Podcasts about lorem

Roisin McGuigan, Commissioning Editor, Nucleic Acid Insights, speaks to Stanley Crooke, Chairman, Founder and CEO, n-Lorem, about his long career and pioneering role in the antisense oligonucleotide (ASO) space, how RNA-targeting therapies are set to enter the mainstream, and his latest focus: making personalized, free-for-life ASO therapies available to nano-rare patient populations.

La recherche utilisateurs, pour certaines équipes, c'est une étape obligée. Pour d'autres, ça fait grincer des dents : pas le temps, pas le budget, peur inconsciente d'être confronté à une idée contraire... La recherche, on la perçoit comme un travail compliqué, qui prend forcement beaucoup de temps. Alors, j'ai eu envie de démystifier, de désacraliser la recherche, en confrontant les pratiques de 3 personnes. Bien sûr, j'ai voulu me concentrer sur l'UX writing.Pour mettre l'accent sur l'importance de l'information, du langage et des émotions des utilisateurs, et sur l'importance pour une UX writer ou un Content designer de participer à cette phase de recherche. À mes côtés, j'ai pu compter sur : Alexandre Prot, UX researcher et UX writer chez LumApps Fatiha Belabed, Content designer chez Mews Camille Bourjade, Content designer freelance Ensemble, on a commencé par reposer les bases avec la définition de la recherche. Pour ensuite s'attaquer à plusieurs questions qui suscitent des débats : Pourquoi est-ce important de participer à la phase de recherche quand on fait du Content design ? Qu'apporte l'expertise UX writing à la recherche ? Comment se nourrissent ces 2 expertises ? Comment convaincre de faire de la recherche ? Est-ce qu'il est possible de tester uniquement le contenu écrit ? Si oui, comment ? Enfin, notre conversation est ponctuée de nombreux exemples de recherches menées, avec des pratiques souvent applicables simplement. Bonne écoute ! - L'épisode est aussi accessible en format écrit sur ⁠⁠⁠⁠⁠⁠le ⁠⁠blog⁠⁠ de Lorem UX writing⁠⁠⁠⁠⁠⁠. Vous y trouverez les ressources citées. Pour être au courant de la sortie des nouveaux épisodes, n'hésitez pas : à vous abonner, sur la plateforme d'écoute de votre choix à vous inscrire à la newsletter du même nom - ⁠⁠⁠⁠⁠⁠⁠⁠⁠UX Content Craft, by Lorem⁠⁠⁠⁠⁠⁠⁠⁠⁠, sur Substack ou à me suivre sur ⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠

Title  – Photophobia and diarrhea   Episode description RR discuss a fascinating case of fever, photophobia and diarrhea   Student discount https://www.rlrcpsolvers.com/student-discounts/   IMG discount Use coupon code RLRIMG at check out  https://rlrcpsolvers.com/annual-plan                   Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec… Read More »Episode 368 – RLR – Fever and photophobia

Opa, aqui é Gustavo Estrela, o AutoPeel, e hoje vamos dar uma primeira visão para um debate; Devemos criar a lore do personagem antes ou depois das fichas?Muitos jogadores costumam pensar seus personagens antes de fazer a ficha, deixando eles frustrados com as limitações que aquilo pode trazer quando coloca o personagem no papel. Hoje vamos falar sobre isso e dar argumentos para você criar o seu personagem depois de terminar a ficha. O Dicas de RPG é um podcast semanal no formato de pílula que todo domingo vai chegar no seu feed. Contudo precisamos da participação de vocês ouvintes para termos conteúdo para gravar. Ou seja, mande suas dúvidas que vamos respondê-las da melhor forma possível. Portanto pegue um lápis e o verso de uma ficha de personagem e anote as dicas que nossos mestres vão passar. Links: - Conheça nosso Patronato- Seja um Padrim do Movimento RPG- Assine o Picpay e ajude o site- Conheça mais Dicas clicando aqui. E-mail: contato@movimentorpg.com.br - Tem dúvidas sobre alguma coisa relacionado a RPG? Mande suas dúvidas para nosso e-mail. Voz:Gustavo Estrela, o AutoPeelEdição do Podcast: Senhor AArte da Capa: Raul Galli Crie sua Ficha Antes do seu LoreMúsicas: Music by from Pixabay

Il y a quelques mois, quand j'ai repris le podcast en mains, le premier épisode parlait de la collaboration entre Product manager, Product designer & UX writer. Souvenez-vous, c'était avec Fanny et Cassandra, toutes deux chez Qonto, et moi-même pour la casquette UX writing. Je voulais montrer comment le métier d'UX writer s'articulait avec deux expertises majeures du Produit et du Design. Et montrer que 1) la conception ne se fait pas et ne peut se faire seul, 2) l'UX writing apporte une valeur en plus et un regard différent. C'était à l'échelle d'une grosse équipe design et produit - Qonto. À l'époque, il y avait 20 UX writers dans l'équipe, presque le double de Product designers, et je ne comptais plus le nombre de Product managers. C'est une organisation à part, qui correspond à peu d'entreprises ou que peu d'entreprises souhaitent emprunter. Dix mois plus tard, j'ai eu envie de parler de nouveau de la collaboration, cette fois-ci entre Product designer et UX writer, et à une plus petite, mais vraiment plus petite échelle. Aujourd'hui, j'ai le plaisir d'échanger avec Gautier Zimmermann & Mathilde Chauvin, qui sont respectivement Lead Product & Design et UX writer chez Malo. La particularité ? Il y a un Product designer et une UX writer dans l'équipe design (accompagnés aussi d'une Brand designer). Une équipe restreinte. Et un ratio - presque - de 1 pour 1. L'organisation est donc, elle aussi, très spécifique. Une organisation qui m'a fait me questionner. Pourquoi Malo n'a pas suivi le chemin classique de recruter un nouveau Product designer pour faire évoluer l'équipe ? Pourquoi avoir plutôt décidé de miser sur l'UX writing ? Dans ce cadre, comment s'articule la collaboration entre Product design & Content design ? Et aussi, quels sont les apports mutuels qui enrichissent les compétences de l'un et de l'autre ? Comme d'habitude, je ne réponds pas à ces questions. Je vous laisse à ma conversation avec Gautier et Mathilde. Bonne écoute ! - L'épisode est aussi accessible en format écrit sur ⁠⁠⁠⁠⁠⁠le ⁠blog⁠ de Lorem UX writing⁠⁠⁠⁠⁠⁠. Vous y trouverez les ressources citées. Pour être au courant de la sortie des nouveaux épisodes, n'hésitez pas : à vous abonner, sur la plateforme d'écoute de votre choix à vous inscrire à la newsletter du même nom - ⁠⁠⁠⁠⁠⁠⁠⁠UX Content Craft, by Lorem⁠⁠⁠⁠⁠⁠⁠⁠, sur Substack ou à me suivre sur ⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠

On reprend le podcast avec un épisode un peu particulier. Un sujet qui tombe à pic en cette rentrée de septembre, au rythme effréné, comme chaque année

The knowledge we are gaining at n-Lorem has even more value than benefiting nano-rare patients and their families. These insights will enable scientists to discover new therapeutic targets for both common and rare diseases, fundamentally changing the way we approach health and disease.Survey – Patient Empowerment Program PodcastRegister for the 2024 Nano-rare Patient ColloquiumOn This Episode We Discuss:Two most common words in medicine: Health and DiseaseThe Scientific MethodThe Importance of Single VariablesOrthogonal ThinkingWe Are at a Unique Moment in Medical HistoryGenomicsAdvances in OmicsBiological Networks and AIFacile Collection, Maintenance, Growth and Differentiation in the LabAntisense Technology

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Paul Compton and his wife Andrea chose to start a family through adoption. Unknown to anyone, one of their adopted boys, Taeson, was the inheritor of DRPLA, a progressive brain disorder caused by a mutation in the ATN1 gene. Determined to find a treatment and advocate for their son and others with the disease, the Comptons established CureDRPLA. In early 2024, Taeson received his initial treatment with an ASO discovered and developed by n-Lorem. Paul discusses his family's journey and shares his observations of Taeson's progress since beginning treatment.In This Episode We Discuss:3:05 – Paul's origins in business and finance 4:32 - Investment banking is different than traditional banking 7:27 – Opposites attract – Meeting his wife, Andrea, and starting a family through adoption 10:06 – Paul's son, Tayson, has a progressive brain disorder known as DRPLA, which is caused by a mutation in the ATN1 gene; Discovering the idea of n-Lorem 16:03 – Tayson's journey to a diagnosis 23:00 – The deterioration of his abilities over the years 25:00 – The progress Paul has observed in his son since initial treatment Links:Take our survey and receive an n-Lorem Store coupon code Register for the 2024 Nano-rare Patient Colloquium / October 30-31, 2024Make Hope Possible with a donation

Mutations affecting ion channels are the most common cause of 'applications for treatment' submitted to n-Lorem. These channels regulate the passage of essential electrically charged ions, like sodium, potassium, calcium, and chloride, into cells. Alas, ion channels pose a significant challenge in the ASO discovery process, as there is little room for error due to the need for highly allele-selective ASOs to achieve success. Let's 'dive into the channel' and explore the complexities of treating patients with ion channel mutations.Recently a report on one of our patients with an ion channel mutation was published in Endpoints News highlighting the power of our technology for these disorders. Check it out by clicking the link below.Endpoints News (endpts.com) A teenager faced constant seizures. Could a drug developed just for him stop them?Podcast Awards - The People's ChoiceSurvey – Patient Empowerment Program PodcastRegister for the 2024 Nano-rare Patient ColloquiumOn This Episode We Discuss:Defining Ion Channels and IonsHealth, Homeostasis, and Biological BufferingMultiple forms of the same geneMultiple Isoforms of Gene Product from the same geneNetwork redundancyIon Channels are different

Konstantina Skourti-Stathaki leads the n-Lorem research team behind the design and discovery of ASOs. Nadina, as we at n-Lorem call her, has a passion for helping patients and an excitement for science that is contagious. She joins the Patient Empowerment Program podcast to discuss her day-to-day activities as n-Lorem's Director of ASO Design and Discovery, the ongoing research her team is conducting, and more!On This Episode We Discuss:Inspired to study biology at the University of CreteLeaving Greece to attend grad school at the University of OxfordAn internship led Nadina to the world of RNALeaving academia to impact livesLessons learned from experiencing drug discovery and developmentThe reason she joined n-LoremDay-to-day activities as Director of ASO Design and discoveryn-Lorem's internal research management committee to make key decisions regarding programsOngoing research at n-Lorem to enhance allele selectivityStan Crooke on why he pioneered antisense technology

We're recapping the 2023 Nano-rare Patient Colloquium in this special “Best of” episode. For the Colloquium, we gathered the nano-rare community under one single roof for a full day of presentations and panels with experts, partners, supporters, and patients. So, we are bringing some of the top moments directly to your speakers. Discover the origins and aspirations of n-Lorem and Columbia University's Silence ALS initiative, visualize the journey of a nano-rare patient with the help of an emotional story told by a loved one, and imagine a future where commercial drug discovery organizations can focus on the world's rarest diseases and more all in this one episode. To access the entire event, visit https://www.nlorem.org/nano-rare-patient-colloquium-2023/Register for the 2024 NRPC: https://www.nlorem.org/2024-nano-rare-patient-colloquium-registration-form/

Research physicians and their associated institutions are monumental to the mission of the n-Lorem Foundation and are truly transformational to the lives of the nano-rare patients they treat. Olivia Kim-McManus, M.D., was one of four physician panelists at our first Colloquium who participated in "A Physician's Perspective on n-Lorem and Nano-rare". Hear Olivia's outlook on nano-rare patients and how the support of an institution like UCSD Rady Children's Hospital makes all the difference.On This Episode We Discuss:1:55 When Dr. McManus became interested in pediatric neurology and epilepsy 4:00 What ion channels do and why they play a role in epilepsy 5:17 How often is epilepsy genetically caused? 6:52 Why Dr. McManus and Rady Children's Hospital choose to invest time and resources in helping nano-rare patients. 11:50 Bringing people together for a single forum at the Nano-rare Patient Colloquium inspires collaboration between groups 14:43 The importance of a network of treating physicians and institutions and sharing experiences and lessons learned 17:58 Interest within Rady Children's Hospital regarding nano-rare patient treatment and ASOs 21:45 A Physician's Perspective of Nano-rare and n-Lorem

Genetics can be intricate, no doubt. With millions of mutations present in every human, one might wonder why not everyone is impacted by pathogenic diseases. The Patient Empowerment Program aims to assist you in grasping the fundamental concepts of various mutations and how they function, paving the way for you to enhance your understanding of genetics. Delve into the diverse array of disease-causing mutations, their characteristics, and explore which mutations could potentially be addressed through ASO treatment in this concluding episode of Advanced Genetics.On This Episode We Discuss:The nature of a SNPPre-mature-m-RNA effectsIndels can disrupt the reading frameDefining Alleles, Homozygous, Heterozygous, and Compound HeterozygousThe difference between whole exome and genome sequencingHow we, at n-Lorem, decide which patients are amendable to ASO treatmentsHow we design ASOs to take advantage of different post-RNA binding mechanismsMechanisms: Non-allele selective RNAse H1, Allele-selective RNAse H1, and Splicing ASOs

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Dui vivamus arcu felis bibendum ut. Et ligula ullamcorper malesuada proin libero nunc. Consectetur purus ut faucibus pulvinar elementum integer enim neque. Pharetra pharetra massa massa ultricies. Elit sed vulputate mi sit amet mauris commodo!   Need more content?  Subscribe to ThreeABP on Patreon! for $2 a month and get access to bonus content exclusive to members.    Shoutout to Pixabay for providing sound effects! Check them out at https://pixabay.com/    

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Today we are talking about CI for Drupal modules, How it helps us build Drupal, and the ongoing work and improvements being made with guest Fran Garcia-Linares. We'll also cover Require on Publish as our module of the week. For show notes visit: www.talkingDrupal.com/441 Topics What does CI mean How do Drupal modules use CI When we talk about Drupal CI are we talking about the website itself or the CI that supports contributors What tools does Drupal use for CI How do maintainers interact with CI What changes have happened in the last year Speed improvements Drupal CI vs Gitlab CI Process to convert When is Drupal CI being shut down What improvements are coming If someone has an issue where do they get help Resources Gitlab templates module Gitlab CI Drupal Support ElasticSearch 8 [#3279558] | Drupal.org Slack channel for ci questions #gitlab DrupalCI and all patch testing will be turned off on July 1, 2024 | Drupal.org Testing a Drupal module | Basic module building tutorial: Lorem ipsum generator Gitlab CI getting started GitLab CI | Using GitLab to Contribute to Drupal WIP: Create a space to document how to customize each of the GitLab CI jobs [#3423238] | Drupal.org will generate https://project.pages.drupalcode.org/gitlab_templates/ We are pushing for a basic version to be fully live this week [Meta] Switching to Gitlab CI [#3424725] | Drupal.org Guests Fran Garcia-Linares - fjgarlin Hosts Nic Laflin - nLighteneddevelopment.com nicxvan John Picozzi - epam.com johnpicozzi Anna Mykhailova - kalamuna.com amykhailova MOTW Correspondent Martin Anderson-Clutz - mandclu Brief description: Have you ever wanted to have content fields that could be optional until a piece of content is published, or ready to be published? There's a module for that. Module name/project name: Require on Publish Brief history How old: created in Apr 2018 by Mike Priscella (mpriscella), though recent releases are by Mark Dorison (markdorison) of Chromatic Versions available: 8.x-1.10 Maintainership Actively maintained, latest release just over a month ago Security coverage Test coverage Number of open issues: 18, 8 of which are bugs Usage stats: 3,001 sites Module features and usage With this module enabled, form to configure fields for you content types will have a new checkbox labeled “Required on Publish” Check this new box instead of the normal “Required field” checkbox to have the field only required if the content is being published or already published Useful for publishing workflows where you want content creators to be able to quickly get started on content, but ensure that fields will be filled in before publishing Useful for fields that will optimize the content for SEO, social sharing, search, and so on

