Podcast appearances and mentions of james priest

James Priest of The Referend interviews Marika Josephson of Scratch Brewing.For original articles or to read the vast archives or to check out All About Beer.  follow us on X @allaboutbeer and Instagram @allaboutbeer. Support Journalism by visiting our Patreon Page.This Episode is Sponsored by:Firsd TeaOsmanthus radiates fresh floral Spring like no other flower. Add osmanthus to lambics, lagers, pilsners, witbiers, or other Belgian styles. Firsd Tea is your source for osmanthus and teas that fit the unique flavor profiles you're looking for. Email info@firsdtea.com to discover the perfect teas and botanicals for your next project.Beer Law CenterFor more than a decade The Beer Law Center has been dedicated to the craft beverage industry, meeting the legal needs of breweries, wineries, distilleries, and all manner of alcohol producers and sellers around the country. From company formation to federal and state licensing, trademarks, regulations, and compliance or if you are buying or selling an alcohol business, the Beer Law Center should be your first call.  The firm never charges for an initial consultation and if they can't help you, they'll help you find someone that can.Have a legal question? Contact the Beer Law Center. On social media @beerlawcenter and online at beerlawcenter.com.Malteurop Malting CompanyMalteurop Malting Company (MMC) is based in North America—specializing in growing and producing quality malts for the craft beer and distilling industries. With local farms and Malthouses spread across the United States, Canada, and Mexico, MMC's commitment to excellence is fully ingrained into every batch it produces, ensuring breweries and distilleries of any size can create the finest beverages on the planet. Visit www.malteuropmaltingco.com to learn how MMC can support your malting needs. Contact MMC at customersuccess@malteurop.com or (844) 546-MALT (6258) for questions or to place your order.Iron Heart CanningIron Heart Canning is the quality leader in mobile canning and much more. With a decade of packaging experience, Iron Heart is your turnkey solution for your all your canning needs. Are you looking for a unique can size or nitro dosing? Iron Heart offers filling sizes from 6oz up to 19.2, dedicated equipment for mixed culture products and nitro dosing capabilities for still beverages and beer. Looking to break into other beverage segments? Look no further, Iron Heart also provides a robust network of co-packing solutions to get a variety of beverages in cans both alcoholic and non-alcoholic alike. Iron Heart Canning. You have the capability because Iron Heart can do it for you. Visit them at IronHeartCanning.com or email at info@ironheartcanning.com.Host: James PriestGuest:  Marika JosephsonSponsor: Firsd Tea, All About BeerTags: Brewing, Illinois, Spontaneous, Ingredients, Community, EquipmentPhoto Credits: Demond Meek and Tom Frenchu.The following music was used for this media project:Music: Hip Hop Intro 06 by TaigaSoundProdFree download: https://filmmusic.io/song/9533-hip-hop-intro-06License (CC BY 4.0): https://filmmusic.io/standard-licenseArtist website: https://linktr.ee/taigasoundprod ★ Support this podcast on Patreon ★

Alex Helms of Troon Brewing interviews James Priest of The Referend.For original articles or to read the vast archives or to check out All About Beer.  follow us on X @allaboutbeer and Instagram @allaboutbeer. Support Journalism by visiting our Patreon Page.This Episode is Sponsored by:Firsd TeaOsmanthus radiates fresh floral Spring like no other flower. Add osmanthus to lambics, lagers, pilsners, witbiers, or other Belgian styles. Firsd Tea is your source for osmanthus and teas that fit the unique flavor profiles you're looking for. Email info@firsdtea.com to discover the perfect teas and botanicals for your next project.Beer Law CenterFor more than a decade The Beer Law Center has been dedicated to the craft beverage industry, meeting the legal needs of breweries, wineries, distilleries, and all manner of alcohol producers and sellers around the country. From company formation to federal and state licensing, trademarks, regulations, and compliance or if you are buying or selling an alcohol business, the Beer Law Center should be your first call.  The firm never charges for an initial consultation and if they can't help you, they'll help you find someone that can.Have a legal question? Contact the Beer Law Center. On social media @beerlawcenter and online at beerlawcenter.com.Malteurop Malting CompanyMalteurop Malting Company (MMC) is based in North America—specializing in growing and producing quality malts for the craft beer and distilling industries. With local farms and Malthouses spread across the United States, Canada, and Mexico, MMC's commitment to excellence is fully ingrained into every batch it produces, ensuring breweries and distilleries of any size can create the finest beverages on the planet. Visit www.malteuropmaltingco.com to learn how MMC can support your malting needs. Contact MMC at customersuccess@malteurop.com or (844) 546-MALT (6258) for questions or to place your order.Iron Heart CanningIron Heart Canning is the quality leader in mobile canning and much more. With a decade of packaging experience, Iron Heart is your turnkey solution for your all your canning needs. Are you looking for a unique can size or nitro dosing? Iron Heart offers filling sizes from 6oz up to 19.2, dedicated equipment for mixed culture products and nitro dosing capabilities for still beverages and beer. Looking to break into other beverage segments? Look no further, Iron Heart also provides a robust network of co-packing solutions to get a variety of beverages in cans both alcoholic and non-alcoholic alike. Iron Heart Canning. You have the capability because Iron Heart can do it for you. Visit them at IronHeartCanning.com or email at info@ironheartcanning.com.Host: Alex HelmsGuest:  James PriestSponsor: Firsd Tea, All About BeerTags: Brewing, New Jersey, Spontaneous, IPA, MovingThe following music was used for this media project:Music: Hip Hop Intro 06 by TaigaSoundProdFree download: https://filmmusic.io/song/9533-hip-hop-intro-06License (CC BY 4.0): https://filmmusic.io/standard-licenseArtist website: https://linktr.ee/taigasoundprod ★ Support this podcast on Patreon ★

