Podcasts about Monty

Hector, Ralph, Desi and Monty get together to discuss a mad few days...from Ireland's impressive exploits, Scotland's shockeroonie and then that AGM!They discuss the World Cup exploits and joy at watching those games. They look at Celtic involvement in internationals.They discuss the Manager Hiring, or lack of, updatesThey look at the THE AGM and the developing horror show that is Corporate Celtic Management. They wonder about the Boards end game here and ponder how this might all impact the team on the park.

Roger Saul created Mulberry - you know the one - from a £500 loan from his parents. By the 1990s, Mulberry was exporting to 30 countries, winning the Queen's Award for Export three times, and attracting fans like Kate Moss, Kate Winslet, and Bob Geldof.Roger, his wife Monty and their team at Mulberry, also went on to open the Michelin-starred Charlton House Hotel and restaurant as well as transforming Kilver Court in Somerset into a designer village. But when everything came to an end he could never have foreseen, Roger still didn't give up. Today he and Monty run Sharpham Park and Roger is now a walnut farmer. Roger shares how resilience, reinvention, and Somerset roots shaped his extraordinary journey. Perfect for listeners seeking entrepreneurial wisdom, creative courage, and stories of bold new beginnings.To learn more about Sharpham Park click here: To keep in touch (and I'd love that) - I'll send you my Next Chapter 3 pieces of Inspiration newsletter click here: https://www.elliebarkerwrites.com/To download your free heartwarming romance novella - Could We Just Do That Again? click here: https://www.elliebarkerwrites.com/ Hosted on Acast. See acast.com/privacy for more information.

Hector, Ralph, Desi and Monty get together to discuss a mad few days...from Ireland's impressive exploits, Scotland's shockeroonie and then that AGM!They discuss the World Cup exploits and joy at watching those games. They look at Celtic involvement in internationals.They discuss the Manager Hiring, or lack of, updatesThey look at the THE AGM and the developing horror show that is Corporate Celtic Management. They wonder about the Boards end game here and ponder how this might all impact the team on the park.

Twas the night before the Ashes, and so starts the Panesar-Smith the verbal bashes.We talk ticket prices and tours with a very special guest, all in anticipation for the Ashes first test.Follow all our socials: @justnotcrkpod

November 19th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline back from Las Vegas (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

November 18th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline live from Las Vegas at Circa(Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

Bestselling author, Jamie Day, discusses his suspenseful new release, THE LAKE ESCAPE. An annual friend's trip to the lake takes a dark turn when the woman one of them is dating disappears. Suspicion abounds and friendships are tested as each of the remaining friends wonders if the next lake tragedy will be their own. “A master storyteller with wit and style.” —William Landay, New York times bestselling author Listen in as we chat about the importance of collaboration, why hope matters, and find out how I became an instant fan of an awesome pup named Monty as well as Greta the Bookish Chiweenie! (Non book-related spoiler: Monty makes a couple of cameos in the video version of this interview on You Tube. Prepare to melt!) https://www.mariesutro.com/twisted-passages-podcast ABOUT THE AUTHOR: Jamie Day lives in one of those picture-perfect, coastal New England towns you see in the movies. And just like the movies, Jamie has two children and an adorable dog to fawn over. When not writing or reading, Jamie enjoys yoga, the ocean, cooking, and long walks on the beach with the dog, or the kids, or sometimes both.

Father Led Homes - Monty Joiner by Somerville St Church of Christ

durée : 00:59:44 - Tralala - par : Nathalie Piolé -

Bestselling author, Jamie Day, discusses his suspenseful new release, THE LAKE ESCAPE. An annual friend's trip to the lake takes a dark turn when the woman one of them is dating disappears. Suspicion abounds and friendships are tested as each of the remaining friends wonders if the next lake tragedy will be their own. “A master storyteller with wit and style.” —William Landay, New York times bestselling author Listen in as we chat about the importance of collaboration, why hope matters, and find out how I became an instant fan of an awesome pup named Monty as well as Greta the Bookish Chiweenie! (Non book-related spoiler: Monty makes a couple of cameos in the video version of this interview on You Tube. Prepare to melt!) https://www.mariesutro.com/twisted-passages-podcast ABOUT THE AUTHOR: Jamie Day lives in one of those picture-perfect, coastal New England towns you see in the movies. And just like the movies, Jamie has two children and an adorable dog to fawn over. When not writing or reading, Jamie enjoys yoga, the ocean, cooking, and long walks on the beach with the dog, or the kids, or sometimes both.

