Podcasts about Nath

Boa terça, angulers! #337 no ar! Abrimos comentando a nova pesquisa Quaest que apontou perda de apoio de Flávio Bolsonaro entre evangélicos, mulheres, jovens, no sudeste, entre outros grupos. Desde março, Lula e Flávio apareciam em empate técnico nas simulações do segundo turno. Agora, Lula abriu vantagem de seis pontos. No segundo bloco, nossas impressões, surpresas, deleites e críticas assistindo à Copa do Mundo. Por fim, pop-ups internacionais: EUA e Irã chegam a acordo de paz, que será assinado na sexta-feira; Peru segue com sua eleição presidencial indefinida e com pedido de recontagem dos votos: Reuni Unido quer proibir o acesso de menos de 16 anos a redes sociais; e a maravilhosa peça “Viva! vida!”, monólogo de Regina Casé com texto de Estevão Ciavatta. Sirva-se!Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Super Rugby Pacific ends in Australia for 2026, not with a bang but a whimper. Nick W and Nath rip the band aid off and sit on the cuck chair to discuss the Reds and Brumbies, before exorcising the bad news by talking Super Rugby Women's and the Aussie 7s win in France. WARNING: bad metaphors and explanationsSee omnystudio.com/listener for privacy information.

Super Rugby Pacific ends in Australia for 2026, not with a bang but a whimper. Nick W and Nath rip the band aid off and sit on the cuck chair to discuss the Reds and Brumbies, before exorcising the bad news by talking Super Rugby Women's and the Aussie 7s win in France. WARNING: bad metaphors and explanationsSee omnystudio.com/listener for privacy information.

Boa terça, angulers! Abrimos o #336 comentando o novo tarifaço imposto por Trump ao Brasil. Ao que tudo indica, vem aí em junho. No segundo Globo, o caso Henry Borel, a condenação de Jairinho e o perdão judicial à Monique. Inacreditável. Por fim, as tensões geopolíticas da copa do mundo já começaram! E as eleições presidenciais extremamente acirradas no Peru. Sirva-se!Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

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A New York Cemetery Was Hiding Over 5 Million Burrowing Bees, One of the World's Largest Concentrations A New York cemetery was hiding 5.5 million bees underground Contact the Show: coolstuffdailypodcast@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Boa terça, angulers! Um #335 recheado de assunto! Abrimos comentando a votação histórica na câmara que aprovou o fim da escala 6x1 e a redução da jornada de trabalho. O texto segue para votação no Senado, ainda sem previsão. No segundo bloco, a visita de Flávio Bolsonaro a Daniel Vorcaro, enquanto o ex-banqueiro ainda cumpria medidas cautelares após sua primeira prisão. Ainda no tema, Cláudio Castro foi alvo de operação que mira aportes em fundos do Banco Master. Além disso, o encontro de Flávio com Trump e a classificação do CV e do PC como organizações terroristas estrangeiras. Por fim, uma passada no primeiro turno das eleições presidenciais da Colômbia e as dicas culturais da semana que incluem a turnê do Martinho da Vila e Martnalia, entre outras. Sirva-se!Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Two Aussie sides are in the finals... but how far will they get? Nick H, Nath and Nick W get honest about the Reds and Brumbies' chances after mixed form over the last few weeks, plus talking Moana Pasifika, victory in the Sevens, and Super Rugby Women's. DKO INSTA: https://www.instagram.com/thedroppedkickoff/ DKO TWITTER: https://x.com/DroppedKickOff_ WARNING: graphic analogies, honest opinions and naughty wordsSee omnystudio.com/listener for privacy information.

Two Aussie sides are in the finals... but how far will they get? Nick H, Nath and Nick W get honest about the Reds and Brumbies' chances after mixed form over the last few weeks, plus talking Moana Pasifika, victory in the Sevens, and Super Rugby Women's. DKO INSTA: https://www.instagram.com/thedroppedkickoff/ DKO TWITTER: https://x.com/DroppedKickOff_ WARNING: graphic analogies, honest opinions and naughty wordsSee omnystudio.com/listener for privacy information.

Subscribe on LiSTNR: https://play.listnr.com/podcast/fifi-fev-and-nickSee omnystudio.com/listener for privacy information.

Boa terça, angulers! Finalmente, chegamos em São Paulo com nosso Angu ao vivo #334. Vivemos uma tarde inesquecível aprendendo e reverenciando o gigante @neilopesoficial. Cantor, compositor, escritor, advogado, dicionarista, ilustrador, poeta, ficcionista, estudioso, um dos maiores intelectuais do Brasil. 84 anos de muita sabedoria. Uma aula de Angu de Grilo. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Send us Fan MailIn this episode, Joe and Nath chat all things winter lawn care — what you should be doing right now, common mistakes to avoid, and how to keep your lawn looking healthy and green through the colder months.They also recap a huge week for Lawn Solutions Australia, including the LSA conference and field day and whats coming up.www.lawnsolutionsaustralia.com.auwww.facebook.com/lawnsolutionsaustraliawww.youtube.com/@LawnSolutionsAustralia

Boa terça, angulers! Abrimos o Angu #333 comentando as mensagens trocadas entre Flávio Bolsonaro e Daniel Vorcaro, que escancaram relação pessoal e íntima entre os dois. No segundo bloco, governo age em busca de popularidade e se recuperada. Por fim, as projeções para o El Nino, que deve começar em junho; a morte de Noca da Portela, aos 93 anos; e as dicas culturais d semana. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Super Rugby is finishing with a flourish. With Nick W off with the tradies, Nick H and Nath chew the fat on the Tahs cleaning up in Suva and the Force chasing a dream... and do some number crunching to see what finals might look like. WARNING: a LOT of editing was required. Imagine what we had to cut out. Farrell nailing a lineout: https://x.com/premrugby/status/2055734778905731101?s=46See omnystudio.com/listener for privacy information.

Super Rugby is finishing with a flourish. With Nick W off with the tradies, Nick H and Nath chew the fat on the Tahs cleaning up in Suva and the Force chasing a dream... and do some number crunching to see what finals might look like. WARNING: a LOT of editing was required. Imagine what we had to cut out. Farrell nailing a lineout: https://x.com/premrugby/status/2055734778905731101?s=46See omnystudio.com/listener for privacy information.

