Podcasts about osterhout

Know in detail about the new age cutting edge technology in the Functional Medicine that can help improve treatment of various problems especially Hashimoto's - Peptides and ExosomesAbout the Guest:Since 2004, Dr. Osterhout and his team at Vitality Healthcare have helped thousands of patients in Portage achieve natural health and wellness by addressing the causative factors of poor health, therefore creating opportunities for the body to heal.  Vitality Healthcare is a prominent natural health and wellness center in the Portage community specifically designed to serve your natural healthcare needs.Unlike conventional medicine, which focuses on attempting to treat disease once it occurs, Dr. Osterhout emphasizes improving your health in an effort to reduce the risk of pain and illness in the first place. Most people would rather be healthy and avoid illness if they could. This is one of the main reasons for the big surge in popularity at our natural health and wellness center in Portage.As a patient at Vitality Healthcare in Portage, we will personally tailor a wellness program specifically targeted to your wellness needs using the least invasive yet highly-effective techniques and services.Attend a free Health Solutions Seminar with Dr. Osterhout at our natural health and wellness center to learn more about:-Overcoming poor health by identifying, detoxifying, and healing root causes.-Decreasing stress-Avoiding common foods that actually destroy your health-Ensuring optimal health and healing-Easily get fit and maintain a healthy weightContact:Website- https://yourvitalityhc.com/Connect With Me -Instagram - https://www.instagram.com/anshulguptamd/Twitter - https://www.twitter.com/anshulguptamdFacebook - https://www.facebook.com/drguptafunctPinterest - https://www.pinterest.com/anshulguptamdTo Buy Good Quality Supplements Goto -https://functionalwellbeingshop.com/Work With Me -https://www.anshulguptamd.com/work-with-me/Take The Thyroid Quiz & Evaluate Your Thyroid Health -https://www.anshulguptamd.com/thyroid-quiz/About Dr.Anshul Gupta MD -Dr. Anshul Gupta Md Is a Board-certified Family Medicine Physician, With Advanced Certification In Functional Medicine, Peptide Therapy, And Also Fellowship training in Integrative Medicine. He Has Worked At The Prestigious Cleveland Clinic Department Of Functional Medicine As Staff Physician Alongside Dr. Mark Hyman. He Believes In Empowering His Patients To Take Control Of Their Health And Partners With Them In Their Healing Journey.He Now Specializes As A Thyroid Functional Medicine Doctor, And Help People Reverse Their Unresolved Symptoms Of Thyroid Dysfunction.

I am sharing with you my episode with Bobby Osterhout from 2018. Enjoy!

On this episode of The Creepy Side of NEPA we talk with Richard Miller, executive director of the Osterhout Free Library in Wilkes-Barre PA. Richard talks to us about some of the haunted happenings at the library over the years and also how is recently sparked national paranormal attention. Do you have a creepy story that took place in Northeastern or Central PA? Do you have an idea for a topic for a future episode? Then we want to hear from you! You can contact the Creepy Side of NEPA team at ghost@wnep.com Be sure to like us on Facebook: WNEP's Creepy Side of NEPA Don't forget to subscribe to our channel on YouTube:  Creepy Side of NEPA

Becky Kaneeeee *ahem* Osterhout joins Bari and Cali to talk product management training, Mat leave during quarantine and Julie's disgusting flip flops.

It's been five years since Acephalix last graced the death metal scene and a lot has happened in that stretch of time. But, the band's upcoming fourth full length, Theothanatology (20 Buck Spin), is the kind of barbaric brutality we've come to think of from the now quintet, yet better, more furious, and nastier than ever. While it's true we'll have to wait just a bit longer to hear it in full, Buke sat down with bassist Erika Osterhout for a wide ranging discussion surrounding this new album, the meaning behind the title, and so much more. We now bring you this conversation in its entirety so grab your beverage of choice, a seat, and enjoy. 9C LINKS: Website | Facebook | Twitter | Instagram 

