Infectious tropical disease
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We found out, earlier this week, that Buruli ulcer, caused by a flesh-eating bacteria has settled into a coastal town in NSW. Experts say there’s a significant risk that the bacteria could spread to Sydney, and beyond. Today, health editor Kate Aubusson on how we can stay safe from this disease, which has already gained a foothold in Victoria.Subscribe to The Age & SMH: https://subscribe.smh.com.au/See omnystudio.com/listener for privacy information.
We found out, earlier this week, that Buruli ulcer, caused by a flesh-eating bacteria has settled into a coastal town in NSW. Experts say there’s a significant risk that the bacteria could spread to Sydney, and beyond. Today, health editor Kate Aubusson on how we can stay safe from this disease, which has already gained a foothold in Victoria.Subscribe to The Age & SMH: https://subscribe.smh.com.au/See omnystudio.com/listener for privacy information.
Join the Radiotherapy team Miss Peri Neum and Training Wheels, as they discuss elite sport holistic care with specialist physiotherapist Dr Leanne Rath, in light of the Paris 2024 Olympics. The episode takes a slightly different direction as Associate Professor Dr Daniel O'Brien, Director of the Department of Infectious Diseases at Barwon Health speaks on the Buruli Ulcer, spotlighting what it is and how to treat it.
This week, Catriona celebrates Valentine's Day the science way, showing what research on monogamous prairie voles can tell us about how hormones like dopamine and vasopressin affect our craving for love and affection; and Chris shares new research that suggests the bacteria that causes Buruli ulcer is spread between possums and humans by mosquitoes, and how to protect yourself from it.Lim et al. 2004, Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene, https://doi.org/10.1038/nature02539Amadei et al. 2017, Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles, https://doi.org/10.1038/nature22381Pierce et al. 2024, Nucleus accumbens dopamine release reflects the selective nature of pair bonds, https://doi.org/10.1016/j.cub.2023.12.041Mee et al. 2024, Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia, https://doi.org/10.1038/s41564-023-01553-1
Ulcère de Buruli, bilharziose, filariose lymphatique, maladie du sommeil ou lèpre... Ces maladies font partie des 21 Maladies Tropicales Négligées (MTN) recensées par l'OMS, et qui touchent plus d'un milliard de personnes. Ces maladies sévissent dans les zones où l'accès à des services de santé de qualité, à l'eau potable et aux moyens d'assainissement est difficile. Quelles sont les caractéristiques des maladies tropicales négligées ? Dans quel environnement vivent les populations qui sont touchées par ces maladies ? Quelles MTN ont de bonnes chances d'être éradiquées pour 2030 ? Dr Philippe Solano, directeur de recherche à l'Institut de Recherche pour le développement (IRD) et directeur de l'Unité de Recherche « INTERTRYP » à Montpellier qui associe IRD et CiradRetrouvez l'émission en entier ici :Journée Mondiale des Maladies Tropicales Négligées
Ulcère de Buruli, bilharziose, filariose lymphatique, maladie du sommeil ou lèpre... Ces maladies font partie des 21 Maladies Tropicales Négligées recensées par l'OMS, et qui touchent plus d'un milliard de personnes. Ces maladies sévissent dans les zones où l'accès à des services de santé de qualité, à l'eau potable et aux moyens d'assainissement est difficile. Quelles sont les caractéristiques de ces maladies ? Comment les prévenir ? Est-il possible de les éradiquer ? Et, où en est la recherche ? Existe-t-il des progrès dans la prise en charge de certaines de ces pathologies ? Dr Wilfried Mutombo Kalonji, chef des opérations cliniques de la RDC pour DNDi, une ONG de développement de médicaments pour les maladies tropicales négligées Dr Philippe Solano, directeur de recherche à l'Institut de Recherche pour le développement (IRD) et directeur de l'Unité de Recherche « INTERTRYP » à Montpellier qui associe IRD et Cirad Laurent Marsollier, directeur de Recherche à l'Inserm.► En fin d'émission, Thierry Peyrard, directeur du Département national de référence en immuno-hématologie et sang rare à l'Établissement Français du Sang (EFS) nous parle de la troisième édition de la semaine de sensibilisation aux groupes sanguins rares.Programmation musicale : ► Davido – Feel it► Zaho de Sagazan – La symphonie des éclairs.