Advances in immunotherapies for multiple sclerosis and related disorders have increased the risk of infections and raised important questions about vaccination efficacy. This episode reviews infection risks across treatment classes, emphasizes the importance of monitoring and patient education, and discusses optimal vaccine timing to preserve protective immune responses. In this episode, Aaron L. Berkowitz, MD, PhD, FAAN, speaks with Avindra Nath, MBBS, FAAN, coauthor of the article "Infection Risk and Vaccine Considerations in Multiple Sclerosis and Related Disorders" in the Continuum® April 2026 Multiple Sclerosis and Related Disorders issue. Dr. Berkowitz is a Continuum® Audio interviewer and a professor of neurology in the Department of Neurology at the University of California, San Francisco, in San Francisco, California. Dr. Nath is the chief of the Section of Infections of the Nervous System at the National Institute of Neurological Disorders and Stroke, National Institutes of Health, in Bethesda, Maryland Additional Resources Read the article: Infection Risk and Vaccine Considerations in Multiple Sclerosis and Related Disorders Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @AaronLBerkowitz Full episode transcript available here Dr Berkowitz: Over the last decades, there has been a revolution in the treatment of multiple sclerosis, neuromyelitis optica spectrum disorder, and other immune-mediated neurologic conditions with countless new, highly effective medications. However, with every new treatment comes new risks; and in the case of immunomodulatory therapy, many of those risks relate to infection. Today, I have the privilege of talking with an expert on this topic, Dr Avindra Nath, about the infectious risks of treatments for multiple sclerosis and other immune-mediated neurologic disorders.  Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast.  Dr Berkowitz: This is Dr Aaron Berkowitz, and today I'm interviewing Dr Avi Nath about his article on vaccine considerations and infection risk in multiple sclerosis and related disorders, which he coauthored with Dr Amit Bar-Or. This article appears in the April 2026 Continuum issue on multiple sclerosis. Welcome to the podcast, Dr Nath, and could you please introduce yourself to our audience?  Dr Nath: Thanks very much for inviting me to this podcast. I'm absolutely delighted to have the opportunity to discuss our areas of interest and expertise related to infections and vaccinations for MS patients. My area has been studying the infections of the nervous system since the beginning of the AIDS pandemic, and over the years and decades, we've developed expertise related to various types of CNS infections. That includes ones that are developing in individuals who have immune compromise due to a variety of different reasons. Dr Berkowitz: Fantastic. Well, glad to have the opportunity to speak with you today. When I was in medical school---and you were my attending, actually, we were just reminiscing, which we probably think was not that long ago, but is now over twenty years ago---there were just two medications for MS, right? Beta interferon and glatiramer acetate. And now we have over a dozen, and it's amazing to think of all the progress in these last two decades, as well as for related diseases like NMO. I don't think we even had the aquaporin-four biomarker, right, when I was working with you as a med student in the early 2000s. Dr Nath: And that certainly dates me a lot.  Dr Berkowitz: Both of us.  Dr Nath: Yeah.  Dr Berkowitz: Of course, with all these new treatments, these have been amazing advances for our patients, right? But these come with new treatment-related risks to monitor for with the immunomodulatory medications for MS and related disorders. And one of those most important risks is that of infection. So, your article reviews the potential infectious complications of medications used to treat MS, NMO, etc, and also covers considerations related to thinking about vaccines in this patient population. So, as the MS treatment landscape grows, I can say as a general neurologist, keeping up with all these medications and what to screen for and what to worry about and when to vaccinate just becomes more challenging every year. And your article has so many helpful tables, some organized by medicine, some organized by- sorry, medication, some organized by infection, some by vaccines. So, this is gonna be a great resource for our providers to print out and tape up in their clinic rooms. We won't be able to get into all the depth and detail that you have in this article today, but I do want to focus on some of the key points here related to the common medications we use for MS and which infections to think about and which vaccine considerations we might need to keep in mind for these medications. But before we delve into the drugs, I just wanna ask you more broadly, you talk in the article about the challenge of patients with immune-mediated diseases who are on immunomodulatory therapy being at risk for both flares of their disease and for infections; and these infections can present somewhat atypically, right, in immunomodulated hosts, to maybe coin a term you can correct me on, because they can't mount the full inflammatory response. So how do you approach new symptoms in patients on these immunomodulatory medicines as far as distinguishing disease flare from a treatment-related infection?  Dr Nath: So, I have to say that although a lot of new treatments have come along for MS, and they've really, you know, improved the outcome tremendously and there are so many different options, it has also kept people like me relevant because they cause a lot of various types of infections, and so keeps me in business all the same. But just as you mentioned, there's so many of them, even I have difficulty keeping track of what does what. So, you do need to be able to refer back to published literature, and the tables, I hope, will be quite useful in that regard. You're absolutely right, and you can get new infections, you can get reactivation of existing infections, and you can get atypical presentations of various types of infections that you may not normally think of. So that presents multiple challenges to the treating physician. The other interesting thing about MS is, just as you mentioned, that you already have CNS lesions to begin with. Now, on top of it, you have an infection, so now how to sort out what is the existing disease and what is the infection, it can again become challenging. But one thing is for sure: all these infections are caused by an organism. So, what you really need to do is, the underlying diagnostic is to demonstrate the presence of the organism. Whether you demonstrate it depending on the infection in the spinal fluid or in the brain or, you know, some peripheral organ system, that is going to be key to making the diagnosis. So, all your clinical acumen is good, but that alone may not be sufficient. Dr Berkowitz: Very good. So, when you see a, a patient now who has a new neurologic symptom in the context of an immune-mediated disease who's on immunomodulatory therapy, what goes through your mind? Are you thinking this disease and this drug, and sort of what are the infections, and does the syndrome match? Or are you thinking, you know, you can't always rely on the imaging to distinguish between, say, a flare of an MS and PML because white matter lesions could look similar? How do you sort of approach this scenario when it comes up?  Dr Nath: So, you're right. You have to keep an open mind so that even though you know some infections are more likely to occur with certain types of medications, that doesn't mean that others cannot occur. So, I think when you first see the patient, you should not jump to conclusions, but rather have an open mind. But yes, for example, your patient is on natalizumab, the chances of PML are going to be high. It's a very interesting drug. It does not cause immune compromise in the periphery, but what it's doing is preventing these cells from getting into the brain. So, because then it's acting at the blood-brain barrier. So that means that organisms that are already present in the brain have an opportunity to get reactivated. Turns out you don't have a lot of organisms in the brain, except JC virus seems to be one of them that does somehow, in some individuals, manage to reside out there. And so that can get reactivated. It can get reactivated in the periphery and then enter the brain, too. So, where the very specific mutations have to occur in that virus in order to take residence in the brain. That would be a suspicion that you might have, and MRI can be useful in, again, helping you think about that possibility. If you have typical lesions involving the U fibers, they're demyelinating, usually you do not have much edema around them because patient is immune compromised, but certainly within the brain in these individuals. And so, then you need to demonstrate the organism. The demonstration of the organism should be in the spinal fluid and not in the blood because in the virus, it can-- is reservoir in the kidneys and in the lymph nodes, and periodically it'll shed into the blood. Detection of the organism in the blood can be a false positive, but in the spinal fluid, it shouldn't be there unless you have an infection. Or if you cause a traumatic tap, I guess, if a patient is viremic, that's a possibility, but those are extremely rare. So at least for PML, that's the way that you would diagnose it. Now, you can develop, for example, if an individual is on fingolimod, you can get a wide variety of infections. Here it's a totally different type of mechanism of action. Here the cells are trapped within the lymph nodes, so that means now your entire periphery is immune compromised, right?  