Heute zu Gast: Florian Zapp, Geschäftsführer der Storylines GmbH in Hamburg und Host des Podcasts systemisch - agil. Wir reden darüber, welche Fallstricke aus Sicht der Systemtheorie der Agilität das Leben schwer machen. Unsere drei großen Themenblöcke sind 1) Hierarchie und Macht 2) Mindset 3) Konflikte Links: Florian Zapp: https://www.linkedin.com/in/florian-zapp-384876202/ Storylines Hamburg: https://www.storylines.hamburg Systemisch agil: https://systemisch-agil.podigee.io Interview mit James Priest: https://open.spotify.com/episode/1KV7hagSSW1yuuboWnOzm4?si=cee4a532247541ba Der Zweck von Hierarchie: https://open.spotify.com/episode/5oUtj8j0v7PpuLulR6ft1Z?si=6551a43be16345e3 Literatur: - Jo Freeman: Die Tyrannei der unstrukturierten Gruppe https://www.anarchismus.at/anarcha-feminismus/feminismus/807-joreen-die-tyrannei-der-unstrukturierten-gruppen - Why agile mindset matters https://www.sciencedirect.com/science/article/pii/S0040162522001822 - Fritz B.Simon Einführung in die systemische Organisationstheorie - Klaus Eidenschink: Die Kunst des Konfliktes Martin Aigner: Twitter: @aigner_martin LinkedIn: https://www.linkedin.com/in/martin-aigner-865064193 David Symhoven: LinkedIn: https://www.linkedin.com/in/david-symhoven-2a04021a5/

Welcome to the Living Room Conversations by LIVEsciences! Our guest, James Priest, is the co-founder and learning facilitator at Sociocracy 3.0 Academy. He currently spends most of his time helping people to get the best out of S3. Besides development and delivery of courses and learning journeys, he works directly with people in organizations across many sectors to help them improve productivity and engagement, increase business agility and grow resilient learning organizations where people and company thrive. We have seen the catalytic power of conversations in the work that we do, as well as the impact that it brings to our world. Our Living Room is a space for us to connect, to explore thoughts and learnings, in a relaxed and very human way. Through this channel, we look forward to an engaging dialogue and resonance with our guests, and bring a breath of fresh air to the space we occupy in this virtual world. To our listeners and followers, we hope to create an opportunity to candidly eavesdrop and chime in to one of the many interesting conversations around the space of teal, agile and the future of work. Stay tuned for our next Living Room Conversations.

Episode 437 - James Priest, the Referend Bier Blendery Happy Labor Day, Thieves! We've got a return guest this week in James Priest of the Referend Bier Blendery. The last time we spoke, James was a NJ-based mobile coolship haulin' brewery. He's since set up a permanent shop in Pennsylvania but is still making the same 100% spontaneously fermented beers. We catch up and talk some NJ/PA politics while sipping some seasonals from the black glass. Tune in and let us know what you think!***As always, you can email your questions, complaints, whimpers, or whines to us at stealthisbeerpodcast@gmail.com. We read everything we get and we'll try to respond as quickly as we can. If not online, then on air. And THANKS! You can subscribe to STB on iTunes and PLEASE LEAVE US A REVIEW!!! Co-hosts: Augie Carton & John Holl Producer: Justin Kennedy Engineer: Brian Casse Music: "Abstract Concepts - What Up in the Streets" by Black Ant.

> Sign Up For Our Newsletter: http://www.firsthuman.com/being-human-newsletter/   This week's Being Human episode is with James Priest, exploring Sociocracy 3.0, the liberating approach to business based on the consent, not consensus, process. James combines extensive experience in sociocracy with 15 years of practice in the fields of holistic organizational development, facilitative leadership and personal and relational transformation across a variety of sectors, from corporations to non-profits, children and communities. We talk: Becoming a leader of a spiritual community at 27 First forays in using Sociocracy Preventing teenage pregnancies Developing Sociocracy 3.0 for use in business The unexamined drivers of our behaviour Links: Sociocracy 3.0

In a wild and spontaneous episode (see what we did there?), we are joined by Co-Owner of The Referend Bier Blendery, James Priest. Specializing in spontaneous fermentation and blending, The Referend opened in Pennington, New Jersey in 2016 and relocated to Pinnacle Farms in Kutztown, PA in 2021. We take a dive into the world of traditional, wild fermentation and the craft that goes into it, as well as some risks and pitfalls. Other topics include aroma terroir, barn cats, and Ethan Buckman. In Happy Fun Time, we played a round of There's Weird in My Beer featuring all brews from Earthbound Brewing in St. Louis, Missouri. Grab a mug of warm goodness and settle in to learn about the stewarding of wild little bugs that work hard so we can have such complex, delicious beer. Do you love Beer Busters? Of course you do!Why not leave us a rating and review on your podcast platform of choice and consider supporting us on Patreon.

