POPULARITY
6 episodes with ntds
3 episodes with ntds
2 episodes with ntds
3 episodes with ntds
2 episodes with ntds
2 episodes with ntds
2 episodes with ntds
2 episodes with ntds
2 episodes with ntds
In this opening episode of the mini-series, we explore how moments of crisis—from economic collapse to political instability—create fertile ground for anti-feminist backlash. We hear how patriarchal power is mobilised across contexts and how resisting it requires collective action that cuts across sectors, including health. Co-host Ishrat Jahan is joined by Lebanese researcher and activist Nay El Rahi and Kenyan programme officer Alfred Makabira, who share personal reflections and strategies for countering gender backlash in their own work.In this episode:Ishrat Jahan - Research Fellow at the Centre for Gender and Sexual and Reproductive Health at BRAC James P. Grant School of Public Health in Dhaka, Bangladesh. Ishrat's research focuses on the intersection of gender, health, and environmental issues. Ishrat is involved in national and international projects exploring the impact of climate change on women's health, adaptive practices in marginalised communities, and Global South-led curricula in higher education.Nay El Rahi – Researcher, Lebanese American University, Arab Institute for Women (AiW) Nay is an intersectional feminist writer, researcher, and political activist with over a decade of experience in journalism, research, and programming. Based at the Arab Institute for Women at the Lebanese American University, Nay's work focuses on anti-feminist backlash, gender-based violence, and kinship in Lebanon. She co-founded HarassTracker, a pioneering tool for reporting sexual harassment in Lebanon, and was named one of the BBC's 100 Women in 2016.Alfred Makabira - Programme Officer, Advocates for Social Change-Kenya (ADSOCK). Alfred is a human rights advocate working as part of the Countering Backlash: Reclaiming Justice project, developing and implementing practical strategies to help individuals and communities identify, resist, and challenge patriarchal backlash both online and in their local contexts.Useful links:CREA - Feminist Human Rights - Our Voices Our FuturesCountering Backlash - Reclaiming Gender JusticeWant to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast cuts across disciplines, including health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare (antenatal and postnatal care), mental health and wellbeing, vector-borne diseases, climate change and co-production approaches. If you would like your project or programme to feature in an episode or miniseries, get in touch with the producers of Connecting Citizens to Science, the SCL Agency.
Ripoti ya Shirika la Umoja wa Mataifa la Afya Duniani (WHO) ya takwimu za afya duniani iliyochapishwa jana Mei 15 ikionesha athari kubwa zaidi za kiafya zilizosababishwa na janga la COVID-19 kuhusu vifo, muda wa kuishi na hali ya afya na ustawi kwa ujumla, imeweka wazi kuwa katika kipindi cha miaka miwili pekee, kati ya mwaka 2019 na 2021, matarajio ya kuishi yalipungua kwa mwaka mmoja na miezi nane ikiwa ni maporomoko makubwa zaidi katika historia ya hivi karibuni hali iliyobatilisha mafanikio ya afya yaliyopatikana kwa muongo mmoja.
Who doesn't love a new tool? In this episode of Security Noise, Geoff and Skyler talk to Senior Research Analyst Alex Ball about his new open-source tool DIT Explorer. DIT Explorer opens a .dit file of your choosing (NTDS.dit is the file housing the data for Windows Active Directory), loads the directory schema, and presents the objects as a tree. Alex takes us through the tool's functions, why and how he created it, and upcoming updates. Learn more about DIT Explorer in Alex's blog: https://trustedsec.com/blog/exploring-ntds-dit-part-1-cracking-the-surface-with-dit-explorer About this podcast: Security Noise, a TrustedSec Podcast hosted by Geoff Walton and Producer/Contributor Skyler Tuter, features our cybersecurity experts in conversation about the infosec topics that interest them the most. Hack the planet! Find more cybersecurity resources on our website at https://trustedsec.com/resources.
In this final episode of our mini-series on research capacity strengthening, we explore how pursuing a PhD, using the PACTS programme (Patient-centred Sickle Cell Disease Management in sub-Saharan Africa), as a real-world example—can enhance, rather than compete with, clinical practice.Our guests reflect on what it means to balance research with clinical care, teaching, community outreach, and academic responsibilities, and share honest insights about the challenges and opportunities that come with embedding a PhD within a larger programme. From learning by doing to mentoring the next generation, this episode looks at how research can be a powerful tool for real-world impact in health systems.In this episode:Dr. Mmamulatelo Siame Mumba - PhD Student, SBA lead, Project coordinator, ZambiaDr. Mmamulatelo Siame Mumba is a paediatrician and implementation researcher based in Zambia. She is undertaking a PhD with the Liverpool School of Tropical Medicine and leads the Standards-Based Audit teams across PACTS sites while coordinating research activities on the ground.Dr. Hezekiah Isa Albarka - Lecturer at University of Abuja, NigeriaDr. Hezekiah Isa Albarka is a senior lecturer at the University of Abuja and a haematologist with a long-standing interest in sickle cell disease. He is currently pursuing a PhD through the PACTS project, building on years of experience in clinical care and academic teaching.Dr. Eunice Agyeman Ahmed - PhD Student Liverpool School of Tropical Medicine, Ghana Dr. Eunice Agyeman Ahmed is a haematologist at Komfo Anokye Teaching Hospital in Ghana and a PhD student at the Liverpool School of Tropical Medicine. Her research supports adolescents with sickle cell disease transitioning into adult care, alongside her wider advocacy and training work across Ghana and Africa. Patient-Centered Sickle Cell Disease Management in Sub-Saharan AfricaPatient-centred sickle cell disease management in sub-Saharan Africa (PACTS) | LSTMWant to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast cuts across disciplines, including health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare (antenatal and postnatal care), mental health and wellbeing, vector-borne diseases, climate change and co-production approaches. If you would like your project or programme to feature in an episode or miniseries, get in touch with the producers of Connecting Citizens to Science, the SCL Agency.
In ep 119 of “How Do You Say That?!” sponsored by britishvoiceover.co.uk, Elroy "Spoonface" Powell joins Sam and Mark to talk about jumping from character to character in an instant, we find out exactly what "Muffin Pants" really are in what Sam thinks might be the most fun script we've ever had, and Spoon brings a Barry White depth that we had to explore!Our VO question this week is all about mindfulness... Spoon's an expert in this field and gives some tremendous tips on how you can look after yourself and protect your mental health in what can be a pretty tough industry!Get involved! Have you got a Wildcard suggestion that we should try or an idea for the show? Send it to us via Mark or Sam's social media or email it directly to podcast@britishvoiceover.co.ukScript 1True Sight helps to treat and prevent five debilitating diseases that affect more than a billion people globally.These are known as neglected tropical diseases (NTDs) and two of them are a major cause of preventable blindness around the world, particularly in low- and middle-income countries.True Sight works with thousands of local volunteers and has distributed more than a billion donated treatments to protect people against NTDs. They have helped to eliminate trachoma in several countries, including The Gambia, Ghana, Malawi, Benin, Mali and most recently Pakistan.Script 2(overexcited announcer)"Tired of choosing between breakfast... and pants?!"(fashion model voice)"Introducing... Muffin Pants. They bake while you strut."(scientist voice, slightly unhinged)"With patented CrumbTech™ insulation, each cheek stays toasty!"(grandma voice)"Back in my day, we just sat on a pie and hoped for the best."(military drill sergeant)"You want carbs? You want comfort? DROP AND GIVE ME FLAVOUR!"(cheery jingle-style sing-song)"Muffin Paaaants — hot buns, on the run!"We'd love your feedback - and if you listen on Apple Podcasts or Spotify, hit the follow button today!**Listen to all of our podcasts here - you can also watch on YouTube, or say to your smart speaker "Play How Do You Say That?!"About our guest: Elroy ‘Spoonface' Powell, aka ‘Spoon The Voice Guy,' is an award-winning voice actor known for his commanding performances in gaming, film, and TV. His role as Jack Matt in Dying Light 2 won him the One Voice Award for Best Male Voice in Gaming. He has also voiced Minecraft Legends, Harold Halibut, and appeared in Star Wars: Episode VII and Fighting With My Family.With a background in music, Spoon blends vocal mastery with storytelling. His work in mindfulness and EFT enhances his ability to deliver authentic, emotionally rich performances. He has also collaborated with UNESCO, amplifying indigenous voices. Elroy Spoonface's Website @spoonface1 on Instagram Elroy Spoonface on YouTubeYou can also read more about Mindfulness with Spoon's...
In this second episode of our mini-series on Research Capacity Strengthening (RCS), we explore what it means to widen the focus of capacity strengthening, beyond researchers and clinicians, to include media, programme managers, community leaders, teachers, caregivers, and more.Hosted on location at the PACTS Year 3 Partners Meeting, this episode shows how the PACTS programme (Patient-centred Sickle Cell Disease Management in sub-Saharan Africa) has embedded a more inclusive and cyclical approach to RCS. You'll hear how strengthening media capacity, using content analysis, and co-developing strategies with non-clinical stakeholders can make health systems more responsive and sustainable. We also look at how information itself, when shared in the right way with patients and communities, can be a powerful form of capacity strengthening.In this episode:Dr. Motto Nganda – Global Health Researcher: Collaborative Implementation Research for Health Systems Strengthening, Liverpool School of Tropical MedicineMotto is a medical and public health professional from the University of Douala and the Liverpool School of Tropical Medicine. He brings over six years' experience in participatory implementation research, focusing on person-centred care and health system strengthening in the Global South. In PACTS, Motto supports implementation research across all three countries, coordinating participatory action cycles, standards-based audits, and realist evaluation.Bernard Appiah - Assistant Professor, Department of Public Health, Falk College, Syracuse UniversityBernard is a pharmacist, journalist, and Assistant Professor at the Department of Public Health, Syracuse University, USA. He is also Director of the Centre for Science and Health Communication in Ghana. With expertise in media, health communication, and public engagement, Bernard leads the media content analysis and communication work for PACTS. His work connects journalists and researchers, builds capacity through joint training, and strengthens how sickle cell disease is communicated across public platforms and policy.Reuben Chianumba - Programme Manager for the PACTS Project, Centre of Excellence for Sickle Cell Research and Training (CESRTA), University of AbujaReuben is the Programme Manager for PACTS in Nigeria, with a background in Medical Biochemistry and extensive experience in research coordination, stakeholder engagement, and community mobilisation. He supports the delivery of PACTS objectives at CESRTA and plays a key role in integrating newborn screening, capacity-building workshops, and local advocacy efforts.Useful Links:Patient-Centered Sickle Cell Disease Management in Sub-Saharan AfricaPatient-centred sickle cell disease management in sub-Saharan Africa (PACTS) | LSTMWant to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast cuts across disciplines, including health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare (antenatal and postnatal care), mental health and wellbeing, vector-borne diseases, climate change and co-production approaches. If you would like your project or programme to feature in an episode or miniseries, get in touch with the producers of Connecting Citizens to Science, the SCL Agency.
Welcome to our new mini-series on research capacity strengthening, produced in partnership with the Centre for Capacity Research at the Liverpool School of Tropical Medicine. In this first episode, we explore the design of a Research Capacity Strengthening (RCS) component within an implementation research project, and why it is crucial for sustainable, patient-centred healthcare. Our conversation draws insights from those actively embedding RCS into their work, demonstrating how improving research skills and systems drives real impact in global health.In this episode:Dr. Justin Pulford - Reader at the Centre for Capacity Research, Liverpool School of Tropical Medicine.Dr. Justin Pulford is Deputy Head of the Centre for Capacity Research (CCR) at the Liverpool School of Tropical Medicine (LSTM). A behavioural scientist by training, he has extensive experience developing, implementing, and evaluating research and health systems strengthening initiatives across sub-Saharan Africa and the South Pacific. Dr Pulford also convenes the ‘TROP 703: Public Health Programmes, Policies and Strategies' module for LSTM's MPH programme. Professor Obiageli Nnodu - Co-lead of the PACTS programme, University of Abuja.Professor Obiageli Nnodu is Professor of Haematology and Blood Transfusion at the University of Abuja, Nigeria, and Director of its Centre of Excellence for Sickle Cell Disease Research and Training. She leads multiple NIH-funded sickle cell projects and chairs Africa's largest SCD network. Professor Nnodu also advises the Nigerian government on non-communicable diseases and serves on WHO AFRO committees dedicated to improving sickle cell care.Professor Alex Osei-Akoto - Kwame Nkrumah University of Science and Technology, GhanaProfessor Alex Osei-Akoto is Principal Investigator for PACTS in Ghana. A Professor of Child Health at Kwame Nkrumah University of Science and Technology (KNUST) and Consultant Paediatrician at Komfo Anokye Teaching Hospital, he has focused on sickle cell disease for over two decades. Professor Osei-Akoto led key newborn screening initiatives, advised Ghana's Ministry of Health on SCD, and co-authored numerous publications. He now spearheads PACTS implementation in Ghana, building on his extensive clinical and research leadership in paediatric haematology.Dr. Catherine Chunda-Liyoka - University of ZambiaDr. Catherine Chunda-Liyoka is Head of the Paediatric Haematology Department at Zambia's University Teaching Hospitals–Children's Hospital. She provides specialised care in sickle cell disease, haemophilia, aplastic anaemia, HIV, and TB, while leading multiple research initiatives. As an Honorary Lecturer at the University of Zambia and an Honorary Fellow at LSTM, she mentors health workers nationwide. Dr. Chunda-Liyoka also advises the Zambian Ministry of Health on paediatric haematology and infectious diseases, and plays a key role in major SCD networks—including SPARCO and PACTS—to strengthen national guidelines and clinical practices.Useful linksCentre for Capacity Research | LSTMPatient-centred sickle cell disease management in sub-Saharan Africa (PACTS) | LSTMWant to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast cuts across disciplines, including health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare (antenatal and postnatal care), mental...
Global health systems have long been shaped by Western frameworks that separate health from land, environment, and community. But for Indigenous communities worldwide, health is holistic—deeply rooted in ancestral knowledge, cultural traditions, and reciprocal relationships with nature.Yet, Indigenous ways of knowing have been overlooked and undervalued within research, policymaking, and health interventions. How can we shift this paradigm and centre Indigenous-led approaches in global health?In this episode, we speak with Dr. Walter Flores, Dr. Rebecca Rae, and Dr. Lorenda Belone about Indigenous communities in health research, examining systemic barriers, the importance of Indigenous knowledge in health equity, navigating differences between Indigenous and Western research approaches, and how policy shifts impact Indigenous communities. We also discuss the connection between research, activism, and advocacy.Our guests:Dr. Walter Flores - Research Professor, Accountability Research Center, American University, Washington DC, USADr. Walter Flores is a social scientist and human rights advocate with over 25 years of professional experience. He holds a PhD and a Masters of Community Health from the Liverpool School of Tropical Medicine, UK. Dr Flores' professional work has been carried out in more than 30 countries from Latin America, Africa, Asia and Europe. His areas of expertise are health systems and policy, right to health and indigenous populations, democratic governance, social accountability, legal empowerment and community participation. Currently, Dr Flores is research professor at the Accountability Research Center, American University, Washington DC and a research associate at the Center for the Study of Equity and Governance in Health Systems.Dr. Lorenda Belone – Professor, University of New Mexico College of Population Health / Center for Participatory ResearchDr. Belone (Diné/Navajo) is from Naakaii Bito' located on the Navajo Nation and has been engaged in community-based participatory research (CBPR) with an Indigenous paradigm focused on health disparities with southwest tribal nations. Her research includes partnerships with Tribal Research Teams (Apache, Navajo & Pueblo) on an Indigenous family prevention program called the Family Listening Program (FLP). As an Indigenous CBPR researcher, Dr. Belone integrates her own cultural and tribal knowledge to overcome historical negative research experiences and tribal community members' perceptions of research exploitation.Rebecca Rae, MCRP, MWR - Research Lecturer III, University of New Mexico College of Population HealthRebecca Rae (Jicarilla Apache), MCRP, MWR, is a Research Lecturer III at the University of New Mexico's College of Population Health. She is an Indigenous scholar, with eighteen years of implementing community-based participatory research (CBPR) projects and Indigenous participatory evaluation in partnership with Tribal communities. She works closely with multiple tribal community partners to mentor, strengthen, and enhance community members' skills in program development, implementation, data collection, data analysis, grant writing, research, and evaluation. Useful links: Want to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast cuts across disciplines, including health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare (antenatal and postnatal care), mental health and wellbeing, vector-borne diseases, climate change and co-production approaches. If you would like your project or programme to feature in an episode or...
"FAN MAIL - How does this episode resonate with you?"This two-part episode shines a light on the lived experiences of two remarkable individuals affected by NTDs. We explore firsthand how disability influences and affects their lives. In part 2, host Garry Aslanyan speaks with Dan Izzett, a former civil engineering technician and pastor who has turned his retirement into a powerful mission advocating for people living with leprosy. Peter Waddup, the CEO of the Leprosy Mission in Great Britain, provides a thoughtful reflection on Dan's message and its practical implications for the global health community. Related episode documents, transcripts and other information can be found on our website. Subscribe to the Global Health Matters podcast newsletter. Follow @TDRnews on Twitter, TDR on LinkedIn and @ghm_podcast on Instagram for updates. Disclaimer: The views, information, or opinions expressed during the Global Health Matters podcast series are solely those of the individuals involved and do not necessarily represent those of TDR or the World Health Organization. All content © 2024 Global Health Matters. Pre-roll content;We're in the full swing of our season four. If you just found us, we have close to 40 episodes for you to explore. You don't need to listen to them in sequence. You can look them up and choose a la carte topics and issues that most interest you. I promise you will want to hear them all.