So here you can get viral infections, bacterial infections, fungal infections. So here, if a patient presents with new neurological symptoms, you have to have a really open mind for all these possibilities. Now, let's say a patient was on dimethyl fumarate, and dimethyl fumarate causes neutropenia early on. So here you have to worry about an individual developing bacterial infections, so latent tuberculosis or bacterial meningitis can occur in these individuals. That's something to keep in mind. It's not that other infections cannot occur with dimethyl fumarate, you can see PML and other things too, but the chances of bacterial infections are greater. So, you got to make sure that you draw all the cultures for that purpose. Similarly, if you're on a complement inhibitor, like a C5 inhibitor or the thing that I could use in NMO, there are the chances of meningococcal meningitis. So, these patients, you need to prevaccinate them before you start these kinds of treatments and look for that possibility. When you suspect bacterial infections, particularly acute bacterial meningitis, there time is of essence. Also, in some of the acute viral infections, for example---herpes encephalitis is another one---you have to be so careful, and if you suspect any of them, even if they're with possibly atypical manifestations, you treat first and then diagnose later, and draw all your cultures, whatever you need to, and just treat them. And these infections can also cause cerebral edema, so one has to be careful about doing spinal taps in these individuals. You want some kind of neuroimaging before you do them. In the days when we didn't have neuroimaging, we used to say, "Okay, if your patient has focal neurological signs or is comatose, you don't do it." But these days, you can get imaging very quickly and very easily. All the-- Because of our stroke management, we've learned how to do them so quickly. So, I think there's little excuse not to do imaging and prevent herniation from occurring.  Dr Berkowitz: That's very helpful. So, using the information we know about the drug, and we're going to rapid-fire review some of that in a bit to know what infections the patient is susceptible to, but acknowledging that any patient can get any infection, right? Whether they're on particular medications or not. And then if you're not sure, based on the neuroimaging, which as you said, is helpful, but not always helpful in distinguishing between infections and flares or, as you said, in the case of meningitis, encephalitis, early on at least, especially in immunocompromised or immunomodulated, quote unquote, patient might not see the typical imaging. So really, when safe, getting CSF or cultures, PCRs, and other infectious studies too is really gonna be the definitive diagnostic maneuver here. Is that fair summary across the board?  Dr Nath: I think you said that absolutely right. And you summarized that correctly. And, you know, thing about infection, a lot of neurological diseases are, you know, diagnosed by clinical acumen, like your Parkinson's and Alzheimer's and others. Think about infections is caused by an organism, demonstrate the organism, right? That should be your goal. It doesn't mean that clinical acumen is not important, but here you have an opportunity to demonstrate the organism, so you should depend upon that.  Dr Berkowitz: Okay. Well, you gave us a nice segue by talking about some of the infections to worry about with some of the medications. So what I'd like to do now for the sort of second half of our interview here is to go through some of the more common medications used for MS, and if we have time, for NMO, and just sort of go kind of rapid fire here, and for each medication, if you can tell us the kind of top infectious concerns and whether when to consider them or what screening needs to take place before or during administration of the medication, and then any vaccine considerations we should be aware of. Some of these will obviously be quite short depending on the medicine. So, going back to the two medications I alluded to earlier that were the only ones in play when you and I last saw each other on the wards when I was a medical student, beta interferon, glatiramer acetate, any infections or vaccine considerations with these medications?  Dr Nath: No, I think they're probably your safest medications now as far as immunomodulatory therapies are concerned. These two, and IVIG, if you ever use them, are probably the safest, do not require any vaccine considerations, per se. Dr Berkowitz: Perfect. Okay. So, moving on to fingolimod and others in the sphingosine-one phosphate receptor modulator family, what are the infectious considerations? Any prescreening or vaccination considerations?  Dr Nath: I think all your patients should be prescreened for antibodies to JC virus, because there is a risk for PML, and those who are positive should be closely monitored. So, it's not an absolute contraindication for using these medications, but they just require closer monitoring. With this class of drugs, PML is of consideration. Also, these varicella-zoster virus infection, yeah, with that you can develop zoster encephalitis or myelitis. It can present with motor symptoms as well, which can be atypical. You don't usually see them otherwise in immune-competent individuals. So, varicella-zoster, sometimes you can develop encephalitis, also vasculitis with varicella-zoster, so one has to be careful. So, getting the shingles vaccine can be actually very helpful to prevent these things. And then some patients can even develop herpes simplex encephalitis also, and that can be extremely atypical. So, they don't- they can involve the basal ganglia, can involve the brain stem and cerebellum. So again, your index of suspicion should be very high. Interestingly, although HSV encephalitis has been associated with NMDA receptor encephalitis, those reports of NMDA receptor encephalitis have not been published yet with NMS patients. Not sure why, maybe they just have been missed. But that doesn't seem to be a major concern. And then there are a whole host of other infections that can occur with this class of drugs, and that can include toxo; fungal infections, particularly crypto. There's a case report of histoplasmosis; hepatitis virus, particularly hepatitis C; and then the poxvirus is a good example. You can get molluscum contagiosum; warts with papillomavirus; you can get atypical mycobacteria; and even Kaposi sarcoma, which is HHV8. So, there's a huge variety of infections with the sphingosine one phosphate receptor modulators.  Dr Berkowitz: And any- aside from screening for JC virus before initiating these, any- and then continuing to monitor for JC antibody index, any other considerations as far as labs to send, monitoring before or on the drug or vaccine considerations for patients on fingolimod and the others in this category, siponimod, etcetera?  Dr Nath: Yeah, there are a lot of things to consider. All the details are really available in the chapter if you look at them. But briefly, all the things that one could potentially vaccinate patients for, all these infections I mentioned, one should do so. The timing is critical so that if you can do it before treatment, I think, before starting treatment, that is absolutely important. And you got to give them at least, you know, two to three weeks for these vaccines to take effect before starting your medication. If your patient already arrives on a medication, then you got to play this game of you know, before the next dose, give them again two to three weeks before the next dose and start vaccinating them and get all the vaccines in. Broadly, about the things to worry about the vaccines are you have live vaccines, and you've got the inactivated vaccines or the subunit vaccines. You have to be careful with live vaccines, because if your patient is immunocompromised, that virus can sometimes itself cause harm. For example, you know, yellow fever is one, and there you can develop encephalitis from it. Measles, mumps, rubella, these are all live vaccines. Now, the good thing is that a lot of us have been immunized very early in childhood, but that may not be the case any longer. And so, these things, one has to be very careful with when you're giving live vaccines, that we want to avoid them as much as possible, and individuals are gonna be immune-compromised. But all the others, meningococcus, for example, you should- the HPV vaccines, the varicella zoster vaccines, all these things, you've got to pre-vaccinate and make sure that they have an antibody response to them before starting immunocompromising therapy. Dr Berkowitz: Perfect. Okay, moving on to some of the other orals. What infectious and/or vaccine considerations do we have with teriflunomide?  