ITS THE WILDWORLD EPISODE, AND BOY DID OUR BOYS WORK IT.  This weeks episode is a hodgepodge of different interviews with booze luminaries about what beverages inspired them. Duck keeps calling it bricolage, but fuck that guy. Thank you to our guests: Alice Jun from Hana Makgeoli, Andy Brennan from Aaron Burr,  Cooper Anderson from Austin Winery,  Nika Carlson from Greenpoint Cidery, and James Priest and Amy Rodriguez from the Referend Bier Blendery. Thank you SO MUCH TO THE WILD WORLD FESTIVAL and our Temporary studio at OTTRA  luxury furniture.  ////LIST////Aaron Burr Cidery, Bachinette, 2020//American Wine Project, Marquette, ‘Glacier's Edge Gardens,' 2021//Alta Marfa Wines, Robert Clay Vineyards Tempranillo, ‘Sobrino,' NV///Austin Winery,  Piquette, NV//Pipe and Tabor Coffee Roasters,  Santa Cruz Ozolotopec, Mexico ////Support the show (https://www.patreon.com/Disgorgeous)

Smashing out a couple of recent Aussie classics this week with Rhys Hope and James Priest from Sydney based indie-rock band Highline! Tame Impala's debut 'Innerspeaker' is up against DMA's debut 'Hills End' ~ singles and hits galore on these two. Enjoy!

ist ein Methodenkoffer, der dir und vor allem Organisationen dabei hilft, Komplexität zu meistern. Einer der zentralen Aussagen, die für David S3 beschreiben ist "An der Schnittstelle zwischen dem Gewohnten und dem Neuen liegt das Potenzial für ein größeres Bewusstsein". Vielleicht ergibt dieser Satz erstmal keinen Sinn für dich und das ist ok. Da kann man schonmal eine Weile drüber nachdenken und James Antwort hilft dir bestimmt schon ein Stück weiter. Aber was macht denn S3 jetzt so besonders? Nun ja, anstatt einem fest vorgegebenen Rezept zu folgen, hat James mit seiner Frau Lily David und seinem Freund Bernhard Bockelbrink die Strukturen hinter den erfolgreichsten Methoden wie Scrum, Kanban oder auch Holocracy extrahiert. Und das Ergebnis dieser Arbeit ist eine Reihe von Verhaltensmustern, die weit über den Zeitrahmen, seit es S3 gibt, hinausreichen und bereits von vielen verschiedenen Organisationen in aller Welt erfolgreich benutzt werden. Was James als eines der wichtigsten Verhaltensmuster erachtet und wie du anfangen kannst S3 gleich morgen für dich zu nutzen, das erfährst du in der heutigen Folge! Danke, dass du diese Woche wieder dabei bist! Wenn du mehr über S3 erfahren möchtest oder sogar spezielle Themenwünsche hast, dann schreibe uns gerne an podcast@wir-muessen-reden.net. For more information about Sociocracy 3.0, you can check out the official website: https://sociocracy30.org/ To explore the Sociocracy 3.0 Practical Guide in English: https://patterns.sociocracy30.org/ To explore the Sociocracy 3.0 Practical Guide in Deutch: https://patterns-de.sociocracy30.org/ For opportunities to learn more about Sociocracy 3.0: https://www.learnsociocracy30.org And to join the Sociocracy 3.0 Online Learning Community: https://community.sociocracy30.org/ For James' personal website, check out Thrive-in Collaboration: https://www.thriveincollaboration.com

The Referend Bier Blendery uses its own mobile coolship and other people's breweries to create spontaneously fermented beers. In this episode, founder James Priest talks about process, pitfalls, and working in the elements and his relationship with farmers to secure the best produce possible. From pre-acidification methods, to using the right wood, Priest dives into his methodology. This episode is brought to you by: G&D Chillers (https://gdchillers.com): As the brewing industry’s premier choice for glycol chilling, G&D Chillers has set the standard on quality, service, reliability and dedication to their customer’s craft. For 25 years G&D has led the way with innovative solutions for the craft brewing industry. Contact G&D Chillers today at 800.555.0973 or reach out online at Gdchillers.com. Mention Craft Beer and Brewing podcast and you’ll receive up to $1000 worth of glycol with the purchase of any new G&D chiller unit. Tavour (https://about.tavour.com): Tavour is the tastiest way to explore the world from the comfort of your home. Select delicious craft beers on the Tavour app that you cannot find in your area and get them delivered right to your door. It's not a beer of the month club where you end up with lagers you have to give to your grandpa. Download the free Tavour app today and get $10 in beer money with code “brewing”. Clarion Lubricants (https://www.clarionlubricants.com): Clarion Lubricants, balancing barley and hops is your expertise, food-grade lubricants is ours. The team at Clarion knows that when it comes to making great beer, you’re the expert, and when it comes to supplying food-grade lubricants backed by service-oriented professionals, they're the experts. Clarion will work with you to create an efficient lubrication program that helps protect your brewery. To speak with an expert dial 1-855-MY-CLARION (855-692-5274) or visit clarionlubricants.com. Clarion Lubricants. The expert that experts trust. Hops Direct (https://hopsdirect.com): Five generations of hops grown in Yakima Valley, Washington, sold directly from our farm to you. Skip the middleman, go for the farm fresh green! Our hops are harvested, processed and kept in cold storages here on our farm until shipping straight to you. Find 100+ domestic and imported varieties in Pellet and Leaf year-round on our website by the pound at wholesale pricing. Thanks for supporting family-owned - shopping small is a BIG deal. www.hopsdirect.com | info@hopsdirect.com | @hopsdirect