Global health systems are built on power structures that often exclude the very voices that should be leading the conversation. Funding, publishing, and policymaking have long been dominated by high-income countries, creating systemic barriers to equity.In this episode, Dr. Shashika Bandara (McGill School of Population and Global Health), Dr. Moses Tetui (Umeå University & University of Waterloo), and Dr. Joseph Mumba Zulu (University of Zambia) discuss two major initiatives that challenge these structures:The Lancet article: Shifting Power in Global Health Will Require Leadership by the Global South and Allyship by the Global North and The launch of the Journal of Community Systems for Health, a new platform breaking barriers in global publishing and knowledge sharing.In this episode:Dr. Shashika Bandara - Post-Doctoral Fellow, Department of Global and Public Health, School of Population and Global Health, McGill University.Shashika Bandara is a Sri Lankan post-doctoral fellow at the Department of Global Public Health in the School of Population and Global Health at McGill University. He co-leads McGill University's research examining policy exemplars successfully addressing structural discrimination with O'Neill-Lancet Commission on Racism, Structural Discrimination and Global Health. Dr. Joseph Mumba Zulu - Associate Professor of Community, School of Public Health, University of Zambia Joseph M Zulu is a co-founder and Editorial Board Member of the Journal of Community Systems for Health, a platform dedicated to promoting inclusive, socially accountable, and community-driven health systems research. He is an Associate Professor of Community Health at the School of Public Health and has been involved in community-based implementation research projects in different countries across Africa.Dr. Moses Tetui - Assistant professor, University of Waterloo, Canada and Umeå University, SwedenDr. Moses Tetui is a Health Systems Researcher who specialises in using participatory methods to collaborate with diverse communities and stakeholders to address health system challenges. He serves as a founding board member of the Journal of Community Systems for Health. Moses collaborates with researchers, communities, and decision-makers to explore climate change adaptation strategies for communities living in informal settlements across Africa. Useful links:How to prevent equity efforts from losing steam in global health academiaImagining a future in global health without visa and passport inequitiesShifting power in global health will require leadership by the Global South and allyship by the Global NorthThe Journal of Community Systems for Health (JCSH)Want to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast cuts across disciplines, including health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare (antenatal and postnatal care), mental health and wellbeing, vector-borne diseases, climate change and co-production approaches. If you would like your project or programme to feature in an episode or miniseries, get in touch with the producers of Connecting Citizens to Science,
"FAN MAIL - How does this episode resonate with you?"This two-part episode shines a light on the lived experiences of two remarkable individuals affected by NTDs. We explore firsthand how disability influences and affects their lives. In part 1, host Garry Aslanyan speaks with Mulikat Okanlawon, a survivor of noma in Nigeria and President of the Elysium Noma Survivors Association. Thanks to the tireless advocacy of Mulikat and other survivors, noma was officially recognized as an NTD by the World Health Organization in 2023. Claire Jeantet, an award-winning documentary filmmaker, speaks about collaborating with Mulikat over the past eight years to bring her story and the stories of other noma survivors to policymakers, academics and the public.Related episode documents, transcripts and other information can be found on our website. Subscribe to the Global Health Matters podcast newsletter. Follow @TDRnews on Twitter, TDR on LinkedIn and @ghm_podcast on Instagram for updates. Disclaimer: The views, information, or opinions expressed during the Global Health Matters podcast series are solely those of the individuals involved and do not necessarily represent those of TDR or the World Health Organization. All content © 2024 Global Health Matters. Pre-roll content;We're in the full swing of our season four. If you just found us, we have close to 40 episodes for you to explore. You don't need to listen to them in sequence. You can look them up and choose a la carte topics and issues that most interest you. I promise you will want to hear them all.
In this episode, Trista explores the complexities of managing pregnancy with PCOS, focusing on dietary considerations, the safety of medications and supplements, and the importance of mental health during the postpartum period. She emphasizes the need for careful monitoring of blood sugar levels, the role of insulin and metformin, and the significance of support systems for new parents. You'll learn: Why managing glycemic load is crucial for pregnant individuals with PCOS Safe and effective treatments for gestational diabetes How postpartum mental health is a significant concern for new parents Navigating potential chest feeding challenges for those with PCOS Episode Links: How to Manage Gestational Diabetes with Diet and Lifestyle 1-on-1 Nutrition Coaching References: Choudhury, A. A., & Rajeswari, V. D. (2022). Polycystic ovary syndrome (PCOS) increases the risk of subsequent gestational diabetes mellitus (GDM): A novel therapeutic perspective. Life Sciences (1973), 310, 121069–121069. https://doi.org/10.1016/j.lfs.2022.121069 Diabetes Canada. (2024). Gestational diabetes. https://www.diabetes.ca/about-diabetes/gestational Facchinetti, F., Cavalli, P., Copp, A. J., D'Anna, R., Kandaraki, E., Greene, N. D. E., & Unfer, V. (2020). An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs). Expert Opinion on Drug Metabolism & Toxicology, 16(12), 1187–1198. https://doi.org/10.1080/17425255.2020.1828344 Ibrahim, I., Bashir, M., Singh, P., Al Khodor, S., & Abdullahi, H. (2022). The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control. Frontiers in Nutrition (Lausanne), 9, 867099–867099. https://doi.org/10.3389/fnut.2022.867099 Jorquera, G., Echiburú, B., Crisosto, N., Sotomayor-Zárate, R., Maliqueo, M., & Cruz, G. (2020). Metformin during Pregnancy: Effects on Offspring Development and Metabolic Function. Frontiers in Pharmacology, 11, 653–653. https://doi.org/10.3389/fphar.2020.00653 Koric, A., Singh, B., VanDerslice, J. A., Stanford, J. B., Rogers, C. R., Egan, D. T., Agyemang, D. O., & Schliep, K. (2021). Polycystic ovary syndrome and postpartum depression symptoms: a population-based cohort study. American Journal of Obstetrics and Gynecology, 224(6), 591.e1-591.e12. https://doi.org/10.1016/j.ajog.2020.12.1215 Ryssdal, M., Vanky, E., Stokkeland, L. M. T., Jarmund, A. H., Steinkjer, B., Løvvik, T. S., Madssen, T. S., Iversen, A.-C., & Giskeødegård, G. F. (2023). Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS. The Journal of Clinical Endocrinology and Metabolism, 108(9), e743–e753. https://doi.org/10.1210/clinem/dgad145 Slouha, E., Alvarez, V. C., Gates, K. M., Ankrah, N. M. N., Clunes, L. A., & Kollias, T. F. (2023). Gestational Diabetes Mellitus in the Setting of Polycystic Ovarian Syndrome: A Systematic Review. Curēus (Palo Alto, CA), 15(12), e50725–e50725. https://doi.org/10.7759/cureus.50725 Vanky, E., Isaksen, H., Haase Moen, M., & Carlsen, S. M. (2008). Breastfeeding in polycystic ovary syndrome. Acta Obstetricia et Gynecologica Scandinavica, 87(5), 531–535. https://doi.org/10.1080/00016340802007676
Our final episode from the Health Systems Research Symposium in Nagasaki showcases transformative ideas in global health systems research and policy. This episode features discussions on interdisciplinary capacity building, decolonising health policy research, One Health approaches, and advancing gender equity in health systems.Dr. Hanna-Tina Fischer explores innovative capacity-building models and interdisciplinary research frameworks. Dr. Ayat Abu-Agla discusses the importance of decolonisation in health policy and systems research. Dr. Rosie Steege highlights the interconnectedness of humans, animals, and ecosystems through One Health and its implications for antimicrobial resistance. Finally, Dr. Zahra Zeinali reflects on her work advancing gender mainstreaming and intersectionality in health systems research.This episode offers fresh perspectives for researchers, practitioners, and policymakers dedicated to creating equitable and resilient health systems.In this episode:From ReBUILD for Resilience: Abriti Arjyal -Research Manager, HERD InternationalThazin La - Research manager for the health systems research programme, Burnet Institute MyanmarOur Guests:Hanna-Tina Fischer – Postdoctoral Research Scientist, Charité Universitätsmedizin BerlinDr. Ayat Abu-Agla - Health Services Management Centre Lead, University of Birmingham, Dubai Dr. Rosie Steege – Lecturer, Liverpool School of Tropical MedicineZahra Zeinali – Doctoral Candidate, Department of Global Health, University of Washington. Useful links:One healthHSR Global Symposium on Health Systems Research | HSR 2024Introducing ReBUILD for Resilience - health systems researchRebuild ConsortiumWant to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast covers topics like health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare, mental health, vector-borne diseases, climate change, and co-production approaches.If you would like your project or programme to feature in an episode or mini-series, get in touch with the producers of Connecting Citizens to Science, the SCL Agency.
Recorded live at the Eighth Global Symposium on Health Systems Research, the episode focuses on the challenges and opportunities of delivering health care in fragile and conflict-affected settings. Collaborating with researchers from the ReBUILD for Resilience consortium, we hear from three inspiring voices tackling displacement, migration, and exclusion in health care.Dr. Cynthia Maung shares insights on creating governance structures for health care delivery to displaced populations along the Thai-Myanmar border. Dr. Roshan Pokhrel from Nepal reflects on using research to address workforce challenges amid migration and climate change. Finally, Lydia DiStefano highlights the critical role of community health workers in providing equitable care to vulnerable populations and shares exciting plans for the upcoming Community Health Workers Symposium in Bangkok.This episode offers vital lessons for policymakers, practitioners, and researchers committed to building resilient health systems in fragile settings.In this episode:From ReBUILD for Resilience: Karen Miller – Communications Officer, Liverpool School Tropical Medicine Shophika Regmi - Senior Manager: Health System Research, Evaluation and Learning, HERD International, NepalThazin La - Research manager for the health systems research programme, Burnet Institute MyanmarOur Guests:Dr. Cynthia Maung – Mae Tae ClinicDr. Roshan Pokhrel – Secretary Ministry of Health Population, Nepal Lydia DiStefano – Senior Research and Advocacy Manager, Community Partners International Useful links:The 4th International CHW SymposiumHSR Global Symposium on Health Systems Research | HSR 2024Introducing ReBUILD for ResilienceWant to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast covers topics like health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare, mental health, vector-borne diseases, climate change, and co-production approaches.If you would like your project or programme to feature in an episode or mini-series, get in touch with the producers of Connecting Citizens to Science, the SCL Agency.
In this special episode, recorded live at the 8th Global Symposium on Health Systems Research (HSR2024) in Nagasaki, we explore key themes shaping the global health landscape. This episode brings together voices from the halls of HSR2024, where our host and researchers from the ReBUILD for Resilience programme have been capturing insightful conversations with experts on resilience, climate, and just health systems.Hosted by Dr. Kim Ozano, this episode includes interviews with inspiring speakers tackling complex global health challenges, from conflict-affected settings to ethical health financing.Join us as we share dynamic discussions and explore what they mean for the future of health systems.In this episodeFrom ReBUILD for Resilience: Rouham Yamout – Programme Coordinator, American University of BeruitKaren Miller – Communications Officer, Liverpool School Tropical Medicine Our Guests:Ana Amaya – Board Member, Health Systems GlobalDr. Ali Ardalan - Regional Advisor and Head of Health Systems Resilience Unit, WHO Eastern Mediterranean Region.Dr. Usman Gwarzo – LAFIYA programme, Nigeria Useful links:8th Global Symposium on Health Systems Research (HSR2024)Introducing ReBUILD for Resilience - health systems researchRebuild ConsortiumWant to hear more podcasts like this?Follow Connecting Citizens to Science on your usual podcast platform or YouTube to hear more about current research and debates within global health.The podcast covers topics like health systems strengthening, gender and intersectionality, tropical diseases (NTDs, TB, Malaria), maternal and child healthcare, mental health, vector-borne diseases, climate change, and co-production approaches.If you would like your project or programme to feature in an episode or mini-series, get in touch with the producers of Connecting Citizens to Science, the SCL Agency.
"FAN MAIL - How does this episode resonate with you?"Significant progress has been made towards a malaria-free world. Forty-three countries have successfully eliminated malaria, with Cabo Verde becoming the third African country declared malaria-free earlier this year. Africa, however, still continues to experience the highest share of the global malaria burden, with 94% of malaria cases and malaria deaths. To discuss the challenges and opportunities to eliminate malaria, host Garry Aslanyan speaks with two influential African women leaders. Francine Ntoumi is the Founder, President and Executive Director of the Congolese Foundation for Medical Research in the Republic of the Congo who served as the first African leader of the Multilateral Initiative on Malaria. Corine Karema is the Director of Malaria, NTDs and Global Health at Quality & Equity HealthCare in Rwanda. Corine is also the former Director of the Rwanda National Malaria Control Programme and served as Interim CEO of the Roll Back Malaria Partnership.Related episode documents, transcripts and other information can be found on our website.Subscribe to the Global Health Matters podcast newsletter. Follow @TDRnews on Twitter, TDR on LinkedIn and @ghm_podcast on Instagram for updates. Disclaimer: The views, information, or opinions expressed during the Global Health Matters podcast series are solely those of the individuals involved and do not necessarily represent those of TDR or the World Health Organization. All content © 2024 Global Health Matters.
Ungana na Leah Mushi anayekutea jarida la Umoja wa Mataifa hii leo likiangazia juhudi za Afrika katika kujenga miji endelevu, mapambano ya kutokomeza magonjwa ya kitropiki yasiyopewa kipaumbele, matumizi ya sayansi katika nyanja mbalimbali za maisha na mashinani utasikia juhudi za kuhakikisha mipaka ya nchi inaendelea kuwa wazi hata wakati wa majanga ya asili na migogoro.
Huko Zanzibar Tanzania, shirika la Umoja wa Mataifa la Afya Duniani, WHO kanda ya AFrika, linashirikiana na serikali kukabili ugonjwa wa matende ambao ni miongoni mwa magonjwa ya kitropiki yaliyopuuzwa au NTDs. Bosco Cosmas na maelezo zaidi.(Taarifa ya Bosco Cosmas)Video ya WHO kanda ya Afrika inatupeleka Zanzibar, Tanzania nyumbani kwa Hamis Njani akitembea kwa shida, miguu imevimba. Alipata ugonjwa wa matende akiwa na umri wa miaka 18 lakini sasa WHO imempatia matumaini.(Sauti ya Hamis Njani)“Inaweza kukupata homa siku mbili kwa wiki, kwa hiyo nikashindwa kwenda shuleni. Wakati mwingine nashindwa kuhudhuria shule kwa miezi hata mitatu. Ninapokwenda kule hospitali, ninapata huduma na mafunzo ya jinsi ya kuishi na haya maradhi kama vile kusafisha, kutumia dawa na mengine yote.”Ugonjwa huu huenezwa na mbu. Husababisha miguu au korodani kujaa maji .Tangu mwaka 2010 Zanzibar imeendesha kampeni 20 za mgao wa dawa na WHO imetoa dawa kutibu watu milioni 1.5 kila mwaka. Asha Makame ni Mgawaji wa dawa kwenye jamii.(Sauti ya Asha Makame)“Mwanzo ulikuwa mgumu kwa sababu watu walikuwa hawaelewi. Kwa sasa hivi mwitikio ni mzuri kwa sababu kile kitu watu wamekitumia na wanajua faida yake.WHO imefundisha pia madaktari katika kila hospitali ya wilaya kufanya upasuaji wa kisasa wa mabusha kwa wagonjwa 500. Dkt. Shali Ahmed ni Meneja Mradi wa NTDs, Wizara ya Afya, Zanzibar.(Sauti ya Dkt. Shali Ahmed - Meneja wa mradi)“Ninaamini kufikia mwaka 2030, hata kabla ya hapo tutakuwa tumekomesha ugonjwa wa matende. Kwa hiyo tunawashukuru sana WHO kwa ushirikiano tunaoupata kwa kupata dawa, mara nyingi tunapata dawa kwa wakati na za kutosha kwa ajili ya nchi nzima.”
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: How Platinum Helps Draw Attention to Japan's Role in Global Health Funding, published by Open Philanthropy on August 27, 2024 on The Effective Altruism Forum. Japan spent more than $19.6 billion on overseas development assistance (ODA) in 2023, making it the third largest single-country donor behind the US and Germany. Open Philanthropy's Global Aid Policy (GAP) team, which is devoted to increasing government aid and guiding it toward more cost-effective approaches, believes there may be opportunities to increase the impact of this aid through targeted advocacy efforts. They estimate that in Western nations like the UK, for every $1,000 spent on ODA, aid advocacy funders spend around $2.60 attempting to support and inform its allocation. Meanwhile, in Japan, advocacy spending is a mere $0.25 for the same amount - more than 10 times less. Accordingly, the GAP program has prioritized work in Japan. The following case study highlights one grantee helping to drive this work forward. ***** One day in March 2023, in the district of Wayanad near India's southern tip, hundreds of villagers lined up for an uncommon service from an unexpected source: a check-up on their lung health, courtesy of Fujifilm. The Japanese company, best known for its cameras, was taking a different kind of picture. Its portable, 3.5 kg battery-powered X-ray machine, designed to deliver hospital-grade diagnostics, enables tuberculosis screenings in regions where medical facilities usually lack the necessary technology. This scene was just one stop on an illuminating trip to India for a group of Japanese journalists and youth activists. From Toyota Tsusho's Sakra World Hospital to Eisai's efforts to combat neglected tropical diseases (NTDs) in Yarada village, each site visit highlighted Japanese businesses and researchers contributing to global health initiatives. Recognizing this opportunity, Open Philanthropy supported Platinum, a Tokyo-based PR firm, in organizing a trip across India aimed at boosting the Japanese public's awareness of urgent global health issues, particularly tuberculosis and neglected tropical diseases (NTDs). Sixteen people attended: six journalists, representing outlets ranging from a long-running daily newspaper to a popular economics broadcast, and 10 youth activists sourced from PoliPoli's Reach Out Project, an Open Philanthropy-funded initiative that incubates charities focused on global health advocacy. Our Senior Program Officer for Global Aid Policy, Norma Altshuler, thought the initiative was timely given recent trends in Japan's ODA spending. Between 2019 and 2022, the share of Japanese ODA allocated to global health doubled (or tripled, including COVID-19 relief). To sustain this momentum, Open Philanthropy is supporting Japanese groups that aim to preserve or grow Japan's commitment to prioritizing global health initiatives. In a post-trip interview with Open Philanthropy, Soichi Murayama, who helped organize the trip, says one challenge of Japan's media landscape "is that Japanese media doesn't cover global health very often." Murayama attributes the dearth of dedicated coverage to limited reader interest, creating a feedback loop where minimal reporting leads to low awareness, which in turn reduces appetite for such stories. Ryota Todoroki, a medical student who participated in the trip, echoes this sentiment: "NTDs are often seen as a foreign issue with no relevance to Japan, so changing this perception is a major challenge." The Fujifilm initiative in Wayanad provides an example of how connecting Japanese companies to global health efforts can help illustrate the impact of foreign aid. This approach not only highlights Japan's technological contributions but also links economic interests with humanitarian efforts. To gauge the impact of awareness campaigns, PR pr...
