Podcasts about cerebrospinal fluid

20% of all adults suffer from chronic pain, while up to 80% will experience acute pain from injury or surgery.   $600 billion is spent annually in health care costs and loss of productivity due to pain.  In this episode, you'll discover:—Dr. Prather's theory that pain comes from a blockage of energy in one or more of The 5 Pathways Of Pain.  And how each pathway needs to be treated in a different way. —Why Dr. Prather says his patients will first feel an increase in their energy level before they feel a decrease in their pain level.—How 80% of chronic Headache patients have actually given up on finding a solution, but Dr. Prather says that his office is "pretty much 100% successful" with Headaches.—The difference between the medical approach of pain management that masks the symptoms versus the Structure-Function approach of actually fixing the underlying cause of the pain.—Why Opioids and NSAIDs actually "make the pain problem worse" long-term by damaging the body.  And the long list of natural, safe, non-pharmaceutical alternatives Dr. Prather uses in his office that produce better results than the drugs.—How the treatments offered by Holistic Integration are exactly what an independent government commission recommended as the best approach to pain…until the pharmaceutical companies interfered.—Why Dr. Prather says that "Chiropractic is one of the best things you can do" when you're talking about pain relief.  And the reason why Holistic Integration begins with making sure the Atlas is in its proper position.—How Acupuncture "can actually reverse" Opioid addiction by stimulating the body's own natural Opioid production.  And how "everybody" has some issues with a blockage of their Electromagnetic pathway, which makes the biggest difference for Chronic Pain patients.—The link between the Lymphatic pathway of pain and Fibromyalgia, for which Dr. Prather's office gets "remarkable results".  And how the B Vitamins are particularly effective for Nerve Pain. —The Cerebrospinal Fluid blockage that is "easy to diagnose" and is "a different type of pain" which responds well to Craniosacral Therapy at Holistic Integration.  And how Dr. Prather considers a lot of the deep joint pain as a blockage of the Circulatory pathway, which can be treated by "pumping" the joint.http://www.TheVoiceOfHealthRadio.com

Thanks to some forgetful old mice we now know which delicious protein floating around our bodies can help improve recall. And thanks to Aroma Researchers we now know the chemicals behind Eau De Teen. — Support and sponsor this show! Venmo Tip Jar: @WellThatsInteresting Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@wellthatsinterestingpod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Bluesky: @wtipod Threads: @wellthatsinterestingpod Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@wti_pod⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Listen on YouTube!! Oh, BTW. You're interesting. Email YOUR facts, stories, experiences... Nothing is too big or too small. I'll read it on the show: wellthatsinterestingpod@gmail.com WTI is a part of the Airwave Media podcast network! Visit AirwaveMedia.com to listen and subscribe to other incredible shows. Want to advertise your glorious product on WTI? Email me: wellthatsinterestingpod@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

We are excited to host  Mauro Zappaterra on this episode of the Mangu.tv podcast. Mauro Zappaterra, MD, PhD, earned his degrees from Harvard Medical School and specialises in physical medicine and rehabilitation, focusing on human performance, awareness, and pain reduction. Pra ctising mindfulness since 1998, he has taught it to chronic pain patients since 2018. As Director of Multidisciplinary Care at Synovation Medical Group, he integrates new research on cerebrospinal fluid and pain management. Dr. Zappaterra has authored numerous scientific papers and books, including I Am, All One, All Love, and Close Your Eyes, What Do You See? co-written with his son, emphasising awareness and imagination. His alphabet book, A is for Awareness, and programs like Awakening Awareness reflect his dedication to mindfulness, healing, and expanding consciousness. Mauro shares the story of his upbringing, and early curiosity in human development and the power of the mind. He speaks about his studies in molecular biology and dissatisfaction with the format of his learning thus leading him down the holistic path and Craniosacral therapy which informed his PhD in Cerebrospinal fluid.  Giancarlo and Mauro discuss the mystical and scientific significance of cerebrospinal fluid as well as ways to tune into this fluid and space through breath and meditation.  Mauro shares his philosophy that by doing these practices, we understand who we truly are, and the connection with the totality of the universe.

Today, we're exploring a groundbreaking new study that challenges the long-held belief of a rigid separation between the central nervous system (CNS) and the peripheral nervous system (PNS). This research reveals how cerebrospinal fluid (CSF) extends to peripheral nerves, highlighting a unified system that could reshape our understanding of nerve health and pathologies. We'll explore what this means for chiropractors and healthcare providers, discuss the study's implications, and provide actionable insights for your practice.Episode Notes: Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous systemJane is an online platform for health and wellness practitioners that makes it simple to book, chart, schedule, bill, and get paid. I you're ready to get started, click here and use the code EBC1MO for a 1-month grace period on your new account.The Best Objective Assessment of the Cervical Spine- Provide reliable assessments and exercises for Neuromuscular Control, Proprioception, Range of Motion, and Sensorimotor-Integration. Learn more at NeckCare.comPatient Pilot by The Smart Chiropractor is the fastest, easiest to generate weekly patient reactivations on autopilot…without spending any money on advertising. Click here to schedule a call with our team.Our members use research to GROW their practice. Are you interested in increasing your referrals? Discover the best chiropractic marketing you aren't currently using right here!

In this episode of Tiny Show and Tell Us, we cover neurogenesis in adulthood (yes! your brain can make new neurons even as you age), the link between exercise and increased neurogenesis in the hippocampus, and the implications that could have for neurodegenerative diseases like Alzheimer's. We continue on our brain-focused episode with the role cerebrospinal fluid plays in cleaning out your brain while you sleep and how its movement is in fact influenced by your brain waves.We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story for a chance to be featured in a future episode and win a Tiny Matters mug!

Looking 4 Healing Radio with Nichola Burnett – It is quite astonishing how accurate Chinese Medicine practitioners can be in regards to finding health issues by just looking at these types of markers. How is it possible? The fingernail of an adult takes 6-8 months to grow and reflects a person's physical condition in many ways. Nails are the transfer points for all nutrients, so many physical deficiencies can be recognized in the appearance of...

Looking 4 Healing Radio with Nichola Burnett – It is quite astonishing how accurate Chinese Medicine practitioners can be in regards to finding health issues by just looking at these types of markers. How is it possible? The fingernail of an adult takes 6-8 months to grow and reflects a person's physical condition in many ways. Nails are the transfer points for all nutrients, so many physical deficiencies can be recognized in the appearance of...

