu škodí zahraničněpolitické spojenectví s premiérem Ficem, Orbánem a prezidentem Trumpem. Trpí tím hlavně jeho středoví, váhaví voliči, takže Babiš doporučuje jedno: dělat předvolební veselice s lidmi a nemluvit o zahraniční politice.Babiš také ustupuje od konzervativního nátěru, který si před časem pro ANO pořídil. Jednak tomu jeho voliči příliš nerozumějí a současně se uvnitř evropské frakce Patrioti pro Evropu příliš umazal od stran, které dělají proputinovskou politiku, což jeho nevyhranění voliči nenesou dobře.Vytáhl proto ekonomická témata a na billboardech srovnává ceny výrobků před covidem a dnes. Podle údajů Světové banky jsou však ve světě oproti roku 2019 potraviny obecně dražší o 27 procent a zemědělské komodity dokonce o 40 procent.To Tomio Okamura jde ještě dál – na svých mítincích nabízí pivo, ovoce a zeleninu, jejichž ceny se přibližují těm před 45 lety!To Filip Turek z Motoristů má úplně jiné starosti. Jeho svět chlapeckých snů a fikcí, který ztvárnil ve své autobiografii, rozmetala dvojice analytiků Mahdalová–Škod, když doložili, že jeho úspěchy „formulového jezdce“ jsou jedna velká lež.Vzpamatují se Motoristé z téhle rány?
Trpělivost jako jedno z ovoce Ducha Svatého, je inspirovaná slitováním, neodsuzuje, odpouští a je důkazem přítomnosti a moci svatého Boha. U Modliteb podle Bible na téma "trpělivost z Ducha svatého" vás uvítá Dana Kenningová.
Welcome, Beautiful Soul
Healing souls through music1. Mdu aka Trp x Tycoon - Untitled (Feat. Thatohatsi & Tracy)2. Kelvin Momo & Da Muziqal Chef - Bo Gogo (feat. Tracy & Thatohatsi)3. MDU aka TRP - Sabela (feat. Tracy & Thatohatsi)4. Tycoon, Toby Franco & Thabza Tee - Mhlobo Wami (feat. Tracy & Thatohatsi)5. Babalwa_M_-_Ungazilibali6. Kabza De Small and DJ Maphorisa ft Mashudu, LeandraVert, Chronical Deep - Yiyo7. Mlindo The Vocalist & DJ Maphorisa - Umdali (feat. Tman Xpress & Phila Dlozi)8. Mashudu - Kwazulu (feat. Murumba Pitch & Soa Mattrix)9. Gaba Cannal & Oscar Mbo - Lord Is My Light (feat. The Bless)10. Josiah De Disciple - Son Of Ingress11. MFR Souls - Iskathi (feat. Maline Aura, Bassie & Shane907)12. Soa Mattrix - Iskhathi (feat. Bassie, Happy Jazzman & Faith Strings)13. Kelvin Momo - Intyatyambo (feat. Babalwa M & Yallunder)14. Russell Zuma, Nova MusiQ & George Lesley - Siyathandana (feat. Zain SA, Gaba Cannal & Jay Sax)15. Kelvin Momo - Uku Khanya ft Stixx, Yallunder, Umthakathi Kush16. Mashudu - Shlobo Sam (feat. ilovelethu)17. Mordecai & Katlego Vocals - Inhliziyo18. ARAK ZA & DaVinci's Disciples - Survived19. Sha Sha, Kelvin Momo & Sykes - Ndawana20. T-Man SA & MacG - The Mummy21. Chronical Deep,Latique & Kabza De Small - Hayi Baba feat. Leehleza & Ezra22. Novatron, Mellow & Sleazy & DJ 787 - Kshubile (feat. Scotts Maphuma & GoodGuy Styles)23. Soa Family - Lesilo ft Frank Mabeat, Tribal Soul, Soa-Mattrix
*This episode is available AD-FREE on both of our patreon channels*It's been a frenzy of a week, so we were pleasantly surprised to find this episode of World's Strictest Parents didn't turn out to be a lesson in the demise of society; in fact, it shone a light on two gay dads who apparantly wrote the book on how to talk to your kids and how to make sure they don't turn into a-holes! Of course, we should have known it was going to be a banger if a request, bc it was made by TRP submission VIP: Daniel Welling, a real life foster dad! After we wrap up the episode recap, Daniel joins us to discuss the foster care system and we were fascinated to hear his stories! It's lovely to hear some positive examples of foster parents, since it seems only the bad ones get media attention! May is Foster Care month, and we couldn't be happier to spend this first week with one of our fave listeners! Enjoy!!!https://www.childcrisisaz.org/LEAVE US A VOICEMAIL AND SHARE YOUR THOUGHTS!Snark and sarcasm is highly encouraged as we see what our favorite family is up to, as well as a dip into the latest pop culture news and highlights. Subscribe on YouTube, Patreon, and your favorite podcast app!Please like and subscribe on Youtube!Join our private Facebook Group "We Love to Hate Everything"Coming up this week on Patreon:*THE ENTIRE BACKLOG OF AMANDA LOVES TO HATE TEEN MOM IS AVAILABLE FOR only $3*WE LOVE TO HATE TV*Tier 1+: World's Strictest Parents UK: New Jersey Family (with special guest and foster parent, Daniel)*Tiers 2+: Sister Wives S13 E4 "Kody's Shocking Move" (part 2)TOTAL REQUEST PODCAST World's Strictest Parents UK: New Jersey Family (with special guest and foster parent, Daniel)GIRL DINNERGirl Dinner Episode 42: "Polyfamily Pilot"Like & Subscribe! Hosted on Acast. See acast.com/privacy for more information.
The new Amapiano mix is here! Once again crafted with love and focusing on a more subtle sound, this mix features a beautiful tempered groove throughout. Hope y'all like it. Enjoy! 1. Kabza De Small, Mfr Souls, MDU aka TRP, KJM-Cornetist - Saxo [Kombelani] 2. Kabza De Small, Stakev - Bayafowna [Piano Hub] 3. Stakev - Kosha Rekere [Piano Hub] 4. DJ Maphorisa, Mellow & Sleazy, Kabelo Sings, Xduppy, Seun1401 - Ke System [New Money Gang Records] 5. DBN Gogo, Chley, Zee Nxumalo, Ceeka RSA, Shakes & Les - Funk 55 feat. Ceeka RSA feat. Chley [Kreativekornerr] 6. LeeMcKrazy, Shakes & Les - Funk 99 [Kreativekornerr] 7. Visca, Young Stunna, Scooby Steeze, ShaunMusiQ & Ftears, FREE THE YOUTH - HELLO (INDABA) [LVRN Records (Love Renaissance)] 8. Tango Supreme, Warren Justin - Club 88 [LVRN Records (Love Renaissance)] 9. DJ Maphorisa, Tyler ICU, Tumelo.za, Nandipha808, Ceeka RSA, Tyron Dee - Mnike [New Money Gang Records] 10. Tycoon, Warren Justin, El.Stephano, Mlawra SA - Amateki (feat. Warren Justin) [Noto Solutions] 11. Tyler ICU, Masterpiece YVK, Al xapo, Ceeka RSA - Mlume Bhobbi [Piano Hub] 12. DJ Maphorisa, Scotts Maphuma, LeeMcKrazy, TNK MusiQ, LastbornDiroba, Xduppy - Abo Nokuthula Revisit [New Money Gang Records] 13. SLY, Kabza De Small, Young Stunna, Dench, Masterpiece YVK - Desha [Piano Hub] 14. TDK Macassette, Tycoon, Mashudu, Springle, Fanarito - Mali Ekseni (feat. Mashudu, Springle & TDK Macassette) [Tyza Wav.] 15. SLY, Kabza De Small, Tycoon, Dladla Mshunqisi, Goldmax - Iza Mawala (feat. Dladla Mshunqisi & Goldmax) [Tyza Wav.] 16. Mfr Souls, Olley RSA - Yaphela Imali [Kombelani] 17. Kelvin Momo, Jinger Stone, Nvcho - Suit & Tie (feat. Jinger Stone & Nvcho) [Kelvin Momo Productions] 18. Tracy, Kelvin Momo, Da Muziqal Chef, Thatohatsi - Bo Gogo (feat. Tracy & Thatohatsi) [Kelvin Momo Productions] 19. Mfr Souls, Shane907, Tonic Blue, Dot Mega - Roots [Kombelani]
Tracklist 01. Gaba Cannal - Serenade 02. Kelvin Momo, Babalwa M, Yallunder - Intyatyambo 03. Gaba Cannal, Meez, The Bless - Umasithela 04. Kelvin Momo, Da Muziqal Chef, Tracy, Thatohatsi - Bo Gogo 05. DJ Maphorisa, Xduppy, Sly, Tracy, Thatohatsi - Ukuphumula 06. Tycoon, MDU aka TRP, ANCHORBEE DJ SA - Steel Drum 07. DJ Maphorisa, Xduppy, Kabza De Small, Young Stunna, Thatohatsi, Nkosazana Daughter - Abantwana Bakho 08. Yumbs, Mashudu, Makhanj, Nia Pearl, Teddy Moloi, Zani - Awuboni 09. Zee Nxumalo, TBO, PYY Log drum King, DJ Tearz, Dr Thulz - Ngisakuthanda 10.Stakev, B33kay SA - Imali 11. Ntokzin, Josiah De Disciple, Zee_nhle, Starr Healer - Ex Yami Iyajola 12. Murumba Pitch, Kabza De Small, Young Stunna, Mthunzi - Qoma 13. Gaba Cannal, Oscar Mbo, The Bless - Lord Is My light 14. Mellow & Sleazy, Tman Xpress, CowBoii - Welele 15. Djy Vino, Nkulee 501 - Cool Affair 16. Mellow & Sleazy, Tman Xpress, LastBornDiroba, CowBoii, TheBuu - Ibhanoyi 17. DJ Stoks, Mel Muziq, Happy Jazzman, Bassie, Faith Strings - Mamazala 18. Murumba Pitch, Kelvin Momo - Hello 19. DJ Maphorisa, Xduppy, Enny M The Guitar, Focallistic - Dlala Ka Yona 20. Mellow & Sleazy, Tman Xpress, LowBass Djy - Mela Kufe Bani BPM:112 Size: 307mb Duration:02:12:41s For Bookings: email: keorapetseeightyfive@gmail.com OR WhatsApp +27 (81) 881 2063