Dr Nath: Okay, yeah. Teriflunomide is a very interesting drug. It's relatively safe. There is concern about the possibility of varicella zoster infection, people have reported that, and also tuberculosis. But PML is extremely rare, if not at all, and we haven't seen herpes encephalitis quite yet.  Dr Berkowitz: Got it. How about dimethyl fumarate? Dr Nath: Yeah. So dimethyl fumarate is... as I mentioned earlier, it's interesting because it causes this neutropenia. It's transient, but it occurs early on, and these patients can be at risk of PML, although small. They can develop varicella zoster virus infection, herpes encephalitis, and also fungal infections. For example, cryptococcal infection has been reported with dimethyl fumarate. Dr Berkowitz: Okay. We've spoken a bit about natalizumab and PML, and you have extensive information on this in your article, and I'll defer the reader to that. But for natalizumab, what are the key points every neurologist should know about natalizumab and PML as far as from the practical perspective, screening, frequency of screening, when to worry, when to not use natalizumab at all in the first place based on what you find in your screening for JC virus? What are the key points every neurologist should know?  Dr Nath: Uh, yes. You bring up an important point, and that is all patients should be monitored for JC virus. If they're JC virus-negative, so that's your most ideal patient to go on natalizumab, but that doesn't mean they cannot get infected with the virus. In fact, there's an interesting study claiming that, you know, patients, when they get these infusions, they're all sitting in the same room getting infused. Some have JC virus, some don't have JC virus, and so there's the potential that we may be aiding the transmission here in some way or another. The virus is an interesting one. It comes out in urine, and then it's spread through oral contamination, gets into the tonsils, and then spreads from there to your marrow and resides in the kidney and the marrow, as well as the lymph nodes, forever. So, you, you have to monitor these patients to see that during the course, even if they're negative, they could turn out positive. So, every six months or a year, an antibody test should be done on all patients irrespective. If a patient already has antibodies, that's not an absolute contraindication. It just means you've got to monitor them closely for development of new symptoms, and if, whenever there are new symptoms, don't just assume this is due to MS, but just make sure the MRI is done with and without contrast. The- and if there's still a suspicion, that you do a CSF evaluation for JC virus. Just detecting, looking for JC virus in the blood, a rising titer is another thing that can help you. And so, the titer is also important. And the reason you have rising titers is it means that there's an infection that's already occurred in the brain, and the immune system is reacting to that infection by increasing titers. But that alone is not sufficient to make the diagnosis. You still- that gives you an index of suspicion. You've got to then do the MRI and the spinal tap to, you know, be absolutely certain. So, each patient is a little bit different, so the way you monitor them is going to depend on where they are. You know, if they've had prior immunomodulatory therapy before starting natalizumab, or if they're on natalizumab for more than two years, then the chances of PML are much greater, so you may want to monitor them more closely. Uh, they never had any prior immunomodulatory therapy, you're just starting natalizumab, maybe once a year is sufficient. So, I think you've got to tailor it depending on what your risks are for each patient. Dr Berkowitz: Perfect. That's very helpful. And again, you write extensively about PML and natalizumab and PML considerations in your article. So, for a more detailed and in-depth discussion of what we just discussed, definitely hope readers will take a look at your article. Okay. Last but not least---certainly not least, 'cause we're using these probably, it seems, the most commonly in many places I've worked---rituximab, ocrelizumab are B-cell therapies for MS. What are some of the infectious and vaccine considerations related to these infusion medications?  Dr Nath: So, there's concern for PML with anti-B-cell therapies also, maybe not to the same degree as natalizumab, but the same principles should be applied. A lot of people think that these are relatively safe. I don't think so. I think we see enough number of patients on B-cell therapies with PML. So, I would use the same caution because these infections are... you know, can be fatal. So, one should be very careful, even with anti-B-cell therapies. And just with natalizumab, you also have the risk of VZV infection causing shingles. HSV1 has been reported, but there's another interesting complication that has been reported with anti-B-cell therapies, and that is severe West Nile encephalitis. And as mosquitoes-borne diseases are getting more and more prevalent, and we're seeing West Nile cases erupting every summer, I think one's got to be, you know, very cognizant of the fact that this can occur. These patients should take precautions to prevent mosquito bites from occurring and not expose themselves to areas where they could be at risk for it. Unfortunately, there is no vaccine for it and no specific treatment for West Nile. So, all one can do is use prevention strategies for mosquito bites.  Dr Berkowitz: Yeah, I'm glad you mentioned that. I think the only really truly severe neuroinvasive cases I've seen of West Nile virus have indeed been in patients who were being treated with B-cell therapy. Not, if I'm remembering correctly, for immune-mediated disease, but for a lymphoma, so probably other confounding factors there. But yeah, it's a disease we learn about and think about, but I've only seen the most severe cases in patients who had abnormal immune systems, so I'm glad you flagged that. This has been a very helpful discussion, and I've learned a lot from you. I learned a lot from your article, just as I did when you were my attending some 20-something years ago on the wards when I was a medical student. So, it's good to continue learning from you through your writing and research, and today from getting to talk to you again. I encourage our readers to read your article and to bookmark those tables for when these considerations come up for your patients on these immunomodulatory therapies and you're wondering which infections to worry about and how to manage vaccines in this patient population. So again, today I've been interviewing Dr. Avi Nath about his article on vaccine considerations and infection risk in multiple sclerosis and related disorders, which he wrote with Dr. Amit Bar-Or. This article appears in the April 2026 Continuum issue on multiple sclerosis. Be sure to check out Continuum Audio episodes from this and other issues, and thank you again to our listeners for joining today.  Dr Nath: Thank you so much, Aaron, for that wonderful interview, and I'm extremely proud of all your accomplishments over the last 20 years. You've done an amazing job, and it was such a pleasure to see you and to be able to do this interview with you. Thank you again.  Dr Berkowitz: Thanks. That means a lot. I never would have imagined- we won't say 20, how many, but 20-something years ago as the medical student looking up to you and all your expertise on these infections and all of your research that led to so much of our understanding on these, that I would find myself interviewing you two decades later. So, for all the students listening, you never know where you'll end up, but I appreciate your very kind words.  Dr Nath: That's what we hope for all our students. Thank you so much.  Dr Berkowitz: Thanks again.  Dr Monteith: This is Dr. Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Boa terça, angulers! Abrimos o #332 comentando o encontro entre Lula e Trump nos EUA. Mais uma canetada da diplomacia brasileira! No segundo bloco, Alexandre de Moraes suspende aplicação da Lei da Dosimetria até que o STF analise a constitucionalidade. Ainda falamos de Ciro Nogueira, alvo da PF no caso Banco Master. Por fim, o caso Ypê: de risco sanitário à defesa acalorada por bolsonaristas. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Today we acknowledge a great man who took one for the team... Darcy Swain dropped the kick-off in Canberra. Nick H returns from holiday to chew the fat with Nath and Nick W, and discuss whether the Aussie sides can turn around a flat run of form. WARNING: A few naughty words said. When the lads come together, the language warning comes up. Something we should probably ponder about at some point.See omnystudio.com/listener for privacy information.