Enjoy this episode? Please share it with at least ONE friend who you think needs to hear it! If you're a longtime listener of The Way Forward, you know how excited I get when I have guests on who talk about water and its relation to consciousness, health, and the nature of reality. In this episode, Alec is joined by Mauro Zappaterra, MD, PhD, to explore the relationship between our 4th-phase water, Cerebral Spinal Fluid (CSF), consciousness, the soul, Kundalini Yoga, Kundalini awakening, breathwork, and God. CSF is a fluid that surrounds and cushions the brain and spinal cord, playing a crucial role in their function. But, according to Dr. Zappaterra and his work, the purpose and importance of CSF is likely beyond anything we're told. Mauro Zappaterra obtained his MD and PhD from Harvard Medical School. He is board-certified in physical medicine and rehabilitation with a focus on optimizing human performance, increasing awareness and decreasing suffering. He has been practicing mindfulness since 1998, and teaching mindfulness to patients with chronic pain since 2018, and he is the Director of Multidisciplinary Care at Synovation Medical Group. He has led the Awakening Awareness Program and Inward Inquiry for the Emerging Sciences Foundation which can be found on YouTube.  He has published numerous scientific papers and medical book chapters on the cerebrospinal fluid, disability, and pain management. He has also published "I Am", "All One", and "All Love" which are three books exploring topics of awareness, primarily for kids, but really for people of all ages.  He has also published "Close Your Eyes, What Do You See?" with his son, which is a story about imagination and intention.  And he also published "A is for Awarness", a new alphabet book to expand your consciousness vocabulary.  He continues to create programs to help patients with chronic pain and investigate the cerebrospinal fluid and integrate new research to evolve the hypothesis of The Cerebrospinal Fluid and I Am. ————————— The Way Forward podcast is sponsored by: ORGANIC MUSCLE: Organic Muscle is revolutionizing sports nutrition by exclusively utilizing non-GMO ingredients from USDA Organic farms. 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Enter code ZECK10 at checkout for 10% off.  Check out last year's aftermovie: https://youtu.be/TqL2wVBKuo0?si=kC6hTJxZWdPn6HSv For more on The Way Forward, please visit: https://thewayfwrd.com Visit our online marketplace for discounts on a variety of the best holistic health brands and products: https://thewayfwrd.com/store/ For all of our links, visit: https://www.flowcode.com/page/thewayforward Support The Way Forward and Alec's work: https://thewayfwrd.com/donate/ FIND YOUR PEOPLE! Join The Way Forward to connect with like minded men and women near you, businesses near you, and more! The best part? You pay whatever you want!: https://thewayfwrd.com/membership-sign-up/ Do you run a freedom-oriented or holistic health-oriented business? Join our FREE business directory here:  https://thewayfwrd.com/directory-form/ You can watch The Way Forward Podcast on YouTube, Unite, Bitchute & Rumble Youtube: https://www.youtube.com/@TheWayFwrd Unite: https://unite.live/channels/the-way-forward/the-way-forward Bitchute: https://www.bitchute.com/channel/a3s3CiyELVd8/ Rumble: https://rumble.com/user/TheWayFwrd This material may not be published, broadcast, rewritten or redistributed in whole or in part without expressed written permission from The Way Forward, LLC. The purpose of this presentation is to convey information. It is not intended to diagnose, treat or cure a condition; nor is it to be considered medical or legal advice, opinion or recommendation. This information is presented in the spirit of service for all. Timestamps: The Bridge Between Spirit and Matter (0:00) Here I am but what else am I? (10:50) The constant cycle of creation and destruction (15:25) Divine Orchestration (20:33) Introduction to the research  (29:10) What happened during a craniosacral session (35:05) Cerebrospinal fluid and the realization (39:20) How breath affects the fluid (48:06) The bridge presentation (1:00:00) The fluid filled cavities of the brain (1:18:05) Breakdown on what cerebrospinal fluid is and where it resides (1:23:22) Where does cerebrospinal fluid come from (1:36:06) What is the role of CSF? (1:42:04) What causes the movement of CSF? (1:52:25) Our internal electrical generator (1:55:36)

Painexam Podcast Show Notes: Journal Club on "Ventricular Infusion and Nanoprobes Identify Cerebrospinal Fluid and Glymphatic Circulation in Human Nerves" Special Thanks to Robert Stall, MD Introduction: Welcome to another episode of the Painexam Podcast! In today's journal club edition, we delve into a fascinating study by Dr. Joel E. Pessa on cerebrospinal fluid (CSF) circulation in human nerves. Background: The study addresses the growing evidence of CSF circulation in human nerves and its implications in various conditions encountered by plastic surgeons. Conditions such as nerve transection, stretch injuries, and peripheral neuropathy may be related to dysregulation of the CSF system. Methods: Dr. Pessa and his team developed the ventricular infusion technique using buffered saline in 2017. The technique was applied to eight fresh cadavers before dissecting the median nerve. Fluorescent imaging and nanoprobe injections were combined with ventricular infusion in selected specimens. Results: The eight cadaver specimens (six female, two male) aged 46–97 underwent successful ventricular infusion. Ventricular cannulation was performed successfully using specific coordinates. Results suggest that CSF flows in neural sheaths, including pia meninges, epineurial channels, perineurium, and myelin sheaths (neurolemma). Conclusions: Ventricular infusion and nanoprobes effectively identify CSF flow in neural sheaths of human nerves. CSF flow in nerves is described as an open circulatory system occurring via channels, intracellular flow, and cell-to-cell transport associated with glial cells. Neural sheaths, including neurolemma, may play a role in glucose and solute transport to axons. The techniques showcased in this study can be utilized in anatomic dissection and live animal models and have been extended to the central nervous system to identify direct ventricle-to-pia meninges CSF pathways. Significance: This study opens new avenues for understanding the intricate mechanisms of CSF circulation in neural tissues. Plastic surgeons and researchers can benefit from these techniques in studying and addressing conditions related to CSF dysregulation in nerves. The findings have implications not only for nerve-related conditions but also for broader applications in the central nervous system. Closing: Thank you for joining us on this insightful journey through Dr. Joel E. Pessa's study. Stay tuned for more engaging discussions on pain management and neurology in future Painexam Podcast episodes! Reference Pessa JE. Ventricular Infusion and Nanoprobes Identify Cerebrospinal Fluid and Glymphatic Circulation in Human Nerves. Plast Reconstr Surg Glob Open. 2022 Feb 17;10(2):e4126. doi: 10.1097/GOX.0000000000004126. PMID: 35198353; PMCID: PMC8856590.