Hynek Vich je enolog, znalec a milovník vína. Žil v Belgii, v Bordeaux pěstuje víno a radí francouzským producentům vína. Byl jsem na několika degustacích, kde hovořil o víně, a zjistil jsem, že je vědec, milovník a doslova básník vína. Proto jsem moc rád, že jsme se dohodli na společném natáčení. Užijte si – a bacha, následující povídání může vyvolávat velkou chuť na sklenku něčeho fakt dobrého..!00:00 Fascinace vínem a čtení jeho poezie.11:28 Párování s pokrmem.13:58 Jak vstoupit do dialogu s vínem?21:38 Jaká má být teplota vína?25:18 První přivonění a ochutnání.Zbytek rozhovoru, který najdete na https://herohero.co/petrhorky obsahuje navíc tyto kapitoly:33:45 Cíl každého vinaře je harmonie.38:09 Výroba i skladování vína musí být přesné.44:18 Každé víno má příběh, kulturu a vhodnou situaci.48:47 Trpělivost má cenu.51:23 Dobré víno nemusí být drahé.Kamera: Ondřej HošekStřih: Šimon RychlikSupport the show
We are excited to have Lindsay Leahy joining us for the second part of a two-part series. In Part 1, Lindsay shared her story, highlighting the importance of quieting the noise in our lives. Today, in Part 2, she dives into why establishing core values is essential, encouraging us to embody them and bring them into the world. She will also get you to consider what a good life would look like and how to make it happen. For those listeners who have not done so yet, please listen to part one first. Examples of core values: Integrity Honesty Faith Family Respect Commitment Kindness Time & Energy Prioritization Personal Growth Lindsay Leahy's Bio: Lindsay Leahy is a proud wife, daughter, auntie, and friend. She is passionate about Jesus, hugs, dreams, adventures, and deep conversation. She is the creator of the blog Grit, Gratitude, and Grace and the author of Take it All Apart: How to Live, Lead, and Work with Intention. Lindsay is also the founder and Dream Builder at The Restoration Project, a women-owned coaching and consulting practice that invites people to "look deeper to go higher." They hold space for leaders and teams to explore who they are at their best and how they bring that into the world. They have supported hundreds of amazing humans to improve their organizational health, team, leadership effectiveness, and individual well-being. In this episode: How Lindsay helps her clients find their core values Lindsay expands on the concept of quieting the noise Why you need to identify and reduce distractions Practical tips for creating quiet time daily to foster reflection and intention How personal and professional development tie together The benefit of improving your emotional vocabulary and how you can do that What teams can focus on to create a more enjoyable experience and maximize their effectiveness Links and Resources: Sinus Support Use code ENERGY to get 10% off MITOCHONDRIAL COMPLEX Use code OMEGA3S to get 10% off OMEGA3S Guest Social Media Links: The Restoration Project Take It All Apart (book) TRP on Facebook TRP on Instagram: @yourleadershipcoaches TRP on LinkedIn Grit, Gratitude, and Grace Follow Your Longevity Blueprint On Instagram| Facebook| Twitter| YouTube | LinkedIn Get your copy of the Your Longevity Blueprint book and claim your bonuses here Find Dr. Stephanie Gray and Your Longevity Blueprint online Follow Dr. Stephanie Gray On Facebook| Instagram| Youtube Twitter | LinkedIn Integrative Health and Hormone Clinic Podcast production by Team Podcast
This interview with Texas State House Republican Candidate Jon Schober from 30 December 2020 in Texas was a real hoot. Cross-posted on the Coffee with Jon podcast. Enjoy ! We had Jon on TRP podcast in 2022, where we spoke at length again about his Texas State House candidacy (4 August 2022 published here). Follow Jon Schober on Facebook at https://www.facebook.com/Schober4Texas if you like what you see and hear. Donate a gift to keep the podcast going on Venmo at-sign no space TheRepublicanProfessor or https://buymeacoffee.com/lucasj.mather Warmly, Lucas J. Mather, Ph.D. The Republican Professor Podcast The Republican Professor Newsletter on Substack https://therepublicanprofessor.substack.com/ https://www.therepublicanprofessor.com/podcast/ https://www.therepublicanprofessor.com/articles/ YouTube channel: https://www.youtube.com/@TheRepublicanProfessor Facebook: https://www.facebook.com/TheRepublicanProfessor Twitter: @RepublicanProf Instagram: @the_republican_professor
Sustainable success isn't about going faster—it's about building a business that supports your life, not the other way around.Dr. Lona sits down with Dr. Devin Vrana to discuss the seasons of growth, the importance of pacing yourself, and knowing when to shift gears in business and life. Dr. Devin shares her journey from high-volume, fast-paced solo practice to creating a business model that allowed for balance, family, and long-term fulfillment. They discuss how to avoid burnout, the power of mentorship, and how to align your practice with your personal vision for success.Key Highlights01:07 – Introduction of Dr. Devin Vrana and how she became a new coach in TRP, bringing energy and leadership to the community.03:14 – The danger of running too fast in business, how high-speed growth can become unsustainable, and lessons from early practice years.04:40 – A personal story about returning to practice too soon after childbirth, and the physical, emotional, and professional toll it took.06:37 – A life-changing moment—how her son's serious injury forced her to rethink her business model and create a more sustainable structure.07:42 – Why one-doc, high-speed, high-volume models aren't always the best long-term approach, and how different practice models can create freedom and longevity.09:22 – The power of mentorship and evolving beyond initial coaching frameworks to create a practice that truly aligns with your vision.12:39 – Why anchoring yourself in purpose (rather than outside expectations) is key to long-term fulfillment and sustainable success.14:03 – How the business world is shifting, and why modern practices need resilience, adaptability, and systems that work beyond just the owner.16:46 – The biggest mistake entrepreneurs make: following other people's definitions of success instead of creating their own.21:16 - Dr. Eric DiMartino and Justin Maxwell from Success Partner, Big Life Financial discuss transforming high income into generational wealth. Uncover how Big Life Financial supports chiropractors in optimizing their finances through strategic systems. They introduce the concept of ROE (return on emotion) alongside ROI, focusing on the peace of mind for business owners. Tune in to enhance your financial health and business success. Resources MentionedFor more information about Big Life Financial please visit: https://biglifefinancial.comTo schedule a Strategy Session with Dr Lona: https://go.oncehub.com/DrLonaBuildPodcastTo schedule a Strategy Session with Dr Bobby: https://go.oncehub.com/DrBobbyBuildPodcastFollow Dr Bobby on Instagram: https://qr.me-qr.com/WOz1qy6E Follow Dr Lona on Instagram: https://qr.me-qr.com/o2oFbovyLearn what it takes to be Remarkable!: https://theremarkablepractice.com/
We are excited to have Lindsay Leahy, the founder of the Restoration Project and author of the book Take It All Apart, joining us for a two-part series to help us build awareness and find the peace we are searching for in this chaotic world. Today, in Part 1, Lindsay shares how the Restoration Project came about and starts taking us through the importance of quieting the noise in our lives, connecting with our strengths, intentions, and dreams, and moving beyond our fears and limiting beliefs. Six ways to quiet the noise in your life: Start the day with five minutes of intentional quiet time to set the tone for a calmer, more mindful day Recognize the distractions that affect you most (social media, constant background noise, or unhealthy influences) Set boundaries on screen time and be intentional about the content you engage with Reduce background noise by turning off the TV or radio to allow space for silence and stillness Limit your exposure to those who do not support your well-being Turn off the radio or podcasts while driving occasionally to give your mind space to process and reflect Lindsay Leahy's Bio: Lindsay Leahy is a proud wife, daughter, auntie, and friend. She is passionate about Jesus, hugs, dreams, adventures, and deep conversation. She is the creator of the blog Grit, Gratitude, and