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There are a group of parasites extremely disgusting and mean. Humanity declared war on them. Follow the show to join us in this audio experience of Kurzgesagt - In a Nutshell. A fan-made show out of admiration for the works of Kurzgesagt - In a Nutshell. Learn more about your ad choices. Visit megaphone.fm/adchoices
With the frequency and severity of pandemics likely becoming more severe in the future and communicable diseases like HIV, Malaria, Tuberculosis, and NTDs being out of sight and out of mind despite killing millions each year, this warrants a closer look.In this episode, we'll explore future pandemic threats and communicable diseases as monumental challenges, their impact on global citizens, contributing factors, concerns for the future, and how they are shaping our world.References In Our Discussion◼️ New study suggests risk of extreme pandemics like COVID-19 could increase threefold in coming decades ◼️ What are the top 10 public health challenges in 2023? ◼️ 11 global health issues to watch in 2023, according to IHME experts Podcast Hosts & Producers◼️ Gordon Thane, BMSc, MPH, PMP®◼️ Leshawn Benedict, MPH, MSc, PMP®Podcast Production Notes◼️ 1st audio clip at the beginning adapted from ‘The next outbreak? We're not ready | Bill Gates | TED' ◼️ 2nd audio clip adapted from ‘Taking on the Big Three: Can Africa Eliminate AIDS, TB, and Malaria?'◼️ Background music for the intro: Mandelbro - Thinking and FeelingSubscribe to the NewsletterSubscribe to the newsletter so you don't miss out on the latest podcast episodes, live events, job skills, learning opportunities, and other engaging professional development content here.Leave Us A Five Star RatingIf you enjoy our podcasts, be sure to subscribe and leave us a rating on Apple Podcast or Spotify, and spread the word to your friends to help us get discovered by more people.
Monday morning episode to cover breaking global and public health news for the week of December 11, 2023. Stories: Anthrax outbreak in Zambia Mystery illness in dogs is spreading in the US Food recalls + hospitalization and death stats COVID-19 & Flu cases increase while RSV may have peaked $777 million dollars donated to combat NTDs in Africa and Yemen Citations: https://www.cdc.gov/outbreaks/index.html https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON497 https://www.who.int/news/item/04-12-2023-global-partners-pledge-usd777-million-to-combat-neglected-tropical-diseases https://www.webmd.com/covid/news/20231204/covid-flu-rates-rising-rsv-may-have-peaked https://www.webmd.com/cold-and-flu/news/20231128/cdc-says-flu-cases-rising-12000-hospitalized https://www.webmd.com/food-recipes/food-poisoning/news/20231127/cantaloupes-recalled-salmonella-linked-3-deaths
Hoje, vamos falar de um assunto actual e perigoso: o Rhysida Ransomware. Já ouviu falar dele? Se não, esteja atento, porque esta ameaça está a crescer. Vamos perceber o que é o Rhysida, como funciona e o que pode fazer para se proteger. Por isso, esteja alerta!Rhysida Baseado no MITRE ATT&CK:****1. Acesso Inicial**: - **T1078**: Aquisição de contas RDP/VPN comprometidas. - **T1566**: Técnicas de phishing usando e-mails maliciosos.**2. Execução**: - **T1059**: Uso do PowerShell para execução de comandos, alterações no registro e implantação de malware.**3. Persistência**: - **T1053**: Estabelecimento de tarefas agendadas para persistência.**4. Evasão de Defesa**: - **T1070.004**: Deleção de arquivos do ransomware e seus artefatos. - **T1112**: Modificações no Registro do Windows.**5. Acesso a Credenciais**: - **T1003.003**: Cópia do arquivo NTDS.dit via `ntdsutil.exe`.**6. Movimento Lateral**: - **T1021.001**: Uso do RDP e serviços remotos para movimentação.**7. Comando e Controle**: - **T1021.001**: Serviços remotos como RDP, WinRm, e PsExec para comando e controle.**8. Exfiltração**: - **T1041**: Transmissão de dados para servidor C2.**9. Impacto**: - **T1486**: Criptografia dos arquivos da vítima usando RSA e ChaCha20.
In this episode we will be hearing about a seven year research programme known as COUNTDOWN. COUNTDOWN consisted of multidisciplinary research teams across 4 countries- Ghana, Liberia, Nigeria and Cameroon and used co-production research approaches to improve the equity and efficiency of health systems interventions to control and eliminate seven Neglected Tropical Diseases. Research was implemented at each of the health system levels from policy to community and is all documented in the Journal ‘International Health' as a supplement entitled Stronger together: evidence for collaborative action on neglected tropical diseases. The supplement tells the story of how the programme engaged with people who have lived experience, health workers, and policy makers and really emphasises the importance of togetherness. Our guests today are Dr Luret Lar who was the programme manager employed by Sightsavers Nigeria, a collaborator on the COUNTDOWN programme, Dr Karsor Kollie who is the Program Director for Neglected Tropical Diseases at the Ministry of Health Liberia and Laura Dean from the Liverpool School of Tropical Medicine who was the Social Science lead for COUNTDOWN. Dr Laura Dean – Lecturer, Liverpool School of Tropical MedicineLaura has worked for the last 15 years in the use of participatory health research methodologies to support community and health systems development across sub-Saharan Africa and south Asia. Through participatory action research projects, she supports capacity strengthening within communities and health systems so that stakeholders can identify challenges and co-produce solutions. The majority of her work has focused on increasing inclusion and participation of people with lived experience of mental health conditions and chronic infectious diseases of poverty, for example neglected tropical diseases.Dr. Luret Lar - Medical Doctor, Public Health Physician, Lecturer, University of Jos, NigeriaLuret was involved in implementation research for seven years in collaboration with Liverpool School of Tropical Medicine when she was working for Sightsavers. Her interest and passion about preventive medicine and including the voices of the voiceless have influenced her research career over the years. Luret was interested in inclusivity at all levels of implementation in the neglected tropical diseases programme. This connected her with people affected by neglected tropical diseases and implementers at the community facility, state, and federal levels. She worked closely with these implementers to co-produce solutions to implementation challenges that everyone collectively identified.Karsor Kollie – Programme Director, Ministry of Health, LiberiaSince 2011, Mr Kollie has established and headed the Liberian Integrated NTDs Prevention and Control Programme and is based within the Ministry of Health and Social Welfare. He developed the NTD country master plan which forms the operational national guide for the next 5 years.Under his leadership the Liberian programme is making excellent progress in MDA control of Lymphatic Filariasis, Onchocerciasis, Schistosomiasis, Soil-transmitted Helminthiasis (STH) where treatment coverage has not gone below 75%, respectively. Alongside this, he is making significant progress in the development and application of new monitoring and evaluation criteria tailoring activities effectively with difficult on-the-ground terrain.More information can be found in the special supplement discussed in this episode: Stronger together: evidence for collaborative action on neglected tropical diseases | International Health | Oxford Academic (oup.com)Want to hear more podcasts like...
This is a special episode dedicated to President Carter, who aged 98 has recently entered a hospice, and the extraordinary impact he has had around the world in the decades since leaving the White House.From resolving conflicts and building homes for the poor, to eradicating disease and championing human rights, President Carter's impact has been felt far and wide and in 2002, he was awarded the Nobel Peace Prize. We hear from people he worked with, as well as those whose lives he has touched, his grandson Jason Carter, who is now board chair of The Carter Center - a nonprofit he set up to focus on conflict resolution, democracy, and health - and Curtis Kohlhaas, the organisation's director of international philanthropy.Born in 1924 in Plains Georgia, James Earl Carter Jr. served in the US Navy before his opposition to racial segregation took him into politics. He was governor of Georgia from 1971 to 1975 and in 1976 became the 39th president of the United States.One of the last remaining members of his generation of leaders, President Carter displayed a unique ability to relate to ordinary people – something credited to his own humble upbringing as the son of a peanut farmer. Yet, he was also able to leverage his high-level connections to work on issues neglected by the majority and bring them into the mainstream. In addition to their work with The Carter Center, President Carter and his wife Rosalyn have also been long-time supporters of housing charity, Habitat for Humanity. And, until very recently, despite both being quite frail, spent several days a year volunteering and over the years personally helped to build and renovate thousands of homes.One of President Carter's least well-known areas of work, yet possibly his most impactful, relates to Guinea worm, a waterborne parasite, which causes untold suffering its hosts.In the 1980s, when the Carter Center began its programme to tackle the disease, there were believed to be more than 3.5million cases worldwide. As of last year, the global caseload stood at just 13 - in five countries (Angola, Chad, Ethiopia, Mali and South Sudan) – which is equivalent to a 99.99 percent decrease and Guinea worm is now on course to become only the second human disease - after smallpox - to be eradicated.The Just 13 poem about Guinea worm featured in the podcast was written and performed by Waleed Gubara. The Impact Room is brought to you by Philanthropy Age and Maysa Jalbout. This episode was produced and edited by Louise Redvers. Find us on social media @PhilanthropyAge
This week, Dr. Jen tackles two pressing questions that have been buzzing around. First, she dives into the MTHFR variant and its impact on folate processing, demystifying this complex topic in a way that's easier to understand. But that's not all. She also addresses a timely concern about the current state of abortion bans. Specifically, she provides guidance for expectant mothers in the face of complications during pregnancy and limited abortion access in the U.S. Moreover, Dr. Jen sheds light on the significance of folic acid during pregnancy and shares her expert recommendations for couples trying to conceive. Dr. Jen's mission with this discussion is to empower listeners with knowledge, debunk myths, and equip them with the confidence to advocate for more comprehensive reproductive healthcare. Tune in for an informative and eye-opening episode! What's going down: Understanding the MTHFR enzyme and its role in folate processing The difference between folate and folic acid Neural tube defects and why taking folic acid is necessary Why abortion bans negatively impact intentionally pregnant people too Unpacking the 12-week ban in North Carolina and the BS that comes along with it Clitorally appalled by the state representative's ability to "jump ship". See the video here. Dr. Jen's advice for anyone trying to get pregnant in a state where abortion is banned Thank you for continuing the conversation and calling into the Viva la Vulva Voicemail at (503) 893-2016! Please be sure to rate, follow, review, and remember that nothing is considered TMI around here. Social & Website TikTok: @drjenniferlincoln Instagram: @drjenniferlincoln YouTube: @drjenniferlincoln Website: www.drjenniferlincoln.com Resources Grab a copy of my book HERE! Obstetricians For Reproductive Justice References https://www.cdc.gov/ncbddd/folicacid/mthfr-gene-and-folic-acid.html https://www.cdc.gov/ncbddd/folicacid/faqs/faqs-general-info.html#:~:text=The%20terms%20%E2%80%9Cfolic%20acid%E2%80%9D%20and,(5%2DMTHF)%201. https://www.marchofdimes.org/find-support/topics/planning-baby/neural-tube-defects#:~:text=NTDs%20happen%20in%20about%203%2C000,year%20in%20the%20United%20States. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381685/ https://www.acog.org/womens-health/faqs/good-health-before-pregnancy-prepregnancy-care#:~:text=At%20least%201%20month%20before,of%20folic%20acid%20each%20day. https://canons.sog.unc.edu/2023/05/north-carolinas-pending-abortion-legislation/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.11.536245v1?rss=1 Authors: Takla, T. N., Luo, J., Sudyk, R., Huang, J., Walker, J. C., Vora, N. L., Sexton, J. Z., Parent, J. M., Tidball, A. M. Abstract: Neural tube defects (NTDs) including anencephaly and spina bifida are common major malformations of fetal development resulting from incomplete closure of the neural tube. These conditions lead to either universal death (anencephaly) or life-long severe complications (spina bifida). Despite hundreds of genetic mouse models having neural tube defect phenotypes, the genetics of human NTDs are poorly understood. Furthermore, pharmaceuticals such as antiseizure medications have been found clinically to increase the risk of NTDs when administered during pregnancy. Therefore, a model that recapitulates human neurodevelopment would be of immense benefit to understand the genetics underlying NTDs and identify teratogenic mechanisms. Using our self-organizing single rosette spheroid (SOSRS) brain organoid system, we have developed a high-throughput image analysis pipeline for evaluating SOSRS structure for NTD-like phenotypes. Similar to small molecule inhibition of apical constriction, the antiseizure medication valproic acid (VPA), a known cause of NTDs, increases the apical lumen size and apical cell surface area in a dose-responsive manner. This expansion was mimicked by GSK3-{beta} and HDAC inhibitors; however, RNA sequencing suggests VPA does not inhibit GSK3-{beta} at these concentrations. Knockout of SHROOM3, a well-known NTD-related gene, also caused expansion of the lumen as well as reduced f-actin polarization. The increased lumen sizes were caused by reduced cell apical constriction suggesting that impingement of this process is a shared mechanism for VPA treatment and SHROOM3-KO, two well-known causes of NTDs. Our system allows the rapid identification of NTD-like phenotypes for both compounds and genetic variants and should prove useful for understanding specific NTD mechanisms and predicting drug teratogenicity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Nate is joined on this episode by Dr. Isaac Bogoch for a discussion on Neglected Tropical Diseases, global health equity, pandemic prevention and preparedness and his advocacy during the pandemic.He's a professor of medicine at U of T, an infectious diseases specialist with a focus on tropical diseases and HIV, and he became very public facing in his work and regular commentary through the COVID pandemic. Click here for more info on NTDs & click here to learn more about Nate's pandemic prevention & preparedness bill
Penyakit cacingan adalah salah satu dari Neglected Tropical Diseases (NTDs) atau Penyakit Tropis Terabaikan yang masih menjadi beban Indonesia. Bersama penyakit NTDs lainnya, cacingan disebabkan oleh berbagai patogen, termasuk virus, bakteri, protozoa, dan cacing parasit. Data Kementerian Kesehatan, tahun 2021 sebanyak 36,97 juta anak mendapatkan obat pencegahan massal (POPM) cacingan. Kemenkes juga melakukan survei pascapemberian obat cacing. Hasilnya ada 66 kabupaten kota yang memiliki prevalensi cacingan di bawah 5 persen, dan 26 daerah lainnya yang memiliki prevalensi cacingan di atas 10 persen. Di Ruang Publik KBR pagi kita bahas lebih jauh apa dampak cacingan dan bagaimana menghilangkan penyakit ini? Sudah bergabung bersama kita, dr. Ayodhia Pitaloka Pasaribu, Anggota Unit Kerja Koordinasi Infeksi Tropik Ikatan Dokter Anak Indonesia (IDAI).
Topics: Dangerous reporting: covering indigenous issues in Guatemala is difficult and comes with a high price -- Why care about neglected tropical diseases (NTDs)
Shirika la Umoja wa MAtaifa la afya ulimwenguni, WHO, limesema mataifa mengi zaidi duniani yametokomeza magonywa ya kitropiki yaliyosahaulika, au NTDs huku ikisema bado uwekezaji zaidi unahitajika kusongesha maendeleo hayo dhidi ya magonjwa hayo kama vile ukoma, vikope na kung'atwa na nyoka.Kauli hiyo ya WHO imetolewa leo ikiwa ni siku ya kimataifa ya kuhamasisha dhidi ya magonjwa hayo ya kitropiki yaliyosahaulika, NTDs na shirika limeweka hayo bayana kwenye ripoti mpya iitwayo Ripoti ya Dunia kuhusu NTDs kwa mwaka 2023. Ripoti imetaja mafanikio na changamoto ya kutibu NTDs duniani kote wakati huu ambapo matibabu yalivurugwa na mlipuko wa COVID-19. Mafanikio ni pamoja na idadi ya wagonjwa kupungua kwa milioni 80 kati ya mwaka 2020 na 2021 huku nchi 8 zikithibitishwa kutokomeza moja ya magonjwa hayo mwaka 2022 pekee na kufanya idadi ya nchi zisokuwa na NTDs duniani kote hadi mwezi Desemba mwaka jana kufikia 47.Hata hivyo ripoti inasisitiza uwekezaji zaidi kuchagiza kasi ya kutokomeza magonjwa hayo yanayoathiri maskini zaidi ili kufikia malengo ifikapo mwaka 2030.Mathalani uwekezaji unaopatia uwezo taifa kumiliki na kuwajibika na tiba na ufadhili wa uhakika.NTDs inaathiri zaidi jamii maskini hasa kwenye maeneo ambako huduma za maji safi na kujisafi ni haba, halikadhalika huduma za afya.Mkurugenzi Mkuu wa WHO Dkt. Tedros Ghebreyesus akizungumzia ripoti hiyo amesema duniani kote mamilioni ya watu wamekombolowe kutoka katika mzigo wa magonjwa hayo ambayo yanawatumbukiza kwenye mzunguko wa umaskini na unyanyapaa.Amesema “ingawa kuna hatua zaidi zinahitajika, lakini habari njema ni kwamba tuna mbinu na ufahamu wa sio tu kuokoa maisha na kuzuia machungu, bali pia kuokoa jamii nzima na mataifa yote dhidi ya ugonjwa huu. Wakati wa kuchukua hatua ni sasa, tuwekeze kwenye NTDs.”
