Podcasts about strongyloides

On episode #77 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/13/25 – 3/26/25. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral Food is medicine for human immunodeficiency virus: improved health and hospitalizations in the changing health through food support (chefs-hiv) pragmatic randomized trial (JID) The epidemiology and burden of human parainfluenza virus hospitalizations in u.s. children (Journal of the Pediatric Infectious Diseases Society) Bacterial Epidemiology and outcomes of bloodstream infections in patients in a burns intensive care unit: an eight-year retrospective study(OFID) Prophylactic vancomycin in the primary prevention of clostridium difficile in allogeneic stem cell transplant(Transplant Infectious Disease) Incidence of scrub typhus in rural south India (NEJM) Antibiotic treatment for 7 versus 14 days in patients with bloodstream infections(NEJM) Blood Culture–Negative Endocarditis(Journal of the American Heart Association) Brucella suis Infection in Cardiac Implantable Device of Man Exposed to Feral Swine Meat, Florida, USA (CDC Emerging Infectious Diseases) Hyperbilirubinemia at hospitalization predicts nosocomial infection in decompensated cirrhosis (Hepatology Communicatons) Fungal The Last of US Season 2 (YouTube) Fungal Infections in People Who Use Drugs (OFID) IDSA 2025 guideline update on the treatment of asymptomatic histoplasma pulmonary nodules (histoplasmomas) and mild or moderate acute pulmonary histoplasmosis in adults, children, and pregnant people(IDSA: Infectisous Disease Society of America) Changing trends in the sources and volumes of clinical cultures with Candida auris at a large health system, 2019-2023 (American Journal of Infection Control) Diagnostic test accuracy of the Fungitell serum (1→3)-β-D-glucan assay for the diagnosis of Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis (CMI: Clinical Microbiology and Infection) Parasitic Impact of Strongyloides stercoralis Coinfection on Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis (OFID) Hematology thin smears perform equally to parasitology thick and thin blood smears for the diagnosis of Plasmodium and Babesia infections in a low prevalence setting (Journal of Clinical Microbiology) Notes from the Field: Rhodesiense Human African Trypanosomiasis (Sleeping Sickness) in a Traveler Returning from Zimbabwe — United States, August 2024 (CDC: MMWR) Miscellaneous The history of phage therapy LANCET: Infectious Diseases) Silence=death redux: infectious diseases, public health, and the imperative to resist (CID) Silence = Death, 1990(David Wojnarowicz Foundation) SILENCE=DEATH (B200KLYN Museaum) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

On episode #26 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/30 – 4/12/23. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Fatal rabies infection with failure of post-exposure prophylaxis following a zoonotic exposure (CID) Bivalent perfusion F vaccine in pregnancy to prevent RSV in infants (NEJM) Adeno-associated virus type 2 in US children with severe hepatitis (Nature) Genomic investigations of unexplained hepatitis in children (Nature) Antiretroviral treatment of HIV/AIDS during pregnancy (JAMA) Rapid PCR for respiratory viruses reduces time to result and improves clinical care (JOI) Postexposure doxycycline to prevent bacterial sexually transmitted infection (NEJM) Survey on antimicrobial resistance genes of used probiotic bacteria (EURO) Structured immune work-up in healthy children with episode of severe bacterial infection (JID) Antibiotic prescribing in U.S. nursing homes (JID) Syndromic panel testing among patients with infectious diarrhea (OFID)  Early predictors of infected pancreatic necrosis in severe pancreatitis (DD) Management of nontuberculous mycobacteria in lung transplant cases (ERJ) Impact of extended-infusion piperacillin-tazobactam (Infectious Medicine) Camber Pharmaceuticals issues nationwide recall of atovaquone oral suspension due to potential Bacillus cereus contamination (FDA) Cluster of Blastomycosis among neighborhood residents (CDC) Risk factors for late-onset Pneumocystis jirovecii pneumonia in liver transplant recipients (IJID) Hyponatremia predicts cryptococcal meningitis and mortality in HIV-Positive asymptomatic individuals with cryptococcal antigenemia (OFID) Investigation of donor-derived Strongyloides stercoralis infection in multiple solid organ transplant recipients (TID) Promising new malaria vaccine for kids approved in Ghana (AP) Music is by Ronald Jenkees