Grace and the author of Take it All Apart: How to Live, Lead, and Work with Intention. Lindsay is also the founder and Dream Builder at The Restoration Project, a women-owned coaching and consulting practice that invites people to "look deeper to go higher." They hold space for leaders and teams to explore who they are at their best and how they bring that into the world. They have supported hundreds of amazing humans to improve their organizational health, team, leadership effectiveness, and individual well-being. In this episode: How everything changed for Lindsay when she started looking at herself through the eyes of God The benefits of coaching for health and longevity Lindsay gives an overview of her team and the services they offer at the Restoration Project What it means to quiet the noise in our lives How continuous self-reflection and adjustment help us stay true to our core values How quiet time in the morning sets the tone for the rest of the day How to connect with your strengths, intentions, and dreams Links and Resources: Use code MOOD to get 10% off 5HTP Use code CALM to get 10% off ADRENAL CALM Use code MAGNESIUM to get 10% off MAGNESIUM Guest Social Media Links: The Restoration Project Take It All Apart (book) TRP on Facebook TRP on Instagram: @yourleadershipcoaches TRP on LinkedIn Grit, Gratitude, and Grace Follow Your Longevity Blueprint On Instagram| Facebook| Twitter| YouTube | LinkedIn Get your copy of the Your Longevity Blueprint book and claim your bonuses here Find Dr. Stephanie Gray and Your Longevity Blueprint online Follow Dr. Stephanie Gray On Facebook| Instagram| Youtube | Twitter | LinkedIn Integrative Health and Hormone Clinic Podcast production by Team Podcast
Double Tap Episode 403 This episode of Double Tap is brought to you by: Brownells, Gideon Optics, Blue Alpha, Medical Gear Outfitters, Mitchell Defense, and Matador Arms Welcome to Double Tap, episode 403! Your hosts tonight are Jeremy Pozderac, Aaron Krieger, Nick Lynch, and me Shawn Herrin, welcome to the show! Double Tap- Need more questions. WLS- Need more reviews. - Dear WLS My dad hit my mom so I the family dog and now I have a hard time talking to women S. - Do you guys have a go to cleaning kit? Or do you just buy pieces and make your own kit? What are those pieces? I've bought several kits but they never seem to be ideal for cleaning any particular gun. Ice Wallocum - Could 50 clones of Savage defeat Nick, Jeremy, Shawn, and Aaron? The only weapons available to the guys are a frying pan, a set of brass knuckles, a fire extinguisher and a large flat-head screwdriver. Each clone is butt-ass naked. Try to not get a boner. No notes. Jakey Poo - I'm getting the itch... not like yours, Aaron. I need to add something to my gun collection. My current selection is as follows. A 223 AR A 223 AK A semi auto 12 gauge (yes Turkish, shut up) A 9mm AK A 45 1911 A full size 9mm canik. A 9mm p365 xmacro. An m&p 22 handgun. A 22 heritage rough rider. So, where should I start looking and or saving next? I like the idea of a 45 pcc. I like the idea of a lever action. I like the idea of some other 22 to have for when my boys get old enough. I just don't know what to do. And don't say tons of ammo for all those things... that's already on the list. Thank you for all the feelings you give me every week, my fellow homeo sectionals. Alex W - Hi. Do you guys have slings on your home defense rifles? I had mine out last night due to sketchy shit going on outside my home and noticed the sling was all twisted up and wrapped around the stock. I think it would have still functioned fine but throwing the sling on might have been hard in a tense situation. How do you stow your slings to prevent that issue? Thanks. No notes. Savage Looks Like A Nutsack - I was at my local Scheels, and overheard a conversation about second focal plane scopes. The sales associate told the guy next to me that in a sfp scope, only the subtensions will be off if you use magnification. He explained that your center aimpoint on the scope will always be dead on no matter what, as long as the distance is ranged correctly. What's the associate right? I thought in all sfp scopes, your zero would be off on everything if you used the magnification. It doesn't make sense that the center point of the scope would always be correct under any magnification, but only the subtensions would be off. No notes Reese K - On the most recent This Week in Guns they talked about a blind man who bought a gun and then was complaining about how easy it was. If you guys became legally blind, from whatever terrible accident you want, what would you choose for home defense? Cory R - Why is Aaron such a douche. Dude is fucking up the show arguing about the dumbest shit. Arguing that ffls shouldn't be able to charge for transfers? Fucking dumbass. Then today argue with savage for not reading the facts right after he did. Jesus, please take his mic before I have to quit listening. DoppleBanger - Looking to buy a battle rifle clone from the 50s-60s era in .308. Price doesn't matter. What are your suggestions? M14 Clone? G3 clone? Fal? The winner of this week's swag pack is Ice Wallocum! To win your own, go to welikeshooting.com/dashboard and submit a question! Gun Industry News Springfield Launches 1911 TRP AOS: Optic Ready in 9mm Springfield Armory launched a new version of their TRP handgun, now available in 9mm along with the traditional .45 ACP. It features an Agency Optics System for red dot sights. There are eight models with options for 5” and 4.
Send us a textSupport the showBreakfast With Tiffany Show Official Facebook Page ~ https://www.facebook.com/breakfastwithtiffanyshow Tiffany's Instagram Account ~ https://www.instagram.com/tiffanyrossdaleofficial/ Breakfast With Tiffany Show Youtube Channel ~ https://bit.ly/3vIVzhE Breakfast With Tiffany Show Official Page ~ https://www.tiffanyrossdale.com/podcast For questions, requests, collaborations and comments, feel free to reach us via our e-mail ~ breakfastwithtiffanyshow@outlook.com SUBSCRIBE and SUPPORT us here ~ https://www.buzzsprout.com/1187534/supporters/new
Hey everyone, and welcome back to Dividend Talk! In this episode, we look into the latest market corrections and explore exciting stock opportunities. We chat about Intel's new CEO, the football matches that had us on the edge of our seats, and some fantastic dividend announcements from companies like Legal and General and Henkel. Plus, we answer your insightful questions on portfolio strategy, handling market volatility, and killer criteria for your holdings. Tickers Mentioned: INTC, V, O, SHEL, ASR, EPI, MSFT, EVVTY, SBUX, PEP, V, LGEN, SPX, MMM, RHM, JNJ, XOM, TGT, HD, WMT, GLB, CILA, TRP, GOOG, ASML, BA, MUM.
To, co se odehrálo mezi Donaldem Trumpem, jeho viceprezidentem J. D. Vancem a prezidentem Volodymyrem Zelenským 28. února v Oválné pracovně, bylo pozoruhodné nejen jako nediplomatický výlev, ale i jako názorná ukázka toho, jak Trump a jeho lidé vidí válku na Ukrajině. Trpí utkvělou představou, že Ukrajina válku prohrává a že jediným východiskem je ustoupit Putinovým požadavkům, píše nezávislý ruský novinář Alexej Kovaljov v článku pro server Foreign Policy.
To, co se odehrálo mezi Donaldem Trumpem, jeho viceprezidentem J. D. Vancem a prezidentem Volodymyrem Zelenským 28. února v Oválné pracovně, bylo pozoruhodné nejen jako nediplomatický výlev, ale i jako názorná ukázka toho, jak Trump a jeho lidé vidí válku na Ukrajině. Trpí utkvělou představou, že Ukrajina válku prohrává a že jediným východiskem je ustoupit Putinovým požadavkům, píše nezávislý ruský novinář Alexej Kovaljov v článku pro server Foreign Policy.Všechny díly podcastu Svět ve 20 minutách můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.
The City's Therapeutic Recreation Program is such a gem, and this conversation will explain why. February is Therapeutic Recreation Month and the perfect time to focus on how it impacts our entire community. The leader of TRP has provided recreational opportunities for children and adults with disabilities for 25 years, along with her team of exceptional employees and volunteers.