Painexam Podcast Show Notes: Journal Club on "Ventricular Infusion and Nanoprobes Identify Cerebrospinal Fluid and Glymphatic Circulation in Human Nerves" Special Thanks to Robert Stall, MD Introduction: Welcome to another episode of the Painexam Podcast! In today's journal club edition, we delve into a fascinating study by Dr. Joel E. Pessa on cerebrospinal fluid (CSF) circulation in human nerves. Background: The study addresses the growing evidence of CSF circulation in human nerves and its implications in various conditions encountered by plastic surgeons. Conditions such as nerve transection, stretch injuries, and peripheral neuropathy may be related to dysregulation of the CSF system. Methods: Dr. Pessa and his team developed the ventricular infusion technique using buffered saline in 2017. The technique was applied to eight fresh cadavers before dissecting the median nerve. Fluorescent imaging and nanoprobe injections were combined with ventricular infusion in selected specimens. Results: The eight cadaver specimens (six female, two male) aged 46–97 underwent successful ventricular infusion. Ventricular cannulation was performed successfully using specific coordinates. Results suggest that CSF flows in neural sheaths, including pia meninges, epineurial channels, perineurium, and myelin sheaths (neurolemma). Conclusions: Ventricular infusion and nanoprobes effectively identify CSF flow in neural sheaths of human nerves. CSF flow in nerves is described as an open circulatory system occurring via channels, intracellular flow, and cell-to-cell transport associated with glial cells. Neural sheaths, including neurolemma, may play a role in glucose and solute transport to axons. The techniques showcased in this study can be utilized in anatomic dissection and live animal models and have been extended to the central nervous system to identify direct ventricle-to-pia meninges CSF pathways. Significance: This study opens new avenues for understanding the intricate mechanisms of CSF circulation in neural tissues. Plastic surgeons and researchers can benefit from these techniques in studying and addressing conditions related to CSF dysregulation in nerves. The findings have implications not only for nerve-related conditions but also for broader applications in the central nervous system. Closing: Thank you for joining us on this insightful journey through Dr. Joel E. Pessa's study. Stay tuned for more engaging discussions on pain management and neurology in future Painexam Podcast episodes! Reference Pessa JE. Ventricular Infusion and Nanoprobes Identify Cerebrospinal Fluid and Glymphatic Circulation in Human Nerves. Plast Reconstr Surg Glob Open. 2022 Feb 17;10(2):e4126. doi: 10.1097/GOX.0000000000004126. PMID: 35198353; PMCID: PMC8856590.

Painexam Podcast Show Notes: Journal Club on "Ventricular Infusion and Nanoprobes Identify Cerebrospinal Fluid and Glymphatic Circulation in Human Nerves" Special Thanks to Robert Stall, MD Introduction: Welcome to another episode of the Painexam Podcast! In today's journal club edition, we delve into a fascinating study by Dr. Joel E. Pessa on cerebrospinal fluid (CSF) circulation in human nerves. Background: The study addresses the growing evidence of CSF circulation in human nerves and its implications in various conditions encountered by plastic surgeons. Conditions such as nerve transection, stretch injuries, and peripheral neuropathy may be related to dysregulation of the CSF system. Methods: Dr. Pessa and his team developed the ventricular infusion technique using buffered saline in 2017. The technique was applied to eight fresh cadavers before dissecting the median nerve. Fluorescent imaging and nanoprobe injections were combined with ventricular infusion in selected specimens. Results: The eight cadaver specimens (six female, two male) aged 46–97 underwent successful ventricular infusion. Ventricular cannulation was performed successfully using specific coordinates. Results suggest that CSF flows in neural sheaths, including pia meninges, epineurial channels, perineurium, and myelin sheaths (neurolemma). Conclusions: Ventricular infusion and nanoprobes effectively identify CSF flow in neural sheaths of human nerves. CSF flow in nerves is described as an open circulatory system occurring via channels, intracellular flow, and cell-to-cell transport associated with glial cells. Neural sheaths, including neurolemma, may play a role in glucose and solute transport to axons. The techniques showcased in this study can be utilized in anatomic dissection and live animal models and have been extended to the central nervous system to identify direct ventricle-to-pia meninges CSF pathways. Significance: This study opens new avenues for understanding the intricate mechanisms of CSF circulation in neural tissues. Plastic surgeons and researchers can benefit from these techniques in studying and addressing conditions related to CSF dysregulation in nerves. The findings have implications not only for nerve-related conditions but also for broader applications in the central nervous system. Closing: Thank you for joining us on this insightful journey through Dr. Joel E. Pessa's study. Stay tuned for more engaging discussions on pain management and neurology in future Painexam Podcast episodes! Reference Pessa JE. Ventricular Infusion and Nanoprobes Identify Cerebrospinal Fluid and Glymphatic Circulation in Human Nerves. Plast Reconstr Surg Glob Open. 2022 Feb 17;10(2):e4126. doi: 10.1097/GOX.0000000000004126. PMID: 35198353; PMCID: PMC8856590.

You've just had your appointment with your neurologist or MS Specialist and you're on your way home, feeling like you weren't heard. Maybe there wasn't sufficient time. Or it might feel like your opinion simply isn't valued. Your frustration could even be the result of language issues and cultural barriers that make communication difficult. Whatever the reason, it doesn't have to be this way. Dr. Luis Manrique-Trujillo joins me this week to share tips and strategies that will improve the quality of communication between you and every member of your MS care team. Dr. Manrique-Trujillo is a neurologist specializing in neuroimmunology and multiple sclerosis at MedStar Georgetown University Hospital in Washington, D.C. We're also sharing some fascinating research that traces the gene variants that increase someone's risk of developing MS all the way back to the Bronze Age. We'll tell you about a small study that may explain how the Epstein-Barr Virus triggers MS. We'll tell you about a class-action lawsuit that accuses Pharmacy Benefit Managers of illegal collusion and price-fixing. (And we'll explain why this lawsuit could be a huge step toward lowering the cost of your prescription medications) And we're sharing our plans for RealTalk MS in 2024. We have a lot to talk about! Are you ready for RealTalk MS??! My New Year's Resolutions for RealTalk MS  :22 This Week: Improving communication between you and your neurologist  4:59 STUDY: Ancient DNA reveals how MS risk genes arose and spread across Europe  5:59 STUDY: EBV-specific T-cells may play a key role in developing MS  9:36 An important class-action lawsuit has been filed against Pharmacy Benefit Mangers  11:18 Dr. Luis Manrique-Trujillo shares strategies for improving communication between you and your neurologist   15:41 Share this episode  34:19 Have you downloaded the free RealTalk MS app?  34:40 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/333 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com STUDY: Elevated Genetic Risk for Multiple Sclerosis Emerged in Steppe Pastoralist Populations https://www.nature.com/articles/s41586-023-06618-z STUDY: Expanded T Lymphocytes in the Cerebrospinal Fluid of Multiple Sclerosis Patients are Specific for Epstein-Barr-Virus-Infected B Cells https://pnas.org/doi/abs/10.1073/pnas.2315857121 Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 333 Guest: Dr. Luis Manrique-Trujillo Privacy Policy