2022 was another exciting year in human origins research! New fossil discoveries and ancient DNA research expanded our understanding of the past. We learned something surprising about the evolution of human speech, and new methodologies and showed promising potential to improve the future of medicine. In this episode, four Leakey Foundation scientists shared their favorite human evolution discoveries from the past year. Our guests Carol Ward, University of Missouri Sofia Samper Carro, Australian National University Kevin Hatala, Chatham University Megan Henriquez, City University of New York Links to learn more Evolutionary loss of complexity in human vocal anatomy as an adaptation for speech When less is more in the evolution of language The face of the first European found in Atapuerca Europe's oldest fossil named after Pink Floyd Meet the first Neanderthal family Genetic insights into the social organization of Neanderthals Population genetics study of Strongyloides fuelleborni  The Leakey Foundation Origin Stories is a project of The Leakey Foundation, a nonprofit organization dedicated to advancing human origins research and outreach. Want to support the show? Your donation will be matched by Leakey Foundation President Jeanne Newman who is matching up to $5,000 in gifts from Origin Stories listeners. Every dollar helps! leakeyfoundation.org/originstories23 Sponsors and credits This episode was generously sponsored by Diana McSherry and Pat Poe. Origin Stories is also sponsored by Jeanne Newman, the Ann and Gordon Getty Foundation, Camilla and George Smith, and the Joan and Arnold Travis Education Fund. Thanks as well to the Benevity Community Impact Fund for their support of the show. Origin Stories is produced by Ray Pang. Our editor is Audrey Quinn. Theme music by Henry Nagle. Additional music by Blue Dot Sessions and Lee Roservere. Join us for these events February 8, 6 pm Pacific -  Where is the love?: Secrets of Chimpanzee Relationships - click to register February 16, 11 am Pacific - Lunch Break Science with Tom Plummer - click to watch

Today I am joined by Nicolas Barros, Assistant Professor of Clinical Medicine and Medical Director of Transplant Infectious Disease at Indiana University. We are discussing his background, Chagas, Strongyloides, and Peruvian soccer.

Mora Carpio AL, Meseeha M. Strongyloides Stercoralis. [Actualizado el 12 de agosto de 2021]. En: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 enero-. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK436024/ --- Send in a voice message: https://anchor.fm/las-poderosas-celulas-nk/message

Today we'll look at African swine fever in the Dominican Republic, Is the Delta variant deadlier?, Tularemia infection from crabs, Melioidosis in the US, Another Ebola outbreak and Strongyloides hyperinfection.

Crystal shares a story about the strongest worms in the world against the strongest women in the world and triumphs. --- Send in a voice message: https://anchor.fm/more-morgellons/message Support this podcast: https://anchor.fm/more-morgellons/support

Audun returns to help solve the case of the Ecuadorean Gentleman Treated for COVID-19, followed by a discussion of the interaction of Blastocystis with the intestinal microbiota and the immune system, and of course a new clinical case from Daniel. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Audun Lier Download TWiP #192 (46 MB .mp3, 76 minutes) Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter Blastocystis interactions with gut microbiota and immune system (PLoS Path) Hero: Lucy Engel Graves Taliaferro Letters read on TWiP 193 Become a patron of TWiP Case Study for TWiP 193 Male, 50s, seen by physician for unilateral eye pain, blurred vision, watery drainage. Soft contact lens wearer. Given eye drops, oral medication, sent for another opinion when does not resolve. Has hypertension, hyperlipidemia, no surgeries, no allergies, is on hypertension/statin med. Works in store. No toxic substance use. HIV negative. Lives on large piece of land with his own well, away from city, own septic tank. Left eye is very red. Ophthalmologist report: decreased visual acuity in left eye, injection of conjunctiva, edema, erosions, send corneal scrapings for culture. Swims in Long Island Sound. No travel history. No pets.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