New neurons have been discovered that generate fever and illness in the brain. Want to learn more about them and how they where discovered then listen in to the latest podcast episode. Dr Jessica Osterhout's Twitter Dr Jessica Osterhout's University Profile The Paper Brain Explained Twitter Brain Explained Website

Amber Loomis, Director of Development & Community Relations at the Osterhout Free Library, 71 S. Franklin Street in Wilkes-Barre, speaking about the history of the library & the adaptations the Osterhout has made during the pandemic. The London Calling Gala & Auction (9/7-10) is being held to allow the Osterhout to continue to meet the needs of the residents of Luzerne County. www.osterhout.info/

POWER OF ONE DAY Good morning, good afternoon good evening to our entire Etown family and welcome to Jay Talking the official Elizabethtown College Athletics podcast. I am your host Casey McGarvey of the Athletic Communications Department. Season one has been a big success and we hope you all continue to support and listen on any of the many podcast platforms. Please rate and subscribe so you are able to get the inside scoop on everything athletics-related and more at Etown. Our seventh guest is not only a dedicated employee of the college but a dedicated alum. Director of Annual Giving Ben Osterhout, class of 2005, joined us to talk about a very important day campus, Power of One day, a 24-hour giving challenge dedicated to supporting Etown students which takes place Tuesday, March 23rd. Not only can you help to meet Elizabethtown's current and emerging learning and scholarship-related needs, but you can also directly support specific programs within our athletic department at one of the links in the episode information. We hope you enjoy this episode and join us in taking part in Power of One Day. POWER OF ONE DAY

What's up everyone it's Captain Kyle Smith and this week I sat down for a Morning Meeting with SDFD Engineer Charles Osterhout. Charles shares his experience running his small business and the challenges he's faced over the last 20 years. Charles has taken the opportunities given to him and made the best out of each situation. From buying his screen printing business for $1 to helping run a Crossfit gym, he's seen a lot. He maximizes his time by working ON his business, not IN his business. That's a concept straight out of the New York Times Best- Selling book The E-Myth by Michael Gerber and allows Charles to work more efficiently. If you'd like to learn more about Charles you can find him on his email at firehausprints@gmail.com I hope you guys enjoy it!

#OnTheStacks Podcast Episode 28 with Amber Loomis, Director of Development and Community Relations at the Osterhout Free Library. Amber shares how her life experiences from a young age inspired her to pursue a career path of giving back to the community and helping less fortunate individuals in the Northeast Pennsylvania region. Engage with me on […]

Irene Martin joins the show to talk about the Friends of the Osterhout Book Sale on Saturday. Miss Prospector's Show? Check out the Prime Cuts Podcast subscribe at Apple Podcasts, Google Podcasts, Spotify or Stitcher Radio from your mobile device. ​

Join me for a deep dive with Dr. Steven Osterhout, aka Dr. O, CEO of Vitality Healthcare, bridging the gap of traditional medicine through research, science, and natural healing strategies from around the world. By learning first-hand how to identify, detoxify, and eliminate the underlying causes of illness to create an authentic opportunity for your good health. Join us to learn more about how you can have a happier and healthier life. Have questions? yourvitalityhc.com & 269-323-4473

Join me for a deep dive with Dr. Steven Osterhout, aka Dr. O, CEO of Vitality Healthcare, bridging the gap of traditional medicine through research, science, and natural healing strategies from around the world. By learning first-hand how to identify, detoxify, and eliminate the underlying causes of illness to create an authentic opportunity for your good health. Join us to learn more about how you can have a happier and healthier life. Have questions? yourvitalityhc.com & 269-323-4473