Ulcère de Buruli, bilharziose, filariose lymphatique, maladie du sommeil ou lèpre... Ces maladies font partie des 21 Maladies Tropicales Négligées recensées par l'OMS, et qui touchent plus d'un milliard de personnes. Ces maladies sévissent dans les zones où l'accès à des services de santé de qualité, à l'eau potable et aux moyens d'assainissement est difficile. Quelles sont les caractéristiques de ces maladies ? Comment les prévenir ? Est-il possible de les éradiquer ? Et, où en est la recherche ? Existe-t-il des progrès dans la prise en charge de certaines de ces pathologies ? Dr Wilfried Mutombo Kalonji, chef des opérations cliniques de la RDC pour DNDi, une ONG de développement de médicaments pour les maladies tropicales négligées Dr Philippe Solano, directeur de recherche à l'Institut de Recherche pour le développement (IRD) et directeur de l'Unité de Recherche « INTERTRYP » à Montpellier qui associe IRD et Cirad Laurent Marsollier, directeur de Recherche à l'Inserm.► En fin d'émission, Thierry Peyrard, directeur du Département national de référence en immuno-hématologie et sang rare à l'Établissement Français du Sang (EFS) nous parle de la troisième édition de la semaine de sensibilisation aux groupes sanguins rares.Programmation musicale : ► Davido – Feel it► Zaho de Sagazan – La symphonie des éclairs.
We managed to make it through 2023 without a major epidemic or pandemic, and as we get into the holiday spirit and look forward to the new year, some of us took a look back and picked out one of our favorite JCM paper published in 2023, which I will tell you, was no easy task as there were many of good ones to choose from! And personally, after looking through all the issues over the last year, it never ceases to amaze me the variety of topics that we publish on in JCM – including unique things like the evaluation of a molecular assay for diagnosis of Buruli ulcers, to development of an EIA for detection of Taenia coproantigen, and then of course we have the more bread and butter things like evaluation of new assays for detection of TB resistance, to multiple studies this year on women's health diagnostics, and evaluation of new molecular assays for congenital CMV detection, and then I'm also told that there were some awesome AST-focused papers too, which is all just great. The four of us JCM editors have selected the following favorite papers of ours from the past year: Whole-Genome Subtyping Reveals Population Structure and Host Adaptation of Salmonella Typhimurium from Wild Birds | Journal of Clinical Microbiology (asm.org) Detailed β-(1→3)-D-glucan and mannan antigen kinetics in patients with candidemia | Journal of Clinical Microbiology (asm.org) Interlaboratory comparison of Pseudomonas aeruginosa phage susceptibility testing | Journal of Clinical Microbiology (asm.org) Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm(55) | Journal of Clinical Microbiology Commentary: Plasmid-mediated drug resistance in mycobacteria: the tip of the iceberg? | Journal of Clinical Microbiology Guests: Melissa Miller, Ph.D., D(ABMM), FAAM, University of North Carolina Medical Center Patricia Simner, Ph.D., D(ABMM), Johns Hopkins University School of Medicine This episode of Editors in Conversation is brought to you by the Journal of Clinical Microbiology and hosted by JCM Editor in Chief, Alex McAdam and Dr. Elli Theel. JCM is available at https://jcm.asm.org and on https://twitter.com/JClinMicro. Visit journals.asm.org/journal/jcm to read articles and/or submit a manuscript.