Dr Carolyn Lam:                Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the Journal and its editors. I'm Dr Carolyn Lam, associate editor from the National Heart Center in Duke National University of Singapore. Dr Greg Hundley:             And I'm Greg Hundley, also associate editor of Circulation and director of the Poly Heart Center at BCU Health in Richmond. Carolyn, we've got a really exciting interview to follow our coffee chat and it's evaluating individuals with low complexity congenital heart disease. We often think of those with high complexity congenital heart disease and looking at their cardiovascular events. We're going to hear a little bit about low complexity congenital heart disease.                                                 Now you've got a paper you wanted to talk about first. Dr Carolyn Lam:                Absolutely. You've got to hang on for that because I'm going to delve into chromatin architecture in heart failure, and it's in this paper from corresponding author Dr Foo from Genome Institute of Singapore.                                                 So, as background, the human genome actually folds in 3D to form thousands of chromatin loops within the nucleus encasing the genes and assists regulatory elements for accurate gene expression control. Now, these physical tethers of loops are anchored by the DNA binding protein CTCF, also known as the weaver of the genome and the cohesion ring complex. Now, the role of CTC in binding and changes in chromatin structure in heart failure are not well understood. Well, until today's paper.                                                 What the author said is they undertook an independent analysis of chromatin organization with mouse pressure overload model of myocardial stress or transverse aortic constriction, and a cardiomyocyte specific knockout of CTCF. So, interestingly, they found that the cardiac chromatin architectural in adult terminally differentiated cardiomyocytes was unchanged in pressure overload from transverse aortic constriction. Now this was completely unlike the CTCF knockout model where they verified that there was generation of vast genome-wide loss of genomic insulation and near complete abolition of the CTCF chromatin loops.                                                 Instead of chromatin rewiring on the scale of that knockout, the myocardial stress response appeared to proceed through enhancer H3K27 acetylation epigenetic changes and gene network co-regulation driven largely by fixed cardiac 3D chromatin architecture. In other words, a stable chromatin architecture really set the stage for accurate enhancer promoter interactions required for basal gene expression control and induction of the classical myocardial stress gene response. Dr Greg Hundley:             So Carolyn, are there therapeutic implications here for this? Dr Carolyn Lam:                Now of course, that was preclinical work, but it really opens the door to consider these epigenetic regulators that control disease expression changes and interacting gene sets in heart as potential future targets for novel heart failure therapy. Dr Greg Hundley:             Very interesting. So, I'm going to review and switch gears a little bit and focus on diabetic cardiomyopathy and mitochondria associated endoplasmic reticulin membranes. And this paper is from Shengnan Wu from the Center for Molecular and Translational Medicine at Georgia State University here in the US in Atlanta, Georgia. So as we all know, mitochondria are essential for cellular energy production, but when they're damaged, they become a major source of reactive oxygen species and pro-apoptotic factors. In particular, increasing evidence suggests that mitochondrial dysfunction is a central event in diabetic cardiomyopathy.                                                 Well, the mitochondria and the endoplasmic reticulum are key players that regulate many cellular functions and their structural and functional interactions are essential for cellular homeostasis. The contact points, however, through which the endoplasmic reticulum communicates with mitochondria, they're known as mitochondria associated endoplasmic reticulum membranes, or MAMS. Importantly, MAMS play a pivotal role in calcium signaling, lipid transport, energy metabolism and cell survival, and they've been implicated in a variety of diseases, including Alzheimer's Disease, cancer, lysosomal storage diseases, diabetes, obesity induced mitochondrial dysfunction and other metabolic disorders.                                                 But the role of these MAMS in the initiation and progression of Diabetic Cardiomyopathy is really unknown. So now, FUNDC1 is a highly conserved protein that's exclusively localized to the mitochondria. And this group had previously demonstrated that FUNDC1 was essential for maintaining the structure of MAMS and ensuring appropriate calcium transfer from the endoplasmic reticulum to the mitochondria normal hearts. Moreover, cardiac specific deletion of FUNDC1 induced cardiac dysfunction by inhibiting MAM formation. Dr Carolyn Lam:                Interesting. So that was their prior work? What did the current study show? Dr Greg Hundley:             Right, so what the investigator showed in this study is that high glucose driven inactivation of AMP-activated protein kinase increased FUNDC1 stability, but resulted in aberrant MAM formation, impaired mitochondrial calcium increase, mitochondria dysfunction and then cardiac dysfunction. And additionally, AMP-K activation reverses Diabetic Cardiomyopathy by suppressing high glucose induced MAM formation, mitochondrial calcium increase and mitochondrial dysfunction.                                                 And interestingly, Metformin, an AMP-K activator, used exclusively for Type 2 Diabetes, might be effective in treating Diabetic Cardiomyopathy in individuals with Type 1 Diabetes. So a very interesting mechanistic study providing some information of how MAMS, mitochondrial function and endoplasmic reticulum could be important in understanding how to prevent Diabetic Cardiomyopathy. Dr Carolyn Lam:                Indeed. And you know, that last note that you made on Type 1 Diabetes, also links very well with the next paper that I chose. Which really asks the question, in Type 1 Diabetes, what are the relative prognostic importance and optimal levels of risk factors for mortality and cardiovascular outcomes? And this comes from Dr Rawshani and colleagues from the Swedish National Diabetes register who studied more than 32,600 patients with Type 1 Diabetes in their national observational cohort study from the Swedish National Diabetes register, with a mean follow-up of 10.4 years and a mean duration of diabetes of 17.9 years.                                                 