Podcasts about evolutionarily

Evolutionarily newer regions sport mitochondria with a higher capacity for energy production than older regions, according to the first detailed map of the organelles in a tissue slice, adding to mounting evidence that the brain features a metabolic gradient.

Evolutionarily speaking, it makes sense to have a lot of children. At the very least, we might expect a population to replace itself, with each couple having an average of two children. However, this evolutionary logic is not mirrored by current data: birth rates are falling in the UK, with many people choosing to either have one child, or no children at all. We speak to evolutionary anthropologist Dr Paula Sheppard about the drivers, and consequences, of this observed trend.

In this week's episode, I talk about the 4 main benefits of asking for help, from Brene Brown and Dr. Laurie Santos of the Happiness Lab. 1) True friendship involves reciprocal helping (not just one-sided help). 2) Evolutionarily, we were made to help each other, to live in tribes, and if we were alone and did not help others and accept help from others, we died. 3) When we help others, it makes us feel better which means that when we ask others for help, it also makes them feel better. Win/win! 4) asking for help helps avoid burnout and resentment, like the time when I refused to ask my husband to get me some bread when I had no time (last week) and instead just grumbled all week about having no bread. Resentment city. Action item: try to ask for help today or this week!

Our limbic system (commonly called the lizard brain) plays an important role in our safety. If it's over-functioning, however, we can feel chronically unsafe.Previously, I discussed how the autonomic nervous system (ANS) puts us into fight, flight, or shut down when we feel threatened. The ANS operates largely outside our brain; however, it communicates with our limbic system, which is in the brain. In this newsletter:* What is the limbic system, specifically the amygdala, and how does it keep us safe?* What symptoms and conditions occur when the amygdala is over-functioning? * What does the limbic system have to do with high immune reactivity and mast cell activation, multiple chemical sensitivity, and electromagnetic hypersensitivity?* Are some of us born with an overactive amygdala?* What environmental inputs can lead to limbic system dysfunction?* How can we take advantage of neuroplasticity to address this dysfunction, feel safe in our bodies and environments, and become less reactive to food, chemicals, light, loud sounds, EMF, and other environmental inputs?What Is the Limbic System?The limbic system is a group of interconnected structures deep inside the brain (and just above the brainstem) that govern our emotions, motivation, sense of smell, and behavior.  Evolutionarily, the limbic system is considered the oldest part of the human brain.  It has been identified in fish, amphibians, reptiles, and early mammals. The structures include the thalamus, hypothalamus, basal ganglia, cingulate gyrus, hippocampus, which consolidates short-term memory into long-term memory, and last but most certainly not least, the amygdala.The Amygdala* a major processing center for emotions, especially fear, anxiety, and rage.* helps identify potential threats and trigger appropriate reactions, such as the "fight or flight" response.* stores emotional memories, especially those related to stress and fear.* helps with social interactions and interpreting information about others.* involved in learning by fear, and is necessary for acquiring both active and passive avoidance of conditioned responses.* assigns value to objects and activities; plays a role in making judgments, including social, moral, and aesthetic judgments.What is Limbic System Dysfunction?This is when neuronal pathways have been reinforced from repeated threatening inputs. What is perceived as threatening starts to become generalized. This can look like:* high anxiety and even obsessive-compulsive symptoms, such as contamination fears, disordered eating, body dysmorphia* hyper-vigilance or being excessively alert to anything perceived as a threat* excessive fear related to:* one's symptoms* one's body* food, medications, or supplements* environmental exposures, such as chemicals, mold toxins, or EMFBecause of the interconnection between the central nervous system and our immune system, once someone has developed limbic system dysfunction from toxic exposure or trauma, they can become hyper-reactive to a wide range of stimulation, including light, sound, smells, foods, supplements, medications, chemicals, and electromagnetic fields.  As you can see, this becomes self-perpetuating. As a person has more reactions, often in the form of mast cell activation with its wide range of symptoms, they become more vigilant and avoidant to try to prevent symptoms. This adaptive response, however, further reinforces a hyper-vigilant limbic system.What Does It Feel Like?I can speak to this personally, as I had limbic system dysfunction from mold toxicity (from a home that had water damage) and then later in a new Smart house with high radio frequencies and dirty electricity. Even before I knew I had mold toxicity and was being exposed to mold, my thoughts repeatedly landed on themes around safety. I knew something was causing me to have severe fatigue and headaches, but I didn't know what. “I shouldn't eat that, I shouldn't go there, I shouldn't, I can't, I better not.” I thought if I could control things, I would be fine. Everything and everyone felt “too much.” It was hard to be with people. When our body feels threatened, we are not at rest, digest, and connect. It's difficult to be present. That's a problem because the less we connect with others, the more room in our minds for rumination and reinforcing those fear pathways. My symptoms of pain, fatigue, and anxiety caused by mold toxins and EMF were helped and made worse by the limbic dysfunction that developed. If you've ever been “limbic,” you know it's all-consuming and exhausting, not just for you but for your spouse, partner, children, and close friends.Can We Be Born with Limbic System Dysfunction - “Wired For Danger?”RCCX is a gene module (cluster of genes) that appears to be at the foundation of many psychiatric conditions and complex chronic health conditions, such as mast cell activation syndrome (MCAS), chronic fatigue syndrome, chronic inflammatory response syndrome (CIRS), and postural orthostatic tachycardia syndrome (POTS)The RCCX gene module includes a gene for hypermobility (especially bendable or double-jointed), a gene for 21-hydroxylase - involved in stress hormone pathways, and a gene related to our immune response and autoimmunity.  Hypermobility is a red flag but not a requirement.A weakness in 21-hydroxylase can result in higher androgens (such as testosterone) in utero and thus impact the developing brain, specifically the amygdala. Studies have found that those with hypermobility have a larger than normal amygdala, which fits RCCX theory.   This would suggest that many of us come into the world with an amygdala that already has us on high alert. The disadvantage of the resulting global sensitivity is the greater potential for health consequences. However, there can also be advantages, including being highly intuitive, observant, creative, and empathic. Another seeming result of high androgen exposure in women during development is a finger length ratio more typical of men (the ring finger is longer than the index finger when looking with the palms up).   Perhaps the male finger length ratio in women and girls suggests a vulnerability to developing limbic system dysfunction.Neuroplasticity - Friend or Foe?Neuroplasticity is the incredible ability of our neurons to form new connections and modify the strength of existing connections. More simply put, it is the ability of our brain to rewire itself. Our experiences, thoughts, and behaviors drive these neuronal connections. As you'll see, neuroplasticity can work against us and take us into or further into limbic system dysfunction, or it can help us find our way out of limbic system dysfunction.How Do We Develop Limbic System Dysfunction?I do suspect that many of those who go on to develop limbic system dysfunction already had a vulnerability from the start; however, environmental inputs - exposures or trauma - can reinforce those neuronal pathways of fear and avoidance. Such experiences could start as early as the first three years of life.  Perhaps one's attachment experiences left them feeling unsafe and uncertain that the world was safe. There could have been trauma. Over time, toxins could have left the body feeling chronically threatened. We see this with biotoxins, especially from mold and Bartonella, but also with Lyme and other co-infections. We also see this with high EMF exposure and chemical exposures. Though we call it dysfunction, hypervigilance can lead people to their answers. Had I not been “limbic,” I probably wouldn't have discovered I had mold toxicity, but once I did, I had to teach my brain and body how to feel safe again,… perhaps even safe for the first time.Limbic System RetrainingJust as pathways of fear and vigilance can get reinforced over time, so can pathways of safety and well-being.  Limbic system retraining programs are structured programs with exercises, education, and support to help retrain the limbic system. They are incredibly helpful for most people, even those with an active “threat” like mold toxins in their body.  That doesn't mean that actual external threats don't need to be addressed. Just as I wouldn't recommend someone stay in a traumatizing relationship, I also wouldn't recommend someone stay in an environment in which they are getting significant exposure to mold toxins.Limbic system retraining programs can be done at home online. Common ingredients include raising awareness of thoughts and triggers, interrupting those thoughts (with or without movements), and a visualization or mood elevation. All of these require practice. The three programs that I have patients look into and which many of us who treat complex illness have the most experience with are:* Dynamic Neural Retraining System (DNRS)* Gupta Program* Primal Trust Though these vary somewhat (DNRS is the most structured, Gupta brings in meditation, and Primal Trust brings in more vagal nerve interventions and trauma-informed practices), they are all effective. It comes down to fit and which program the person feels the most drawn to and, thus, will be most inclined to do.  While an hour a day may be recommended by the programs and maybe most helpful, it does not have to be “all or none.” Even ten minutes a day to start can still be helpful.For patients who are so sensitive that they can not tolerate any supplements, binders (for toxins), or medications to calm down their immune and/or nervous system, limbic system retraining and vagal nerve interventions for eight weeks usually can allow them to move forward. Again, because the immune and central nervous systems are so interconnected, as the limbic system calms down, so do mast cells, inflammation, immune reactivity, and the many symptoms that they can cause.  Who Benefits From Limbic System RetrainingLimbic system retraining programs - specifically the Dynamic Neural Retraining System, not surprisingly, were first used for Multiple Chemical Sensitivity (MCS), Chronic Fatigue Syndrome (CFS), Electromagnetic Hypersensitivity Syndrome (EHS), and Fibromyalgia. They are also used for Mast Cell Activation Syndrome (MCAS), Chronic Inflammatory Response Syndrome (CIRS), mold toxicity and other biotoxin illness (Lyme and it's coinfections), Post Traumatic Stress Disorder (PTSD), Obsessive Compulsive Disorder (OCD) and more generally for: * Those who have experienced physical, psychological or emotional stress and trauma and who are now suffering from a chronic health condition* Those with chronic depression and/or anxiety* Those with chronic painHow to Help Children Limbic System DysfunctionOlder children and teens can benefit from doing limbic system training program with a parent. My daughter and I did DNRS together. Our conversations about it were reinforcing and still shape how we each think about how to support our neurophysiology.  For younger children, following the steps may be more difficult. Programs like Brain Tap and Dr. Stephen Porges' “Safe and Sound” program can be very helpful. Honoring Our Limbic SystemBefore I close, I would again point out that our amygdala - beyond keeping us safe - is the source of many of our gifts - our sensitivity, intuition about people, and inner knowing. Those of us who come into the world “wired for danger” are also wired to see things others may not see and feel things others may not feel. We can use such gifts to serve a higher good. Whether or not you struggle with limbic symptoms, I hope something here helps you appreciate your limbic system so that it can help you find peace and purpose.Until next time,Courtney To learn more about the roots brain-related symptoms and discover surprising paths to healing, consider becoming a free or paid subscriber.Medical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Season 3, Episode 9 - Ministry and The Motivational Triad.The Motivational Triad:1. Seek Pleasure: The desire for positive experiences, comfort, and reward. This is rooted in the brain's reward system, where pleasurable activities trigger dopamine release. 2. Avoid Pain: The instinct to minimize physical and emotional discomfort. This includes avoiding danger, stress, or anything perceived as unpleasant. 3. Conserve Energy: The tendency to avoid unnecessary effort or exertion. Evolutionarily, conserving energy was important for survival when food was scarce.Resources:Spotify Podcast PlaylistInstagram @nicolereilleycoachingFacebook @nicolereilleycoachingMinistry & Life Coaching and Social Media Management at NicoleReilley.com.Expanding the Expedition Through Digital Ministry by Nicole Reilley at AmazonContact me: RevReilley@gmail.comwww.NicoleReilley.com