Balancing it all doesn't mean doing it all. This episode dives into the unique challenges and opportunities women face as leaders in their profession. Dr. Lona and Dr. Rachel Hovey share how to master adaptability, delegate effectively, and build systems that create more time and energy for what matters most. They discuss leveraging teamwork, setting boundaries, and finding support networks to thrive both personally and professionally. For anyone ready to embrace growth with grace and lead with intention, this conversation offers practical insights and inspiration.Key Highlights01:11 – Introduction of Dr. Rachel Hovey and the discussion of women's unique experiences in balancing family life and professional growth.02:49 – The creation of a space for women in TRP, addressing the nuances of practice ownership while managing life stages like pregnancy and maternity leave.04:27 – The value of building capacity over time by learning to leverage teams and resources to handle increasing responsibilities effectively.05:09 – Insights on delegating tasks and trusting a well-trained team to maintain work-life balance while scaling operations.06:40 – Embracing adaptability and finding joy in everyday tools and systems that reduce stress, both at work and at home.09:15 – Practical examples of leveraging resources like cleaning services and time-saving tools to focus on priorities and maintain productivity.12:14 – The importance of setting routines and non-negotiable boundaries to prioritize personal well-being and energy.15:45 – Advice for overwhelmed professionals on building systems, hiring the right people, and seeking guidance from experienced mentors.17:46 – Reflections on learning through challenges, leaning on support networks, and evolving from solo practice to team-driven success.20:47 – The shift toward collaborative, team-focused practices and the benefits of building community and camaraderie among women in the profession. Resources MentionedRegister Now for the TRP Remarkable Team Building Immersion - Feb 28 and Mar 1, 2025 in Brisbane, AUS - https://theremarkablepractice.com/upcoming-events/ To schedule a Strategy Session with Dr Lona: https://go.oncehub.com/DrLonaBuildPodcastTo schedule a Strategy Session with Dr Bobby: https://go.oncehub.com/DrBobbyBuildPodcastLearn what it takes to be Remarkable!: https://theremarkablepractice.com/Learn more about the Build Your Remarkable Practice: https://theremarkablepractice.com/build-your-remarkable-practice-podcast/Learn more about the Remarkable CEO Podcast: https://theremarkablepractice.com/podcast/Learn what it takes to be Remarkable!: https://theremarkablepractice.com/
Host Polly Swingle is joined by Gabrielle Tremp, MS, OTRL, and Dr. Elizabeth Osantowski, PT, DPT, CSRS, to discuss the latest evidence and research to treating individuals with upper extremity impairments following a stroke. Listen in to hear about what to expect following a stroke as it relates to the upper extremities, as well as the latest evidence-based practice to maximize recovery and function.Gabrielle Tremp, MS, OTRL, is a licensed Occupational Therapist with a Master's degree from Western Michigan University. With three years of experience in the field, she has spent the last 2.5 years at TRP, where she specializes in neurorehabilitation, including The Recovery Project's Concentrated Stroke Rehab Program. Gabrielle also works in acute care on the orthopedic and trauma unit. Outside of her OT role, she has a passion for dance and teaches both traditional and adaptive dance. Recently, she launched the "Together in Motion" adaptive dance class at The Recovery Project. Gabrielle is especially passionate about working with clients facing neurological challenges, particularly those with spinal cord injuries, stroke, and Parkinson's disease.Dr. Elizabeth Osantowski, PT, DPT, CSRS, is a dedicated physical therapist at The Recovery Project, specializing in neurological rehabilitation. She earned her Doctorate in Physical Therapy from Central Michigan University in 2021 and has since focused her career on treating neurological diseases and disorders. Elizabeth is a Certified Stroke Rehabilitation Specialist and an integral part of the Concentrated Stroke Rehab program at The Recovery Project. Additionally, she is a certified PWR! Moves Therapist. Since joining the team in 2023, Elizabeth has developed a strong passion for treating patients who have had a stroke and people with Parkinson's disease, continually advancing her expertise in these areas.Learn more about The Recovery Project! View our website at www.therecoveryproject.net Call us 855-877-1944 to become a patient Follow us on Instagram Like us on Facebook Thanks for listening!
In this episode, we explore where value might be hiding in today's high-valuation market. From overlooked oil and gas plays to global opportunities in Japanese railways and Chinese big tech, we break down areas of potential interest for savvy investors. We also discuss the pitfalls and potential in pharma, defense, and precious metal miners, as well as the challenges pandemic darlings face in a post-COVID world. Plus, Braden dives into the concept of quality in investing, inspired by Dev Kantesaria of Valley Forge Capital. Discover why the intersection of growth and predictability defines great companies and how this framework can help you identify enduring opportunities in any market environment. Tickers of Stocks/ETFs discussed: HAL, TVK.TO, CNQ.TO, TOU.TO, ENB.TO, TRP.TO, KMI, MPC, JNJ, PFE, MRK, LLY, NVO, KVUE,PPH, IHE, ZHU.TO, LMT, UNP, 9020, KWEB, BABA, FNV.TO, WPM.TO, ABX.TO, NGT.TO, GDX, GDXJ, ZGD.TO, DOO.TO, 7309 Check out our portfolio by going to Jointci.com Our Website Canadian Investor Podcast Network Twitter: @cdn_investing Simon’s twitter: @Fiat_Iceberg Braden’s twitter: @BradoCapital Dan’s Twitter: @stocktrades_ca Want to learn more about Real Estate Investing? Check out the Canadian Real Estate Investor Podcast! Apple Podcast - The Canadian Real Estate Investor Spotify - The Canadian Real Estate Investor Web player - The Canadian Real Estate Investor Asset Allocation ETFs | BMO Global Asset Management Sign up for Finchat.io for free to get easy access to global stock coverage and powerful AI investing tools. Register for EQ Bank, the seamless digital banking experience with better rates and no nonsense.See omnystudio.com/listener for privacy information.
Deciding when and how to hire an associate can make or break the success of your practice, and Dr. Kevin Day brings his expertise to this crucial topic. This episode dives into the key factors chiropractors need to consider before expanding their team, from evaluating patient volume and practice capacity to financial readiness and team preparedness. Dr. Day shares actionable advice on setting a clear vision, managing expectations, and implementing airtight systems to ensure a seamless associate integration. With insights on training your team, creating strong meeting rhythms, and preparing patients for change, this conversation is a must for chiropractors ready to grow their practice sustainably and effectively.Key Highlights00:53 – Dr. Kevin Day introduces his journey from starting a practice without systems to implementing TRP strategies and transitioning to a team-driven model.03:02 – The advantages of hiring associates and the importance of understanding when the timing is right to bring one on.04:14 – Key metrics for determining readiness to hire an associate, emphasizing the 80% capacity threshold.06:20 – Importance of recognizing that an associate's capacity may differ from the owner's, requiring clear expectations and communication.08:25 – Breakdown of different associate types: entrepreneurs, business builders, and caregivers, and aligning them with the practice's vision.11:31 – Setting realistic expectations for the first associate, including financial planning and understanding their role in patient volume and practice growth.15:20 – Clarifying that an associate's success depends on attracting new patients rather than solely taking on existing patient overflow.17:32 – The need for a robust marketing and operational plan before onboarding an associate to ensure quicker profitability and practice alignment.22:06 – Training patients to trust multiple doctors through consistent communication, shared case management, and strategic introduction to associates.25:37 – Building airtight systems, meeting rhythms, and reporting metrics to ensure smooth team integration and maintain patient retention. Resources MentionedRegister Now for the TRP Remarkable Team Building Immersion - January 31 and Feb 1, 2025 in Tampa, FL and Feb 28 and Mar 1, 2025 in Brisbane, AUS - https://theremarkablepractice.com/upcoming-events/ To schedule a Strategy Session with Dr Lona: https://go.oncehub.com/DrLonaBuildPodcastTo schedule a Strategy Session with Dr Bobby: https://go.oncehub.com/DrBobbyBuildPodcastLearn what it takes to be Remarkable!: https://theremarkablepractice.com/Learn more about the Build Your Remarkable Practice: https://theremarkablepractice.com/build-your-remarkable-practice-podcast/Learn more about the Remarkable CEO Podcast: https://theremarkablepractice.com/podcast/Learn what it takes to be Remarkable!: https://theremarkablepractice.com/
This is not for the faint of heart. It's a deep dive into Chevron deference doctrine starting with Judge Ruth Bader Ginsburg's DC Circuit opinion in 1982 against Anne Gorsuch, Neil Gorsuch's mother, who was at the time appointed by Republican Ronald Reagan to run the Environmental Protection Agency. We cover Ginsburg's 1982 decision here in Part 1. This sets us up for Part 2 of this deep dive where we will go through the famous Chevron USA v. Natural Resource Defense Council (1984), which reversed the Ginsburg opinion at the lower court. This in turn sets us up for Part 3, where we'll look closely at Loper Bright (2024), which in turn reversed the Republican win in 1984. This could be called Gorsuch v. Gorsuch, like Kramer v. Kramer but son v. Mother instead of spouses. Merry Christmas season to you from Trp. Luke, for TRP Donate on Venmo at-sign no space TheRepublicanProfessor
