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Could generative AI assist in extending access to vulnerable populations and begin to bridge the gap in disparities? In this Q&A, Davey Smith, MD, MAS, an infectious disease specialist and virologist at the University of California, San Diego, joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to explore the implications of large language models for improving patient outcomes. Related Content: Will Generative AI Tools Improve Access to Reliable Health Information?
In today's episode, we catch up with the trailblazer of aerial surfing and early IPS pro, Davey Smith @davey_smith_bluestone.Growing up amidst the allure of right-point breaks, Davey found himself in a unique position as a goofy foot. Always on the lookout for that elusive left in a land dominated by rights, Davey's journey in the world of surfing is nothing short of inspiring. As one of the original Channel Island team riders, he forged a lifelong bond with legendary shaper Al Merrick from day one.In our conversation, Davey shares the story of how his passion for skating influenced his approach to surfing, giving birth to "The Air." This innovative style became a hallmark of his surfing career and left an indelible mark on the sport.After his illustrious pro career, Davey transitioned seamlessly into nurturing the next generation of surfers. He ran a surf school of the stars in the picturesque setting of Santa Barbara, imparting his wisdom to those eager to ride the waves. But Davey's journey didn't stop there; he took his expertise to the shaping room, becoming a key figure in Channel Islands Surfboards.Today, surf enthusiasts have the opportunity to ride their own custom Glider shaped by the hands of the surfing maestro himself, Davey Smith. Join us as we dive into the highs and lows of Davey's remarkable journey, exploring the evolution of aerial surfing, his close ties with Al Merrick, and the legacy he continues to shape in the world of surfboard design. And did he lose his boardshorts in his Pipeline Masters heat with 10,000 people on the beach? Find Out!Get a custom Glider from Davey: www.daveysmithsurf.com Support the showBUY THE ENDLESS SUMMER BOX SET HERE!If you like the QuiverCast here are some ways to help us keep going! I always like Coffee! Buy me a Coffee! Become a Patreon for as little as a Buck a Month! Patreon Find Us: Website: thequivercast.com Instagram: @quiver_cast Facebook: The QuiverCast Twitter: @The_QuiverCast Sound Editing by: The Steele Collective
Listen on Apple, Google, Spotify, and other platforms. Davey gives an overview of his work at UC San Diego [02:23] How did Davey end up down the path toward infectious diseases? [03:23] Davey talks about the first time he heard about COVID-19 [06:02] How did Operation Warp Speed come together and when did Davey get involved? [07:21] Davey shares his observations on Model Medicines [11:25] Davey describes the technology Model Medicines focus on and how they apply it to many areas [13:10] Davey talks about his current involvement such as preclinical testing and preparing for clinical trials [15:05] Davey explains why COVID-19 and other respiratory viruses will continue to be a threat, and why new treatments are necessary [16:43] Davey emphasizes the need for investing in the science and research to improve next-generation drugs [00:18:55] Davey shares how AI is changing the way drug development is being approached today [20:01] On the FDA's flexibility and alignment with Model Medicines' plans for testing and development [20:48] Davey talks about future plans for Model Medicines, his plans on launching a clinical trial for respiratory viruses, and basket trial [00:22:23] Davey shares his take on the technology communities and collaborative and problem-focused culture of San Diego [23:40] Davey shares his favorite taco spot on Washington Street, El Cuervo [00:27:05] Follow Davey LinkedIn University of California San Diego Website | LinkedIn Check out our Tacos and Tech Tacos Database to learn where our local SD entrepreneurs and leaders satisfy their taco crave!
Vamos dar uma passada na capacidade de digerir a lactose, o açúcar do leite. Fazemos isso através da lactase, uma enzima que quase não existe na vida adulta. Alguns adultos conseguem manter esta enzima presente. vamos entender o que foi descoberto em um estudo de julho de 2022. Referência: Evershed, R.P., Davey Smith, G., Roffet-Salque, M. et al. Dairying, diseases and the evolution of lactase persistence in Europe. Nature 608, 336–345 (2022). https://doi.org/10.1038/s41586-022-05...