Welcome to the third episode of our emotional liberation series. In this episode, I discuss the relationship between courage and fear, exploring how these two emotions are intertwined and essential for personal growth. You can't have one without the other; both are crucial for development. Nature of Fear: Fear is a natural emotional response to a perceived threat or danger. It aims to protect us from harm by triggering the fight or flight response. Evolutionarily, fear has been vital for our survival. In modern life, fear often manifests as procrastination, indecision, and perfectionism. How to Manage and Reframe Fear: Acknowledge fear without judgment. Recognize that fear is often linked to vulnerability, the unknown, and uncertainty. Understand that fear can be very loud and overwhelming. Use fear as a tool for personal evolution, leading to courage and growth. View fear as an opportunity to be courageous. Courage: Courage involves feeling the fear and acting anyway. While fear is debilitating, courage propels us into action. Courage is the ability to face fear, pain, or adversity with bravery. It enables action despite feelings of vulnerability, exposure, or uncertainty. Courage is not an innate trait but a skill developed through practice. Demonstrating courage is inspirational. Practical Strategies for Building Courage: Take risks: Be open and embrace failure. Set goals: Start with small, courageous goals and celebrate your progress. Reflect on past experiences: Consider times when you've shown courage despite fear. Cognitive Behavioral Techniques for Embracing and Managing Fear: Strategy #1: The Fear Ladder Choose a specific fear. Clearly define it. List all related situations. Rank these situations from least to most scary. Start small and gradually progress, sharing your progress. Remember, it's not a linear process; you can move back down if needed. Strategy #2: Detailed Fear Analysis Write down what you fear and why. Assess if the fear is based on real danger or a perceived threat. Rate the likelihood of the fear materializing on a scale of 1-10. Identify the underlying emotions. Challenge the fear by examining evidence for and against it. Recall past experiences where you've overcome similar fears. Take action to face the fear, possibly using the fear ladder. Resources mentioned in this episode: Previous podcast episode on fearTed Talk - What I learned from 100 days of rejection Connect with Brittny:Instagram: @brittnyking_Website: www.brittnyking.comEmail: hello@brittnyking.com

Today, you'll learn about how a population of female chimps have surprisingly been found to go through menopause and live well beyond their reproductive years, an ancient tsunami and its devastating impact on stone age populations, and the dire effects of sexism in science. Chimp Menopause “Surprisingly long-lived wild female chimps go through menopause.” by Bruce Bower. 2023. “Wild Chimps Shown to Undergo Menopause for the First Time.” by Joanna Thompson. 2023. “Evolutionarily, grandmas are good for grandkids - up to a point.” by Sujata Gupta. 2019. “Why postmenopausal women are so crucial to our evolutionary success.” by Alice Klein. 2024. Ancient Tsunami “Tsunami 8,000 Years Ago May Have Devastated Stone Age Community - Study.” by Aristos Georgiou. 2024. “Possible Tsunami Risk as Geologists Discover 45-Mile-Long Hidden Fault.” by Jess Thomson. 2023. “The Historic Storegga Slide & Tsunamis.” by David Nikel. 2021. Sexism in Science “How centuries of sexism excluded women from science.” by Karly Pitman. 2023. “Study shows gender bias in science is real. Here's why it matters.” by Ilana Yurkiewicz. 2012. “What science has gotten wrong by ignoring women.” by Catherine Zuckerman. 2018. “Confronting Sexism in Science, Technology, Engineering, and Math (STEM): What Are the Consequences? By Eden J.V. Hennessey. 2018. Hosted on Acast. See acast.com/privacy for more information.