In Part 2 of this "Mini Grand Rounds" series, we discuss hyperinfection syndrome and its treatment with ivermectin. Please click HERE to leave a review of the podcast!References:All references for Episode 40 and Episode 41 are found on my Read by QxMD collection

Crystal explores the likelihood that living in an endemic region and working in mental institutions makes strongyloides a likely suspect in the mysterious case of Morgellons. --- Send in a voice message: https://anchor.fm/more-morgellons/message Support this podcast: https://anchor.fm/more-morgellons/support

In Part 1 of this "Mini Grand Rounds" series, we discuss corticosteroid use in COVID as well as the pathogenesis of strongyloides. Please click HERE to leave a review of the podcast!References:All references for Episode 40 and Episode 41 are found on my Read by QxMD collection

This episode covers strongyloides stercoralis!

Richard Bradbury specializes in parasitic diseases in humans, particularly zoonotic parasites, which indicates they were transmitted through other animals.  He shares his vast knowledge of parasitology with listeners by discussing What are common parasitic diseases as well as less common human parasitic diseases still of concern, How he's focused on improving diagnostics as parasitic infection symptoms don't usually indicate the parasite type, and What areas are most vulnerable and how he's working to create systems to address this vulnerability. Richard Bradbury is a senior lecturer in the Clinical Microbiology and Molecular Biology Department at Federation University in Australia. His major focuses are on parasitology diagnostics and epidemiology; therefore, world health and prevention falls into his purview.  He's especially done a lot of work on the Pacific Islands with soil-transmitted helminths. He adds that because parasites are usually a problem with underserved populations, locating where parasites tend to congregate before infecting humans is important to his work. He offers listeners several examples of parasites and their habits to show their reach. In Australia, for example, they have a really big problem with the Strongyloides stercoralis worm. Human hosts can have infections decades later and they are still having trouble with Vietnam vets suffering from these infections from their time in Southeast Asia. The immune suppressed are especially vulnerable and may die from infection. He also discusses his efforts with communities who are isolated and have less access to medical care and prevention measures. These include groups from aboriginal communities in Australia to rural Mississippi populations. He addresses common testing techniques and relays his own involvement with developing a single universal parasite test that uses next-generation sequencing. He also discusses a variety of parasitic infection symptoms and global efforts towards prevention. Find out more by searching his name in google scholar and research gate and see his website at Federation University: federation.edu.au/schools/school-of-science-psychology-and-sport/staff-profiles/staff-directory/bradbury. Available on Apple Podcasts: apple.co/2Os0myK

SURPRISE! For Christmas you get a new episode a day early! Our Christmas Special is an ode to the NHS, and to all of the doctors, nurses, HCAs, porters and cleaners working hard over the festive period to keep us safe! As such, my guest this week is Robbie Hammond, a junior doctor working at Charing Cross Hospital. He'll be working a 13 hour shift on the big day so wishing him a very merry crimbo on the ward!

The parasitic roundworm Strongyloides stercoralis crawls through contaminated soil in search of one thing – human flesh. Often no more than a millimeter in size, it’s currently estimated to be hanging out in the intestines of over 300 million people worldwide. How it finds us has a lot to do with the chemicals we’re giving off. 

Justin joins the TWiP team to solve the case of the Gentleman with B cell Lymphoma, and consider the finding of Dracunculus species in river otters from Arkansas. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Justin Aaron Become a patron of TWiP. Links for this episode: Dracunculus in river otters (J Parasitol) Image credit Letters read on TWiP 155 Case Study for TWiP 155 Another challenging one. 60 yo man with poorly defined immunodeficiency: low Ig, low T cells, on chronic Ig therapy. Admitted with 1 yr chronic diarrhea. Had upper endoscopy, inflammation of duodenum, crypt hyperplasia, diffuse ulceration. Lower colonoscopy: granular appearance to cecal mucosa. Loss of haustral folds. Biopsies done and sent for culture. PMH: poorly understood interstitial lung disease. Unable to work, no toxic habits. Born Ecuador, moved to US in early 40s, living in Staten Island. No fever, bp low, hr >100, resp high teens. Remarkable: looks frail but not terribly ill. Labs: normal WBC, shifted to left with increase in neutrophils and eosinophils. Albumin low; respiratory pathogen positive for rhinovirus. Serum CMV: >4000 (virus measurement). Started on ivermectin, WBC rises, broad spectrum Ab. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