Today we acknowledge a great man who took one for the team... Darcy Swain dropped the kick-off in Canberra. Nick H returns from holiday to chew the fat with Nath and Nick W, and discuss whether the Aussie sides can turn around a flat run of form. WARNING: A few naughty words said. When the lads come together, the language warning comes up. Something we should probably ponder about at some point.See omnystudio.com/listener for privacy information.

Na nossa época, para ler notícias e afins era preciso ir até um local específico da sua rua e comprar artigos em papel. Que saudades! Nathália Pandeló puxa o papo nostálgico sobre o que (e como) líamos na infância e adolescência.Assine ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠a newsletter Imagina Só⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, de Nathália Pandeló⁠⁠⁠⁠⁠Newsletter Pós-Jovem⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Pós-Jovem nas redes: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ |⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠BlueSky⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Playlist⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"Episódios Essenciais"⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Canal do Whatsapp:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Acesso aos Bastidores⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Design: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Nayara Lara⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Trilha: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Peartree⁠⁠⁠

This week it's time for Pokémon: The First Movie. Rob is a lifelong is a lifelong Pokéfan while Nath and Dave are bemused onlookers ready to receive a heartwarming introduction to the world of collecting, training, and trying your best. Which is a shame because what they actually get is an existential nightmare dressed as a children's adventure. What does it mean to be alive? What is the purpose of existing? And what would you do if you have to fight yourself to the death? Join us as we find out!Let us know what you think of this episode by emailing us at redshirtcinemaclub@gmail.com and support us on Patreon at patreon.com/redshirtcinemaclub for access to two bonus episodes per month as well as our newsletter, The Civilian Observer. Hosted on Acast. See acast.com/privacy for more information.

A disgusting photo Tuck shop mum Nath’s mid life crisis Things that are embarrassing Text from dad @thebuckuppodcast @katelangbroek @nathvalvo Our money back guarantee is that you're going to feel better at the end of this podcast than you did at the beginningSee omnystudio.com/listener for privacy information.

Nosso centésimo episódio, gravado ao vivo no Teatro Carlos Gomes. Uma conversa sobre grana, endividamento crônico, status performático e a linguagem global da ostentação.O Calma Urgente é uma produção da Peri Produções Na apresentação, temos Alessandra Orofino, Gregório Duvivier, Bruno TorturraNa Produção, Carolina Forattini Igreja e Sabrina MacedoNa Pesquisa e Roteiro,  Luiza MiguezNa Captação, Edição e Mixagem, Vitor Bernardes  @vitor_bernardes_Ilustração, Anna Brandão  @annabrandinhaNa sonoplastia, Felipe CroccoNa Edição de Cortes, Julia LeiteNas Redes Sociais Gabi BigaNa gestão de comunidade, Marcela BrandesIdentidade visual, Pedro InoueConsultoria de Comunicação, Luna CostaEquipe Calma - No TeatroProdução, Nathália RibeiroDireção, Gustavo Rosa de MouraDiretor de Fotografia, Pedro UranoAssistência e Operação de Câmera, Tomás Camargo e Mariana DuránLogger, Pedro FreitasTécnicos de Som, Matheus TiengoOperador de som, Ton OliveiraTécnico de Iluminação, Pablo MirandaRoadie, Reynaldo ThomazMaquiagem e Cabelo, Natali AraújoTransporte, Felipe MonteiroAgradecimentos especiais ao Teatro Carlos Gomes e sua equipe.