CME in Minutes: Education in Rheumatology, Immunology, & Infectious Diseases
Please visit answersincme.com/TAC860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in infectious diseases discusses the early identification and treatment of patients with COVID-19 who are at a higher risk of progression to severe illness. Upon completion of this activity, participants should be better able to: Identify nonhospitalized patients with COVID-19 who have risk factors for progression to severe illness; Describe national guideline recommendations for the therapeutic management of nonhospitalized patients with COVID-19 who are at risk for progression to severe illness; and Outline a personalized management approach to enhance outcomes for nonhospitalized patients who are diagnosed with COVID-19 and are at risk for progression to severe illness.
Please visit answersincme.com/TAC860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in infectious diseases discusses the early identification and treatment of patients with COVID-19 who are at a higher risk of progression to severe illness. Upon completion of this activity, participants should be better able to: Identify nonhospitalized patients with COVID-19 who have risk factors for progression to severe illness; Describe national guideline recommendations for the therapeutic management of nonhospitalized patients with COVID-19 who are at risk for progression to severe illness; and Outline a personalized management approach to enhance outcomes for nonhospitalized patients who are diagnosed with COVID-19 and are at risk for progression to severe illness.
Monkeypox has been declared a NATIONAL public health emergency by the Biden administration... Travis Dale fill in for Lou and talks to the Chief of Infectious Diseases and Global Public Health Professor of Medicine at UCSD, Dr. Davey Smith, and try to dispel some myths about this disease… and answer the question, “Should I be worried now?” Russia throws the book at WNBA star Brittney Griner... but are they justified in doing so? Newsom declares war on Conservative states and California native (and quite possibly the greatest actor of our generation) Dwayne "the Rock" Johnson tries In-N-Out for the first time in his life?
Mleko jest smaczne, zdrowe i stanowi nasz pierwszy pokarm, ale jak to się stało, że możemy go pić także jako dorośli? Pszczoły są świetnymi zapylaczami na lądzie, ale czy ten proces odbywa się też w morskich głębinach, a jeśli tak to kto pełni funkcję owadów? W dzisiejszym odcinku podkastu Naukowo opowiem też o morderczych komórkach naszego ciała zabijających inne komórki bez wyraźnego powodu oraz o mini robocie zbudowanym z DNA. Przyjrzymy się też długości snu o dzieci i jak wpływa ona na ich długoterminowy rozwój. Zapraszam serdecznie!Jeśli uznasz, że warto wspierać ten projekt to zapraszam do serwisu Patronite, każda dobrowolna wpłata od słuchaczy pozwoli mi na rozwój i doskonalenie tego podkastu, bardzo dziękuję za każde wsparcie!Zapraszam również na Facebooka, Twittera i Instagrama, każdy lajk i udostępnienie pomoże w szerszym dotarciu do słuchaczy, a to jest teraz moim głównym celem :) Na stronie Naukowo.net znajdziesz więcej interesujących artykułów naukowych, zachęcam również do dyskusji na tematy naukowe, dzieleniu się wiedzą i nowościami z naukowego świata na naszym serwerze Discord - https://discord.gg/mqsjM5THXrŹródła użyte przy tworzeniu odcinka:Mills, A., Aissaoui, N., Maurel, D. et al. "A modular spring-loaded actuator for mechanical activation of membrane proteins". Nat Commun 13, 3182 (2022). https://doi.org/10.1038/s41467-022-30745-2E. Lavaut, M.-L. Guillemin, S. Colin, A. Faure, J. Coudret, C. Destombe, M. Valero. "Pollinators of the sea: A discovery of animal-mediated fertilization in seaweed". https://doi.org/10.1126/science.abo6661Evershed, R.P., Davey Smith, G., Roffet-Salque, M. et al. "Dairying, diseases and the evolution of lactase persistence in Europe". Nature (2022). https://doi.org/10.1038/s41586-022-05010-7Maayan Zohar-Fux, Aya Ben-Hamo-Arad, Tal Arad, Marina Volin, Boris Shklyar, Ketty Hakim-Mishnaevski, Lilach Porat-Kuperstein, Estee Kurant, Hila Toledano. "The phagocytic cyst cells in Drosophila testis eliminate germ cell progenitors via phagoptosis". https://doi.org/10.1126/sciadv.abm4937Zalecana ilość snu dla populacji dziecięcej: konsensus Amerykańskiej Akademii Medycyny Snu. Shalini Paruthi, MD, Lee J. Brooks, MD, Carolyn D'Ambrosio, MD, Wendy A. Hall, PhD, RN, Suresh Kotagal, MD, Robin M. Lloyd, MD, Beth A. Malow, MD, MS, Kiran Maski, MD, Cynthia Nichols, PhD, Stuart F. Quan, MD, Carol L. Rosen, MD, Matthew M. Troester, DO, and Merrill S. Wise, MD. "Recommended Amount of Sleep for Pediatric Populations: A Consensus Statement of the American Academy of Sleep Medicine". https://doi.org/10.5664/jcsm.5866University of Maryland School of Medicine. "Children Who Lack Sleep May Experience Detrimental Impact on Brain and Cognitive Development That Persists Over Time, UM School of Medicine Study Finds". https://www.newswise.com/articles/children-who-lack-sleep-may-experience-detrimental-impact-on-brain-and-cognitive-development-that-persists-over-time-um-school-of-medicine-study-finds?sc=rslaFan Nils Yang, PhD, Weizhen Xie, PhD, Ze Wang, PhD, "Effects of sleep duration on neurocognitive development in early adolescents in the USA: a propensity score matched, longitudinal, observational study", https://doi.org/10.1016/S2352-4642(22)00188-2
