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MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 18, 2017 All you need to know about CNS Lyme disease in 10 minutes or less. More to come in a few weeks when Dr. Colin Quinn shares his experience with what was "definitely not Lyme disease." Stay tuned. Produced by James E Siegler. Music by Josh Woodward, Chris Zabriskie, Peter Rudenko, Advent Chamber Orchestra. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCESHalperin JJ, Shapiro ED, Logigian E, et al. Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2007;69(1):91-102. Erratum in: Neurology 2008;70(14):1223. PMID 17522387Marques A. Chronic Lyme disease: a review. Infect Dis Clin North Am 2008;22(2):341-60, vii-viii. PMID 18452806Marques AR. Lyme neuroborreliosis. Continuum (Minneap Minn) 2015;21(6 Neuroinfectious Disease):1729-44. PMID 26633786 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities. Episodes originally aired from 2016 to 2021.Originally released: November 14, 2019The FDA label for ACTEMRA® (tocilizumab)--the first medication approved for use in giant cell arteritis in 2017--is 40 pages long. Of the information provided in this document, which includes important dosing information, dose adjustments based on leukocyte count, clinical trial and epidemiologic data, there is a box of text on the first page of the insert. "WARNING: RISK OF SERIOUS INFECTIONS," it reads.What do you make of this warning? And with such a clear and broad-sweeping statement stamped on the medication, how do you mitigate the medico-legal risk of using this drug?This week on the program we launch into a two-part series focused on some of the events that follow major clinical trials. In part 1, we cover the three major classifications of FDA alerts for medical treatments using two examples from the neurologic pharmacopoeia. In part 2, we emphasize the importance of post-publication peer review. And both are equally instrumental in our medical decision-making.Produced by James E Siegler with the support of Michael Rubenstein (University of Pennsylvania) and Zachary Newcomer (University of Florida). Music courtesy of Coldnoise, Cuicuitte, Doctor Turtle, Jahzzar, and Peter Rudenko under a CC license. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. None of what is discussed here should be misconstrued as medical advice, so don't just go prescribing drugs off-label! (Or willy nilly, as my grandmother might say) Be sure to follow us on Twitter (now X) @brainwavesaudio for the latest updates to the podcast.REFERENCESBallard C, Hanney ML, Theodoulou M, et al. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial. Lancet Neurol 2009;8(2):151-7. PMID 19138567Dorsey ER, Beck CA, Darwin K, et al. Natural history of Huntington disease. JAMA Neurol 2013;70(12):1520-30. PMID 24126537Hubers AA, van Duijn E, Roos RA, et al. Suicidal ideation in a European Huntington's disease population. J Affect Disord 2013;151(1):248-58. PMID 23876196Moore TJ, Singh S, Furberg CD. The FDA and new safety warnings. Arch Intern Med 2012;172(1):78-80. PMID 22232155Rose RV, Kass JS. Prescribing antipsychotic medications to patients with dementia: boxed warnings and mitigation of legal liability. Continuum (Minneap Minn) 2019;25(1):254-9. PMID 30707196Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005;294(15):1934-43. PMID 16234500Schultz JL, Killoran A, Nopoulos PC, Chabal CC, Moser DJ, Kamholz JA. Evaluating depression and suicidality in tetrabenazine users with Huntington disease. Neurology 2018;91(3):e202-7. PMID 29925548Shen V, Clarence-Smith K, Hunter C, Jankovic J. Safety and efficacy of tetrabenazine and use of concomitant medications during long-term, open-label treatment of chorea associated with Huntington's an
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021.Originally released: Jan 18, 2018When it comes to stroke, treatment is dependent on the stroke mechanism. But most patients wind up on aspirin anyway. Or Plavix (clopidogrel). And sometimes both. The question this week is, Why? I hope you're hungry for some fruit because we're comparing a bunch of apples to oranges in this episode of the BrainWaves podcast.Produced by James E Siegler. Music by William Ross Chernoff's Nomads, Steve Combs, Rui, Little Glass Men, and Peter Rudenko. Voiceover by Erika Mejia. BrainWaves' podcasts and online content are intended for medical education only and should not be used for routine clinical decision-making. Even if this episode is all about choosing aspirin or clopidogrel when you're treating stroke patients. Always talk with your doctor, and if you are a doctor, you should rely on institutional policies and your own clinical judgment when treating patients.REFERENCESAntithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324(7329):71-86. Erratum in: BMJ 2002;324(7330):141. PMID 11786451Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006;354(16):1706-17. PMID 16531616CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group. Lancet 1997;349(9066):1641-9. PMID 9186381Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ 1994;308(6921):81-106. Erratum in: BMJ 1994;308(6943):1540. PMID 8298418CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996;348(9038):1329-39. PMID 8918275Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 2004;364(9431):331-7. PMID 15276392Hong KS, Lee SH, Kim EG, et al. Recurrent ischemic lesions after acute atherothrombotic stroke: clopidogrel plus aspirin versus aspirin alone. Stroke 2016;47(9):2323-30. PMID 27418597Jauch EC, Saver JL, Adams HP Jr, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013;44(3):870-947. PMID 23370205Kennedy J, Hill MD, Ryckborst KJ, et al. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol 2007;6(11):961-9.