Are you a health optimizer? Are you fit athlete but still feeling fat? Are you fit on the outside but not so healthy on the inside "under the hood"? Many athletes are fit but not healthy as chronic stress, over training, poor nutrition, oxidative stress and dysbiosis can all lead to being unhealthy "under the hood". How do you know if you are healthy?  How do you be a "health optimizer"? Do you want to improve your immune system?  Dr. Steve talks about ways to improve your health and to build resiliency. Portage native Dr. Steven Osterhout attended Western Michigan University where he attained his Pre-Med degree in Biological Medicine. Dr. Osterhout is a member of the American Academy of Anti-Aging Medicine and the American Academy of Environmental Medicine. He also pursued post-doctoral studies in Clinical Nutrition and is a Board Certified Clinical Nutritionist.  At the age of 12 Dr. Osterhout was diagnosed with Type 1 Diabetes and at 20 he underwent open heart surgery; Experiencing these two profound health challenges so early in life created an overwhelming need to find answers as to why we become—and remain—sick. This fueled a passion for identifying how poor health develops and what can be done to overcome health issues using a functional medicine approach. Dr. Osterhout's personal experience created a respect for what traditional medicine can do, and he obtained an understanding of what traditional medicine fails to do. His concerns with the conventional approach of identifying symptoms and then medicating them led to over twenty-five years of research, science and participation in natural healing strategies from around the world. He learned first-hand that identifying, detoxifying, and eliminating the underlying causes of illness creates an authentic opportunity for good health.  Every person has his or her own unique factors, environmental triggers, and predispositions; Addressing these issues, and many more, creates an opportunity for the body to restore and heal.  yourvitalityhc.com intelligentnutritioninc.com Watch our video interview here on YouTube! Let me know if you have any questions, comments or concerns via www.debbiepotts.net   

Dr. Osterhout joins Tracy Herbert where he talks about living healthy with diabetes. Dr. Osterhout is a Board Certified Nutritionist and Functional Medicine doctor. Facebook: https://www.facebook.com/vitalityhc/ Office: https://www.yourvitalityhc.com/ Shop: https://www.yourvitalityhc.com/shop/

A man of Dutch ancestry, who dates the history of his family in America to 1665, is researching his family history. He happens upon a name, then a photo--"The Osterhouts"--by Harlem Renaissance lion James Van Der Zee. These Osterhouts are Black. He's White. What? Who? Wow! This week on The Janus Adams Show, "Who Did the Shirt on the Line Belong To?" Out guest: conceptual artist, writer, family ancestry researcher, bearer of amazing surprises--Mike Osterhout

Joy Osterhout by Kathryn Kennedy

This is Episode 3, Season 1 of The TMI Project Podcast, Tragedy + Time = Comedy. It was produced in partnership with Radio Kingson with production assistance from Ida Hakkila, Nate Brogan, Marlan Barry and Manuel Blas.Useful Links:Podcast Website: https://www.tmiproject.org/podcast/Twitter: https://twitter.com/tmiprojectFacebook: https://www.facebook.com/tmiprojectInstagram: https://www.instagram.com/tmiproject/YouTube: https://www.youtube.com/channel/UCSe3UtpOEzhQG03PzwVRUqAVimeo: https://vimeo.com/tmiprojectUpstater: https://upstater.com/contributors/sam-osterhout/

(00)  None Of Your Business is Back- (00:41) Cre8 tribe new program. !!! (01:23) 2020 is here baby lets get it. (01:35) Dylan O talks about a five-year plan and what it takes to be awesome. (03:43) The power of Five-year plans. (04:00) How to break your five-year plan into daily actions. (04:50) Healthy and bad habits.  (05:08) Talks about pushups in between Netflix shows as a healthy habit. (05:30) atomic habits  (08:11) ending  @robertdelude @dylanosterhout @tyluer_mikal_chancy Mikal Chancy  https://cre8athletes.clickfunnels.com/optin

Dan Osterhout - How to Keep your Business from Overwhelming your Life Cornerstone Consulting guides your marketing, financial and management strategy so you can lead your business with confidence. Follow us on Instagram @consultwithcornerstone for the daily productivity tips and motivational quotes you need to finish the work week strong. Phone: 610-413-1182 Email: daniel.osterhout@consultwithcornerstone.com Episode sponsored by Live Oak Real Estate - www.LiveOakRealEstate.net

Local artist, hunter, and punctual podcast guest Mike Osterhout came by and chatted with me about his "Church of the Little Green Man", hunting (with supermodels) and more! Truly a pleasure to interview such an interesting man!