Hii leo jaridani tuakuletea habari njema kuhusu afya na pia kuangazia jamii ya Benet nchini Uganda wakiwa bado hawana utaifa. Makala tunakwenda nchini Kenya na mashinani tunasalia huko huko Kenya, kulikoni?Shirika la Umoja wa Mataifa la afya ulimwenguni, WHO, limesema mataifa mengi zaidi duniani yametokomeza magonywa ya kitropiki yaliyosahaulika, au NTDs huku ikisema bado uwekezaji zaidi unahitajika kusongesha maendeleo hayo dhidi ya magonjwa hayo kama vile ukoma, vikope na kung'atwa na nyoka.Baada ya zaidi ya takriban miongo minane ya kutokuwa na utaifa, jamii ya watu wa asili ya Benet nchini Uganda inahaha kuishi, na kwa mujibu wa shirika la Umoja wa Mataifa la kuhudumia wakimbizi UNHCR bila kuwa na nyaraka rasmi muhimu jamii hiyo haiwezi kupata huduma za msingi kama elimu na afya , na sasa jamii hiyo inaiomba serikali ya Uganda kumaliza zahma hiyo iliyowaghubika kwa miongo.Makala tunakupeleka Kenya ambako huko mwandishi wetu Thelma Mwadzaya anamulika faida ya kuwa na kiwanda cha kutengeneza chakula lishe au tiba lishe kwa ajli ya watoto wenye utapiamlo uliokithiri.Katika mashinani tutasalia huko huko nchini Kenya kusikia ni jinsi gani wakimbizi wa Dadaab na wenyeji wameendelea kusihi pamoja kwa amani.Mwenyeji wako ni Assumpta Massoi, karibu!
You know those IDIOT REPUBLICANS who think that SCIENCE hasn't TOTALLY PROVEN that puberty blockers and hormones are AWESOME????? And TOTALLY REVERSIBLE????? Well two MOUTH-BREATHING IDIOTS who probably also HATE CRT and PUPPIES are so BIGOTED they don't even ACCEPT the MEDICAL CONSENSUS.(Show notes a bit longer and more in-depth than usual this week to help everyone follow along, double-check stuff, etc.)Show notes/Links:Carole hooven DESTROYS jon stewartThe state lawshttps://www.kff.org/other/issue-brief/youth-access-to-gender-affirming-care-the-federal-and-state-policy-landscape/Jesse on the state laws in 2020The vote went down after the episode was recorded, but Florida has now banned yuth gender medicine, with exceptions for those already receiving it and future research projectshttps://www.nytimes.com/2022/11/04/health/florida-gender-care-minors-medical-board.htmlThe full episode of Stewart's show: https://tv.apple.com/us/episode/the-war-over-gender/umc.cmc.1jj39s607lehulo4k0iscsarp“I don't send someone to a therapist when I'm going to start them on insulin.”https://www.theatlantic.com/magazine/archive/2018/07/when-a-child-says-shes-trans/561749/“Historically, mental health professionals have been charged with ensuring ‘readiness' [she puts that in scare quotes] for phenotypic transition, along with establishing a therapeutic relationship that will help young people navigate this very same transition. These 2 tasks are at odds with each other because establishing a therapeutic relationship entails honesty and a sense of safety that can be compromised if young people believe that what they need and deserve (potentially blockers, hormones, or surgery) can be denied them according to the information they provide to the therapist.” This excerpt strongly suggests she doesn't believe in the traditional gatekeeping role a mental-health clinician might play in a situation like this, helping to determine if a young person will benefit from transitioning.https://jamanetwork.com/journals/jamapediatrics/article-abstract/2504256Kids — sorry, sorry — “adolescents” — getting double mastectomies at 13 or 14https://pubmed.ncbi.nlm.nih.gov/29507933/“Suicide Attempts among Transgender and Gender Non-Conforming Adults: Findings of the Naitonal Transgender Discrimination Survey.”https://williamsinstitute.law.ucla.edu/wp-content/uploads/Trans-GNC-Suicide-Attempts-Jan-2014.pdfn.b.: “Without such probes, we were unable to determine the extent to which the 41 percent of NTDS participants who reported ever attempting suicide may overestimate the actual prevalence of attempts in the sample.” And:Finally, it should be emphasized that the NTDS, like all similar surveys, captured information about suicide attempts, not completed suicide. Lacking any information about completed suicide among transgender people (due primarily to decedents not being identified by gender identity or transgender status), it may be tempting to consider suicide attempt data to be the best available proxy measure of suicide death. Data from the U.S. population at large, however, show clear demographic differences between suicide attempters and those who die by suicide. While almost 80 percent of all suicide deaths occur among males, about 75 percent of suicide attempts are made by females. Adolescents, who overall have a relatively low suicide rate of about 7 per 100,000 people, account for a substantial proportion of suicide attempts, making perhaps 100 or more attempts for every suicide death. 13 suicides per 100,000 in a GIDS samplehttps://link.springer.com/article/10.1007/s10508-022-02287-7Insanely high rate of 2.8% in a Belgian clinical samplehttps://biblio.ugent.be/publication/8706800/file/8707586.pdfT H E G U I D E L I N E SStewart: So these, the guidelines that you wrote, because you were responsible with the endocrine board for writing guidelines of care for endocrinology.Safer: The Endocrine Society, yesStewart: The endocrine society.Yes.Stewart: And that was based on, uh, research papers, data, the things that you saw. Intervening with gender affirming care which may be just being respectful or, as they get older some of these other things. You've seen that have a reduction in depression, a reduction in suicide — that's what you've studied.Safer: Absolutely.Nothing about mental health improvement, lotta assessment-talk, “low evidence” at best https://academic.oup.com/jcem/article/102/11/3869/4157558?login=false#99603239The Ibuprofen System For Evidence Assessmenthttps://www.ncbi.nlm.nih.gov/books/NBK470778/table/app2.t2/Erica Anderson and Laura Edwards-Leeper take their concerns to the Washington Posthttps://www.washingtonpost.com/outlook/2021/11/24/trans-kids-therapy-psychologist/Jesse's interview with Anderson on BARPodRutledge: We don't have enough data, we don't have enough to show that these drugs are effective and that these children are better off. And that we should encourage…Stewart: You don't have enough, or it's not enough for you? I've got some bad news for ya. Parents with children who have gender dysphoria, have lost children, to suicide, and depression. Rutledge : They absolutely have.Stewart: —because it's acute. And so these mainstream medical organizations have developed guidelines through peer reviewed data, and studies. And through those guidelines, they've improved mental health outcomes.Rutledge's read on the evidence is perfectly reasonableHere's Sweden's National Board of Health and Welfare:For adolescents with gender incongruence, the [National Board of Health and Welfare] deems that the risks of puberty suppressing treatment with GnRH-analogues and gender-affirming hormonal treatment currently outweigh the possible benefits, and that the treatments should be offered only in exceptional cases. … To minimize the risk that a young person with gender incongruence later will regret a gender-affirming treatment, the NBHW deems that the criteria for offering GnRH-analogue and gender-affirming hormones should link more closely to those used in the Dutch protocol, where the duration of gender incongruence over time is emphasized.https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/kunskapsstod/2022-3-7799.pdfAnd here's Finlands' Council for Choices in Health Care, via an unofficial translationIn light of available evidence, gender reassignment of minors is an experimental practice. Based on studies examining gender identity in minors, hormonal interventions may be considered before reaching adulthood in those with firmly established transgender identities, but it must be done with a great deal of caution, and no irreversible treatment should be initiated. Information about the potential harms of hormone therapies is accumulating slowly and is not systematically reported. It is critical to obtain information on the benefits and risks of these treatments in rigorous research settings.https://segm.org/sites/default/files/Finnish_Guidelines_2020_Minors_Unofficial%20Translation.pdfNHS headed same wayhttps://www.engage.england.nhs.uk/specialised-commissioning/gender-dysphoria-services/user_uploads/b1937-ii-specialist-service-for-children-and-young-people-with-gender-dysphoria-1.pdfDutch stuffhttps://www.tandfonline.com/doi/full/10.1080/0092623X.2022.2121238https://www.tandfonline.com/doi/full/10.1080/0092623X.2022.2046221Depression and suicidality linked to blockers, perhaps rarelyhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019732s042,020517s038lbl.pdfThttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693622/“Testosterone Therapy is Associated With Depression, Suicidality, and Intentional Self-Harm: Analysis of a National Federated Database”https://www.sciencedirect.com/science/article/abs/pii/S1743609522012449#:~:text=Testosterone%20use%20was%20independently%20associated,testosterone%20deficient%20sub%2Dgroup%20analysisThe book to read on Thttps://www.amazon.com/Story-Testosterone-Hormone-Dominates-Divides/dp/1250236061The desistane literature is by no means “debunked,” and if you actually read the studies, no, the clinicians who wrote them did not confuse a bunch of merely gender nonconforming kids for genuinely gender dysphoric onesThese studies aren't perfect and come from different contexts, but they consistently tell the same storyhttp://www.sexologytoday.org/2016/01/do-trans-kids-stay-trans-when-they-grow_99.htmlThat story probably doesn't apply to kids who socially transition at a young age https://www.nytimes.com/2022/05/04/health/transgender-children-identity.htmlhttps://publications.aap.org/pediatrics/article/150/2/e2021056082/186992/Gender-Identity-5-Years-After-Social-Transition?autologincheck=redirected%3fnfToken%3d00000000-0000-0000-0000-000000000000Even at the bigger clinics that do take a multidisciplinary approach, and where kids could theoretically get comprehensive, holistic care, that isn't always happeninghttps://www.reuters.com/investigates/special-report/usa-transyouth-care/In interviews with Reuters, doctors and other staff at 18 gender clinics across the country described their processes for evaluating patients. None described anything like the months-long assessments de Vries and her colleagues adopted in their research. At most of the clinics, a team of professionals – typically a social worker, a psychologist and a doctor specializing in adolescent medicine or endocrinology – initially meets with the parents and child for two hours or more to get to know the family, their medical history and their goals for treatment. They also discuss the benefits and risks of treatment options. Seven of the clinics said that if they don't see any red flags and the child and parents are in agreement, they are comfortable prescribing puberty blockers or hormones based on the first visit, depending on the age of the child. “For those kids, there's not a value of stretching it out for six months to do assessments,” said Dr Eric Meininger, senior physician for the gender health program at Riley Hospital for Children in Indianapolis. “They've done their research, and they truly understand the risk.”2020 Finnish studyhttps://pubmed.ncbi.nlm.nih.gov/31762394/Those who did well in terms of psychiatric symptoms and functioning before cross-sex hormones mainly did well during real-life. Those who had psychiatric treatment needs or problems in school, peer relationships and managing everyday matters outside of home continued to have problems during real-life. … Medical gender reassignment is not enough to improve functioning and relieve psychiatric comorbidities among adolescents with gender dysphoria. Appropriate interventions are warranted for psychiatric comorbidities and problems in adolescent development.Jack Turban misinterpreting it:https://archive.ph/wip/x6LGWGIDS study comparing a group of kids with serious mental health problems who were delayed access to youth gender medicine to a group of kids who were able to start sooner because their mental health was solid enoughhttps://pubmed.ncbi.nlm.nih.gov/26556015/Severely distorted UW study also found no improvement among kids who went on youth gender medicineYet another study out of GIDS, on kids from 12 to 15 years old who went on blockers, found no mental-health improvements, full-stophttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243894Littman defends Littman's research methodshttps://link.springer.com/article/10.1007/s10508-020-01631-zThat dumb chartWe also have chartshttps://www.newscientist.com/article/mg21929361-000-multiple-personalities-takedown-of-a-diagnosis/http://www.fmsfonline.org/?ginterest=RecoveredMemoriesInTheCourts“Another significant issue raised with us is one of diagnostic overshadowing – many of the children and young people presenting have complex needs, but once they are identified as having gender-related distress, other important healthcare issues that would normally be managed by local services can sometimes be overlooked.”https://cass.independent-review.uk/wp-content/uploads/2022/03/Cass-Review-Interim-Report-Final-Web-Accessible.pdfNHS changes course on the safety/reversibility of blockers in 2020https://www.transgendertrend.com/nhs-no-longer-puberty-blockers-reversible/[Michael Hobbes got mad at me for posting this because he doesn't like Transgender Trend, but holy hell is that stupid: They are simply summing up and putting into writing a change to the NHS website, and they're citing a BBC report on the same subject. -Jesse]OLD LANGUAGE: The effects of treatment with GnRH analogues are considered to be fully reversible, so treatment can usually be stopped at any time after a discussion between you, your child and your [multidisciplinary team]NEW LANGUAGE: Little is known about the long-term side effects of hormone or puberty blockers in children with gender dysphoria. Although the Gender Identity Development Service (GIDS) advises this is a physically reversible treatment if stopped, it is not known what the psychological effects may be. It's also not known whether hormone blockers affect the development of the teenage brain or children's bones. Side effects may also include hot flushes, fatigue and mood alterations.Serious Lupron side effectshttps://www.statnews.com/2017/02/02/lupron-puberty-children-health-problems/For years, Sharissa Derricott, 30, had no idea why her body seemed to be failing. At 21, a surgeon replaced her deteriorated jaw joint. She's been diagnosed with degenerative disc disease and fibromyalgia, a chronic pain condition. Her teeth are shedding enamel and cracking. None of it made sense to her until she discovered a community of women online who describe similar symptoms and have one thing in common: All had taken a drug called Lupron. Thousands of parents chose to inject their daughters with the drug, which was approved to shut down puberty in young girls but also is commonly used off-label to help short kids grow taller. The drug's pediatric version comes with few warnings about long-term side effects. It is also used in adults to fight prostate cancer or relieve uterine pain and the Food and Drug Administration has warnings on the drug's adult labels about a variety of side effects. More than 10,000 adverse event reports filed with the FDA reflect the experiences of women who've taken Lupron. The reports describe everything from brittle bones to faulty joints. In interviews and in online forums, women who took the drug as young girls or initiated a daughter's treatment described harsh side effects that have been well-documented in adults.Caroline Jemsbyhttps://www.journalismfund.eu/journalists/carolina-jemsbyGULDSPADENhttps://archive.ph/wip/GFuryClip in questionhttps://drive.google.com/file/d/1bL4WWMCs46dCKweZzz0gBj1AqE62k3oj/view?usp=sharingFull unlocked interview with JesseGLAAD is glad journalists are falling in linehttps://www.glaad.org/blog/jon-stewart-sets-record-straight-gender-affirming-carehttps://www.glaad.org/blog/john-oliver-explains-why-gender-affirming-care-is-so-importantBut sometimes nothttps://www.glaad.org/gap/jesse-singalJesse's response to the original version of his page (he hasn't yet responded to the new one, which went up after this, because life is short): The TikTok Doc yeets some teetshttps://www.nytimes.com/2022/09/26/health/top-surgery-transgender-teenagers.htmlWhoops:Dr. Gallagher of Miami said that she follows up with patients for up to a year. “I can say this honestly: I don't know of a single case of regret,” Dr. Gallagher said in May, adding that regret was much more common with cosmetic procedures. But one of her former top surgery patients, Grace Lidinsky-Smith, has been vocal about her detransition on social media and in news reports. “I slowly came to terms with the fact that it had been a mistake born out of a mental health crisis,” Ms. Lidinsky-Smith, 28, said in an interview.So basically, these clinicians are claiming top surgery has incredibly low regret rates, but they're simply not bothering to keep in touch with their patients. And one year is not very long for followup on this — if you give a kid top surgery at 15 or 16, one of the questions is whether, as their peers sexually develop and start families, they'll at some point wish they had breasts. It's a totally natural, important question, and you can't answer it if your patients are disappearing into the void just one year after you perform surgery on them.Age guidelineshttps://www.cdc.gov/hiv/policies/law/states/minors.htmlOliver: So the benefits of providing care are immense and the risks of withholding it are dire. A survey of around 28,000 trans people found that of those who wanted hormone therapy and didn't receive it 58% reported suicidal thoughts in a given year, which is why the three major professional associations of Child and Adolescent doctors, psychologists and psychiatrists have endorsed gender affirming care and condemned efforts to deny it. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261039This study is ridiculous and doesn't even show any correlation between access to hormones and improvement on the more serious suicide measures anywayOliver: You may have seen or heard from a small subset of people who D transitioned but it is worth noting such cases are rare and highly individualized. Studies show an average of just 2% of people who transition expressed regret. And the vast majority of those who have opted to detransition did so not because of changes in their gender identity but due to external factors such as stigma and lack of social support. Supposedly 1% - 2% regret ratehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099405/Lost to follow datahttps://docs.google.com/spreadsheets/d/1Yog0cUgVufxoTY64q-ll1wr7XcBhuqKD/edit?usp=sharing&ouid=102378063559486309340&rtpof=true&sd=trueOliver is relying not on a study of detransitioners, but on individuals who currently identify as transhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213007/Littman study of detransitionershttps://pubmed.ncbi.nlm.nih.gov/34665380/Reasons for detransitioning were varied and included: experiencing discrimination (23.0%); becoming more comfortable identifying as their natal sex (60.0%); having concerns about potential medical complications from transitioning (49.0%); and coming to the view that their gender dysphoria was caused by something specific such as trauma, abuse, or a mental health condition (38.0%). Homophobia or difficulty accepting themselves as lesbian, gay, or bisexual was expressed by 23.0% as a reason for transition and subsequent detransition. The majority (55.0%) felt that they did not receive an adequate evaluation from a doctor or mental health professional before starting transition and only 24.0% of respondents informed their clinicians that they had detransitioned. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.blockedandreported.org/subscribe
Many people understand that a healthy diet can contribute to good health, but people might be less aware of how their diet can impact their future child's health. Pregnancy is a very sensitive period in which the behavior and diet of a mother can leave a lasting impact on her child. For example, studies show that Israeli children have an 81% lower rate of peanut allergies than their Western counterparts. This trend might be due to the widespread consumption of a popular peanut-flavored snack called Bamba during pregnancy and early childhood. Studies also demonstrate that consumption of folate, also known as vitamin B9, is associated with positive birth outcomes. Dark leafy vegetables, whole grains, peanuts, sunflower seeds, fresh fruits, liver, and seafood naturally contain folates. Mothers with a folate-poor diet during pregnancy have an increased risk of having a child with neural tube defects (NTDs) and other cognitive impairments. NTDs are severe birth defects that can cause serious health issues. On average, about 1-2 in every 1000 pregnancies are affected by NTDs. Therefore, many pregnant women take folate supplements throughout their pregnancy.