Piezo touch and pressure-sensing ion channels are showing up everywhere as the explanation for physiologic phenomena, both at the macro and micro levels. Ardem Patapoutian, my friend and colleague at Scripps Research, discovered these receptors back in 2010 and was awarded the Nobel Prize in 2021 for his work. As you'll see/hear from our conversation, the field has exploded. And you'll get to know Ardem, who is such a fun, charismatic, and down-to-earth person. He also recently got a unique tattoo (videos below) and I wonder (unlikely) if any other Nobel laureates have one related to their discovery?!Below is a video clip from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! The audios are also available on Apple and Spotify.Transcript with links to audioEric Topol (00:07):Well, hello. It's Eric Topol with Ground Truths, and I've really got a special guest today. The first time for the podcast, I've been able to interview a colleague and faculty at Scripps Research, Ardem Patapoutian, who just by the way happens to be the 2021 Nobel Laureate in Physiology or Medicine. So welcome, Ardem. It's so wonderful to have you.Ardem Patapoutian (00:30):Thanks so much, Eric. Looking forward to chatting with you.Eric Topol (00:34):Well, this has been interesting because although I've known you for several years, I didn't research you. I mean, I had to learn about more than I even do. And of course, one of the great sources of that is on the Nobel Prize website where you tell your whole story. It is quite a story and not to review all of it, but I wanted to go back just before you made the call to move to Los Angeles from Beirut, Lebanon and with the scare that you went through at that time, it seemed like that was just extraordinary that you had to live through that.Ardem Patapoutian (01:11):Yeah, so I am of Armenian origin, but I was born in Lebanon and born in 1967, so I was eight years old when the civil war started. So it's a kind of bizarre childhood in the sense that with all the bombs and fighting in Lebanon. So it was tough childhood to have, but it was never personal. It was bombs and such. And so, the event you're talking about is, I happened to be kidnapped while crossing East to West Beirut. They only held me for four or five hours at first asking me questions to see who I am, but I think they pretty soon figured out that I was not a dangerous guy and they ended up letting me go. But before that, that incident really had a huge impact on me so that by the time I got home, I literally said, I'm out of here. I'm going to find a way to leave the country. And so, that's what, very quickly within a few months I packed and came to United States.Eric Topol (02:19):And how did you pick LA to be your destination?Ardem Patapoutian (02:22):Being from the Armenian community, there's a lot of Armenians in Los Angeles. My cousins already had moved there. They also grew up in Lebanon. And my brother, who's a few years older than me, got admitted to USC graduate school in engineering. So he was going to be there. So it made a lot of sense.Eric Topol (02:44):Oh yeah.Ardem Patapoutian (02:45):Unlike him, I came with no school or job prospects because it happened so fast that I kind of just left. One year I was at American University of Beirut for one year, but then just left and came here. So worked for a year in various jobs and then started going back to school to UCLA.Eric Topol (03:07):Yeah, I saw how there was about a year where you were delivering pizzas and before you got into UCLA, and that must have been an interesting off year, if you will. Well, the story of course, just to fast forward, you did your baccalaureate at UCLA, your PhD at Caltech, postdoc at UCSF, and then you came to Scripps Research 24 years ago along with Pete Schultz, and it's been quite an amazing run that you've had. Now, before we get into PIEZO receptors, the background, maybe you could help me understand, the precursor work seems to be all related to the transient receptor potential (TRP) series, also ion channels. They were of course related to whether it was heat and temperature or somatosensory. How do these channels compare to the ones that you discovered years later?Background on these Ion ChannelsArdem Patapoutian (04:09):Yeah, so the somatosensory neurons that innervate your fingertips and everywhere else in your body, their main job is to sense temperature and pressure. And this is very different than any other neuron or any other cell. So when you touch a hot stove that's burning hot, you need to know about that immediately within milliseconds or something cold. So the opposite side of it is pressure sensing, and it also comes in light touch, which is pleasant or a hammer hitting your finger, which is unpleasant. But all of these have the same characteristic anyway, that is your body has learned at the molecular level to translate a physical stimulus such as temperature and pressure into an electrical signal that neurons use to communicate with each other. But this idea of how you translate physical stimuli into chemical or electrical signal has been a long open question because as you know, most of our cells communicate by chemicals, whether that's hormones or small molecules, we know how that works, receptor bind to ligand, confirmational change and you get a kinase activation and that's enough. But here, how do you sense pressure? How do you sense temperature? It was just, there wasn't much known about that. And that's why our earlier work on TRP channels, which were temperature sensors came before the pressure. And so, they're very related in that sense.Eric Topol (05:52):The structure of these, if you were to look at them, do they look pretty similar? What the TRP as you say, and what you did back in the 2010 Science paper, which we'll link to, of course the classic paper where you describe PIEZO1 and PIEZO2, but if you were to look at this structures, would they look pretty similar?Ardem Patapoutian (06:14):No, that's a good question. And they absolutely don't. That's why finding these receptors were so hard. So if you go back to other sensory receptors, vision rhodopsin G-protein coupled receptor (GPCRs), larger G-protein coupled receptor look the same. So for example, when it was identified by chemically, that smell also works through G-protein coupled receptor. Richard Axel and Linda Buck, who also won the Nobel Prize, found those receptors by homology to visual GPCRs. The ion channels other than the fact that they crossed the membrane a few times or more, they have nothing else in common. If you looked at their structure, you can't even immediately tell they're ion channels. So you couldn't find these by structural homology or sequence homology. So you had to do something else. And usually that means functional screens and et cetera.Eric Topol (07:09):Well, yeah, and I'm in touch with the screening. We'll get to that and how you dig these up and find them. But the somatosensory ones are really interesting because I don't think a lot of people realize that when you have wasabi or you have Listerine mouthwash and feel the burn and that these are all mediated through these channels, right?Ardem Patapoutian (07:35):Yeah. So there's this whole field of chemesthesis, which means senses in your mouth, for example, that are not explained by taste transduction and olfactory. And these are actually by the same somatosensory neurons that help you sense temperature and pressure. And some of these receptors are the same. Their evolution has taken over and used them for many different things. The prime example of this is the capsaicin receptor that David Julius my co-laureate identified, which is also heat receptors. So all languages describe chili peppers as hot, and that's not a coincidence. It actually activates heat activated channel, and that's why we think of it as hot. And so, the same goes to another one of these TRP channels that you mentioned, which is TRPA1, and this one is also activated, but a lot of spicy foods other than the chili pepper active ingredient includes what's in garlic and onions and everything that has this burning sensation and chemicals of this and wasabi and chemicals of this are used in over the counter products like Listerine that cause that burning sensation.Eric Topol (08:54):So when you're chopping onions and it makes you cry, is that all part of it as well?Ardem Patapoutian (08:59):That's all TRPA1, yeah.The Discovery, A Test of PerseveranceEric Topol (09:01):It's wild. Now, this was the groundwork. There were these heat temperature and somatic sensory, and then you were starting to wonder what about touch, what about out pressure and proprioception. And so, you went on a hunt, and it's actually kind of an incredible story about how you were able to find out of these cells that you had, screening hundreds or I guess you got to 72 different small interfering RNA blocking that you finally found the one. Is that right?Ardem Patapoutian (09:37):That's right. So in retrospect, looking back at it, I think there's such an interesting scientific message there. And so, many of us were looking for this touch pressure sensors and we were all looking in the DRG sensory neurons that are complicated heterogeneous, they don't divide. It's not easy to do a screen on them. And ultimately after a lot of failures, what worked for us is to take a step back and ask a much more simpler question. And that was, can we find one of these cell lines that you could easily homogeneously grow in a culture dish, if they respond to mechanical force, can we find our channel there? And then go back and look if it's relevant in vivo for what process. So I think the message is ask the simplest question to answer the question you're after. And finding what that is, is actually the challenge lots of times.Ardem Patapoutian (10:36):But yeah, that's what Bertrand Coste in my lab did is found a simple cell line that neuroscientists had been using for a hundred years and somehow found that they over overexpressed this channel because you can record from them, you can push them and record the currents from them. And then it became a simpler question of finding it. It still took a whole year. He made a list and one by one knocking them out and looking at it. And finally, as you say, number 72 was the hit. When he knocked that out, the current was gone. And that's where we started believing that we have what we were looking for.Eric Topol (11:12):Were you all ever about ready to give up at that point?Ardem Patapoutian (11:16):Oh yeah. I mean that's another lesson. These are postdocs doing the work, right? And they're here three, four years and this was coming close to end of two years, and he didn't have anything yet. So we started talking about having a backup project and he started that and we said, okay, we were ordering this oligos 30 at a time because they're expensive. And so, the first 30 nothing, the second 30 nothing. And how many more are we going to do before we potentially give up? And we said, well, let's do at least a third and then decide, thank goodness it was in that last set.Eric Topol (11:54):Wow, that is so wild. Now what's happened since this discovery, which I guess when you published it in 2010, so it means 14 years ago, but we're on this exponential growth of learning that these piezo receptors are everywhere. They're doing everything. In fact, I recently put on Bluesky, PIEZO ion channels are to human physiology as GLP-1 drugs are to treating many diseases because it's just blowing up. And you've published on some of these of course, on itch and bladder function and vascular function. We'll