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80% of all autoimmune diseases occur in women, and no one can explain why. Cancer cells are always present in your body, but it's only when your T cells go into energy deficit that cancer starts overtaking the system. And here's what almost no one is talking about: the mitochondria in your immune cells are the reason MS, chronic fatigue, neurodegeneration, and even cancer progression happen when they happen. In this episode, I sit down with Dr. Anurag Singh, MD, PhD immunologist who spent 20 years studying mitochondria and screened 4000 compounds from pomegranates to discover one molecule that changes cellular aging. We break down immunometabolism, the emerging field linking immune health and metabolism, why your T regulatory cells are the CEOs of your immune system, how mitochondrial dysfunction in immune cells triggers autoimmune conditions, and why rejuvenating mitochondria can get your immune system in check to defeat cancer. We also cover NAD+ (and why NMN and NR supplements don't work the way people think), the creatine sweet spot for muscle quality (500mg-1g, not the 5g everyone's taking), why Parkinson's is linked to paraquat, a mitochondrial toxin used in fertilizers and dry cleaning and how AI is fast-tracking the discovery of next-generation molecules for neurodegeneration. This conversation completely shifted how I think about immune health, brain protection, and what's actually driving the diseases we fear most. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: Why 80% of Autoimmune Diseases Occur in Women 01:24 Why Dr. Anurag Became an Immunologist 03:19 Immunometabolism: The Link Between Immune Health and Metabolism 04:20 T Cells, B Cells, and the Thymus Gland 05:51 MS and Autoimmune Disease: The T Regulatory Cell Problem 11:32 Mitochondrial Dysfunction and Immune Exhaustion 18:45 Cancer Cells and T Cell Energy Deficit 24:10 Urolithin A: Screening 4000 Pomegranate Compounds 31:20 Mitophagy and Autophagy: Cellular Housekeeping 38:50 NAD+ vs NMN and NR Supplements: What Actually Works 43:15 Creatine Dosing: The 500mg-1g Sweet Spot for Muscle Quality 48:30 Gut-Brain Connection and Neurodegeneration 50:54 Parkinson's Disease and Paraquat: The Mitochondrial Toxin 53:25 AI in Drug Discovery and Next-Generation Molecules 55:38 Skincare and Mitochondrial Health: Collagen Synthesis _______ Thank you to our sponsors KetoneIQ: https://ketone.com/NEURO for 30% OFF Caraway: Carawayhome.com/neuro10 Jones Road Beauty: https://www.jonesroadbeauty.com - Use code NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices
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Unveiling Coinbase's "Everything Exchange" with Head of Consumer and Platform BD Mark Troianovski. In today's Markets Outlook, Coinbase Head of Consumer and Platform Business Development Mark Troianovski joins CoinDesk's Jennifer Sanasie to unveil the platform's massive expansion into 24/5 stock and ETF trading for US users. He breaks down the vision for an "everything exchange" that blends crypto, equities, and prediction markets. - Timecodes: 01:10 - Coinbase Launches Stock Trading to U.S. Customers02:40 - Coinbase's Partnership with Yahoo! Finance and Integration03:55 - Will AI Agents Trade Stocks and Crypto for You?05:14 - Competing with TradFi Exchanges and Coinbase's "Sweet Spot"07:21 - Is Coinbase the Next "Everything App" for Finance?s - This episode was hosted by Jennifer Sanasie.
472 - Is a Disney World Moderate Resort worth the upgrade? In this episode of the Disney Travel Secrets Podcast, #1 best-selling authors and Travel Agents Rob & Kerri Stuart break down everything you need to know about Walt Disney World's four Moderate Resorts — and why they might be the smartest move for your next Disney vacation. Let us help you plan your Disney Vacation - CLICK HERE From the cozy charm of Disney's Port Orleans French Quarter (Rob & Kerri's personal go-to) to the convention-style luxury of Disney's Coronado Springs Grand Destino Tower, the riverboat magic of Port Orleans Riverside, and the Disney Skyliner access at Caribbean Beach Resort — this episode covers it all. Rob & Kerri also share a hilarious personal story about how a septic system emergency led to a spontaneous overnight stay at French Quarter, why Coronado Springs is unmatched for dining and concierge perks, and the real dollar-for-dollar value of stepping up from a Value Resort to a Moderate. In this episode you'll learn: The key differences between Disney's Value, Moderate, and Deluxe Resorts Which Moderate Resort is best for families, couples, and convention travelers Why the Disney Skyliner changed everything for Caribbean Beach Resort The best pools, dining, and theming at each Moderate Resort Whether the ~$90/night price difference is actually worth it (spoiler: Rob & Kerri think so) Insider tips on mobility considerations, room sizes, and transportation options Why Port Orleans French Quarter is the smallest — and most beloved — resort on Disney property
Unveiling Coinbase's "Everything Exchange" with Head of Consumer and Platform BD Mark Troianovski. In today's Markets Outlook, Coinbase Head of Consumer and Platform Business Development Mark Troianovski joins CoinDesk's Jennifer Sanasie to unveil the platform's massive expansion into 24/5 stock and ETF trading for US users. He breaks down the vision for an "everything exchange" that blends crypto, equities, and prediction markets. - Timecodes: 01:10 - Coinbase Launches Stock Trading to U.S. Customers02:40 - Coinbase's Partnership with Yahoo! Finance and Integration03:55 - Will AI Agents Trade Stocks and Crypto for You?05:14 - Competing with TradFi Exchanges and Coinbase's "Sweet Spot"07:21 - Is Coinbase the Next "Everything App" for Finance?s - This episode was hosted by Jennifer Sanasie.