3/19/22 Synopsis: NWA Crockett Cup 2022 Night 1 fallout with 411Mania.com Reporter and Columnist Lee Sanders as NWA's tag team division got the spotlight with help from the Briscoes, Doug Williams and Davey Smith, La Rebellion, Hawx Aerie and much more!!! COVERING THE LATEST IN WRESTLING, ENTERTAINMENT, AND BEYOND SINCE 2011.BROUGHT TO YOU IN PARTY BY https://www.rotellaresale.com/YOUR PREMIER COLLECTIBLES, TOYS AND NOVELTY RETAILER=======NWA CROCKETT CUP NIGHT ONE RESULTS=======***Pre-show Magic Jake Dumas defeated Captain YUMA (with Danny Deals and Jeremiah Plunkett) by pinfall***Pre-show The Bad News Boyz (Brandon Tate and Brent Tate) defeated Violence Is Forever (Dominic Garrini and Kevin Ku), The Rip City Shooters (Joshua Bishop and Wes Barkley), and The Heatseekers (Elliott Russell and Sigmon) by pinfalll in a Fatal Four-way tag team***Play-In Match to determine the 16 seed in the Crockett Cup tournament***Pre-show The Briscoe Brothers (Jay and Mark) defeated The NOW (Hale Collins and Vik Dalishus) by pinfall in a Crockett Cup first round match***Hawx Aerie (Luke Hawx and PJ Hawx) defeated The End (Odinson and Parrow) by pinfallCrockett Cup first round match***The Cardonas (Mike Knox and VSK) defeated Matthew Mims and The Pope by pinfallCrockett Cup first round match***The Dirty Sexy Boys (Dirty Dango and JTG) defeated Aron Stevens and The Blue Meanie by pinfall Crockett Cup first round match***Gold Rushhh (Jordan Clearwater and Marshe Rockett) defeated Strictly Business (Chris Adonis and Thom Latimer) by pinfallCrockett Cup first round match***The Commonwealth Connection (Doug Williams and Harry Smith) defeated The Ill Begotten (Alex Taylor and Rush Freeman) by pinfallCrockett Cup first round match***La Rebelión (Bestia 666 and Mecha Wolf) defeated The Bad News Boyz (Brandon Tate and Brent Tate) by pinfallCrockett Cup first round match***The Cardonas (Mike Knox and VSK) defeated The Fixers (Jay Bradley and Wrecking Ball Legursky) by pinfallCrockett Cup quarterfinals tag team match***The Briscoe Brothers (Jay and Mark) defeated The Dirty Sexy Boys (Dirty Dango and JTG) by pinfallCrockett Cup quarterfinals tag team match***La Rebelión (Bestia 666 and Mecha Wolf) defeated Luke and PJ Hawx by pinfallCrockett Cup quarterfinals handicap match***The Commonwealth Connection (Doug Williams and Harry Smith) defeated Gold Rushhh (Jordan Clearwater and Marshe Rockett) via submissionSUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshowLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: http://bit.ly/1yByytuTUNE IN: https://tunein.com/podcasts/Sports--Recreation-Podcasts/The-RCWR-Show-with-Lee-Sanders-p534304/===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW
In 1993 Davey Smith walked into a Calgary bar, not knowing his life was about to change forever. Experience the regrettable confrontation, the weird turns of events, and crazy court intrigues when Nick and Chango discuss THE TRIAL OF THE BRITISH BULLDOG! Sources: -Titan Shattered, by James Dixon -Lethbridge Herald30 Jan 1996, Lethbridge, Alberta -Brandon Sun01 Feb 1996, Brandon, Manitoba -Lethbridge Herald02 Feb 1996, Lethbridge, Alberta -Medicine Hat News08 Jan 1994, Medicine Hat, Alberta -Winnipeg Free Press03 Jan 1994, Winnipeg, Manitoba
Today is the return of the Doc – my wife's favorite guest, doctor Davey! We talk about the latest on Covid (a little) and he shares some fun tales from the ER (No, he was not an ER Doc, but it sounds more catchy than “tales from the virologist and contagious specialist”) We talk about myths and facts in the supplement fields (yeah, you are probably wasting a lot of money, I was) The placebo effect, Keto versus Mediterranean diet, Cryotherapy, B-12 shots and more! We also learn that to be a drug, there has to be a controlled series of tests, but supplements and other stuff need no such tests. So if you have a general question, Davey is the perfect guest of patient and funny, but VERY non committal about results – he relies 100% on data and test results, no emotion1 He is like Spock and Dr. McCoy had a baby! Follow him @ DaveySmithMD on your socials.