This episode features Emerson Rogers, the NTD case management lead in the Ministry of Health Liberia and Eric Whey, the mental health and psychosocial coordinator for Grand Bassa County Health Team, Liberia. Together they discuss how Neglected Tropical Diseases (NTDs) and mental health services are being integrated at the primary health care level and the importance of advocating for sustained services for tackling mental health more generally. Tosin Adekeye, our co-host for this series discusses the cultural, logistical and community aspects that are being considered and the lessons that could be applied in other similar contexts. Dr. Oluwatosin Adekeye Assistant Director of Clinical Psychology, Department of Psychiatry Ahmadu Bello University Hospital Zaria Kaduna A social scientist with varied experience in both clinical and research aspects of health among communities in Northern Nigeria. As a Clinical Psychologist, his work has been both on mental and behavioral disorders and the effects of chronic disease on the well-being of patients and caregivers. As a Social Scientist, he just concluded a study that documented the well-being of people with stigmatizing skin diseases and established a care and support group within the community. More recently he is working on developing a well-being tool for parents and children with disability. Twitter: @TosinOluw, @Sightsavers Eric T. Weah Mental Health and Psychosocial support pillar lead for EBOLA and the COVID 19 RESPONSE, lecturer at the Grand Bassa Community College. The mental health department (MHD) is part of the community health department and works with programs to consider a more holistic biopsychosocial approach. This approach seeks to look at the psychological impact that a condition will have on an individual, the family, the community and society at large. It also provides services for the vulnerable groups such as people living with disability, those in prison and at-risk youth. The mental health department also developed the user group and collaborative approach with faith based organisation, traditional healers and religious leaders to help in improve mental health care. The MHD also works with the Community Health Focal persons to ensure community health workers identify, follow up and refer cases to service delivery point for management. Emerson Rogers National Coordinator for Case Management of Neglected Tropical Diseases (NTDs) Management Committee member- REDRESS Ministry of Health, Liberia Mr Emerson Rogers has a key role in the Management Committee of REDRESS providing ongoing guidance and support as the National Coordinator for Case Management NTDs in Liberia. He manages the coordination of all Case Management, project planning, implementation, supervision, research, and timely reporting of progress. Enforcing strategies to ensure adherence to timely interventions for NTDs. Emerson has 14 years' experience working as a Ministry of Health clinician in Liberia in several hospitals. He served as Clinical Coordinator at the National Ebola Treatment Unit and served as Master Trainer Team Lead for Keep Safe Keep Serving. Emerson served as National Program Director for the Men's Health Screening Program- MOH between 2015-2017. He worked alongside WHO and CDC UK and was responsible for conducting Real Time PCR testing of the semen of Ebola survivors to determine it contained fragments of the virus and therefore help to get a better understanding of the persistence of the virus in the semen of male survivors. Twitter: @redress_liberia
In this week's episode we hear from two community health workers about the work they have been doing to improve mental health services for people affected by neglected tropical diseases (NTDs) as part of the https://www.redressliberia.org/ (REDRESS) programme in Liberia. Satta Sonnie Kollie in Lofa County, Liberia is a community health services supervisor and peer researcher; and Harrison Wenjor in Grand Gedeh, Liberia is the focal person for TB and people affected by NTDs. They discuss the importance of using local dialect, and being a trusted member of the community, especially when talking about mental health and providing counselling to people affected by chronic health conditions. Satta Sonnie Kollie Community health services supervisor and coresearcher, Government of Liberia – Lofa County/REDRESS I am Satta Sonnie Kollie from Lofa County, Liberia. I am Community health services supervisor and coresearcher. I am responsible to supervise the Community health assistants under clinic, give health education to our people in the communities, increasing facility delivery and also making our various communities to know the importance of their good health. D. Harrison Wenjor Former Focal Person for TB, Grand Gedeh, Formerly Government of Liberia – Grand Gedeh County/REDRESS D. Harrison Wenjor has spent many decades working in community health in Grand Gedeh. He worked as the focal person for TB and has worked closely with people affected by various neglected tropical diseases. He is passionate about community health and improving access to health, particularly for the most marginalised. https://www.redressliberia.org/ (https://www.redressliberia.org/) Twitter: @REDRESS_Liberia Transcript available https://bit.ly/3cwoK2m (here)
In this week's episode we hear from Emmanuel Zazay who is a peer researcher in the REDRESS programme and is affected by Buruli Ulcer, a neglected tropical disease. He shares with us the value of learning new skills, through becoming a co-researcher, which has helped him better connect with his community and contribute to the improvement of medical and psychosocial services for people living with NTDs. Emmanuel Zazay Co-researcher, REDRESS I am Emmanuel Zazay from Lofa County, Voinjama District. I work with REDRESS as a coresearcher and I was recruited as a patient affected person as I was diagnosed with Buruli ulcer. I also serve as a data collector, I work in photovoice settings and participatory methods such as bodymapping and focus group discussions. Currently, I am with the coresearcher team in Lofa County. https://www.redressliberia.org/ (https://www.redressliberia.org/) Twitter: @REDRESS_Liberia Fasseneh Zeela Zaizay REDRESS Country Director, Actions Transforming Lives/REDRESS Mr Fasseneh Zeela Zaizay serves as the Liberian Country Program Manager for REDRESS, providing overall management for the project in Liberia. Zeela holds B.Sc. in Nursing (Magna Cum Laude), master's in public health, Diploma of Advanced Studies in Health Care Management, and certificate in monitoring and evaluation. Zeela co-designed Cuttington University's clinical outreach program and served as its coordinator as well as lectured nursing for 7 years. Before joining REDRESS, he served as the Liberian Country Director of MAP International and Technical Assistant to the Ministry of Health. In those roles, he engaged in strengthening the Liberian health system, supporting the integration of NTDs into the health system, and conducting research on health system strengthening and NTDs. He is a co-creator of the Liberian Strategic Plan for the Integrated Management of NTDS. He is a co-founder of Actions Transforming Lives, a registered Liberian charity and partner on REDRESS also providing financial and technical support to the Ministry of Health NTDs Program, as well as giving less fortunate communities access to safe water and improved livelihoods. https://www.redressliberia.org/about-us/people/actions-transforming-lives/fasseneh-zeela-zaizay/ (https://www.redressliberia.org/about-us/people/actions-transforming-lives/fasseneh-zeela-zaizay/) Twitter: @REDRESS_Liberia Twitter: @FZZaizay
Shirika la Umoja wa Mataifa la afya ulimwenguni, WHO, liko kwenye mchakato wa kubadilisha jina la ugonjwa wa ndui ya nyani au Monkeypox. Msemaji wa WHO huko Geneva, Uswiwi, Fadéla Chaib, amethibitisha hayo alipoulizwa swali na waandishi wa habari jumanne ya Agosti 17, 2022 kuhusu mchakato huo. Bi. Chaib amesema ni wajibu wa WHO na mfumo wake wa kubainisha magonjwa kufanya hivyo, “hivyo katika kupatia majina magonjwa, WHO inafanya mashauriano ya wazi kupata jina jipya la ndui ya nyani.” Amesema mtu yeyote wa kawaida, taasisi za elimu, mashirika ya kiraia anakabirishwa kupendekeza jina jipya, kuna jukwaa kwenye wavuti wa WHO ambako watu wanaweza kupendekeza majina. Bi. Chaib amesema ni vema sana kupata jina jipya la ugonjwa wa ndui ya nyani kwa kuwa ni njia bora kutokosea kabila, ukanda, nchi au mnyama na kadhalika. Kwa hiyo WHO ina hofu kubwa juu ya hili hivyo tunatafuta jina lisilonyanyapaa.” Kwa nini kubadili ndui ya nyani na si magonjwa mengine? Amefafanua kuwa hadi sasa hakuna muda kamili wa kupata jina hilo na kwamba iwapo jina jipya likipatikana umma utajulishwa. Alipoulizwa ni kwa nini jina la ndui ya nyani linaonekana kuwa linanyanyapaa na hivyo libadilishwe, Bi. Chaib amesema kwa miaka kadhaa imekuwa ni utamaduni wa WHO kuhakikisha majina ya magonjwa hayaleti unyanyapaa kwa ukanda, nchi au kabila au mnyama na kwamba kwa sasa wanamulika ndui ya nyani. Ndui ya nyani iko tangu mwaka 1958 Ugonjwa wa ndui ya nyani uligundulika kwa mara ya kwanza mwaka 1958 na umekuwa umejikita Zaidi katika nchi za Afrika hadi mlipuko wa mwaka huu wa ndui ya nyani ambapo wagonjwa wameripotiwa nchi za Ulaya. Tarehe 23 mwezi uliopita wa Julai, WHO ilitangaza kuwa ndui ya nyani ni dharura ya afya duniani na tishio la afya ya umma. Kwa mujibu wa WHO, ndui ya nyani iliwekwa kwenye kundi la magonjwa ya kitropiki yanayopuuzwa, NTDs.
For more than 20 years she's been co-chair of the world's largest private foundation, The Bill and Melinda Gates Foundation, which works with projects aiming to fight poverty, inequality and infectious diseases. For years the foundation has poured billions of dollars into global health, education for girls among many others. And at a recent gathering in Kigali, The Bill and Melinda Gates foundation committed money to a $4 billion pledge to help eradicate malaria and neglected tropical diseases – NTDs - which haven't received as much attention in the past. In a wide raging interview, Alan Kasujja speaks with Melinda French Gates to learn more about the causes close to her heart, who she is and what drives her. Host: Alan Kasujja Guest: Melinda French Gates
The AFP test of the Alpha-Fetoprotein Test is a blood test done in the second trimeter of pregnancy screening for nerual tube defects (NTDs). This maternal serum along with ultrsasound screening has led to identification of nerual tube defets in most pregnancies, allowing parents to make decisions about pregnancy management. Neural tube defects are birth anomalies that can develop when a portion of the neural tube fails to close normally during the fifth and sixth weeks of pregnancy. This failure to close can result in a defect in the spine along the vertebrae, spinal cord, cranium, or brain. Several advancements have been made in recent decades to reduce the incidence of NTDs mainly including the supplement folic acid into the diets of pregnant women throught food fortification and prenatal supplements. In this episode, we review what you need to know before your AFP test. We'd love to hear your feedback or hear from you in general. Please send us a question or a comment on our website www.truebirthpodcast.com. You can send us topic suggestions or leave a review. Our practice website can be found at: Maternal Resources: https://www.maternalresources.org/ Remember to subscribe wherever you get your podcasts. Please consider leaving us a review on iTunes Our Social Channels are as follows Twitter: https://twitter.com/integrativeob YouTube: https://www.youtube.com/maternalresources IG: https://www.instagram.com/integrativeobgyn/ Facebook: https://www.facebook.com/IntegrativeOB
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Open Philanthropy Shallow Investigation: Civil Conflict Reduction, published by Lauren Gilbert on April 12, 2022 on The Effective Altruism Forum. Editorial note on this document This document is a “shallow” investigation, as described here. Over the last few years, we've moved towards trying to do more shallows quickly for internal audiences. We wanted to experiment with sharing more again to see how much work it takes and whether it generates informative feedback or leads, so this is the first shallow we've published in a number of years. This is a shallow on reducing civil conflict. It took me about two weeks to write. During this time, I read major papers in the field and spoke to about five experts, but did not fully critique their assumptions. I have tried to flag my major sources of uncertainty in the document. This document has been read and discussed by the cause prioritization team. At this point, we do not plan to proceed to a medium investigation, but that could change if we substantially update our estimates of either the financial costs of civil war or the tractability of the problem. We welcome comments either posted to the EA Forum, emailed to me at lauren@openphilanthropy.org, or shared to this Google Form (can be submitted anonymously). Major sources of uncertainty My major sources of uncertainty after writing this are the following: What is the best way to model the economic impact of civil war? I tended to make fairly conservative (in the sense of total size of the problem) assumptions – e.g. economies that experience civil war recover fully within ten years – but I am not sure how reasonable those assumptions are. We're currently hiring some academics to investigate these questions further. Am I fully capturing the health impacts of civil war on civilians? There is relatively little data about the social or economic consequences of being displaced within the Global South, and I am not sure my estimates of off-battle-field DALYs are particularly good. Fundamentally, I am quite uncertain how much of a difference micro-scale interventions like cognitive behavioral therapy will make on macro-scale events like war. Summary What is the problem? Living through a civil war is very bad for your health. The direct cost of civil conflict is about 10M DALYs per year, but the indirect cost probably quadruples that figure. (This is a fairly conservative estimate; one paper argues that there are 25x as many indirect deaths as there are direct deaths.) Infant mortality and malnutrition rates are twice as high in states either experiencing or recovering from civil conflict as in stable ones. Life expectancy is about a decade lower than would be expected in a peaceful state. Per my BOTEC, civil wars cause a loss approx. ⅔ as many DALYs per year as malaria and NTDs (combined). A civil war costs about $14,000 OP value per country resident per year, or 0.14 life years. (Malaria, by contrast, has a DALY burden of 0.038 life years / resident of sub-Saharan Africa - so civil wars are not as significant a burden on life as malaria, but not insubstantial either, at least in countries where they are ongoing.) But war's impacts are not limited to health. War impoverishes the populations that experience it, such that poverty is increasingly concentrated in and around states experiencing civil conflict. By 2030, about ⅔ of the global extreme poor will live in such states. This is not simply because poverty is declining elsewhere; an increasing percentage and an increasing number of the global poor live in countries either at war or at high risk of descending into war. Most of these wars are not wars of global importance; no major power has any particular investment in settling them. (Indeed, for the purposes of this shallow, I am choosing to focus on civil wars where great pow...
In this edition: How the Kigali declaration is hoped to speed up the fight against neglected tropical diseases that affect 20 percent of the world's population and: While they promise jobs, international projects in Mexico often divide communities.
The LabOpp Global Leaders podcast is a series of conversations about Careers, the Lab Industry, Training, and People. Our guest this week is Joseph Kwaghga Kumbur from Nigeria. He has been working diligently on eradicating Neglected Tropical Diseases (NTDs) across Nigeria. In addition to learning about his journey, tune in to learn more about NTDs and gain an understanding of the current and future state of a variety of diagnostic techniques used in identifying NTDs. If you would like to get in touch with Joseph Kwaghga Kumbur, you can find him on LinkedIn Some of the organizations mentioned during this podcast: · The Carter Center: https://www.cartercenter.org/countries/nigeria.html · Nigerian Institute of Medical Research: https://nimr.gov.ng/ · Helen Keller International: https://www.hki.org/ · Evidence Action: https://www.evidenceaction.org/ · Christian Blind Mission: https://www.cbm.org/in-action/inclusive-eye-health/neglected-tropical-diseases/ If you have suggestions for future guests or comments about this podcast, please visit us at labopp.org/podcast --- Send in a voice message: https://podcasters.spotify.com/pod/show/labopp/message
In this episode we talk to Shahreen Chowdhury and Motto Nganda about their toolkit for participatory health research methods “Supporting Equitable Partnerships in Global Health”. This toolkit presents a whole host of methods which can be used and adapted to connect with communities. https://countdown.lstmed.ac.uk/sites/default/files/centre/Participatory%20Health%20Research%20Methods%20toolkit.pdf (https://countdown.lstmed.ac.uk/sites/default/files/centre/Participatory%20Health%20Research%20Methods%20toolkit.pdf) Dr Akinola Oluwole Dr Akinola Oluwole is an experienced researcher with a special interest in socio-epidemiology of tropical infectious diseases. His multidisciplinary expertise includes spatial disease mapping, monitoring and evaluation of intervention and control programmes and implementation/Health systems research for public health and disease control. He has over Fifteen years' experience working on Neglected Tropical Diseases (NTDs). Recently, Dr Akinola was the programme lead for two Co-production research projects within the COUNTDOWN consortia, one to develop a care package for Female Genital Schistosomiasis and a second to improve the equity of mass drug administration in Nigeria. Both projects utilized innovative Participatory Health Research methods to generate evidence-based information on how to effectively tackle implementation challenges for NTD programme in Nigeria. Dr Akinola has strengthened the capacity of health systems actors, NTD implementers and researchers through training, mentorship and the development of practical guidelines and policy. He is passionate about influencing policy change in Nigeria and Internationally to reduce inequities created by NTDS within the poorest communities. https://countdown.lstmed.ac.uk/about-countdown (https://countdown.lstmed.ac.uk/about-countdown) Dr Motto Nganda, Research Assistant, LSTM Dr Motto Nganda is a public health professional and medical doctor with over six years' experience in the management and implementation of public health disease programmes, including Neglected Tropical Diseases (NTDs), Malaria, Tuberculosis and HIV/AIDS; as well as clinical practice in primary health care in Cameroon. Motto also has experience in implementation research, community engagement in health and health systems strengthening in the fields of household air pollution and Neglected Tropical Diseases in low and middle-income countries including Cameroon, Nigeria, and Liberia. Recently, Motto joined the COUNTDOWN consortium at the Liverpool School of Tropical Medicine, a 7-year multidisciplinary research consortium dedicated to investigating and scaling up cost effective and sustainable solutions to control and eliminate neglected tropical medicines in Low- and Middle-income countries. Motto has applied participatory health research approaches and methods to strengthen the capacity of health systems actors and local communities to develop, implement, evaluate, and embed interventions to diagnose, treat and manage women and girls suspected of female genital schistosomiasis at primary healthcare level; and to decentralise planning, management, and implementation of mass drug administration of medicines in Liberia. Motto has increasing interest in strengthening fragile health systems and supporting community health, to contribute to the WHO's universal health coverage roadmap. https://www.lstmed.ac.uk/about/people/dr-motto-nganda (https://www.lstmed.ac.uk/about/people/dr-motto-nganda) https://countdown.lstmed.ac.uk/about-countdown (https://countdown.lstmed.ac.uk/about-countdown) https://www.ariseconsortium.org/about-us/ (https://www.ariseconsortium.org/about-us/) https://www.redressliberia.org/about-us/collaborators/liverpool-school-of-tropical-medicine/ (https://www.redressliberia.org/about-us/collaborators/liverpool-school-of-tropical-medicine/) Shahreen Chowdhury, Research Assistant, LSTM ...