Clayton and Monty hit KLIF Notes...See omnystudio.com/listener for privacy information.

November 17th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline live from Las Vegas (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

Cal and Monty are joined by Alan Taylor as we talk all things Killie and preview Saturday's HUGE game against Motherwell.

Sermon Notes Date: 11/16/2025 Preacher: Monty Simao, pastor Series: Wisdom and Worship: Walking Through Psalms and Proverbs Key Text: Proverbs 28:13 Description: When our sin feels too heavy to face, we all have places we run. We cover. We excuse. We delay. We bury what we hope will simply disappear in the dark. But concealed […]

Episode 582! It's that time of the month! It's NXT Update! James and Monty are here for all things NXT! We review Halloween Havoc and talk TNA! Plus lot's more! Enjoy!!

November 14th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

Debbie sits down with Michael Cox who writes about horses in Hong Kong and Japan. Michael attended a Monty's Special Training to learn what the renowned trainer knows about the direction of horse racing. Listen in on his provocative findings...Horsemanship Radio 291:Show Host: Debbie LoucksTitle Sponsor: HandsOn Gloves, All-In-One Shedding/Bathing/Grooming GlovesPhotos used with permissionLearn more about Good Horsemanship at Monty Roberts EQUUS Online University Monty's CalendarPlease follow Monty Roberts on FacebookFollow Monty Roberts on Twitter or on InstagramSee more at: MontyRoberts.comHear all the shows on the Horse Radio NetworkSupport the show

Debbie sits down with Michael Cox who writes about horses in Hong Kong and Japan. Michael attended a Monty's Special Training to learn what the renowned trainer knows about the direction of horse racing. Listen in on his provocative findings...Horsemanship Radio 291:Show Host: Debbie LoucksTitle Sponsor: HandsOn Gloves, All-In-One Shedding/Bathing/Grooming GlovesPhotos used with permissionLearn more about Good Horsemanship at Monty Roberts EQUUS Online University Monty's CalendarPlease follow Monty Roberts on FacebookFollow Monty Roberts on Twitter or on InstagramSee more at: MontyRoberts.comHear all the shows on the Horse Radio NetworkSupport the show

November 13th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

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(00:00-38:57) Oooh, I must be hittin' a growth spurt. Thursday Throwdown. Welcome back, Bob. Like a fortress. Fight Tiger (basketball). We're like five presidents just sittin' around. The Irish guy comes through, make a note. This planet's not gonna be around much longer. Doug, do you want Steve in Wildwood or Dan Janson? Let's hear from Steve first. Rene Knott got hit by a bus. No room at Algonquin. Doug, you think Wellington's hot? Bracketology in November. Half my sons. Tufts for seniors. The Polar Express and Rumpleminze Santa. Even bums get presents. Timestamps.(39:05-52:18) Showtune Thursday. Mizzou's National Championship path. Audio of Florida interim coach Billy Gonzales being asked if Lane Kiffin would be a good fit at Florida. Good non-answer. Why'd you send the money, Lix? Shoutout the listener who sent Jackson tickets for the Mizzou game. There's a shrub on the dais. Who has blonde shrubs? Infidelity by the wayside.(52:28-1:11:42) Great to be reunited with Robert Thomas. Robert's assessment of the Blues' slow start. What does the team need to do to get back to their winning ways? Monty's playlist. Missing Jake Neighbours. Getting over the Game 7 loss to the Jets last year. The Tkachuk boys starting a podcast. Big life changes off the ice.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Robert Thomas joins us for his long-awaited return to TMA. Robert talks about how the team has arrived to this spot and the mindset it will take to get back to winning ways. Robert also talks about the rock music that Monty was playing. Robert then discusses the injury situation with Neighbours, goaltending, and the outlook on the next few weeks. Finally, we talk about Robert's wedding over the offseason. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

– What are the Cardinals' catching plans?– NFL Quick hitters– How did this team comeback with an overly inflated sense of what they were? Plus, Monty believes it's about to turn around...Do you?– The Junk Drawer: BK serves his punishment, eating a butter, mayo, onion sandwich.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Monty Franklin joins Jonesy & Amanda for a hilarious chat!See omnystudio.com/listener for privacy information.

November 12th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

November 11th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

  It's a full hour of Monty's random thoughts and bits of genius! Listener questions answered, and an update on the new Galactic Cowboys album. Plus…What's On TV?