They found that the most important predictors for outcomes were HP-A1C, albuminuria, duration of diabetes, systolic blood pressure and low-density lipoprotein cholesterol, or LDL cholesterol. Now, the lower levels of HP-A1C, systolic blood pressure and LDL cholesterol than contemporary target levels were associated with lower risk for outcomes. Albuminuria was associated with a two to four times greater risk of cardiovascular disease and death. And each millimole increase of LDL cholesterol was associated with 35 to 50% higher risk for outcomes. Dr Greg Hundley:             Boy, Carolyn, those are interesting results. So, what do we take away from this in clinical management of patients? Dr Carolyn Lam:                The take home message is that in patients with Type 1 Diabetes, the strongest predictors for mortality and cardiovascular disease, with the exception of age, were mostly conventional and modifiable cardio-metabolic risk factors. And this in turn suggests that increased clinical focus on these risk factors, particularly in primary prevention, may result in the largest relative risk reduction for mortality and cardiovascular disease, even in Type 1 Diabetes. So, future clinical trials may be designed to test these findings. Dr Greg Hundley:             Very good. Well, Carolyn, my next paper, I'm going to talk about five year outcomes after off-pump versus on-pump coronary artery bypass grafting in those over the age of 75 years. And this paper comes from Anno Diegeler from Bad Neustadt in Germany. From June of 2008 to September of 2011, they evaluated a total of 2,539 patients that were 75 years or older, who had been randomly assigned to undergo off-pump or on-pump coronary artery bypass grafting across 12 centers in Germany.                                                 And the primary outcome was all cause mortality at five years, and the secondary outcome included a composite of death, myocardial infarction and repeat revascularization. What did they show in this study? Well, after a median follow up of five years, the hazard ratio for off-pump versus on-pump coronary artery bypass grafting was 1.03, confidence interval 0.81 to 1.19, no difference. The composite outcome of death, myocardial infarction and repeat revascularization, the same. Hazard ratio 1.03, confidence interval 0.89 to 1.18, P-value 0.7.                                                 So, first take-home message, no difference if you had your surgery off-pump or on-pump, if you're over the age of 75. Now, another outcome related to incomplete revascularization. And what was striking I this study is whether you underwent on-pump or off-pump bypass, if you were incompletely revascularized, that was associated with both the primary as well as the secondary outcomes. So, in elderly patients, in summary, greater than or equal to 75 years, the five year survival rates as well as the combined outcome of death, MI and repeat revascularization, was similar for on-pump versus off-pump CABG. And incomplete revascularization was associated with a lower five year survival rate, irrespective of the type of surgery that was performed. Dr Carolyn Lam:                Interesting. Beautifully summarized, Greg. Thank you. Dr Greg Hundley:             Absolutely. And let's head on to that featured article.                                                 Well, welcome everyone to the second half of our program. We are very excited today to have Dr James Priest, from Stanford University School of Medicine. And also our associate editor Gerald Greil from University of Texas Southwestern School of Medicine in Dallas. And we're going to be discussing the article, Substantial Cardiovascular Morbidity in Adults with Lower Complexity Cardiovascular Disease.                                                 So, James, first could you tell us a little bit about what constitutes low complexity congenital heart disease? And then a little bit about your study population, your design, and the results that you found with your study? Dr James Priest:                So, low complexity congenital heart disease really derives from definitions of congenital heart disease in adults that are grown up and have different complexity of lesions. And so high complexity congenital heart disease, you see things that, as people may remember, adult cardiologists may remember from their training. People remember from medical school, things like single ventricle disease, hypoplastic left heart, tetralogy of fallot, transposition of the great arteries. But, non-complex, so our low complexity disease, really constitutes a relatively simple malformation. Things like atrial septal defects, ventricular septal defects, patent ductus arteriosus. Things that are treatable with a single surgery.                                                 You close the hole, you ligate the vessels, you dilate the valve, and the patient is affectively cured. So relatively low complexity diseases that can be treated with typically, a single surgery or minimal interventions to restore completely, or essentially normal, cardiovascular physiology.                                                 So, the study was based upon a very large you know, volunteer data set, the UK Biobank. It comes from the United Kingdom where 500 thousand individuals enrolled, and from those individuals there is genetic information, medical histories dating back to the 1990s, self-reported history. A variety of functional and neuropsychiatric measures. And if you get a group of 500 thousand individuals from anywhere, there's going to be some congenital heart disease in there. And so, we looked to see what types of congenital heart disease were in there. And in fact, there was lower complexity individuals.                                                 And because I spent some time on the research side of things with my adult colleagues, the first thing we looked at were from the common adult cardiovascular outcomes, things people write about in Circulation all the time. Coronary artery disease, atrial fibrillation, heart failure. We know these things are problems in adults with complex cardiovascular disease, but nobody had really looked for the most part in adults with low complexity or non-complex disease. And we were surprised to see such high event rates for these common adult cardiovascular conditions. Dr Greg Hundley:             So, what type of events did you appreciate in the population in follow up? Dr James Priest:                So, we really appreciated about a two-fold rate of let's say, acute coronary syndrome relative to the general population. Up to almost 13 fold risk of atrial fibrillation and heart failure, relative to the general population. So, really substantial and very impactful event rates. Dr Greg Hundley:             Very good. And so, just a couple points of clarification. Do you think that the events you observed, were they related to the congenital heart disease, per se? Or could it have been a result from the surgical procedure to treat that heart disease? Dr James Priest:                So, that's a great question. I think, in some ways, that's the fundamental question that the paper leads to. So, we thought of it in two different ways. You know, one, were these events, and they're perioperative events, for individuals receiving some type of care for their congenital heart disease, during their adulthood? And we performed a sensitivity analysis where we basically looked at those events and then looked for events occurring within a year of adult interventions. And we saw no difference in those event rates. So, they weren't perioperative or postoperative events in adults receiving adult congenital heart disease care.                                                 