Peter Hotez talks about the global impact and historical context of neglected tropical diseases. He also highlights important developments in mass drug administration and vaccine research and shares why he chose to publish the third edition of Forgotten People, Forgotten Diseases during the COVID-19 pandemic. Ashley's Biggest Takeaways Neglected Tropical Diseases (NTDs) are chronic and debilitating conditions that disproportionately impact people in low- and middle-income countries (LMICs). Many of these diseases are parasitic, such as hookworm infection, schistosomiasis and chagas disease; however, in recent years, several non-parasitic infections caused by bacteria, fungi and viruses, as well as a few conditions that are not infections, including snake bite and scabies (an ectoparasitic infestation), have been added to the original NTD framework (established in the early 2000s). What do most NTDs have in common? High prevalence. High mortality; low morbidity. Disabling. Interfere with people's ability to work productively. Impact child development and/or the health of girls and women. Occur in a setting of poverty and actually cause poverty because of chronic and debilitating effects. Hotez and his colleagues recognized that there is a uniqueness to the NTDs ecosystem, and they began putting together a package of medicines that could be given on a yearly or twice per year basis, using a strategy called Mass Drug Administration (MDA). This involved the identification of medicines that were being used on an annual basis in vertical control programs and combining those medications in a package of interventions that costs about $0.50 per person per year. “Throw in an extra 50 cents per person and we could double or triple the impact of public health interventions,” he explained. Emerging diseases, such as SARS-CoV-2, capture the attention of the public for obvious reasons. They pose an imminent threat to mankind. NTDs are not emerging infections, but they are ancient afflictions that have plagued humankind for centuries and, as a consequence, have had a huge impact on ancient and modern history. One of the reasons we have mainland China and Taiwan today may have been, in part, due to a parasitic infection, Schistosomiasis. Hotez and colleagues at the Texas Children's Center for Vaccine Development have developed a COVID-19 vaccine, based on simple technology, similar to what is used for the Hepatitis B vaccine. They hope to release the vaccine for emergency use in resource poor countries like India and Indonesia. When asked about the timing of the publication of his book, the third edition of Forgotten People, Forgotten Diseases, Hotez acknowledged the difficulty of helping countries understand that NTDs have not gone away. COVID-19 is superimposed on top of them, and the pandemic has done a lot of damage in terms of NTD control. Although social disruption has interfered with the ability to deliver mass treatments, Hotez said that it has been gratifying to see that the USAID and their contractors have responded by putting out guidelines about how to deliver mass treatments with safe social distancing. “As a global society, we have to figure out how to walk and chew gum at the same time,” he said. “We've got to take care of COVID, but we really must not lose the momentum we've had for NTDs because the prevalence is starting to decline and we're really starting to make an impact.”
Shirika la Umoja wa Mataifa la afya ulimwenguni, WHO, leo limezindua jukwaa maalum mtandaoni kwa lengo la kutoa taarifa na kuelimisha umma kuhusu hatari ya kung'atwa na nyoka wenye sumu na wapi waliko nyoka hao hatari zaidi duniani. Shirika hilo linasema watu kati ya 81,000 hadi 137,000 hupoteza maisha kila mwaka kutokana na athari zinaosababishwa na kung'atwa na nyoka wenye sumu. (TAARIFA YA FLORA NDUCHA) Kulingana na taarifa iliyotolewa leo na WHO wakati wa uzinduzi wa jukwaa hilo mjini Geneva Uswis ingawa idadi kamili ya walioumwa na nyoka hadi sasa haijulikani lakini makadirio yanaonyesha kwamba takriban watu milioni 5.4 huumwa na nyoka kila mwaka huku milioni 2.7 kati yao na nyoka wenye sumu kali ambao husababisha athari mbaya kwa mamilioni ya maisha ya watu na wengi wao wakiwa masikini. Mbali ya vifo vya watu hadi 137,000 kila mwaka, kuumwa na nyoka pia kumewaacha mamilioni ya watu na vilema vya maisha. WHO inasema kuumwa na nyoka mwenye sumu kali kunaweza kusababisha kupooza ambako kunaweza kumzuia mtu kupumua, kumsababishia maradhi ya kutokwa na damu, matatizo ya figo yasiyoweza kutibika na kuharibu mishipa ambayo inapelekea ulemavu wa maisha na kukatwa viungo. Shirika hilo limeongeza kuwa kuumwa na nyoka ni moja ya magonjwa yaliyopuuzwa NTDs ambayo athari zake ni kubwa na mbaya kuliko inavyodhaniwa. Waathirika wakubwa ni watu wanaofanyakazi katika sekta ya kilimo na watoto huku maeneo yaliyoathirika na kuwa hatarini zaidi ni Afrika, Asia na Amerika ya Kusini katika maeneo ya kijijini Mathalani barani Asia watu wapatao milioni 2 hudhurika na sumu ya nyoka kila mwaka na Afrika watu 435,000 hadi 580,000 huhitaji matibabu kila mwaka baada ya kuumwa na nyoka. Kwa mujibu wa WHO ili kupunguza idadi ya vifo na ulemavu utokanao na kuumwa na nyoka mosi ni lazima kuziwezesha na kuzishirikisha jamii, pili kuhakikisha kuna matibabu salama na yenye ufanisi, tatu kuimarisha mifumo ya afya na nne kuongeza ushirika, uratibu na rasilimali za kupambana na zahma hii.
This episode is a bit different to the previous ones because neglected tropical diseases (NTDs) have treatments, so their biology is not beyond the horizon of science. However, in sharp contrast to how curable they are, 1.7 billion people still suffer their effects, and few of the general public elsewhere are aware of the terrible socioeconomic problem they present. In this episode I discuss what neglected tropical diseases are, how they devastate communities, and why they persist despite the effective treatments available. Then I shift to a message of hope, documenting the work of the past and ending with faith in global collaboration.https://whatwedontknow.buzzsprout.com/
Join me in todays episode where I discuss carb cycling and why we would look to put more carbohydrates in on training days (TDs) and non training days (NTDs). I go into why this might be beneficial if you are in a gaining phase or in a dieting phase and why. Follow me on insta: @vwphysique
Ellen Agler is CEO of the END Fund, a philanthropy-backed initiative working to bring an end to the five most common neglected tropical diseases. She joins the Impact Room to talk progress, pooled giving, and the decolonisation of global health. Neglected tropical diseases (NTDs) affect more than 1.7 billion of the world's poorest people, blighting communities from Africa to the Americas. These diseases blind, maim and disfigure their victims, keeping children out of school, adults out of work, and trapping families in poverty. Yet most are preventable or treatable.Founded in 2012, the END Fund is a philanthropic initiative dedicated to ending five of the most common NTDs. A pooled fund, it invests money in support of treatment and surgeries, as well as to train health workers, educate communities and fast-track progress towards disease elimination goals. Ellen Agler is the END fund's founding CEO. She's a TED speaker, a published author, and she serves on the World Economic Forum's Global Health Security Advisory Board. In 2019. Ellen was named by Fortune magazine as one of the world's 50 greatest leaders.In a wide-ranging conversation, Ellen looks back at a decade of the END Fund's work, and opens up about the challenge of last-mile disease elimination, the value of pooled giving, and activist philanthropy.The Impact Room is brought to you by Philanthropy Age and Maysa Jalbout. Find us on social media at @PhilanthropyAge.
The central nervous system (CNS) comprising the brain and spinal cord is an incredibly complex part of the human body, so it is no surprise that sometimes things go awry during development. The various anatomic anomalies that result can be so severe as to be incompatible with life, such as when most or all of the brain fails to develop, a condition known as anencephaly. CNS anomalies are some of the most common congenital anomalies, and they are among the leading causes of infant mortality and fetal loss. These anomalies can involve brain, spinal cord, and meningeal development and position. Although the brain and spinal cord each arise from the neural tube, their development differs. The end result is that the spinal cord is fairly uniform in structure throughout its length, but the brain subdivides into multiple regions, each with its own structure. Accordingly, congenital anomalies of the spinal cord are similar anywhere along its length, but congenital anomalies of the brain are different in different brain regions. We'll discuss CNS congenital anomalies in terms of those that can involve both brain and spinal cord (neural tube defects [NTDs]), those that involve the cranial parts of the brain (forebrain anomalies), those that involve the caudal parts of the brain (posterior fossa anomalies), and those that involve the spinal cord, as well as congenital hydrocephalus. After listening to this AudioBrick, you should be able to: Describe the main anatomic feature shared by the neural tube defects, and list some of the known etiologies. Compare and contrast the anatomic and clinical features of spina bifida occulta, meningocele, meningomyelocele, and myeloschisis. Describe the mechanisms that lead to defects of the skull. Describe the main mechanism that leads to forebrain abnormalities. Discuss the anatomic and clinical features and treatment of congenital hydrocephalus. Describe the mechanism that leads to defects of the cerebellum and brainstem. Describe the mechanism that leads to defects of the spinal cord, and discuss the anatomic and clinical features of syringomyelia. You can also check out the original brick from our Neurology and Special Senses collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks. After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology. *** If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts. It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/ from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks. After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.
New research from The Lancet Diabetes & Endocrinology journal shows current body mass index [BMI] guidance is outdated and dangerous for people from different ethnic groups. The study's principal investigator, Dr Rishi Caleyachetty unpicks the global implications of his findings. Maria Rebollo Polo – WHO lead for Neglected Tropical Diseases in Africa – explains the important task of mapping NTDs like Trachoma. Plus Khadidiatou Cisse reports from Benin on Trachoma – one of the oldest known infections and a leading cause of preventable blindness worldwide. And, have our memories really got worse during the pandemic? Professor Catherine Loveday of Westminster University discusses her new research on our memories during lockdown. Guest: Dr Ann Robinson Presenter: Claudia Hammond Producer: Erika Wright (Picture: Female doctor weighing senior patient at medical clinic. Photo credit: Jose Luis Pelaez/Getty Images.)
New research from The Lancet Diabetes & Endocrinology journal shows current body mass index [BMI] guidance is outdated and dangerous for people from different ethnic groups. The study’s principal investigator, Dr Rishi Caleyachetty unpicks the global implications of his findings. Maria Rebollo Polo – WHO lead for Neglected Tropical Diseases in Africa – explains the important task of mapping NTDs like Trachoma. Plus Khadidiatou Cisse reports from Benin on Trachoma – one of the oldest known infections and a leading cause of preventable blindness worldwide. And, have our memories really got worse during the pandemic? Professor Catherine Loveday of Westminster University discusses her new research on our memories during lockdown. Guest: Dr Ann Robinson Presenter: Claudia Hammond Producer: Erika Wright (Picture: Female doctor weighing senior patient at medical clinic. Photo credit: Jose Luis Pelaez/Getty Images.)