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Last week's 2026 Hotel Equities Leadership Conference in Las Vegas was a tremendous success! The annual event was filled with thought leadership, networking, and insights with the best and the brightest in the industry. Did you miss any of the panels, sessions, or key moments? Don't worry! The Suite Spot and Hotel Equities partnered together to bring you Hotel Equities Part 1, in the latest Suite Spot episode, which contains three exclusive interviews with some of the biggest names at Hotel Equities. Episode Transcript Our podcast is produced as an audio resource. Transcripts are generated using speech recognition software and human editing and may contain errors. Before republishing quotes, we ask that you reference the audio. Ryan Embree: Welcome to Suite Spot, where hoteliers check in, and we check out what's trending in hotel marketing. I'm your host, Ryan Embree. Hello everyone. Ryan Embree here from the Sweet Spot for a very special episode where we head out to Las Vegas, Nevada for the 2026 Hotel Equities Leadership Conference. There we had the opportunity to sit down with several key team members from the hotel equities team. In this episode, we talk to Greg Osteen, chief Development Officer, who talks about the strategic growth of hotel equities and where they see opportunity. Becky Ley with commercial and strategy tips and trends that she's seeing right now within the portfolio. And Maria Parla, who is focused on that Kala region, the Caribbean and Latin America, uh, region, which hotel equity has been growing is so excited about Can't Wait to Bring It all to you in these next three episodes in our special Hotel equity episodes, part One. Hello everyone. Welcome to another episode of the Sweet Spot. This is the host Ryan Embry here at the RA Resort and Casino Las Vegas at the 2026 Hotel Equities Leadership Conference. I'm here with Greg Osteen, chief Development Officer. Greg, thank you so much for joining me here at the conference. Greg O'Stean: Thank you for having me. Ryan Embree: We just talked about it, almost 800 or almost a thousand attendees about to file through here. We're right next to registration. Uh, this is your first Hotel Equities Leadership. Greg O'Stean: It is. Ryan Embree: What are you excited about? What do you hope to take away from these next couple days? Greg O'Stean: So, as you said, my first, I joined April of last year, so I just missed last year's conference. Very excited about this one. Very excited to talk about all the things that have happened in the last year. More importantly, talk about where we're going Sure. As we are transforming together and as we're changing, you know, what is a great company today and making it even better. So I'm excited about that. I'm excited about meeting all the folks who make it happen every day. Yeah. Because most of the people coming here today are the leaders from our hotels, from the properties. It shouldn't be a surprise to you there. At the headquarters where I work, there are no cash registers. Right. , we, we, we don't make any money at the headquarters. We spend money. Yeah. But, but the company lives and dies by what happens in the field. Yeah. And those people are here, and I'm excited about that. Ryan Embree: It's so cool. And there's something magical when you get those onsite property Yeah. People all together, because we're gonna talk about it here in a second, but, uh, you start to hear patterns, trends Yeah. Things bubbling up that, you know, you have properties all over the country. We do. But it could be a property, you know, that shares that struggle across the country. That's right. And then be able to discuss those issues and, and challenges that, uh, hospitality right now, you know, continues to phase, but also all the, all the great trends that are on the horizon. Greg O'Stean: A hundred percent. And we're growing across Canada and Latin America as well, but just in the US.
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Emerging market fixed income is off to another strong start in 2026, with scope for further upside as long as the dollar cooperates and cross-asset volatility remains low. Christian Lawrence, chief cross-asset strategist at Cooperative Rabobank, joins Damian Sassower, Bloomberg Intelligence's chief EM fixed income strategist, to discuss investor positioning, currency hedging and event risk. They discuss drivers of institutional demand, including yield differentials, terms of trade, artificial intelligence and geopolitical developments.