For n-Lorem's Chief Operating Officer, Sarah Glass, the mission of n-Lorem is personal. Her son Ethan was diagnosed with a nano-rare mutation. A geneticist by training, she joined n-Lorem to oversee and direct the organization's efforts to provide hope and potential help to those who need it most. It's more than just a job for her; she's powered by her son and the entire nano-rare community. 1:20 Sarah's background, early life, and scientific interests 7:20 Thinking about the patient experience while at a Contract Research Organization 8:43 Rare disease trails are relatively new 10:54 Sarah's son, Ethan, is a nano-rare patient 16:15 How long it took for Ethan to receive a diagnosis 21:35 Ethan's diagnosis and symptoms25:55 How Sarah heard about n-Lorem29:30 How does one come to terms with caring for a nano-rare child; How do parents continue looking for opportunities of hope when they may feel hopeless32:58 What Sarah has learned while at n-Lorem36:48 The biggest surprises Sarah has encountered during her journey at n-Lorem

Charissa Lipman joins n-Lorem founder and CEO, and host of the Patient Empowerment Program Podcast, Dr. Stan Crooke, in this question-and-answer episode to discuss additional questions asked during the 2023 Nano-rare Patient Colloquium. Charissa attended the inaugural Colloquium in October 2023 and brings the perspective of a patient family member, discussing her experiences and takeaways from the meeting. She is the mother of Ryker, a nano-rare n-Lorem patient with a CACNA1A genetic mutation. Stan and Charissa sit down to have a conversation and together address questions from the nano-rare community. Do you have a question you want to ask Stan Crooke? Email podcast@nlorem.org for a chance to be featured in a future episode. For general questions, email info@nlorem.org.In this episode we answer:08:25 As you are successful in discovering and developing individualized ASO for nano-rare patients, do you envision creating a library of ASOs that would be available to patients across the world?10:29 For disease organization/patient advocacy groups that have several patients with the same mutation, should they apply for treatment as a group or separately?13:16 Would an ASO developed for one patient work for another patient with a mutation in the same gene?14:29 What's a SNP?16:19 As a nano-rare family member, I have never been so inspired in an opening address as what was provided at the 2023 colloquium by Stan Crooke. Given the mission of n-Lorem, I don't understand how any researching neurologist (or any researcher in the space) would not want to be at the absolute forefront of what n-Lorem is doing. Why do you think there is such an obstacle to being a part of an organization that has for the first time an opportunity to move the needle in such a meaningful way?20:16 How would you describe the relationship between n-Lorem and the research physician, and what should patients expect from each side?23:44 What do you mean by an optimized ASO?24:59 Would you expect to see better results from ASO treatment in patients who are younger versus older?28:10 The FDA has certain designations for program review (Fast Track, Orphan, etc,), is there anything like that for nano-rare patients?29:35 I realize that there was significant work done in 2023 to streamline n-Lorem's operations. Which processes in the workflow do you believe can still be optimized to help streamline patient programs?31:35 Has there been a change in the amount of time it takes to process a patient and develop and ASO...

We're getting candid in our interview with Susannah Joffe. We're Getting Candid with Susannah Joffe about how she gained the confidence to become the most authentic version of herself, how growing up in Austin, Texas and moving to New York has shaped her artistry, and the importance of building a visual world around her music. Susannah Joffe's new EP dropped February 2nd and sees her blending elements of indie rock, lofi, and country songwriting. She's racked up millions of streams as an independent artist and has been featured on playlists like Spotify's Lorem, Undercurrents, and All New Indie. Listen to the full interview with Susannah Joffe on Name 3 Songs podcast and find a transcribed excerpt at name3songs.com. For more of Name 3 Songs, check out our podcast here and other interviews here. Enjoy this episode? Join our Patreon community or leave us a tip on PayPal!  Want to talk more? Find us  @name3songs | @sara_feigin | @jenna_million Learn more about your ad choices. Visit megaphone.fm/adchoices

Las inteligencias artificiales que generan resúmenes de podcast son bastante deficientes, pero como estamos tan ocupados desarrollando software para nuestros clientes, es lo que hay. Además, nadie lee estas cosas, así que podríamos poner toneladas de Lorem ipsums y nadie se daría cuenta.O sí. Si es el caso, hacédnoslo saber. Lo mismo tenemos un premio para vosotros/as.El caso es que el resumen automático de Auphonic nos regala esta auténtica cutrez.En resumen, el hablante principal reconoce el crecimiento inesperado de su empresa y la incertidumbre que enfrenta. Destaca la importancia de tomar oportunidades y contratar talento técnico, así como compartir los problemas y dudas con el equipo. A pesar de los desafíos, busca cambios y mejoras. Admite errores pasados y busca soluciones para adaptarse a los cambios del mercado. Destaca el enfoque en cuidar a los clientes y busca nuevas estrategias de crecimiento. Reconoce la presión de obtener un retorno de inversión, pero valora la transparencia. Agradece al invitado y promueve su producto.