Linked to metabolism and even menopause, weight gain for many over 50s seems inevitable, but is it really? We ask celebrity GP Dr Brad McKay for his take, and speak to author Jacqui Hodder about how she overcame an expanding waistline to embark on a trip of a lifetime.  About the episode - brought to you by Australian Seniors.  Join James Valentine as he explores the incredible stories of Aussie characters, from the adventurous to the love-struck. Across 30 inspirational episodes, Life's Booming explores life, health, love, travel, and everything in between. Our bodies surprise us in ways we never thought possible as we age, so in series five of the Life's Booming podcast – Is This Normal? – we're settling in for honest chats with famous guests and noted experts about the ways our bodies behave as they age, discussing the issues and awkward questions you may be too embarrassed to ask yourself. Jacqui Hodder is a Melbourne-based writer and teacher who embarked on a once-in-a-lifetime trip to track turtles in Costa Rica, documenting her journey in Turtling in Tortuguero. Overweight and prediabetic, she underwent a health and fitness overhaul to help her prepare, and keep up, on the month-long adventure.  Sydney-based GP Dr Brad McKay is an experienced TV and radio broadcaster, podcaster, columnist and author of Fake Medicine. He appears regularly on The Today Show, The Drum, ABC Radio, triple j, Triple M, has presented Catalyst on the ABC and hosts several medical podcasts for health professionals. He's also on the editorial board of The Medical Republic. If you have any thoughts or questions and want to share your story to Life's Booming, send us a voice note - lifesbooming@seniors.com.au Watch Life's Booming on Youtube Listen to Life's Booming on Apple Podcasts Listen to Life's Booming on Spotify Listen to Life's Booming on Google Podcasts For more information visit seniors.com.au/podcast. Produced by Medium Rare Content Agency, with Ampel Sonic Experience Agency Transcript:  James Valentine: Hello and welcome to Life's Booming series five of this most excellent and award-winning podcast. I'm James Valentine and in this series, we're going to ask the question, Is This Normal? I mean as we age stuff happens to us, our bodies change, things fall off, we get crook, stuff doesn't work as well as it used to. There's nothing we can do about it, we're getting older, we're ageing. But which bits are normal? Which bits do we have no control over? Which bits can we do something about? That's the kind of questions that we're going to be asking in this series, Is This Normal? of Life's Booming. Now, of course, if you enjoy this series, leave us a review, tell all your families and friends about it. And we want to hear from you as well. You can contribute to this. If you've got questions about things in particular that you want to know, perhaps there's some particular wear and tear happening to you. Let us know. We'd love to see if we can answer that question in the series. We're gonna look at things like menopause, gut health, mental health, lots of other burning questions. So, think about those areas and if there's something in there that's specific to you that you'd like us to cover, let us know. And now, on to this episode of Life's Booming, Middle age spread.  Weight gain weighs you down. Both literally, it's gonna weigh you down, slow your body down, and also mentally. You don't feel as good, you're sluggish. You probably don't like the way you look. Whether it's sitting there around your gut, or it's sitting there on your bottom, or it's making your legs fat, or wherever it's gathering. The gaining of weight is something that we all have to face as we get older. And it's not, often not pretty. And not really what we're hoping for. So, how do you lose weight? What do you have to do? Do you have to go off to the 6am bootcamp? Do you have to just eat beans for the rest of your life? What are you going to have to do about it? We've got two good people to talk to about this today. A regular on Australian television programs such as Today and The Project. Kiwi born, now Sydney based GP Dr Brad McKay is going to answer some of these questions and bring his medical knowledge and experience to this. But we've also got someone who's going to tell their story, and it's a very powerful tale. A few years ago, Melbourne author and teacher, Jacqui Hodder, was planning to go on a life changing trip. She wanted to head to Costa Rica, and she wanted to volunteer to help the turtle population there, to survive and to deal with all the threats that are happening to all the wildlife around the world. This was going to take a month. She was going to go there for a month. But it was going to be a physically demanding trip. So, she realised she was going to have to get fit and deal with this. But she'd also just had some big health news as well. It's a great story and inspiring.  James Valentine: Hello, Jacqui.  Jacqui: Hi, James. How are you? James Valentine: Yeah, good, good. Now, what do you usually do? What kind of work do you do? Jacqui: I'm a high school teacher. I teach English and I teach vocational education. And I also look after the careers in the school.  James Valentine: Okay. Oh, you're the career counsellor. Jacqui: I'm the career counsellor. That's right.  James Valentine: Okay, so we come to you, and you tell us, look, you really should be a physiotherapist and then we turn out to be astrophysicists, is that it? Jacqui: Well, the theory is these days, five different careers, not jobs, but careers in your lifetime.  James Valentine: Well, that's kind of you. You've got whole other careers as well, right? Jacqui: Absolutely. Yes. Done many different things over the years, for sure.  James Valentine: And tell me, you write as well.  Jacqui: I do. Yes. I've always wanted to write. I've written a little book about this journey, but also written some short stories and things like that as well. So yes, quite a lovely passion of mine for sure.  James Valentine: And it was, it was part of a writing project that led you to have to deal with some health issues.  Jacqui: Um, the way it came about, if you're happy for me to go on with the story, I was teaching a year nine civics education class, and we had a guest speaker come in who'd been to Costa Rica, and she had worked with a jaguar project in the jungles of Costa Rica, and she was putting all these images up on the board of armadillos and toucans and turtles that she'd worked with. This was at the end of the first year in lockdown in Melbourne, and it was via zoom. And I think something just spoke to me. I think that want for adventure, that, that exciting allure of something different than my house and being somewhere else really grabbed me. It just spoke to me. I thought that's really what I want to do. But obviously because we're on this program, I was quite overweight. I had some health issues. So the first challenge was, would I be able to do it? I had to be able to, according to the program I wanted to go and volunteer with, I had to be able to walk four to five hours on soft sand every night in the tropical humidity, plus, work with the turtles as well at night. So it was quite a physical program I was setting myself up for. So, I just turned 60, this was the beginning of January 2022, and I wanted to go for long service leave in the September. And so I set myself a goal of trying to get fit, fit enough to be able to walk those distances for that length of time. I had to also be able to walk eight to 12 kilometres on the soft sand as well, that was what the guidelines were. So I started off, and I remember my first session was down near where I live, walking down to the beach, along the beach, and then back up this set of stairs and panting quite remarkably as I got to the top, not sure if I'd make it. And that was the beginning.  James Valentine: It sounds like a big aim to me. It's like you've gone from sort of zero to a hundred. You're sort of, you're not going, ‘might just walk around the block'. It's like, I need to be able to rescue wildlife in Costa Rica. It sounds big. Jacqui: Exactly. Right. I just, I don't know. I don't know if you have those moments in your life where things just speak to you. And I was just like, I want to do this. That's something that was very clear in my mind, but I knew I had to get to a certain level of fitness to be able to do it, and I was quite overweight. I was probably about, probably reaching almost 100 kilos and I'm quite a small person. I was five, I'm five foot two and a half. Not was, but I am. So it was quite a challenge. Yes. So, I started with the fitness. I just knew I had that goal of making that distance for that length of time on the soft sand. That was the kind of significant part.  James Valentine: And nothing else up until then, nothing else had prompted you to want to lose weight, right?  Jacqui: Not quite true. I mean, I've been overweight. I've struggled with weight my whole life and I have tried various diets and I've lost weight, but it's always crept back on and that's the significant part for me. How do I keep it off? So, I knew I could lose weight if I really put my mind to it. At that stage, the goal wasn't so much to lose weight. It was to get fit enough to do the program. But when it got closer, I started to worry about keeping up with the young people because I knew there'd be young people on this experience. I knew I was going to be someone who, you know, was the oldest probably. So, I wanted to be able to keep up with the young people at night.  James Valentine: Don't we all? Jacqui: So, I got to April. And I was on holiday, and I was standing up from taking a photo of this family on the beach and I felt something go twang and it was my intercostals. So, I went to the physio and the physio said, she just laid it out for me, which was actually great for me. I didn't know I'd be able to take it so well. She said, Jacqui, you're going to have to go to the gym three to four times a week and do weight training and resistance for the rest of your life.  James Valentine: Wow.  Jacqui: Okay. That's what I need to do, super clear. So, I started going to the gym as well as walking. I still really wasn't losing the weight. James Valentine: Let's go back to, also just go back to that sort of first walk, you know, we left you, you were sort of panting up the stairs back to your house, right? So, that was in that first walk, did you also go, oh, I've got a long way to go?   Jacqui: I've got a long way to go, but I knew if I could dedicate a regular routine to walking, I knew I'd be able to get, it was the distance I was worried about and the time.  I couldn't ever quite make three and a half hours totally on the soft sand and I had to be able to do four to five hours.  James Valentine: Wow. Jacqui: It's really hard walking on soft sand. In fact, when I came back, I swore I'd never walk on a beach ever again.  James Valentine: I don't like having to get back to my towel, quite frankly. So, you know, to do five hours just sounds impossible.  Jacqui: And as it turns out, it was probably overkill, but I can explain that. A little bit later.  James Valentine: Yeah, right.  Jacqui: But yes, I was gradually building up. So, I was going pretty much Mondays after school, I was going Wednesdays, Fridays and on the weekend I'd try and do a long walk, walk on the weekend as well. James Valentine: And you were maintaining that, so that discipline was staying with you, you can see the aim, you can see the turtles on the beach, you can see where you're going.  Jacqui: The motivation was so clear. And that's partly also the challenge because when I came back, I knew the trick would be how to maintain that weight because I wouldn't have that clear motivation anymore. So yes, going to the gym and walking, my routine was getting quite busy at this point because I was going three times.   James Valentine: How many months out from the trip did the intercostals go?   Jacqui: That was April, and I was going in September.  James Valentine: Yeah. So, during that period you then start to do what, do daily gym routine you were saying, daily gym weight routine and walking. Jacqui: I was going to the gym three to four times, so Monday, Wednesday, Friday, Saturday, and then walking as much as I could on those days, but also the in between days as well. But obviously I'm working full time. So, the long walks I could really only do on the weekend.   James Valentine: So, what was happening to your weight? Jacqui: The weight, actually, to be honest, wasn't really changing. I was feeling like I wasn't panting up the stairs anymore. So, I could tell I was getting fitter, but I wasn't actually losing weight. So, when it got to June, I thought, I actually need to take an extra step here, because again, I guess I would be a little bit embarrassed. If I was going to be going to Costa Rica and working with young people, and there I was a very overweight, older person. So in June, I went on a program that I've been on before I knew it worked, which is the CSIRO Wellbeing, Total Wellbeing Diet. And I actually picked up a new book, which is the low carb one, because actually that was the other thing I hadn't mentioned was I had been diagnosed as pre diabetes in April as well.  I've also been on high blood pressure medication and high cholesterol medication for a long time as well.  James Valentine: Right. You've got it all going on at this point. So, you've got to deal with pre diabetes, you've got the intercostals have gone, you've got to get to the gym, you're trying to lose the weight. Jacqui: Yeah.  James Valentine: This is a lot to encompass, isn't it? Prediabetes, what does that suggest is going on?  Jacqui: High blood sugar, so basically, it's a precursor to type 2 diabetes, which is a very serious health issue, as you know.  James Valentine: But at that point it can be dealt with, with diet, right?  Jacqui: It can be, yes. And the doctor was very good. He explained everything to me of what I could do to change my lifestyle, which I was happy to say I've tried, I've already started doing. I've already started the walking, not to lose the weight. I don't think I've ever found, like in terms of the psychological part of losing weight, the kind of fear of health issues has never, unfortunately, been a motivation for me. I'm not sure why, but the motivation to work with turtles was working.  James Valentine: Isn't it funny what it'll take to get us to do some stuff? So by April, May, June, you're at the gym. You're dealing with the diet, you're trying to lose the weight. You're walking, you're slogging yourself through the sand. It's a, it's a brutal routine you've really got onto. What the CSIRO diet, just tell us a little bit more about that. I mean, part of my general understanding is in some ways it's quite straightforward. It's a sort of, you know, meat and salad and you'll be good.  Jacqui: Well, the low carb one actually does, they're not so meat focused because originally that was kind of what we knew about the diet was how much meat or protein was involved.  But the low carb one substitutes a lot of nuts and fish and not much bread or pasta or obviously the carbs. And what I love about the Total Wellbeing Diet, I think, is they have a 12-week program and it really clearly outlines what you need to eat at breakfast and the quantities, lunch, dinner, and it has recipes in there, and it's 12 weeks. And 12 weeks feels manageable. It's a chunked-up amount of time. So, I knew if I could go on the 12-week diet, well, I hoped I'd be able to lose the weight because I had before being on that diet and I succeeded. I lost probably about half of what I've totally lost by the time I was in Costa Rica, so it did work. James Valentine: Okay. Okay. Well, we might leave a cliff-hanger there and we'll, you know, be able to build towards what happened in Costa Rica. Did the turtles attack? We'll get to that part of the story. But I might bring in our very helpful doctor here, Dr. Brad McKay is with us. Hello.  Brad: Hello. Hopefully I can be helpful.  James Valentine: Yes. Excellent. Well, what kind of things are you hearing in that story? I mean, one of the things that struck me is, the exercise wasn't working. We all think we'll be able to burn that fat off. Not necessarily.  Brad: Yeah, it's, it's a very common presentation. So, very commonly, people like Jacqui will be wanting to lose the weight, they'll increase their exercise, they'll change their diet, and the evidence sort of shows that you might be able to lose about two percent of your body weight doing that. If you're really giving it a red-hot go, you might be able to get to five percent of your body weight being lowered, but it's really, really hard to push past that. And if you stop doing what you're doing, so if you stop starving yourself, then you tend to go back to that pre-existing weight. Your body loves to sabotage you and it loves to get back to your highest weight that you've ever been.  James Valentine: Right. So why, I mean, we see all those lean swimmers and football players and they run around all the time and they, you know, they eat a good diet to try and be great athletes. Why are they so skinny and I'm so fat? Brad: Well, they may be younger than you, so that's one thing. But also often those athletes haven't been overweight before. They haven't gone into an obese category, so they've maintained their weight.  Their body isn't trying to sabotage them. It's not trying to get to that heavier weight because they haven't been at that weight before.  James Valentine: Right. And so this has a lot to do with ageing, does it? When we get to a certain age, the weight is going to stay there? Brad: Yeah, so as time goes on, then we generally sort of like waver, we go up and down with our weight, and so every time you're in that flux of change, your body's trying to get to that highest level. So, just with a graph, if you're looking along this wavering line, it just slowly tends up all the time, because that's what your body is trying to do, it's trying to store energy. Evolutionarily, we have designed, our body has sort of evolved to be like that.  James Valentine: So, we're always, so as we age, we always, our body wants to put on more weight. Brad: So, our body wants to store energy to keep us alive for longer in case we can't kill that Saber-toothed tiger next week. We've got to have that energy on board.  But when we have lots of food around, when we have fast food, when fast food is cheap, when we're not exercising as much, if we're not racing around, and competing in Olympic sports, then yeah, we tend to put on that weight. And so that's a very common story.  James Valentine: And so, does that just keep on going? At 50 it'll be X and at 60 it's X and a half? Is it that sort of thing?  Brad: So it's not guaranteed. So, a lot of people do increase their weight and they're able to maintain, increase their exercise and they're able to maintain their weight at that level. Some people get really sick, and they lose lots of weight as well. There's also metabolic factors. There are hormone factors involved too. So, there's lots of variation. It's not inevitable.  James Valentine: So, when Jackie was just exercising, that wasn't doing it. What's the difference when you add diet? Brad: Well, if you're exercising to improve your health, you need to be exercising for about 150 minutes per week. And that's getting to a really high level where you're feeling puffed, where you may be able to have a brief conversation with somebody, but you're not able to sing. That's a great description in medicine for that. James Valentine: But I can't sing anyways.  Brad: You're screwed, yeah. So, the other part of it is if you're wanting to then lose further weight, then you need to be doing about 300 minutes every week at that level.  James Valentine: Right.  Brad: So, if you're wanting to then gain that further, then you've got to be really strict with your diet as well, and certainly a lot of the evidence does just look at the energy in versus energy out. So yeah, if you're not exercising and not using up that energy, then your body is going to store it somewhere.  James Valentine: Right. And so by diet, do we just mean eat less?  Brad: That's also the type of food that you're eating as well. So, if you're eating lots of saturated fats, lots of fat, meaty products, if you're eating lots of white bread and carbohydrates, then yeah, like you're going to be, yeah, maintaining that and your body is going to love that and want to hold on to it. James Valentine: Oh, so different foods are held onto more resolutely by the body.  Brad: There's a lot more energy that's in certain foods compared to others. So, for example, if you're eating lots of vegetables, then you can feel full, if your stomach is full of beans, for example. But you've also got lots of fiber. It takes a long time for your body to digest that fiber. So, you'll have a little bit more energy for longer, rather than just bread that dissolves in your hands. before you're even able to put it in your mouth. So, your whole gut is sort of activated and it takes energy as well to break down that food too. So, the more rough your food is, the more whole greens you have, the more nuts you have, then yeah, it takes longer for your body to break it down. And also, it's not packed full of sugar, which is easily getting into your bloodstream and spreading around.  James Valentine: Now Jacqui, were you, did you know this sort of stuff when you went onto the CSIRO diet? Did you learn it as you went through?  Jacqui: Yeah, the thing about always struggling with my weight is I tried many, many different diets. Kind of know the facts and figures. I'm not sure I knew exactly why there were so many nuts in this particular diet, but it makes sense hearing what Brad's talking about for sure.  James Valentine: What are the things that struck you about the CSIRO diet? What was different?  Jacqui: I like the structure and I really like how each week is, like, it's a 12-week program and each day is pretty much designed for you in terms of quantities, in terms of what you need to eat, in terms of recipes.  So, I find that in a busy life, very straightforward to follow. The trick is what you do afterwards. Once it finishes.  James Valentine: What do you mean by that? Oh, once it finishes. Yeah. So, you mean after the 12 weeks, it doesn't say week 13 Mars Bar?  Jacqui: Well, I actually, I've got some little tips that have helped me, but one of them I think is for me having a day off every week. I hope that's not too naughty, but you know, just because I mean, it's very hard to stick to the same thing day in, day out. So, I give myself like a little treat one day a week where I just think I am going to have some hot chips for lunch, or I'm going to have pizza for dinner or something like that. And then I go back onto it again the next day.  James Valentine: Yeah. What do you think, Brad? Brad: Yeah. So, Jacqui's exactly right. So, what you're wanting isn't just a 12-week program. You're wanting to be able to follow that eating habit for the longer term. And so often you do need a day off because if you don't, you will just fall over at the end of that 12 weeks. You'll go back to your previous eating habits. So yeah, I think it's crafty and it's helpful to do what Jacqui's been talking about. So having those days off and being okay with you, giving yourself a break, giving yourself a bit of leniency. Because you're needing that, to do that in the longer term.  James Valentine: Why don't most diets work? I mean diets usually fail, don't they?   Brad: A lot of diets fail. A lot of people are going along this whole dietary cycle where they are trying everything under the sun. And not one diet works for everyone. Everyone has different metabolisms. So, what may work for Jacqui may not work for you. So yeah, you will have lots of Instagram influences and people online telling you that their green smoothie is going to be helpful for you losing weight.  James Valentine: But it's also, diets will often be around a fad, which will be, you know, one particular food, or one particular activity, or one particular way of thinking. Now again, that's hard to maintain, isn't it?  Brad: Yeah, if you're on a grapefruit diet, then you're probably not going to be doing that forever. James Valentine: Yeah, yeah. What's different about the CSIRO one?  Brad: So, it's a bit more about healthy eating, and having healthy habits, and being able to continue it in the longer term. Also, the variety is really important because you're needing to not get bored by that grapefruit that you're having every day. You're needing that variety, that spice of life.  James Valentine: Yeah. The other thing I was struck by Jacqui, and let's, I asked you this sort of a little earlier, but you know, let's talk about it a little bit more. The motivation was, is so curious in a way, it is quite an extreme thing that it's like you suddenly went, I wouldn't mind white water rafting, you know, kayaking or something. It's like you took quite a big step. It took a motivation that was a big step out of your normal life. Why had motivation failed before? What, what, why doesn't the motivation of just, I want to lose weight, I know that's important. Why isn't that enough?  Jacqui: It's interesting, isn't it? I mean, if I knew the answer, maybe I wouldn't have waited till I was 60 to finally lose some weight. And also, I do feel it's a very fragile truce I have at the moment. I feel like I have to trick myself. I have to check. So little tricks I have is to check what's for breakfast the next day in the program, the night, the day before, just so that I can, every day I'm making that decision. Today I'm going to follow it. If I don't, I can fall back into old habits, but Brad, I had the doctor say to me it can take two years for the body to stop wanting to sabotage yourself. And so that really helped me as well because I thought, okay, if I can get up to two years, I've still got to remain vigilant. I had a mantra, be vigilant because losing that weight was my last chance. I felt if I put the weight back on this time, I'd never take it back off again.  James Valentine: That's interesting, isn't it? Like that I wouldn't have really known that because I think most of us think I'll lose 10kg and then I'll be fine.  Brad: Yeah. I suppose the thing is there's no magic number as well. So, I'm not sure whether that doctor's coming up with two years for it is often like a longer term sort of like hunger and a drive for food. It's a very primitive reaction. There is some sort of changes. So, if you have been eating a lot and then you have been eating less, then your stomach will shrink a little bit over time. And so, if you're having food, your stomach will stretch earlier and so you'll feel fuller quicker. So that may be what they were talking about. But yeah, your body wants to sabotage you forever. Sorry, Jacqui. It wants to sabotage all of us.  James Valentine: But does your appetite sort of change? I mean, like I want pizza. I want chips. I want pies. I want cake. If you change it, does it just take a few years for you to start to, I want salad. I want tomatoes.  Brad: So, a lot of my patients will find that, yeah, if they're, if they're on a diet, if they change their diet, they will often continue to have this voice, this hunger, telling them to go to the fridge and telling them about the foods that their body is craving for. So and I think that that voice diminishes a little bit over time, but it's still going to be there.  James Valentine: Jacqui's superpower is she changed her whole appetite?  Jacqui: Well, gosh, like I said, it's quite, I know it's fragile. I know I can, I just went into the fridge the other night and had a little binge. Just the stress, you know, but I have to think, no, go back on it the next day, back on it the next day. James Valentine: Yeah, it's a beautiful description. You've used a fragile truce, isn't it? And I'm sure a lot of people with addiction would feel a similar sort of thing. And there'd be lots of aspects of our life where we have a fragile truce.  Jacqui: Yeah, I do feel like it's been a little bit of an addiction over the years, the eating, you know, it has been that thing I've used, I think, to comfort myself, not very healthily. So, yeah, I'm definitely, I've got that vigilant, be vigilant in my head for sure. That's what I do.  James Valentine: Yeah. And let's go back, Brad, to the motivation, the fact that this, you know, Jacqui conceived of this Everest, climbing Everest-type desire. That's powerful, isn't it?  Brad: Yeah. So, I suppose one thing that I'd be wanting to mention is that people can be motivated, they can be driven, and they have every aspiration of reaching their goals. And then often, they aren't able to do that. Their metabolism works against them, their hormones work against them, their body. works against them. And they will often feel like a failure. And I think this is just this horrible sort of occurrence that just permeates throughout the world. We often have a stigma towards obesity and people being overweight. And we often blame people for just putting things in their mouth. But it's not people's fault that they're gaining weight. And it's not their fault if they can't lose weight. There are just so many other factors involved with it. And we try to simplify this as people and our understanding of it. We try to put it in a box. And so, yeah, it's just a reminder that if Jacqui has got the motivation and drive and has some tools in her belt that she can use to get to that level, and she's happy with her weight and where things are at, that is amazing. That is fantastic. But yeah, some people aren't that lucky. They aren't that fortunate and there are, and it's not their fault if they can't reach it. James Valentine: Yeah. Did you feel those kinds of things that Brad was describing there, Jacqui? And, and I'm wondering, do you necessarily feel a victory or an elation now?  Jacqui: No, I mean, certainly sometimes when I put some clothes on and I am pleased, you know, that I'm thinner than I was, but one of the things I think, absolutely what Brad said.  My message would never be to shame someone. I never wanted like a before and after photo, for instance, because I've seen them all. I've seen those photos on TV or the magazines.  Brad: They just changed the lighting, Jacqui.  Jacqui: Because I've, you know, inverted commas here, but I feel like I've failed so many times because and that's, I guess, part of the fragile truce. Now, you know, I feel like I could, I don't know how to word it properly, but I suppose go backwards and, I never want anyone to feel that, you know, I've got it sorted because I'd be the last person to say that. If I had it sorted, I would have 40 years ago.  James Valentine: Yeah. Well, I almost wonder where there's a sort of like an almost reverse thing if you, if you're feeling great now and everyone's complimenting you now, it almost sort of, it doubles, the shame of the past.  Jacqui: Or the pressure to, to keep it off.  James Valentine: Or the pressure of it. Or sort of like, oh, so that's, it is, everybody is just sort of incredibly admiring of skinny. There is only skinny, you know, that sort of, that sort of thing is wrong too, isn't it?  Brad: It's a great way to force an eating disorder. James Valentine: Yeah. A great way to force an eating disorder. Let's consider age as a factor in here, Jacqui's done this at 60, which is pretty impressive, you know, I've barely got the motivation to do anything anymore, really. So the, is it, is it harder, is it physically harder to be losing weight, and I suppose a big factor of that will be a psychological thing. Mate, why am I bothering? This is me now. You know, come on, you know, let me enjoy myself. Really? What have I got to gain? You know.  Brad: I think it's, it's also mobility. And so over time we accumulate problems, we develop injuries. And so, it gets harder and harder to move. Our heart doesn't work as well as what it did when we were a teenager. So, we can't quite get to that level of exercise, yeah, that endurance, that ability to go all of the yards that we're needing to, to exercise enough to bring down our weight.  James Valentine: But we can do diet.  Brad: We can do diet. But again, it can be very, very restrictive.  James Valentine: Yeah. Do we talk about it incorrectly, really? We should be talking about how hard it is, not, we've got this easy one fix. Try this diet. Come to my bootcamp. We'll be able to, able to fix everything.  Brad: I think in medicine we are trying to change that narrative for decades. So, trying to talk about like healthy eating habits and, yeah.  Trying to teach teenagers, uh, which foods to eat so they won't end up overweight or obese over their, over their life. So, I think our way of changing with television, with the media, and trying not to stigmatise people for their weight as well. This is sort of like a weird conversation that's going on right at the moment.  Not fat shaming people, and people are talking about like being fat fit where they may be overweight, but they're actually like healthier than what I am at the moment.They can run a marathon. I couldn't do that at the moment.  James Valentine: Yeah. It's worth underlying that, isn't it? Because that's a reasonably recent change. We've gone from a sort of sense that we've got to point out to these fat people that they need to lose that weight because it's no good for them. You know, your heart's struggling, you'll get diabetes. We've changed, we've changed, that attitude's changed considerably. Brad: I think it's a real interesting time at the moment. We've gone from fat shaming to now being like fat fit and body positive. And now with the introductions of a range of different medications that are all coming around the world, which are enabling people to lose more than that five percent that they could do under their own steam, getting down to 10, 15%. Some of the medications that are coming around the corner could get even up to 25% loss of your body mass. This is sort of like disconnecting people's relationship with food. It's allowing them to change their body type. And I'm really sort of intrigued to see what happens with the social discourse and social understanding of that as we've gone from body acceptance, and this is how it is, to oh well, they're a skinny bitch because they've been using this drug. James Valentine: Yeah. Are you supportive of the Ozempic Revolution? I guess it's one of the brands that people might be more aware of than others.  Does that seem like a good thing to you?  Brad: Overwhelmingly, it's positive. So having one injection a week is suitable for a lot of people. But it's not just about the weight loss. Like, some people look better and that's what they're going for, fine. But if you're losing like 10 percent of your body mass, then it's going to decrease your risk of high blood pressure, decrease your risk of diabetes, decrease your risk of heart attacks, other heart disease. Decrease strokes, also decreases your risk of getting a whole bunch of cancers that are related to obesity and being overweight too. So, it's overwhelmingly, this is, yeah, a good, a good thing around the world.  James Valentine: Yeah. Jacqui, if that sort of thing had been available through the years or now, do you subscribe to that? Would you be happy with that?  Jacqui: Very tricky. I'm not, I'm not actually sure. I mean, I was so reluctant to go on medication of any kind. I always wanted to try, if I was going to lose weight to try and do it, I suppose, inverted commas again, naturally. Because I, but I mean, Brad's absolutely right. I mean, I don't know everyone's metabolism, like everyone struggles in their own way with these things.  But certainly in terms of what Brad was saying, I think for me, I was so pleased to come back from Costa Rica and the doctor ran the blood tests again and I was not prediabetic anymore. So certainly, in terms of losing weight, it certainly helped my health prognosis, I would say. My heart blood pressure, high blood pressure medication went down by half as well. I'm still on those tablets just because we have a history of family heart disease, heart disease in the family. But, in terms of losing weight, it did actually have some health benefits, absolutely.  James Valentine: Well, when we left Jacqui, she was about to embark on a flight to Costa Rica to save the turtle population of the beach there. Jacqui, pick us up with the adventure. What happened? What happened when you got there? Could you do the walk?  Jacqui: So, yes, for all their kind of, you know, you need to be able to walk four to five hours every night, 10 to 12 kilometres on soft sand on the black beaches of Costa Rica on the Caribbean coast.  Yeah, we didn't actually go out every single night, so I could get some rest time in between. And most of the nights, we would walk for a while, for sure, there was a lot of walking, but then we'd stop and work a turtle, which means we'd get in the pit with the turtle, we'd measure it, we'd body check it, we'd go under the turtles to catch the eggs and count them.  So, the physicality was the walking, but also getting in the nest with this very big base, trying not to get sand flipped everywhere by their very strong flippers. James Valentine: So, you were the Steve Irwin of turtles at this point. You're Crikey! Look at this, look at this fella. Describe the turtles. What species are they and what do they look like? Jacqui: So, this is the second largest in the world, Australia has the largest, but, largest in the Western Hemisphere of endangered green sea turtles. This is their nesting beach, so peak season they were coming up onto the beach and laying their eggs. They're quite fascinating creatures.  James Valentine: And how many, like in the thousands? Jacqui: Oh yes, could be in a whole season, even tens of thousands, yes. But obviously they have their perils, I mean they are endangered, and human predation has a lot to do with that.  James Valentine: And so, is that what the task was, was mainly to protect them from things like that or?  Jacqui: So, it's collecting data for Sea Turtle Conservancy in Costa Rica. That was the organization I went with.  James Valentine: And did you turn out to be, was it a bunch of sort of slim young gap-year type people who were running around doing this and you?  Jacqui: Yes, yeah. But there was one lady who, accidentally, I didn't know, and it was just random that she was there at the same time who was about my age. So, I was very fortunate how that worked out, but the young people were wonderful. They took me under their wing, and they made me feel like I was their mama for sure. They were lovely.  James Valentine: And as like you were so motivated to go and do this, this obviously turned into sort of like, this is a journey that I really want to make. This is my dream sort of adventure to go and do this.  Jacqui: It was life changing in so many ways. I think just, I mean, the young people were so inspiring, their love of conservation, their love of nature, the willingness to kind of be involved in something like that for months at a time. But obviously in terms of my weight and my fitness and my breadth of understanding about the world, I never, didn't even really know where Costa Rica was before I went. James Valentine: What's next? Because having conquered that, it sort of feels like, well, what can I take on now?  Jacqui: Well, yes, that's right. We did spend a little bit of time in Spain and discovered hill walking, which is very good for the fitness as well. And then, hopefully maybe India at the end of this year, but we'll see how we go. James Valentine: Fantastic. Brad, I'm inspired. You know, like I sort of feel a little bit ashamed. I sort of think, oh, I wouldn't mind a house down the South coast for a while. That could be good.  Brad: Are you training for cheetah conservation?  James Valentine: Yeah, cheetah conservation. You need to chase down a cheetah and just inject it for a moment. James Valentine: Just measure its fore paw and then, you know.  Brad: Work it up. Count its eggs.  James Valentine: Yeah. Have you got anything like that? Or do you have a sort of dream journey or something like that that you'd love to do? Brad: I'm a bit of a veteran at Burning Man, so I often, yeah, like, pack up my stuff and then go into the middle of the desert and try to make sure that I'm fit enough to survive in Nevada with very little resources. James Valentine: Were you there for the big muddy one this year?  Brad: I was trapped in the mud.  James Valentine: Really?  Brad: For quite a few days, yes. James Valentine: Oh, that's a very good annual adventure. And I think your weight might be a little crucial there too.  Brad: You lose a few kilograms, yeah. When you're struggling through, through muddy sand. James Valentine: Well look, fantastic. Great conversation. Thank you so much for, you know, Jacqui, thank you so much for sharing so much there. That's a very personal story that you've revealed for us. And thank you so much.  Jacqui: Thank you very much indeed, for the honour.  James Valentine: Brad, thanks for your expertise. Brad: Thanks for having me. James Valentine: For more about Jacqui Hodder and her weight loss journey, you can read her book. It's called Turtling in Tortuguero. And Dr Brad McKay's got a book out as well, it's called Fake Medicine. You'll see the links in the show notes, you'll find them in bookstores and libraries right now. I think you'll agree, great story from Jackie and terrific information from Brad.  You've been listening to Life's Booming, Is This Normal? Please leave a review or tell somebody all about the show. If you want to know more, head to seniors. com.au/podcast. You'll get our earlier series there and more episodes. I'm James Valentine. I'll see you next time for another Life's Booming.    Tortuguero! Turtling in Tortuguerro! I love just dropping into accent for one word, it's always very powerful. Okay.See omnystudio.com/listener for privacy information.