This first interview with Keith Boesky, a board member with the Osterhout Group, marked the launch of a 4-day non-stop interview fun fest with technology leaders throughout the VR and AR industry. Dubbed the "Virtual Reality Games & Entertainment Extravaganza", it took place online between July 24-27, 2017.

The gang steps out of their comfort zone to discuss the changes in the ancient atmosphere that resulted in the Great Oxidation Event. Meanwhile, Amanda demonstrates a careless disregard for hands, James gets creative with spelling, and Curt aims for comedic mediocrity. Up-Goer 5 Summary (Amanda Edition): Today the group talks about tiny things that make air that we can breathe. Long, long ago there were many tiny things that made air that we could not breathe. Less long ago there came along some little tiny things that made air that we can breathe. This air that we can breathe made almost all of the other little tiny things die because they could not breathe it. The group talks about these little tiny things that made both good air and bad air and how they made different kinds of rocks and used different kinds of rocks and air to live. References: Lyons, Timothy W., Christopher T. Reinhard, and Noah J. Planavsky. "The rise of oxygen in Earth/'s early ocean and atmosphere." Nature 506.7488 (2014): 307-315. Lalonde, Stefan V., and Kurt O. Konhauser. "Benthic perspective on Earth’s oldest evidence for oxygenic photosynthesis." Proceedings of the National Academy of Sciences 112.4 (2015): 995-1000. Konhauser, Kurt O., et al. "Could bacteria have formed the Precambrian banded iron formations?." Geology 30.12 (2002): 1079-1082. Johnson, Jena E., et al. "Manganese-oxidizing photosynthesis before the rise of cyanobacteria." Proceedings of the National Academy of Sciences 110.28 (2013): 11238-11243. Czaja, Andrew D., Nicolas J. Beukes, and Jeffrey T. Osterhout. "Sulfur-oxidizing bacteria prior to the Great Oxidation Event from the 2.52 Ga Gamohaan Formation of South Africa." Geology 44.12 (2016): 983-986.

Show Notes:  In this episode of The Tiara Talk Show, Paul Osterhout chats with host Tammy Tuckey about being a show producer for the 1994 version of Walt Disney’s “Carousel of Progress” and “New Tomorrowland,” getting a chance to work with Robin Williams on The Timekeeper, how he became the voice of James the teenage son in the Carousel of Progress, and more! Be sure to… - Follow us on Twitter at @TiaraTalkShow: www.twitter.com/TiaraTalkShow - ‘Like’ our Facebook page: www.facebook.com/TheTiaraTalkShow - Follow us on our Tumblr page: thetiaratalkshow.tumblr.com - Follow us on our Google+ page: google.com/+TheTiaraTalkShow - Follow us on our Instagram page: instagram.com/thetiaratalkshow Want to give us your thoughts on this episode? Call us at 1-407-413-9390 and leave us a voicemail! Thanks for listening! “The Tiara Talk Show” is edited, created and hosted by Tammy Tuckey. The Tiara Talk Show is Copyright © 2013-2016 by Tammy Tuckey. All rights reserved.