This week, Monty tells us the 'desperate times call for desperate measures' situation her partner Sam recently found himself in that leaves Mel horrified. There's also some sweet young love at the 7/11, bad bedtimes, and a copy of Frank Sinatra's rider has us guessing what would be on each other's. Enjoy! Fancy supporting us on Patreon? Find out more here. Follow us and get in touch on Instagram here. Follow us on Facebook here.See omnystudio.com/listener for privacy information.

November 10th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

Monty Makes A Temperature Confession To DJ Ringgenberg and Matt Bermingham. The Crew Also Discuss Ham's War With Parking Attendant. 11-10-2025 Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon Music See omnystudio.com/listener for privacy information.

Sermon Notes Date: 11/09/2025 Preacher: Monty Simao, pastor Series: Wisdom and Worship: Walking Through Psalms and Proverbs Key Text: Psalm 62 Description: When life feels like it's slipping out from under us… we all run somewhere. To people. To accomplishments. To distraction. To whatever promises to hold us up when we feel like we're falling. […]

HELL, GOD, & GRACE. Not a popular topic but vital regardless. Monty & Roger's conversation delves into the themes of eternal suffering and the choices that lead to one's fate in the afterlife. The speaker emphasizes the stark reality of Hell compared to earthly struggles and discusses the concept of pride in relation to disobedience to God. The dialogue encourages listeners to consider their choices and the loving offer of salvation from God. Closing Song: The Goodness of God performed by Rhett Walker. ` #recovery #alcoholic #twelvesteps #wedorecover #addiction

To support this ministry and help us continue to reach people all around our region, click here: http://bethel.ag/give/Stay Connected Website: www.bethel.ag Bethel Church Facebook: www.facebook.com/bethelchurch605/ Bethel Church Instagram: www.instagram.com/bethelchurch605/

Episode 581! It's WWE Crown Jewell! James, Jaxie, Monty and Gina are here for all things WWE! We have RAW and Smackdown notes the it's Saturday Night's Main Event! Plus lot's more! Enjoy!!

November 7th, 2025 Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

November 7th, 2025 Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

November 7th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

November 6th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

(00:00) - Doug's in the Hamptons for his son's wedding. Charlie Marlow will come in today around 9 and we love that Chuck Marlow. Martin tells some great Charlie Marlow origin stories. Producer Joe. Martin's memory can get a little bit wonky. Doug and Martin MC'd an event last night. This event turned into a little bit of a Rams settlement debate. (22:00) - Blues got the win last night. Strong outing from Hofer. Jordan Kyrou a healthy scratch last night. Monty's comments about the healthy scratch. Harrison's Brother Master claims he changed his bet following the Kyrou scratch. Joey and Kerbs broke it down last night. (44:00) - Brand New Key. Brent Key at Georgia Tech with an outstanding clip of his allegiance to GT amid all the coaching rumors. The fellas break it down and compare it across College Football. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Start your weekend right with TGIF, hosted by Charlie Pickering. This show features special guests including TGIF with Monty Franklin, Bev Killick and Nicolette Minster.