The second part of the question is really more of an existential question in some ways. You know, is there some fundamental relationship between the care these people received as children? Or the genetic basis of congenital heart disease in the first place that is somehow put people at risk long term for adult cardiovascular disease, acquired adult cardiovascular disease? And I think there's indeed a lot of different ways to try and get at that question and explore that more, which we're currently working on. Dr Greg Hundley:             So, Gerald, I wanted to turn over to you now and, in your practice that encompasses those that are young adults that have this low complexity congenital heart disease, how do you manage them now? And how might the results of this study suggest, potentially, a different management strategy? Dr Gerald Greil:                 Usually these patients, they're kind of thought to be cured or only needed minimal follow up in the past. So, if you take a patient with a VSD, rarely during childhood, young adult or even kind of in 20s and 30s, you have any major difficulties. And as a pediatric cardiologist, you rarely experience any major follow up problems with these patients. I think, particularly in the US, and I work actually for more than 10 years in the UK, the problem in the US is how can you organize follow up in these patients?                                                 There're insurance issues, there're issues about moving into different areas, and since these patients were kind of labeled as being healthy and close to normal, they were lost for follow up, particularly in the US. I think this study raises some concerns, we should probably be more careful and cautious and follow these patients up kind of in a lifelong session. And take care of them. This is definitely something, which is a new finding, and what the cause is, how we are following up, that's the question. I guess it could be a good question for future studies. Dr Greg Hundley:             You mentioned future studies. Specifically, what type of future studies do you think we need to perform next? This shows us that the events are occurring, are we ready yet for randomized trials to perform prevention? Do we need studies that have more frequent observation? What are your thoughts there? And I'll get your answer and then we'll come back to James and get his thoughts on the same question. Dr Gerald Greil:                 Yeah, I think the major thing is we need close follow up of these patients. And it will be a combined effort between pediatric and specialized adult cardiologists, with a special interest in patients with congenital heart disease. Once again, coming back to it, a closer follow up is a little bit dependent on the medical system, which you have. If you take Canada and the UK, it may be easier in these patients are under close follow up. And this allows large multicenter studies, large data bases like UK Bio Bank are kind of exemplary. And we should try to get something similar within the US or in other countries.                                                 I think that's the lesson what we take from that, we need larger data bases, probably more granular than what we have right now. I mean, James probably can comment in a second about the shortcomings and what can be done better in the UK Bio Bank to allow more detailed conclusions than we have currently from his study. Dr Greg Hundley:             James? Dr James Priest:                I would agree with that. I think as a person who does not, clinically speaking, take care of adults with congenital heart disease, my colleagues and I, or I have the impression from my colleagues that for most of the time, in most of these patients in the Unites States adults who had VSD or ASD repair as a child, they were essentially said, oh, you're cured. And they perhaps had some follow up during childhood, but then were otherwise discharged to live the rest of their lives.                                                 And so, in many cases I'd say the first step before performing any studies is to simply identify who these patients are, and figure out you know, what their risk factors otherwise for cardiovascular disease might be. Now, that being said, I think that was one of the powerful things about the UK Bio Bank study is that there's a large population in which all these traditional cardiovascular risk factors you know, obesity, lipid levels, hypertension, smoking status, all these things were uniformly measured in both the individuals with congenital heart disease, the adults with congenital heart disease. And of course the control population.                                                 And so that allowed us to make some estimates about what proportion of disease was attributable to these traditional cardiovascular risk factors. And what was attributable to other factors related, potentially, to the congenital heart disease. But all those things being said, I think the first questions that I often to tend to receive about these studies from the pediatric cardiologists and the adult congenital heart disease doctors, reflects the sorts of data sets that we're used to looking at.                                                 Well, what sort of an intervention did this person have? Did they have a ventriculostomy? When did they receive their diagnosis and their repair? Details of the surgical care and the perioperative of course, are not available in this data set because it's not a particularly pediatric cardiology focused data set. It's a broad population based data set. And so the relationship specifically the details of their perioperative care and diagnosis are not able to be attained. And so we'll need larger data sets that include that information to fully start to develop those sorts of relationships over time. Dr Greg Hundley:             So, we want to thank our lead author, Dr James Priest from Stanford University School of Medicine, and our associate editor, Gerald Greil from the University of Texas Southwestern Medical School in Dallas. And reviewing this very interesting article on lower complexity cardiovascular disease and its association with an increased risk of cardiovascular events. And thank you both so much for clarifying. It sounds like an opportunity to collect more data through registries, et cetera, that we may need to expand around the world.                                                 Thank you everyone for listening to Circulation on the Run. Remember that's your back stage pass to our journal. And we'll see you next week.  