This episode tackles a classic Ben Hogan quote: “You only hit a straight ball by accident… so you'd better make it go one way or the other.” We break down what that really means, and whether trying to shape every shot is actually helping your game or quietly widening your dispersion. Using real launch monitor data, on-course experience, and some ball-flight physics, we explore why tighter shot patterns matter more than how the ball curves in the air. Thank you to our show sponsors Ultra Pouches and Cash App Ultra is the ultimate guilt-free pouch — delivering instant focus and mental clarity, without nicotine or caffeine. New customers can use code SWEETSPOT to get 15% off at https://takeultra.com/https://takeultra.com/ • Download Cash App Today by visiting this link #CashAppPod. Cash App is a financial services platform, not a bank. Banking services provided by Cash App's bank partner(s). Prepaid debit cards issued by Sutton Bank, Member FDIC. See terms and conditions at https://cash.app/legal/us/en-us/card-agreement. Cash App Green, overdraft coverage, borrow, cash back offers and promotions provided by Cash App, a Block, Inc. brand. Visit http://cash.app/legal/podcast for full disclosures. Learn more about your ad choices. Visit megaphone.fm/adchoices
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Grace & Grit Podcast: Helping Women Everywhere Live Happier, Healthier and More Fit Lives
Health transformation isn't discipline OR desire—it's both. Learn to find the sweet spot where structure and pleasure intersect for midlife women during perimenopause and menopause. Discover why women over 40 need both discipline and desire, how to honor pleasure while maintaining structure, and practical strategies for sustainable approaches incorporating both. Perfect for women ping-ponging between rigid rules and complete abandonment. Includes integration practices and both/and thinking frameworks. If you want to take this work deeper, grab my book The Consistency Code: A Midlife Woman's Guide to Deep Health and Happiness. ✨ It's the roadmap midlife women are using to lead themselves powerfully in the health arena and beyond. Available now at https://theconsistencycode.com
Your confidence is only as accurate as your self-assessment. In today's episode, Kevin and Alan challenge how most people think about self-worth and explain why being miscalibrated quietly leads to stalled growth, missed opportunities, and frustration. They break down a more grounded way to evaluate yourself using results, feedback, and consistency, so your confidence is built on something real.If you are serious about leveling up, this conversation will change how you measure progress. Listen now and close the gap between where you think you are and where you actually are._______________________Learn more about:Join us on April 11th for Next Level Live. This is where we take the principles from the podcast and turn them into a structured implementation. If you want real progress, pay attention. More details coming soon.Book Alan's Business Breakthrough Session. Your first 30-minute coaching call is FREE. Learn how to prioritize success and let your quality of life become the byproduct. - https://calendly.com/alanlazaros/30-minute-breakthrough-session_______________________NLU is not just a podcast; it's a gateway to a wealth of resources designed to help you achieve your goals and dreams. From our Next Level Dreamliner to our Group Coaching, we offer a variety of tools and communities to support your personal development journey.For more information, check out our website and socials using the links below.
For this week's Horror Bytes, Safe Room's indie horror showcase, Neil and Jay kick off February's theme of 9 to 5 Horror, chatting about Terminal Lucidity & The Sweet Spot! Safe Room is a Bloody Disgusting weekly horror video game podcast with new episodes every Monday and Thursday. For additional streaming services: Linktree. Feel free to follow the show and hosts on Twitter & Blusky: Safe Room's Twitter | Safe Room's BluSky | Neil | Jay | Horror Bytes |
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Do you know your maintenance calories and why they would change? Most ladies who lift don't, and it's the missing baseline for energy, hormone health, muscle growth, and sustainable fat loss. In this episode, I'm breaking down what maintenance calories are, realistic ranges for women who train, what determines yours, and how to use them throughout the year so you stop yo-yo dieting and start eating enough to perform and look your best. You'll learn: Why maintenance is your body's “sweet spot” (and why it's a range) How it supports fat loss phases without rebound What happens to maintenance as you get leaner How to calculate and strategically work up to yours If you want a physique that's strong, fueled, and maintainable, this is step one. When I say “Eat Enough”, eat at your maintenance calories is exactly what I mean. Book a Consultation with Jenny → Create Your Shape (Starts March 9): https://calendly.com/jennythenutritionist/consultation Work with Jenny the Nutritionist in Create Your Shape:https://jennythenutritionist.com/create-your-shape/Follow Jenny the Nutritionist on Instagram:@jennythenutritionist
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Henry talks with Dr David Roy about the state of education in Australia. Dr David Roy is a Lecturer and Researcher in Education and Creative Arts at the University of Newcastle. Prior to entering academia, he spent 17 years as a classroom teacher, experience that continues to shape his research, teaching, and community engagement.Dr Roy's work focuses on inclusion and equity in education, with particular expertise in disability, arts engagement, and education policy. He is committed to translating research into practice and works collaboratively with schools, systems, and policymakers across Australia. Engaging with representatives from across the political spectrum, he advocates for evidence-informed approaches that strengthen access, participation, and outcomes for children and young people with disability, particularly through the Arts.An accomplished author, Dr Roy has written 12 books and numerous peer-reviewed articles and professional publications. His work has been widely recognised. He was nominated for the 2006 Saltire/TES Scottish Education Publication of the Year and for the Educational Publishing Awards Australia Tertiary (Wholly Australian) Teaching and Learning – Blended Learning (2020), as well as the Drama Victoria Best New Australian Publication (2020). In 2013, he won the Best New Australian Publication for VCE Drama and/or VCE Theatre Studies. He was also named a ‘Most Influential Educator 2022 (Australia)' and received the 2022 University of Newcastle CHSF Leadership Award.His most recent publications include Teaching the Arts: Early Childhood and Primary (2025), published by Cambridge University Press, and The Inclusive Teacher (2025), published by Routledge.Audio production by Rob Kelly.