On today's show we discuss a most interesting parasite, the soil transmitted helminth, Strongyloides stercoralis. This parasite is more commonly found in areas that are relatively warm and moist, in rural areas, and areas associated with agricultural activity, but it can occur anywhere. Strongyloidiasis can be severe and life-threatening in persons who are immunosuppressed where forms of the disease called hyperinfection syndrome and disseminated strongyloidiasis can occur. Joining me is parasitology teacher and author of the book, Parasites: Tales of Humanity's Most Unwelcome Guests Rosemary Drisdelle.

On today’s show we discuss a most interesting parasite, the soil transmitted helminth, Strongyloides stercoralis. This parasite is more commonly found in areas that are relatively warm and moist, in rural areas, and areas associated with agricultural activity, but it can occur anywhere. Strongyloidiasis can be severe and life-threatening in persons who are immunosuppressed where forms of […] The post Strongyloides stercoralis: Severe and life-threatening infection in the immunosuppressed appeared first on Outbreak News Today.

The TWiP-tologists solve the case of the South American Child With Belly Pain, and reveal how B1 cell IgE blocks parasite clearance by inhibiting mast cell activation by B2 cell IgE. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Do not eat raw earthworms! (Pediatrics) Would you let worms in your veins? (Science) Guinea Pig Doctors by Jon Franklin and John Sutherland Parasite Hero: David Bruce Letters read on TWiP 148 Case Study for TWiP 148 Will have a guest on next show to unveil! Female teenager living in NYC, previously in good health, rash for 2 week, abnormal feeling in legs. Initially had URT infection, no cough or fever. Rash is itchy, worse at night. But feeling of pins and needles, sharp stabbing in feet and legs. In ER told is zoster, started on gabapentin. Few days later fevers, pain getting worse. Seen by neurologist and ID doc, admitted. No past med/surg. Type 1 diabetes in aunt, father migraines, no autoimmune diseases. Had received chickenpox vaccine! Social: lives with parents and younger brother, much travel, Holland, Hawaii, most recent, pet lizard. In Hawaii, salad that she ate but no one else. Physical: febrile, heart rate >110, bp ok. Does not want to move because of pain. Neurological: extremity movement is slow. Rash irregular on chest, neck, back, abdomen. Labs: white normal, not much shift. Sed: 24, slightly increased. Lumbar puncture: increased white cells 280, 32% eosinophils. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

El episodio de hoy se lo dedicamos a Strongyloides stercoralis. Revisamos algunos conceptos básicos de su epidemiologia, diagnostico y tratamiento y comentamos un articulo que arroja dudas sobre la eficacia a largo plazo del uso de ivermectina en el tratamiento de esta parasitosis.  Referencia:  Silvia A Repetto y colaboradores. Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up after Ivermectin Treatment. Clin Infect Dis. Jan 22. 2018   La Frase de la Semana:  Clive Staples Lewis (29 de noviembre de 1898 - 22 de noviembre de 1963) fue un novelista, poeta, académico, medievalista, crítico literario, ensayista, teólogo y locutor britanico Ocupó cargos académicos en la Universidad de Oxford y la Universidad de Cambridge . Es mejor conocido por sus obras de ficción, especialmente The Chronicles of Narnia y The Space Trilogy. La frase dice: “Ningún hombre conoce lo malo que es hasta que no ha tratado de esforzarse por ser bueno. Sólo podrás conocer la fuerza de un viento tratando de caminar contra él, no dejándote llevar.