December Specials - https://www.sarahkleinerwellness.com/holiday Free resources- https://www.sarahkleinerwellness.com/all-free-resources Do you want to find relief from pain without relying on medication? Dr. Mauro Zappaterra will be revealing the key to achieving a pain-free life through holistic methods. Discover how to manage your pain without the use of medication and regain control over your health and well-being. Join us for an eye-opening discussion on the power of cerebrospinal fluid in pain management. In this episode, you will be able to: Discover natural approaches to holistic pain management. Learn effective strategies for non-medication chronic pain relief. Uncover the vital role of cerebrospinal fluid in maintaining health. Explore the powerful impact of resonance on overall well-being. Understand how functional neurology can alter pain perception for the better. My special guest is Dr. Mauro Zappaterra. Dr. Mauro Zappaterra is a Harvard MD, PHD graduate with a passion for holistic healing and non-medication pain management. His journey into the study of cerebrospinal fluid and its impact on overall health has led him to incorporate hands-on healing modalities, diet, nutrition, movement, and mindfulness into his practice in Pasadena, California. With a strong background in medical research and a deep interest in the energetic aspects of health, Dr. Zappaterra brings a unique and well-rounded perspective to the discussion on pain management without medication. His extensive knowledge and experience make him a valuable resource for understanding the role of cerebrospinal fluid in promoting overall well-being and managing pain. The key moments in this episode are:00:00:00 - Managing Pain Without Drugs 00:03:03 - Dr. Zappaterra's Background and Holistic Training 00:10:17 - Discovering the Cerebrospinal Fluid 00:12:52 - Researching the Cerebrospinal Fluid 00:14:39 - Scientific and Holistic Approach to Studying the Fluid 00:15:34 - Introduction and Pain Management 00:17:25 - Personal Experience with Pain Management 00:19:01 - Reiki and Energy Healing 00:22:38 - Cerebrospinal Fluid and Water in the Body 00:28:51 - Transmission of Information through Fluid Resonance 00:33:32 - Illuminated Enlightenment and Energy Modalities 00:35:51 - Water, Health, and Resonance 00:39:09 - Challenging Research Responses 00:41:34 - Resonance Effect on Health 00:47:21 - Trusting the Innate Knowing 00:50:29 - The Power of Alternative Therapies 00:52:10 - Rethinking Evidence-Based Medicine 00:53:32 - The Role of Mindfulness and Meditation 01:00:18 - Understanding the Brain's Response to Chronic Pain 01:05:55 - Exploring Novel Approaches to Chronic Pain 01:07:01 - The Benefits of Mind-Body Practices 01:08:44 - Functional Neurology and Healing 01:10:17 - Conscious Imagination and Healing 01:13:38 - Research and Hope for Health 01:15:06 - Children's Books and Mindfulness Education 01:22:57 - Introduction and Book Promotion 01:23:42 - Gratitude and Conclusion 01:23:49 - Key Takeaways 01:24:18 - New Year Reflection ____________________________________________ This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional! ________________________________________ Get all my free guides and product recommendations to get started on your journey! https://www.sarahkleinerwellness.com/all-free-resources Use code YOGI for a discount on Blue Blockers at vivarays.com/carnivoreyogi Use code YOGI or YOGI12 for a discount at www.upgradedformulas.com Check out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) - https://sarah-kleiner.mykajabi.com/store Sign up for my newsletter to get special offers in the future! - https://sarah-kleiner.mykajabi.com/contact

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Mauro Zappaterra obtained his MD and PhD degrees from Harvard Medical School. He completed his PhD doing work with neuronal stem cells and the effects of the cerebrospinal fluid (CSF) in brain development and in the adult. He is published in numerous scientific articles on the CSF and his work was chosen as the cover image for the prestigious Neuron Journal. He was also featured in the New England Journal of Medicine in teaching medical students about living with life threatening diseases and in Psychology Today on an article titled “Joy: The art of loving life.” You can view the video version of this talk on SAND's website: An upcoming course with Mauro presented by SAND: The Wisdom of Pain: an online course live with Mauro Zappaterra. In this course we will: Explore the definition of pain, and the difference between pain and nociception. Apply this understanding to developing strategies to better cope with chronic pain. Examine the difference between acute pain and chronic pain, the importance of acute pain for survival, and the phenomenon of chronic pain. Discuss phantom limb pain and complex regional pain syndrome. Survey the evolution of treatment strategies that help people live more fully with these types of pain. Mauro Zappaterra's website: HoldingSpace.com Episode Topics: 0:00 – Introduction 4:36 – Meeting Mauro 9:14 – Connection to the Source 15:46 – Third Ventricle 18:18 – Where does this fluid come from? 22:22 – Our Ancestral CSF in the Sea 25:58 – Cleaning the Brain 32:06 – Water and Veda Austin 33:24 – De. Deep and NADI 38:38 – Movement and Light 43:34 – Breathwork and DMT 51:51 – Yogananda 53:14 – CSF and Energy

  Have you ever considered the wondrous role of cerebrospinal fluid (CSF) in your body? The CSF is a clear fluid that bathes our central nervous (CNS) system. Our CNS is entirely buoyant in this fluid. The CSF has many important functions in nervous system development and the adult human to promote growth and help maintain homeostasis. Research has shown that activating the parasympathetic nervous system helps drive the CSF into the nervous system tissue. If the CSF has evolved as a fluid system transmitting information, whether through mechanical means, vibrations, or light, could the CSF be responsible for transmitting source energy through our nervous system and body? Join me for a fascinating conversation with Dr. Zappaterra as we discuss: The evolution of CSF as a light-infused information conduitThe potential memory-holding power of CSF's watery essenceBridging the gap between metaphysical and physical through CSFExploring the idea of CSF as a luminous consciousness batteryEmbracing conscious breathwork to amplify your inner lightAnd so much more! Check out Dr. Zappaterra's website at HoldingSpace.com, along with his amazing children's books like "I Am," "All One," and "All Love," as well as the imaginative "Close Your Eyes, What Do You See?" co-authored with his insightful 7-year-old son.

Mauro Zappaterra obtained his MD and PhD degrees from Harvard Medical School. He completed his PhD doing work with neuronal stem cells and the effects of the cerebrospinal fluid (CSF) in brain development and in the adult. He is published in numerous scientific articles on the CSF and his work was chosen as the cover image for the prestigious Neuron Journal.  He was also featured in the New England Journal of Medicine in teaching medical students about living with life threatening diseases and in Psychology Today on an article titled “Joy: The art of loving life.” Holdingspace.com Watch in full here: https://evolvenetwork.tv/channel/dr-mauro-zappaterra Due to extreme censorship and shadow banning, we have created a platform challenging the mainstream paradigm, to create a space to share vision and views, to create long term sustainable health solutions. To express without censorship and restriction. To allow freedom of speech and interest in ideas that will allow humanity to Evolve… Become part of the solution. We hope you've enjoyed this podcast - if you'd like to listen to more, please visit the Evolve Network www.evolvenetwork.tv I'd love to know your thoughts and experiences - join the conversation on my Instagram @evolvenetworktv instagram.com/evolvenetworktv Facebook Page - www.facebook.com/evolvenetworktv Follow Pete Evans Telegram & other accounts here campsite.bio/peteevans