(00:00) - Pat Benatar. Binnington and the stolen puck situation. Ovi's response. The TNT crew was entertained by Binner's antics. Texters are simply not happy. What will the response be tonight following the Sabres game? Thursday Night Football. (12:00) - Kerbs and Joey were critical of the goaltending efforts as of late. Martin goes through some of the numbers, and they are not good. Monty's comments were very telling last night. Would you bet on Buffalo tonight against the note? People sending in pictures of their wife. Tim's hotel situation in Columbia. We love the Colonel. College Sports coverage. (36:00) - Cat Daddy. Jackson dancing. Josh Pate's take on Mizzou vs. Texas A&M this weekend. Could Mizzou truly pull the upset this weekend. Jackson wants it bad. Looking at the Penn State schedule next year compared to Missouri See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Monty Pal and Dr. Pauline Funchain discuss the latest efforts to diagnose, prevent, and treat the series of immune-related adverse events that have emerged in the era of immunotherapy. TRANSCRIPT Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I am Monty Pal, a medical oncologist, professor and vice chair of medical oncology at the City of Hope Comprehensive Cancer Center in Los Angeles, California. Now, it is probably no surprise to this audience that immunotherapy has transformed the treatment landscape for multiple cancer types. It remains a pillar of modern oncology. Having said that, I think we have all been baffled by certain toxicities that we run into in the clinic. Today, I am delighted to be joined by Dr Pauline Funchain to discuss some of the checkpoint inhibitor toxicities that people struggle with most. And we will also touch on some side effects of immunotherapy beyond checkpoint inhibitors: CAR-T cells, bispecifics, so on and so forth. Dr Funchain is a dear friend, and she is an associate professor and associate director of cancer research training and education at the Stanford Cancer Institute. She is co-director of the Immunotherapy Toxicity Program and the Skin Cancer Genomics Program at Stanford, where she also serves as associate program director of hematology and oncology fellowship. Dr. Funchain is also the co-founder of ASPIRE, and we are going to talk about that a little bit today, the Alliance for the Support and Prevention of Immune-Related Events. FYI for listeners, if you are interested in our disclosures, they are available at the transcript of this episode. Pauline, thanks so much for joining us today. Dr. Pauline Funchain: Monty, thank you for this invitation. It is always great to talk. Dr. Monty Pal: So, for the audience, Pauline and I know each other from my days as a fellow at City of Hope. She was a resident at Harbor UCLA and a stellar resident at that. It has just been amazing to sort of see your career grow and blossom and to witness all the cool things that you are doing. ASPIRE, in particular, sort of caught my eye. So again, for listeners, this is the Alliance for the Support and Prevention of Immune-Related Events. Can you tell us a little bit briefly about the genesis of that, how that came about? Dr. Pauline Funchain: So, there was a bunch of us who were really struggling, I mean, all of us have struggled with these immune-related adverse events, these irAEs. You know, they are new disease states, and even though they look like autoimmune diseases, they tend to need a whole lot more steroid than autoimmune diseases do and they do not totally present in the same way. And in fact, you know, Triple-M, or Triple-M overlap syndrome, is a completely new irAE, a new immune state that we have never had before the advent of checkpoint inhibitor. And so a Triple-M, for those of you who are not as familiar, that is the constellation of myocarditis, myositis, and myasthenia gravis, something that never occurs as a natural autoimmune disease. So we were starting to realize that there were some major differences with these irAEs and autoimmune diseases. We could not treat them the right way. We really needed to learn more about them. And a bunch of us who had interest in this said, "Look, we really need to be all in one space to talk about what we are doing," because all of our treatments were our own little homegrown brews, and we needed to really get together and understand how to treat these things, how to diagnose them, and then learn more about them. So, Dr. Alexa Meara from Ohio State, Dr. Kerry Reynolds from Mass Gen, we put together this research consortium, brought together all of our irAE friends, got our best subspecialists together in a research consortium, which is now only about a year and a half old. And we made this research consortium, the Alliance for Support of Prevention of Immune-Related Events, and we reached out to ASCO, and ASCO was so kind to grant us a [Alliance for Support and Prevention of Immune-Related adverse Events (ASPIRE)] Community of Practice. So we met for the first time as a Community of Practice at the ASCO Annual Meeting just this past June and really got an ASCO community together to really think about how to again, diagnose, prevent, treat irAEs. Dr Monty Pal: This is interesting to me. The ASCO Community of Practice phenomenon is something that I was not super familiar with. Can you explain to our listenership what is the ASCO Community of Practice model? If you have particular interests, how do you sort of get one started? Dr Pauline Funchain: Yeah, so ASCO has an entire page on their Community of Practice. There are multiple Community of Practice groups or COPs. There are ones for Supportive Oncology and Survivorship. There is Women in Oncology. There is a group for International Medical Graduates. And there is about, I think 10 or 12 now that have a physical presence at ASCO but also a virtual presence on the ASCO Community of Practice site. So, if you were interested in any one of these, and you can see them on the