In this two-part mini-series we are focusing on health systems strengthening- what it is, how to do it and what action is needed to ensure that the approach is embedded in discussions at key global events and discussion platforms. This episode follows on from the first episode from the Centre for Health Systems Strengthening at the Liverpool School of Tropical Medicine (episode 60) which focused on the health diplomacy and how researchers can advocate for health systems strengthening approaches and community voices in health diplomacy spaces. Today we hear from two advocates who have been acting within health diplomacy spaces and as researchers. We hear from Emmanuel Zaizay, who is affected by the Neglected Tropical Disease Buruli Ulcer, about his experience of growing skills and capacity to communicate the needs of people affected by stigmatising neglected tropical diseases.We also hear from Maurine Murenga, a TB advocate who has represented the TB community in high level UN meetings. She is open and honest about both the strengths and opportunities of being an advocate, but also what this means to her on a personal level. Her open reflections are really critical to how researchers function when engaging with communities.Episode guests:Dr Kerry Millington - Research Uptake Manager, Liverpool of Tropical MedicineKerry has been working in global health for over 20 years with a keen focus on ending the tuberculosis epidemic. A key part of her work is developing trusted relationships with range of stakeholders to work in partnership, in collaboration and in a coordinated way ensuring the academic and health professional voice credibly informs decisions that impact on health. This can range from co-creating research ideas to influencing policy and political commitments. A key stakeholder to engage with is the voice of TB survivors and advocates to accelerate action for those in most need of innovations in TB care and prevention to transform lives. Maurine Murenga - Coordinator of TB Women GlobalMaurine Murenga is a passionate advocate for the health, development and human rights of women and children. Maurine's passion for advocacy is driven by her lived experience, and the inequality and vulnerability that young women and adolescent girls experience in her community.Maurine is currently the coordinator of TB Women Global, Board Member of Unitaid, Friend of the Fight US and EGPAF Kenya. She is a former board member of the Global Fund to fight AIDS, TB and Malaria and is also a member of WHO's Global Accelerator for Pediatric Formulations Advisory and Union Working Group Gender Equity in TB. In Kenya – Maurine is a member of the Global Fund Country Coordinating Mechanism and Elimination of Mother to Child Transmission of HIV Committee of Experts.Emmanuel Zaizay – Co-researcher and advocate, REDRESS, Liverpool School of Tropical Medicine Emmanuel Zaizay is from Lofa County, Voinjama District. He works with REDRESS as a coresearcher and was recruited as a patient affected person having been diagnosed with Buruli ulcer. He also serves as a data collector, working in photovoice settings and participatory methods such as bodymapping and focus group discussions. Useful links:S8E3 - Being a co-researcher with lived experience of an NTD - Emmanuel Zaizay, who is a peer researcher in the REDRESS programme and is affected by Buruli Ulcer, a neglected tropical disease, features in this earlier epsiode. He shares with us the value of learning new skills, through becoming a co-researcher, which has helped him better connect with his community and contribute to the improvement of...
In this weeks episode Amanda and CJ talk a flesh eating bacteria, ants and playing Age of Empires and it finally happens again - the last story we both picked the same one, we talk about how helicopters make crocodiles randy Next episode will be released: 30/10/2023 Get in touch: Email us - fmedeadpodcast@gmail.com Follow us - Twitter (twitter.com/fmedeadpodcast) or Instagram (instagram.com/fmedeadpodcast/) at @fmedeadpodcast Support the show by donating on Ko-Fi - ko-fi.com/fmedeadpodcast Website - fuckmedeadpodcast.com We'd be forever grateful if you took the time to rate and leave a review in your preferred podcast app! Support the show (https://ko-fi.com/fmedeadpodcast) Credits: https://www.dailymail.co.uk/news/article-12613491/Buruli-ulcer-Flesh-eating-virus.html https://www.abc.net.au/news/rural/2023-10-03/age-of-empires-computer-game-ant-warfare-simulation-csiro-uwa/102923706 https://www.iflscience.com/crocodile-sex-bonanza-triggered-by-low-flying-chinook-in-australia-70971