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Get the latest information about COVID-19 vaccines. Learn about when vaccines may be available for children, equitable distribution efforts, and how we can work together to overcome vaccine hesitancy. David Brenner, MD is joined in conversation by Shira Abeles, MD, Susan Little, MD, Davey Smith, MD, Stephen Spector, MD, and Alejandra Sotelo-Solis. Series: "UC San Diego Health Talks" [Health and Medicine] [Show ID: 36721]
Get the latest information about COVID-19 vaccines. Learn about when vaccines may be available for children, equitable distribution efforts, and how we can work together to overcome vaccine hesitancy. David Brenner, MD is joined in conversation by Shira Abeles, MD, Susan Little, MD, Davey Smith, MD, Stephen Spector, MD, and Alejandra Sotelo-Solis. Series: "UC San Diego Health Talks" [Health and Medicine] [Show ID: 36721]
Innovative board builder, coach, father figure to countless youths, Ben Aipa passed away on January 15th due to complications suffered from a heart attack and Alzheimer's. Today we survey Ben's influence and celebrate the many benefits we enjoy thanks to his impact. Featuring interviews with Ben himself, Akila Aipa, Roger Hinds, Matt Calvani, and Davey Smith. Enjoy! Learn more about your ad choices. Visit megaphone.fm/adchoices
If you were around in the 1980's you're probably familiar with the Healthy Food Pyramid model that was plastered on your cornflake packets and other carbohydrate-heavy packaged goods, but with the country's rising obesity epidemic, it's time to reflect: is this nutritional model the healthiest choice for Australians? And if not, what is? In this episode, I dissect each layer of the pyramid and give my recommendations so you can make more informed healthy food choices based on the latest nutrition science. Get your hands on my brand new Metabolic Symptoms Tracker in my new Empowered Women's Self-Health Revolution at bit.ly/selfhealthrevolution References: [1] Davis, W. A., Peters, K. E., Makepeace, A., Griffiths, S., Bundell, C., Grant, S., Ellard, S., Hattersley, A. T., Paul Chubb, S. A., Bruce, D. G., & Davis, T. (2018). Prevalence of diabetes in Australia: insights from the Fremantle Diabetes Study Phase II. Internal medicine journal, 48(7), 803–809. https://doi.org/10.1111/imj.13792 [2] Bantle J. P. (2009). Dietary fructose and metabolic syndrome and diabetes. The Journal of nutrition, 139(6), 1263S–1268S. https://doi.org/10.3945/jn.108.098020 [3] Hills, R. D., Jr, Pontefract, B. A., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019). Gut Microbiome: Profound Implications for Diet and Disease. Nutrients, 11(7), 1613. https://doi.org/10.3390/nu11071613 [4] Dashti, H. M., Mathew, T. C., Hussein, T., Asfar, S. K., Behbahani, A., Khoursheed, M. A., Al-Sayer, H. M., Bo-Abbas, Y. Y., & Al-Zaid, N. S. (2004). Long-term effects of a ketogenic diet in obese patients. Experimental and clinical cardiology, 9(3), 200–205. [5] Yancy, W. S., Jr, Foy, M., Chalecki, A. M., Vernon, M. C., & Westman, E. C. (2005). A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutrition & metabolism, 2, 34. https://doi.org/10.1186/1743-7075-2-34 [6] Samsel, A., & Seneff, S. (2013). Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary toxicology, 6(4), 159–184. https://doi.org/10.2478/intox-2013-0026 [7] Swanson, Nancy & Hoy, Judy & Seneff, Stephanie. (2016). Evidence that glyphosate is a causative agent in chronic sub-clinical metabolic acidosis and mitochondrial dysfunction. International Journal of Human Nutrition and Functional Medicine. 4. 