ASCO Communities of Practice sites, you would ask to become a member. Once granted membership, then there is a whole webpage of postings and conversations that people can have. You can get email digests of conversations that happen on the website, and then you can anchor it with in-person participation at the Annual Meeting. Dr Monty Pal: That is awesome, and I can think of so many different foci within oncology that really sort of deserve a Community of Practice. This definitely being one of them. You know, it strikes me as being so interesting. I mean, the checkpoint inhibitors have been around for a while now. I think when you and I were in training, gosh, back then, these were just a little bit of a pipe dream, right? But having said that, I would probably say that more than half of my kidney cancer practice is either on checkpoint inhibitors, and the vast majority have been on one at some point in their past, right? With that in mind, you know, we have all treated a lot of patients with these drugs. Why is it that we still struggle to manage the toxicities? And just to take that one step further, what are some of the toxicities that, perhaps through ASPIRE or through your experience, people struggle with the most? Dr Pauline Funchain: So, I think we are still struggling with these because again, they are new disease states, right? This is what we all experienced with COVID, a brand-new virus and a brand-new syndrome. We now have 20-plus of these as irAEs. And what we have realized about them is the immune activation that happens with these is so much more than what we have seen with autoimmune diseases. So for instance, if you have a Crohn's or ulcerative colitis, you will top out at 40 to 60 milligrams of prednisone if a Crohn's flare or ulcerative colitis flare happens. But for our severe IR colitises, you know, it is at least 1 mg per kg, often goes up to 2 mg per kg. We, in some cases, have done 1 gram pulses if we are worried that somebody is going to perforate. So that was sort of like the first 5 years of treating irAE, and then now in the sort of second 5 years of treating irAE, we have realized that that is a lot of immunosuppression, and we might be able to get away with less with the newer biologics that are on board. So, we are struggling to try to get the data for some of these irAEs that we knew, we have known for a while, but to try to get newer treatments that may immunosuppress less so that you may still be able to retain that tumor response. And in fact, some of the preclinical studies suggest that some of these biologics may actually synergize with the immunotherapy and actually make the immunotherapy more effective from a tumor perspective and calm down the irAE as sort of the bystander effect. So we are still trying to optimize those. Getting up trials in the space has been very difficult. That is one of the reasons for the genesis of ASPIRE because we realized we needed to band together to have a bigger voice in that realm. Then there are other things that are brand new. So we talked about Triple-M. So Triple-M, again, with Triple-M or any myocarditis or myasthenia, I mean, there is about a 50% chance of death from irAE based on the literature. I think we are getting better at recognizing this, and so at Stanford we have some data to say that if you serially follow troponin, that maybe your outcomes are better. You can potentially lower the percentage of cases that are fatal because you can catch them early. I mean, this is all preliminary data, but again, these are all things that are evolving, and we do not all have the right answer. I mean, even the serial troponin thing, I think, is pretty controversial. And in fact, at one of our quarterly Zoom meetings that we are doing in ASPIRE in December is going to sort of flush out that controversy about serial troponin measuring and what is the best thing to use? Would you use something like abatacept or would you use ruxolitinib? Which one is better? I think there is a lot of controversy still about these things. Dr Monty Pal: You have really piqued my curiosity here because you think about the cons of treating irAEs, right? And I worry exactly about what you had mentioned, right, which is, "Gosh, what is going on with this tumor in terms of immunosuppression?" But you think about some of the newer agents, you mentioned ruxolitinib, I have heard of dasatinib, for instance, in this setting. Frankly speaking, a lot of these, as you point out, are really thought of as being also anticancer drugs. So you have really got me thinking about the potential synergy between perhaps suppressing an irAE and augmenting antitumor activity, which I think is very interesting. Am I on the right track with that? Dr Pauline Funchain: I think so, but you will find that a lot of people will not even go there because they are worried about how much immunosuppression you are going to cause. I am at heart a geneticist, but I think an immunologist will happily tell you that the immune system is very complex. There are multiple pathways, and these drugs do not all target the same immune pathways. So if we understand a little bit more about the pathways we are targeting and pick apart the pathways that are really, really tumor relevant and the other pathways that are not tumor relevant, you may be able to piece together a better marriage of tumor response and irAE control. Dr Monty Pal: Kind of on this topic, and again, leaning on your background in genetics, where are we in terms of predicting these irAEs? I mean, you would think the holy grail would be picking out a snip or something of this for it, right, that could potentially identify that patient who is going to get Triple-M or, you know, at the very least a significant high-grade irAE event. Are we anywhere closer to that in 2025? Dr Pauline Funchain: There have been data published. There have been some big GWAS studies. All of the effect sizes are pretty small. So