Maladie chronique causée par une bactérie qui se développe dans la peau, l'ulcère de Buruli a été signalé dans 33 pays d'Afrique, des Amériques, d'Asie et du Pacifique occidental. La bactérie cause des dommages cutanés et, en l'absence de traitement précoce, peut entrainer des handicaps à long terme. Comment expliquer, le plus simplement possible, les signes évocateurs de l'ulcère de Buruli ? Cette maladie tropicale bactérienne rare et ancienne reste-t-elle complexe à traiter ? Doit-on forcément opérer ? Dr Patrick Knipper, chirurgien spécialiste en chirurgie plastique et en chirurgie de la main à l'Hôpital Européen Georges Pompidou de Paris et Président d'Interplast-France / Chirurgie Sans Frontières, ONG de chirurgie réparatrice dans les pays en voie de développement► Retrouvez l'émission en entier ici
Maladie chronique causée par une bactérie qui se développe dans la peau, l'ulcère de Buruli a été signalé dans 33 pays d'Afrique, des Amériques, d'Asie et du Pacifique occidental. La bactérie cause des dommages cutanés et, en l'absence de traitement précoce, peut entrainer des handicaps à long terme. Quels sont les modes de transmission ? Comment reconnaitre les symptômes ? Quels sont les traitements existants ? Dr Patrick Knipper, chirurgien spécialiste en chirurgie plastique et en chirurgie de la main à l'Hôpital Européen Georges Pompidou de Paris et Président d'Interplast-France / Chirurgie Sans Frontières, ONG de chirurgie réparatrice dans les pays en voie de développement Dr Jean Gabin Houezo, coordinateur du programme de lutte contre la lèpre et l'ulcère de Buruli du Bénin► En fin d'émission, nous parlons d'une étude qui vient d'être publiée dans la revue Nature Communications mettant en évidence une nouvelle molécule au potentiel thérapeutique dans le traitement du paludisme. Les explications d'Anne Houdusse, directrice de Recherche CNRS et directrice de l'équipe motilité Structurale à l'Institut Curie.Programmation musicale :► Laetitia Zonzambé – Mbi Nze► Emma Lamadji & Fidel Fourneyron – Ho o lo
Maladie chronique causée par une bactérie qui se développe dans la peau, l'ulcère de Buruli a été signalé dans 33 pays d'Afrique, des Amériques, d'Asie et du Pacifique occidental. La bactérie cause des dommages cutanés et, en l'absence de traitement précoce, peut entrainer des handicaps à long terme. Quels sont les modes de transmission ? Comment reconnaitre les symptômes ? Quels sont les traitements existants ? Dr Patrick Knipper, chirurgien spécialiste en chirurgie plastique et en chirurgie de la main à l'Hôpital Européen Georges Pompidou de Paris et Président d'Interplast-France / Chirurgie Sans Frontières, ONG de chirurgie réparatrice dans les pays en voie de développement Dr Jean Gabin Houezo, coordinateur du programme de lutte contre la lèpre et l'ulcère de Buruli du Bénin► En fin d'émission, nous parlons d'une étude qui vient d'être publiée dans la revue Nature Communications mettant en évidence une nouvelle molécule au potentiel thérapeutique dans le traitement du paludisme. Les explications d'Anne Houdusse, directrice de Recherche CNRS et directrice de l'équipe motilité Structurale à l'Institut Curie.Programmation musicale :► Laetitia Zonzambé – Mbi Nze► Emma Lamadji & Fidel Fourneyron – Ho o lo
Dr Lou Cooper, Counselling Psychologist and Director of Talking Emotions, discusses the benefits and practice of emotion-focused therapy; Dr Andrew Buultjens, Postdoctoral Research Scientist at The Peter Doherty Institute for Infection and Immunity, unpacks the causes, symptoms, and treatment of buruli ulcers; and the team canvass text-based healthcare consults. With presenters Dr Nick, Prudence Dear, and Dr Sonia.Website: https://www.rrr.org.au/explore/programs/radiotherapyFacebook: https://www.facebook.com/RadiotherapyOnTripleR/Twitter: https://twitter.com/_radiotherapy_Instagram: https://instagram.com/radiotherapy_tripler