As the new year unfolds, resolutions often falter, particularly those related to food habits. Acknowledge this truth with gravitas—most diets fail most of the time. Neuroscientist Dr. Jud Brewer challenges conventional weight loss wisdom, exposing the myth of willpower from a neuroscience perspective. In his third podcast appearance (RRP episodes 471 and 586), Dr. Brewer, Brown University's Mindfulness Center director and School of Public Health and Psychiatry professor, delves into his latest book, The Hunger Habit. Drawing on two decades with thousands of patients, he advocates attention, mindfulness, and curiosity for healthier choices. Evolutionarily, our brains, seeking certainty, create habit loops with triggers, behaviors, and results. The reinforcing dopamine spritz forms a stubbornly resistant, recalcitrant loop. Dr. Brewer scientifically addresses breaking these habits. Today, we explore the neuroscience of habits, dopamine's role, the absence of willpower in behavior change, and the importance of self-acceptance. Note: This discussion may be confronting for those with eating disorders; seek help at www.nationaleatingdisorders.org. Dr. Brewer's blend of Eastern traditions and hard science provides practical solutions. This episode is a must-listen if you're wrestling with cravings or food compulsions. Show notes + MORE Watch on YouTube Newsletter Sign-Up Today's Sponsors: SEED: Enjoy 25% OFF