We welcome James Priest back with a new book! A little politics, a little update and a lot of background - it's always wonderful to spend time with James Priest. His new book answers a lot of the questions that he's asked on a regular basis - definitely worth more than the $2.99 that the Kindle version is listed at - and filled with links to great info. Check it out here: https://www.amazon.com/Did-Know-This-About-Cannabis-ebook/dp/B07C9DBNLH/ref=sr_1_1?s=digital-text&ie=UTF8&qid=1522541111&sr=1-1 If you are on disability, receive Medicaid or are a disabled veteran, check out Haven CBD for discounted cbd products at www.havencbd.com . Catch up with us here: http://www.cbdtalkpodcast.com/ https://www.facebook.com/cbdtalkpodcast/ https://twitter.com/cbdtalkpodcast https://soundcloud.com/cbd-talk-podcast/ Also, get information on CBD from https://www.reddit.com/r/CBD/

Tag along as we take a trip to the suburbs of Princeton New Jersey as we have a conversation with James Priest that dances around the word Lambic, the world of spontaneously fermentation, the beer scene was he see’s it and the general in and outs of what he does at his spot The Referend Bier Blendery in Hopewell, New Jersey.

This week on Profile of 20 Young Poets, Arlo Priest Forsyth from Logan Park High School shares his poetry including The Dance of Thumbs, NCEA Approved and Case Not Solved. Broadcast on Otago Access Radio www.oar.org.nz

Join us as we speak with James Priest - cannabis activist and author of numerous articles on cannabis: the industry, the lifestyle and the medicine. We will talk about the changes he's seen and the upcoming trends as well as hopes for the future of this powerful plant. If you are on disability, receive Medicaid or are a disabled veteran, check out Haven CBD for discounted cbd products at www.havencbd.com . Catch up with us here: http://www.cbdtalkpodcast.com/ https://www.facebook.com/cbdtalkpodcast/ https://twitter.com/cbdtalkpodcast https://soundcloud.com/cbd-talk-podcast/ Also, get information on CBD from https://www.reddit.com/r/CBD/

Claude Monet lived at Giverny for 43 years, from 1883 to his death in 1926. A passionate horticulturalist, his garden became a work of art as well as a subject for his paintings. From the Iris garden to his huge waterlily canvases, the garden at Giverny was the focus for some of Monet’s greatest works of art. In this podcast, James Priest, head gardener at Giverny, is in conversation with garden designer and writer James Alexander-Sinclair, discusses Monet’s cultivation of and relationship with the garden that inspired some of his most famous paintings. Image caption: video still Monet's garden at Giverny © Royal Academy of Arts