In this week's episode we hear from Emmanuel Zazay who is a peer researcher in the REDRESS programme and is affected by Buruli Ulcer, a neglected tropical disease. He shares with us the value of learning new skills, through becoming a co-researcher, which has helped him better connect with his community and contribute to the improvement of medical and psychosocial services for people living with NTDs. Emmanuel Zazay Co-researcher, REDRESS I am Emmanuel Zazay from Lofa County, Voinjama District. I work with REDRESS as a coresearcher and I was recruited as a patient affected person as I was diagnosed with Buruli ulcer. I also serve as a data collector, I work in photovoice settings and participatory methods such as bodymapping and focus group discussions. Currently, I am with the coresearcher team in Lofa County. https://www.redressliberia.org/ (https://www.redressliberia.org/) Twitter: @REDRESS_Liberia Fasseneh Zeela Zaizay REDRESS Country Director, Actions Transforming Lives/REDRESS Mr Fasseneh Zeela Zaizay serves as the Liberian Country Program Manager for REDRESS, providing overall management for the project in Liberia. Zeela holds B.Sc. in Nursing (Magna Cum Laude), master's in public health, Diploma of Advanced Studies in Health Care Management, and certificate in monitoring and evaluation. Zeela co-designed Cuttington University's clinical outreach program and served as its coordinator as well as lectured nursing for 7 years. Before joining REDRESS, he served as the Liberian Country Director of MAP International and Technical Assistant to the Ministry of Health. In those roles, he engaged in strengthening the Liberian health system, supporting the integration of NTDs into the health system, and conducting research on health system strengthening and NTDs. He is a co-creator of the Liberian Strategic Plan for the Integrated Management of NTDS. He is a co-founder of Actions Transforming Lives, a registered Liberian charity and partner on REDRESS also providing financial and technical support to the Ministry of Health NTDs Program, as well as giving less fortunate communities access to safe water and improved livelihoods. https://www.redressliberia.org/about-us/people/actions-transforming-lives/fasseneh-zeela-zaizay/ (https://www.redressliberia.org/about-us/people/actions-transforming-lives/fasseneh-zeela-zaizay/) Twitter: @REDRESS_Liberia Twitter: @FZZaizay
After 25 years of painstaking research, could scientists be getting close to unlocking the mysteries of Buruli ulcer?
When people from a small beach town on Phillip Island started developing severe skin lesions, scientists were left scratching their heads as to what was causing them.
Ulcère de Buruli, maladie de Chagas, leishmaniose ou encore filariose lymphatique... L'OMS recense 20 maladies tropicales négligées qui touchent plus d'un milliard de personnes. Ces maladies sévissent dans les zones où l'accès à des services de santé de qualité, à l'eau potable et aux moyens d'assainissement est difficile. Quelles sont les caractéristiques de ces maladies ? Comment les prévenir ? Est-il possible de les éradiquer ? Pr Arezki Izri, maître de conférences universitaires, chef du service de Parasitologie à l'Hôpital Avicenne de Bobigny, en région parisienne. Pr Henri Assé, chirurgien plasticien engagé depuis 20 ans sur le terrain dans la lutte contre la lèpre et l'ulcère de Buruli en Côte d'Ivoire. Consultant pour les maladies tropicales négligées auprès de l'OMS. Ancien directeur coordonnateur du Programme national de lutte contre l'Ulcère de Buruli en Côte d'Ivoire.
Activist Simon Mulvany of Save the Bees Australia discusses a new way of tackling mosquitos which spread bacteria causing buruli ulcers. Instead of gassing large areas with harmful insecticides, traps are used to attract mosquitos. This environmentally-friendly approach to a serious health problem has recently attracted government funding.
Episode 1419: Our article of the day is Buruli ulcer.
Ο γενικός ιατρός Γιώργος Αμπουγιάννης συνομιλεί με τον Αλέξανδρο Λογοθέτη, με αφορμή το συναγερμό που έχει σημάνει στις υγειονομικές υπηρεσίες της πολιτείας.