Daniel and Vincent solve the case of the Haitian Girl Who Failed To Thrive, and visit two studies that address the question of whether infection with Toxoplasma gondii alters human behavior. Hosts: Vincent Racaniello and Daniel Griffin   Links for this episode: ASM Grant Writing Online Course Is Toxoplasma infection related to brain and behavior impairments? (PLoS One) Toxoplasma infection and sexual attraction (Evol Psychol) TWiP 21 - The giant intestinal worm, Ascaris lumbricoides Candiru (Wikipedia) Image credit Letters read on TWiP 134 Case Study for TWiP 134 Woman in 30s, coming in Colorado to be seen, reports foul smelling loose stools multiple times each day, cramping and nausea. Started a few weeks ago. No fever, summer, no unusual travel, skiing up in mountains, hiking, backpacking. Originally from NE, moved to Colorado one year before. Often drinks from streams. Treats water with iodine. On overnight trips pack food and cook on stoves. Sticky stools, trouble wiping clean. Yes, my stools do float. Color, not as dark. Well formed. No medical problems, no surgeries, no allergies. Takes no medications. Lives alone in private home. Drinks beer, no other toxic habits. None of her friends report similar problems. Sexually active, does not always use protection. Physical exam: unremarkable. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPerati solve the case of the Man Who Sat in Feces, and discuss a study on how Dickson's favorite parasite induces the formation of a collagen capsule. Become a patron of TWiP. Links for this episode: Induction of collagen synthesis by Trichinella (Vet Parasitol) Letters read on TWiP 128 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twip. Case Study for TWiP 128 Daniel doesn’t expect anyone to get this. From Australia, 80 yo retired teacher from Atherton, northheast Australia, presents to clinic with generalized weakness, concern of chronic lyme or Q fever. Seen by neurologist, concern about motor neuron disease. 18 months of illness, insidious onset of limb (arms and legs) weakness. No issues with speaking, swallowing or breathing; no weight loss; no fever, sweat, chill. History of osteoarthritis, joint replacements; myocarditis; vertigo; allergic to pen and dox. Father, rhematoid arthritis, brother colon cancer. On a number of medications. Does extensive travel, when not traveling, is a volunteer carer in Australia (abandoned wildlife), over the past three years. Lives with husband. Marsupials, hand feeds puggles and juvenile spiny anteaters, has pet cockatoo. No history of polio, HIV negative. Neuro exam: diffuse non tender muscle with no rash. Normal upper and lower limb tone, strength is symmetrically reduced proximally. Reflexes good at knees, normal sensation to all modalities. Normal cranial nerve exam. Test results: has eosinophilia, elevated muscle enzymes, EMG shows myopathic changes, nerve conduction normal. Stop statin therapy, no change. This is a rare parasite. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Imagine your name is Bob. You’re 47 years old, you have a beautiful wife, two wonderful kids, a lovely dog and a career you enjoy. Life is great is except for the nagging pain in your right pinky finger. It started as a minor irritation but now has gotten to the point where it’s affecting your work and your sleep. As you lay tossing and turning one night, all you can think about is the pain. Then suddenly you decide it’s time to get up and take action. You kiss your wife and sneak out the bedroom. The dog is confused