In this episode, Lindsay discusses the importance of handling newborns with care and gentleness. She shares her concern about a viral video circling social media where a nurse was handling a baby roughly, causing the baby to show signs of stress. Lindsay emphasizes that newborns have never been touched before and are programmed by evolution to expect only their Mother's touch. She questions the justification and normalization of rough handling in hospitals and highlights the importance of imprinting and bonding between Mother and baby. Lindsay encourages parents to advocate for their babies and demand gentle handling during the newborn period.Key Takeaways:Newborns have never been touched before and expect only their mother's touch.Rough handling of newborns can cause stress and disrupt bonding.Imprinting and bonding between mother and baby are crucial for the baby's well-being.Mothers have the right to refuse or limit the handling of their babies in hospitals.Gentle handling of newborns is possible and should be prioritized.Quotes:"Evolutionarily speaking, newborns are expecting to be touched only by their mother.""Just because something is normal doesn't mean it's right.""Mothers have a unique connection with their babies that no healthcare professional can replicate.""Protecting your baby is a parent's job. You don't have to tolerate things that cause stress.""Newborn exams can be done while a Mother holds her baby. It's possible and beneficial."Questions?Looking for further support during pregnancy?Reach out at join@birthlikeamammal.com for birth support and other resources. Find us on: Website Instagram TikTok Music Credit: Snow Path by Vlad Gluschenko | https://soundcloud.com/vgl9Creative Commons / Attribution 3.0 Unported License (CC BY 3.0)https://creativecommons.org/licenses/by/3.0/deed.en_USEdited by: Stefanie Wenninger | Pine Peak Productions