Full Transcript: [intro music] Host – Dan Keller Hello, and welcome to Episode Seventy-three of Multiple Sclerosis Discovery, the podcast of the MS Discovery Forum. I’m Dan Keller. Today's interview features Donna Osterhout, a cell biologist at Upstate Medical University in Syracuse, New York, USA. Dr. Osterhout talks about a new way of looking at myelin-making cells, which move and change shape in dramatic ways. Current MS drugs take aim at preventing new immune damage. In the future, researchers hope to figure out how to repair myelin and restore function. But first, let’s look at new content on MS Discovery Forum. Spring brings rain, flowers, and a bouquet of scientific meetings related to multiple sclerosis. See the list at msdiscovery.org under the tab “professional resources.” MSDF sent the only journalist to cover the recent meeting of the American Society of Neurochemistry in Denver, but you can count on a blitz of news from the media pack at the next meeting on the calendar – the American Academy of Neurology in April, happening this year in Vancouver, BC, Canada. The number of research papers about multiple sclerosis has doubled in the last 10 years, and many findings are first reported at meetings before publication. Moving on, let’s sample a few of the new papers we found in our weekly PubMed search of the world’s largest medical library, the National Library of Medicine. You can link to each week’s list of curated papers at msdiscovery.org. Related to this week’s podcast, a new paper reviews the latest research about the molecular cues that allow precursor cells to mature and go through the stages of making myelin. These cues come from axons and from other surrounding tissue. Clinical drug development efforts focus on overcoming inhibitory cues, such as with the experimental agent anti-LINGO-1, now completing phase 2 clinical trials for MS and acute optic neuritis by Biogen. The review authors suggest future drugs to repair myelin could boost permissive and promotional cues, which may go wrong in disease. The paper is published by researchers at the Virginia Commonwealth School of Medicine in the journal Experimental Neurology. Another report updates the Cochrane systematic review on teriflunomide, a daily oral medication for relapsing remitting MS marketed under the brand name Aubagio by Sanofi Genzyme. Cochrane’s systematic reviews are ranked among the highest level of medical evidence, because of the rigorous independent analysis of multiple studies, including randomized controlled trials. The authors write that, as a single drug, the high dose of teriflunomide was as effective as interferon beta 1-a, while the low dose was less effective. They recommended longer follow-up analyses and noted that the available evidence was low-quality, as well as subject to bias, in part because all studies were sponsored by pharmaceutical companies. In general, side effects were mild to moderate and do not usually lead to treatment being stopped, but the higher dose is more prone to cause these side effects. The study is available in the Cochrane Library. The final editor’s pick this week takes a fresh look at how medical images transform a patient’s view of her own body. The paper describes an artistic collaboration between Devan Stahl, a bioethicist at Michigan State University with multiple sclerosis, and her sister Darian Goldin Stahl, a printmaker. The resulting art – some of it life sized – superimposes Devan’s narrative and MRI images with body photos. Devan wrote in the paper that the art collaboration has made it easier to talk about her MS. The paper is published in the journal Medical Humanities. If you're in town for the big Neurology meeting, you can catch Darian’s artist talk on April 17 at 2 pm at Malaspina Printmakers in Vancouver, Canada. [transition music] And now to our interview. We caught up with Donna Osterhout in Denver, Colorado at the March meeting of the American Society for Neurochemistry. She organized a symposium that told a new story about myelin-making cells. In different labs, researchers started looking for clues in the radical shape changes that occur in the cells in their normal process of making myelin. These oligodendrocyte precursor cells sprout “arms” to reach out and touch neighboring axons. Then they push out slabs of fatty membrane and wrap them around and anchor them to the axons. In multiple sclerosis and other demyelinating diseases, the immune system attacks this myelin wrap, and the cells cannot keep up with repair. The unprotected axons may be damaged or destroyed, causing the worsening disability of MS. Learning how the cells make myelin may pave the way toward new therapeutic agents to repair demyelinated axons and restore function. Dr. Osterhout spoke with our executive editor, Carol Cruzan Morton. Interviewer – Carol Cruzan Morton So we are here, in Denver, at the annual