get to maybe malaria, I mean, but even the cover of Science recently was about wet dog shakes and how animals shake because of water. These receptors are so fundamental to our function. So maybe you could comment, 15 years ago when you were doing the work and you're making this discovery, did you ever envision it was going to blow up like this?Ardem Patapoutian (12:57):Not to this level, but I should have. I think that this idea, again, that most of cell communication is through chemicals is of course a lot of it is true.Ardem Patapoutian (13:12):But it would be ridiculous for evolution to ignore all the physical forces, the pressures that cells experience. And once they do, you would think you would put an instructive way of sensing this pressure signal and using it beneficially to the system or the cell. And so, when we used to talk about pressure sensing at the beginning, there were a couple of touch, pain, maybe proprioception, hearing are like the poster children of pressure sensing. But I think what these molecules, as you say is enabling us is finding out the much more wider role that pressure sensing is playing in physiology and in disease that no one had thought seriously about. And this is, I compare sometimes the finding the PIEZO molecules. You're going in a dark room, and you need to find a door to get into there. And PIEZO is kind of that finding the door once you get in, now you use that molecule now to find physiology instead of the opposite way around. So by pursuing PIEZO expression and function, we're finding all these new roles that they play in physiology and in disease that we didn't think about. And because they're so specialized to sense tension, membrane tension, they don't do anything else. So if you see them expressed somewhere or if you see a function for them, you can bet that they are playing a role in sensing pressure. A lot of biology has kind of come from this hypothesis.Eric Topol (15:00):Well, I mean it is so striking to see the pervasiveness, and I do want to go back just for a second because when you name them PIEZO, you named it after the Greek word. How did you come to that name?Ardem Patapoutian (15:13):So Bertrand and I were actually sitting on Google Translate and we were typing pressure and trying to see what it's like in Greek or in Latin or different languages. His native French and my Armenian and píesi in Greek is pressure. And of course, what's really cool is that the word that more people know about this is piezoelectric device.Eric Topol (15:41):Oh, right.Ardem Patapoutian (15:41):Actually, translates physical force into electricity and vice versa. And in a way, this is a little molecular machine that does the same thing, and he uses this piezoelectric device to actually push on the cell. That's his assay. So it all came together as a very appropriate name for this gene and protein.Call from the Nobel CommitteeEric Topol (16:04):Oh really, it's perfect. And you get to name it, even that's fun too, right? Now we're going to go to getting the call at 2:00 AM, but it didn't come to you because your phone from the Nobel Committee was on ‘do not disturb' and your 94-year-old father, Sarkis. How did the Nobel Committee know to get ahold of him? How did they reach him in the middle of the night?Ardem Patapoutian (16:37):Yeah, so I mean, since receiving it, I've had conversations with various committee members, and they are very resourceful folks, and they have assistants who throughout the year collect information on all potential people who might win. They're also doing last minute searches. So they looked for other Patapoutian's in California. So they just called my dad who initially yelled at them for disturbing him at 2:00 AM.Eric Topol (17:17):And he could get through to you because he was not on your list of ‘do not disturb' or something like that.Ardem Patapoutian (17:22):I didn't even know this. And I don't know if the policy has changed, but in some phones the ‘do not disturb' if it's called by someone who's in your contacts or favorites.Ardem Patapoutian (17:34):After I think they called twice and they get through, and that's how.Getting a Tattoo!Eric Topol (17:39):That's amazing. Wow. Well, that's quite a way to find out that you're getting recognized like this. Now recently you got a tattoo, which I thought was really remarkable, but we're going to put that of course in the post. Tell us about your decision to get the PIEZO channel on your arm.Ardem Patapoutian (18:02):So as you can tell, I'm obsessed about PIEZO and it's been good to me. And I had the idea a while ago, and my very wise wife, Nancy Hong, said that you might be going through midlife crisis. Why don't you wait a year? If you still believe in it, you should do it. And that's what I did. I waited a year, and I was like, I still want to do it. And I guess I could show it. Here it is.Eric Topol (18:32):Oh yeah, there it is. Oh wow.Ardem Patapoutian (18:33):What's cool is that I can pretty much flex to show the activation mechanism because the channel is like bent like this in the plasma membrane. When it's stretched, it opens and it actually flattens like this. So I feel like other than being a tattoo, this is both performance art and instructional device. When I'm giving talks without PowerPoint slides, I could give a demonstration how this ion channel works.[Below is from a presentation that Ardem recently gave, the Harvey Lecture, at Rockefeller University.]Eric Topol (19:04):It's wild. Now how did you find a tattoo artist that could, I mean, it's pretty intricate. I mean, that's not your typical tattoo.Ardem Patapoutian (19:14):Yeah, I put it up on social media that I was thinking of doing this, and many scientists are into tattoos, so I actually got so many recommendations. And one of them was a local here in San Diego, and she is very popular. I waited six months to get this, I was on a waiting list. The appointment was six months off when we made it. So she's very popular and she's very good.Eric Topol (19:45):Was it painful to get that done?Ardem Patapoutian (19:47):Well, that's actually really cool, right? Because PIEZO2 is involved in pain sensation, and I felt it while it was being tattooed on my arm. The whole day, I was there like six and a half hours.New Prospect for Pain MedicationEric Topol (20:00):Oh my gosh. Wow. Now that gets me to pain because, I'd like you to talk a bit about the people that don't have mutations or loss of function PIEZO receptors and also what your thoughts are in the future as to maybe we could develop a lot better pain medications.Ardem Patapoutian (20:22):Yeah, we're working on it. So you're right. One of the great parts of the science story, and this is mainly the work of Alex Chesler and Carsten Bönnemann at the NIH, where they identified people who came to the clinic for undiagnosed conditions, and they were uncoordinated and had difficulty walking. And when they did whole-exome sequencing, they found that they had mutations in PIEZO2, there were loss of function, as you say. So complete loss on both chromosomes. And when they started testing them, they realized that just like we had described them in animal models, humans without PIEZO2 as well, didn't sense touch, don't have proprioception. This sense of where your limbs are, that's so important for balance and most other daily functions that we take it for granted. So they were completely lacking all of those sensations. They also do not feel their bladder filling.Ardem Patapoutian (21:26):And so, they have learned to go on a schedule to make sure they don't have accidents. And many of these projects that we've done in the lab collaboration with Alex Chesler, et cetera, have come from the observations of what else these individuals experience. And so, it's been a great kind of collaboration communication between mechanistic animal model studies and the clinic. And so, one of the things that these individuals don't sense in addition to touch, is something called tactile allodynia, which is simply when touch becomes painful. You and I experienced this after small injury or sunburn where just touching your shoulder becomes painful, but for peripheral neuropathy and other neuropathic pain conditions, this is one of the major complaints that individuals have. And we know from the NIH studies that these individuals don't have this tactile allodynia. So touch becomes painful and doesn't apply to them, which tells us that if we block PIEZO2, we can actually get interesting relief from various aspects relative to neuropathic pain on other pain related neuropathies. But given everything we talked about, Eric, about how this is important for touch and proprioception, you don't want to make a pill that blocks PIEZO2 and you take it because this will have some serious on target side effects. But we are developing new compounds that block PIEZO2 and hope that it might be useful, at least as a topical medication pain and other indications. And we're actively working on this, as I said.Eric Topol (23:15):Yeah, I mean the topical one sounds like a winner because of peripheral neuropathy, but also I wonder if you could somehow target it to sick cells rather than if giving it in a systemic targeted way. I mean it has tremendous potential because we are on a serious hunt for much better relief of pain than exists today.Ardem Patapoutian (23:41):Absolutely.Eric Topol (23:42):Yeah. So that's exciting. I mean, that's another potential outgrowth of all this. Just going back, I mean the one that prompted me in November to write that about the human physiology in PIEZO, it was about intestinal stem cell fate decision and maintenance. I mean, it's just everywhere. But the work you've done certainly now has spurred on so many other groups to go after these different and many unanticipated functions. Were there any ones, of course, you've been pretty systematically addressing these that actually surprised you? You said, oh, are you kidding me when you read this? I never would've guessed this, or pretty much they followed suit as things were moving along.Ardem Patapoutian (24:33):So one of them is this role in macrophages that I found fascinating that we found a few years ago. So again, this came from human studies where PIEZO1 gain-of-function mutations. So in relation to loss of function, their gain-of-function where there's more activity given a certain amount of pressure. They have dehydrated red blood cells, which I'm not going to talk about right now. But they also have shown that in these patients, individuals, it's not really that pathological. They also have age-onset iron overload. What does that have to do with pressure sensing? And we brought that information into animal models, and we found that macrophages, their rate of phagocytosis depends on PIEZO, so that if you have too little PIEZO, they don't phagocytosis as much. If you have too much