The International Food & Beverage Technology Association (IFBTA) is a nonprofit trade association that promotes the use of technology within the global food and beverage industries with a specific focus on education, networking, certification, standards, research, and events, while aligning with other industry associations and groups in support of their technology related initiatives.Rob started his career as a restaurant manager for Bob's Big Boy and Marriott Hotels. In those roles, he was able to marry his love of operations and restaurants with technology.  Rob is seeing an increase in the use of robotics in back-of-house operations in restaurants, but fewer uses for food delivery to tables. At CES, Rob sees a sharp increase in electric vehicles as a trend and robotics for use in food preparation and fewer uses of VR.   QUOTES “The word ‘technology' is changing. It's evolving as a definition in hospitality, food service and retail and that's a very exciting thing to see.” (Rob) “Certain terms and technology become very popular over time. The way to know what's popular is to go to a trade show and look above the aisles at the signs. I look at what words are being used. Many years ago it was one-to-one marketing or big data.” (Rob) “I think the concept of drones may be more of a fad than a trend (in food service). I'm not so hot on drones for delivery, I am very hot on autonomous vehicles and even hotter now that I'm at CES. There is a whole room at CES with electric vehicles and half of those vehicles – probably more than half – are using autonomous driving.” (Rob)“I believe in robotics. I think we're going to see it more in the back of the house for food preparation. That's very clear here at CES with robotic baristas. There's going to be at the NRF Show next week a robotic pizza maker that's being used by Walmart. What we don't see is a ton of robots being used for delivery of food (in restaurants) to tableside.” (Rob)“I saw a company in Taiwan and they were doing simultaneous translation with earbuds. I've seen this before, but it always needed a phone. This one did not need that. So we're really getting to the point of Star Trek where you put the earbuds in and you're instantly having conversations with somebody and it's instantly being translated.” (Rob) “One of the two things I've noticed at CES between last year and this year is a whole pavilion on vehicles. Electric scooters, cars and farming equipment. The other thing I noticed is that the big companies that usually do CES have two booths. I see LG electronics, who I normally see in the main building doing video displays and phones, now has a separate booth in the automotive section where they're showing their cars.” (Rob)  “I believe you can't talk about technology. The best way is to show people technology and show them how it's being used.” (Rob)  TRANSCRIPT 00:01.96vigorbrandingHello everyone today's guest is ah a self-described techovvader and someone I've known for a long long time. A good friend. He's Rob Grimes and he's the founder and Ceo of the international food and beverage technology Association Rob also has other businesses. He's tied to he'll talk a little bit about that. And he's obviously not in his house unless he has a casino and slot machines in his house. He's in vegas so obviously ah, you're at the Ceo show welcome to the show Rob ah, let's hear a little bit about you. 00:31.18Robert GrimesThank you? Well listen? Yeah I'm in vegas and unfortunately since we're doing this on a webcam I can't tell you that what goes on in vegas stays in Vegas but I can tell you that I got elevators behind me I got a Starbucks over that way I got slot machines over that way and. 00:43.23vigorbrandingX. 00:50.50Robert GrimesFront desk over here and when I come out to vegas I still get up my normal time which is about four thirty in the morning East Coast so I was up early and so you just never know what you see coming in and out so I cannot be responsible for anybody getting out of that elevator or going in the elevator. But. 01:04.72vigorbrandingYeah, very cool. Well you know, depending on who comes out of the elevator with whom this might be the most watched podcast of all time. So I'm pretty excited about it. 01:07.52Robert GrimesAnyway, so that's why I am but I am here for CES. 01:15.90Robert GrimesSome while. 01:18.62vigorbrandingSo anyway I've heard I mean you you call yourself? ah a techno vader you want to talk a little bit about that. 01:25.67Robert GrimesSo I don't call myself that that's sort of a name that was given to me. Um, now I've been called a lot of things but I thought that was sort of interesting and I think it was a combination of putting technology and innovation which is what I spend most of my time looking At. Ah, but at the same time sort of the entrepreneurial side of helping Tech. You know to come Along. So I Just it sort of stuck so I used it and um, but anyway so it's really the combination I'm not really a highly technical person I can't program I can't do things like that. But. What I do do is I spend my time in technology trying to figure out and forecast where I think it's going to go and then certainly try to predict New Trends and sometimes see new companies which is actually why I'm out here at cs. 02:12.66vigorbrandingVery Cool. So I mean a little refresher for those who aren't familiar with the international food and beverage technology association and what you and your team do the Ifbta promotes the use of technology within the food and beverage industry considering the constant advances in technology I Mean. You and I do Trends presentations. We speak on Trends and what's going on in food and beverage and technology and it's just technology I mean just that's always a trend. It's always the topic I mean you know it's a massive undertaking.. How do you begin to focus on that objective. 02:46.10Robert GrimesWell, ah, gosh you know that's such a big that's such a big subject and it's a very large question so I have blinders on so my blinders focus on technology as it relates to the hospitality food service and retail industry so you can't look at it all. But. You know I'm very focused on how technology putting aside my own personal interest and my own personal things that I like to use and do besides that. Um you know I'm very focused on how technology might work within our industries. However. What I've learned recently and I got a feeling that maybe 2024 is the year that yours and my worlds actually collide or combined and I'll tell you why because the word technology is changing and so as I go see technology even here at Cs like today. There's a food tech zone. That's going to be about technology of food. How do you cook it what type of foods you have that is technology yet most people thought technology in my world was point-of-ale and Kios and drivethroughs and but it isn't and your world working in the cpg world working with a lot of food products. That is technology as well and how it's going to be prepared and where it's going to be served and so I think the interesting thing about is that technology is evolving as a definition in hospitality food service and retail and that's sort of a very exciting thing to see. 04:09.57vigorbrandingYeah I think there's no question I mean it's It's a part of everything we do and you know whether it's the the marketing and restaurant world or if it's in the Cpg world. It's just it's it's ah it's just a paramount to be on top of the changing. 04:19.35Robert GrimesBut I've enjoyed the trends that you put out every year and you put out that report and you're really talking about food trends that's something I have to study more now because as those trends are there how that food is delivered and where it's delivered and whether it's a fresh food bending machine which nobody ever thought that they could do that or something. You know all of a sudden what you're putting out in the trends in food I need to actually follow in the trends in technology and put those things together. 04:45.63vigorbrandingYeah, absolutely absolutely so like I've heard you say you're a restaurant manager first I think it's awesome because you worked at Bob's big boy. That's where it's all started and so you're seeing needs you you know? Obviously it was a long time ago and technology has just evolved so. Ah, how does that all tie into tech. How did you end up in tech from that start. 05:03.67Robert Grimesum um I always believe that you also puts people in the right place at the right time nobody expects to do what they do and when I talk to students today in hospitality schools and I tell them to do like a focus chart I tell them your focus chart can't be any more than a year or two out. Because your life could change you know based upon things happen. So I did start as a restaurant manager um actually Roy Rogers then Bob's big boy both owned by Marriott at the time and then Marriott hotels and then I got asked to do a systems project. And it was supposed to be like six months go to Marriott Headquarters I was working in in a Marriott hotel as a assistant restaurant manager in Washington and it was a six month deal come to come to corporate help us on a systems project. We need somebody who understands operations and then when you're done. We send you back and you get promoted to restaurant magic well without. Totally getting into my age or where I might have been at the time the world of the pc and I collided at Marriott headquarters and it came out and so you didn't have to be a programmer anymore to do technology and so I took over point of sale for Marriott globally some Pms and that's actually how I got started but. I was like the first one of corporate headquarters to have a mobile phone. It was in a bag it was a bag phone pretty funny ah but then I had to convince my boss to pay for it because you had to pay $3 a minute for airtime I told him I was going to use it for support. But anyway so I was able to marry 2 things together. 06:19.36vigorbrandingE. 06:34.16Robert GrimesMy love for operations and restaurants which I still am involved in and then the tech side of it. 06:40.49vigorbrandingVery cool, very cool and it's It's always neat how that all kind of comes together and you know I just got I was talking my daughter this morning I said hey look if you love what you do, You don't work a day in your life. So if you find things you're really passionate about you can bring them together and really kind of grow in that it's just ah, it's wonderful and we're We're very lucky for that. 06:52.97Robert GrimesPeople should always do things that they're passionate about. 06:57.55vigorbrandingYeah, no question and so you you said it you and I both end up speaking a lot of the same things on technology you technology mostly and me food and beverage Cpg and restaurant. But then as you said they come together. So The last couple of Trends Presentations I'm sure that you've talked about that I've talked about we talk about things like. Drone delivery and robots and restaurants and you know is there a day that pizza and and and Chinese food's going to be delivered by drone and you know some of the stuff sounds pie in the sky. But but really the way technology is moving. It necessarily is so yeah. 07:28.74Robert GrimesUm, was that a play on words pie in the sky. Yeah, good be pizza pie. Um. 07:30.66vigorbrandingThere you go there, you go Pi the pie. Maybe that should be a company our next company the pie pie in the sky and we'll do pie delivery. Ah, ah yeah, yeah. 07:41.35Robert GrimesYou know it's funny certain terms and technology become very popular over time and so what I tell people is the way to know what's popular is you go to a trade show and it can be an industry show. It can be a general one like cs and what I always do is I look above the aisles. And the aisles have signs and they point in different directions to zones or places you can go and I look to see what are the big words that are being used so many years ago it was 1 to 1 marketing or big data was a term out there. You know drones are so so drones and robotics are sort of interesting now. I'm really shocked. You didn't say the word ai because that is the term right now and I'm getting a little tired of it. But but that is the term right now. However, here's an interesting perspective for you about drones specifically I have said for years that I didn't think that drones were actually going to be the end all method of delivery. 08:18.93vigorbrandingYeah, oh yeah, yeah. 08:36.16Robert GrimesI think they were showy and I think that they were things that people tested and they showed the pizza coming up and dropping it. Do I think the drones will be used to deliver to remote places. Yes, as long as you can get the distance so that you can go ahead and control the drone. Yeah and as long as you can deal with. 08:36.74vigorbrandingThat's. 08:51.96Robert GrimesAir traffic control seriously and things like that that you have to deal with but their payload isn't heavy enough to carry really a lot of stuff and you're going to have food quality issues. Okay, where I really thought and you'll get the punchline on this in a second. What I really have always thought was going to be the method. Of delivering stuff was autonomous vehicles. Whether a vehicle is just a little bot that goes on a campus or whether it's a car that drives itself That's where I thought it was be so here I am at Cs Do you know that for the last 2 to 3 years at Cs putting aside Covid. That when I went to Cs. There was a whole section on drones. Interesting I haven't seen that section yet as a matter of fact, when we get off this podcast I'm going to look it up because I don't think they actually have it as a section right now now Robotics is clearly a section that's here. 09:30.80vigorbrandingHe. 09:44.59vigorbranding3 09:46.89Robert GrimesSo I think the concept of drones may have been more of a fad than a trend now. Do I think the drones are going to be big sure because anybody following current events knows the military uses the drones and that is usually how things get their funding so I'm not so hot on the drones for delivery I am very hot. On the autonomous vehicles even hotter now that I go to cs there is a whole room. Its ceos of electric vehicles and half of those electric vehicles that are there probably more than half are showing autonomous driving. 10:18.84vigorbrandingAnd he. 10:21.79Robert GrimesIncluding how to and equip in a current car but not only that they have smaller vehicles that are autonomous that can do it for delivery. That's the way I think that you know ah delivery is going to go through autonomous vehicles. Um and the drones are going to be out there and then you talk about robotics you know. I also believe in robotics I think that we're really going to see it more in the back of the house than the front of house to start for food preparation. That's very clear here at cs with robotic baristas. Ah there's going to be at the Nrf show next week a robotic pizza maker that is being used by Walmart but those are all back of the house. What you don't see is a ton of robots being used for delivery of food to tableside now United Airlines put it in their clubs. 10:58.16vigorbrandingExcuse me. 11:06.42vigorbrandingGive up. 11:09.97Robert GrimesBut it's mainly to be an assistant to somebody take away dirty dishes or bring something out. We're not seeing that kind of robotics yet we will. But I think that we will see robotics in the back. So those are 2 huge technologies. You know the autonomous and the robotics that I think you know will make a difference to us. 11:29.20vigorbrandingYeah, and then let's face it with ah you know talking to all the restaurants and chains out there I mean getting employees is a big deal. So ah, you know Necessities is a mother of invention the the back out as so the backend robotics ah is certainly important to to to help them with their business and keep their business rolling. So. 11:29.25Robert GrimesI. 11:38.40Robert GrimesIf. 11:47.14vigorbrandingI Think that's that's ah, it's a really good point that you make um so when it comes. 11:49.49Robert GrimesUm, well robotics allows us robotics allows us to also open up smaller form factor or self-operated things and I actually consider. Vending to be Robot ah robotics in a box or restaurant in a box that is robotics when they're preparing fresh food hamburgers and pizzas that are made fresh in a bending machine. Not not something you know, frozen and microwaved or whatever in there. So. 12:05.22vigorbrandingThe. 12:14.70Robert GrimesIt's not so much about solving the employee problem. It actually is a revenue generator for opening up new units. Um. 12:18.00vigorbrandingYeah, it makes a lot of sense. Well so we talk about back office or in front of house a back of house when it comes to restaurant tech I mean obviously there's there's front of house technology. There's the stuff that consumers see. There's the back of the house kitchen technology which one is growing faster. 12:29.19Robert GrimesTo change. 12:34.61vigorbrandingAnd and which one is more important. Do you think that the restaurants jump on board. 12:40.76Robert GrimesI think that people will adopt back of the house more and a lot of the technology is in the back of the house. Um, if you want to talk about employees. You know it's funny I saw somebody yesterday a company out of China out of Taiwan and they were doing simultaneous. Ah translation with earbuds now I've seen this before and I've covered this before but it always needed a phone that you had to go through the phone to the earbuds. This one did not need that so we're really getting to the point of like star trek or something where they put the earbuds in and you're just instantly talking you know conversation with somebody. It's instantly being translated. So I asked the guy you know what's your use case for this so half the people I talked to here at cs. They're all on the consumer side. They never thought about doing anything on the commercial side. So we start talking well he tells me that honey grow is using it in the kitchen. Why are they doing that because they have workers that don't speak english. 13:30.89vigorbrandingNo. 13:36.21Robert GrimesAnd so what they're doing is they're using in the kitchen to train and to do simultaneous now. That's the only one in the us that's doing it. They are doing it a ton of them over in China and other places so I see a lot of technology being used in the back of the house to help prepare foods. Ah, to do ventless cooking like sous vide cooking that's out there I see technology and how the screens and the orders and communicating with the staff in the back of the house being more efficient for doing runner systems and things the front of the house. The biggest technology change I see in the front end house besides having customers do their own ordering which is in certain things is really to do the handheld terminals you know for taking the order at tableside in the payment is almost if you think about it's almost like the biggest technology change there is but mostly changes in the back. 14:22.63vigorbrandingI mean it makes sense total sense so you know it's interesting. You're at Cs Restaurants Nations restaurant news predicts that and 2024 will be the year that restaurant tech industry shrinks as smaller tech startups either shut down or get bought by larger players. Ah, is that do you think that's a good thing I mean because I will say on this podcast I mean I can have ah I can have a a new tech concept every week because there's just so many of them out there just it's they're everywhere and I'm sure you're aggregating it. You're understanding. It. You're you're managing it. You're looking at it. So I'm sure you see the same things. Do you think it's good that that that industry shrinks. Um, what? what are your? What are your feelings there. 15:02.36Robert GrimesSo you know so as you know I have a podcast called accelerate and I've covered this issue a little bit when I talk about all in 1 systems versus best to breed and all in 1 is where you get everything from one company. Best to breed is where you focus on specific areas I think um. 15:13.66vigorbrandingE. 15:18.60Robert GrimesThe ifbta also has something called exchange and which is being released next week which has about 600 different vendors in it. You know, not not paid vendors just sort of listing I think what we're seeing is a lot of innovation but the innovation is very very focused innovation. Like it could be the the headsets or it could be the displays or it could be your payroll or training or point of sale or loyalty and so. 15:38.78vigorbrandingMean. 15:48.14Robert GrimesThere is consolidation when you have something that comes out of the blue that takes everybody by storm and the big guys sit there and they go oh. We missed the vote I will never forget an fs tech panel I did where one of the major vendors said. We missed the boat on online ordering there're now over 30 companies and this is years ago they said there's over 30 companies that are doing this now and they are basically point-of sale companies because they take payments and and they can do an order and they said we miss the boat. So what are they going to do they have to have online ordering so they go ahead and they they purchase and consolidate the companies. Sometimes it's a matter of 2 companies that come together that have very specific focused technologies and you have to put them together to make it work like 1 has this one has that and you put them together. So I think it's good. We're going to see a lot more innovation though I don't think we're going to see as much shrinkage and part of the reason for that is the hospitality schools. 16:29.70vigorbrandingUm. 16:38.30Robert GrimesAre now offering innovation and entrepreneurship as a course even Penn State where even Penn State's doing that. So um I think we're going to see more because software is a lot easier to develop than hardware and we're not hardware dependent anymore. 16:39.91vigorbrandingGreat. 16:51.84vigorbrandingIt would be interesting I mean what do you? What are you seeing at Cs I mean I know it's only been one day so far is there anything That's really standing out anything new that you want to talk about. 16:54.00Robert GrimesSo I don't know that I agree with that I hadn't heard that and I don't know that I agree with that. 17:05.16Robert GrimesYeah, the general observations is cs and I'm going to have to look for the statistics on this because I'm not exactly sure my impression right now is that cs is not as crowded as it has been number one in the past I know that wasn't your question but you know, but it also could be because Las Vegas opened up a huge new. 17:15.21vigorbrandingInteresting now. It's interesting. 17:24.42Robert GrimesConvention center is part of cs it's connected and I think they spread out more so one of the 2 things that I've noticed last year and this year is a whole pavilion on vehicles and and when I say vehicles every electric scooter car truck up to big deer. You know, big deer farming equipment is electrified. They have their own building which is amazing to me with all the ev that's in there and we're not talking about autonomous vehicles now we're talking about all of even even Amazon the other thing I noticed is the really big companies that traditionally do see yes, now have two booths. So. 17:50.40vigorbrandingWhile. 18:03.90Robert GrimesI see Lg electronics who I normally see in the main building doing video displays you know and phones now has a separate pavilion in the automotive place where they're showing their cars so that's 2 Yeah, the the expense is is amazing. So I see. 18:09.87vigorbrandingUm. 18:13.41vigorbrandingWow. 18:22.36Robert GrimesSo I think it could be because you have so much more space that it makes it look like it's not as crowded but I bet you when the stats come in. It's probably as crowded. Um I haven't gotten to the wearables area yet which I'm going to do today and there's actually a food tech area there and I'm also looking for what's in the home. 18:32.58vigorbrandingMe. 18:40.85Robert GrimesI'm a little bit surprised I haven't seen so much in the way of glasses right now in the past ah vr I went to the gaming area yesterday just to see what was there. Ah the vr and the glasses are not as widely spread as they were in the past I know that ah meta got a lot of play with the um. With the glasses that came out from raban early this year I don't view those as very functional because there's nothing on the screen. It's basically a gopro in a ah in a nice looking glass. So I'm looking forward to that so I was a little surprised. They didn't see much of that. Um, the health and wellness area I'm not seeing as many watches and things as I normally would see. Um, and the robotics I am seeing robotics here for sure. Um, there's a lot of robotics as they relate to showing mechanics of how they can start to become like a human so a robotic dog was very interesting I saw and several. Boost but you always look for those surprises that are here. But there's nothing so far that's jumped out at me except maybe what has been missing. 19:43.83vigorbrandingInteresting. Well you want to talk a little bit about the Ifbta I mean this is ah something near and dear to you I mean the talk about that a little bit. What so what? What is ibta going to get from this show. What are you hoping to do? what are your members like talk about that a little bit. 19:55.33Robert GrimesWell our members so you know the ifta the food but international food and beverage technology association Yo we have a number of different missions. We are not a lobbying organization. Although we work with many. 19:59.57vigorbrandingMcburn. 20:09.45Robert GrimesSo our mission is to promote food and beverage technology which at the beginning of this podcast. We talked about maybe having a change in definition. Um, expanding to promote it to provide education and networking for our members globally and so that means chapters that means education like our certification program. Ah, that means events we do at certain industry events where we bring people together who are interested in technology but it also means partnering with the industry owners so to speak the associations like Naqs for convenience stores the and nf for the and nra for restaurants. Ah, you know. Just ah, partnering with them the american hotel lodging association to help them to bring technology because they can't focus on all these areas. So that's our mission is education and networking of our members and in that we recognize that our members are really threefold. 1 is the individual of a small the medium or the independent. Which is you're going to find in every state then you have your mid-tierer and your enterprise which wants something different entirely and then um, you also have the supplier community and you have the other people that are sort of friends of the community that do things so we really have to fill a role for all of them. That are there. So my mission here at cs is everybody can't be everywhere although I saw a whole contingent of mcdond's Donald going by on a guided tour yesterday. So not everybody can do that so I see my role here and a couple other people here as being sort of eyes and ears to predict. What's going to happen. 21:37.80vigorbrandingIn. 21:40.91Robert GrimesOr what we should be looking at and then focus on bringing that to the companies at things like and Nrf or fste or Murrttech or the and nraio or or places like that. So that's you know that's really the role and the role I played but I will just point out 1 other thing to you that I believe that you can't. 21:53.20vigorbrandingAnd. 21:59.27Robert GrimesTalk about technology really the best way is to show people technology to show them how it's being used and coming up live on our website today tomorrow certainly by by Monday you know you're going to be able to actually talk to me on the website. But if you saw me at and nf next week I would be this standup hologram. You could talk to and I can answer questions for you as if I'm doing it right now which is a great way of doing it. So we're going to put that kind of technology to use on our own website and other technologies because we want to be able to show people realistically how it can be used without going cutting edge. We want to be or bleeding edge. 22:21.36vigorbrandingRight. 22:36.66Robert GrimesYou know we want to show them the realistic use of it. So that's really our world. Yeah. 22:38.38vigorbrandingYeah, you're trying to bring the the stuff that's way out there closer home So people can see the actual uses how they can imply it and everything else and that's brilliant I mean you bring a lot of wealth. 22:45.95Robert GrimesAnd I'm and I'm cheap like everybody else though I don't want to spend a fortune on it. So I want to work with technologies that exist. 22:51.93vigorbrandingAh, ah, very cool, very cool. Do you want to talk about your other businesses anything like that or is there anything else from ah what you're seeing at the show I mean you know as we close this out like what are some of the things you want to maybe mention. 23:01.56Robert GrimesYeah, so I mean I am involved in a lot of businesses I think I've sort of lost count over time. But personally I believe I've been involved in about 80 different businesses. But that includes multiple variations of the same business but in different geographies around the world. So you know I've never sold any hardware software ever. I've always been more of a services kind of person so today I still own a constrata which is a consulting company and a services company that does deployments for people acting as their internal staff. Never want to sell I don't run those day to day because i. Certainly don't want a conflict with the Ita which is totally impartial and open to all and everybody's equall in the ivta all the operators all the suppliers and then um, you know I spend some time on some other entrepreneurial ventures trying to help people. But again those swim lane the pacoty food service retail services in technology. 23:42.27vigorbrandingIs. 23:58.73Robert GrimesIf it's outside of those lanes I probably shouldn't be doing it. Um I am very excited about next week where we're going to have for the first time a food service innovation zone at the national retail federation show at the javit center that is a huge show is the whole Javit Center what I find fascinating every year is the book ends and I will do an article and I will do a podcast as I do every year called tail the two cities vegas is the first one with cs and rf is the second one which is retail and it's really all retail so you know, ah. 24:29.76vigorbrandingYou. 24:34.16Robert GrimesI spend my time just looking at these things whether it's constrata the ifbta or just my personal thing I will tell you 1 thing that sometimes when I talk to people. Yeah about what their preferences are in tech I always like to get a feel for it and so I'm still trying to figure out how I become that tech influencer so Samsung. Just give me 1 of their new tri screen phones that they still haven't brought out after showing it two years ago but they should just give it to me so I can go ahead and use it and just show it to people like how to use it. So that's the 1 thing I have yet to achieve. 24:56.24vigorbrandingYeah, yeah, you are kind of an old school influencer before influencers were cool. That's for sure. There's no question about that now. 25:08.74Robert GrimesFast. 25:11.19vigorbrandingSo now a couple personal things here. So talk about this polar plunge thing you do this every year. Why do you do it? how many how many years have you been doing this thing. 25:19.29Robert GrimesAh, 4 years so the polar bear plunge in Margate in on the jersey shore since I'm from Philadelphia I've had a house of Jersey Shore um I don't know it was just sort of an idea to run in and you run into the water you got to dive because you got to get. Over this year. It was like really cold. Normally it hasn't been so cold and it was really cold and you had to run out far enough. It wasn't deep enough to do the dive because the waves weren't coming in so I had to go out and I'm like coming out of my ankles and my sins are like just numb. But I've been doing it for 3 years maybe 4 and um. 25:52.11vigorbrandingAh, nice. 25:55.49Robert GrimesIt's like 3000 people they do it all over the jersey shore you could actually do one like at ten o'clock one at 111 at 121 at 1 but it was just something to do it just seemed like a good idea at the time. 26:03.31vigorbrandingyeah yeah I I too I go to the jersey shore and I don't even go in the water in July because it's still too cold. So I have no desire whatsoever to do that. But it sounds the same. 26:12.59Robert GrimesI Do want to point out to anybody listening this podcast. We don't go to the beach. We're going to the shore and I want to make sure you know that there is a beach at the shore but we go to the shore. 26:24.66vigorbrandingYep I totally get it. That's a Philly thing. So last question I asked this of everybody if you had 1 final meal. What would you eat and why. 26:34.96Robert GrimesUm, a final meal. Um, well I mean I'm a huge steak fan but that's like what every prisoner orders for their last meal right? So I'm not so sure I want to I want to be there Um, a final meal. 26:46.23vigorbrandingAh. 26:48.40Robert GrimesThat's like really ah a tough question I'm sure it would be something it would be something like a steak of some sort that was out there just because I just happen ah like steakhouses and St it might be a plant. It might be a plant. It might be a plant based one by the way over time I did have. 26:58.18vigorbrandingIs there a particular steakhouse that you love. 27:07.39Robert GrimesJust just a note I love having conversations with people so I had a conversation at a function last night with this guy who told me he went vegan and he asked me what I thought the future of vegan was and whether people would adopt it over time and my response to him was this is about tech and food tech I said hey listen who would have thought ten years ago you could go to a burger King and get a whopper that you might not know the difference between a beef flopper one made a plant. So my view over time is that steak that I'm eating and I understand that ah Leonardo Dicaprio invested in a company that's doing plant-based steak is they're working on that and over time. 27:30.74vigorbrandingE so. 27:39.44vigorbrandingHere. 27:44.42Robert GrimesThere may be no difference and I will be eating a steak and as long as the texture the taste. You know the satisfaction is the same we're going to forget that you know over time and so I don't know if it'll be a plant-based steak for my last meal or whether it would be you know, really good I Love independent steakhouses I have a favorite here The Golden seer. Ah. 27:53.90vigorbrandingUm. 28:02.38vigorbrandingOh yeah. 28:04.28Robert GrimesWhich is a friend you know that has that it started in 1958 he wasn't around then but it's great. But I just like the old time steakhouses. 28:12.91vigorbrandingVery cool, very cool Rob look. It's always ah fascinating. It's always a pleasure I always enjoy talking to you I really appreciate your time. Enjoy the rest of Cs and thank you. 28:22.63Robert GrimesWell no, it's the pleasure I know I see it several times during the year and it always turns out to be a good conversation. It's a lot of ideas and actually even this conversation today just gave me a few thoughts that I might want to take a look at so thank you for having me. 28:32.22vigorbrandingMe too me too me too. Absolutely thanks. Rob. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