meeting of the American Society for Neurochemistry, and you've put together a very interesting panel on a new way of looking at myelin. So can you sort of set the scene for us when you're talking about the myelin research that you're working on? Interviewee – Donna Osterhout Well, myelin is a specialized membrane that is wrapped around axons; it occurs in the last step of development. And oligodendrocyte progenitor cells are the cells that form myelin. They are going to migrate out through the developing brain and they're going to extend processes that come in contact with axons that need to be myelinated. And when they get the appropriate signals, they are going to start a process by which they synthesize and extend a large membrane, which wraps around this axon many times and compacts and forms myelin. The way that this happens has been a mystery thus far, but recent research suggests that there has to be a lot of rearrangements of the internal cytoskeleton for this to happen. And so the symposium was organized to talk about how the cytoskeleton might be changing to allow for this membrane wrapping and myelin formation. MSDF Can you tell me more about the cytoskeleton? Dr. Osterhout The cytoskeleton is comprised of specialized proteins within cells, and every cell has a cytoskeleton; it gives it shape, but it also allows it to migrate, differentiate, and extend processes, so cells wouldn't be able to do much without a cytoskeleton. And in the case of oligodendrocytes, there are a lot of cytoskeletal rearrangements that occur to allow for myelination. MSDF Can you tell me more about the emerging view about how myelination may be working based on this new way of looking at it? Dr. Osterhout Initially, we know that there are early signals that trigger extensive process outgrowth from these cells. Once the axon sends a signal to the oligodendrocyte progenitor cell, they start to put out many, many processes, synthesize myelin proteins, and make this big membrane that will wrap around the axon. What winds up happening is that in the past everybody thinks that we've needed a driving force so that something pushes this forward, and it had been thought that perhaps the actin cytoskeleton was the driving force behind this. The newer research indicates that initially you have to have signals that trigger the process outgrowth, but this is followed by an actual disassembly of the actin cytoskeleton. So it's somewhat opposite of what we had thought previously. MSDF Can you tell me more about the steps that are involved in the process of myelinating that you and your colleagues have been discovering? Dr. Osterhout Well, the initial step is the activation of a cellular kinase called Fyn tyrosine kinase; this is the earliest step in the differentiation of these progenitor cells. Fyn will be activated by any number of signals from the axon including, for example, glutamate that's released. And once Fyn is active, it initiates a rearrangement of cytoskeletal proteins called microtubules in order to facilitate process outgrowth so we can extend processes to form this membrane. In later stages, then we have Fyn helping to trigger the synthesis of myelin proteins, and then you start to get other proteins active that will disassemble the actin cytoskeleton. There is even some evidence that perhaps myelin basic protein can do this. So Fyn signaling will turn on early and promote the synthesis of myelin basic protein, and then myelin basic protein will proceed down these processes and help to disassemble the actin cytoskeleton so the membrane can wrap around the axon. MSDF Can you describe what the cells look like when they're going through this process? Dr. Osterhout Well, this is really interesting to study, especially in vitro. You can set up myelinating cultures of oligodendrocyte progenitor cells. They're very simple cells, they're like bipolar, two to three processes, and that's the earliest progenitor that we might look at. But once you trigger differentiation, they start to put out processes in a somewhat predictable manner. They will first extend five processes, and then these five processes start branching And they produce these intricate branches. At some point these mature cells will actually look like a lace doily; they are spectacular with the cell body in the center and all these highly branched processes surrounding it. And then you see a transformation of these processes into this huge membrane sheet, and in the absence of an axon it's just going to cover the tissue culture dish; it's amazing how large this can get. But if you had an axon in the culture, this membrane sheet would just form myelin. They would form a myelin segment wrapping around the axon. MSDF That’s so interesting. And then can you say, adding to that picture, the steps that are happening in those process that you and your colleagues have been