PIEZO, the phagocytosis too much. And this increased rate of phagocytosis in the long term because it's constantly eating red blood cells and the iron is circulating more causes long-term effects in iron overload. And again, as you kind of set that up, who would've thought that mechanical sensation is important for this basic hematology type?Eric Topol (25:52):Yeah, I mean, because we've been talking about the macro things, and here it is at the cellular level. I mean, it's just wild.Ardem Patapoutian (25:59):If you go back and look at a video of a macrophage eating up red blood cells, then you go, oh, I see how this has to do with pressure sensing because it is like extending little arms, feeling things letting go, going somewhere else. So again, I want to bring it back by this simple cell biological function of a cell type, like macrophage, exploring its environment is not just chemical, but very mechanical as well. And so, in retrospect, it is maybe not that surprising, that pressure sensing is important for its physiology.Career Changing?Eric Topol (26:33):Yeah, that's extraordinary. Well, that gets me to how your life has changed since 2021, because obviously this a big effect, big impact sort of thing. And I know that you're the first Armenian, first person from Lebanon to get this recognition. You recognized by the Lebanese Order of Merit. There's even a stamp of you, your picture characterized in 2022.Eric Topol (27:04):So if you were to sum up how it's changed because I see no change in you. You're the same person that has a great sense of humor. Often the tries to humor relaxed, calming. You haven't changed any to me, but how has it affected you?Ardem Patapoutian (27:26):Thank you, Eric. That's very kind of you. I try very hard for it not to change me. I do get a little bit more attention, a ton more invites, which unfortunately I have to say no to a lot of them because, and I'm sure you're very familiar with that concept and a lot of things are offered to you that I feel like it's so tempting to say yes because they're wonderful opportunities and an honor to be asked. But the end of the day, I'm trying to be very disciplined and not taking things on that I can do as an opportunity. But things that I really want to do. I think that's so hard to do sometimes is to separate those two. Why am I doing this? Is this really important for the goals that I have? So in one way, the answer for that is that I just want to stay in the lab and do my research with my students and postdoc, which is what I enjoy the most. But on the other hand, as you said, being the first Armenian who's received this, literally after the Nobel, I got this whole elementary school, all Armenian kids write to me multiple letters.Ardem Patapoutian (28:39):And they said, you look like me. I didn't think I could do this, but maybe I can. So in a sense, to ignore that and say, no, I just want to do my science, I don't want to be involved in any of that is also wrong. So I'm trying to balance being engaged in science outreach and helping to make science understood by the general public, realize that we're just regular people and at the same time how awesome science is. I love science and I like to project that, but leave plenty of time for me to just be a scientist and be in my lab and interact with my colleagues at Scripps, including you.Immigrant ScientistsEric Topol (29:21):Well, we're so lucky to have that chance. And I do want to mention, because you're prototyping in this regard about great immigrant scientists and other domains of course, but every year the Carnegie Foundation names these great immigrants and one year you were of course recognized. And in recent years, there have been more difficulties in people wanting to come to the US to get into science, and they wind up going to other places. It seems like that's a big loss for us. I mean, what if we weren't able to have had you come and so many hundreds, thousands of others that have contributed to this life science community? Maybe you could comment about that.Ardem Patapoutian (30:10):Yeah, I think it is tragic, as you say. I think in some circles, immigrants have this negative image or idea of what they bring, but at every level, immigrants have contributed so much to this country. It's a country of immigrants, of course, to start with. And I think it is important to put up a positive image of immigration and science is the ultimate example of that, right? I mean, I think when you go into any laboratory, you probably find if there's a lab of 16 people, you probably find people from 10 different countries. And we all work together. And the idea of also immigrant and especially about science is that I'm a big believer of changing field, changing things because just like that, immigrants have changed their whole life. So they come to a new culture, they bring with them their own way of thinking and their way of seeing things. And then you come into a new environment, and you see it a little bit differently. So that kind of change, whether it's because of physical immigration or immigrating from one field to another in science is really beneficial for science and society. And I think positive examples of this are an important part of highlighting this.Eric Topol (31:40):I couldn't agree with you more really.Bluesky vs Twitter/XEric Topol (31:41):Now, speaking of migration, there's been recently a big migration out of X, formerly Twitter to Bluesky, which I like the metaphor you liken to the Serengeti. Can you tell us about, now I know you're posting on Bluesky and of course so many others that you and I are mutual contacts, and our different networks are. What do you think about this migration outside of what was the platform where a lot of this, we shared things on X or before Musk took over known as Twitter? Thoughts about Bluesky?Ardem Patapoutian (32:27):Yeah, I think I use social media for a few reasons. The number one reason should be is to see new science by colleagues. My main point is that, but also, again, having fun in science is a big part of my draw to this. And as you can see from my posts, it's a bit lighthearted, and that's really me.Eric Topol (32:52):Right. Yeah.Ardem Patapoutian (32:52):I think on Twitter, things start getting a little bit dark and too many negative comments, and it was just not productive. And I just felt like after the elections, I felt like it was time to migrate. And I find Bluesky a great scientific community, and it's remarkable how quickly people have migrated from Twitter to Bluesky. But the counter argument for this is that you should stay in a place where majority of people are, because being in a bubble surrounding yourself by people like you doesn't help society. And so, I get that perspective as well. It just depends on what you're using the platform for and it's a difficult issue. But yeah, I've taken a break probably long-term break from Twitter. I'm on Bluesky now.Eric Topol (33:48):Yeah, no, the point you're bringing up about the echo chamber and is there going to be one for people that are leaning one way and they're thinking, and another with a whole different, often politically charged and even extreme views? It's really unfortunate if it does wind up that way. But right now, it seems like that migration is ongoing and it's substantial. And I guess we'll see how it settles out. I share your concern, and so far, I've been trying to keep a foot in both areas because I think if we all were to leave, then we're just kind of caving into a, it's tricky though. It really is because the noxious toxic type of comments, even when you try to avoid comments, you say, only followers can make a comment, they'll of course, quote your thing and then try to ding you and whatever. It's just crazy stuff, really.Ardem Patapoutian (34:53):I mean, what I think is that, that's why I said depends on why. I mean, your presence on social media is such an important part of science education. And I could almost say you can't afford to do what I do, which is I'm just putting my goofy posts and having fun. So we have different purposes in a way, and yeah, that affects what you use and how you use it.Eric Topol (35:17):Yeah, no, it's tricky it really is. We covered a lot of ground. Is there anything I missed that you want to get out there? Any part of this, your story and the PIEZO story, science and everything else that I didn't bring up?The Essentiality of Basic ScienceArdem Patapoutian (35:42):I just think that the basic science community is really suffering from decreasing amounts of funding and appreciation of doing basic science. And one of my goals, in addition to this immigrant scientist thing, is to remind people that all medicines start with basic science work. And funding this has mainly been through NIH and it's getting harder and harder for basic scientists to secure funding and I'm really worried about this. And we need to find ways to be okay for people to do basic science. And I'll give you one example. Whenever we make a publication and there's a journalist talking to us or some kind of press coverage, they ask, how is this directly affecting patients? And my work actually is very much related to patients, and I answer that question, but I also say, but it's also important to do science for the science sake because you don't know where the applications are going to come from. And we need to, as a society, encourage and fund and support basic science as the seeds of all these translational work. And I think doing that just kind of highlights that this is important too. We should support it, not just things that right now seem very related to translational that directly helps patients.Eric Topol (37:16):Well, I'm so glad you emphasized that because I mean, the PIEZO story is the exemplar. Look what's come of it, what might still come of it. In many respects here you are maybe 15 years into the story and there's still many parts of this that are untold, but if it wasn't for the basic science, we wouldn't have these remarkable and diverse insights. And recently you cited, and I think so many people read about the ‘crown jewel' NIH, front page New York Times, and how it's under threat because the new NIH director doesn't have a regard for basic science. He's actually, he's confirmed, which is likely, he's an economist, physician economist, never practiced medicine, but he doesn't really have a lot of regard for basic science. But as you point out, almost every drug that we have today came out of NIH basic work. And I mean, not just that, but all the disease insights and treatments and so much.Eric Topol (38:25):So this is really unfortunate if we have not just an NIH and other supporting foundations that don't see the priority, the fundamental aspect of basic science to then lead to, as we call translational, and then ultimately the way to promote human health, which is I think what we're all very much focused on ultimately. But you can't do it without getting to first base, and that's what you have done. You served it up and it's a great example. Well, Ardem, it's always a pleasure. This is a first time talking through a podcast. I hope we'll have many, many visits informally that will complement the ones we've already had, and we will follow the PIEZO work. Obviously, you have had just an exceptional impact, but you're still young and who knows what's next, right? I mean, look what happened to Barry Sharpless. He won here. He won two Nobel prizes, so you never know where things are headed.Ardem Patapoutian (39:36):Thank you, Eric, and I really appreciate what you do for the biomedical community. I think it's wonderful through your social media and this podcast, we all appreciate it.