Tom Elliott spoke with Professor Tim Stinear, Molecular Microbiologist from the Doherty Institute, who explained more about the Buruli ulcer. See omnystudio.com/listener for privacy information.
Konrad Marshall's July 2019 cover story, 'Jeepers Creepers', studies the flesh-eating bacteria known as Buruli ulcer, which is causing horrific wounds to local communities along Victoria's coastal towns. Konrad is then joined in conversation by Professor Tim Stinear, one of the world's foremost expert on the ulcer from the Doherty Institute, and Good Weekend associate editor Greg Callaghan, to discuss the origins of Mycobacterium ulcerans and how this "zoonosis" - an infection in animals that spreads to humans - is thought to come from the humble ringtail possum. Discussion starts at: 27:00. Become a subscriber: our supporters power our newsrooms and are critical for the sustainability of news coverage. Becoming a subscriber also gets you exclusive behind-the-scenes content and invitations to special events. Click on the links to subscribe https://subscribe.theage.com.au/ or https://subscribe.smh.com.au/ Please take the time to rate & review us on Apple Podcasts or wherever you get your pods. We love to hear your thoughts and it makes it easier for the rest of the podcast world to find us. See omnystudio.com/listener for privacy information.
L’ulcère de Buruli est une infection chronique qui affecte la peau, parfois les os, et qui peut entraîner des déformations permanentes. Le mode de transmission de cette maladie est encore inconnu : il est donc difficile de la prévenir. La maladie du sommeil, ou trypanosomiase africaine est lié à un parasite, transmis par les mouches tsé-tsé, dans une vingtaine de pays d’Afrique subsaharienne. Elle affecte les animaux comme les humains et en l’absence de traitement, elle peut être mortelle. Le nombre de cas est en forte baisse depuis 10 ans, mais la vigilance s’impose pour confirmer ces progrès. Que sait-on de ces deux maladies tropicales négligées ? Où en est la recherche sur le sujet ? Comment faire le bon diagnostic ? Quels traitements existent ou sont en cours de développement ? Dr Jean Jannin, président de la Société Francophone de Médecine Tropicale et Santé Internationale, ex-Société de Pathologie exotiqueDr Dramane Kaba, médecin entomologiste, chercheur, maître de Recherche à l'Institut National de Santé Publique. Directeur de l'Institut Pierre Richet (IPR) à Bouaké en Côte d’ivoire (Centre de recherche de l'Institut National de Santé Publique). Et également membre du Comité de direction du LAMIVECT Laboratoire Mixte International sur les Maladies à Vecteurs.Dr Vincent Jammoneau, chercheur en parasitologie à l'Institut de Recherche pour le Développement (IRD), mène des recherches sur la maladie du sommeil, depuis plus de 20 ans, principalement en Afrique de l'Ouest, et, coordonne depuis 2016 un projet d'élimination en Côte d'IvoirePr Jacques Chandenier, professeur émérite de Parasitologie, Mycologie, et Médecine tropicale de la Faculté de Médecine de Tours. Secrétaire général de la Société francophone de médecine tropicale. Trésorier de laSociété française de mycologie médicale. Pour aller plus loin : Film de sensibilisation réalisé en 2017 en Côte d'Ivoire : "La maladie du bout de la piste".
Dr. Horn reviews several important tropical diseases, including Chagas disease (caused by Trypanosoma cruzii), spread by the Triatomid bug, African Trypanosomiasis, the cause of sleeping sickness, Cystercercosis, caused by the Pork tapeworm, and Buruli ulcer. He closes by discussing Onchocerciasis and its effect on significant areas of the developing world.
Four important biotech stories from the past two years: Interview with leading scientists on the leprosy-like Buruli ulcer outbreak in southeastern Australia; Taming drug-resistant superbugs; Deadly fungus Candida Auris spreading around the world; Effective vaccination against influenza.