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 18, 2017 We rely heavily on our vision to perceive the world around us. (You wouldn't even be able to read this unless your vision were fully intact.) But what happens when that visual information is registered poorly by the eyes or the information is erroneously translated by a damaged nervous system? Cognitive neuroscientist and visual systems specialist, Dr. Geoff Aguirre joins in this segment on how structural neurologic injury contributes to abnormalities in visual perception. Produced by James E Siegler & Erika Mejia. Music by MMFFF, Peter Rudenko, Three Chain Links, and Marcos H. Bolanos. Voiceover by Erika Mejia. BrainWaves' podcasts and online content are intended for medical education only and should not be used for routine clinical purposes. REFERENCES Barton JJ. Disorders of higher visual processing. Handb Clin Neurol 2011;102:223-61. PMID 21601069Meadows JC, Munro SS. Palinopsia. J Neurol Neurosurg Psychiatry 1977;40(1):5-8. PMID 845607Podoll K, Robinson D. Lewis Carroll's migraine experiences. Lancet 1999;353(9161):1366. PMID 10218566Radoeva PD, Prasad S, Brainard DH, Aguirre GK. Neural activity within area V1 reflects unconscious visual performance in a case of blindsight. J Cogn Neurosci 2008;20(11):1927-39. PMID 18416678 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 18, 2017 Two weeks ago, Dr. Rubenstein and I discussed one of the difficulties of being a doctor. This week, we're shifting gears, and the focus is now on the patient, particularly the angry patient. Dr. Hamedani shares his experience of being the nicest dude in the world and how he deals with hard-to-deal-with patients. Produced by James E Siegler and Erika Mejia. Music by Peter Rudenko, Steve Combs, and Lovira. Voiceover by Erika Mejia. BrainWaves' podcasts and online content are intended for medical education only and should not be used for routine clinical decision-making. ...But you can probably learn a lot about how to talk with your patients from Dr. Hamedani. So take some notes. He invented the bedside manner. We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
In this episode of Book Nook, Africa Melane chats to Max Price about his book Statues and Storms (Tafelberg, 2023). Statues and Storms offers invaluable insights on leadership during turbulent times. It's a must-read for anyone looking to make a positive impact in a rapidly changing world. This was reflected at the book's launch at Exclusive Books Waterfront, which was packed with eager readers, leaders, and change-makers. The thought-provoking discussion between Africa and Max was unforgettable - and is now available for your listening pleasure! Statues and Storms is available to purchase online or at local bookstores. Music: Snowing by Peter Rudenko, Free Music Archive (CC BY)
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: October 5, 2017 Dr. David Coughlin returns for this week's Teaching Through Clinical Cases to discuss the management of a delirious patient with a hyperkinetic movement disorder. Produced by James E Siegler. Music by Hyson, Josh Woodward, Komiku, and Peter Rudenko. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. REFERENCES Ables AZ, Nagubilli R. Prevention, recognition, and management of serotonin syndrome. Am Fam Physician 2010;81(9):1139-42. PMID 20433130 Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med 2005;352(11):1112-20. PMID 15784664 Dosi R, Ambaliya A, Joshi H, Patell R. Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary. BMJ Case Rep 2014;2014:bcr2014204154. PMID 24957740 Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM 2003;96(9):635-42. PMID 12925718 Lappin RI, Auchincloss EL. Treatment of the serotonin syndrome with cyproheptadine. N Engl J Med 1994;331(15):1021-2. PMID 8084345 Mills KC. Serotonin syndrome. Am Fam Physician 1995;52(5):1475-82. PMID 7572570 Pedavally S, Fugate JE, Rabinstein AA. Serotonin syndrome in the intensive care unit: clinical presentations and precipitating medications. Neurocrit Care 2014;21(1):108-13. PMID 24052457 Radomski JW, Dursun SM, Reveley MA, Kutcher SP. An exploratory approach to the serotonin syndrome: an update of clinical phenomenology and revised diagnostic criteria. Med Hypotheses 2000;55(3):218-24. PMID 10985912 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: July 25, 2019 A 50-year-old gentleman presents with severe headaches and speech disturbance. The MRI shows acute strokes and multifocal vascular irregularities. Is it reversible cerebral vasoconstriction syndrome or primary angiitis of the central nervous system? Or is it something else entirely? RCVS and PACNS almost always pose a challenge--even to the most astute neurologist. But, because they are treated entirely differently and their clinical trajectories depend on these treatments, it is worth knowing how experts distinguish the two. This week on the BrainWaves podcast, Dr. Jesse Thon joins Jim Siegler in a discussion about the clinical and radiographic features of these two conditions and shares his experience in managing these patients. Produced by James E Siegler and Jesse Thon. Music courtesy of Nuno Adelaida, Peter Rudenko on the piano, Squire Tuck on the guitar, Swelling, and Uncanny. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Birnbaum J, Hellmann DB. Primary angiitis of the central nervous system. Arch Neurol 2009;66(6):704-9. PMID 19506130 Miller TR, Shivashankar R, Mossa-Basha M, Gandhi D. Reversible cerebral vasoconstriction syndrome, part 1: epidemiology, pathogenesis, and clinical course. AJNR Am J Neuroradiol 2015;36(8):1392-9. PMID 25593203 Miller TR, Shivashankar R, Mossa-Basha M, Gandhi D. reversible cerebral vasoconstriction syndrome, part 2: Diagnostic work-up, imaging evaluation, and differential diagnosis. AJNR Am J Neuroradiol 2015;36(9):1580-8. PMID 25614476 Rocha EA, Topcuoglu MA, Silva GS, Singhal AB. RCVS2 score and diagnostic approach for reversible cerebral vasoconstriction syndrome. Neurology 2019;92(7):e639-47. PMID 30635475 Singhal AB. Diagnostic challenges in RCVS, PACNS, and other cerebral arteriopathies. Cephalalgia 2011;31(10):1067-70. PMID 21673004 Singhal AB, Topcuoglu MA. Glucocorticoid-associated worsening in reversible cerebral vasoconstriction syndrome. Neurology 2017;88(3):228-36. PMID 27940651 Singhal AB, Topcuoglu MA, Fok JW, et al. Reversible cerebral vasoconstriction syndromes and primary angiitis of the central nervous system: clinical, imaging, and angiographic comparison. Ann Neurol 2016;79(6):882-94. PMID 27043703 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: May 2, 2019 Although he may never have attended university, Leonardo da Vinci (1452-1519) was a true scholar of the Renaissance. His contributions to civil and mechanical engineering, the creative arts, and natural philosophy are nothing short of extraordinary. Less well popularized--although of equal importance--were his accomplishments in the field of anatomy. This week on the BrainWaves Podcast, we delve into his discoveries, his methodology, his handedness, and the message he has left us. Produced by James E Siegler. Music courtesy of Sergey Chereminisov, Peter Rudenko, Fatal Injection, Andrew Sacco, Alavedra Montserrat, William McColl, and Joseph Levine. Sound effects by Mike Koenig, Mark DiAngelo, and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Bowen G, Gonzales J, Iwanaga J, et al. Leonardo da Vinci (1452-1519) and his depictions of the human spine. Childs Nerv Syst 2017;33(12):2067-70. PMID 28283776 Keele KD. Leonardo da Vinci and anatomical demonstration. Med Biol Illus 1952;2(4):226-32. PMID 13012348 Keele KD. Leonardo da Vinci on vision. Proc R Soc Med 1955;48(5):384-90. PMID 14395232 Keele KD. Leonardo Da Vinci's influence on renaissance anatomy. Med Hist 1964;8:360-70. PMID 14230140 Pedretti C, Keele KD. Leonardo Da Vinci: Corpus of the Anatomical Studies in the Collection of Her Majesty the Queen at Windsor Castle. United States: Johnson Reprint Corporation, 1981. Pevsner J. Leonardo da Vinci's contributions to neuroscience. Trends Neurosci 2002;25(4):217-20. PMID 11998691 Pevsner J. Leonardo da Vinci's studies of the brain. Lancet 2019;393(10179):1465-72. PMID 30967217 Schott GD. Some neurological observations on Leonardo da Vinci's handwriting. J Neurol Sci 1979;42(3):321-9. PMID 390099 We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.