and follows you downstairs and into the kitchen. You open up the lid of your laptop and open a new browser window. Google appears. What are you going to search for? Doctor [Your Name Here] Ultrawellness? Optimal Health Nutrition Coach? Of course not. You’re going to search for “right pinky finger pain” or some variation of those words. So why is then that so many practitioners, good ones, create websites that are all about themselves? You know the site I mean. The one with the picture of the practitioner on the front page, possibly wearing a white lab coat and a stethoscope around their neck. There’s a list of credentials and a longer list of health complaints the practitioner "specialises" in. The list includes virtually every condition known to man. Think about Bob reading that page. Is he going to be excited? Now imagine Bob’s delight as he discovers your series of articles talking about the most common root causes of right pinky finger pain and what you can do about them. Bob is so delighted with what he’s found that he wants to wake his wife to share the good news. "Finally! Someone that understands me" is what Bob is thinking. Being specific about who we’re talking to is something we’ve done by accident at Nourish Balance Thrive. I’m a master’s athlete whose health fell apart in pursuit of the upgrade to pro mountain biker racer. Not everyone we work with is a mountain biker, but everyone is an athlete (even if they won’t admit it). Starting a new health coaching business is about more than being a great practitioner. Of course, you must be qualified to help people, but if you’re not specific with your marketing, you’ll end up helping nobody. You only have to walk down the street anywhere in the US to recognise how many people need help with their diet and lifestyle, but did you know that 50% of naturopaths never see a patient? 60% of acupuncturists go back to a previous career after less than three years of work? And yet at the same time, as of last year, there were three billion people online, and we know that there's another three billion people that are coming in the next five years or so depending on what study you read. There is no shortage of people that need your help. This is but one of the many lessons I’ve learned as a result of completing the Practitioner Liberation Project. Listen to this interview with gut health guru and marketing conversion expert Jordan Reasoner to discover some of the others. Click here to sign up for Jordan’s webinar. Here’s the outline of this interview with Jordan Reasoner 0:02:12    Jordan's story. 0:03:44    Book: Breaking the Vicious Cycle: Intestinal Health Through Diet. 0:04:48    Jordan had a parasite called Strongyloides stercoralis and took a medicine called Ivermectin. 0:05:37    SCD Lifestyle will become healthygut.com 0:05:56    Their list now has 250,000 members. 0:08:14    We both did the Kalish Mentorship. 0:08:33    One email, Jordan and Steve were booked out for a month, 600 clients in the next year. 0:09:32    The gut wizard: Brie Wieselman, L.Ac. 0:13:44    50% of naturopaths never see a patient 0:13:49    60% of acupuncturists go back to a previous career within three years. 0:25:41    1.5M people in the US alone with Rheumatoid arthritis. 0:26:14    1.7B people on Facebook. 0:29:53    Start with the thing that you're passionate about. 0:32:38    Ask yourself who you want to work with. 0:38:10    500 practitioners in the PLP. 0:45:57    WeScribeIt. 0:46:47    The Essential Keto Cookbook. 0:49:33    Business supports systems.