So far health experts have figured out that possums feces contain the flesh-eating bug (Mycobacterium ulcerans-Buruli ulcer) and mosquito might spread this disease to human. But how can we prevent it or treat it? - Txheeb tau tias muaj cov kab mob bacteria noj tib neeg tej nqaij ntawm xeev Victoria thiab teb chaws Australia no thiab tej tej kws kho mob tseem tsis tau paub tias yuav tiv thaiv tau li cas.
Das Buruli Ulkus, eine durch Mycobacterium ulcerans verursachte Hautinfektion, betrifft vor allem Kinder und Jugendliche
Piers talks with leading experts on Buruli ulcers Professor Tim Stinear of the Doherty Institute and Professor Paul Johnson, Director of Research at Austin Health. While they acknowledge gaps in their understanding, they explain the spread of the disease from Victoria's Bellarine Peninsula to the Mornington Peninsula and why they believe mosquitos are the likely link from possums which carry the bacteria to humans. More: https://www2.health.vic.gov.au/public-health/infectious-diseases/beating-buruli
A dangerous and hard-to-treat ulcer is spreading among residents and visitors on the Mornington Peninsula. The Victorian Government and health authorities are scrambling to understand the enigmatic bacteria which causes infection. To restrict a possible disease vector, an extensive 'fogging' campaign may be used to target mosquitos from October. But activist Simon Mulvany of Save The Bees Australia has grave concerns about the effects of pesticides on bees and other insects. His petition on change.org garnered well over 8000 signatures in 3 days.
This week Claire updates us on the flesh-eating Buruli ulcer epidemic and research into how it's spread; Stu tells us all about rare earth metals that are used in modern technology and how they're not so rare any more; and Chris looks at the PFAS chemicals behind the water contamination in Bundaberg and other places in Australia (for updates see www.bundaberg.qld.gov.au/pfas).
A flesh eating ulcer, known as Buruli has led to a record number of amputations in Melbourne this year. The number of cases has tripled in the last five years, with the disease spreading from Victoria’s coastal towns to inner city Melbourne – and researchers have no idea why. Drive Tuesday chatted to Associate Professor […]
This week, marine scientist Sophie Burgess tells us everything we want to know about scallops and how to predict their population, and microbiologist Tim Stinear explains why we shouldn't panic about Mycobacterium ulcerans, aka the flesh-eating bacteria that's causing Buruli ulcers on Victoria's Mornington Peninsula, but how you can protect yourself nevertheless.DHHS website:https://www2.health.vic.gov.au/about/news-and-events/healthalerts/bairnsdale-buruli-ulcerhttps://www2.health.vic.gov.au/public-health/infectious-diseases/disease-information-advice/mycobacterium-ulceranshttps://www.betterhealth.vic.gov.au/health/healthyliving/Buruli-ulcer
When he was in high school, Emmanuel Agumah was diagnosed with Buruli ulcer. Categorized as a neglected tropical disease, or “NTD,” it kept him hospitalized for approximately three years and bedridden for about a year and a half. The disease, which he could have chosen to view as a disability, has instead given him a cause for which he fights. Agumah founded the Buruli Ulcer Victims Aid (BUVA) Foundation, which focuses on socio-economic support for former Buruli ulcer patients and those with disabilities. Read more: https://goo.gl/xu88yf
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 16/19
Thu, 30 Jan 2014 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/16645/ https://edoc.ub.uni-muenchen.de/16645/1/Huber_Kristina.pdf Huber, Kristina Lydia Balbina ddc:610, ddc:600, Medizinische Fakultät
Background: In a previous study PCR analysis of clinical samples from suspected cases of Buruli ulcer disease (BUD) from Togo and external quality assurance (EQA) for local microscopy were conducted at an external reference laboratory in Germany. The relatively poor performance of local microscopy as well as effort and time associated with shipment of PCR samples necessitated the implementation of stringent EQA measures and availability of local laboratory capacity. This study describes the approach to implementation of a national BUD reference laboratory in Togo. Methodology: Large scale outreach activities accompanied by regular training programs for health care professionals were