Le 25 octobre 2005, un avis de disparition est diffusé partout dans les médias concernant une femme disparue. Elle aurait été vue pour la dernière fois par son conjoint, à 6h25 du matin, au moment où elle quittait son domicile pour se rendre à son travail. Pour connaitre la suite de cette horrible histoire, cliquez juste ici et bonne écoute!♥Viens me suivre sur mes réseaux sociaux♥INSTAGRAM: https://www.instagram.com/ninnielaterreurFACEBOOK: https://www.facebook.com/ninnieLATERREUR.podcastSITE WEB: https://baladoquebec.ca/ninnie-laterreurEMAIL: ninnielaterreur@gmail.comMes sources:https://www.banq.qc.ca/Chanson thème:One Missed Call Ringtone (American Version).Musique d'arrière-plan: Snowing by Peter Rudenko http://freemusicarchive.org/music/Peter_Rudenko Creative Commons — Attribution 3.0 Logiciel de montage:AudacityMontage: xam
The most numerous purely terrestrial animal in Antarctica is almost certainly the nematode worm Scottnema lindsayae. An astonishingly resilient little creature that goes places almost no other animal can, and probably rides the wind to get there ... Subscribe to the show to make sure you don't miss any future Wild Episodes, and e-mail your comments, corrections, suggestions or feedback to help make those future episodes better! You can also follow the show on Facebook or Twitter. To support the show, please share on social media, rate and review in your podcast app! Thank you. Show notes, with photos, video and links to lots more information, are available at thewildepisode.com Music Opening & Closing Themes: Running Waters and Acoustic Meditation by Audionautix (Jason Shaw), from audionautix.com. CC BY 3.0. Modified versions of: Iced Spring Theme and The Fall by Peter Rudenko, CC BY 4.0 and CC BY 3.0 respectively.
Things lost. Things found. Things buried. A stitch can either open or close. Music: Circle of Bones by ROZCOL, Thoughtforms by Evgeni Rogozin, Maio Maduro Maio by Lovira, The Undo Spell by Peter Rudenko, and M, Volume II by (morse). Written by Becca De La Rosa and Mabel Martin. Guest starring: Dorrie Sacks as Janet Kirk and Reina Roman as Lolo Garcia. mabelpodcast.com patreon.com/mabelpodcast
The Yellow-Bellied Sea Snake (Hydrophis platurus) is probably the most widespread snake in the world and, arguably, the most marine of all living marine reptiles. It has cut all ties with the land, and mastered an environment no other sea snake quite has: the open ocean. Subscribe to the show to make sure you don't miss any future Wild Episodes, and e-mail your comments, corrections, suggestions or feedback to help make those future episodes better! You can also follow the show on Facebook or Twitter. Music Opening & Closing Themes: Running Waters and Acoustic Meditation by Audionautix (Jason Shaw), from audionautix.com. CC BY 3.0. Modified versions of: Iced Spring Theme, Slow Motion, Aug 12, The Fall, What Follows Me by Peter Rudenko, CC BY 4.0 Prelude No 1, Prelude No 6 by Chris Zabriskie, CC BY 4.0
The Resolute leave Candlekeep to enter into hell itself in order to save a city that was dragged into it! How do they get to Avernus and what awaits them when they get there?! Following Music used by https://freemusicarchive.org/ Morning by Cambo, Peace Within by Peter Rudenko, Choas by XTaKeRuX, and Shinigami by XTaKeRuX also Forest Walk by Alexander Nakarada (www.serpentsoundstudios.com)
Estamos de volta e neste ano teremos muitas novidades. O episódio narrativo que vocês já conhecem continuará na última quarta-feira do mês, mas além dele teremos outros três encontros semanais. Na primeira quarta do mês, falaremos os lançamentos da editora e nossas novidades. Neste episódio, Ana Paula Hisayama conta quais são nossos destaques de fevereiro.==Links para os livros citados neste episódio:ESFORÇOS OLÍMPICOS: https://todavialivros.com.br/livros/esforcos-olimpicosCOPO VAZIO: https://todavialivros.com.br/livros/copo-vazioGUARDA LUNAR: https://todavialivros.com.br/livros/guarda-lunarVAN GOGH - A SALVAÇÃO PELA PINTURA: https://todavialivros.com.br/livros/van-gogh-a-salvacao-pela-pintura===Produção: Ricardo TertoRoteiro: Carime ElmorRevisão: Ana Paula Hisayama e Ricardo TertoEdição de som: Ricardo TertoArte: Flora PrósperoEste episódio utiliza músicas de Ketsa, Peter Rudenko, Reed Mathis, Dan Bodan e Chris Haugen.
Dette er en særudsendelse fra Mediano, der handler om Maradona og om dyrkelsen af ham. Udsendelsen handler om sport, politik og religion. Den handler også om latinamerikansk, og især argentinsk, kultur. Og så er det altså en nekrolog om Maradona – den menneskeligste af alle guder. Medvirkende: Lektor ved Institut for Kultur og Samfund - Afdeling for Religionsvidenskab, Marianne Qvortrup Fibiger, journalist, Ebbe Fischer, og fodboldantropolog, Lasse Højstrup Sørensen. Tilrettelæggelse: Adam Møller Gomaa Musik: "Snowing" af Peter Rudenko & "Op al den ting, som Gud har gjort" fremført af Anne Dorte Michelsen.
