Spectrum Autism Research

The biochemist, who died last month at age 92, was part of the first neurobiology department in the world and showed that gamma-aminobutyric acid is inhibitory.

Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.

Nociceptors tamp down the production of reactive oxygen species in response to heat, chemical irritants or toxins.

In this 2006 Cell paper, Shigeo Takamori and his colleagues showcased the molecular machinery of synaptic vesicles in outstanding detail. Their work taught me that these aren't just passive containers for neurotransmitters but dynamic, precision-built nanomachines.

With an eye toward realism, the neuroscientist, who has a new study about bats out today, creates microcosms of the natural world to understand animal behavior.

Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.

Disrupting the astrocyte-neuronal dynamic in mice destabilizes their memory of fear conditioning.

A protective screen of spurious transcriptional activity enables each olfactory neuron to express exactly one out of hundreds of olfactory receptors.

A researcher's theory hangs muscle degeneration on a broken neural circuit.

We asked nine neuroscientists how they are using FlyWire data in their labs, how the connectome has transformed the field and what new tools they would like to see in the future.

Functional synapses between brain cells and cancer cells are key to the metastatic growth, according to new findings from two independent teams.

Despite the many psychedelics clinical trials underway, there is still much we don't know about how these drugs work. Preclinical studies represent our best viable avenue to answer these lingering questions.

Building reproducible systems across labs is possible, even in large-scale neuroscience projects. You just need rigor, collaboration and the willingness to look your own practices dead in the eye.

The mapping, which traces how the central nervous system interacts with the rest of the body, challenges the idea that behavior control is centralized.

Concerns include the administration's reliance on weak, correlational evidence rather than established research.

The traditional mechanistic framework must give way to a richer understanding of how brains actually generate behavior over time.

Friedemann Zenke's 2019 paper, and its related coding tutorial SpyTorch, made it possible to apply modern machine learning to spiking neural networks. The innovation reinvigorated the field.

The map of a comb jelly's aboral nerve net, which helps the animal orient and position itself within the water column, reveals a unique system for sensing the world and coordinating movement.

The notice, posted last week in Nature, follows a recent string of corrections to at least three other articles by Li-Huei Tsai's lab.

These partnerships accelerate neuroscience by enabling researchers to share resources and expertise, as well as generate more relevant and reproducible results. But new federal funding restrictions in the United States are putting such collaborations in jeopardy.

The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.

During waking hours, a specialized set of sleep neurons in the fly brain accumulates reactive oxygen species, which eventually trigger sleep to clean up and repair the damage they do.

Black In Neuro is launching a new program to help historically Black colleges and universities advance neuroscience research and education, focusing on cross-institutional collaboration, joint curriculum development and improved mentoring initiatives.

In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13 experts to chime in.

By contrast, varied doses of the same genes decrease or increase the odds of five other conditions, with distinct biological consequences, two new preprints show.

The networks are plastic, connect brain regions that aren't connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

Efficiency isn't everything. The cognitive work of struggling with prose may be a crucial part of what drives scientific progress.

The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.

Dig into an exploration of the fundamental aspects of intelligence, a new textbook about theoretical neuroscience and a memoir about memory research, among other new releases.

Funding from the Swartz and Sloan Foundations helped bring physicists and mathematicians into neuroscience for more than 30 years.

Researchers are developing software entirely through natural language conversations with advanced large language models. The trend is transforming how research gets done—but it also presents new challenges for evaluating the outcomes.

The results from a new longitudinal study contradict classic findings in monkeys but may not warrant a rewriting of the textbooks just yet.

Around 30 minutes of imaging per person seems to be the “sweet spot” for linking functional connectivity differences to traits in an accurate and cost-effective way.

Capturing the rodents' vocalizations and movements in the wild offers an opportunity to study naturalistic behaviors in a complex urban environment, Mackevicius and Peterson say.

An explosion in open-neuroscience datasets has created a new generation of researchers with expertise in data science. But new federal restrictions in the United States put their research programs in jeopardy.

Grouping people with autism based on shared features, genetics and co-occurring conditions may improve clinical trial outcomes, researchers say.

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

By isolating specific neuron types involved in zebra finch birdsong, this 2002 Nature paper from Michael Fee and colleagues revealed elegant neural mechanisms controlling the timing of natural learned behavior.

Our current approach is largely arbitrary. We need new methods for grouping cells, ideally by their dynamics.

The “love hormone” drives the neurobiology behind platonic bonds in animals usually studied for their romantic attachments.

The editor-in-chief cited “inconsistencies in the number of subjects” as the reason for the retraction.

The new study challenges a long-held view that the barrel cortex exclusively encodes sensory signals from the whiskers.

Neural manifold properties can help us understand how animal brains deal with complex information, execute flexible behaviors and reuse common computations.

Analyses that include low-quality MRI data underestimate cortical thickness and overestimate cortical surface area, according to new findings from the Adolescent Brain Cognitive Development (ABCD) Study.

Post-puff brain state might not be an emotion, some researchers caution, but the protocol provides a cross-species approach to study emotions.

Neuroscience in other countries will strengthen—at the United States' expense—as rising visa restrictions and rejections block many international students from enrolling at U.S. institutions and dissuade others from applying.

The tool leverages a previously unused segment of the color spectrum to track the neurotransmitter and can be used with two additional sensors to monitor other neurochemicals at different wavelengths.

Variants in genes tied to both conditions derail the formation of cilia, the tiny hair-like structure found on almost every cell in the body, a new study finds.

Computational sciences offer an opportunity to increase global access to, and participation in, neuroscience. Neuromatch's inclusive, scalable model for community building shows how to realize this promise.

The findings from Charles Zuker's lab put the taste system on the map, revealing that some fundamental principles of behavior are hardwired.

Brain function is inexorably shaped by the body. Embracing this fact will benefit computational models of real brain function, as well as the design of artificial neural networks.