Neglected Tropical Diseases (NTDs) impact almost 2 billion people worldwide, with a disproportionate burden in impoverished communities. While these diseases are considered “neglected” for a variety of reasons, there are some passionate and knowledgeable professionals working to eliminate these diseases which drastically impact the quality of life of many individuals. Dr. Alison Krentel and Maneesh Phillip are two experts united with a shared goal of eliminating NTDs and they continue the conversation with the Public Health Insight Podcast in part 2 of the NTD mini-series. In this episode, they share some of their most impactful career stories from working in the field, challenges and lessons learned from a variety of experiences in different regions, and actionable steps people can take to get more involved in the fight to end the neglect.References for Our Discussion National Institute of Allergy and Infectious Diseases: Neglected Tropical Diseases Quick FactsHotez & Lo (2020) Neglected Tropical Diseases: Public Health Control Programs and Mass Drug AdministrationWorld Health Organization: Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030. BrochureNTD OrganizationsCanadian Network for Neglected Tropical Diseases (CNNTD)effect:hope (The Leprosy Mission Canada)Podcast Guests Dr. Alison Krentel, PhD, MSc, BAManeesh Phillip, MScPodcast Co-HostsLeshawn Benedict, HBSc, MPH, MSc, CAPM®Linda Holdbrook, BSc, MPHGordon Thane, BMSc, MPH, PMP® Share Your Thoughts With Us!Visit our website and follow us on Instagram, Twitter, LinkedIn, and Facebook. We would love it if you shared your thoughts by commenting on our posts, sending us a direct message through social media, or by emailing us at ThePublicHealthInsight@gmail.com. Until then, we’ll see you in the next one.Support Our ShowIf you like our show, feel free to lend us some support by making a contribution on our Patreon page (link below) so we can continue creating the content that you enjoy as we expand the Public Health Insight Community.Music CreditsThe following tracks used in this episode were all produced by Lakey Inspired.Reminisce • Too Bad • New Day • Feels Like Home • Memories With You • My Ride • Fly With Me • Feeling Good • Fast Lane • Cruise W/ Me • Thinking Of You • 4 Hours in Phoenix License: Creative Commons — CC BY-SA 3.0Support the show (https://www.patreon.com/publichealthinsight)
If you found out that there was a set of diseases that affected one in five people around the world and disproportionately affected those living in extreme poverty - maybe you would guess it was due to the big three communicable diseases such as HIV, malaria and tuberculosis, or maybe you would think of noncommunicable diseases like cancer. The reality is you may not have even heard of them because they are considered neglected. Two experts - Dr. Alison Krentel and Maneesh Phillip - join the Public Health Insight Podcast to have a conversation to raise awareness about Neglected Tropical Diseases, otherwise known as NTDs, which contributes significantly to the global burden of disease. References for Our Discussion National Institute of Allergy and Infectious Diseases: Neglected Tropical Diseases Quick FactsHotez & Lo (2020) Neglected Tropical Diseases: Public Health Control Programs and Mass Drug AdministrationWorld Health Organization: Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030. BrochureNTD OrganizationsCanadian Network for Neglected Tropical Diseases (CNNTD)effect:hope (The Leprosy Mission Canada)Podcast Guests Dr. Alison Krentel, PhD, MSc, BAManeesh Phillip, MScPodcast Co-HostsLeshawn Benedict, HBSc, MPH, MSc, CAPM®Linda Holdbrook, BSc, MPHGordon Thane, BMSc, MPH, PMP® Share Your Thoughts With Us!Visit our website and follow us on Instagram, Twitter, LinkedIn, and Facebook. We would love it if you shared your thoughts by commenting on our posts, sending us a direct message through social media, or by emailing us at ThePublicHealthInsight@gmail.com. Until then, we’ll see you in the next one.Support Our ShowIf you like our show, feel free to lend us some support by making a contribution on our Patreon page (link below) so we can continue creating the content that you enjoy as we expand the Public Health Insight Community.Music CreditsThe following tracks used in this episode were all produced by Lakey Inspired.Better Days • Street Dreams • Oceans • Chill Day • Last Night • Feeling Good • Rainy Day • The Dreamer • Beach Dayz • Find A Way • The Process License: Creative Commons — CC BY-SA 3.0Support the show (https://www.patreon.com/publichealthinsight)
In this episode I'm with Gareth Healey from Beyond Noise. Gareth is going to give us some amazing advice on running an agency, selling and what it takes to generate £12 million in revenue. Transcript below. Gareth on LinkedIn: https://www.linkedin.com/in/garethhealey/ Beyond Noise: https://www.beyond-noise.com/ Agency health check: https://agencyhealthcheck.scoreapp.com/ The greatest marketing funnel blog on the internet bar none-
This week we want to turn our attention to crises that don't get the attention they deserve. Take Neglected Tropical Diseases for instance. 1.5 billion people are affected by NTDs, a large number of those in need of treatment are living in Africa. And the war-torn country of South Sudan is in the grip of a humanitarian crisis.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.21.261388v1?rss=1 Authors: Amico-Ruvio, S. A., Paganelli, M. A., Abbott, J. A., Myers, J. M., Kasperek, E. M., Iacobucci, G. J., Popescu, G. K. Abstract: To investigate the role of the N-terminal do-mains (NTDs) in NMDA receptor signaling we used kinetic analyses of one-channel currents and compared the reaction mechanism of re-combinant wild-type GluN1/GluN2A and GluN1/GluN2B receptors with those observed for NDT-lacking receptors. We found that trun-cated receptors maintained the fundamental gat-ing mechanism characteristic of NMDA recep-tors, which includes a multi-state activation se-quence, desensitization steps, and mode transi-tions. This result establishes that none of the functionally-defined NMDA receptor activation events require the NTD. Notably, receptors that lacked the entire NTD layer retained isoform-specific kinetics. Together with previous reports, these results demonstrate that the entire gating machinery of NMDA receptors resides within a core domain that contains the ligand-binding and the channel-forming transmembrane domains, whereas the NTD and C-terminal layers serve modulatory functions, exclusively Copy rights belong to original authors. Visit the link for more info
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.18.210443v1?rss=1 Authors: Mondal, B., Nagesh, J., Reddy, G. Abstract: Human{gamma} D (H{gamma}D) and{gamma} C (H{gamma}C) are double domained crystallin (Crys) proteins expressed in the nucleus of the eye lens. Structural perturbations in the protein often trigger aggregation, which eventually leads to cataract. To decipher the underlying molecular mechanism, it is important to characterize the partially unfolded conformations of Crys proteins. Using coarse grained protein models and molecular dynamics simulations, we studied the role of on-pathway folding intermediates in the early stages of aggregation. The multi-dimensional free energy surface revealed at least three different folding pathways with the population of partially structured intermediates. The two dominant pathways confirm sequential folding of the N-terminal [Ntd] and the C-terminal domains [Ctd], while the third, least favored pathway involves intermediates where both the domains are partially folded. A native like intermediate (I*), featuring the folded domains and disrupted inter domain contacts, gets populated in all the three pathways. I* forms domain swapped dimers by swapping the entire Ntds and Ctds with other monomers. Population of such oligomers can explain the increased resistance to unfolding resulting in hysteresis observed in the folding experiments of H{gamma}D Crys. An ensemble of double domain swapped dimers are also formed during refolding, where intermediates consisting of partially folded Ntds and Ctds swap secondary structures with other monomers. The double domain swapping model presented in our study provides structural insights into the early events of aggregation in Crys proteins and identifies the key secondary structural swapping elements, where introducing mutations will aid in regulating the overall aggregation propensity. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=107 SRC="FIGDIR/small/210443v1_ufig1.gif" ALT="Figure 1"> View larger version (35K): org.highwire.dtl.DTLVardef@fd37e6org.highwire.dtl.DTLVardef@60e7cdorg.highwire.dtl.DTLVardef@128386org.highwire.dtl.DTLVardef@178f240_HPS_FORMAT_FIGEXP M_FIG Graphical Abstract figure C_FIG Copy rights belong to original authors. Visit the link for more info
The rationale for mandatory fortification of flour with folic acid is discussed in this ADC Spotlight podcast. Senior editor of ADC Rachel Agbeko talks to Nicholas Wald and Joan Morris, both from the Population Health Research Institute, St George’s, University of London, about their recent paper which is a response to the 2019 UK Government’s public consultation on the folic acid fortification of flour and grains. They also discuss what products should be fortified and the mean daily folic acid intake increase fortification should achieve across the population. The fortification of flour with folic acid (vitamin B9) should help prevent neural tube defects (NTDs). Read the paper for free on the ADC website: https://adc.bmj.com/content/105/1/6
Innovations in nephrology are taking place as the importance of kidney health is emphasized globally. Listen to this podcast, to hear how kidney care is transforming around the world, with insights from clinicians who share a passion for innovation: Jeffrey Giullian, MD, chief medical officer for DaVita Kidney Care; Janet Cowperthwaite, director of clinical operations for DaVita International; Sam Kant, MD, nephrology fellow at Johns Hopkins Hospital; Szymon Brzosko, MD, chief medical officer for DaVita Poland; Mandy Hale, vice president of nursing for DaVita; Francesca Tentori, MD, vice president of outcomes research and patient empowerment for DaVita, Wisam Al Badr, MD, chief medical officer for DaVita Saudi Arabia; and David Roer, MD, vice president of medical affairs for DaVita Integrated Kidney Care. Listen and read more DaVita Medical Insights here. Podcast Transcript: Ryan Weir: 00:32 Hello, everyone. This is Ryan Weir with the DaVita Medical Insights Podcast. The importance of kidney health is emphasized globally. I've recently caught up both in person and over the phone with nephrology clinicians from around the world to gather an international perspective on kidney care transformation, innovations they're looking forward to seeing within the next decade and more. Ryan Weir: 00:52 In this podcast, we'll hear from clinicians in Poland, Saudi Arabia, England and the United States. We asked Dr. Jeff Giullian, chief medical officer for DaVita Kidney Care; Janet Cowperthwaite, director of clinical operations for DaVita International; and Dr. Sam Kant, nephrology fellow at Johns Hopkins Hospital, what they believe is the next big thing that will improve kidney care in their country. Let's hear what they had to say. Dr. Jeff Giullian: 01:23 We are living through a time of great innovation expansion within kidney care today. I see really a few key innovations coming down the pike that will, I believe, likely change the way that we deliver care in the U.S. and really perhaps across the entire globe. So the first is, within chronic kidney disease, we are seeing innovation in artificial intelligence and predictive analytics, which will help caregivers segment patients based on their risk for renal progression. Dr. Jeff Giullian: 01:52 Second big area is, for patients with end-stage kidney disease, we're seeing innovation that enhances their ability to choose a dialysis modality that best meets their personal needs. This includes items such as home-remote monitoring to all the way to new devices for home dialysis. Then the third thing is that there are mechanisms now to increase the number of kidney transplants. This category really includes everything from paired and chain donations, but also new types of organs and implantable devices that are really a little bit more distant into the future, but they are exciting nonetheless. Ryan Weir: 02:28 Janet Cowperthwaite Janet Cowperthwaite: 02:30 From my perspective, I think it's about patients' engagements and activation. Engagements in their treatment and choices, but also how we run and provide the services, and in other aspects involving them in things like in safety and quality forums within the clinic. Ryan Weir: 02:49 Dr. Kant Dr. Sam Kant: 02:51 I think one of the biggest things is that we so far only relied on one or two blood tests when it comes to diagnosing kidney disease and managing things. I think the emergence of biomarkers, especially, whether they're serum or a urine, any biomarkers, it will probably help us elucidate what kind of acute kidney injury someone has or what kind of disease you know is afflicting the kidneys. I think that would be something that you would see increasing utilization all throughout. Definitely I think has a lot of scope going forward. Ryan Weir: 03:26 Dr. Szymon Brzosko, chief medical officer for DaVita Poland and Mandy Hale, vice president of nursing for DaVita based in the U.S., told us about the one thing that could help improve health care in their respective countries and worldwide. Dr. Szymon Brzosko: 03:41 In Poland, I really would like to see more home renal replacement therapy options being available for patients. Especially I'm thinking about more peritoneal dialysis, it is a valuable one. We have many kinds of treatment options available in my country, but in parallel existing regulations and organizational issues with qualifying patients for being active on the waiting list a problem for potential donor or even social acceptance of these methods is still too low and this is the area where I would like to see you know, improvements and by that probably allowing patients to live better with the disease. Ryan Weir: 04:38 Mandy Hale Mandy Hale: 04:40 I'm going to answer the question as one thing that can improve health care in my community, my country, my world with two answers and that is awareness and preventative care. I think it is so important that, we, as nephrology clinicians, continue to put emphasis on the importance of creating awareness for individuals when it comes to chronic kidney disease, which is so many times and referred to as a silent disease. We must help people understand the risk factors and what type of tests and intervention can help when we refer to CKD and we must provide access to that type of care. I see a whole lot of focus on thinking creatively through helping patients access care or helping individuals understand the risk factor. For me that is just the largest hope I have that we can help read through the presence of chronic kidney disease. Ryan Weir: 05:41 We wanted to hear about the one innovation in kidney care these clinicians believe would create a better future for people with kidney disease. So we asked Dr. Francesca Tentori, vice president of outcomes research and patient empowerment for DaVita, Dr. Wisam Al Badr, chief medical officer for DaVita Saudi Arabia, Dr. Giullian and Dr. Kant for their perspectives. Dr. Francesca Tentori: 06:03 I'll be honest that this is the first time in my life as a nephrologist that I have seen something I'm super excited about. At the last ASN, for example, there were several new dialysis machines and just in general, technology platforms that I thought were really “cool and exciting” and I really envision them to come to fruition sometime in the near future and I think those are good to make a huge difference for our patients. Ryan Weir: 06:39 Dr. Al Badr Dr. Wisam Al Badr: 06:41 One of the most important innovations that we are looking at in the nephrology community today that would bring in the best results for our kidney population is a better screening measure for early detection of kidney failure. Currently, we rely on a blood test including the creatinine and the estimated GFR, but it presents the disease quite late. Finding this measure that presents an early detection of kidney disease would be the best innovation available. Ryan Weir: 07:25 Dr. Giullian Dr. Jeff Giullian: 07:27 I don't believe that there's one single innovation that's the silver bullet at least until we have the ability to provide true regenerative medicine. Rather, I think it's a combination of innovations that will help us slow the progression of kidney disease and then provide many more options for replacing renal function in the event that we can't halt progression of CKD. Ryan Weir: 07:48 Dr. Kant Dr. Sam Kant: 07:50 That's a very interesting question. I think one of the biggest things as a doctor looking after patients who have already undergone transplants, I always feel immunosuppression is necessary, but there's also associated with a lot of side effects and is expensive. There's a big push from centers all over the world to come up with ways by which we can avoid immune suppression all together. They're talking about various STEM cell infusions or modified immune cells infusions, to be more exact. That might help and look very promising in evading immunosuppression all together once patients are transplanted. I think that's of the things I'm really looking forward to. I really hope it works out and it’s certainly I've been going on and on about it, I think it would be a complete game changer. Ryan Weir: 08:42 Dr. David Roer, vice president of medical affairs for DaVita Integrated Kidney Care, Dr. Giullian and Dr. Brzosko provided their thoughts on what the kidney care community is doing well and could impact the rest of health care. Dr. David Roer: 08:55 I think the one thing that the renal care community can do and help as an example for the broader health care community is using robust analytics to organize and develop highly effective and efficient care delivery systems through integrated kidney care team. The kidney care community has been at the forefront of collecting important clinical demographic and financial metrics. Using this information to efficiently and effectively care for patients with chronic kidney disease will be essential in driving towards the goal of reducing chronic kidney disease and slowing the progression of chronic kidney disease. Ryan Weir: 09:43 Dr. Giullian Dr. Jeff Giullian: 09:45 The kidney community in the United States is working to break down silos and reduce fragmentation and care. Now, we're still very far away from achieving that goal. However, as we do improve care coordination and data sharing, I believe this will have a major positive impact on the care that we provide to our patients and will serve as a model for the rest of health care. Really, along these same lines, nephrologists and kidney care providers like DaVita are leading the country in integrative care and value based reimbursement from the ESCOs which were the ESRD or ESKD seamless care organizations to CSNPs, chronic special needs plans to other integrated care arrangements. Kidney care is ahead of the rest of health care in the movement away from volume-based payments and towards value-based payments and I'm very proud of the role that DaVita and our nephrology colleagues have played in this arena. Ryan Weir: 10:37 Dr. Brzosko Dr. Szymon Brzosko: 10:39 First of all, I'm really impressed how the nephrology community was able to take it on and successfully took advantage of the power of social media and other internet platforms for education and nephrology education, sharing knowledge and connecting the kidney community across the world. And by saying this, I mean including students, doctors, medics, scientists and organizing many activities to join like journal clubs, like NephJC to mention, which I really enjoy very much, Neph Madness by American Journal of Kidney Disease, a nephrologist podcast where our community's very active, e-learning activities like NTDS by ASN and smart use of social media like Twitter. It allows people to create a personal and professional social media network. When you start, you actually choose who you follow, it can be really enriching your expert knowledge and experience whatever professional career step you are in and actually many smart people are actually there. Dr. Szymon Brzosko: 11:54 Having my Twitter as an example, these people are willing to discuss, share and talk. Including DaVita teammates, like probably well known for all of us, Dr. Provenzano, Dr. Mahesh Krishnan or CMO for DaVita International, Dr. Partha Das. They are all present there. Oh yes, and to mention our current CMO for DaVita Kidney Care, Dr. Jeff Giullian, is also there. So indeed sometimes it is the field where you can interact with people you tried to contact during, for example, a conference but fail as they are busy or you are too, too far in the line. That's an approach that for sure, I would say, makes nephrology great again. Dr. Szymon Brzosko: 12:39 But probably even more impactful to patients, I would like to mention how the kidney community is supporting educating patients and the patient empowerment idea, and nice examples of that is taking into consideration patient oriented outcomes as an endpoint in nephrology to try it out. This is so much an essential part of the change I see and feel is getting real value in the care we deliver to patients. It’s called patient-centered care, where after explaining the problems, current options, order for treatment, then patient goals, values and patterns to the very center stage. Ryan Weir: 13:30 How do we see the nephrology community changing in the next year? What about within the next decade? Mandy Hale, Dr. Tentori, Dr. Roer and Dr. Kant provided their thoughts. Mandy Hale: 13:41 I'm really excited about the transformation of nephrology care that I think we can expect over the next year and of course well into the next decade. There's so much focus and energy right now around, I would say, three things that I think are going to look a lot different. The first one is preventative care and the focus on really preventing and delaying chronic kidney disease, so I'm so excited for individuals who may have access to care who didn't before or access to different types of care to really look at preventing the need for further intervention as kidney failure progresses. That's one exciting thing. Mandy Hale: 14:27 Secondly, I'm very excited about the focus, the intentional focus, around increasing the presence of home dialysis, home therapies, both peritoneal dialysis and home hemodialysis can be life changing for patients, both through improving their outcomes and their quality of life and the way they feel, but also will really dramatically change the way that nephrology care is delivered. Mandy Hale: 14:56 Then thirdly, I'm also excited about the focus on transplants. I really look forward to further changes, particularly here in the United States that will help make transplant easier; easier for patients to obtain, easier for donors to donate and the increased coordination that will resolve with dialysis and kidney care providers and transplant facilities. Ryan Weir: 15:22 Dr. Tentori Dr. Francesca Tentori: 15:24 I didn't know that it's necessarily changing, but I think there's going to be more and more emphasis of the need to integrate a kidney care across the continuum of the kidney disease spectrum. So, from CKD into dialysis to transplantation towards end of life, integrating all of the stats. That means better communication across clinicians and providers. That's something that is really gaining traction and people are interested in. Ryan Weir: 15:58 Dr. Roer Dr. David Roer: 16:00 Let me start with the second question. I believe, as a nephrologist and part of the renal care community, we would all agree that improving the care of patients with chronic kidney disease to reduce the number of individuals suffering from chronic kidney disease and focusing on a cure rather than on renal replacement therapy is the ultimate goal. This is an exciting time in nephrology that this goal may be achieved within the next decade. The prevalence of chronic kidney disease in the United States is approximately 15% and two thirds of those suffering from chronic kidney disease and end stage kidney disease has concurrent comorbidities of diabetes, hypertension and cardiovascular disease. There are accelerating advances in innovation in the treatment of patients with chronic kidney disease. Recent research has shown evidence that new pharmacologic treatments for diabetes can slow or stop the progression of chronic kidney disease and reduce the cardiovascular risk, mortality and need for dialysis. Dr. David Roer: 17:10 The advancing understanding of the pathophysiology of chronic kidney disease and precision personalized medicine will hopefully change the natural history of chronic kidney disease. The first part of your question, “how do I see nephrology care community changing in the next year?” With the end in mind to reduce or eliminate chronic kidney disease we are organizing the renal care community to achieve this goal. To begin, a focus on new efforts for early detection and treatment of patients with chronic kidney disease through patient education, clinician and caregiver education through building an integrated care delivery infrastructure. Dr. David Roer: 17:58 Furthermore, treating the most common causes of chronic kidney disease including new proven diabetic therapy. Improving education for the broader medical community and patients is an important part of the strategy for early detection and intervention to prevent end stage kidney disease. This strategy will be facilitated by moving from a fee-for-service payment model, to a population value-based payment model. At DaVita, we have been providing integrated kidney care for patients with end stage kidney disease for approximately 20 years and for patients with chronic kidney disease for about 10 years. Through integrated kidney care, it's significant reduction in total cost of care while improving quality of care. Ryan Weir: 18:54 Dr. Kant Dr. Sam Kant: 18:56 In the last year there's been a lot of research that's been happening, especially in nephrology. If you name it, pretty much the SGLT2 inhibitors, the mentor trial, or back to that, you can see that the demand in a research and in nephrology is actually picked up quite a bit. I think that will really spur more studies and of course looking for further answers. I think just the application of what we found with the trials in the last year will really help patients and above all the community. I think that would be something that I would say at least over the next year for sure. I think, more importantly, with more changes that are being implemented in the U.S. for the next decade, I think long term, some good steps have been taken. The encouragement of home therapies is something which is a great step and above all to improve access to transplantation. That will be a game changer. With the way things are going in the communities embracing these changes, the next decade it's going to be extremely exciting. Ryan Weir: 19:59 Our final question for clinicians went to Dr. Roer, Dr. Al Badr, Janet Cowperthwaite and Mandy Hale. We asked each of them to share general tips for their fellow nephrology clinicians. Dr. David Roer: 20:10 I think what's important is to develop partnerships that will enable your practices to expand capabilities to impact the care of patients with chronic kidney disease such as the use of predictive analytics, robust chronic kidney disease, patient education and collaboration with the broader local care community for early detection and intervention with patients with chronic kidney disease. Ryan Weir: 20:39 Dr. Al Badr Dr. Wisam Al Badr: 20:41 The best tips that I would recommend for nephrologists within the Saudi community and the GCC countries would be to develop screening programs for the high risk population. Number two, initiate early vascular access planning for patients who reach a level four and five very close to dialysis to prevent the crashing patients to come into the ER. The third tip that I would really highly recommend is to create an integrated health care system where the patient is involved and is part of the planning and the management of his own personal care. That would bring in that level of buy in that we all recommend for the patient, his family and the treating team. Ryan Weir: 21:48 Janet Cowperthwaite Janet Cowperthwaite: 21:50 So I was lucky last week to have a chance to meet with a small group of patients in the non-clinical care setting and it really opened my eyes to some things. How thoughtful are we? How can we improve how our care team interacts with our patients? After listening to these patients, I've made efforts to better understand and then improve the patients’ journey. Ryan Weir: 22:22 Mandy Hale Mandy Hale: 22:24 I'm going to provide two general tips that I have for other nephrology clinicians. These are very consistent with what I share to nurses that I interact with every day. The first is I can't encourage enough for clinicians in nephrology to be well-rounded in nephrology. I always encourage nurses and other caregivers to really expand beyond the four walls and what's the work in. Don't only know in-center hemodialysis or don't only know the provision of peritoneal dialysis. Challenge yourself to understand in a more global fashion, what all aspects of nephrology care look like, including to take the different dialysis therapies, transplants, the whole general care that can exist for patients. Mandy Hale: 23:20 The second tip that I would offer, is continue your education. I can't encourage clinicians enough to advance their professional practice. This could be of course, obtaining additional clinical education units that are required for licensure or certification, but also stretch yourself further. Obtain a certification in nephrology nursing, for instance which suggests that you are a subject matter expert. It's third party validation that you're an expert for in the field. Obtain additional certifications beyond that or take other classes, attend a conference, whatever that looks like. Advancing professional practice is so important, particularly as nephrology care continues to change. Ryan Weir: 24:05 We want to thank all of the nephrology clinicians who provided their perspectives on kidney care transformation in this DaVita medical insights podcast episode. We hope this gave a closer look at the innovations taking place worldwide. Listeners, thank you so much for tuning in and be sure to check out other DaVita medical insights episodes for more kidney care educational podcasts. You can also find additional kidney care, thought leadership and industry news by following @DaVitaDoc on Twitter. Thanks for listening and we'll see you next time on the DaVita Medical Insights podcast.