October 29 is World Stroke Day! Might as well know how it is best treated. This week, Jim Siegler revisits a 2017 episode on the differences between two of the most commonly prescribed post-stroke treatments, with some key updates, recent trial results, and practice-changing paradigms. Produced by James E. Siegler. Music courtesy of William Ross Chernoff’s Nomads, Steve Combs, Rui, Little Glass Men, and Peter Rudenko. The opening theme was composed by Jimothy Dalton. Sound effects by Mike Koenig and Daniel Simion. Unless otherwise mentioned in the podcast, no competing financial interests exist in the content of this episode. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Jauch EC, Saver JL, Adams HP, Jr., Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW, Jr., Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H, American Heart Association Stroke C, Council on Cardiovascular N, Council on Peripheral Vascular D and Council on Clinical C. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; a journal of cerebral circulation. 2013;44:870-947. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet. 1997;349:1569-81. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group. Lancet. 1997;349:1641-9. Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM and Investigators F. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. The Lancet Neurology. 2007;6:961-9. Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC and Investigators C. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. The New England journal of medicine. 2013;369:11-9. Hong KS, Lee SH, Kim EG, Cho KH, Chang DI, Rha JH, Bae HJ, Lee KB, Kim DE, Park JM, Kim HY, Cha JK, Yu KH, Lee YS, Lee SJ, Choi JC, Cho YJ, Kwon SU, Kim GM, Sohn SI, Park KY, Kang DW, Sohn CH, Lee J, Yoon BW and Investigators C. Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone. Stroke; a journal of cerebral circulation. 2016;47:2323-30. Liu L, Wong KS, Leng X, Pu Y, Wang Y, Jing J, Zou X, Pan Y, Wang A, Meng X, Wang C, Zhao X, Soo Y, Johnston SC, Wang Y and Investigators C. Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE. Neurology. 2015;85:1154-62. Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. Bmj. 1994;308:81-106. Antithrombotic Trialists C. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Bmj. 2002;324:71-86. Committee CS. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996;348:1329-39. Ringleb PA, Bhatt DL, Hirsch AT, Topol EJ, Hacke W and Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events I. Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events. Stroke; a journal of cerebral circulation. 2004;35:528-32. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matias-Guiu J, Rupprecht HJ and investigators M. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364:331-7. Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE, Cacoub P, Cohen EA, Creager MA, Easton JD, Flather MD, Haffner SM, Hamm CW, Hankey GJ, Johnston SC, Mak KH, Mas JL, Montalescot G, Pearson TA, Steg PG, Steinhubl SR, Weber MA, Brennan DM, Fabry-Ribaudo L, Booth J, Topol EJ and Investigators C. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. The New England journal of medicine. 2006;354:1706-17. Rothwell PM, Price JF, Fowkes FG, Zanchetti A, Roncaglioni MC, Tognoni G, Lee R, Belch JF, Wilson M, Mehta Z and Meade TW. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet. 2012;379:1602-12. Sahlen A, Varenhorst C, Lagerqvist B, Renlund H, Omerovic E, Erlinge D, Wallentin L, James SK and Jernberg T. Outcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction: experiences from SWEDEHEART registry. European heart journal. 2016;37:3335-3342. Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, Heptinstall S, James M, Krishnan K, Markus HS, Montgomery AA, Pocock SJ, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N and Investigators T. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet. 2018;391:850-859. Lopes RD, Heizer G, Aronson R, Vora AN, Massaro T, Mehran R, Goodman SG, Windecker S, Darius H, Li J, Averkov O, Bahit MC, Berwanger O, Budaj A, Hijazi Z, Parkhomenko A, Sinnaeve P, Storey RF, Thiele H, Vinereanu D, Granger CB, Alexander JH and Investigators A. Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation. The New England journal of medicine. 2019;380:1509-1524. Wang Y, Chen W, Lin Y, Meng X, Chen G, Wang Z, Wu J, Wang D, Li J, Cao Y, Xu Y, Zhang G, Li X, Pan Y, Li H, Zhao X, Liu L, Lin J, Dong K, Jing J, Johnston SC, Wang D, Wang Y and Group PPS. Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack: open label, blinded endpoint, randomised controlled phase II trial. Bmj. 2019;365:l2211.
The Wandering Glider (Pantala flavescens) may look like just another dragonfly, but it is in fact one of the more remarkable insects on Earth, undertaking some of the most extraordinary journeys in the entire animal kingdom ... Subscribe to the show to make sure you don't miss any future Wild Episodes, and e-mail your comments, corrections, suggestions or feedback to help make those future episodes better! You can also follow the show on Facebook or Twitter. Music by Audionautix and Mystery Mammal and Siddhartha and Chris Zabriskie and Peter Rudenko. All licensed under Creative Commons Attribution. www.thewildepisode.com
Text: Acts 5:12-17 Music: "Smile On" and "Winter Sun" by Peter Rudenko
Text: Mark 16:14-20 Music: "Forgiven" by Brian Christopher Clay and "Inner Mechanics" by Peter Rudenko
Text: Mark 13: 9-13 Music: "Wings" by Cathy Pino "If" by Peter Rudenko
Text: Psalm 89: 19-29, 38-52 Music: "Wings" by Cathy Pino; "Winter Sun" by Peter Rudenko
Psalm 118:1-6 "Slow Motion- Pt. 1" and "Slow Motion- Pt. 2"- Peter Rudenko https://www.facebook.com/rudenko.peter "Find Rest"- Salt of the Sound https://saltofthesound.com/ www.theartoffaith.net
The FDA label for ACTEMRA (tocilizumab)--the first medication approved for use in giant cell arteritis in 2017--is 40 pages long. Of the information provided in this document, which includes important dosing information, dose adjustments based on leukocyte count, clinical trial and epidemiologic data, there is a box of text on the first page of the insert. "WARNING: RISK OF SERIOUS INFECTIONS" it reads. What do you make of this warning? And with such a clear and broad-sweeping statement stamped on the medication, how do you mitigate the medico-legal risk for using this drug? This week on the program we launch into a 2-part series focused on some of the events which follow major clinical trials. In part 1, we cover the 3 major classifications of FDA alerts for medical treatments using 2 examples from the neurologic pharmacopoeia. In part 2, we emphasize the importance of post-publication peer review. And both are equally instrumental in our medical decision making. Produced by James E. Siegler with the support of Michael Rubenstein (University of Pennsylvania) and Zachary Newcomer (University of Florida). Music courtesy of Coldnoise, Cuicuitte, Doctor Turtle, Jahzzar, and Peter Rudenko under a CC license. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. None of what is discussed here should be misconstrued as medical advice, so don't just go prescribing drugs off-label! (Or willy nilly, as my grandmother might say) Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Schneider LS, Dagerman KS and Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA : the journal of the American Medical Association. 2005;294:1934-43. Ballard C, Hanney ML, Theodoulou M, Douglas S, McShane R, Kossakowski K, Gill R, Juszczak E, Yu LM, Jacoby R and investigators D-A. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial. The Lancet Neurology. 2009;8:151-7. Moore TJ, Singh S and Furberg CD. The FDA and new safety warnings. Archives of internal medicine. 2012;172:78-80. Dorsey ER, Beck CA, Darwin K, Nichols P, Brocht AF, Biglan KM, Shoulson I and Huntington Study Group CI. Natural history of Huntington disease. JAMA Neurol. 2013;70:1520-30. Hubers AA, van Duijn E, Roos RA, Craufurd D, Rickards H, Bernhard Landwehrmeyer G, van der Mast RC, Giltay EJ and Network RiotEHsD. Suicidal ideation in a European Huntington's disease population. J Affect Disord. 2013;151:248-58. Shen V, Clarence-Smith K, Hunter C and Jankovic J. Safety and Efficacy of Tetrabenazine and Use of Concomitant Medications During Long-Term, Open-Label Treatment of Chorea Associated with Huntington's and Other Diseases. Tremor Other Hyperkinet Mov (N Y). 2013;3. Schultz JL, Killoran A, Nopoulos PC, Chabal CC, Moser DJ and Kamholz JA. Evaluating depression and suicidality in tetrabenazine users with Huntington disease. Neurology. 2018;91:e202-e207. Rose RV and Kass JS. Prescribing Antipsychotic Medications to Patients With Dementia: Boxed Warnings and Mitigation of Legal Liability. Continuum (Minneap Minn). 2019;25:254-259. US Food and Drug Administration. Guidance for industry: warnings and precautions, contraindications, and boxed warning sections of labeling for human prescription drug and biological products—content and format. www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm075096.pdf. Published October 2011. Accessed 11 July 2019.