9. [8] Daley, C. A., Abbott, A., Doyle, P. S., Nader, G. A., & Larson, S. (2010). A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef. Nutrition journal, 9, 10. https://doi.org/10.1186/1475-2891-9-10 [9] Hooper, L., Martin, N., Abdelhamid, A., & Davey Smith, G. (2015). Reduction in saturated fat intake for cardiovascular disease. The Cochrane database of systematic reviews, (6), CD011737. https://doi.org/10.1002/14651858.CD011737 [10] Dashti, H. M., Mathew, T. C., Hussein, T., Asfar, S. K., Behbahani, A., Khoursheed, M. A., Al-Sayer, H. M., Bo-Abbas, Y. Y., & Al-Zaid, N. S. (2004). Long-term effects of a ketogenic diet in obese patients. Experimental and clinical cardiology, 9(3), 200–205. [11] Neustadt, John. (2005). The food pyramid and disease prevention. Integrative Medicine. 4. 14-19.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.244293v1?rss=1 Authors: Elsworth, B. L., Lyon, M. S., Alexander, T., Liu, Y., Matthews, P., Hallett, J., Bates, P., Palmer, T., Haberland, V., Davey Smith, G., Zheng, J., Haycock, P., Gaunt, T. R., Hemani, G. Abstract: Data generated by genome-wide association studies (GWAS) are growing fast with the linkage of biobank samples to health records, and expanding capture of high-dimensional molecular phenotypes. However the utility of these efforts can only be fully realised if their complete results are collected from their heterogeneous sources and formats, harmonised and made programmatically accessible. Here we present the OpenGWAS database, an open source, open access, scalable and high-performance cloud-based data infrastructure that imports and publishes complete GWAS summary datasets and metadata for the scientific community. Our import pipeline harmonises these datasets against dbSNP and the human genome reference sequence, generates summary reports and standardises the format of results and metadata. Users can access the data via a website, an application programming interface, R and Python packages, and also as downloadable files that can be rapidly queried in high performance computing environments. OpenGWAS currently contains 126 billion genetic associations from 14,582 complete GWAS datasets representing a range of different human phenotypes and disease outcomes across different populations. We developed R and Python packages to serve as conduits between these GWAS data sources and a range of available analytical tools, enabling Mendelian randomization, genetic colocalisation analysis, fine mapping, genetic correlation and locus visualisation. OpenGWAS is freely accessible at https://gwas.mrcieu.ac.uk, and has been designed to facilitate integration with third party analytical tools. Copy rights belong to original authors. Visit the link for more info
David "Davey" Smith, MD outlines the keys to survival including testing to know where the pathogen is, treating those who have it, and developing vaccines to protect those at risk. He shares what types of testing and treatments are currently available and how research is progressing. Series: "UC San Diego Foundation Board" [Health and Medicine] [Show ID: 36141]
David "Davey" Smith, MD outlines the keys to survival including testing to know where the pathogen is, treating those who have it, and developing vaccines to protect those at risk. He shares what types of testing and treatments are currently available and how research is progressing. Series: "UC San Diego Foundation Board" [Health and Medicine] [Show ID: 36141]
When George Davey-Smith started work as an epidemiologist, he hoped to prove that the cause of coronary disease in South Wales soon after the miner's strike was Thatcherism. The miners said they thought it was a combination of having a poor constitution and bad fortune. Thirty years later, George admits he would have done well to listen to them. Having spent decades studying the influence on our health of a huge number of variables, from lifestyle factors like car ownership to our genetic inheritance and most recently epi-genetic effects; George has concluded that whether or not individuals get sick is, to a significant extent, down to chance. But that's not to say that public health interventions are a waste of time.They can boost the overall health of a population, significantly. George is director of the MRC Integrative Epidemiology Unit at the University of Bristol. Producer: Anna Buckley.