For the return of the patient empowerment program podcast, we're recapping the 2023 Nano-rare Patient Colloquium in this special “Best of” episode. For the Colloquium, we gathered the nano-rare community under one single roof for a full day of presentations and panels with experts, partners, supporters, and patients. So, we are bringing some of the top moments directly to your speakers. Discover the origins and aspirations of n-Lorem and Columbia University's Silence ALS initiative, visualize the journey of a nano-rare patient with an emotional story told by a loved one, and imagine a future where commercial drug discovery organizations can focus on the world's rarest diseases and more all in this one episode. To access the entire event, click here.

Nano-rare diseases strip power from families and this often leads to hopelessness, anger, and dread. However, channeling these intense emotions to carefully navigate risk/benefit decisions is within one's control.n-Lorem is different than standard drug development settings. Every risk/benefit decision that n-Lorem makes is in the context of the individual patient's symptoms, status, and needs. While we cannot promise benefit, we can promise that we will do our very best in the creation of an optimal medicine.On This Episode We Discuss:Risk/benefit decisionsn-Lorem is differentWe cannot make promisesCommunicating about riskPerceptions concerning controlExposure and riskCompressionOmissionTimingOfficial positions affect our perceptionsAnchoring and communicating risk

Jeff Carroll, Ph.D., inherited a gene that will eventually lead to symptoms of Huntington's Disease. Alongside researching this debilitating disease as an Associate Professor of Neurology at the University of Washington, he's a Scientific Advisor for n-Lorem and member of the Access to Treatment Committee (ATTC) that helps screen and assess submitted patient applications.On This Episode We Discuss:2:45 Joining the Amy on a whim 4:30 Serving in Kosovo and Germany6:00 Learning that his mother was diagnosed with Huntington's disease (HD)10:25 Seeking information and diving into the world of Biology and HD14:52 Deciding to have children when there was a chance that they'd inherit the disease and utilizing preimplantation genetic diagnosis (PGD)18:30 Watching Ionis make initial progress on an ASO for Huntington's disease23:10 How Jeff became involved with n-Lorem27:30 Most important things Jeff has learned during his role at n-Lorem30:38 Helping people is motivating32:11 Nano-rare patients teach us a lot about science33:57 Jeff expects to receive an ASO treatment one day35:22 n-Lorem is on your side

Chip Wilson, the creator of Lululemon and SOLVE FSHD, stands as a pioneer, business innovator, philanthropist, and a person affected by a rare disease. His passion for fitness led him to build a successful career in designing athletic wear, but a diagnosis of Facioscapulohumeral Muscular Dystrophy (FSHD), a degenerative muscle condition, altered his active lifestyle.On This Episode We Discuss:0:46 Working on the Alaska Oil Pipeline as a 17-year-old4:30 Saving money young and becoming an entrepreneur7:05 Following trends and founding Lululemon8:36 Chip's initial dream and vision for Lululemon11:45 Combining Italian design ethics with quality western fabrics for an amazing Lulu product 14:20 The feeling of leaving the Lululemon Board of Directors 17:00 The takeaways from Joseph Heller's Catch 22 and Something Happened 24:15 Reading the top 100 biographies and admiring those with integrity 33:44 Using the culture of an organization and leadership as a strategic advantage 38:18 Facioscapulohumeral muscular dystrophy (FSHD) 40:05 Chip on losing muscle when exercise and movement is so necessary for his way of life 44:27 Climbing Mount Kilimanjaro with FSHD 46:58 Chip's advice to those suffering from rare diseases and their caregivers 49:24 What progress that has been made to find a treatment for FSHD 52:35 Why Chip and SOLVE FSHD donated to help fund the funded the laboratory at n-Lorem

In this episode of Syntax, Wes and Scott relate even more spooky listener submitted coding horrors including crypto copy paste, Big Brother bug, losing $50,000, 2,000 SMS, a $20,000 hour, and more. Show Notes 00:09 Velcome to Synax 01:09 Syntax Brought to you by Sentry 01:36 Stories are anonymous! 01:57 Crypto copy + paste 03:48 Big Brother Bug 07:00 One of 6 laptops that can fix npm 07:57 Auto-submitting payments 09:42 40,000 orders shipped and refunded 11:16 Dropping the analytics database 11:40 dev was actually production 12:40 Updating the DNS 13:40 Losing ~$50,000 15:30 Clearing 80 million records 16:21 Web chat DDoS 18:00 URL Shortener #$@%# Ontario's rejected licence plates for 2022 | CP24.com Boonta Vista: A “political” podcast for “smart” people 21:12 Sending an email to 20,000 users 21:42 Moving code to GitHub 23:32 “Lorem sale” 26:08 2,000 SMS messages 27:00 International shipment of kiosks 28:19 Crashing production Slow DB Queries | Sentry Documentation 31:01 Hitting customers credit card limit 32:01 Infinite redirect loop 32:53 My first commit 33:23 Augmented reality game prize mistakes 35:15 A $20,000 hour 35:57 Site went down for 3 days 37:42 Accidentally truncated the prod database 38:48 Off by one error 40:05 Exposing database credentials 42:08 Delete a temp directory on prod 44:51 SIIIIICK ××× PIIIICKS ××× ××× SIIIIICK ××× PIIIICKS ××× Scott: Race to the Summit Wes: 100LBS Strong Magnetic Hooks Shameless Plugs Scott: Sentry Wes: Wes Bos Tutorials Tweet us your tasty treats Scott's Instagram LevelUpTutorials Instagram Wes' Instagram Wes' Twitter Wes' Facebook Scott's Twitter Make sure to include @SyntaxFM in your tweets Wes Bos on Bluesky Scott on Bluesky Syntax on Bluesky

After a year of various traumas and Voncid's recent transgressions, several Order members have mandated appointments with Delia the Order psychologist Hosted on Acast. See acast.com/privacy for more information.

Dr. Daniel Curran leads Takeda's efforts to unlock innovation and deliver transformative medicines in a variety of rare-disease areas. Dan embraces learning from, collaborating with, and meeting members of the rare disease community in an effort to produce treatments that result in better health and a brighter future for rare.2:02 How rare disease is defined at Takeda4:10 Rare disease units at Takeda5:23 How Takeda economically justifies half of their pipeline being rare disease drugs9:06 The price of rare disease drugs is too high12:15 Why rare disease efforts are often associated with hematology14:57 What Dr. Curran enjoys about leading Takeda's rare genetics and hematology therapeutic unit16:42 Dr. Curran's professional journey20:50 Takeda's choice to support n-Lorem

As the first ever Nano-rare Patient Colloquium is just around the corner, we are flipping the script. Spectrum News' Brady Huggett interviews n-Lorem founder and CEO, Dr. Stan Crooke, and picks his mind to understand the inspiration behind the creation and want for this first of its kind nano-rare community event. Along with some background information on the highly anticipated Colloquium, Stan candidly conveys n-Lorem's hurdles and joys in its first four years of service.