"It was that sense of loss like an oak tree had just, gone!"What happens when you grow up and work in the shadow of a hugely successful, driven ,figurehead father? And what happens when that person you loved is gone?How does this shape you as a person? And how do you adapt and change your life?In this weeks Episode we delve into the high octane, boom and bust world of big business, venture capital and start ups with my guest Jane Murray.Jane is a trained lawyer, investment fund manager, restaurant owner and now CEO of Peacebeam a start up dedicated to bringing small acts of kindness into our world.So how did Jane transform from a world of masculine egos, high stress ,risk and reward to a business that is quite honestly the antithesis of the business world she spent 20 odd years in?In our conversation we explore the motivations and mindsets which sat behind this transformation and the forces that are driving change in the way society is starting to view work and success.Jane also goes on to talk about the values that were instilled in her as a child and how that helped her to cope with the sometimes chaotic circumstances of her life and the adversity she faced, ultimately providing her with the grounding which was the foundation of the change in her life.And finally we hear about her new venture Peacebeam and it's mission to bring a little calm and kindness into the world.Listen and share your thoughts and observations with the Turning the Tables community on Facebook at;https://l.facebook.com/l.php?u=https%3A%2F%2Ffb.me%2Fratcliffe2019&h=AT0X0mPTGiX_FLw6tFW8fTWlDwXAcHNMbFLsZ1IjBrK3mVKYpKt-vUZUnyqC9oU5iAZBSKBjNLQMXg8_zjPcjpEHZ9Qhwk3aGcaOKq8mW8muNM-6vFiJ9V2rNEkcDtds84-JlcQFbLgYou can find out more about Peacebeam and contact Jane through email: jane@peacebeam.comEpisode credits;Editor and sound engineer : Tim White email: showupnow@gmail.comMusic : Broken Elegance -Unconditionallyhttps://www.youtube.com/redirect?v=aH95sxn7HS8&event=video_description&redir_token=6ehCbtIu30AhxC4UJc33VENytGF8MTU2MzE4ODY1M0AxNTYzMTAyMjUz&q=https%3A%2F%2Fsoundcloud.com%2FbrokeneleganceMusic :5:00 AM by Peter Rudenko http://freemusicarchive.org/music/Peter_Rudenko Creative Commons — Attribution 3.0 Unported— CC BY 3.0 Free Download / Stream: https://bit.ly/5-00-am Music promoted by Audio Library https://youtu.be/uAg2KMC7toI
This is PART ONE of a TWO PART episode which concludes next week.On Monday 7th April 1924, Emily Beilby Kaye; a smart independent lady who felt her last chance of wedding bells and babies had her slipped-by, left her apartment at the Green Cross Club at 68 Guilford Street, WC1, having met an Irish rogue called “Pat”. And although this tawdry affair would lead to her death…it also led to one of the most significant innovations in murder investigations.Murder Mile UK True-Crime Podcast is researched, written and performed by Michael J Buchanan-Dunne of Murder Mile Walks with music written and performed by Erik Stein and Jon Boux of Cult With No Name with additional music by Peter Rudenko, NCTRNM and Seclorance, as used under the Creative Commons License 4.0 (Attribution) via Free Music Archive. A full listing of tracks used and sources for each episode is listed below.FOLLOW US HERE:FacebookTwitterInstagramMurder Mile Discussion GroupClick here to access the weekly Murder Mile BlogsIf you’d like to sign-up for exclusive Murder Mile content, check out our Patreon PageAnd for OFFICIAL MERCHANDISE, please visit the Murder Mile Shop. See acast.com/privacy for privacy and opt-out information.
A 50-year-old gentleman presents with severe headaches and speech disturbance. The MRI shows acute strokes and multifocal vascular irregularities. Is it reversible cerebral vasoconstriction syndrome or primary angiitis of the central nervous system? Or is it something else entirely? RCVS and PACNS almost always pose a challenge--even to the most astute neurologist. But, because they are treated entirely differently and their clinical trajectories depend on these treatments, it is worth knowing how experts distinguish the two. This week on the BrainWaves podcast, Dr. Jesse Thon joins Jim Siegler in a discussion about the clinical and radiographic features of these two conditions, and shares his experience in managing these patients. Produced by James E. Siegler and Jesse Thon. Music courtesy of Nuno Adelaida, Peter Rudenko on the piano, Squire Tuck on the guitar, Swelling, and Uncanny. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Singhal AB. Diagnostic challenges in RCVS, PACNS, and other cerebral arteriopathies. Cephalalgia. 2011;31:1067-70. Miller TR, Shivashankar R, Mossa-Basha M and Gandhi D. Reversible Cerebral Vasoconstriction Syndrome, Part 2: Diagnostic Work-Up, Imaging Evaluation, and Differential Diagnosis. AJNR American journal of neuroradiology. 2015;36:1580-8. Miller TR, Shivashankar R, Mossa-Basha M and Gandhi D. Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical Course. AJNR American journal of neuroradiology. 2015;36:1392-9. Singhal AB, Topcuoglu MA, Fok JW, Kursun O, Nogueira RG, Frosch MP and Caviness VS, Jr. Reversible cerebral vasoconstriction syndromes and primary angiitis of the central nervous system: clinical, imaging, and angiographic comparison. Annals of neurology. 2016;79:882-94. Singhal AB and Topcuoglu MA. Glucocorticoid-associated worsening in reversible cerebral vasoconstriction syndrome. Neurology. 2017;88:228-236. Rocha EA, Topcuoglu MA, Silva GS and Singhal AB. RCVS2 score and diagnostic approach for reversible cerebral vasoconstriction syndrome. Neurology. 2019;92:e639-e647. Birnbaum J and Hellmann DB. Primary angiitis of the central nervous system. Archives of neurology. 2009;66:704-9.