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.20.549937v1?rss=1 Authors: Kim, D., Gan, Y., Nedergaard, M., Kelley, D. H., Tithof, J. Abstract: Over the last decade, there has been a tremendously increased interest in understanding the neurophysiology of cerebrospinal fluid (CSF) flow, which plays a crucial role in clearing metabolic waste from the brain. This growing interest was largely initiated by two significant discoveries: the glymphatic system (a pathway for solute exchange between interstitial fluid deep within the brain and the CSF surrounding the brain) and meningeal lymphatic vessels (lymphatic vessels in the layer of tissue surrounding the brain that drain CSF). These two CSF systems work in unison, and their disruption has been implicated in several neurological disorders including Alzheimer's disease, stoke, and traumatic brain injury. Here, we present experimental techniques for in vivo quantification of CSF flow via direct imaging of fluorescent microspheres injected into the CSF. We discuss detailed image processing methods, including registration and masking of stagnant particles, to improve the quality of measurements. We provide guidance for quantifying CSF flow through particle tracking and offer tips for optimizing the process. Additionally, we describe techniques for measuring changes in arterial diameter, which is an hypothesized CSF pumping mechanism. Finally, we outline how these same techniques can be applied to cervical lymphatic vessels, which collect fluid downstream from meningeal lymphatic vessels. We anticipate that these fluid mechanical techniques will prove valuable for future quantitative studies aimed at understanding mechanisms of CSF transport and disruption, as well as for other complex biophysical systems. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.11.548482v1?rss=1 Authors: Jukkola, J., Kaakinen, M., Singh, A., Moradi, S., Ferdinando, H., Myllyla, T., Kiviniemi, V., Eklund, L. Abstract: Abstract Background Inside the incompressible cranium, the volume of cerebrospinal fluid (CSF) is directly linked to blood volume: a change in either will induce a compensatory change in the other. Vasodilatory lowering of blood pressure has been shown to result in an increase of intracranial pressure, which, in normal circumstances should return to equilibrium by increased fluid efflux. In this study, we investigated the effect of blood pressure lowering (BPL) on fluorescent CSF tracer absorption into the systemic blood circulation. Methods BPL was performed by an i.v. administration of nitric oxide donor sodium nitroprusside (5 g kg-1 min-1) or the Ca2+-channel blocker nicardipine hydrochloride (0.5 g kg-1 min-1) for 10 and 15 to 40 mins, respectively. The effect of BPL on CSF clearance was investigated by measuring the efflux of fluorescent tracers (40 kDa FITC-dextran, 45 kDa Texas Red-conjugated ovalbumin) into blood and deep cervical lymph nodes. Results Nicardipine and sodium nitroprusside reduced blood pressure by 32.0 {+/-} 19.6% and 22.0 {+/-} 2.5%, while temporarily elevating in intracranial pressure by 14.0 {+/-} 6.0% and 11.6 {+/-} 2.0%, respectively. BPL significantly increased tracer accumulation into deep cervical lymph nodes and systemic circulation, but reduced perivascular inflow along penetrating arteries in the brain. The enhanced tracer efflux by BPL into the systemic circulation was markedly reduced (-66.7%) by ligation of lymphatic vessels draining into deep cervical lymph nodes. Conclusions This is the first study showing that CSF clearance can be improved with acute hypotensive treatment and that the effect of the treatment is reduced by ligation of a lymphatic drainage pathway. Enhanced CSF clearance by BPL may have therapeutic potential in diseases with dysregulated CSF flow. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this edition of Null and Noteworthy, researchers upend early interventions and diagnostic boundaries.

In this edition of Null and Noteworthy, researchers upend early interventions and diagnostic boundaries.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.13.536674v1?rss=1 Authors: Zimmermann, J., Boudriot, C., Eipert, C., Hoffmann, G., Nuttall, R., Schneider, S., Schmitzer, L., Kufer, J., Kaczmarz, S., Hedderich, D., Ranft, A., Golkowski, D., Priller, J., Zimmer, C., Ilg, R., Schneider, G., Preibisch, C., Sorg, C., Zott, B. Abstract: Directed motion of cerebrospinal fluid (CSF flux) is instrumental for removing waste products from the brain. Fluctuations in global cerebral blood volume (CBV), induced by concerted changes of brain-wide neuronal activity, are suggested to drive CSF-flux. To test this hypothesis, we performed two related experiments in healthy humans, namely electro-encephalography and blood oxygenation level-dependent functional-MRI during burst-suppression anesthesia, and arterial spin labeling and functional-MRI during transient hypercapnia challenges. Changes in total CBV, induced by changes in instantaneous global neuronal activity during burst-suppression or brain blood flow during hyper-normocapnia transitions, cause opposite functional-MRI signal changes in the basal cisternae, marking CSF flux from and into the brain. This direct coupling of global neuronal activity, brain blood volume and CSF flux indicates a mechanism to enhance brain waste clearance. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.14.532581v1?rss=1 Authors: Steffensen, A. B., Edelbo, B. L., Barbuskaite, D., Andreassen, S. N., Olsen, M. H., Moeller, K., MacAulay, N. Abstract: It is crucial to maintain the intracranial pressure (ICP) within the physiological range to ensure proper brain function. The ICP may fluctuate during the light-dark phase cycle, complicating diagnosis and treatment choice in patients with pressure-related disorders. Such ICP fluctuations may originate in circadian or sleep-wake cycle-mediated modulation of cerebrospinal fluid (CSF) flow dynamics, which in addition could support diurnal regulation of brain waste clearance. Through a combination of patient data and in vivo telemetric pressure measurements in adult male rats, we demonstrated that ICP increases in the dark phase in both species, independently of vascular parameters. This increase aligns with elevated CSF collection in patients and CSF production rate in rats, the latter obtained with the ventriculo-cisternal perfusion assay. The dark-phase increase in CSF secretion in rats was, in part, assigned to increased transport activity of the choroid plexus Na+,K+,2Cl- cotransporter (NKCC1), which is implicated in CSF secretion by this tissue. In conclusion, CSF secretion, and thus ICP, increases in the dark phase in humans and rats, irrespective of their diurnal/nocturnal activity preference, in part due to altered choroid plexus transport activity. Our findings suggest that CSF dynamics are modulated by the circadian rhythm, rather than merely sleep itself. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