Episode 74: The Power of Human Connection in Ending Burnout   Join Dr. Prianca Naik on the Empowering Working Moms Podcast! In this episode, she talks about how powerful human connection is when it comes to getting rid of burnout. Dr. Prianca invites you to learn about how you can improve several aspects of your life through connecting with those around you. Tune in for more on this important topic.   In this episode, you will learn: The role of relationships in our mental well-being. The evolutionary context of the concept of tribe. The rewards of social connection. How to build and maintain connections.   To end burnout and exhaustion and get your peace of mind back, check out her free masterclass on 4 steps to overcome burnout, get rid of overwhelm, and get your peace of mind back. https://program.stresscleansemd.com/4-secrets-to-living-a-life-you-ll-love-podcast   If you want to work with Coach Prianca Naik, MD, go to www.priancanaikmdcoaching.as.me to book a 30-minute consultation call.   Sign up for this powerful vision breakthrough today…a limited time offer until the end of this year: https://buy.stripe.com/cN22c8cWH4Aq0KsdQT   Follow Dr. Prianca on social media:   https://www.facebook.com/prianca.naik   https://www.instagram.com/doctorprianca   https://www.linkedin.com/in/prianca-naik-md-0524a196/   Join her FREE Facebook group:   https://www.facebook.com/groups/646992382603860   [FULL TRANSCRIPTION:]   You're listening to the empowering working moms podcast episode number 74. Hello there, I am so happy to have you here today listening to this week's podcast episode. I hope you're doing well, I have been doing great.   And I say that because life is often in phases of up and down, or maybe just sometimes middle ground. And I have been in a middle ground to up meaning better place, at least right now. And I attribute that to having seen some old friends recently. And I've also been in the process of making new friends in the community and also at my older child's school.   So that's been really nice and has me thinking about the power of human connection. So many of us as moms out there, you've got the demanding career, and you're just exhausted. And maybe you find yourself yelling at your kids twice a day to get out the door and brush their teeth. Or you've thought about cutting back at work for a really long time or a different role, but you're afraid to ask for that because of what your colleagues or superiors might think.   Or every day your brain is just spinning nonstop over your to do list or pending work that's piling up. And this is mentally exhausting, and it leads to exhaustion and burnout. And what I do in my program, and I'm going to talk about today, it's really solutions to ditch burnout and exhaustion once and for all. And if you want to learn more about that check out my free masterclass four steps to overcoming burnout and overwhelm to get your peace of mind back. The link will be in the show notes.   And in terms of solving it, today, we're going to dive into the concept of human connection and how powerful it is. So let's just start with creating an understanding of the impact that relationships and connection have on our well being. Studies have shown that strong healthy relationships are linked to better mental and physical health, along with having a reliable support system. And this can truly improve emotional health, well being, resilience, and most importantly, it fulfills the need to belong.   So for us, having a sense of belonging as human beings is such a key component for leading a balanced life. And we really are inherently social creatures. Evolutionarily, the survival and success of the human species has heavily depended on our ability to form strong bonds. So in prehistoric times, early on, early humans found support and also resources within the framework of tribes or close knit social groups.   Which is why we always talk about, I think there's a common idea that having a sense of tribe is so important. Now back then those tribes provided protection against external threats like predators, and also helped with the success of hunting and gathering and feeding families. And the tribe would share these responsibilities and resources. And therefore the burden was no longer on one person. And that really helped them survive.   So this is how humans evolutionarily really thrive in cooperative and interconnected communities. Now, today, it's a little different, especially in the United States. People tend to often stick to themselves, they don't ask for help, houses often are not as close together. And I say this because I remember when my grandmother was alive, when she would come to visit us from India, she would feel so lonely, because the juxtaposition of living in America where everything's kind of quiet, you're on your own a lot.   She was used to living in an apartment in India, where neighbors would just drop by unannounced and she was constantly socializing. So that gives me a little bit of a comparison of how maybe other countries might function. I know that's how India is, people are much more social. But in this country, people don't always have this automatic community. And that's where the work comes in. And we get to decide that we can create one, we build one.   So our brains have evolved to reward us for social interactions as well, because positive social connection really triggers the release of oxytocin. And oxytocin is a hormone that really fosters trust and bonding. And that's why spending time with loved ones and belonging and being a part of a community.   For me, that's my college group of friends, my medical school group of friends, a couple of residency friends, I'm close with too, although currently I'm really working on building the community where I live and trying to make new mom friends. Which is why I'm bringing this up because I want everyone to have this at the forefront of their mind. Forming strong relationships is just rewarding. And it really has been through human history for the reasons I just described.   So when we have a tribe, a group of friends or a supportive community, we have a place to turn when life gets overwhelming or we're having a hard time and hopefully you build a community with people who you trust, who can have empathy for you and you for them. And who can understand what your struggles might be, and make you feel like you have people to lean on. And that connection is such a great tool, a safety net, and can help us navigate the challenging aspects of being a working mom, a mom in a demanding career.   Where you're doing so much at work, and you're so busy. And then at home, you're also perhaps having the majority of the mental and physical labor at home as well. The other thing I didn't mention before, which I should have is that early on humans and tribes, they actually experienced less stress, because they had this sense of belonging and emotional support, and that contributed to their overall survival, but also reproductive success as well.   I'm going to briefly break down the types of connection that human beings can have. So you got familial, friendships, and romantic. So we've got those types of connection. And what's interesting is there are a lot of preconceived notions about family where you feel like you're supposed to be the closest with your family. But sometimes, depending on how much personal growth you yourself do, you can start realizing maybe things that don't align for you that your family demonstrated, or the practices that your family had.   Or maybe that your family is not supportive in certain ways, and maybe they don't meet your needs in certain areas. And as you do that, connection with others becomes that much more crucial and critical. So friends, for example, fostering those friendships can really be grounding and help you during good times and bad.   And I think I said this on last week's episode, that people are often caught up with their own stuff. But if you actually reach out to your friends and tell them that you need them, more often than not, as long as they themselves, if they're going through a hard time, they're not gonna be able to show up for you. But most of the time, people will turn up for you, you just have to ask.   And of course, fostering that connection, in general is really important, be it through text messages, or sending cards, or sending a gift, or that you're thinking about them, or calling people. That's really important in maintaining the friendships throughout.   And then we've got romantic relationships, which especially if you're married, or have a partner, and you live with them, that's a day to day interaction that is one of the most important relationships of all. Because that's the person, especially if you have a lifelong commitment with them, that you're going to be with even after your kids leave the house, after your parents pass away. So that one probably needs the most attention and take that for granted the least.   And so also you have to figure out ways to connect with your partner on a daily basis in person, know their love language, really foster that and work on good communication skills.   And actually beyond that, and I'm not a relationship coach, but something that I've really come to know is that knowing who you are, where you came from, your emotional history, your baggage, why you made the decisions you've made, how you got here, and really knowing yourself and loving yourself, that is critical in building a relationship and a connection with a romantic partner. And hopefully they do the same. And then it makes it a little easier to create a connection between the two of you.   So those are the types of connections and then also we've got superficial versus more intimate connections. So superficial conversation is just conversations that you have with people that you don't know, like the weather, or what trips are you taking, but things that do not really scratch beyond the surface. And I personally am not interested in doing that in my life anymore, I just find it to be not rewarding. And I feel like it's a waste of my time.   And if I'm going to make friends with people, I really want to scratch beyond the surface and delve a little bit deeper than that. I mean, you can't really do that right away with people you don't know. But me personally, I'm pretty open. So I will usually be honest about my situation.   And with a little bit of vulnerability, I think that welcomes people to be vulnerable as well. And granted, you don't have to overshare but if you're comfortable sharing below surface stuff, I think that's always useful in initiating a little bit more intimate of a conversation, intimate of a connection that's beyond the superficial, because that's really how we create those bonds.   So now I'm going to talk a little bit about maintaining and improving these relationships. So I've got about seven tips to talk about today.   Tip number one is really prioritizing communication. So this is really wonderful and not easy to do to have real conversations. Really sharing our honest thoughts and feelings while practicing kindness at the same time. And this is truly the foundation of any strong relationship.   And I actually really like the Gottman Institute for little tips and tricks. It's on romantic relationships, but I also think it's applicable to other parts of our lives. Including conversations with our children, where communicating with kids and really having those lines of communication, a judgment free zone and somewhere where the kids feel safe to talk to us. That's really critical in the bond with our children as well.   Tip number two, quality time. So really making time to spend with the people that you care about. So be it trips, my college group of friends has a yearly trip, same usually my med school group of friends, we meet yearly. And with other friends, I try to make time to talk them on the phone regularly or see them.   If you've got a partner really plan those date nights automatic, schedule them, have playdates for your kids with friends, and try to be present when you're at home with your family and put your phone away because that is quality time and our kids will be gone before we know it. So really being present in these moments can strengthen that connection with others.   Tip number three is practicing empathy and understanding. So just the idea that everyone has their own struggles, so we just never know what's going on with other people. So really try and put yourself in the shoes of your partner or friends or family and try and have empathy for them. Because this can really lead to better connection as well.   And if you show up empathetically for someone else, don't expect anything in return. But oftentimes people will surprise you. And they will support you in an empathetic way. And you will receive that well.   Tip number four, boundaries. They're healthy. So learning boundaries is so important. And boundaries really look like if you do this, then I will do that. So it's not about shutting other people down. It's really protecting our own personal space and our needs.   And so I'll give an example of this, which is interesting. And it's come up for me recently. I realized that one of my personal triggers is when people raise their voices or when they're yelling. And one of my children has taken to shouting from time to time. So I told my child, hey, can you please stop shouting, and my child didn't listen. So then I said, hey, if you keep shouting, I'm going to have to remove myself from the room for a moment because I'm not enjoying it, and I gotta leave the room.   And I set that boundary. If you do this, then I'll do that. That's how boundaries work. And I found that the shouting stopped right away, and I didn't have to leave the room.   So it's really interesting when we can communicate our needs and have a plan in place for ourselves for our own mental and physical safety, given whatever scenario you want to plug into that.   And boundaries in preserving our personal safety and space really help to energize us and reduce exhaustion and prevent burnout, it leads to better connection and better and healthier relationships, actually. And remember that the people who really love and care about you, they're not gonna be mad at you if you practice boundaries for yourself.   Tip number five is gratitude practice. I love this one because gratitude is known as something that really boosts happiness. Research has shown that gratitude practice really leads to a happier life. And so taking time every day to reflect on the positive aspects of our lives, having gratitude for the people in our lives, having gratitude for the relationships.   Really telling ourselves how grateful we are for things, that's important to really acknowledge that. But also expressing gratitude for others. And I think it's so important to let those who we care about know that while they're still around, and hopefully that way, we won't have regrets.   And so practicing gratitude can definitely strengthen the connection between us and others, really strengthen that bond and have a positive ripple effect just all around. That's one of my favorite things to practice, because it's just so easy to do.   And I've probably mentioned this before, but I've been practicing gratitude with my older child since he was two and a half. And now he's five and now my younger daughter, she is two and a half. So I just started practicing with her too.   Tip number six is to seek help when you need it. So don't be afraid to ask for help when you're going through a challenging time, fom your partner or friends or whomever else. Really sharing your struggles can help you feel better, but also help others have a better understanding of where you are. And that leads to strengthening of relationships as well.   Last but not least, tip number seven is to celebrate. And this is one of my favorites. This is not as easy to practice as gratitude. But this is one of my favorite things to do celebrate everything, whether it's a personal achievement, an anniversary, a special occasion, a birthday, whatever it is.   Getting people together for these milestones, and really creating memories to reinforce the joy of life. And also you'll see that when people show up for you during these special occasions, it strengthens the bond, it strengthens the relationship, and you're going to feel really, really loved and cared for.   And me personally, a shout out to all my friends, particularly the ones who have shown up to celebrate with me some of the big moments in my life and they have taken a lot of trouble to do that and my sister too actually. So I love and care for them very deeply and it has meant so much to me that they've been there for me.   And so taking the time to do the celebration and celebrate really each other and each other's success, each other's growth. And I remember a good friend of mine from medical school, a dear, dear friend, she and I were talking on the phone and we were both celebrating each other's progress in life.   And it was just nice to cheer each other on for the mundane things. Because I think often we just take that for granted. But that's another way to really deepen your connection with other people.   And now I'm just gonna talk about a couple of client examples. I have of really strengthening connection and relationships. One of my clients who is a physician and mother of two small kids, she started incorporating her older child, her daughter, into her morning routine of just making her coffee and having her help with stuff in the morning.   Now, this served a couple of different purposes. Her daughter felt important, she felt like she was connecting with her mom. And the client was also getting some help in the morning. So it just ended up everybody was winning.   But she felt like through creating a couple very simple rituals with her child, she was able to foster a deeper connection, and she found her child acting out a lot less when she was doing that. So that's something to think about doing. Especially if you have younger kids, they love being involved in mundane activities.   Another one of my clients, who is a pharmaceutical executive and mom of two, she took time to start playing the guitar again. And what she ended up doing was she ended up taking guitar lessons with her daughter. So that was their special thing that they were doing together. And she was able to really connect with her daughter and reignite her old hobby and make time for herself through practicing the guitar.   And now I'll give you one of my own personal hacks. If my son has like a half day off from school, I try to do something with him. Be it spend time with him, run errands with him, get a meal with him, just so that we get in some quality time on a regular basis. And this is in addition to whatever day to day practices that we have like the gratitude practice or storytime or he's playing the ukulele now, he just started but I sit with him when he practices that.   Because for me, academics and being disciplined are really my strong suits so I can show up for my kids in that way. Emotional intelligence is also something I'm really interested in. So we talk a lot about mindset and the ways we see the world. And we do a lot of practicing breathing for, let's say having coping skills and tools in our toolbox for any and all emotions, which are all okay to feel.   So those are specific examples of my clients and me and what we've done. And I'll also add that I know a lot of you are probably thinking that cutting back work to part time is the best way to be a good mom and spend time with your kids.   Well, that's not the only way to be a better mother and connect with your children. And it's okay that you think that because society has been implying for years that we have to work part time even schools don't really cater events and scheduling to working moms. But if you've fallen in that trap, I'm willing to bet that you've been feeling guilty too for a while.   So we know that if working part time made us feel less mom guilt and created better parents then everyone who worked part time would be totally fulfilled and satisfied as a parent. And we know that's not the case.   So here's what the women who are fulfilled and happy career moms, what they do. They create rituals in the morning of a minute of snuggle time or having their child participate in making their morning coffee like my client did, or putting your phone away when you walk in the door for an hour to really connect and inquire about your kid's day.   Or have a mindfulness based practice every night before bed like gratitude practice or belly breathing for about a minute or so with your kids like we talked about. So that gives you plenty of stuff to think about today. When we die, we're going to remember the connections we made with our friends and family, those memories and those moments. Not being at the computer for our job, putting more time and energy into work. That is not what we're going to remember.   And I say that as a physician who does a lot of end of life care. I've been a hospice medical director and for sure the work stuff doesn't matter as much as we think it does. And the day to day grind, it's so easy to get caught up in that, especially when you have kids.   But really being able to zoom out and think about what we talked about on today's episode, the power of human connection and how not only is it so, so important but it really will help us combat exhaustion. And I've helped so many professional moms work on these kinds of issues and fix this problem through coaching with me.   So to see if you are someone that I can help too, click on my scheduling link. The link is in the show notes, www.PriancaNaikMDcoaching.as.me. Thank you so much for listening today and I will talk to you next week.