Although he may never have attended university, Leonardo da Vinci (1452-1519) was a true scholar of the Renaissance. His contributions to civil and mechanical engineering, the creative arts, and natural philosophy are nothing short of extraordinary. Less well popularized--although of equal importance--were his accomplishments in the field of anatomy. This week on the BrainWaves Podcast, we delve into his discoveries, his methodology, his handedness, and the message he has left us with. IF YOU'RE TAKING YOUR NEUROLOGY BOARDS, and not sure how to prepare, check out the 2019 Penn Neurology Board Review Course here [https://upenn.cloud-cme.com/default.aspx?P=5&EID=54399]. If Leonardo da Vinci had gone to school, he would have liked this course. BrainWaves' listeners get $150 off their enrollment fee using the promo code 'WAVES2019'. Produced by James E. Siegler. Music courtesy of Sergey Chereminisov, Peter Rudenko, Fatal Injection, Andrew Sacco, Alavedra Montserrat, William McColl, and Joseph Levine. Sound effects by Mike Koenig, Mark DiAngelo, and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Keele KD. Leonardo da Vinci and anatomical demonstration. Med Biol Illus. 1952;2(4):226-232. Keele KD. Leonardo da Vinci on vision. Proc R Soc Med. 1955;48(5):384-390. Keele KD. Leonardo Da Vinci's Influence on Renaissance Anatomy. Med Hist. 1964;8:360-370. Schott GD. Some neurological observations on Leonardo da Vinci's handwriting. Journal of the neurological sciences. 1979;42(3):321-329. Pevsner J. Leonardo da Vinci's contributions to neuroscience. Trends Neurosci. 2002;25(4):217-220. Bowen G, Gonzales J, Iwanaga J, et al. Leonardo da Vinci (1452-1519) and his depictions of the human spine. Childs Nerv Syst. 2017;33(12):2067-2070. Pevsner J. Leonardo da Vinci's studies of the brain. Lancet. 2019;393(10179):1465-1472. Leonardo da Vinci. Corpus of the anatomical studies in the collection of Her Majesty, the Queen, at Windsor Castle. (Clark K., and Pedretti, C., eds.), 39 Recto, Harcourt Brace Janovich.
In this episode we read an Easter story by Abbie Phillips Walker about a silly little hen who just can't believe her eyes. Theme music by Komiku with background by Peter Rudenko.| Follow us on Twitter @readonpodcast
Moon and mirror. Flesh and bone. Reality and fiction. Then and now. Before and after. Is and is not. Journalist and florist. World and world. Featuring: who are these voices, again? Are we meant to recognize them? Are we meant to know their names? Where are we? What have we done? Music: Why Don't You Write When You Don't Need Money by Bob Roberts, Stay 17 by Peter Rudenko, Precisamos de um plano by rui, and M, Volume II by (morse). Written by Becca De La Rosa and Mabel Martin. patreon.com/mabelpodcast mabelpodcast.com
00:00 Gary War - "Grounds For Termination (Phil Gone Mix)" 03:22 Bryan Mathys - "Hard Miles" 07:00 Daniel Veesey - "Sonata No. 1 in F Minor, Op. 2 No. 1 - II. Adagio" 12:34 Daddy Long Legs - "Mornin', Noon & Nite" 14:51 Jonas - "Monkeytail" 18:29 REW - "Distance From Vultures (INSTRUMENTAL)" 20:09 Peter Rudenko - "Aug '12" All music sourced from the Free Music Archive under Creative Commons licenses. Info, licenses, and downloads: Grounds For Termination (Phil Gone Mix) Hard Miles Sonata No. 1 in F Minor, Op. 2 No. 1 - II. Adagio Mornin', Noon & Nite Monkeytail Distance From Vultures (INSTRUMENTAL) Aug '12
On 30th December 1942, in 112 Bryanston Court, Marion Lees-Smith was a single mother who was struggling alone to cope with the daily demands of Derek - her deaf and brain-damaged son. And as frustrated and exasperated as Marion would often be, her death would come about, not by exhaustion, but by the hand of her own son.Nominated one of the BEST BRITISH TRUE CRIME PODCASTS of 2018, Murder Mile is a true-crime podcast and audio-guided walk of 300+ untold, unsolved and long-forgotten murder cases, all set within one square mile of the West End. Each episode is accompanied by photos, videos and an interactive murder map, so that no matter where you’re listening to this podcast, you’ll feel like you’re actually there. https://www.murdermiletours.com/podcast.htmlMurder Mile is researched, written and performed by Michael J Buchanan-Dunne of Murder Mile Walks with music written and performed by Erik Stein and Jon Boux of Cult With No Name with additional music by Peter Rudenko, Ars Sonor, Lee Rosevere and Kai Engel, as used under the Creative Commons Licence 4.0 (Attribution) via Free Music Archive. A full listing of tracks used and sources for each episode is listed here.Warning: Murder Mile contains graphic descriptions of murder as well as very realistic sounds which some listeners may find shocking. Thank you and enjoy the episode.FOLLOW US HERE:FacebookTwitterInstagramMurder Mile Discussion GroupFor a transcript of each episode, click here. If you’d like to sign-up for exclusive Murder Mile content, check out our Patreon Page by CLICKING HERE. And for OFFICIAL MERCHANDISE, please visit the Murder Mile Shop. See acast.com/privacy for privacy and opt-out information.
On Tuesday 26th January 1943, somewhere at the back of King’s Cross station, in an unknown derelict warehouse, Glyndwr Michael; a nobody, a nothing, a homeless man became a hero, and although he saved my life, your life and all of our lives, 80 years on, his name his hardly known.Nominated one of the BEST BRITISH TRUE CRIME PODCASTS of 2018, Murder Mile is a true-crime podcast and audio-guided walk of 300+ untold, unsolved and long-forgotten murder cases, all set within one square mile of the West End. Each episode is accompanied by photos, videos and an interactive murder map, so that no matter where you’re listening to this podcast, you’ll feel like you’re actually there. https://www.murdermiletours.com/podcast.htmlMurder Mile is researched, written and performed by Michael J Buchanan-Dunne of Murder Mile Walks with music written and performed by Erik Stein and Jon Boux of Cult With No Name with additional music by Peter Rudenko and Kai Engel, as used under the Creative Commons License 4.0 (Attribution) via Free Music Archive. A full listing of tracks used and sources for each episode is listed here.Warning: Murder Mile contains graphic descriptions of murder as well as very realistic sounds which some listeners may find shocking. Thank you and enjoy the episode.FOLLOW US HERE:FacebookTwitterInstagramMurder Mile Discussion GroupFor a transcript of each episode, click here. If you’d like to sign-up for exclusive Murder Mile content, check out our Patreon Page by CLICKING HERE. And for OFFICIAL MERCHANDISE, please visit the Murder Mile Shop.Here’s also a link to the No Remorse blog as mentioned. See acast.com/privacy for privacy and opt-out information.
Jacques Adrian Tratsart - The Corner House Killer: On Friday 20th April 1945, at the Lyon’s Corner House tearoom on Oxford Street, 27 year old Jacques Tratsart attempted to murder his mild-mannered father, his epileptic sister, his disabled brother and then himself. But what drove this hard-working and ambition man to commit mass-murder?Nominated BEST BRITISH TRUE CRIME PODCAST 2018, Murder Mile is a true-crime podcast and audio-guided walk of 300+ untold, unsolved and long-forgotten murder cases, all set within one square mile of the West End. Each episode is accompanied by photos, videos and an interactive murder map, so that no matter where you’re listening to this podcast, you’ll feel like you’re actually there. https://www.murdermiletours.com/podcast.htmlMurder Mile is researched, written and performed by Michael J Buchanan-Dunne of Murder Mile Walks with music written and performed by Erik Stein and Jon Boux of Cult With No Name with additional music by Kai Engel, Philip Weigl, Rozkol, Swelling, Controlled Insanity and Peter Rudenko, as used under the Creative Commons Licence 4.0 (Attribution) via Free Music Archive. A full listing of tracks used is on the script transcript and sources for each episode, as listed here.Warning: Murder Mile contains graphic descriptions of murder as well as very realistic sounds which some listeners may find shocking. Thank you and enjoy the episode.FOLLOW US HERE:FacebookTwitterInstagramMurder Mile Discussion GroupFor a transcript of each episode, click here. If you’d like to sign-up for exclusive Murder Mile content, check out our Patreon Page by CLICKING HERE. And for OFFICIAL MERCHANDISE, please visit the Murder Mile Shop. See acast.com/privacy for privacy and opt-out information.