discovering? Dr. Osterhout So when you have the initial process outgrowth, you have Fyn tyrosine kinase active, and that facilitates the initiation and that extensive process outgrowth. But the transition between the process outgrowth and the formation of membrane sheets is going to be the disassembly of the actin cytoskeleton. MSDF And that's the big news is that the actin cytoskeleton is breaking down instead of pushing the myelin forward as it's making its multiple wraps around? Dr. Osterhout Yes, this seems to be the way that this is happening mechanistically. The formation of that myelin membrane requires the actin disassembly, and two of the speakers that we had in our symposium gave evidence to this, using several different experimental systems. And then ultimately when you're going to anchor this myelin sheath, and you can get some specializations in the axonal membrane, and this is what one of the speakers talked about, anchoring the perinodal loops, kind of the ends of the myelin segment. And so we have a process by which we have extensive process outgrowth triggered by Fyn. Then once you get the process outgrowth, you have actin disassembly and you form these membrane sheets, and then they would wrap around the axon, forming myelin, and then you would stabilize it with special proteins in the axon that stabilize the ends at the perinodal loops. MSDF So what does this have to do with diseases like multiple sclerosis? Dr. Osterhout That's a very good question. If we understand what goes on in development, then we might be able to predict how we could facilitate this process in a demyelinating disease like multiple sclerosis. We do have oligodendrocyte progenitor cells in our brain and spinal cord. They persist as a population throughout adulthood. And any time you have a lesion or a trauma to the brain, and especially if you get demyelination, then you'll have these cells migrate to the area of demyelination. And if we can encourage them to remyelinate, they would undergo the same steps. We have shown evidence that the inflammation and other conditions in a demyelinating disease upregulates chondroitin sulfate proteoglycans, and these can actually inhibit the process outgrowth and remyelination by oligodendrocytes, because they ultimately inhibit the activation of Fyn kinase. So if you're considering a disease process, you want to stimulate these steps. And you want to look for agents that might trigger and make sure that these steps proceed, or neutralize things that would be present in the lesion that would inhibit this. MSDF One interesting aspect of your work, and perhaps of science more generally, is that some of these discoveries with relevance to multiple sclerosis come from your work on spinal cord injury. Can you talk about how that works in science? Dr. Osterhout Well, spinal cord injury is another type of lesion, it's a specialized lesion; you have damage to axons as well as demyelination due to trauma. But in diseases in general in the brain and the spinal cord, whenever you have an injury process or inflammation or some kind of destruction of tissue, you get an inflammation and immune influx, and you will get a process called reactive gliosis. And this is common to many diseases that you see in the brain. For example, you can see it easily in spinal cord injury, it's been well documented. You can see these proteoglycans' reactive gliosis in multiple sclerosis, you can see it in Alzheimer's disease, Parkinson's disease, and other conditions, because they all have a common element that you've got some kind of inflammation occurring and tissue destruction occurring at a specific place. MSDF Getting back to multiple sclerosis and the work on how cells myelinate axons, what are the next big questions that you and your colleagues are asking? Dr. Osterhout Well, there still are a lot of questions about exactly how this myelination process is accomplished even during development; we don't fully understand all of the triggers that would activate this process. And, likewise, we don't always understand things that might inhibit this process. So we need to more fully characterize what's going on in development so that we can take a look at it in the remyelinating situations, either in spinal cord injury, or multiple sclerosis, or any other demyelinating condition. MSDF Well, that's really interesting. Well, thank you for taking the time to explain the research. Dr. Osterhout And thank you for your interest; it's been my pleasure. [transition music] MSDF Thank you for listening to Episode Seventy-three of Multiple Sclerosis Discovery. This podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Carol Cruzan Morton. Msdiscovery.org is part of the nonprofit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is Vice President of Scientific Operations. Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances. [outro music]  