conducted in the regions ``Maritime'' and ``Central,'' standard operating procedures defined all processes in participating laboratories (regional, national and external reference laboratories) as well as the interaction between laboratories and partners in the field. Microscopy was conducted at regional level and slides were subjected to EQA at national and external reference laboratories. For PCR analysis, sample pairs were collected and subjected to a dry-reagent-based IS2404-PCR (DRB-PCR) at national level and standard IS2404 PCR followed by IS2404 qPCR analysis of negative samples at the external reference laboratory. Principal Findings: The inter-laboratory concordance rates for microscopy ranged from 89% to 94%; overall, microscopy confirmed 50% of all suspected BUD cases. The inter-laboratory concordance rate for PCR was 96% with an overall PCR case confirmation rate of 78%. Compared to a previous study, the rate of BUD patients with non-ulcerative lesions increased from 37% to 50%, the mean duration of disease before clinical diagnosis decreased significantly from 182.6 to 82.1 days among patients with ulcerative lesions, and the percentage of category III lesions decreased from 30.3% to 19.2%. Conclusions: High inter-laboratory concordance rates as well as case confirmation rates of 50% (microscopy), 71% (PCR at national level), and 78% (including qPCR confirmation at external reference laboratory) suggest high standards of BUD diagnostics. The increase of non-ulcerative lesions, as well as the decrease in diagnostic delay and category III lesions, prove the effect of comprehensive EQA and training measures involving also procedures outside the laboratory.
Sun, 1 Jan 2012 12:00:00 +0100 http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001747 https://epub.ub.uni-muenchen.de/15747/1/oa_15756.pdf Bretzel, Gisela; Loescher, Thomas; Kere, Abiba Banla; Badziklou, Kossi; Diefenhardt, Adolf; Hoffmann, Harald; Wiedemann, Franz; Kobara, Basil; Amekuse, Komi; Nitschke, Joerg; Jansson, Moritz; Symank, Dominik; Maman, Issaka; Piten, Ebekalisai; Beissner, Marcus
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 13/19
Thu, 7 Jul 2011 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/13322/ https://edoc.ub.uni-muenchen.de/13322/1/Beissner_Marcus_W.pdf Beissner, Marcus Wilfried
Background: Since the early 1990s more than 1,800 patients with lesions suspicious for Buruli ulcer disease (BUD) have been reported from Togo. However, less than five percent of these were laboratory confirmed. Since 2007, the Togolese National Buruli Ulcer Control Program has been supported by the German Leprosy and Tuberculosis Relief Association (DAHW). Collaboration with the Department for Infectious Diseases and Tropical Medicine (DITM), University Hospital, Munich, Germany, allowed IS2404 PCR analysis of diagnostic samples from patients with suspected BUD during a study period of three years. Methodology/Principal Findings: The DAHW integrated active BUD case finding in the existing network of TB/Leprosy Controllers and organized regular training and outreach activities to identify BUD cases at community level. Clinically suspected cases were referred to health facilities for diagnosis and treatment. Microscopy was carried out locally, external quality assurance (EQA) at DITM. Diagnostic samples from 202 patients with suspected BUD were shipped to DITM, 109 BUD patients (54%) were confirmed by PCR, 43 (29.9%) by microscopy. All patients originated from Maritime Region. EQA for microscopy resulted in 62% concordant results. Conclusions/Significance: This study presents a retrospective analysis of the first cohort of clinically suspected BUD cases from Togo subjected to systematic laboratory analysis over a period of three years and confirms the prevalence of BUD in Maritime Region. Intensified training in the field of case finding and sample collection increased the PCR case confirmation rate from initially less than 50% to 70%. With a PCR case confirmation rate of 54% for the entire study period the WHO standards (case confirmation rate >= 50%) have been met. EQA for microscopy suggests the need for intensified supervision and training. In January 2011 the National Hygiene Institute, Lome, has assumed the role of a National Reference Laboratory for PCR confirmation and microscopy.
Thu, 1 Jan 2009 12:00:00 +0100 https://epub.ub.uni-muenchen.de/11304/1/Bretzel_Gisela.pdf Bretzel, Gisela