The Blackout Ripper Part 8 (of 8): Who was Gordon Frederick Cummins? What incidents in his childhood made him kill? And why would he go on to murder four women in four days in London's West End? Find out in this exploration of the childhood, career, loves and personality of The Blackout Ripper. Murder Mile is a true-crime podcast and audio-guided walk of 300+ untold, unsolved and long-forgotten murder cases, all set within one square mile of the West End. Each episode is accompanied by photos, videos and an interactive murder map, so that no matter where you’re listening to this podcast, you’ll feel like you’re actually there. https://www.murdermiletours.com/podcast.htmlMurder Mile is researched, written and performed by Michael J Buchanan-Dunne of Murder Mile Walks with music written and performed by Erik Stein and Jon Boux of Cult With No Name with additional music by Kai Engel, Philip Weigl, Chris Zabriski, United States Army Old Guard and Peter Rudenko, as used under the Creative Commons Licence 4.0 (Attribution) via Free Music Archive. A full listing of tracks used is on the script transcript and sources for each episode, as listed here.Follow us here:FacebookTwitterInstagramMurder Mile Discussion Group For a transcript of each episode, click here. If you’d like to sign-up for exclusive Murder Mile content, check out our Patreon Page by CLICKING HERE. And for OFFICIAL MERCHANDISE, please visit the Murder Mile Shop. See acast.com/privacy for privacy and opt-out information.
When it comes to stroke, treatment is dependent on the stroke mechanism. But most patients wind up on aspirin anyway. Or Plavix (clopidogrel). And sometimes both. The question this week is, Why? Hope you're hungry for some fruit. We're comparing a bunch of apples to oranges in this episode of the BrainWaves podcast. Produced by James E. Siegler. Music by William Ross Chernoff's Nomads, Steve Combs, Rui, Little Glass Men, and Peter Rudenko. Voiceover by Erika Mejia. BrainWaves' podcasts and online content are intended for medical education only and should not be used for routine clinical decision making. Even if this episode is all about choosing aspirin or clopidogrel when you're treating stroke patients. Always talk with your doctor, and if you are a doctor, you should rely on institutional policies and your own clinical judgment when treating patients. REFERENCES Jauch EC, Saver JL, Adams HP, Jr., Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW, Jr., Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H, American Heart Association Stroke C, Council on Cardiovascular N, Council on Peripheral Vascular D and Council on Clinical C. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; a journal of cerebral circulation. 2013;44:870-947. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet. 1997;349:1569-81. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group. Lancet. 1997;349:1641-9. Kennedy J, Hill MD, Ryckborst KJ, Eliasziw M, Demchuk AM, Buchan AM and Investigators F. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. The Lancet Neurology. 2007;6:961-9. Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, Wang C, Li H, Meng X, Cui L, Jia J, Dong Q, Xu A, Zeng J, Li Y, Wang Z, Xia H, Johnston SC and Investigators C. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. The New England journal of medicine. 2013;369:11-9. Hong KS, Lee SH, Kim EG, Cho KH, Chang DI, Rha JH, Bae HJ, Lee KB, Kim DE, Park JM, Kim HY, Cha JK, Yu KH, Lee YS, Lee SJ, Choi JC, Cho YJ, Kwon SU, Kim GM, Sohn SI, Park KY, Kang DW, Sohn CH, Lee J, Yoon BW and Investigators C. Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone. Stroke; a journal of cerebral circulation. 2016;47:2323-30. Liu L, Wong KS, Leng X, Pu Y, Wang Y, Jing J, Zou X, Pan Y, Wang A, Meng X, Wang C, Zhao X, Soo Y, Johnston SC, Wang Y and Investigators C. Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE. Neurology. 2015;85:1154-62. Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. Bmj. 1994;308:81-106. Antithrombotic Trialists C. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Bmj. 2002;324:71-86. Committee CS. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996;348:1329-39. Ringleb PA, Bhatt DL, Hirsch AT, Topol EJ, Hacke W and Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events I. Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events. Stroke; a journal of cerebral circulation. 2004;35:528-32. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matias-Guiu J, Rupprecht HJ and investigators M. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364:331-7. Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE, Cacoub P, Cohen EA, Creager MA, Easton JD, Flather MD, Haffner SM, Hamm CW, Hankey GJ, Johnston SC, Mak KH, Mas JL, Montalescot G, Pearson TA, Steg PG, Steinhubl SR, Weber MA, Brennan DM, Fabry-Ribaudo L, Booth J, Topol EJ and Investigators C. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. The New England journal of medicine. 2006;354:1706-17. Rothwell PM, Price JF, Fowkes FG, Zanchetti A, Roncaglioni MC, Tognoni G, Lee R, Belch JF, Wilson M, Mehta Z and Meade TW. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet. 2012;379:1602-12.