A tale of the Morrigan, a Vision-Quest and the Lay of Brighid In this tale we hear about the old Shannachie, Laoidheach, who visits a clan to bring them news. He is encouraged by a lively young woman to tell tales of the Old Gods. So he tells her all he knows of the Morrighan and takes her on a Vision Journey. Afterwards, she asks him to teach her the Lay of Brighid. Full Shownotes, with sources and credits, can be found on our main Website at http://celticmythpodshow.com/irish26 Running Order: Intro 0:40 News & Views 1:14 Story 2:52 Listener Feedback - Bel, Liz and Scarlet 26:28 Promo - Kirins 31:02 Promo - Tribeways 33:40 We hope you enjoy it! Gary & Ruthie x x x Released: 16th May 2009, 37m Please send us a message! We love to get your feedback, please email garyandruth@celticmythpodshow.com, or call us on Speakpipe   News & Views We apologise for getting Cindy Spear's name wrong in our last show, the Beltane 2009 Holiday Special, SP11. We called her Cindy Ross instead of Cindy Spear. We also offer support for our Contributing authors who are offering Competitions. We have two to tell you about - both of whom have excerpts from their books for us to perform later on in the year. Rhonda Carpenter, author of The Mark of a Druid has competitions on her website. Christine Rose, author with Ethan Rose, of Rowan of the Wood, is running a competition with a Kindle 2 as a prize which you can find details about on their website.   Blood and Fire Names Used in this Story Listed in order of appearance For more information about the Characters below, see our Biographies section. Laoidheach the Shannachie Ulaid Beltainne Shannachie Moya Gráinne Faolán Morrighan Teamhair Fianna Mechi Magh Mechi Magh Fertaige Mac Cecht Erin Magh Luathad Cu Chulainn Conchobar Finched Cualgne Cruachan Taichinem Conaire Mor Odras Connac Hua Cuined Sidhe Falga Sliabh Buane Magh Rath Congal Claen Cluantarbh Murchadh Brian Badb Dunbolg Aedh Niall Brighid/Brigit Leinster Aine Manannan Cathair Aine Leanan Sidhe Oilioll Oluim River Maigh Luimnech Magh Mucruimhe Magh Mucruimhe Craig Liath Aoibhell Munster Dubhlaing ua Artigan Meardha Connachta Lochlann Muirthemne River Liffey Catháir the Great Curragh Logaire Ailill Áne Labraid Longsech Dinn Rig Cobthach the Slende Lore Oengus of Róiriu Maistiu Mug Airt Alenn Crimthan Bresal Bree Elg Fiachra Fobree Ferus Finn Roth Sétna Carbre Niafer Fiachna Fomuin Bregia Iuchna Tadg Nuada Necht Feradach Dunlang Fornochta Illan Enna Cormac Carbre Colman Brandub Faelan the Fair Fianamail Braiin Conall Dian    Listener Feedback Bel, Liz and Scarlet We read a message from Bel and listen to voice feedback from Liz and Scarlet from the Lakefront Pagan Voice podcast.    Promo - Kirins by James Priest Kirins: The Spell of Noan A race of tiny, magical beings lives on Earth today. They dwell in elaborate tree homes and mysterious underground sanctuaries. Because of an ancient dispute, however, humans are unaware of their hidden civilization. They are kirins. For thousands of years they lived in peace. But a deadly menace now threatens their existence. A party of daring explorers, led by the wise magician Speckarin, is sent on trained ravens to destroy an evil lurking a continent and an ocean away. Failure of this mission would mean death to the voyagers and the entire kirin race. But their success will depend on aid from a truly unexpected source, human beings. Fly with these adventurers and witness today's world as it has never before been seen. You'll find yourself looking to the skies for this mystical race of beings, because maybe, just maybe . . . You can access this Podiobook on podiobooks.com or James Priest's website. Promo - Tribeways Tribeways: The ADF Podcast Tribeways The ADF Podcast (now sadly pod-faded) is a selection of recordings broadcast each High Day featuring liturgy, essays, reviews, chants, poetry, music, workshops and celebrations from ADF members. Tribeways runs on submissions, so please see our submission guidelines to get involved! Ár nDraíocht Féin   Promo - Lakefront Pagan Voice The Lakefront Pagan Voice I’m Scarlet, an eclectic pagan living in Milwaukee, WI, next to beautiful Lake Michigan. Join me for discussions on pagan topics and more. Please feel free to contact me, my email is lakefrontpaganvoice@yahoo.com and you can find me on MySpace, FaceBook and PaganSpace. Feedback feeds the soul and makes the podcasters world go round!   Sources used in this Episode http://www.sacred-texts.com/neu/celt/gafm/gafm15.htm http://www.sacred-texts.com/neu/celt/gafm/gafm14.htm http://www.sacred-texts.com/neu/celt/gafm/gafm16.htm http://www.maryjones.us/ctexts/brigithymn.html#english SOURCES: The Book of Leinster. l.7148-25. "Hail Brigit": an Old-Irish poem on the Hill of Alenn. ed. and trans. Kuno Meyer. Halle a.S., M. Niemeyer, 1912. And, of course, the Awen - inspiration and imagination!   Special Thanks For incidental music: Armolithae, Endless Blue, Artanis, Before Midnight and Lost in the Green Sea from Artanis. See the Contributor Page for details. Evan, Peut Etre Part 3 from Rever... Peut-etre.. See the Contributor Page for details. Diane Arkenstone The Secret Garden. See the Contributor Page for details. Kim Robertson, Angels in Disguise, All or None . See the Contributor Page for details. Jigger Time Ticks Away. See the Contributor Page for details.   For our Theme Music The Skylark and Haghole, the brilliant Culann's Hounds. See their Contributor page for details.   Extra Special Thanks for Unrestricted Access to Wonderful Music (in Alphabetic order) Anne Roos Extra Special thanks go for permission to use any of her masterful music to Anne Roos. You can find out more about Anne on her website or on her Contributor page. Caera Extra Special thanks go for permission to any of her evocative harping and Gaelic singing to Caera. You can find out more about Caera on her website or on her Contributor Page. Celia Extra Special Thanks go for permission to use any of her wonderful music to Celia Farran. You can find out more about Celia on her website or on her Contributor Page. Damh the Bard Extra Special thanks go to Damh the Bard for his permission to use any of his music on the Show. You can find out more about Damh (Dave) on his website or on his Contributor page. The Dolmen Extra Special thanks also go to The Dolmen, for their permission to use any of their fantastic Celtic Folk/Rock music on the Show. You can find out more about The Dolmen on their website or on our Contributor page. Keltoria Extra Special thanks go for permission to use any of their inspired music to Keltoria. You can find out more about Keltoria on their website or on their Contributor page. Kevin Skinner Extra Special thanks go for permission to use any of his superb music to Kevin Skinner. You can find out more about Kevin on his website or on his Contributor page. Phil Thornton Extra Special Thanks go for permission to use any of his astounding ambient music to the Sonic Sorcerer himself, Phil Thornton. You can find out more about Phil on his website or on his Contributor Page. S.J. Tucker Extra Special thanks go to Sooj for her permission to use any of her superb music. You can find out more about Sooj on her website or on her Contributor page. Spiral Dance Extra Special thanks go for permission to use Adrienne and the band to use any of their music in the show. You can find out more about Spiral Dance on their website or on their Contributor page. Get EXTRA content in the Celtic Myth Podshow App for iOS, Android & Windows Contact Us: You can leave us a message by using the Speakpipe Email us at: garyandruth@celticmythpodshow.com. Facebook fan-page http://www.facebook.com/CelticMythPodshow, Twitter (@CelticMythShow) or Snapchat (@garyandruth), Pinterest (celticmythshow) or Instagram (celticmythshow)   Help Spread the Word: Please also consider leaving us a rating, a review and subscribing in iTunes or 'Liking' our Facebook page at http://www.facebook.com/CelticMythPodshow as it helps let people discover our show - thank you :) If you've enjoyed the show, would you mind sharing it on Twitter please? Click here to post a tweet! Ways to subscribe to the Celtic Myth Podshow: Click here to subscribe via iTunes Click here to subscribe via RSS Click here to subscribe via Stitcher   Save