The first Dog Haus opened in Pasadena, California in 2010. Since then, Dog Haus has expanded to include 91 locations throughout southern California. Dog Haus has garnered critical acclaim and national attention for its signature all beef Haus Dogs and handcrafted proprietary Haus Sausages, as well as its 100% genetically tested, humanely raised, hormone- and antibiotic-free Black Angus beef. Many start-up restaurants rely on a celebrity name to drive consumer interest, which calls into question the quality of the food and expertise of the celebrity when it comes to the offering. Consistency of quality is important. Some restaurant brands don't have standards – or don't clearly define the standards – which means different dining experiences between each location or even at the same location. QUOTES “Our advantage is the quality of the food. It's the product itself.” (Justin) “We are created by people who are very much into food. That's been our goal since day one.” (Justin) “Zeroing in on the quality of the product. That's not a different story. So many brands think their product is ‘the best.' What (Dog Haus provides) is reasons to believe why that's true.” (Joseph) “How do you get someone to pay $8 for a hot dog when Costco sells it for $1.50. That's a unique challenge for us. We do that with high quality ingredients. It's not just a hot dog and you know that when you see it.” (Justin) “Quality matters, especially on delivery.” (Justin) “(Some restaurants) make it as cheap as possible and maximize profitability, get the money and go. I think now more than ever, the delivery game has changed that. After I've paid for delivery fees and that (meal) comes back tasting like garbage, that's horrible.” (Joseph) TRANSCRIPT 00:00.00 vigorbranding Everyone and today I'm joined by Justin Bartek you probably remember our episode from early on in the fork tales days I had to have him back because so much has changed since then Justin won't you say hello and ah give us a little update on where you've been and where you are now. 00:16.68 Justin Bartek Yeah, man, it's good to see you Joseph as always in the past few months about five months ago now I joined doghouse worldwide which is a hot dog brand but we do smash burgers hot dogs, gourmet sausages breakfast burritos that are actually killing it. Um. And more so it's very exciting to be over here I've sort of been put in a position to help with those virtual brands that they have called the absolute brands. But I'm also you know there's always so much to do that I've been helping with my own connections and background to all across the organization. So. It's been great. 00:50.71 vigorbranding That's awesome. So um, for those don't remember you you used to be at the Ramen company Jinnya I Still go there. Still love their ramen. 00:56.60 Justin Bartek I'm correct. 00:58.38 vigorbranding Um, and as you said now you're in this new position. Jinnya is a brick and mortar. It's full service. Well it's actually fast casual technically there's counters service. You sit down, you're kind of waited on um, whereas doghouse and and especially the virtual brand world completely different. So how has this transition gone from you gone for you and. 01:04.90 Justin Bartek And. 01:18.23 vigorbranding And what are what are some of the biggest challenges in shifting from this company that you're at now from Virginia as well as the format shift. 01:27.51 Justin Bartek Yeah, sure, um, you know when I came here. It's it's kind of a great time to be here and that you know when the doghouse brand started it started in 2010 as well same as Virginia um, but they were they were kind of a fast casual brand. You know it wasn't really about the bar. Yeah, they had beer. They didn't have full liquor licenses at the time they didn't have the doghouse beer garden concept. It was just doghouse so that's kind of our legacy brand at this point and you could imagine ah ah a doghouse like that might be in in an old Taco Bell like the old school Taco Bell that you know from the seventy s that building though. That's where a doghouse could be now. Got doghouse beer gardens. They've got full liquor licenses. They've got patios. They've got games. They've got you know, just much more of a bar experience. So since I've been over here. We've been talking about how to make this brand more bar. Friendly. How do we make it better. How do we. Increase the happy hour. How do we put it in new drinks. How do we? you know like we're really going through that top to bottom and really you know have a beverage committee now we're working with our drink partners like Coca-cola but we're also looking at the alcohol brands and kind of trying to do some bigger things we're doing. Doing milkshakes which we're going to do some spiked ones coming up which is really cool. So like all these things are in development and we're sort of that brand that's known for really like if we get an idea. Maybe we'll make a virtual brand out of it. Maybe we'll put it on our menu. You know we'll see but like they've been doing that over time and it's led to a lot of success. 02:50.65 vigorbranding That's awesome. Yeah, so I mean it's a completely different format even within doghouse. It sounds like you guys are really ah, evolving and iterating and learning. Um, what's interesting to me is this more immersive experience that you're talking about with the ah beer garden. It's nothing new, but. 02:53.54 Justin Bartek Um, yeah. 03:06.83 Justin Bartek Your. 03:08.66 vigorbranding Shifting from the traditional idea and bringing this in but then thinking about doghouses building this this. Um you know fame around that experience but virtual doesn't offer it So How are you bridging that gap. How do you bring that fun and that immersiveness and that uniqueness that doghouse has into these virtual brands that. Maybe inextricably linked ah for people For example. 03:30.41 Justin Bartek Um, yeah, it's funny. We've got these quirky names like badass breakfast burritos for instance or jail bird which is our wings um just different ideas like that. But what? what? I found what it really comes down to and I don't want to talk negative about any competitors but you know what it is. It's like. Got these brands that might have a celebrity at the Helm or just their name is slapped on it. The food quality is not there people know right away what we've seen. We've done a ton of research on this and really the last six months, especially but. The idea that you know Mr. Biesberger has 800 locations 3000 locations. Whatever that number they want to put on there but how many reorders are they getting after you order that 1 time how many people order that again I would say it's very small. The other thing we have going for us. You know in our like our badass breakfast burrito concept. We we average selling you know hundreds a day of that product right? So it's like that's per location. Mr. Beast we found only sells seven per day at the locations that they have so even though it's a huge volume because there's 3000 of them or whatever that number is they're not selling a ton. You know per location. So what we found is that our advantage is really the quality of the food and we we really try to push that in the forefront from the operations angle from packaging from you know, getting it to a science where we know this is what sells what's good. We know how to make it. We know how to deliver it with our partners or you know even taking that. 04:54.36 Justin Bartek Into direct delivery and that sort of thing so that's the that's the future. But what we what our advantages is the product itself and our food really sells itself like we're getting tons of repeat orders. We've got a great loyalty um to the brand and infinity to the brand. So now. Our next challenge is like how do we make. That doghouse fan know about badass breakfast burritos because it is not inside the 4 walls right? It's not on the menu board is badass breakfast breeze ah jail bird is not on the menu right? It's all virtual. So that's that's our challenge is like how do we connect them or maybe do we not want to connect them right? like maybe we don't need to connect them. Maybe we can license. Badass breakfast burritos with another bigger concept and they can sell that right? So like there's all these ideas out there that we're working on so there's a lot of excitement but really I think what it's come down to is the core products and how they travel and. This badass breakfast burritos I mean it's just it's doing so well, it's 20% of our sales now across the branch. So. It's just really taken off in ah in a huge way. So for my job. It's like how do I what I want to do is make badass breakfast bur briritos and or doghouse what you think of when you think of a breakfast burrito and I know that's hard to do in California but. In Maryland maybe it's easier right? Maybe it's easier in Atlanta you know, like just these other places where breakfast brito culture is not what it is I feel like we can really plant the flag and be that because this product tastes so good and it's really working. So. 06:05.49 vigorbranding Um. 06:16.30 vigorbranding Yeah, that's so much to unpack there. Um, so for clarity purposes the the virtual concepts that you have now solely exist within dog house footprints or do you have them for other ah Kitchens and. 06:25.20 Justin Bartek We? Yes, so we do work with both the main kitchen. So kitchen united is obviously our close partner but we do work with with the others as well in certain instances. You know what I mean but it's very limited and what we've what we've really found. Is we this year. We've sort of. Taken a step back from those so like the kitchen experience the virtual kitchens and really dove more into our own brick and mortar and how to make the execution better from our own stores and so even though we have 6 virtual brands. It's not like we're out here trying to get ghost kitchens for all of them. We're trying to run them from our own kitchens. 06:52.30 vigorbranding Um. 07:03.35 Justin Bartek And that's been sort of the focus for this year but what's great about that is like I said we could turn on a new brand tomorrow and then here's ah, here's another brand here's a different take on it. You know we're always the the real research in the kitchen is what. Is great here because these guys love to cook. They love food and it's like they're always inventive with that. So it's like it's it's a nice feeling to know they're also not scared to say okay, here's a brand like all we need is a logo It's a packaging and we we got the same ingredients for the most part usually so it's um, you know. 07:29.17 vigorbranding Um. 07:30.38 Justin Bartek They're They're very adventurous when it comes to that and then if one sticks great if doesn't we can take it away. You know it's not a lot of not a huge investment. 07:37.27 vigorbranding Yeah,, that's one of the things that I think has been um I don't I mean I'll say scary but I don't mean scary I think so in y'all's case it makes a lot of sense you have footprints you have a kitchen you can take the mitigated risk that is lower cost all things considered and by all things I mean. The the cost of finding a location putting an loa down um securing a building out blow this goes On. Um, so that's great. But I do think that there is a misperception or misconception from a lot of folks that all it is is create a fun name throw a logo together put some packaging together. Wham Bam. Thank you Ma see you later. 07:59.29 Justin Bartek Um, yes, yes. 08:12.67 Justin Bartek Um, right. 08:13.72 vigorbranding And get it out there and I think that my thinking is that it's going to lead to some of these set it and forget it brands. It's going to lead to failure is that something that you see that you're seeing is that something that you guys are worried about. 08:29.36 Justin Bartek I would say not, We're not worried about that and it goes back to the product. We've tried all these brands right? where we always are like let's try this one. Let's see this barstool whatever like but what is it and we get the packaging. We see the food like ah great. 08:40.85 vigorbranding Um, yeah. 08:42.48 Justin Bartek And it's not. It's nothing that I really would ever want to order again and I don't want to trash. Anyone's brands but like it's just the the name of the game you know, but it's like it's like dude like. 08:48.99 vigorbranding Let's track him come on. 08:53.60 Justin Bartek Is Barrstol really spending time to do that research is Mr. Beast really out here testing food like that you know, no, he's not he doesn't have time to do that. We know that and plus when it's not your passion like when I when I see Mario Lopez Tacos do I ever want that? no. 09:00.46 vigorbranding Um. 09:08.96 Justin Bartek Is he known for tacos. No, he's known for being Latin right? like so on du like you just now it's getting stereotypical like it's just funny to me that um you know it's just they don't have the the culinary background right? and I think where doghouse shines is we are. 09:11.54 vigorbranding Um, right. 09:21.30 vigorbranding Right. 09:26.26 Justin Bartek Created by people that are very into food that was the goal from day 1 we use King Hawaiian roles we do we do all these things that are a little different and we really focus on quality like creekstone farms is our our meat provider. Let's say no antibiotics like it's not a joke here like we talk about it but we we need to talk more about it because I think. You know today's guests especially the younger ones they care about those things they care about the environment the planet where where things are sourced. You know they chipotle is you know for what they are if they've done that job of like hey we we're selling you something better. Is it really I don't know but they talk about it right? So we we kind of we're leaning into that as well like let's put it out there what we're doing because. 09:58.27 vigorbranding Right. 10:04.16 Justin Bartek You are paying for that quality and I think you know from what I've heard from our team only being here five or six months you know in the past it's like how do you get someone to pay $8 for a hot dog when Costco sells for a dollar 50 10:15.21 vigorbranding Right. 10:16.77 Justin Bartek So that's ah, a unique challenge for us. But it's like how do we do that with high-quality ingredients telling people about the ingredients making these exotic builds and things that look different. It's not just a hot dog and you know that when you once you see it, you know so it's that's our job to really get in front of people. 10:26.38 vigorbranding Sure, Yeah yeah I Love the approach there and so you're you're really zeroing in on the quality of product That's not a different story I mean everybody thinks Well I won't say everyone that's blanket right? So many people think that their food is quote unquote the best. 10:42.56 Justin Bartek Friend. 10:44.70 vigorbranding Um, but I think what you started to unpack is reasons to believe why it has a better flavor profile those Kings Y and buns the quality of the product. Um, and how you're putting it together and I think that culminates to give the market reasons to not just acknowledge but believe and you're right. 10:52.53 Justin Bartek A. 11:04.48 vigorbranding What does Mr Beast bring to that table. So 1 thing that he has that even y'all don't have is a loudspeaker. Um, you guys have to pay for that right? So you have to go out there to put paid media together. You have to get the you know influencers god forbid I say that word um god I hate that word so much. 11:12.10 Justin Bartek Um, prayers are. 11:18.54 Justin Bartek Let me. 11:23.28 vigorbranding But you have to get influencers to go out there and also add um gravitas to those claims because no one's going to believe it coming from the Brand's mouth. But once the word is out and you've brought someone through that early funnel using marketing speak to a point where they want to try with Mr. Beeer less with little substance. 11:36.34 Justin Bartek You. 11:42.88 vigorbranding With barstool um I'm actually not familiar with their brand I probably their brands I know barstool sports but not their virtual brands. But I would I'd have to imagine Dave Portnoy does have a pretty good stranglehold on pizza and I would say he may have a better stranglehold on pizza than. 11:55.39 Justin Bartek 5 12:02.72 vigorbranding Many other pizza people out there just because of that series I don't know if you've seen it. But yeah. 12:05.11 Justin Bartek Yeah, well, what's funny that brand they don't they didn't they weren't doing pizza. It was wings right? exactly. It's yeah, it's one of those things. Dude it's like um. 12:13.40 vigorbranding Okay, great. Yes, so like why not do pizza. It's like like ah. 12:21.00 Justin Bartek To take it away from virtual for a second just to to talk about this like dobrick dobrick has a pizza shop now here on sunset no one's going there for the quality of the pizza watch any review I I saw one last week with Portnoy testing it and he's like I know you're my boy but dude. And he was really honest like I don't think I'd eat this again, you know and it's like very interesting and what we're seeing with that is like yeah the fame carries it so far. But it's like with any brand. Yeah, you want to open big those are all going to open big because they do have that that megaphone and they can blast that message out hey great but is there are people buying it again. 12:39.10 vigorbranding Um, yeah. 12:55.31 vigorbranding Right. 12:56.59 Justin Bartek You know I mean that's all that I care about because yeah, you'll have this huge splash. Yeah, you might have millions of people interested. But if you don't deliver the first time like any brand people aren't going to go back so over time to to one of the questions you would ask like are are they going to die. Are they going to do this. They might not die some of them are definitely going to die because people aren't going to order them after having it once and then. 13:14.25 vigorbranding Um. 13:16.55 Justin Bartek You know restaurants are not going to serve them anymore. There's because say you know what that one doesn't Work. We're just not seeing any orders. Why are we doing it and I think that's what's going to Happen. It's going to take time. But I think you know even though it's cliche that quality piece matters and especially in delivery because you don't want to get something that sucks or you know you waited Now. It's not good or. All those things matter on delivery in ah in a major way. So yeah, they have the fame and they can say hey here's this virtual Brand I didn't have to do anything I just put my name on it here here's the burger if you order from a different Mr. Beast Did you know that there is no standard like the meat quality doesn't matter to them. They say here's the build but they don't care what meat you're Using. They don't care what condiments. It's just yeah, you use ketchup use mustard to use this meat So every time you have it. It could be a different experience depending on where you get it. That's not really what people look for and brands in my opinion. So another advantage for someone like us who. 14:11.43 vigorbranding Um, yeah. 14:11.70 Justin Bartek Does have that standard and you know what you're getting every time with us. So. 14:16.13 vigorbranding Yeah I think there's like this misconception from folks that are either novice novices to the industry or um, play on ah on a lower scale I think it's a nice way of saying it where those things don't matter and it's like. 14:28.48 Justin Bartek Yeah. 14:32.81 vigorbranding Make it as cheap as possible maximize the profitability get the money and go. But I think now more than ever The the delivery game has changed it I mean you're paying a lot of money you know for something that would otherwise be very like very inexpensive like if I got that same Mr Beast Burger Let's say. 14:42.75 Justin Bartek Yes. 14:51.83 vigorbranding You know at a park out of a truck and it and it wasn't it was different than but the one I'm used to like I probably wouldn't care too much. You know what? I mean I'm like hey it's got the things that's fine. But after I've paid for the fees and the delivery fees and I have to tip the guy. 15:04.59 Justin Bartek Yeah. 15:06.75 vigorbranding You know I'm paying more for all that than I am the actual product and that thing comes back tasting like garbage I mean that's horrible. Yeah. 15:11.67 Justin Bartek Highly disappointing right? like when that happens you're just like and it leads to in the delivery game. It's like I feel like a lot of people just probably have a few favorites. You know I mean they can trust it. They know what they're going to get even if they're like I'm not hungry for Chipotle today but you know if that bowl comes. Gonna be what you want pretty much and it's the same thing every time right? But for others, it's like if I have to do trial and especially with a food like a hamburger. Not the best you know situation for traveling obviously fry same thing like they're gonna get not as good advantage for us tots. 15:32.98 vigorbranding Um, yeah. 15:45.63 vigorbranding A in. 15:46.87 Justin Bartek Tots last longer. You know what? I mean like little things like that where it's like we don't we're not going to lean in to fries the way we set up our virtual menus like tots are going to be number 1 just trying to think in those ways where it's like what what does the guest want and need and then try to outthink them if that makes sense and say. What are we gonna deliver that they don't know they want or can we set it up in a way where it's like they're sort of fallen where where we say this is the best of our menu because we know it's going to take twenty or thirty minutes to get to you so maybe avoid this go with this right? You're still going to get great flavor all that but we' that's. Where we're at now too is really just engineering that menu or the the menus and trying to get them to that place and we're also playing with like you know menu positioning so like on on our virtual brands. What's the order on the dsps versus our own site does it matter. How does it work. what what are the sales differences. All these things we're trying to just get a lot of data right now and. And push that forward and then the other piece kitchen night I mentioned they are a partner but they're actually building an os for us that will live on top of toast where we'll have multibrand ordering and with that in the same basket meaning multibrand loyalty which is really exciting for us because if you're a doghouse. 16:39.73 vigorbranding Um. 16:45.38 vigorbranding In. 16:58.51 Justin Bartek User or fan and you've ordered and we have your history. We know what you're doing but you've never tried Badass Breakfastry here's an email you you got to try this here's your discount here's whatever that is. It's like tying all that together is really exciting because now people really know that the brands are connected in that way and they're like oh I like the doghouse calling y I'll probably like. You know, bad mother KClucker I'll probably like Badass breakfast brito that that looks Amazing. So we'll be able to tie that together so that kind of is going to change our whole marketing strategy Once that's ready to go this year. Um, and then then on my side. Obviously you know me, but ah I push for digital I have a partner with partnership with hyperlocology. 17:18.38 vigorbranding Um, right. 17:34.97 Justin Bartek We're already talking about dialing into that direct ordering once this K U environment's ready because every marketing piece is going to go direct direct orders you know, um, collect the data retarget. 17:43.54 vigorbranding Bright. 17:47.68 Justin Bartek Find lookalikes. The whole thing is going to be dialed in in a way that this brand's never had it before so we're really excited about that because in conjunction with this k u thing with Hyperlocologist help. It's like we're going to drive transactions direct for our own ordering you know and then we'll get away from fees that way we'll be able to subsidize the order. Um, fee or you know the delivery fee through our partners but it's still cheaper than giving them 2025. Whatever you know these guys have signed up for in the past. So that's really exciting and that's just going to open up a new world and I know you you talk about this probably a lot on these pods just in in your career but like the data piece. 