After an almost 2 1/2 year hiatus, the return episode covers the basics of the meninges and cerebrospinal fluid of the central nervous system.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.09.527912v1?rss=1 Authors: Zhou, L., Li, Y., Sweeney, E. M., Wang, X. H., Kuceyeski, A., Chang, G. C., Wang, Y., Ivanidze, J., Gauthier, S. A., de Leon, M. J., Nguyen, T. D. Abstract: Background and Purpose: Our objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20-80 years to study the effect of aging on the parenchymal cerebrospinal fluid fraction (CSFF), a measure of the microscopic-scale CSF space. Materials and Methods: A total of 66 volunteers (age range, 22-80 years) were enrolled. Voxel-wise maps of short-T2 myelin water fraction (MWF), intermediate-T2 intra/extra-cellular water fraction (IEWF), and long-T2 CSFF were obtained using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) sequence and three-pool non-linear least squares fitting. Multiple linear regression analysis with correction for multiple comparisons was performed to study the association between age and regional MWF, IEWF, and CSFF measurements, adjusting for sex and region of interest (ROI) volume. The cerebral white matter (WM), cerebral cortex, and subcortical deep gray matter (GM) were considered as ROIs. In each model, a quadratic term for age was tested using an ANOVA test. A Spearman's correlation between the normalized lateral ventricle volume, a measure of organ-level CSF space, and the regional CSFF, a measure of tissue-level CSF space, was computed. Results: In the multiple regression analysis, we found a statistically significant quadratic relationship between age and regional CSFF for all three ROIs (all p-values less than 0.001). A statistically significant quadratic relationship with age was also found for MWF in the deep GM (p = 0.004) and IEWF in the cortex (p = 0.012). There was a statistically significant linear relationship between age and regional IEWF in the cerebral WM (p = 0.006) and deep GM (p = 0.002). In the univariate correlation analysis, the normalized lateral ventricle volume was found to correlate moderately with the regional CSFF measurement in the cerebral WM ({rho} = 0.43, p less than 0.001), cortex ({rho} = 0.43, p less than 0.001), and deep GM ({rho} = 0.49, p less than 0.001). Conclusion: Brain tissue water residing in different water compartments shows complex changing patterns with age. Parenchymal CSFF, a biomarker of microscopic-scale CSF-like water, shows a quadratic increase in both GM and WM, starting approximately at the age of 50. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.31.526446v1?rss=1 Authors: Wardman, J. H., Jensen, M. N., Andreassen, S. N., Styrishave, B., Wilhjelm, J. E., Sinclair, A. J., MacAulay, N. J. Abstract: Background: Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure (ICP), impaired vision, and headache. Most cases of IIH occur in obese women of childbearing age, though age, BMI, and female sex do not encompass all aspects of IIH pathophysiology. Systemic metabolic dysregulation has been identified in IIH with a profile of androgen excess. However, the mechanistic coupling between obesity/hormonal perturbations and cerebrospinal fluid dynamics remains unresolved. Methods: Female Wistar rats were either fed a high fat diet (HFD) or exposed to adjuvant testosterone treatment to recapitulate IIH causal drivers. Cerebrospinal fluid (CSF) and blood testosterone levels were determined with mass spectrometry, ICP and CSF dynamics with in vivo experimentation, and the choroid plexus function revealed with transcriptomics and ex vivo isotope-based flux assays. Results: HFD-fed rats presented with increased ICP, which was not accompanied by altered CSF dynamics or modified choroid plexus function. Chronic adjuvant testosterone treatment of lean rats caused elevated CSF secretion rate, in association with increased activity of the choroid plexus Na+,K+,2Cl- cotransporter, NKCC1. Conclusions: HFD-induced ICP elevation in experimental rats did not originate from an increased rate of CSF secretion. Such modulation of CSF dynamics only came about with adjuvant testosterone treatment, mimicking the androgen excess observed in female IIH patients. Obesity-induced androgen dysregulation may thus play a crucial role in the disease mechanism of IIH. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.24.525362v1?rss=1 Authors: Brown, J., Camporesi, E., Lantero-Rodriguez, J., Olsson, M., Wang, A., Medem, B., Zetterberg, H., Blennow, K., Wall, M. J., Karikari, T. K., Hill, E. Abstract: Alzheimer's disease (AD) is the leading cause of dementia worldwide. In AD animal models, soluble tau aggregates have been shown to disrupt neuronal function, alter synaptic plasticity and impair cognitive function. In humans, small fractions of these toxic tau species are secreted into cerebrospinal fluid (CSF), some of which can be measured as diagnostic and prognostic biomarkers, starting from early stages of disease. However, the mechanisms of how these tau forms alter neuronal and network function are not fully understood. Here, we have developed and applied a novel approach to examine the electrophysiological effects of CSF from patients with a tau-positive biomarker profile. The method involves incubation of acutely-isolated wild-type mouse hippocampal brain slices with small volumes of diluted human CSF, followed by a suite of electrophysiological recording methods to evaluate their effects on neuronal function from single cells through to the network level. Comparison of the toxicity profiles of the same CSF samples, with and without immuno-depletion for tau, has enabled a pioneering demonstration that CSF-tau potently modulates neuronal function. We demonstrate that CSF-tau mediates an increase in neuronal excitability in single cells. We then observed, at the network level, increased input-output responses and enhanced paired-pulse facilitation as well as an increase in long-term potentiation. Finally, we show that CSF-tau modifies the generation and maintenance of hippocampal theta oscillations, which have important roles in learning and memory and are known to be altered in AD patients. Together, we describe a novel method for screening human CSF-tau to understand functional effects on neuron and network activity, which could have far-reaching benefits in understanding tau pathology, thus allowing for the development of better targeted treatments for tauopathies in the future. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://psychiatry.dev/wp-content/uploads/speaker/post-11306.mp3?cb=1672149492.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment – PubMed Natalie Piehl et al. Cell. 2022. Cerebrospinal fluid (CSF)Full EntryCerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment – PubMed