Guest Segment  Shawn Stevenson is a Bestselling Author, Speaker, Nutritionist & Strength Coach, who joins the show for the third time to discuss his most recent research on the observable impact of communal eating on overall health.  Shawn Stevenson's third guest appearance on Heal Thy Self  Is eating together in community essential for our long term health?  Culture guides our eating habits Children who eat with family regularly get more nutrients  Families who eat together consume more fruits and vegetables Eating together prevents chronic disease onset in kids  Evolutionarily people ate as a group  Relationships impact our health  WHY does community have such a large impact?  Planning and scheduling  Family time relieves stress  Human Energetic fields & community What is the biggest thing that is preventing us from eating with family? Creating a micro-culture within your household  Ultra-processed foods in our culture  Bringing your family's culture with you  Our metabolic response to food is affected by artificial flavor profiles  Whole Food based diets  Becoming addicted to our association with screens while eating  The importance of gratitude practices  Making your table a sacred space  Phones being nearby impacts our ability to focus  How to implement better dinner habits  Find what motivates your family and integrate it into your habits Ads Birch  Thank you Birch Living for sponsoring! Click here https://www.birchliving.com/HEALTHYSELF to get 27% off your Birch mattress (plus two free Eco-Rest pillows!). Offer expires at the end of the month. #birchliving NED Discover how Shuteye Chai can revolutionize your sleep and get 15% off with code DRG. Go to https://www.helloned.com/DRG or enter code DRG at checkout. Biotimizers  To get your free bottle just go to https://www. magbreakthrough.com/drgfree and enter coupon code drg10 Learn more about your ad choices. Visit megaphone.fm/adchoices

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.19.549681v1?rss=1 Authors: Gutierrez-Barragan, D., Ramirez, J. S. B., Panzeri, S., Xu, T., Gozzi, A. Abstract: Evolutionarily relevant networks have been previously described in several mammalian species using time-averaged analyses of fMRI time-series. However, fMRI network activity is highly dynamic and continually evolves over timescales of seconds. Whether the dynamic principles that govern intrinsic fMRI network fluctuations are conserved across mammalian species remains unclear. Using frame-wise clustering of fMRI time-series, we find that fMRI network dynamics in awake macaques and humans is characterized by recurrent transitions between a set of 4 dominant, neuroanatomically homologous fMRI coactivation modes (C-modes), three of which are also plausibly represented in the rodent brain. Importantly, in all species the identified C-modes exhibit species-invariant dynamic features, including intrinsic infraslow dynamics and preferred occurrence at specific phases of global fMRI signal fluctuations. Moreover, C-modes occurrence rates in awake humans, macaques and mice reflect temporal trajectories of least energy and predicts ranking of corresponding functional connectivity gradients. Our results reveal a set of species-invariant principles underlying the dynamic organization of fMRI networks in mammalian species, and offer novel opportunities to relate fMRI network findings across the phylogenetic tree. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

I recently finished the library copy of Big Magic by Elizabeth Gilbert - who you may know from Eat, Pray, Love fame - and if I'm honest I read it in college ish and was not a fan. I judged her hard, and because of it - I avoided content until recently when clips of her offering incredibly insightful thoughts I decided to give her new book - the one she was often promoting with these interviews - a shot. The book is Big Magic. And it's a fairly short read about creative living and as is always the case with self-help type books, I have a few notes, but overall the book was really lovely and made me think - which is really all you can ask for in a book. It's a book I'm sure I'll return to - and may even buy for my own shelf eventually, because it's about the spark + realigning with it - which as a creative, is a necessary part of the process every once in a while. This book doesn't define creativity as pursuing a life that is exclusively or professionally devoted to the arts, rather it's written as a manual with universal aspirations and provides lessons in how to unleash your creativity.Here are my favorite insights from the book - On fear: If you pass your hand over a petri dish containing a tadpole, the tadpole will flinch beneath your shadow. That tadpole cannot write poetry, and it cannot sing, and it will never know love or jealousy or triumph, and it has a brain the size of a punctuation mark, but it damn sure knows how to be afraid of the unknown. Well so do I, so do we all but theres nothing particularly compelling about that. Theres no extra credit for being afraid of the unknown. Fear is a deeply ancient instinct. Evolutionarily vital. But it aint especially “smart”. RESOURCES: https://www.irishtimes.com/life-and-style/people/elizabeth-gilbert-when-a-magical-idea-comes-knocking-you-have-three-options-1.2474157WATCH: www.youtube.com/juliemericaGET A MONTHLY NOTE FROM ME: www.makeyourdamnbedpodcast.comTUNE IN ON INSTAGRAM FOR COOL CONTENT: www.instagram.com/mydbpodcastOR BE A REAL GEM + TUNE IN ON PATREON: www.patreon.com/MYDBpodcastThe opinions expressed by Julie Merica and Make Your Damn Bed Podcast are intended for entertainment purposes only. Make Your Damn Bed podcast is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Get bonus content on PatreonSupport this show http://supporter.acast.com/make-your-damn-bed. Hosted on Acast. See acast.com/privacy for more information.