18:22.40 vigorbranding E. 18:24.35 Justin Bartek Restaurants still struggle with it because we don't have a data data analyst on our team but we know we need that data. We need to take that data and then. Use it in ways that will help us grow our brand or grow repeat business or grow. You know, like whatever that thing is but we need to harness the data and start using it. So that's that's been a huge goal for this year as well. 18:40.70 vigorbranding Yeah, it's huge I mean everything is providing data these days but rare is the case that you find folks that really know how to use it. So my friend Tammy billings She started abe and aben's been pretty great to look at from outside looking in as far as harnessing some of that. 18:48.40 Justin Bartek Right? yeah. 18:57.49 vigorbranding Sales data and getting really nuanced with when people are buying when people are making buying decisions. Um you know and hopefully hopefully I'll get her on the podcast here soon. But um, you know that's why here at at Vigor Povon we have a data science team for that very reason like it's like we know you have data. But what are you doing? What story are you excavating from that data that can help you make decisions on things like buying behaviors on things like um, where where not just profitability. But how can you maximize that profitability. How can you maximize order counts and order averages. Um, but a lot of it just comes from the gut. 19:33.84 Justin Bartek Definitely yeah. 19:36.44 vigorbranding So that's that's really troubling now one side of this that really we haven't I haven't really dove into it with anyone and but it's really intriguing to me and since you're kind of on the front lines here is the innovations in packaging you know so you mentioned the the french fry game which I mean anybody that works with Frenchchris we know. It just the sweating makes them suck and it's really tough to keep a well-balanced crisp to to a tooth ah balance in there but what innovations crip crip the tooth. Yeah, it's really important. 19:57.39 Justin Bartek Yeah. 20:09.13 Justin Bartek Crisp the tooth. Love it crisp the tooth. Ha. 20:13.69 vigorbranding I'm but I'm borrowing tooth from the Pasta world. But yeah, it's um, what are you seeing as far as innovations and then what kind of Impact. Do you think that's having on the bottom line because as we know innovations when they first come out cost more. Because it takes a while for the very you know the demand to catch up with the supply and therefore drive prices down. 20:32.91 Justin Bartek It's Funny. We we're in the middle of packaging you know like we're figuring out how what package you do want to go with in the near term in the short term. It's like we have some packaging that looks nice, um, with hot dogs a little different so it's like a tray and then you slide it into a box and it keeps it well. But. Is it hot Enough. It's Cardboard. You know it's not.. It's not ideal right? Fryes same thing like we don't have great fry packaging solutions right? now here. But at other brands I worked for like hello guys they solved it if you've seen their fry package. It's pretty awesome. It's got holes in it holds? Well the lid shuts like. 20:50.93 vigorbranding Right. 21:08.74 Justin Bartek I Would love for us to go to something like that. Um, but literally I can't really help you with this because we're in the middle of like trying to figure this out. We've got our designers working on the look and feel but as the actual products like we're taking a look at everything and we're probably like a lot of brands like okay what for our brand. What makes most sense you know like our burgers are pretty big. They're square right? but they're. 21:25.30 vigorbranding Um, yeah. 21:28.63 Justin Bartek Hawaiian roles. So you got to think through that How does that work right? like there's a lot here where things you don't have to worry about at other brands we sell corn dogs like how do you get a corn dog hopped someone in the most in the best way so it doesn't break while it's on the way you know there's things like that. So we're really, we're really in the middle of it right now trying to figure it out just like everybody. 21:41.50 vigorbranding Right. 21:48.20 Justin Bartek Um, but to your point it is a huge I wouldn't say a concern but it's like we need to solve it just like everybody else because we do want to get that quality product to you hot and you know crisp to tooth. 21:57.76 vigorbranding Yeah, it's um, you know may I think obviously there's there's innovations that that happen with the packaging too. But I wonder what what can these dsps delivery service providers for those that don't know. Um, what can they do to help out. You know like I'm I'm surprised we don't have um modular solutions that have both hot and cold that can be put into vehicles. Um, you know because then that would make our jobs a little bit easier when we're thinking about innovating and that hey we know the hot side is going to be capped at one forty one sixty, whatever that that temperature is. 22:33.74 Justin Bartek Pronounce. 22:35.84 vigorbranding Um, but if you're going to provide delivery I think the means of transportation is only 1 facet like you know you're talking about food and and part of that's food safety which is really tough. 22:41.83 Justin Bartek Um, yeah yeah I remember you know a few years ago when it was really happening. Everyone was looking for stickers like how do I seal my bag because before that we didn't even do that right? you might tie it. You might do whatever it's like. 22:54.40 vigorbranding Um, right. 22:57.19 Justin Bartek I Got to seal it to make sure that you know a driver doesn't accidentally grabs some fries out of it or whatever you know, like course the horror stories but it's true. You know you need all that. So um I feel like that part of it. You know was Covid really pushed a lot of you know hey we got to figure out this to go packaging and like. 23:00.80 vigorbranding Um, yeah, um. 23:14.50 Justin Bartek Like you said when I was at Virginia when I started at Virginia 8 stores even had delivery even had online ordering 8 right? We had to build it in two months we had to set it up. We needed to talk to dsps like a lot of our stores didn't even do third party Virginia because they didn't need to. 23:19.49 vigorbranding E. 23:30.95 vigorbranding Um, yeah, well and soups a whole nother level man like get yeah. 23:32.12 Justin Bartek You know and saying like they made enough money. Yeah, and they were just like we're good. We're good. So I know that really from the frontlines of Virginia we had to figure that out within a month or 2 and really get to go and negotiate contracts set it all up with all our franchisees make sure they're on board make sure they know how to execute you know change the packaging. 23:49.11 vigorbranding Um, right. 23:50.64 Justin Bartek We actually set up some some stickers at Virginia that named the which bowl of ramen you you get which sounds so like yeah of course you should do that? No they were using a grease pencil for years because they didn't have a lot of words so like sure whatret then stickers became mandatory we needed it. You know it helped the guest immensely because you're getting 4 bowls if you're ordering 2 rains soup. 23:59.40 vigorbranding Um, yeah. 24:10.90 Justin Bartek Toppings soup toppings knowing which is which is huge and especially for someone who might not order ramen a lot so we saw we saw our guest satisfaction go way up once we started doing that we saw it on reviews. We saw it everywhere like oh we love these stickers because now we you know we really know that that's ours. You know if we have a multiple order So little things like that go a huge go a long way. Um. 24:13.26 vigorbranding Um, right. 24:29.74 Justin Bartek But you know I just think the packaging experience is very top of mind here and we're trying to solve that this year because we know you know it's it's got to be done especially across our brands like we when they started the brands it was right when covid started so like the bag they're like let's do it cheap. 24:38.51 vigorbranding Um, right. 24:49.14 Justin Bartek Here's a stamp of the logo. So literally we've got people at the restaurant stamping bags Badass Breakfast burritos and that was our that was our packaging Now we're like let's pick it up a level. Um, you know we could license this brand potentially to another brand. We got to make sure we have everything died in so we're working through it. But it's all important man. 24:54.32 vigorbranding Um, right. 25:05.35 vigorbranding yeah yeah I mean and I think that's that's the thing there's like no 1 thing that should just be painted over but I do like the idea I mean especially when you're starting something up, um a lot of places want to do it perfect but perfect is undefined because you you don't really know what people are going to be buying in what kind of volume and so. 25:08.57 Justin Bartek F. 25:23.14 vigorbranding You know we're big proponents of like get the things set that you know for sure are borderline immovable but also be ready for that evolution. Be ready to learn and iterate and iterate um quickly and if you were in Silicon Valley God I Hate to say this now considering the the things with the banks but like fail fast. 25:25.92 Justin Bartek Right? yeah. 25:42.10 vigorbranding You know and the whole idea of failing fast is learn. What's not working adjust iterate. Try something new until you get the right thing rather than trying to turn every knob perfectly and wait for the perfect moment because there is no such thing. Um. 25:42.16 Justin Bartek Yep. 25:47.42 Justin Bartek And. 25:55.16 vigorbranding You know how how much of that. Are you guys employing how much of that mentality are you putting to use when you when you think about these innovations. 25:58.61 Justin Bartek We definitely are not not on like packaging per se even though we were talking about that but like happy hour. Let's say we've got different franchisees in different parts of the country and some might say hey we need x on our happy hour menu because this local audience will react and for the longest time. And this is at every brand but they're like no, we have our set thing here. We're sticking with this even though it might help you there. We don't have the bandwidth to create this for you one-off style you know like every brand goes goes through that we've been going through that. But how we're how we're solving for is we're allowing certain franchisees to. Try things. We're setting up committees where it's like there's a packaging committee. Let's say um, there's a happy hour committee. There's all these committees with like maybe 4 to 5 franchise partners but like it's the ones that that's their specialty. Let's say so the guy that sells a ton of delivery. We want him on the packaging because he's going to know right? He's selling the most. So. 26:35.29 vigorbranding Are. 26:53.35 Justin Bartek Um, That's how we've tried to kind of set this up and we'll let them try things then we'll come back together say how's that working for you. How has that impacted sales. How has that impacted your cost etc and then we'll sort of keep the ball rolling and we'll say all right? We're going to implement this now everywhere take this these learnings. This was the best thing because we are of the we're the kind of people that you know. The best idea wins. Not my idea you know it's just we want The best idea we don't care where it comes from. So um, we're really into that now this year. We've honed in on these committees and I think even though I wasn't here what I've learned from this brand is communication communication communication because when Covid happened. 27:13.83 vigorbranding Um, sure. 27:30.17 Justin Bartek Franchisees were freaking out. They didn't have any of the virtual brands. They only had doghouse. They made the decision the first week when everything shut down. Hey let's turn them on. Let's go and it was a complete leap of faith because we didn't know how we were going to do it. We didn't know how to do 6 brands at the same time you know, but like worked our way through had the partners. 27:32.67 vigorbranding Means home. 27:47.92 Justin Bartek Um, the partners had our backs meaning our our founders but then franchisees every week at a weekly call How's it going here's what we're learning kind of triaged our our team. So. It's like you're an expert in delivery. You're an expert in design. You're an expert in this and we would bring things to the table every week as it was happening so like hey. Ah, Panera Bread's doing this and it's working for them and just letting our french disease know like this is what's out here. Everyone kind of became an expert in a certain you know piece of this and then we just would communicate and overcommunicate and I think that really helped this brand survive it. Their sales actually came out higher because when they launched the virtual brands they got about a 30% pop. 28:24.67 vigorbranding Um, nice. 28:25.87 Justin Bartek So It really was a smart thing to do at the time. But even though I wasn't here. It's likeve been talking to our team. It's like that's how we attacked it. You know, just everyone kind of became an expert. Everyone would talk overcommunic communicate and really I found in my career communicating communication in general most important to franchisees to operations for me being a marketer. Um, early ah in my early early days like baha fresh I Just remember going there and like ops didn't talk to marketing or at least they were always at odds they might have talked and it was friendly in the hallway. But when it came to decisions. Everybody's at odds? No One's on the same page. That's how it was there from that job I really took that to heart and said look the only way as a marker I'm going to get things done. 28:52.34 vigorbranding Um, right. 29:04.87 Justin Bartek Are lockstep with ops either good cop, bad cop or what do they need from me to help them and then they'll help me you know So I've always tried to attack it that way in my career but it's coming from a place where it was not like that and it was very obvious and it could've been way better. So I always just tried to take that. 29:13.24 vigorbranding That's right. 29:21.99 Justin Bartek You know as I moved on in my career for sure I have. 29:23.83 vigorbranding There's a good lesson learned. Um I would say 1 idea to bring to the table for you guys this one's free by the way is remove the word committee and I think you should take inspiration from imperialist Britain um and change it to ministry. 29:34.91 Justin Bartek Um, okay I love it I love that I'm gonna put that on my Linkedin. Ah. 29:36.72 vigorbranding So the ministry of packaging innovation like now something you want to put on your resume. But yeah, yeah I am ah the leader of the ministry of amazing marketing solutions I Love it. 29:51.48 Justin Bartek Ah, there you go and you know. 29:53.95 vigorbranding Well so you're kind of at the forefront. It's going on in in the virtual space and um, you know it amazes me every month as I see more and more brands kind of come and I think some are dying off something slower than others some quicker than I expected. Um what? What do you think is next up for. This massive digital shift and and virtual brands and do you think we're going to start to see a convergence of virtual concept that do so well that they actually find a place in brick and mortar. Um, what? What's the big forecast from Senor Bartek 30:23.11 Justin Bartek I think that's going to happen I I think what will happen and it depends if you know maybe at a Ceo level if they'll let it happen but I do I think that licensing brands that are popular is going to become a thing I think we're obviously on the forefront of that now talking to some people. Can't talk about who but like there's some things where it could be thousand locations and it could be tomorrow. So if that happens that as breakfast burrito we become a burrito brand right overnight which is kind of scary but our founding partners are talking about already like you know what? that means like it's a thousand locations where we would do everything we would do all the marketing we would do the packaging all this. We're already preparing for that. But I I really do see that I think a lot of the flyby night celebrity led brands will go away I mean it's just it's gonna happen because of quality control I feel more than anything also in that world. You know when you're whenever you're dealing with celebrity. It could be here today. Gone tomorrow. 31:12.94 vigorbranding Right. 31:21.80 Justin Bartek I mean like yeah Mariah Carey has staying power and she's probably not going anywhere but like do people are people going to care about Mario Lopez if he's not on that show anymore or Mr Beast he could have some who was the other guy online and said something and then he was just erased like the next day right like 31:27.61 vigorbranding Every. 31:35.98 vigorbranding Um, yeah. 31:37.65 Justin Bartek That kind of thing happens and then it's like maybe Mr Beast goes away. He slips up and says one wrong thing all of a sudden. He's banned or whatever right? So I just feel like those type of brands aren't here for the long haul I feel like if it's chef driven or brand driven and you you know that food that's where it's going to be I think you know, um. 31:42.79 vigorbranding Um, yeah. 31:55.92 Justin Bartek Who who does a great job like fukoo you know anything like this you know you're getting from Chang you know mean like Chang is going to kill it. So um I just think it's more chef-d driven more brand driven. It's more about story. You know how it is with the youth you have a kid now. 31:58.90 vigorbranding Um, he's crushing right now. Yeah. 32:10.36 Justin Bartek They they care about the planet they care about. Maybe not yours not old enough to care about anything the the bathroom and food but you know I mean just the the way the world is going I feel I feel like the real stories are more important than ever you know I mean telling your real background telling your real history and then having people buy into that by saying you know what. 32:10.47 vigorbranding Um, yeah, not yet. Yeah is great. 32:29.45 Justin Bartek I Like that too or I'm that way too and I combine into that and I see where these guys are coming from or I see where these ladies they started in their kitchen. They did this whole thing Now they have this brand like I love stories like that even out here I mean I don't know if you've been out here in a little bit but we've got this brand home state which you may have heard of it's it's ah it's. 32:46.81 vigorbranding I Don't know if it did okay. 32:48.33 Justin Bartek Ah, a woman from Texas but she does breakfast tacos and she makes Caso and she's got she's a triplet so she has 2 sisters but it's literally like just they started here. They brought these recipes here and now I think they have 6 or 7 locations but it's a brand I love because it's like the vibe. The music they're making tortillas by hand. 33:06.11 vigorbranding Um, yeah. 33:07.90 Justin Bartek Great food. You know it's just like they're doing a great job and it's the kind of brand that could blow up and that's what you want, You know you mean they have a story they're in the community. They they do donations they work with music artists to do their you know foundational kind of things. It's just like that's a kind of brand I Want to be a part of I don't feel bad spending my money there because I know that she's. 33:17.30 vigorbranding Right. 33:24.40 vigorbranding That's right. 33:25.50 Justin Bartek You know doing it in the community and really doing a great job. So I think brands like that are are what people will focus on in the future and especially the youth think as we grow you know we're old. We don't yeah we like what we like but like these these young kids are are the future Obviously but they're the ones that are like what do they stand for that matters which back when I was. 33:35.57 vigorbranding Um, yeah to bummer date. Yeah. 33:44.37 Justin Bartek I think I went to Burger King and I'm saying I didn't care what their politics were or whatever I went to these restaurants I didn't care now. It's just it's a cultural change and I think those that are equipped to deal with that or at least have a story or bring something to the table are going to be in a better position than those that don't. 33:44.54 vigorbranding Um, yeah. 33:59.33 vigorbranding Yeah I mean I think patrons you're you're tapping into it outside of the philanthropy and the the political statements and stuff like that I think those are all um surface level outputs from a deeper need and I think that need is to feel like a sense of honesty. And the sense of real like you mentioned with home state like I just want to feel like it's real I want to feel like I'm not lining the pockets of some fat cat wall street blah blah blah and you can go down that whole you know rabbit hole. Um, but only because you brought her up I'm going to bring bring us back to that for one second if Mariah Carey opens up a Christmas cookies brand. 34:22.70 Justin Bartek Um, and. 34:36.88 vigorbranding Um, buying them I'm buying them like a lot like I just think our principal that's right, yeah and she doesn't want a lot for Christmas she only wants you and these delicious cookies. Ah. 34:38.50 Justin Bartek Yeah, you know why? ah you she knows Christmas probably better than anybody no to buy a cook. Yes. 34:54.40 vigorbranding Ah, ah, um, that idea is copywritten if you do decide anyone listening to connect with Mariah Miscarry and I expect to be called I want I want royalties and I think it's a brilliant idea in the making. Um. 34:55.62 Justin Bartek See whatever. 35:09.67 vigorbranding So last time we had you on. We asked you what your 1 final meal would be I think it'd be kind of unfair to do that again. Um, so why don't we water that down a little bit and ask you what is your favorite meal right now or your favorite place to eat. What are you loving the most. 35:14.87 Justin Bartek Um, yeah. 35:27.60 vigorbranding Not You can't say anything from doghouse because that's obvious. 35:30.30 Justin Bartek Yeah now. Um you may have been to this spot. But you know Javier's that brand I think there's about 6 of them vegas here couple places. Um dude I love their food I love that whole menu I could I could go there and try something different. 35:36.12 vigorbranding Yeah, yeah, yeah. 35:45.88 Justin Bartek Thirty days in a row and be satisfied every time I mean it's just an amazing experience. So ah, for fine dining mexican food on on the coast like going down there. It's one of my favorite things to do and also the people watching because you could imagine Newport Coast like who's going there and it's just hilarious. 35:50.50 vigorbranding Um, yeah. 36:03.40 Justin Bartek For someone like me I'm just like I love it. So I just like the people watching or load the food. They've got an amazing bar like just attention to detail with javier himself I have a friend that actually it's a random as story but maybe ten years ago the first time I went. 36:03.43 vigorbranding That's right. 36:18.76 Justin Bartek He played on javier's basketball team they were in this like wreck league. So he knew them so we would go there. My wife and I and a couple friends and Javier's there comes to the table and like. 36:23.70 vigorbranding Um, okay. 36:30.30 Justin Bartek I had never been there so I'm just like this is amazing like there's just like is like this every time it's like no because my friend was with us that knows him but he's bringing out kcd is doing the whole thing and it's just like such a nice time but that was the first time I went and then ever since I just like love the brand the attention detail the the quality you know like that's the kind of brands I want to work for or be a part of so. 36:30.52 vigorbranding Yeah. 36:49.78 Justin Bartek I would say Ha Yearss and there's nothing on that menu I wouldn't need but you know the the molay enchiladas are Killer. So yeah. 36:55.94 vigorbranding Cool that sounds Killer man. Um, yeah, next time I around one. Maybe it's Vegas for a trade show or maybe I get out there to to the L a area again. We'll have to we'll have to go look man. Thanks for being so generous with your time and your insights and your ideas It's great having you on again. Um. 37:05.70 Justin Bartek Um, yeah. 37:10.33 Justin Bartek Um, course. 37:14.23 vigorbranding And hope hopes to connect with you real soon. 37:16.71 Justin Bartek Anytime Buddy Thank you. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum. --- Send in a voice message: https://podcasters.spotify.com/pod/show/cache-me-outside/message