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.14.520067v1?rss=1 Authors: RIONDEL, P., JURCIC, N., TROUSLARD, J., WANAVERBECQ, N., SEDDIK, R. Abstract: Spinal cerebrospinal fluid-contacting neurons (CSF-cNs) form an evolutionary conserved bipolar cells population localized around the central canal of all vertebrates. CSF-cNs were shown to express molecular markers of neuronal immaturity into adulthood, however the functional relevance of their incomplete maturation remains unknown. Neuronal maturation is classically associated with the expression of the K+-Cl- cotransporter 2 (KCC2), allowing chloride (Cl-) extrusion and hyperpolarising GABA transmission. Here, we show no detectable expression of KCC2 in CSF-cNs of adult mouse spinal cord. Accordingly, lack of KCC2 expression results in low Cl- extrusion capacity in CSF-cNs under high Cl- load in whole-cell patch-clamp. Using cell-attached recordings, we found that activation of ionotropic GABAA receptors induced a dominant depolarising effect in 70% of CSF-cNs recorded with intact intracellular chloride concentration. Moreover, in these cells, depolarising GABA-responses can drive action potentials as well as intracellular calcium elevations by activating voltage-gated calcium channels. CSF-cNs express the Na+-K+-Cl- cotransporter 1 (NKCC1) involved in Cl- uptake and its inhibition by bumetanide blocked the GABA-induced calcium transients in CSF-cNs. Finally, we show that activation of metabotropic GABAB receptors did not mediate hyperpolarisation in spinal CSF-cNs, presumably due to the lack of expression of G protein-coupled inwardly rectifying potassium (GIRK) channels. Together, these findings outline CSF-cNs as a unique neuronal population in adult spinal cord with immature Cl- homeostasis and no hyperpolarising GABAergic signalling but rather generation of excitation and intracellular calcium modulation. GABA may therefore promote CSF-cNs maturation and integration into the existing spinal circuit. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.07.519393v1?rss=1 Authors: Modeste, E. S., Ping, L., Watson, C. M., Duong, D. M., Dammer, E. B., Johnson, E. C. B., Roberts, B. R., Lah, J. J., Levey, A. I., Seyfried, N. T. Abstract: Despite being twice as likely to get Alzheimers disease (AD), African Americans have been grossly underrepresented in AD research. While emerging evidence indicates that African Americans with AD have lower cerebrospinal fluid (CSF) levels of Tau compared to Caucasians, other differences in AD CSF biomarkers have not been fully elucidated. Here, we performed unbiased proteomic profiling of CSF from African Americans and Caucasians with and without AD to identify both common and divergent AD CSF biomarkers. Multiplex tandem mass tag-based mass spectrometry (TMT-MS) quantified 1,840 proteins from 105 control and 98 AD patients of which 100 identified as Caucasian while 103 identified as African American. Consistent with previous findings, the increase of Tau levels in AD was greater in Caucasians than in African Americans by both immunoassay and TMT-MS measurements. Network analysis organized the CSF proteome into 14 modules associated with brain cell-types and biological pathways. CSF modules which included 14-3-3 proteins (YWHAZ and YWHAG), demonstrated equivalent disease-related elevations in both African Americans and Caucasians with AD, whereas other modules demonstrated more profound disease changes within race. Modules enriched with proteins involved with glycolysis and neuronal/cytoskeletal proteins, including Tau, were more increased in Caucasians than in African Americans with AD. In contrast, a module enriched with synaptic proteins including VGF, SCG2, and NPTX2 was significantly lower in African Americans than Caucasians with AD. Using a targeted proteomic approach (selected reaction monitoring) followed by a receiver operating characteristic curve (ROC) analysis we measured levels of VGF, SCG2, and NPTX2, which were significantly better at classifying African Americans than Caucasians with AD. Collectively, our findings provide insight into additional protein biomarkers and pathways reflecting underlying brain pathology that are shared or differ by race. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.03.515111v1?rss=1 Authors: Zhu, Y., Wang, G., Kolluru, C., Gu, Y., Gao, H., Zhang, J., Wang, Y., Wilson, D. L., Zhu, X., Flask, C. A., Yu, X. Abstract: Recent studies have suggested the glymphatic system as a solute transport pathway and waste removal mechanism in the brain. Imaging intracisternally administered tracers provides the opportunity of assessing various aspects of the glymphatic function in vivo. Dynamic contrast-enhanced MRI allows the evaluation of both the kinetics and spatial distribution of tracer transport throughout the brain. In this study, we investigated the impact of the molecular size of intracisternal tracers on the transport kinetics and distribution in the healthy mouse brain. Three MRI contrast agents with drastically different molecular weights (MWs): 1) Gd-DTPA (MW=661.8 Da), 2) GadoSpin (MW=200 kDa), and 3) oxygen-17 enriched water (H217O, MW=19 Da), were administered via cisterna magna infusion and their transport was dynamically assessed. Our results show that the transport of H217O was significantly faster and more extensive than the two gadolinium-based contrast agents. Time-lagged correlation analysis and clustering analysis comparing the kinetics of Gd-DTPA and H217O transport also showed different cluster patterns and lag time between different regions of the brain. Further, there were also significant differences in the transport kinetics of the three tracers to the lateral ventricles. These observations suggest the size-dependent differences in forces that drive tracer transport in the brain. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://psychiatry.dev/wp-content/uploads/speaker/post-10219.mp3?cb=1665082737.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Neurodegeneration Markers in the Cerebrospinal Fluid of 100 Patients with Schizophrenia Spectrum Disorder Kimon Runge et al. Schizophrenia Bulletin. 2022. Schizophrenia spectrumFull EntryNeurodegeneration Markers in the Cerebrospinal Fluid of 100 Patients with Schizophrenia Spectrum Disorder

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.30.510413v1?rss=1 Authors: Zou, Y., Han, J. R., Yang, Y., Wu, T. W., Shi, T.-T., Li, W. Abstract: Cerebrospinal fluid (CSF) is a clear fluid surrounding and nourishing the brain and spinal cord. Molecular profiling of the CSF is a common diagnostic approach for central nervous system (CNS) diseases, including infectious diseases, autoimmune disorders, brain hemorrhage and traumatic brain injury, CNS tumors, and Alzheimer's disease. Rodent models are critical for investigating CNS disease mechanisms and therapeutics, however, both collecting CSF and injecting materials into CSF in small animals are technically challenging and often result in high rates of postoperative mortality. Here, we present an easy-to-practice and cost-effective protocol with minimum instrument requirements to access the CSF in live rodents for collection and infusion purposes. By introducing a metal needle tool bent at a unique angle and length, we could steadily reach the CSF via the foramen magnum. Compared with prior methods, this protocol requires neither the operator to discern the changes in resistance from solid tissues while puncturing the needle, nor surgical opening of the skin and muscle covering the rodent neck. Using this method, we frequently obtain 5-15 L of CSF from mice and 70-120 L from rats to enable diverse downstream analyses including mass spectrometry. Due to the minimal invasiveness, this procedure allows iterative CSF collection from the same animal every few days - a major improvement over prior protocols that require extensive surgical operations. Moreover, we demonstrate that this method could be used for injecting desired solutions including dyes into mouse CSF with high success rates. Our method shortens the time required for CSF collection or injection to 3-5 minutes. Notably, we could reach near 100% postoperative recovery rates in both mice and rats even with repetitive collections. Together, we establish an efficient and minimally-invasive protocol for collecting CSF and inoculating reagents into the CSF in live rodents to enable various longitudinal studies at the forefronts of CNS investigation. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.14.506792v1?rss=1 Authors: Schutzer, S. E., Liu, T., Tsai, C.-F., Petyuk, V. A., Schepmoes, A., Wang, Y.-T., Weitz, K., Bergquist, J., Smith, R., Natelson, B. Abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms particularly disabling fatigue. This has given rise to the question whether they are distinct central nervous system (CNS) entities or is one an extension of the other. To investigate this, we used unbiased quantitative mass spectrometry-based proteomics to examine the most proximal fluid to the brain, cerebrospinal fluid (CSF). This was to ascertain if the proteome profile of one was the same or different from the other. We examined two separate groups of ME/CFS, one with (n=15) and one without (n=15) fibromyalgia. We quantified a total of 2,083 proteins using immunoaffinity depletion, tandem mass tag isobaric labeling and offline two-dimensional liquid chromatography coupled to tandem mass spectrometry, including 1,789 that were quantified in all the CSF samples. ANOVA analysis did not yield any proteins with an adjusted p-value less than 0.05. This supports the notion that ME/CFS and fibromyalgia as currently defined are not distinct entities Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