Boa terça, angulers! No primeiro bloco do #331, comentamos a rejeição de Jorge Messias pelo Senado. Pela primeira vez na história, uma indicação para ministro do STF é vetada. Ainda nesse bloco, falamos da derrubada do veto do PL da Dosimetria pelo Congresso. Fim dos tempos. No segundo bloco, explicamos o Desenrola 2.0, novo programa do governo para combater o endividamento de parte da população. Por fim, Lobacabana! O que achamos do show da Shakira no Rio? Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

On the latest PlayStation Access Podcast, we're chatting all about the brilliant SAROS. Join us as Ash, Nath and Alex discuss what makes Housemarque's latest title so special - from the mind-blowing visuals and audio design, to the pulsating combat and mysterious world.PlayStation Access is the official YouTube channel of PlayStation UK - a vibrant, welcoming community celebrating all things PlayStation. Join us for gaming livestreams, list features and in-depth coverage on all your favourite games. Hosted on Acast. See acast.com/privacy for more information.

Boa terça, angulers! Angu #330 no ar e começando pelo atentado nos EUA durante encontro anual da presidência com jornalistas correspondentes. Aproveitamos para atualizar a situação da Guerra com Irã que segue sem acordo de paz e com navios sendo interceptados pelos EUA. No segundo bloco, o relatório da Organização Internacional do Trabalho que aponta os riscos psicossociais de jornadas excessivas, assédio, instabilidade. Ambientes profissionais prejudiciais aumentam riscos de doenças cardiovasculares e transtornos mentais. Por fim, a expectativa pro ShakiCabana e a evocação de uma latinidade feminina que une todas nós. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Neste episódio da segunda temporada do Brasil que Produz, conversamos com Nathália Martins, advogada que encontrou seu propósito na sucessão familiar da Fazenda Camparino. O tema central é o equilíbrio delicado entre o legado de seis gerações e a modernização da gestão financeira e de comunicação no melhoramento genético. Nathália detalha os desafios de implementar processos baseados em dados em um ambiente tradicional , o papel educativo das redes sociais para "furar a bolha" do agro e as estratégias para envolver as novas gerações. Um conteúdo essencial para produtores que buscam perenidade no negócio e eficiência na comercialização de genética. PARCEIROS DESTE EPISÓDIO Este episódio foi trazido até você pela Silveira Consultoria! A Silveira é uma consultoria especializada em gestão e inovação no agronegócio, oferecendo serviços como consultoria produtiva, coleta de dados e apoio à tomada de decisões. A empresa apoia produtores com soluções práticas para melhorar eficiência e resultados na pecuária, integrando tecnologia e conhecimento do setor. Silveira Consultoria: Inovação na pecuária por gerações. Site: https://silveirapecuaria.com.br/Instagram: https://www.instagram.com/silveira_consultoriaFacebook: https://www.facebook.com/SilveiraConsultoriaPecuariaMt/LinkedIn: https://www.linkedin.com/company/silveira-consultoria-pecuaria Este episódio também foi trazido até você pela Estância Bahia Leilões! Estância Bahia Leilões conecta pecuaristas a oportunidades de negócios seguros e rentáveis na compra e venda de gado, por meio de leilões presenciais, virtuais e plataformas digitais. A empresa oferece transparência, tecnologia e dados de mercado, facilitando decisões e gerando melhor valor para o rebanho dos produtores. Estância Bahia Leilões: Inovando a pecuária, inspirando gerações. Site: https://estanciabahia.com.br/Instagram: https://www.instagram.com/estanciabahiaoficial/Facebook: https://www.facebook.com/EstanciaBahiaLeiloes/YouTube: https://www.youtube.com/@eb.oficial Este episódio também foi trazido até você pela Inbra! A Inbra Nutrição Animal desenvolve soluções e aditivos nutricionais com tecnologia para melhorar a produção de proteína animal de forma saudável e sustentável. Seus produtos auxiliam pecuaristas a aumentar eficiência, desempenho e conversão alimentar, oferecendo inovação técnica e resultados comprovados no campo, em diferentes sistemas produtivos. Inbra: Tecnologia exclusiva, resultados que transformam. Site: https://www.inbra.ind.br/Instagram: https://www.instagram.com/inbranutri/LinkedIn: https://www.linkedin.com/company/inbraYouTube: https://www.youtube.com/@Inbra INTERAJA COM O BRASIL QUE PRODUZSite: https://www.brasilqueproduz.com.br/Instagram: https://www.instagram.com/brqueproduz/YouTube: https://www.youtube.com/@BRqueProduzCortes: https://www.youtube.com/@Cortes-BRqueProduzCanal do Telegram: https://t.me/agroresenhaCanal do WhatsApp: https://bit.ly/arp-zap-01 QUERO PATROCINAR A PRÓXIMA TEMPORADASe você deseja posicionar sua marca junto ao Brasil que Produz, envie um e-mail para contato@agroresenha.com.br FICHA TÉCNICAApresentação: Gabriel Martins e Paulo OzakiProdução: Agro ResenhaConvidado: Natália MartinsEdição: W. FilmesSee omnystudio.com/listener for privacy information.

It's time for Super Round... and this week has been super in more ways than one with the game suddenly having a lot more cash! Nick W and Nath chat Super Rugby, the Wallaroos, Sevens rugby and more. OptaRugby: https://www.optaprorugby.com/ WARNING: just one or two naughty words, this one is acceptable for the kids.See omnystudio.com/listener for privacy information.

Boa terça, angulers! Um Angu #329 curtinho (juro!) no feriado. Comentamos o projeto de lei enviado pelo Governo pelo fim da escala 6x1 e redução de jornada de trabalho. No segundo bloco, um micro angu com as atualizações do carnaval: cinco escolas do grupo especial do RJ já anunciaram seus enredos! Na semana passada, foi sorteada a ordem dos desfiles em 2027. Claro, deu tempo de falar de São Jorge. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Trell Runs A Train On Val, The Crisis At The Dragons Continues & Nath's Massaging Money Moves!The Political Electorate 13+ Jumpers are back on sale for one week only. Get yours here via: https://hellosport.shop/Neds. Whatever you bet on, Take it to the Neds Level. Visit: https://www.neds.com.au/4 Pines, a brewery born in Manly and enjoyed everywhere. Get their Japanese Lager available here: https://4pinesbeer.com.au/Magic Round Warm Up with 4 Pines at Landers Pocket Brisbane on Thursday May 14th. Get your tickets here - https://sevn.ly/xqSt0OCeGood Day Multivitamin & Day Lyte Electrolytes, it's the least you can do. Use code 'dribblers' for 10% off your order here: https://www.begoodhealth.com.au/Join The Good Day Goers Facebook Group here.The Dragons Stinky SituationThe Bye Round Boys Rip In & Tommy's HammyTommy's Hammy & The Manly Situation The Remaining GamesAFL ScandalEddie V DanaNath Making Comfy Business MovesDribbles & Super Coach Brought To You By Good Day Multi Hosted on Acast. See acast.com/privacy for more information.