Dr. David Coughlin returns for this week's Teaching Through Clinical Cases to discuss the management of a delirious patient with a hyperkinetic movement disorder. Produced by James E. Siegler. Music by Hyson, Josh Woodward, Komiku and Peter Rudenko. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. REFERENCES Mills KC. Serotonin syndrome. American family physician. 1995;52:1475-1482 Radomski J, Dursun S, Reveley M, Kutcher S. An exploratory approach to the serotonin syndrome: An update of clinical phenomenology and revised diagnostic criteria. Medical hypotheses. 2000;55:218-224 Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The hunter serotonin toxicity criteria: Simple and accurate diagnostic decision rules for serotonin toxicity. QJM : monthly journal of the Association of Physicians. 2003;96:635-642 Boyer EW, Shannon M. The serotonin syndrome. The New England journal of medicine. 2005;352:1112-1120 Dosi R, Ambaliya A, Joshi H, Patell R. Serotonin syndrome versus neuroleptic malignant syndrome: A challenging clinical quandary. BMJ case reports. 2014;2014:bcr2014204154 Lappin RI, Auchincloss EL. Treatment of the serotonin syndrome with cyproheptadine. The New England journal of medicine. 1994;331:1021-1022 Pedavally S, Fugate JE, Rabinstein AA. Serotonin syndrome in the intensive care unit: Clinical presentations and precipitating medications. Neurocritical care. 2014;21:108-113 Ables AZ, Nagubilli R. Prevention, recognition, and management of serotonin syndrome. American family physician. 2010;81:1139-1142
We rely heavily on our vision to perceive the world around us. (You wouldn't even be able to read this unless your vision were fully intact.) But what happens when that visual information is registered poorly by the eyes, or the information is erroneously translated by a damaged nervous system? Cognitive neuroscientist and visual systems specialist, Dr. Geoff Aguirre joins in this segment on how structural neurologic injury contributes to abnormalities in visual perception. Produced by James E. Siegler & Erika Mejia. Music by MMFFF, Peter Rudenko, Three Chain Links, and Marcos H. Bolanos. Voiceover by Erika Mejia. BrainWaves' podcasts and online content are intended for medical education only and should not be used for routine clinical purposes. REFERENCES Barton JJ. Disorders of higher visual processing. Handbook of clinical neurology. 2011;102:223-61. Meadows JC and Munro SS. Palinopsia. Journal of neurology, neurosurgery, and psychiatry. 1977;40:5-8. Radoeva PD, Prasad S, Brainard DH and Aguirre GK. Neural activity within area V1 reflects unconscious visual performance in a case of blindsight. J Cogn Neurosci. 2008;20:1927-39. Podoll K and Robinson D. Lewis Carroll's migraine experiences. Lancet. 1999;353:1366.
Two weeks ago, Dr. Rubenstein and I talked about one of the difficulties of being a doctor. This week, we're shifting gears and the focus is now on the patient. In particular, the angry patient. Dr. Hamedani shares his experience at being the nicest dude in the world, and how he deals with hard-to-deal-with patients. Produced by James E. Siegler and Erika Mejia. Music by Peter Rudenko, Steve Combs, and Lovira. Voiceover by Erika Mejia. BrainWaves' podcasts and online content are intended for medical education only and should not be used for routine clinical decision making. ...But you can probably learn a lot about how to talk with your patients from Dr. Hamedani. So take some notes. He invented the bedside manner.
All you need to know about CNS Lyme disease in 10 minutes or less. More to come in a few weeks when Dr. Colin Quinn shares his experience with what was "definitely not Lyme disease." Stay tuned. Produced by James E. Siegler. Music by Josh Woodward, Chris Zabriskie, Peter Rudenko, Advent Chamber Orchestra. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision making. REFERENCES Marques A. Chronic Lyme disease: a review. Infect Dis Clin North Am. 2008;22:341-60, vii-viii. Marques AR. Lyme Neuroborreliosis. Continuum (Minneap Minn). 2015;21:1729-44. Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp L, Gronseth G, Bever CT, Jr. and Quality Standards Subcommittee of the American Academy of N. Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2007;69:91-102.
Dette er en pilot test på at prøve at lave en podcast der har "eventyr" som tema! Konceptet er at gode venner sætter sig ned og improvisere sig igennem et planlagt eventyr... Det kan måske lyder lidt spøjst, men giv det et lyt og se hvad du synes :) Baggrundsmusik: "Iced Spring Theme" by Peter Rudenko is licensed under a Attribution License. http://freemusicarchive.org/music/Peter_Rudenko/Inner_Mechanics/Iced_Spring_Theme "Dance of the Sugar Plum Fairies", "Dance of the Sugar Plum Fairy", "We Wish you a Merry Christmas" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/by/3.0/
Hi ACC-tion heroes! Put down that egg nog and turn down "This Christmas," it's time for a really quick Holiday Special. And this one has nothing to do with comics, but it would make a pretty good web comic. Marty went on a trip last week because of a letter he wrote. It's a pretty cool story, bruh. Make sure you head over to All Comics Considered to check out some of the pictures from that trip to the East Wing! Holiday Music: Snowing, by Peter Rudenko. Facebook Page.
Dette er en pilot test på at prøve at lave en podcast der har "eventyr" som tema! Konceptet er at gode venner sætter sig ned og improvisere sig igennem et planlagt eventyr... Det kan måske lyder lidt spøjst, men giv det et lyt og se hvad du synes :) Baggrundsmusik: "Iced Spring Theme" by Peter Rudenko is licensed under a Attribution License. freemusicarchive.org/music/Peter_Ru…d_Spring_Theme
Dette er en pilot test på at prøve at lave en podcast der har "eventyr" som tema! Konceptet er at gode venner sætter sig ned og improvisere sig igennem et planlagt eventyr... Det kan måske lyder lidt spøjst, men giv det et lyt og se hvad du synes :) Baggrundsmusik: "Fairytale Waltz", "Canon in D Major" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 creativecommons.org/licenses/by/3.0/ "Iced Spring Theme" by Peter Rudenko is licensed under a Attribution License. freemusicarchive.org/music/Peter_Ru…d_Spring_Theme
Dette er en pilot test på at prøve at lave en podcast der har "eventyr" som tema! Konceptet er at gode venner sætter sig ned og improvisere sig igennem et planlagt eventyr... Det kan måske lyder lidt spøjst, men giv det et lyt og se hvad du synes :) Baggrundsmusik: "Fairytale Waltz", "Manic Polka" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 creativecommons.org/licenses/by/3.0/ "Iced Spring Theme" by Peter Rudenko is licensed under a Attribution License. freemusicarchive.org/music/Peter_Ru…d_Spring_Theme
On Changing Denver this month, we have the story of Hungarian Freedom Park. What is the connection between Hungary, landscape architecture, and our Queen City of the Plains? More generally, how does a people forge a lasting connection to a place? You can hear the answers to these questions and much more in this, our most ambitious and personal episode to date. - Materials Referenced in this Episode: Here are some links to S.R. DeBoer’s plans for Alamo Placita Park (1927) and what became Hungarian Freedom Park (1925) Here is a copy of the Hungarian Club of Colorado’s founding charter from 1963. Here is a copy of the ordnance that officially changed the park’s name. - Extras: This is the Denver Parks and Recreation Dept.’s current policy on naming and renaming parks. - Music: Our theme song is “Minnow” by Felix Fast4ward. You can find more of his music on Soundcloud. The song we played under the end credits is “Hatcher Creek” by Strawberry Runners. You can find more about them on their website or Facebook. They are headlining a show at the Larimer Lounge on 1 April, and you may see some of the Changing Denver team there, if you’d like to say hi or talk to us about Hungarian Freedom Park. We found the other music for this episode on WFMU’s Free Music Archive. The tracks were “Gagool” and “Trio for Piano Violin and Viola” by Kevin MacLeod, and “Peace Within” and “Snowing” by Peter Rudenko. - You can keep up with Changing Denver by signing up for our newsletter or by following us on Twitter, @changingdenver. Looking for a way to support the show? Rate us on iTunes or Stitcher! Quality reviews will help us reach a wider audience. Thanks for listening!