there are some prediction algorithms, but none of them are clinically useful. And I think when you look at the odds ratios, they will increase risk by maybe 20%. I think one of the things that we found in a very small series and supported anecdotally is something as easy as family history of autoimmune disease is probably more predictive at this point than any of those types of markers. I think we will get there, but we are not anywhere near where we would like to be. Things like TMB also, actually, there is some good data about higher TMB, higher risk of irAE too. Dr Monty Pal: Interesting. I see all this data coming through, IL-8 polymorphisms, etc. And I just wondered if any of that was ready for prime time. But I mean, this is a good message for the practicing clinician. Sounds like we are not quite there yet. And I could probably keep you on for another entire podcast to talk about this topic, but let us see if we can at least skim the surface. I never thought I would see the day when BiTEs and CAR-Ts were entering into my kidney cancer practice, but in fact, it is really become central to a lot of our clinical trials in RCC these days. I would be lying if I did not say that I was not struggling with the toxicities and so forth associated with these drugs. Can you give us a quick primer, maybe just good resources that people can go to for managing toxicity with BiTEs and with CAR and with some of these novel therapeutic modalities that we are using in the oncology clinics? Dr Pauline Funchain: I know there is a recently published toxicity manual for BiTEs in hematologic malignancies, I think it was in Blood. CAR-T is covered in many irAE guidelines. So ASCO guidelines actually has a CAR-T [cell therapy guideline], and I would be remiss not to point out that actually ASCO has a, I am a little biased, but a wonderful guideline on irAE that is actually being updated as we speak. We are hoping for publication next year. I find the format of that, there are many guidelines out there, actually. There is ASCO, SITC, ESMO has a guideline for irAE, but I find the formatting of the ASCO guideline to be much easier to flip through during clinic, just because of the visual format of the tables. But that is going to be updated next year. And with CAR-T, there is now multiple publications also in terms of guidelines. But what I will say about bispecifics and CAR-T, so they have very similar toxicities in terms of the cytokine release and also with the ICANS, so the neurotoxicity. But what we have been finding that is really interesting with BiTEs and CAR-T, and actually even with TIL, cytokine release is very similar to some of the IL-2 toxicities but not identical that we see with TIL treatment. But now we are starting to see overlap. So patients who have been treated with immunotherapy and then go on to get a bispecific or then go on to get TIL, so I have seen some colitises that have occurred after the fact. Some of the newer CAR-Ts without checkpoint have been causing some really interesting, probably not in a good way, but interesting biologically, colitises that are really refractory. So we are starting to see some overlap, and again, I think this field is just evolving constantly. Dr Monty Pal: Yeah, no, I almost think I need to go back to that fellowship that you and I did together 20 years ago and, you know, and see if I could repeat some coursework on CAR-T management.  You know, Pauline, I could probably keep you on the horn for hours, but this has just been terrific. Thank you so much for sharing all of your insights with us today on the ASCO Daily News Podcast. Dr Pauline Funchain: Thank you for the invitation. It was wonderful to talk about this, and it was wonderful to catch up a little bit, Monty. Dr Monty Pal: Same here, same here. And thanks to our listeners too. If you value the insights you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:      Dr. Monty Pal    @montypal   Dr. Pauline Funchain @FunchainMD Follow ASCO on social media:       @ASCO on Twitter      ASCO on Bluesky     ASCO on Facebook       ASCO on LinkedIn     Disclosures: Dr. Monty Pal:     Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview    Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical    Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis    Dr. Pauline Funchain: Consulting or Advisory Role: Merck, Replimune, Sanofi/Regeneron, Immunocore, Tempus Research Funding (Inst.): Pfizer, Bristol-Myers Squibb, IDEAYA Biosciences, Linnaeus Therapeutics Travel, Accommodations, Expenses: Merck

November 5th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

November 4th, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

Monty reveals the biggest gardening lessons he's learned during his career, including how to use colour and light in the garden throughout the year. Discover his love of visiting gardens for their stories and life, how important it is to connect with the natural world and the joy of creating something that connects people and plants. Recorded at Gardeners' World Live in June. Learn more about your ad choices. Visit podcastchoices.com/adchoices

November 3rd, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

October 31st, 2025 We gather up the brain trust of the Sweet Spot (Sean Bass & David Mino) & the Hardline (Corby Davidson, Bob Sturm & Dave Lane) led by Monty to give us birthdays, shoutouts, 'on this day in history' and any other nuggets to show you Why Today Doesn't Suck. Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

October 30th, 2025 Follow us on Facebook, Instagram and X Listen to past episodes on The Ticket’s Website And follow The Ticket Top 10 on Apple, Spotify or Amazon MusicSee omnystudio.com/listener for privacy information.

The final battle is coming, but first Monty and Von Arnim will try for spoiling attacks. Neither get far, thus it comes down to Operation Vulcan. Learn more about your ad choices. Visit megaphone.fm/adchoices