Jon Osterhout

After the cache we headed back to The Living Room and had the band play us a song upstairs in Googie's Lounge. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Sam meets up with the Chris Koza at the Living Room on the Lower East Side, and then geocaches in the neighborhood with the whole band. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Total Babes tires of geocaching and plays a tune. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Sam goes geocaching in Central Park with Total Babes. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

We headed back to The Bell House for a beer and some sweet, sweet tunes in the second half of our day with Thousands. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Thousands and Sam go for a hike from The Bell House in Gowanus, Brooklyn, to a cache in the neighborhood. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

The second half of our day with Langhorne Slim saw us return to Bait & Tackle in Red Hook Brooklyn, the bar that will be our home base for season 2. The band sat down, we had a beer, then they played... On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Langhorne Slim and the Law join the Geocachers team for a little geocaching in the Red Hook neighborhood of Brooklyn. Only problem was that we couldn't find the geocache. It took a while, but... On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

In the second portion of our day with the Smoke Fairies they played a song for us called "Erie Lakawanna". On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

We spent the day out with the UK duo Smoke Fairies in this episode. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

We end our day with Ólöf Arnalds with her singing "Lucky Old Sun" for us in her publicist's apartment. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Icelandic singer-songwriter Ólöf Arnalds goes geocaching with Sam in Prospect Park. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

At the end of our day with Nick Diamonds we found this cool amphitheater on the East River where Nick Diamonds performed an acoustic cover of Daniel Johnston. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

In this episode Sam goes geocaching with Nick Diamond (of bands like Islands and the Unicorns). The go hunting for a cache called "NY Yankee #49". On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

For part 2 of our episode with Paul Dempsey he performs "Out the Airlock" outside at the geocache. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Get Episode 1, part 1 of Geocachers, an interview with Paul Dempsey, here. On Geocachers we meet up with some of our favorite musicians, comedians, writers, and all-round entertainers to explore New York, one geocache at a time. Sometimes we start at a bar – although sometimes we don’t – and our adventures take us through parts of the neighborhoods you don’t usually get to see, while the conversation with the guests likewise leads you down unchartered territory: Paul Dempsey talks about physics; Nick Diamonds talks about baseball.

Norah Jones and Gabe Liedman join Sam and the Radio Happy Hour crew at a space camp in Luck, WI. All seems kosher until Cosmonaut Yvgeny Bonerman's wife turns up dead. Also look out for the surprise appearance from Cloud Cult.

Suckers, Tim Kasher, Arden Myrin, and Joe Mande join the Radio Happy Hour crew as they get snowed in at an office holiday party. Only the person who invited them might be a ghost. And Tim Kasher slept with her. Gross.

Listen as VPs David Bazan and Max Silvestri try to solve the murder of the company CEO with devilish consultant Jesse Eisenberg.

Juan from Abe Vigoda and Marcellus Hall join the Radio Happy Hour crew and Sam's detective agency as they are invited to billionaire comedian Ted Alexandro's home to investigate a murder.

Sam winds up as a professional wrestling ref in Montana in a bout between The Shakespearean Punisher (Arthur Phillips), his manager Dave Hill, Rusty Trombone, and Osama bin Droppin' Elbows. But Osama's manager, Elizabeth Ziman of Elizabeth & the Catapult has some startling news at the opening of the bout

In episode #18 the Radio Happy Hour crew returns to Manhattan, Minnesota. Sam’s tending bar at The Ascot while Franz Nicolay does taxes for the town. Arden Myrin joins them for a drink before Michael Dukakis and Michele Bachmann wander into the Ascot and someone winds up dead. It’s the political thriller Clive Owen turned down, Episode #18 of Radio Happy Hour, “The Tax Murderer.”

This is a little episode we call "Selling Out." See it's the penultimate episode of Radio Happy Hour, and we tried to make the show keep working by selling tons of ads for the show, but that didn't really...well...you'll see. We didn't have room for a murder mystery because we sold the whole show to advertisers. The real losers were our guests, who didn't get to be accused of murder at all. Nonetheless we convinced Sun Airway, Hank & Cupcakes, and Jared Logan to sell out with us. And our pals John & Molly Knefel came along to do a little selling out of their own.

Listen as Josh Grier (Tapes 'n Tapes) coaches a rough housing class for criminals. Someone nearly beats Chris Koza to death with a bag of doorknobs, Jeremy Messersmith begrudgingly saves him, and Geoff Herbach proves how powerful his haunches are.

Listen to Jolie Holland and Jessi Klein on Radio Happy Hour as Jessi's Valentine's Day singles mixer on a dark highway goes awry.

Listen to Andrew WK in Radio Happy Hour's tribute to John Hughes' The Breakfast Club.

Listen to The Hold Steady and Chuck Klosterman on Radio Happy Hour as they pass through Manhattan Minnesota and find themselves embroiled in a murder plot.

Listen to Norah Jones on Radio Happy Hour as a motel management intern.

Listen to Tunde Adebimpe and Kumail Nanjiani on Radio Happy Hour as Tunde's camp for ineffectual men turns into a crime scene.