Argonaut Manufacturing Services Inc. CEO, Wayne Woodard, joins the Patient Empowerment Program to detail how Argonaut bottles vials of hope for n-Lorem patients. Argonaut is n-Lorem's provider of Sterile Fill-Finish for an optimal ASO. This means that the lyophilized ASO powder, which was manufactured with good manufacturing practices (GMP), gets formulated and aliquoted into sterile vials. The final product is tested for various attributes to ensure maximal quality. Once assessed and approved, the finished product is then ready to be administered to a nano-rare patient by a qualified research physician at an established institution.

Gay Grossman is the mother of an n-Lorem patient and co-founder of ADCY5.org. She has been active in the rare disease space for 25+ years and continues to fight and advocate for patients every single day by connecting ADCY5 families, speaking at events, and informing the entire rare community. On Wednesday, Gay joins the Patient Empowerment Program podcast to discuss her daughter, Lilly, lessons that she has learned as a rare disease mom and advocate, the difficulty of gathering and sharing medical records before the creation of Ciitizen, and why newborn genomic sequencing should be introduced in the United States today.On This Episode We Discuss:0:00 What is Ciitizen?3:14 The difficulty of sharing medical records before Ciitizen5:55 Gay's daughter, Lilly, is an n-Lorem patient10:00 Finding an initial pediatrician to help Gay and her family diagnose and understand Lilly's gene mutation11:45 Lilly's nightly seizures and wondering what it would take to receive a diagnosis15:05 How caffeine helps Lilly and others with ADCY5 mutations18:35 What Lilly is doing nowadays19:48 How Lilly's genes were sequenced21:00 Advocating to introduce newborn sequencing into newborn screenings23:30 What was known upon diagnosis and other's with ADCY5 mutations28:13 Lessons that Gay learned from her 25+ years of rare disease care and advocacy33:19 The progress n-Lorem has made since inception

On the island town of Slumberland, a tower built from yellow bricks has stood for over a century. This structure is known as the "Lorem Lighthouse." A student named Elaina McElian just finished her research report about the lighthouse, and she's excited for you to hear it. For more info click here Elaina McElian performed by Alex Nursall, a director, writer, illustrator, and chronically sleepy person based out of Toronto. She is the co-creator/writer, director, and voice of Judith on the award-winning horror podcast Parkdale Haunt (www.parkdalehaunt.com), and is also the voice of Mairi on the D&D Actual Play podcast Dice Shame (www.diceshamepodcast.com). She is a commercial voice and casting director in her day-to-day life, and in her off time enjoys watching F1, hiking, and trying every interesting baked good Toronto has to offer. Music by Blue Dot Sessions The sound design in this episode owes thanks to Freesound Project contributors: juskiddink, ianoboe, chocchi, kyster, avakas, webbfilmsuk, zoltoks, marateresa, hazure, cylon8472, sirkoto51, vartian, inspectorj, opticaillusions, khenshom and joedeshon. Thank YOU you for listening to Slumberland!

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We had the pleasure of interviewing Mereki over Zoom video!Australian/English savant of purposeful pop Mereki releases her debut solo album Death of a Cloud. Created over seven years and three continents, in collaboration with a roster of the artists Mereki trusted most to bring this deeply personal and intuitively conceived material to life, the album is a look into the joy and difficulty of self-realization and finding the universe within, expressing this journey through music – Stream.The album release comes along with the news of Mereki signing with BMG. Proving her success as an independent artist, her progress will be furthered through the creative efforts of BMG along with her own label BunBun Records.Leading up to her album release, Mereki put out the singles “Presence” and “Twin Flame.” The creation of “Presence” stemmed from Mereki getting inspired by the guitars reverberating through the walls while in a writing room above the studio where Dhani Harrison and Graham Coxon of Blur were recording. After she began singing a melody that became the first verse, she shared it with Harrison, and then the two were motivated to work together to complete Mereki's composition. “Twin Flame” sentimentally arrived the same week as Valentine's Day as a hymn to kindred spirits.Her singles were met with praise from the likes of Notion, Beats Per Minute, Soundazed and Mundane Mag, as well as editorial support from Spotify's infamous Lorem playlist, making the artist's return her strongest streaming to date.At the end of 2022, Mereki and her Be Kind charity partnered with the Happy Baby Community for a Presents for Presence holiday fundraiser. The campaign helped raise money, awareness, and much needed supplies for asylum-seeking new mothers and their babies. Happy Baby Community provides a holistic approach to healing which includes long term support for both mothers and children.ABOUT MEREKI:Indie Australian/English artist Mereki creates pop with a purpose – vibrant musical worlds that share messages of transcendence and healing without sacrificing the fun. Now based in the UK, she first moved from her native Australia to the USA where she quickly found a home in the spiritually minded creative community of the east side of Los Angeles, collaborating with an impressive collection of producers, writers, and musicians as she refined her song writing and voice, laying the foundations for what was to come.Mereki began writing and releasing music with esteemed writers & producers Dan Nigro (Olivia Rodrigo, Conan Gray, Caroline Polachek) and Justin Raisen (Charli XCX, Sky Ferreira). GRAMMY-nominated superstar producer Ariel Rechtshaid (HAIM, Vampire Weekend, Madonna, Adele) spotted her talent, prompting their collaboration, “Golden Boy”, recorded by fellow Australian icon Kylie Minogue. She scored writing credits with Phantogram and Atrak, and guest artist and co-writer credit on tracks with Dhani Harrison, Goldroom, Basenji, Flight Facilities and Holychild. While fronting Goldroom, she performed everywhere from middle America to NYC to Bogotá, Colombia, before going on to perform with electronic act Flight Facilities as their featured vocalist on the duo's sold out North American tour.Kindness and magic are at the backbone of everything Mereki aims to be and be around in her music and in her life. She finds expression for her message in many creative outlets. In addition to music, she is also working on a record label, a children's book, a book of poetry and a collection of portrait photography. In 2016, Mereki created Mereki's Clubhouse, a pop-up event platform with a focus on kindness and creating spaces to give a voice to up-and-coming female artists. The Clubhouse motto “Be Kind” grew into a non-profit organization of the same name.Through all her work with and for others, Mereki found time to create her own music. Her debut solo single, “Blue Lake”, was released to critical acclaim from the likes of Spin, Nylon and Flood Magazine. After enduring some personal tragedy and heartbreak, she found catharsis in a brief foray into high-energy punk rock, releasing a few singles that landed her music in a Victoria's Secret commercial. In 2017, Mereki returned to the essence of who she truly is with the release of the Beach EP. The songs on Beach have Mereki's signature style, a distinctly pop-feel with positive messaging, while tracks like “Spiritual”, “French Kissing” and “Got It All” also hold an ethereal, dreamy quality.Mereki's return to music marks what has already been an extraordinary year for her, including her UK live debut at the legendary Glastonbury Festival 2022, alongside appearances at a host of UK festivals and headlining shows in London.We want to hear from you! Please email Hello@BringinitBackwards.com. www.BringinitBackwards.com#podcast #interview #bringinbackpod #Mereki #DeathOfACloud #NewMusic #ZoomListen & Subscribe to BiBhttps://www.bringinitbackwards.com/follow/ Follow our podcast on Instagram and Twitter! https://www.facebook.com/groups/bringinbackpodThis show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/4972373/advertisement

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Amber Freed and Shanna Tolbert join n-Lorem founder and CEO, Stan Crooke, for the first ever Patient Empowerment Program Q&A episode. Amber and Shanna are two nano-rare patient mothers and rare disease advocates who have experience with the n-Lorem pathway to treatment as caregivers. Through their experiences, and by canvasing others in the nano-rare community, they've compiled questions aimed to help current and potential n-Lorem patients and their families become more knowledgeable about the process, receive advice, understand side effects, and more! Stan sits down with these patient families to have a conversation and together address questions from the nano-rare community. Question Bank:- How do you apply to be an n-Lorem patient and who do you need on your team to help? 05:26 - How does the Foundation assess cases? 05:26- Once a patient is accepted, what is the best way to track the progress of the ASO program? 12:45- Any advice for when seeking information from a research physician who isn't communicative? 14:05- How often should a patient expect to hear communication from a research physician? 15:50- What is hydrocephalus, and should patients be concerned about the side effect? 19:30- If side effects occur in treated patients, will subsequent patients be notified in real time? 30:55- What is the difference between an ASO and gene therapy? 33:55- How is n-Lorem defining an “optimal ASO”? 37:20- Can n-Lorem help patients who are severely advanced in their disease? 44:10- How can treating one person can lead to breakthroughs for many more? 39:40- What is Stan's favorite success story from his career? 46:20

When patients face the diagnosis of a rare disease, they face a costly, uphill battle to develop a treatment for their condition… that is, if they ever do.   Dr. Stanley Crooke is aiming to change that. As the CEO of n-Lorem Foundation, his mission is to provide personalized treatments to ultra-rare disease patients for free as long as they live, no questions asked. Thanks to his humility, coupled with the generosity of other individuals and companies, ultra-rare disease patients have a renewed hope to get the treatments others may not be able to provide.   Join Dr. Crooke as he reflects on his humble beginnings at Ionis, the approach n-Lorem takes to developing drugs for ultra-rare diseases, and what the future holds for research in this area.Show Notes  n-lorem Foundation  Charles River - Rare Disease  Vital Science S4, E01 Project ALS: Fueled by Love  2021 Rare Disease Trailblazers  BioSpace: n-Lorem Foundation Preps First Doses to Treat Ultra-Rate Disease Patients for Free  Ionis Pharmaceuticals  Nature Medicine: Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis  