There is a category of diseases that sickens, injures and kills the poorest people on the planet. These are called Neglected Tropical Diseases or NTDs You may be familiar with some of them, like leprosy, guinea worm disease or River Blindness; but you have probably never heard of most of them--I know I have not. But these diseases, combined, affect nearly 1.7 billion people around the world and further add to the costs of developing economies. So, in an effort to make these diseases a little less neglected, about eight years ago governments, philanthropies, UN agencies and NGOs came together to design and implement strategies to reduce and ultimately eliminate many of these diseases. On the line with me today is someone who has been at the very forefront of that effort. Dr. Thoko Elphick-Pooley is the director of a collective called Uniting to Combat NTDS. We discuss the progress that has been made towards the elimination of NTDs and also what strategies have been most effective in combating these diseases. As it happens, we spoke on the first-ever World NTD Day, so I kick off asking Dr. Elphick-Pooley about the significance of having a new world day around Neglected Tropical Diseases. https://www.undispatch.com/ https://www.undispatch.com/category/podcast/ https://www.globaldispatchespodcast.com/
Angela Udongwo CEO and Co-Founder of InnoHealth Dx The InnoHealth Dx strives to empower communities to eliminate neglected tropical diseases by supplying innovative solutions to communities that need them the most. InnoHealth's mission is to decrease the rate of schistosomiasis to less than 1% (below sustainable levels) beginning in Kano State, Nigeria. Infectious diseases have been a leading cause of death within tropical areas of the world for centuries. Within these regions, the focal point of healthcare has been tackling malaria, despite there being equal and even arguably higher endemic issues such as schistosomiases. Neglected Tropical Diseases (NTDs) have wreaked havoc on not only the standard of living of the individuals in these parts of the world but have drastically reduced their life expectancy. The gravity of NTDs is further intensified by socioeconomic and educational differences between the individuals suffering from this disease and the individuals equipped to address their suffering.With access to technology at the forefront of healthcare and utilizing cultural competency, InnoHealth will create a more comprehensible prognosis, transferable diagnosis, faster treatment rates, and overall further catalyze not only healthcare but the standard of living in these regions.
Did you know that infectious diseases still impact 0ver 1.5 BILLION people globally? On this episode of Finding Your Frequency, we talk about infectious diseases, hookworms in Alabama, and eliminating neglected diseases. Tune in as we talk with Ellen Agler. Ellen is the CEO of the END Fund, a private philanthropic initiative working to end five neglected tropical diseases (NTDs) affecting 1 in 5 people alive today. She is a member of the World Economic Forum’s Global Health Security Advisory Board and the Uniting to Combat Neglected Tropical Diseases Stakeholders Working Group.
Today’s guest will give us some incredibly inspiring stories about how her organization is ending tropical diseases. My guest is Ellen Agler who serves as the CEO of the END Fund, a private philanthropic initiative working to end five neglected tropical diseases (NTDs) affecting 1.5 billion people—1 in 5 people alive today. She is also a member […]
According to the World Health Organization (WHO), Neglected tropical diseases (NTDs)– a diverse group of communicable diseases that prevail in tropical and subtropical conditions in 149 countries – affect more than one billion people and cost developing economies billions of dollars every year. Populations living in poverty, without adequate sanitation and in close contact with infectious vectors […] The post Neglected Tropical Diseases: Chagas disease and schistosomiasis appeared first on Outbreak News Today.
According to the World Health Organization (WHO), Neglected tropical diseases (NTDs)– a diverse group of communicable diseases that prevail in tropical and subtropical conditions in 149 countries – affect more than one billion people and cost developing economies billions of dollars every year. Populations living in poverty, without adequate sanitation and in close contact with infectious vectors and domestic animals and livestock are those worst affected. On the eve before Christmas eve show this year, I play two interviews about two very important NTDs, both parasitic diseases--Chagas disease and schistosomiasis. Hutchinson Distinguished Professor of Biological Sciences at Loyola University New Orleans, Patricia Dorn, PhD talks about Chagas disease in this Mar. 2017 interview. In the second half, Parasitology teacher and author of the book, Parasites: Tales of Humanity's Most Unwelcome Guests, Rosemary Drisdelle discusses schistosomiasis in this interview earlier this year.
Hello, I’m Thomas Locke and this is Five Minutes, the podcast that brings you closer to the people fighting malaria. Today, I’m joined by Jeremy Lefroy MP, the Chair of the All-Party Parliamentary Group on Malaria and NTDs. Political attitudes are vital to the success of malaria elimination efforts and his responsibility is to inform other Parliamentarians about the disease. Today’s a good time to speak because the group’s annual report was released earlier this week.
Peter Hotez talks about neglected tropical diseases: what are they, where are they found, and where did the term “neglected tropical disease” come from, anyway? Hotez discusses some of the strategies his and other groups are using for vaccine development, and his work as an advocate for childhood vaccines and global health. Host: Julie Wolf Subscribe (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the ASM Podcast app. Julie's biggest takeaways: Renaming “other diseases” - a large collection of disparate diseases such as schistosomiasis, leishmaniasis, and onchocerciasis (also called river blindness) - as “neglected tropical diseases” by Hotez and colleagues was integral to bringing attention to the diseases of the bottom billion, people that live on less than one U.S. Dollar per day. Neglected tropical diseases are often chronic and debilitating without high mortality. These diseases trap people in poverty due to their long-term effects. The NTDs are often associated with terrible stigma that can lead to additional challenges for affected populations. Neglected tropical diseases are found worldwide, in rich and poor countries. The poorest peoples living in the G20 countries (and Nigeria) now account for most of the world’s NTDs. Parasitic infections present challenges for vaccine design, but reverse vaccinology may be a useful strategy. Reverse vaccinology mines genomes to identify promising vaccine candidates in silico, which are then narrowed sequentially for those that are expressed on the bacterial surface, immunogenic, and ultimately protective against disease. This strategy has worked for Neisseria meningitidis, and Hotez is hopeful that it will produce effective vaccines for the parasitic infections he studies. The tradition of individual fields and departments, combined with the old-fashioned notion that scientists needn’t spend their time engaging with the public, has led to flatlined budgets and the rise of anti-science movements. Scientists need to engage the public to ensure the future of science and science-based policy. Featured Quotes (in order of appearance): “The concept of ‘neglected tropical diseases’ was very much born out of the Millennium Development Goals launched in the year 2000.” “Treating NTDs in rich countries “is not a resource problem; it’s an awareness problem.” “If you want to enter global health, we need as many people with a scientific background to go into business and law and international relations as we need to go into traditional scientific pathways” “Many involved in the antivaccine movement disproportionately involve either parents who are affluent or educated, or both: those who know just enough to do a google search but without the background to separate the garbage from the important stuff. And of course the anti-vaccine groups are deliberately misleading.” “Research America found that 81% of Americans can’t name a living scientist. That’s our fault. We’re so inward looking that we aren’t taking the time to do public engagement.” Links for this episode Peter Hotez at Baylor College of Medicine Peter Hotez website Millennium Development Goals published by the World Health Organization in 2000 WHO list of Neglected Tropical Diseases Forgotten People, Forgotten Diseases by Peter Hotez Blue Marble Health by Peter Hotez Public Health United episode featuring Hotez HOM Tidbit: Oncocerciasis now: 1986 British Medical Journal report Send your stories about our guests and/or your comments to jwolf@asmusa.org.
Provides an overview of the Neglected Tropical Diseases (NTDs) with a case-based approach. Addresses the importance of NTDs in global health, clinical features and treatment of select NTDs, tool-ready programs addressing NTDs, and an overview of Mass Drug Administration (MDA).
ACTRESS ALYSSA MILANO TALKS ABOUT PROJECT RUNWAY ALL STARS SEASON 5 PREMIERING ON LIFETIME FEB 11 AT 9PM ET Alyssa Milano is an actress, producer, former singer and author. She is known for her roles in the ABC sitcom Who's the Boss, the Fox soap opera Melrose Place, The WB series Charmed and the ABC drama Mistresses. Currently she is the host and a judge on PROJECT RUNWAY ALL STARS!ABOUT PROJECT RUNWAY ALL STARS:Thirteen of television's most memorable and talented designers make their way back to the workroom to try to sew up a win on season five of Lifetime's hit series Project Runway All Stars, premiering Thursday, February 11 at 9pm ET/PT. The designers will have a new twist to contend with this season as Alyssa Milano, Isaac Mizrahi and Georgina Chapman will be judging an "anonymous runway" for the very first time and won't know which designer created each garment. Zanna Roberts Rassi returns as the designers' mentor.Joining the judges to weigh in on who should win are musicians Ke$ha, Boy George, Little Big Town and actresses Debra Messing, Vanessa Hudgens, Megan Hilty and Debi Mazar. The designers will also face Project Runway's Nina Garcia and Zac Posen, supermodel Coco Rocha, celebrity stylist Johnny Wujek, and TV personalities Kristin Cavallari and Brad Goreski.The winner of Project Runway All Stars Season five will receive the opportunity to design an exclusive line of jewelry for Baublebar.com as well as a capsule collection by Chinese Laundry. The winner also receives a fashion spread in Marie Claire magazine and a position as contributing editor for a year, and a complete sewing studio from Brother Sewing and Embroidery. To top it off, the winner receives a $100,000 grand prize to elevate their business and brand.BIOGRAPHY :Actress Alyssa Milano has spent almost her entire life in the public eye. A famous child actor, she has continued to work throughout her adulthood in both television and film. Currently, Alyssa is the host and a judge on Lifetime's “Project Runway All Stars,” alongside judges Isaac Mizrahi and Georgina Chapman. The new season of the show is set to return in the first quarter of 2016. Alyssa has a history of starring in long running successful television series. She starred on the hit WB series “Charmed” for nine years. The series' debut was the highest-rated premiere in the network's history, and continued to be a great success for Spelling and The WB. The show's international appeal has brought it to more than 100 territories around the world, spanning Europe, Asia, Africa and Australia. She also starred on the Fox cornerstone series “Melrose Place.” She began her career on ABC's “Who's the Boss” which aired for eight years. Alyssa had a recurring role on the hit NBC comedy, “My Name is Earl,” and starred in the ABC comedy, “Romantically Challenged.” Alyssa also starred in the ABC series, “Mistresses.” The sexy drama series followed four women and their sometimes scandalous romantic lives.Alyssa was seen on the big screen in Garry Marshall's “New Year's Eve,” with co-stars Robert DeNiro, Ashton Kutcher, Zac Efron, Michelle Pfeiffer, Hilary Swank and Sarah Jessica Parker and “Hall Pass,” opposite Owen Wilson and Jason Sudeikis. Alyssa's additional film credits include “Hugo Pool” co-starring Sean Penn and Robert Downey Jr., the Imagine/Universal film, “Fear,” and “Dickie Roberts: Former Child Star.” She provided a lead voice for Disney's sequel to the animated favorite “Lady and the Tramp.” She also starred in and produced the independent film “My Girlfriend's Boyfriend.”Her other role is outside the world of Hollywood, as a philanthropist. UNICEF invited Alyssa, in 2003, to become a National Ambassador, recognizing her charitable work on behalf of children. Her first trip with the organization was to Angola, Africa (May 2004) to see first-hand the issues plaguing the newly liberated country. Alyssa followed that trip with a visit to India in June 2005. She is currently working with UNICEF to educate American youth to the issues crucial to that country's evolution. She has worked on UNICEF's pivotal “Trick or Treat” campaign as an official spokesperson, and has plans to work with UNICEF on numerous projects in the future. International relief work is not new to the actress. Alyssa hosted a photography exhibition and auction in 2002, in Los Angeles raising money for charitable efforts in South Africa. An avid photographer, Alyssa displayed her own work, as well as that of school children from L.A.'s Venice Arts program. The event raised close to $50,000 for Nkosi's Haven, an organization that runs care centers in South Africa for AIDS-afflicted mothers and children. Alyssa was honored for her efforts with a humanitarian award from Sri Chinmoy: The Peace Meditation at the United Nations. It was this work that got the attention of UNICEF executives.The Global Network for Neglected Tropical Disease Control (GNNTDC), an alliance of international partnerships based at the Sabin Vaccine Institute in Washington D.C. and formalized by the Clinton Global Initiative to lead the global effort to treat, control and eliminate neglected tropical diseases (NTDs) in the world's poorest countries recently named Alyssa the organization's founding ambassador. Alyssa will continue work to raise awareness of GNNTDC and NTDs among the mainstream media and with the general public. The John Wayne Cancer Institute at Saint John's Hospital and Health Center and the Associates of Breast & Prostate Cancer Studies presented Alyssa with the Spirit of Hollywood Award in 2004, which honors individuals from the entertainment industry for their personal dedication and commitment to making a positive difference in the lives of others. Alyssa also attended the 2004 Democratic National Convention on behalf of the Creative Coalition and is an avid supporter of MTV's Rock the Vote campaign.Alyssa also has her own clothing, jewelry and eyewear line, TOUCH by Alyssa Milano. Launched in the Spring of 2007, TOUCH was born out of necessity. When Alyssa, an avid baseball fan, went to games, she wanted to wear fan gear to support her team, but found that the product mix offered in the marketplace did not address her everyday fashion needs. She felt women should be able to look stylish while cheering on their favorite team. So, she partnered with G-III Apparel Group and Major League Baseball to design and distribute a line of juniors' ladies MLB apparel. The line is not just for baseball fans anymore. She has joined forces with the NFL, NBA, NHL, NCAA, Major League Soccer, Minor League Baseball, The Kentucky Derby and NASCAR, to make TOUCH available to their fans as well.Her book, SAFE AT HOME: Confessions of a Baseball Fanatic (William Morrow), chronicles Alyssa's passion for baseball and how her love for the game has helped shape who she is.She entered the world of graphic novels with the release of “Hacktivist,” a fast-paced cyber-thriller about friendship and freedom in a time of war. The story follows Ed Hiccox and Nate Graft, the young founders of the world's most innovative social media company who moonlight secretly as one of the most notorious black-hat hacker teams on the planet. The second volume was released July 2015. Alyssa is married with a son and a daughter and resides in Los Angeles.
Host: Matt Birnholz, MD Joining host Dr. Matt Birnholz is Sarah Marchal Murray, Chief Operating Officer at The END Fund, a private philanthropic initiative dedicated to controlling and eliminating neglected tropical diseases (NTDs). Over 1.4 billion people globally are affected by one or more of the most common NTDs, including 875 million children. The END Fund focuses on tackling the five most prevalent NTDs: intestinal worms,schistosomiasis,lymphatic filariasis,trachoma, and river blindness.
Host: Matt Birnholz, MD Joining host Dr. Matt Birnholz is Sarah Marchal Murray, Chief Operating Officer at The END Fund, a private philanthropic initiative dedicated to controlling and eliminating neglected tropical diseases (NTDs). Over 1.4 billion people globally are affected by one or more of the most common NTDs, including 875 million children. The END Fund focuses on tackling the five most prevalent NTDs: intestinal worms,schistosomiasis,lymphatic filariasis,trachoma, and river blindness.
Neglected tropical diseases afflict some of the world's most isolated communities. Yet they are not as obscure as many people think – the blinding bacterial disease trachoma existed in the United States and Europe until the early-20th century, and river blindness was brought to the Americas from Africa through the slave trade. Carter Center experts discuss how fighting these horrific, yet preventable diseases impact poverty and improve global health.
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