Nath Kachoa Na Janau, ਨਾਥ ਕਛੂਅ ਨ ਜਾਨਉ (Sri Guru Granth Sahib Ang 710 Sabad 1905)

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Boa terça, angulers! Abrimos o #328 com a nova tentativa frustrada de acordo entre Irã e EUA e, agora, o plano de Trump de bloquear navios que estão pagando o “pedágio” ao Irã para cruzar o estreito de Ormuz. Além disso, comentamos a crise entre Trump e o Papa Leão XIV. No segundo bloco, um apanhado de assuntos na direção das eleições: avaliação do governo; estratégias para aumento de popularidade; Desenrola 2.0; demissão do presidente do INSS. Por fim, os pop-ups da semana: a prisão de Ramagem pelo ICE, nos EUA; a derrota de Orbán, na Hungria; e o Rio de Janeiro que segue sem decisão sobre a eleição para o mandato-tampão. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza

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Boa terça, angulers! Começamos o #327 anunciando o convidado do Angu ao vivo em São Paulo! Não dá nem pra acreditar! Depois, entramos nos assuntos da semana. Abrimos com a tentativa de cessar-fogo entre EUA e Irã, mediada pelo Paquistão, mas que já foi rejeitada por ambos. No segundo bloco, EUA de novo: a Casa Branca voltou a criticar o Pix e o julgamento, em Los Angeles, que condenou pela primeira vez, Meta e Google por vício em redes sociais. Por fim, as novas regras da Prefeitura do Rio para tráfego de ciclomotores, autopropelidos e bicicletas elétricas e o voo de Artemis II ao redor da Lua. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

A curious phenomenon emerges this week as we watch 1984's The Neverending Story.It's a favourite from Dave's childhood which Nath and Rob were convinced they'd never seen. The evidence in fact points to them both having watched the film previously and entirely forgotten what happens, which is unfortunately also true of this latest rewatch (something to do with a sad horse and a flying dog, the details are lost to us).Which is all to say that The Neverending Story has a strange energy - a tinge of Euro-weirdness, the half-logic of children elected heroes in the face of magical annihilation, and an episodic structure full of grotesque puppets and special effects. We love it! We've forgotten it. It makes us sad.Let us know what you think of this episode by emailing us at redshirtcinemaclub@gmail.com and support us on Patreon at patreon.com/redshirtcinemaclub for access to two bonus episodes per month as well as our newsletter, The Civilian Observer. Hosted on Acast. See acast.com/privacy for more information.

One hidden plumbing issue wastes energy, increases costs, and creates serious safety risks—yet it can take hours (or days) to track down.In our latest Off the Cuff episode, PHC News Editor Steve Smith sits down with Shashwat Nath, senior product manager at Watts Water Technologies, to discuss how Watts is addressing one of the most frustrating challenges plumbers face: crossflow. The company's new LFUSG-CS Under Sink Guardian point of use mixing valve is the industry's first point-of-use mixing valve engineered to simplify diagnosis and repair through visual indication and a replaceable strainer cartridge.Whether you're a contractor, engineer, or facility manager, this episode offers practical insight into reducing time, labor, and material waste associated with diagnosing and replacing fouled point-of-use mixing valves. 

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In this insightful podcast, Dr. Dwarika Nath Dhungel, a leading expert on Nepal's water resources and diplomacy, dives deep into the growing Nepal water crisis and its regional implications. From the current state of Nepal water resources to the increasing water scarcity in South Asia, this episode uncovers critical challenges affecting the nation's future. We explore Nepal's complex water diplomacy with India and China, examining river treaties, groundwater statistics, and the policies governing naturally flowing rivers. The discussion highlights how water management failures, lack of long-term planning, and geopolitical tensions are shaping Nepal's water future. Dr. Dhungel also explains the risks of water conflict in Asia, the untapped hydropower potential of Nepal, and the importance of sustainable environmental policy. With climate change accelerating water scarcity, Nepal faces urgent challenges in irrigation, river management, and policy execution. Most importantly, this podcast outlines what Nepal's new government must do to fix water resource problems—offering actionable insights on policy reform, strategic planning, and international cooperation. If you're interested in Nepal rivers, water politics, and the future of Himalayan water resources, this episode provides expert knowledge you don't want to miss. GET CONNECTED WITH Dr. Dwarika Nath Dhungel: Facebook - https://www.facebook.com/dwarika.dhungel/ LinkedIn - https://np.linkedin.com/in/dwarika-nath-dhungel-43a05435 Google Scholar - https://scholar.google.com/citations?user=vn8ONA0AAAAJ&hl=en  

Boa terça, angulers! Voltamos de férias! Acabou a farra e já abrimos o #326 com adio de Janeiro sem Governo. Cláudio Castro, na eminência de ser cassado pro TSE, renunciou e está inelegível por oito anos. O Estado do Rio está com um governador interino, Ricardo Couto, presidente do TJ-RJ, e precisará convocar novas eleições para um mandato-tampão. No próximo dia 8, o STF decide se as eleições serão diretas ou indiretas. Mais uma vergonha na conta da política fluminense. No segundo bloco, comentamos a pesquisa PENSE, do IBGE, sobre a saúde dos estudantes brasileiros entre 13 e 17 anos. Um panorama profundo sobre os adolescentes e saúde mental, assédio, bullying, drogas, cuidados com saúde, educação sexual. Assunto importantíssimo. De olho nos combustíveis, hein? A alta do diesel estabilizou mas já aumentou mais de 20% desde o início da guerra. Sirva-se!Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Aussie comic Nath Valvo joined the team to help launch the Melbourne Comedy Festival in its 40th year anniversary! Nath dives into his time on "I'm a Celebrity..." in the jungle, and we recall memories from the lockdown days on Kennedy Molloy's drive show. Catch Mick in the Morning, with Roo, Titus & Rosie LIVE from 6-9am weekdays on 105.1 Triple M Melbourne or via the LiSTNR app. Mick In The Morning Instagram: https://www.instagram.com/molloySee omnystudio.com/listener for privacy information.