***********************************************************************************Please take a moment to complete the poll above.Thank you for reading, listening and subscribing to Ground Truths.If you found this informative please share it!All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and of course appreciated. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. 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Today's return guest is a Mark O. Hatfield (R, Oregon) type of Republican, Dr. Vernon Grounds, Ph.D., former Chancellor, President, and long-time professor of Philosophy and Psychology, and founder of the Counseling Department at Denver Seminary, where TRP's host Dr. Lucas J. Mather, Ph.D. knew Dr. Grounds during Dr. Mather's graduate student days. Dr. Grounds taught in the philosophy department as well courses on Existentialism and Christian worldview. Our topic today on The Republican Professor Podcast is emotional problems and American Politics. Last Fall, we did a series on Anxiety and American Politics. Last Spring we did a series on Hatred and Anger in the Normative Christian Tradition. We return today with a focus on the concepts and phenomena of Pride in Biblical and Political Phenomenology in the American context. You've probably noticed the relevance to American Politics if you're paying attention. I can think of no better guest than Dr. Grounds, who is a rare bird in that he was one of the first to get the in depth Psychology training--a Ph.D. in Psychology--and applied that to Christian ministry and Apologetics. Dr. Grounds got his bachelors from Rutgers during the Great Depression, and struggled mightily with his Christian faith. He got seminary training, and later a Ph.D. in Psychology from Drew University, where he wrote a dissertation on the concept of love in the thought of Sigmund Freud. He wrote several books, but the one we discuss and read from today is his "Emotional Problems and the Gospel" (Zondervan, 1976). The Amazon link is here: https://www.amazon.com/Emotional-Problems-Gospel-Vernon-Grounds/dp/031025311X/ref=sr_1_1?crid=173GZ03N0T8JF&keywords=vernon+grounds+emotional&qid=1698937363&s=instant-video&sprefix=vernon+grounds+emotional%2Cinstant-video%2C124&sr=1-1-catcorr Since Dr. Ground died before we were able to record this with him, he joins this episode through his chapter in the above book, which he titled "The Bible and Pride, Part 2." The Republican Professor is a pro-mental-health-in-politics, pro-ultimate-issues podcast. Therefore, welcome Dr. Vernon Grounds, Ph.D. To financially support this podcast with a donation, visit https://buymeacoffee.com/lucasj.mather or on Venmo at TheRepublicanProfessor Every cent goes a long way, so thank you. Warmly, Lucas J. Mather, Ph.D. The Republican Professor Podcast The Republican Professor Newsletter on Substack https://therepublicanprofessor.substack.com/ https://www.therepublicanprofessor.com/podcast/ https://www.therepublicanprofessor.com/articles/ YouTube channel: https://www.youtube.com/@TheRepublicanProfessor Facebook: https://www.facebook.com/TheRepublicanProfessor Twitter: @RepublicanProf Instagram: @the_republican_professor
To Celebrate being named the #1 Fishing Podcast of 2024 by FeedSpot, I wanted to take welcome some new listeners (and old!) with a trip down memory lane as some of my favorite moments in TRP History! I've had the privilege of talking to tons of great guests throughout the years about a wide range of topics. These are a few of the immediate standouts that came to my mind. Who has been your favorite TRP guest and who do you want to see in the future? Text me at 305-930-7346 or email at podcast@saltwaterexperience.com. Check out the links for all the shows mentioned in this episode! Bill Dance Michael Chandler Forrest Gallante Michael Waddell John Nores Ray Cash Care BlacktipH Clay Hayes Mark the Shark All of my other socials can be found here : https://linktr.ee/TomRowlandPodcast The Tom Rowland Podcast is presented by Star brite! Clean and protect with Star brite, a leading manufacturer of appearance, maintenance, and performance chemicals and accessories, serving the marine, RV, automotive, powersports, hardware, and home care industries for over 50 years. Headquartered in Fort Lauderdale, FL, and with its manufacturing plant in Montgomery, AL, the company produces "Made In The USA" products, including its flagship ethanol fuel treatment, Star Tron Enzyme Fuel Treatment. https://bit.ly/48tNW0y Learn more about your ad choices. Visit megaphone.fm/adchoices
Trpíš? Máš negativní myšlenky ohledně sebe sama? Cítíš se zasekle? Co když je to tím, že se ve své zkušenosti umisťuješ špatně? Pojď s námi prozkoumat povahu nejzajímavějších fenoménů jako je vědomí, koncept JÁ, zažívání blaženosti a meditace. Bavíme se s Jiřím Charvátem, autorem knihy o probuzení pro skeptiky "Jak se stát nikým?". A Jirka tvrdí, že se můžeme ušetřit drtivou většinu vlastního utrpení. Jak na to? A je Vaše vědomí jenom trik? Pusťte si dnešní podcast a dozvíte se mnohem víc! Co je to “Záblesk” vědomí? Patří ti tvé myšlenky a akce? Můžeme být někdy šťastní? Parťákem dnešního dílu je GymBeam https://gymbeam.cz/ https://gymbeam.cz/ zadej kód BWA5 pro 5% slevu a koukni na naše oblíbené produkty od proteinů, až po nootropika. NAPSALI JSME KNIHU! Svět Levného Dopaminu - seženete ji ve všech knihkupectvích. Odebírej krátký VIP formát na našem Spotify jen za stovku / měsíc. Odemkneš jich tím rovnou 36! Nejdůležitější koncepty a uvědomění do 10 minut! https://podcasters.spotify.com/pod/show/brainweare/subscribe Uplife.cz - Zadej kód "BWA" pro slevu 10% na vybrané zboží na eshopu https://www.uplife.cz/brain-we-are/ Sledujte Brain We Are na sociálních sítích: Instagram nebo Facebook Přihlaš se na naší Půlroční Akademii 2025 v druhé vlně prodeje se slevou 1400,- Minutáž: 3:28 Kdo je Jiří Charvát 8:00 Co je to sen o “JÁ” 10:05 Faleš! Patří ti tvé myšlenky a akce? 12:30 Ego a Já - Další hobaďůra našeho mozku 16:17 Jsme šprajcnutí mezi dvěma světy 19:54 Jak se umisťujeme & Jak je to “správně” 23:12 Všímavost & Příběhy 25:41 Co je to “Záblesk” vědomí? 27:45 Pohled na život jako na plátno v kině 31:29 Klid & Nuda jsou sousedi 33:48 Můžeme být někdy šťastní? 40:20 Stejně tíhneme k rodičovství 42:08 Uvědomnění svobodné vůle & Ohnisko kontroly 47:36 Zpět k houbičkám a otcovství 52:04 Limitující mysl VS Společnost s bezlimitní myslí - Citát 55:01 Co je to “Budhův boďák” 55:53 Vliv neurovědce Anil Setha na výzkum vědomí 59:48 Experimenty s umisťováním svého “JÁ” 1:03:32 Fantomová bolest 1:05:59 Náš prediktivní mozek 1:10:15 Myšlenkové experimenty a mravenci! 1:16:47 Ego má bobky - z knihy Jiřího Charváta 1:20:01 Optimalizace “JÁ” které vzpomíná a které prožívá 1:29:02 Naše Příběhy & Role 1:31:41 Jaký vliv má na tebe život ve městě 1:32:50 Levný dopamin 1:33:13 Jak používáš sociální sítě? 1:36:37 Split brain experiment 1:41:19 Naše mysl je modulární 1:47:55 Závěr
Today's return guest is a Mark O. Hatfield (R, Oregon) type of Republican, Dr. Vernon Grounds, Ph.D., former Chancellor, President, and long-time professor of Philosophy and Psychology, and founder of the Counseling Department at Denver Seminary, where TRP's host Dr. Lucas J. Mather, Ph.D. knew Dr. Grounds during Dr. Mather's graduate student days. Dr. Grounds taught in the philosophy department as well courses on Existentialism and Christian worldview. Our topic today on The Republican Professor Podcast is emotional problems and American Politics. Last Fall, we did a series on Anxiety and American Politics. Last Spring we did a series on Hatred and Anger in the Normative Christian Tradition. We return today with a focus on the concepts and phenomena of Pride in Biblical and Political Phenomonenology in the American context. You've probably noticed the relevance to American Politics if you're paying attention. I can think of no better guest than Dr. Grounds, who is a rare bird in that he was one of the first to get the in depth Psychology training--a Ph.D. in Psychology--and applied that to Christian ministry and Apologetics. Dr. Grounds got his bachelors from Rutgers during the Great Depression, and struggled mightily with his Christian faith. He got seminary training, and later a Ph.D. in Psychology from Drew University, where he wrote a dissertation on the concept of love in the thought of Sigmund Freud. He wrote several books, but the one we discuss and read from today is his "Emotional Problems and the Gospel" (Zondervan, 1976). Since Dr. Ground died before we were able to record this with him, he joins this episode through his chapter in the above book, which he titled "The Bible and Pride, Part 1." The Republican Professor is a pro-mental-health-in-politics, pro-ultimate-issues podcast. Therefore, welcome Dr. Vernon Grounds, Ph.D. To financially support this podcast with a donation, visit https://buymeacoffee.com/lucasj.mather or on Venmo at TheRepublicanProfessor Every cent goes a long way, so thank you. Warmly, Lucas J. Mather, Ph.D. The Republican Professor Podcast The Republican Professor Newsletter on Substack https://therepublicanprofessor.substack.com/ https://www.therepublicanprofessor.com/podcast/ https://www.therepublicanprofessor.com/articles/ YouTube channel: https://www.youtube.com/@TheRepublicanProfessor Facebook: https://www.facebook.com/TheRepublicanProfessor Twitter: @RepublicanProf Instagram: @the_republican_professor
We received tender mercies this past week. (Psalm 51, KJV). Here's the end of election week message from TRP bunker. Originally aired LIVE Friday 8 November 2024 at 1:21pm Buy the producer a coffee anonymously, https://buymeacoffee.com/lucasj.mather Warmly, Lucas J. Mather, Ph.D. The Republican Professor Podcast The Republican Professor Newsletter on Substack https://therepublicanprofessor.substack.com/ https://www.therepublicanprofessor.com/podcast/ https://www.therepublicanprofessor.com/articles/ YouTube channel: https://www.youtube.com/@TheRepublicanProfessor Facebook: https://www.facebook.com/TheRepublicanProfessor Twitter: @RepublicanProf Instagram: @the_republican_professor