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In this conversation with Bizzie Gold, founder of Break Method and creator of brain pattern mapping technology, Karena explores how childhood experiences create predictable patterns that shape your relationships, career, and mental health—and how understanding your source belief pattern can help you break free from self-deception and build a healthier life.How do you rewire the brain patterns formed in childhood that still control your life today?Understanding your source belief pattern is the first step toward breaking free from self-deception and building the life you actually want.(02:05) Brain Pattern Mapping & Bypassing Your StoryHow Bizzie created a predictive algorithm with 98.3% accuracyUnderstanding childhood experiences as a "distortion filter"Helping people see their own blind spots(06:16) The Sweet Spot of Trauma That Makes Great EntrepreneursWhy childhood instability creates self-trust and self-efficacyDeveloping situational awareness to stay safe and how it translates to businessBeing able to "think five rings down" when others can't see what's comingAttracting chaotic people because you have too much empathyWhy workaholism is easier than intimate relationships for abandonment patterns(13:47) Enmeshment Patterns & The Right Side of the SpectrumThe struggle with self-trust and decision-makingWhy enmeshed patterns need to learn to disappoint peopleUnderstanding why some people can't say no(27:18) Self-Deception & Why Your Brain Lies to YouHow childhood patterns create self-deception mechanismsWhy Bizzie keeps giving chances to people with bad intentionsThe lesson: don't let empathy destroy your business from the inside(40:33) Growing Up with Psychiatric Illness & Finding Your DriveBizzie's experience with an unstable, abusive childhoodActivities and achievement as a distraction from chaos at homeWhy self-preservation instincts don't come naturally for some patterns(49:08) Self-Care for Workaholics & Pattern OppositionWhy self-care is actually mental health work for go-go-go peopleDoing things that make you feel accomplished in self-careFor avoidant patterns: the opposition is to just...
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To access your free evaluation from Par4Success, vist this link: https://par4success.com/sweetspot Chris Finn of PAR4Success unpacks what actually matters in golf fitness - and where most golfers go wrong. In this episode, we discuss: Research-driven insights on aging, mobility, strength, and power, including what truly correlates with clubhead speed. Overspeed training myths, why more volume often backfires, and how golfers should think about mobility vs. flexibility. Building a proper physical foundation is critical for hitting it farther and staying healthy. A practical, no-nonsense conversation designed to help golfers train smarter, avoid injury, and play better golf for longer. Thanks to our show sponsors Ridge, The Indoor Golf Shop, and Gemini Upgrade your everyday carry with Ridge Wallet 2.0 — the sleek, ultra-durable wallet that's 10% lighter, RFID-blocking, and built for life. With over 100,000 five-star reviews and 50+ styles (including NFL, MLB, and college team editions), it's the gift. Get up to 10% off using promo code SWEETSPOT at https://www.ridge.com/sweetspot — and make sure to tell them The Sweet Spot sent you • As we enter the winter season, many golfers will be looking to upgrade their indoor practice. I've been trusting The Indoor Golf Shop for years and recommending them to anyone who wants to improve their home setup. They offer all the top launch monitor brands, including SkyTrak, Uneekor, and Foresight, and regularly run sales. They also have everything you need for your indoor practice - hitting mats, golf nets, impact screens, and custom enclosures. If you're looking for a custom residential build to have the simulator of your dreams, their team can make that happen. They built mine! And their designers can also handle any kind of commercial facility where you're building from scratch or want to make an upgrade. To learn more, check out https://shopindoorgolf.com/ • Are you interested in effortlessly growing your bitcoin portfolio? The Gemini Credit Card earns you bitcoin back on every purchase. Use it like any credit card—buy lunch, gas, or your weekly groceries—and you'll earn up to 4% back instantly in bitcoin or one of over 50 other cryptos straight to your account. All that with no annual fee. It's the easiest way to start building your bitcoin stack. Go to gemini.com/card to learn more! Terms Apply. Learn more about your ad choices. Visit megaphone.fm/adchoices
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