In this deep conversation with Biswo Nath Paudel, the Governor of Nepal Rastra Bank, we explore the future of Nepal's economy, artificial intelligence, and global financial trends. Dr. Paudel shares insights on AI in Nepal, why Nepal adopts technology later than other countries, and how the nation can build a competitive digital economy. The discussion covers Nepal's economic future, the impact of AI replacing jobs, and why developing nations must invest in technology, innovation, and curiosity-driven education. We also discuss how countries like China achieved rapid technology adoption, why Nepal should consider hosting data centers, and the importance of building industries that support long-term economic growth and GDP expansion. Another key topic is global finance—what happens if the US dollar weakens, and what economic strategies Nepal should adopt to stay resilient in a changing global economy. This podcast explores the intersection of AI, economic policy, technology adoption, and Nepal's development strategy. If Nepal wants to transform into a modern digital economy, investments in innovation, AI policy, and technology infrastructure will play a critical role. GET CONNECTED WITH Dr. Biswo Nath Paudel: Facebook - https://www.facebook.com/biswo.poudel.7 LinkedIn - https://np.linkedin.com/in/biswo-poudel-048aa94  

The Reds are on the rise... with two calls going their way in as many weeks. Nath, Nick H and one of our resident Queenslanders Andy chew the fat on the latest in Super Rugby, before you uniting to bully England for their rubbish Six Nations campaign. WARNING: rugby banter comes with swears. Whoopsy.See omnystudio.com/listener for privacy information.

Boa terça, angulers! Começamos o #325 comentando a expansão da guerra Irã x EUA e Israel, que já atinge quase todos os países do Oriente médio. Falamos também sobre os impactos da guerra para o meio ambiente e sobre o pacote de medidas anunciados pelo Governo para conter os impactos da guerra no preço do petróleo. No segundo bloco, volta a tensão entre Itamaraty e governo Trump. Assessor de Trump que viria visitar Bolsonaro teve o visto revogado. Por fim, o Oscar, os momentos e discursos mais marcante. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Today on the show, why do some of us age faster than others? Why do some of us grow old and die before our time while others seem to simply endure? And most of us have probably wondered at one point or another, which track am I on? Turns out it might be possible to predict the whole trajectory of an animal's life at a surprisingly young age, just by looking closely at subtle patterns of behavior. That's the conclusion of a new study from researchers at the Knight Initiative for Brain Resilience here at Wu Tsai Neuro, out March 12, 2026 in the journal Science. The study focused on the African turquoise killifish, a little fish that lives fast and dies young. This species has one of the shortest lifespans of any vertebrate, which makes it ideal for studying the entire arc of a life in the laboratory setting.The important point here is that even short-lived killifish are dealt different lots by the fates. Even when you control for genetics and the environment, some killifish only live a month or two, while others can live as long as a year. So the big question is, what drives this difference in longevity? To learn more, we're joined today by the study's two lead researchers, Wu Tsai Neurosciences Institute Postdoctoral Scholars, Claire Bedbrook and Ravi Nath, who performed the research in the labs of Anne Brunet and Karl Deisseroth here at Stanford.Learn MoreTo study aging, researchers give killifish the CRISPR treatment (Knight Initiative for Brain Resilience, 2023)Study pinpoints key mechanism of brain aging (Stanford Report, 2025)Killifish project explores the genetic foundation of longevity (Stanford Medicine 2015)Multi-tissue transcriptomic agingSend us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. We want to hear from your neurons! Email us at at neuronspodcast@stanford.edu Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

Boa terça, angulers! Abrimos o #324 com os novos acontecimentos no caso do Banco Master: a volta de Vorcaro para a prisão; a ordem de agressão ao jornalista Lauro Jardim; a morte do “Sicário”; a rede de influência, as trocas de mensagens com políticos do alto escalão; e onde aparecem as mulheres envolvidas nessa trama. No segundo bloco, os pop-ups da semana: o preço do petróleo em alta com a manutenção da Guerra entre Irã, EUA e Israel; os cinco réus do caso do estupro coletivo estão presos; o Oscar é nesse domingo! Flávia assistiu Hamnet - e amou! - e estamos na torcida pelo Brasil! Wagner, Kleber, O Agente Secreto, Adolpho, Gabriel. Vamos! Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

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Boa terça, angulers! Abrimos o #323 conversando com @LuyaraFranco, filha de Marielle Franco e diretora executiva do @institutomariellefranco. Falamos sobre a condenação dos mandantes do crime no STF, a sensação que fica para a família, os próximos passos do Instituto e o Festival Justiça por Marielle e Anderson que acontece domingo, dia 15/03, no Circo Voador (RJ). No segundo bloco, os casos recentes de violência sexual contra meninas e mulheres pelo Brasil: o caso da meninada 17 anos violentada por cinco homens, a idosa atacada por um motorista de ônibus, o caso da menina de 12 anos com um homem de 35 em MG. Tragédias, infelizmente, cotidianas num país em que reina a misoginia, a violência de gênero e a impunidade. Por fim, a tragédia em Juiz de Fora e Ubá com as fortes chuvas da semana passada; e a nova escalada de tensão e bombardeios entre Irã, EUA e Israel. Sirva-se! Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Boa terça, angulers! No #322, comentando o resultado do Carnaval 2026! Viradouro campeã, Beija-flor vice, o G6 das campeãs, as escolas mais penalizadas (justa ou injustamente?), as decepções, os troca-trocas já começando, as despedidas. O carnaval acabou mas o pós já está agitado! Por fim, os pop-ups da semana. Em especial, o julgamento no STF dos mandantes do assassinado de Marielle e Anderson começa hoje (24). Sirva-se!Apoie o Angu de Grilo no apoia.se: apoia.se/angudegrilo ou na Orelo: orelo.cc/angudegriloCortes do episódio em vídeo no @angudegrilo no Instagram e Tiktok! Siga, curta e compartilhe! Edição e mixagem: Tico Pro @ticopro_Redes sociais: Claudio Thorne @claudiothorneCortes em vídeo: Nathália Dias Souza @natdiassouza

Welcome back to one of our most special episodes of WYHA, in-which we're joined by the hilarious and lovely Nathan Valvo! Matt and Nathan hit it off quite quickly in the jungle and share some special memories together (some which never aired!), so we're chatting to Nathan to get his thoughts on the season, his experience, how he managed conflicts on the show and whether the edit was really fair towards Matt and the rest of the cast. We loved every second of our conversation with Nath and can't wait for you to hear more tomorrow xxSee omnystudio.com/listener for privacy information.