The creation of a drug consists of a copious and complicated series of projects that are all intertwined. Andy Mehrotra, CEO of Unipr, joins the Patient Empowerment Program to discuss how Unipr's AI based cloud program, project, and portfolio management platforms allow organizations like n-Lorem to quickly analyze data to inform program management. Today, n-Lorem effectively manages more than 90 accepted patient programs thanks to help from Unipr. Discovering locations where productivity can be increased while maintaining quality in every step is critical to treating as many nano-rare patients as possible. On This Episode We Discuss:Andy's upbringing among physicians and pharmaceutical entrepreneurs Traveling the world to launch Humera Baring the frigid Boston winters at MIT Inspiration to found Unipr How biotech and pharmaceutical organizations can use Unipr to increase efficiency The partnership between Unipr and n-Lorem Unipr's focus areas: Increasing the probability of success, decreasing the operational costs, and decreasing the cycle time for drug development Why Andy would donate himself to help n-Lorem

Manish Raisinghani joins the Patient Empowerment Program to discuss how Target ALS fosters collaboration between academia and industry to research and accelerate the fight against ALS. Target ALS has funded over 50 collaborative projects. Greater than 50% of which have had an industry partner and over 60% have resulted in an ongoing drug discovery program. From their Innovative Ecosystem, 6 clinical trials have emerged. Target ALS' commitment to fight all forms of ALS, no matter how rare, is evident in their founding support of Silence ALS, an initiative that aligns Columbia University and n-Lorem to offer an integrated solution to identify, support and potentially treat nano-rare ALS patients. Target ALS hopes that one day, no patient, no matter how rare their form of ALS, is left behind. On This Episode We Discuss: Target ALS' innovative model Accelerating ALS research through collaboration How a single nano-rare study can inform the ALS research landscapeThe importance of understanding the fundamental biology behind ALS Committing to fight all forms of ALSTarget AlS' support for n-Lorem and Columbia University's Silence ALS Initiative

I'm a day away from just filling all these with that "Lorem ipsum dolor sit amet..." bullshit. Cause I never have anything to say after the fact. Enjoy! Our website: www.wearenotjoerogan.com For advertising inquiries, please visit: https://www.advertisecast.com/TheJoeRoganExperienceExperience As always, you can listen to every episode of The Joe Rogan Experience here https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk Support us here: https://www.patreon.com/jreepodcast Follow Joe on Instagram here: https://www.instagram.com/joerogan Follow Jamie on Instagram here: https://www.instagram.com/jamievernon Follow us on Instagram here: https://www.instagram.com/jreepodcast/ Follow Kamar on Instagram here: https://www.instagram.com/kamar_babar/ Follow Floyd on Instagram here: https://www.instagram.com/floydeeeee Follow the Subreddit here: https://www.reddit.com/r/jreepodcast/ Subscribe to our YouTube channel here: https://www.youtube.com/jreepodcast Beats by: Ghettosocks here:  https://open.spotify.com/artist/1AeYteGuRWeFyptpSz0y5b Movie Game Jingle by: https://www.instagram.com/tylerdevall/

ONCE UPON A GENE - EPISODE 175 Every Patient Matters - Discovering, Developing, and Providing Experimental ASO Treatments to Nano-Rare Patients for Free with n-Lorem Founder and CEO Stan Crooke Stan Crooke is the Founder and CEO of the n-Lorem Foundation. He's also the Founder and former CEO of Ionis Pharmaceuticals, the leader in RNA-targeted therapeutics. Under his leadership at Ionis, he pioneered development of the revolutionary antisense technology platform and created one of the largest, most advanced pipelines in the biotechnology industry. His foundation is now using this technology to discover, develop and provide personalized, experimental antisense oligonucleotide medicines to nano-rare patients for free, for life.  EPISODE HIGHLIGHTS What do you do at n-Lorem? With antisense oligonucleotides (ASOs), we design chemically modified pieces of genetic information and those pieces of genetic information allow us to target a specific RNA, which is the molecule that gets transcribed from your DNA to make the protein that makes cells work. Because we now understand that code very well, and because we have a lot of experience, we can be very rational, efficient and inexpensive compared to traditional drug development. In a nano-rare patient, a patient with a unique mutation in a single gene, we begin with this incredible advantage. We can create a genetic medicine for many of these genes and mutations and do that very rapidly and inexpensively and provide medicines for free to patients. What criteria does a family need to meet to become a n-Lorem candidate? The patient has to have a disease with a mutation that is present in no more than 30 patients in the world. By definition, our patients are truly unique and extremely rare. Patients also have to be genotypically and phenotypically characterized fully. A patient has to have a qualified research physician who can do all the work to understand what's wrong with the patient and then treat the patient with an experimental medicine after we make it.  How are some of your patients doing on the drug created for them?  The first patient that was treated with a personalized ASO that we were involved in was an 18 year old German named Anna who has a rare form of ALS. It manifests itself typically in early teens, and untreated is extremely rapidly fatal. Anna was desperately ill when the ASO treatment was started and we weren't sure if we'd even get the ASO to her before in enough time. She recovered and did remarkably well. She's now walking up multiple flights of stairs on her own with no ventilator. She has a speaking tube so her mom can hear her talk for the first time in almost three years. She's also planning to go to school. Anna even wrote a personal note to me, and for a patient with ALS to have the fine motor coordination to do that is really quite astonishing.  Where do you think we're going be in 5 to 10 years with personalized medicine? We look forward to being able to treat thousands of patients, which means we'll also be learning incredible amounts from each of these patients. We are committed to sharing what we learn and we'll have our first annual meeting of investigators, patients, and parents this year. As we learn more, then I think there will be more interest in this space, and as we create a model of quality, others can follow. I hope that as n-Lorem succeeds, we serve as a model for others to follow, and we drive policy changes that will enable more people, more technologies and more organizations to come to the aid of patients who are unserved. LINKS & RESOURCES MENTIONED https://www.mi-reporter.com/opinion/show-your-stripes-to-honor-rare-disease-day-on-feb-28/ https://www.nlorem.org/ https://www.ionispharma.com/ https://twodisableddudes.com/ https://www.ultragenyx.com/rare-entrepreneur-bootcamp/ https://open.spotify.com/episode/14RO0pNneHdpYxSqEzk1l7

ONCE UPON A GENE - EPISODE 172 From Cancer Biologist to Rare Disease Mom - Digging Into the Data to Better Understand SCN8A with Madeleine Oudin PhD - Professor of Biomedical Engineering at Tufts Madeleine Oudin is a scientist and Tiampo Family Assistant Professor at Tufts University. Her daughter Margo has two de novo mutations in the SCN8A gene, which causes epilepsy. She's navigating life as a rare, working mom and sharing her knowledge in an understandable and accessible way for other rare parents.  EPISODE HIGHLIGHTS Can you tell us about the epilepsy conference you just attended? The SCN8 community organizes the conference for clinicians, researchers and families every year at the American Epilepsy Society meeting. There were over 35 families in attendance who have children with SCN8A and it was amazing to meet everyone in real life. What advice do you have for parents who aren't sure about attending a conference? Meeting other people has made a big difference for me and I encourage others to find their people. Going to gatherings can lead to finding resources and there's value in connecting to others and learning more about a disease. Community is everything. As a scientist and now a rare parent, how do you look through the microscope differently? The impact of genetic testing surprised me in how vital it is when it comes to rare genetic diseases. When Margo had her first seizure and had genetic testing, the results helped to connect us to community. Genetic testing is vital for families to connect them to resources. What work have you done in the SCN8A community to help other families understand the disease and advance the treatment progress? Science communication is something I'm passionate about. Since becoming a rare mom, I started an Instagram account where I explain the science of the diagnosis and break it down so the information is accessible to everyone. I recently did a webinar breaking down the different treatment strategies for SCN8A.  Can you talk about Margo's acceptance to n-Lorem? We applied with our neurologist and were accepted into the foundation to develop custom Antisense oligonucleotide (ASO) treatments. In parallel, we're doing treatments in my lab on a mouse and mouse cells, testing out different ASOs to see if we can gain any additional insights. LINKS & RESOURCES MENTIONED ONCE UPON A GENE - Episode 139 - Remember Who You Are https://effieparks.com/podcast/139-remember-who-you-are Margot_thebrave on Instagram https://www.instagram.com/margot_thebrave/ SCN8A Alliance   https://scn8aalliance.org/ American Epilepsy Society https://www.ilae.org/ The n-lorem Foundation https://www.nlorem.org/ SCN8A Unraveled https://www.youtube.com/playlist?list=PL-RngxzecxdLsaJFQyerqqfGLarDe9MUt TUNE INTO THE ONCE UPON A GENE PODCAST Spotify https://open.spotify.com/show/5Htr9lt5vXGG3ac6enxLQ7 Apple Podcasts https://podcasts.apple.com/us/podcast/once-upon-a-gene/id1485249347 Stitcher https://www.stitcher.com/podcast/once-upon-a-gene Overcast https://overcast.fm/itunes1485249347/once-upon-a-gene CONNECT WITH EFFIE PARKS Website https://effieparks.com/ Twitter https://twitter.com/OnceUponAGene Instagram https://www.instagram.com/onceuponagene.podcast/?hl=en Built Ford Tough Facebook Group https://www.facebook.com/groups/1877643259173346/ Interested in advertising on Once Upon a Gene? Email advertising@bloodstreammedia.com for more information!

Where did lorem ipsum come from? The answer turns out to be just as murky as the nonsense placeholder text itself. Plus, a new game that challenges you to guess when photos were taken. And the best family sitcom of the turn of the twenty-first century is getting a revival.Links:The hero(ine) who invented Lorem Ipsum may never be known. (Slate)Lorem ipsum translated: it remains Greek to me (The Guardian, 2014)Lorem ipsum : nouvel état de la question (L'Intelligence du Monde, 2012)What does the filler text “lorem ipsum” mean? (Straight Dope, 2001)The History of Lorem Ipsum (Priceonomics, 2015)DeLorean Ipsum Contested Will: Who Wrote Shakespeare? by James ShapiroChronophoto‘King Of The Hill' Revival Ordered By Hulu; Original Cast Returning (Deadline)Jackson Bird on TwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

As some of you may know, our host Kira Dineen also co-produces the “Patient Empowerment Program” by n-Lorem. The podcast launched earlier this year and focuses solely on the needs of people with nano-rare diseases. These are people who have a unique pathogenic variant (aka mutation) that affects 30 or less people in the world, sometimes just one person. The host of the show is Dr. Stan Crooke, who will be a familiar voice to you if you are a long time listener of DNA Today. He was on Episode 141 where I picked his brain about nano-rare diseases. He is a scientist, physician, entrepreneur and the father of antisense technology. Dr. Crooke is responsible for more than 40 drugs in development including the famous Spinraza to treat people with spinal muscular atrophy. So this week we are sharing an episode of the podcast where Dr. Crooke interviews Dr. Sessions Cole about the diagnosed odyssey for people with rare diseases. Dr. Sessions Cole shares his career being a neonatal pulmonologist and his involvement in the undiagnosed diseases network (UDN). Dr. Cole estimates that it can take up to 12 years to get a diagnosis for a patient with a rare genetic condition and that there could be as many as 30 million of these patients in the U.S. who are undiagnosed. The UDN is working to elevate the awareness of the diagnostic odyssey these patients undertake and diagnose up to one third of patients who are referred to the UDN. Dr. Cole is part of n-Lorem's access to treat committee (ATTC), the committee that evaluates and recommends patients to n-Lorem. In this episode, Dr. Cole discusses the robust processes involved in the evaluation of each application to n-Lorem and the hope and value that n-Lorem is providing to nano-rare patients today.To hear other episodes of the n-Lorem “Patient Empowerment Program'', subscribe on Spotify, Apple Podcast, their website, YouTube, or wherever you stream your podcasts. The host is Dr. Stan Crooke, videographer is Jon Magnuson of Mightyone Productions, producers are Jon Magnuson and Kira Dineen. Stay updated with n-Lorem on Twitter, Instagram, Facebook, Linked In, YouTube and their website, nlorem.org. Questions/inquiries can be sent to podcast@nlorem.org. Stay tuned for the next new episode of DNA Today on October 28th! New episodes are released every Fridays. In the meantime, you can binge over 200 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. Episodes since 2021 are also recorded with video which you can watch on our YouTube channel. DNA Today is hosted and produced by Kira Dineen. Our social media lead is Corinne Merlino. Our video lead is Amanda Andreoli. Our outreach Intern is Sanya Tinaikar. Our Social Media Intern is Kajal Patel. And our Graphic Designer Ashlyn Enokian.See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNAToday.com. Questions/inquiries can be sent to info@DNAtoday.com.

We had the pleasure of interviewing Danny Dwyer over Zoom video!Hailing from St. Louis, MO, Danny is an LA-based singer/songwriter & producer whose genreless music straddles indie rock, alternative, pop, and everything in between. He grew up learning jazz and playing in punk bands which eventually led him to college in Los Angeles where he studied music and started working on his solo artist project.Following a break-up in 2017, Danny turned to writing as he released his first song ‘What You Want' as part of a school assignment. Mixing contemporary R&B with his love of indie music, the song's early success inspired him to pursue his solo artist project. A genre chameleon, Danny seamlessly straddles different musical styles and sounds, bringing in diverse musical influences from his childhood and development. Recent collaborators include Benny Sings, Billy Lemos, Roy Blair, Ritt Momney, Magdalena Bay, RAC, Maria Isabel, Kllo, Maude Latour, Chloe Lilac, MILK, Marcos G, Jelani Aryeh, Brandon Banks and more.Danny's music has been featured in playlists such as Spotify's Lorem, Mellow Morning, Mellow Mood, Fresh Finds and Alternative R&B and Apple's INDIY, Day One and more. Danny has also received press from outlets such as Pigeons & Planes, OnesToWatch and Office amongst others. Mortal Kombat” is the fifth single off the anti-pop artist and producer's upcoming debut double EP, Losers, an emotional portrayal of liberated youth. The EP is a love letter and a goodbye note to his rural stomping grounds of the Midwest. “I used to feel the need to exploit as much as possible from any opportunity,” Danny says of the way LA twisted him. “Now I want to work on my bike and make sense of where I come from and where I am. All of these things I've compartmentalized for so long are now colliding.” The result is a collection of coming-of-age songs that have one foot in Friday Night Lights and another in Harmony Korine's Kids. WATCH "MORTAL KOMBAT" - https://youtu.be/b9S1AjXSBhI We want to hear from you! Please email Tera@BringinitBackwards.com. www.BringinitBackwards.com#podcast #interview #bringinbackpod #DannyDwyer #Losers #LosersEP #MortalKombat #NewMusic #zoom Listen & Subscribe to BiB https://www.bringinitbackwards.com/follow/ Follow our podcast on Instagram and Twitter! https://www.facebook.com/groups/bringinbackpod