In der vorliegenden Arbeit wurden insgesamt 497 Patienten mit mikroskopisch gesicherten Helminthiasen hinsichtlich epidemiologischer und klinischer Daten sowie auf indirekte Laborparameter (Eosinophilie und Gesamt-IgE-Erhöhung) und die Resultate immundiagnostischer Verfahren untersucht. Hierbei wurden die Ergebnisse von 329 Reiserückkehrern und 168 Migranten mit jeweils 8 Diagnosen (Ankylostomiasis, Askariasis, Fasziolose, Filariose, Schistosomiasis, Trichinose, Trichuriasis, Mischinfektionen) miteinander verglichen. Für die Evaluation der immundiagnostischen Verfahren wurden vorhandene Seren mit 9 Antigenen (Schistosoma mansoni, Onchocerca volvulus, Dirofilaria imitis, Trichinella spiralis, Fasciola hepatica, Toxocara canis, Strongyloides ratti, Ascaris lumbricoides, Ascaris suum) getestet. Vorbestehende Ergebnisse aus der Routinediagnostik wurden mit einbezogen. Als Kontrollen dienten die Seren von 80 gesunden Personen ohne Hinweise auf eine Wurmerkrankung in der Vorgeschichte und ohne einen vorherigen Aufenthalt in den Tropen oder Subtropen. Die epidemiologischen Daten zeigen eine eindeutige Zuordnung von Schistosomiasis und Filariosen auf den afrikanischen Kontinent, während die Geohelminthiasen (Erkrankungen durch Helminthen, deren präadulte Stadien sich im Erdboden entwickeln und die eine reise- bzw. migationsmedizinisch wichtige Bedeutung haben) von den Reiserückkehrern vorwiegend in Asien, vorzugsweise in Südostasien, akquiriert wurden. Die Migranten stammten hauptanteilig aus Afrika, es waren dennoch alle wesentlichen tropischen und subtropischen Gebiete vertreten. Die Auswertung der klinischen Symptomatik zeigte ein klares Erscheinungsbild der Filariosen mit Hauterscheinungen und Juckreiz sowie die überdurchschnittlich häufige Angabe von Harnwegsbeschwerden bei Infektionen mit Schistosoma haematobium. Bei allen Geohelminthosen und Infektionen mit Schistosoma mansoni herrschte bei den Reiserückkehrern eine gastrointestinale Symptomatik vor, während die Migranten insgesamt mehr unspezifische Beschwerden aufwiesen. Circa ein Drittel der Patienten war asymptomatisch. Die Sensitivität der Eosinophilie als indirekter Parameter lag in dieser Arbeit für Wurmerkrankungen im Allgemeinen bei 45%, variierte aber von Diagnose zu Diagnose erheblich, wobei kein signifikanter Unterschied zwischen Reiserückkehrern und Migranten zu finden war. Eine Hypereosinophilie fand sich überdurchschnittlich häufig bei Migranten mit Filariose und bei Reiserückkehrern mit Strongyloidiasis; die Patienten mit Askariasis und Trichuriasis zeigten dagegen kaum Abweichungen von der Kontrollgruppe. Eine Gesamt-IgE-Erhöhung fand sich insgesamt bei 43% der Patienten, wobei es einen signifikanten Unterschied zwischen Reiserückkehrern (25%) und Migranten (75%) gab. Besonders hohe IgE-Serumspiegel konnten bei Migranten mit Schistosomiasis, Strongyloidiasis und Ankylostomiasis gefunden werden. Davon abweichend waren allerdings die Resultate von Reiserückkehrern mit Mischinfektionen. Bei diesen Patienten konnte eine unerwartet häufige Gesamt-IgE-Erhöhung verzeichnet werden (75%). Die serologischen Untersuchungen zeigten zumeist eine gute Sensitivität, aber erhebliche Kreuzreaktionen mit verwandten und nicht verwandten Wurmarten, sodass eine Differenzierung nur für die Schistosomiasis und die Filariosen valide gewährleistet ist. Der im Rahmen dieser Arbeit entwickelte Ascaris suum-ELISA, ergab eine Sensitivität von 60% und eine Spezifität von 90% und hat in der Routinediagnostik eine gewisse Berechtigung, da der Ascaris lumbricoides-ELISA inakzeptable Ergebnisse erbrachte. Zusammengefasst stellt die Eosinophilie einen wichtigen hinweisenden Parameter auf eine Wurminfektion dar, ist aber keine ausreichende Screeningmethode bei Rückkehr aus Endemiegebieten. Die serologischen Untersuchungen ergaben eine sinnvolle diagnostische Ergänzung bei der Schistosomiasis und den Filariosen. Eine Differenzierung der Geohelminthosen ist weiterhin nur durch direkte Nachweismethoden, wie z. B. dem Ei- bzw. Larvennachweis im Stuhl oder in einem Körpergewebe, verlässlich möglich.

Vincent and Dickson discuss five ways that helminths manipulate host tissues to survive. Hosts: Vincent Racaniello and Dickson Despommier Links for this episode: Wormholes in host defense (PLoS Path) Lung coin lesion (Wikipedia) Granuloma (Wikipedia) Jar that Dickson is holding (jpg) Letters read on TWiP 72 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review the finding that urocanic acid in the skin is a chemoattractant for the parasitic nematode Strongyloides stercoralis. Download TWiP #71 (60 MB .mp3, 84 minutes). Links for this episode: Strongyloides stercoralis (TWiP #71) Urocanic acid is a S. stercoralis chemoattractant (PNAS) Chemical trails of parasites (PNAS) Urocanic acid (Wikipedia) Candiru (Wikipedia) Your Inner Fish (PBS) Letters read on TWiP 71 Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Thu, 3 May 2012 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/14313/ https://edoc.ub.uni-muenchen.de/14313/1/Pompl_Moritz.pdf Pompl, Moritz ddc:610, ddc:600, Mediz

Vincent and Dickson review the life cycle and pathogenesis of the world's most unusual parasite, Strongyloides stercoralis.