YOGIC BREATHING & CEREBROSPINAL FLUID: Cerebrospinal fluid flows through and around the brain and spinal cord to support the healthy function of the brain and nervous system. The reduction of CSF turnover may contribute to the accumulation of metabolites seen in aging and neurodegenerative diseases, such as Alzheimer's and dementia. CSF assists the brain by providing protection, nourishment, and waste removal. So, it's essential to optimize CSF flow. Recent research shows that this flow is enhanced by slow, deep, diaphragmatic breathing. Stephen and Kevin discuss and guide spinal breathing practice in yoga and Subtle Energy Meditation that supports optimal brain function and higher consciousness.For more information on Subtle Energy Meditation, including our upcoming 10-week SEM Course, ROV Meditation App, Raising Our Vibration book, and practice community, visit: https://raisingourvibration.net

Scientists at Stanford infused cerebrospinal fluid from young mice into older mice, and found that they could reverse memory loss. ThePrint's Sandhya Ramesh explains the science behind the new findings and why such treatments are still far away for humans. ----more---- https://theprint.in/health/wondering-why-your-child-suddenly-rebelled-at-13-stanford-study-on-teenage-brain-has-answer/943594/   

Dr. Diaz completes the lecture on Cerebrospinal Fluid.

(00:32) Before we get started, Dr. Willrich, can you give us a quick introduction of yourself and your role here at Mayo Clinic?(01:13) Can you give us a little bit of background about what kappa free light chain testing is and the importance of the multiple sclerosis test?(05:01) Can you give us a brief discussion about what this publication means and what it means to patients and physicians as a whole?(06:12) So when it comes to these methods, what should you tell physicians? You know, why we should use kappa free light chains other than those other methods?(08:39) When it comes to this new approach, can you tell me about how does this really impact the patients? (10:18) Thanks so much for that information, Dr. Willrich , can you tell me, what does this mean for the patients?(12:08) With you being one of the authors for this publication, can you tell me what this publication means to you and what it should mean to everyone else?

In this episode, we review the high-yield topic of Cerebrospinal Fluid (CSF) from the Neurology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbulletsIn this episode --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

Charge your Cerebrospinal Fluid | Charge your Neurons What makes your memory powerful? How do Yogic Locks help in charging the cerebrospinal fluid? www.BeingShiva.Org www.YogiParampara.org

In this podcast, John R. Samples, MD, and Russell Swan, MD, discuss the relevance of cerebrospinal fluid pressure in the management of glaucoma.

In this episode, Martin C. Mahoney, MD, PhD, discusses new data on vaccine-preventable diseases from IDWeek 2021, including:Pneumococcal diseaseRespiratory syncytial virus (RSV)Herpes zosterInfluenzaPresenter:Martin C. Mahoney, MD, PhD  Professor of OncologyDepartment of Internal MedicineRoswell Park Comprehensive    Cancer InstituteBuffalo, New York  Follow along with an expanded slideset at:https://bit.ly/3Ev8ozrLink to full program:https://bit.ly/3BCHF2E

Biocept Inc (NASDAQ:BIOC) CEO Mike Nall and CFO/COO Tim Kennedy joined Proactive to discuss implementation of its COVID-19 testing services at more than 30 community college campuses across California. On the oncology side, Nall says its cerebrospinal fluid assay CNSide had been shown to be able to detect markers of a complication of non-small cell lung cancer (NSCLC), which could mean targeted treatment that would allow patients' lives to be extended.

In this episode Jeremy has a conversation with Dr. Jon Lieff about his new book, The Secret Language of Cells.  Much of his work, as you'll hear in this conversation, is about where the mind exists.  We often equate the brain with the mind, but he's asking us to consider; why are these cells are communicating with one another; what information are they conveying, what processes are they initiating; and perhaps most profoundly, who is the director? https://jonlieffmd.com/https://www.patreon.com/highwaytohealthhttps://www.highwayto.healthhttp://www.jeremyquinbycst.comSupport the show (http://patreon.com/highwaytohealth)

Cerebrospinal fluid is the clear fluid that surrounds the brain and spinal cord. It cushions the brain and spinal cord from injury, delivers nutrients and acts as a waste removal system for the brain. A cerebrospinal fluid leak occurs when fluid escapes through a small tear or hole in the outermost layer of tissue that surrounds the brain or the spinal cord. Leaks can occur in the skull or at any point along the spinal column. Because headache is a common symptom, patients are often misdiagnosed or mistreated for migraines. "About 85% of patients with a cerebrospinal fluid leak at the level of the spine will have an orthostatic headache — one that gets worse when they stand up and better when they lie down," says Dr. Jeremy Cutsforth-Gregory, a Mayo Clinic neurologist. Once properly diagnosed, a blood patch procedure is often an effective treatment for spinal cerebrospinal fluid leaks. The patient's own blood is injected into the spinal canal, and the blood clot that forms can stop the leak. In other patients, surgery or a novel procedure called paraspinal vein embolization may be more appropriate. On the Mayo Clinic Q&A podcast, Dr. Cutsforth-Gregory discusses diagnosing and treating spinal cerebrospinal fluid leaks.  

I read from cerebrospinal fluid to ceremony.     The word of the episode is "ceremony".     dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar 917-727-5757

Anthony DePasqua, CEO of EnClear Therapies, sits down with Neil to discuss the company's technology in development to remove toxic proteins from cerebrospinal spinal fluid to treat patients with ALS and other neurodegenerative conditions.

In this VETgirl online veterinary CE podcast, we discuss cerebrospinal fluid (CSF) collection in dogs. In this podcast, we review a study entitled "Comparison of cerebellomedullary and lumbar cerebrospinal fluid analysis in dogs with neurological disease" by Lambe et al. In this study, the authors compared CSF samples collected from the CM and lumbar cisterns in dogs that were undergoing MRI and CSF collection for CNS disease.

Dr. Sharon Stills interviews Dr. Mauro Zappaterra who has entered an unconventional path leading him to discover dimensions of the vastly unexplored fluid within us called cerebrospinal fluid (CSF). Could this be the holy grail that connects us as humans to something greater than ourselves?