Today, I am blessed to have here with me Dr. Courtney Hunt. She attended the University of California at Berkeley for her undergraduate studies and continued her education at Loyola School of Medicine in Chicago, Illinois.  She completed her Obstetrics and Gynecology residency at UCLA. Dr. Hunt practiced obstetrics and gynecology for 15 years before stopping obstetrics to pursue her interest in quantum biology and nutrigenetics or the interaction between our environment and our DNA. Dr. Hunt began investigating the intersection between the physics of light, mitochondria, and DNA to determine the best practices and methods to keep us healthy.  She has successfully treated patients with complex and chronic issues, she has developed integrative protocols to address a variety of illnesses that include thyroid and hormone balancing, nutritional genetics, and mitochondrial function assessment. She also believes in the optimization of human potential for the individual, our families, our communities, and society. The mission is love, and when we all learn to heal inflammation one by one that is when we come to work together for the good of humanity. In this episode, Dr. Hunt opens the show by explaining why healing your body through sunlight and nutrition should be more mainstream. Then, Dr. Hunt dives into how the energy from the sun is everything, and it feeds all forms of life on this planet. If you aren't getting your daily dose of sunlight, your body won't naturally heal itself. Plus, Dr. Hunt reveals the real reason autism rates are increasing globally. Tune in as we chat about improving vitamin D levels, why we have a mental health crisis, and the importance of lowering inflammation in the brain.  JOIN MY 90 DAY HEAVY METALS DETOX PROGRAM (11 SPOTS LEFT): HTTP://WWW.KETOKAMPDETOX.COM  Order Keto Flex: http://www.ketoflexbook.com ------------------------------------------------------ / / E P I S O D E   S P ON S O R S  Biotiquest Sugar Shift product. Regulate glucose, reduce cravings, achieve deeper ketosis, and remove glyphaste.  https://biotiquest.com/products/sugar-shift Use the coupon code KAMP10 for 10% off their products.  Get Bioptimizers Magnesium Breakthrough for the best night of sleep, ever! Nurture your mind and body with this all-natural, full-spectrum magnesium supplement. Visit www.magbreakthrough.com/ketokamp and use code ketokamp10 for 10% off.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [00:50] Fixing Problems With Nutrition Should Become More Mainstream  Dr. Hunt had two children back to back. At one point, Dr. Hunt could barely read; she realized that she was losing her cognition.  After doing research, Dr. Hunt realized a massive problem with her patients and their nutrition. To solve problems, you have to look at the symptoms and figure out what foods or supplements will help build better cells.  [07:10] Energy Is Everything: How The Sun Can Help Heal Your Body The sun in the sky is in thermodynamic equilibrium with Earth. The light in the sun gives us all the energy to grow plants and for the plants to perform photosynthesis.  Those plants are cleaning our environment and making oxygen for us to breathe, and we are burning the oxygen as fuel.  When you understand electromagnetic radiation, it is frequencies of energy. The energy from the sun is feeding animals, plants, and humans.  All information comes from sunlight either, directly or indirectly.  [10:20] Should You Go Outside and Get More Sunshine Today?  You should be outside no matter where you live. Also, be cognizant of your skin type. Dr. Hunt recommends getting the D Minder App: https://apps.apple.com/us/app/d-minder-pro/id547102495 You need just the right amount of sunlight.  Don't scroll on Instagram all day; instead, play with the D Minder App.  [15:00] Mitochondria 101: The Mini Suns That Live Inside of Us  The mitochondria are our suns within us.  They make energy.  The mitochondria take information from the sun, food, electrons, and oxygen. Then, they pack up this molecule called ATP, which gives direction to our DNA. [19:30] There Are Over 600,000 Mitochondria Fertilization In One Cell The brain, the eyes, the heart, and the ovaries have the highest concentration of mitochondria.  In fact, an egg has 600,000 mitochondria fertilization in one cell.  You have to kick start a consciousness in one cell. The night before ovulation, the egg takes 20 billion zinc atoms into it. The egg has more mitochondria than the brain; it's magic.   [21:20] Fertility Rates Are Declining: Here's What You Can Do Women are getting pregnant older. Fertility is continuing to decline.  We are poisoning our eggs and our sperm over generations. There are fewer pregnancies and fewer healthy children.  Fertility rates will plummet because of our toxic environment and poor nutrition.  You have to find ways to lower insulin.  Practice fasting so you can get rid of toxins.  [27:50] The Real Reason Autism Rates Are Increasing In Our Population  Evolutionarily speaking, the genetics of autism predates the split from humans to primates.  Prior to the DSM removing Asperger's, autistic people would have been diagnosed with Asperger's. People with Asperger's would have been the people who are putting cities together, building things, and staying by the fire.  People with autism now have neuroinflammation. There are too many pesticides and heavy metals.  Plus, there are too many providers who don't understand the difference between neuroinflammation and autism.  [32:40] Why Mental Health Is Decreasing and How You Can Lower Inflammation In The Brain  Water follows carbs. If you have too much sugar and alcohol, you better spend some time fasting to get rid of the inflammation. If your rings are too tight, your brain is inflamed.  When you're inflamed, you are puffing up your nerves like you're puffing up your fingers.  If you're not giving yourself the right building blocks, your brain will stay inflamed. So, you need to lower your inflammation through nutrition and fasting.  [46:40] You Need To Get More Vitamin D From Sunlight  You want your vitamin D between 65 and 85 by the end of the summer.  If your vitamin D is 12, you will need a supplement. Once you open your brain and realize you are supposed to be naked in the sun, then you will use that in a 365-day cycle to heal yourself. Pills won't fix your problems.  The solar light will fix your problems, and so will a ketogenic lifestyle.  AND MUCH MORE! Resources from this episode:  Check out Dr. Hunt's Website: https://www.courtneyhuntmd.com/ Genetic Protocol: https://geneticprotocol.com/ Follow Dr. Hunt Instagram: https://www.instagram.com/courtneyhuntmd/ YouTube: https://www.youtube.com/channel/UCqLXOBreGFib_GtSfTD9tPw D Minder App: https://apps.apple.com/us/app/d-minder-pro/id547102495 Your Spark Is Light: https://www.courtneyhuntmd.com/your-spark-is-light Your Spark Is Light on Amazon: https://www.amazon.com/Your-Spark-Light-Mechanics-Creation/dp/B098CNYZK9/benazadi-20 Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ JOIN MY 90 DAY HEAVY METALS DETOX PROGRAM (11 SPOTS LEFT): HTTP://WWW.KETOKAMPDETOX.COM  Order Keto Flex: http://www.ketoflexbook.com -------------------------------------------------------- / / E P I S O D E   S P ON S O R S  Biotiquest Sugar Shift product. Regulate glucose, reduce cravings, achieve deeper ketosis, and remove glyphaste.  https://biotiquest.com/products/sugar-shift Use the coupon code KAMP10 for 10% off their products.  Get Bioptimizers Magnesium Breakthrough for the best night of sleep, ever! Nurture your mind and body with this all-natural, full-spectrum magnesium supplement. Visit www.magbreakthrough.com/ketokamp and use code ketokamp10 for 10% off.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Y'all remember that song 'Under the Sea' by that crab in Disney's Little Mermaid? This is like that, except horrifying. Featuring: The cutest date known to humankind, Tess the Druid being pro-littering, a spliced gangster, everyone conspiring to force Alex the DM to murder an NPC Follow us! Jess the Mess: @JessLTwrites Anthony LaFauci: @AnthonyLaFauci Dianna Lee: @diannasaurusr3x Garion Neuse: youtube.com/@kanashi6804 Alexander James: @drunkscribe @Critically Stupid #podcast #dnd #ttrpg #dungeonsanddragons #dnd5e This episode is brought to you by the DOPE-ASS dice sets at librisarcana.com. Check them out with our exclusive discount code STUPID20 for 20% off site-wide.

Fellow podcaster and comedian Francis Foster of the Triggernometry podcast joins Dan to talk about his struggles with alcohol addiction and how he used his ambition to combat it. Dan and Francis also delve deep into the world of comedy and podcasting including being featured on the Joe Rogan podcast, cancel culture and how comedy has evolved in their lifetime and not always for the better. An episode that really evolves through the hour and features segments on mindset, tips on dealing with addiction and ADHD as well as Dan talking about the time he passed to the other side!   KEY TAKEAWAYS  Many comedians out there worry about older jokes from their past coming to light and running the risk of them being ‘cancelled'. No comedian is immune to the current cancel culture in comedy. Francis was featured on the Joe Rogan podcast recently, Francis found Joe very inspiring and reveals that who you hear and see with Joe is the real him, he is authentic and giving to the podcasting space. Comedians can struggle in the UK, many are too focused on being politically correct. The U.S has a very different comedic landscape, they seem to allow more free speech in comedy. Francis believe being mixed race allows him to question British culture more, it gives him a unique perspective. Evolutionarily speaking, it's important we take notice of and remember threats. This is why negative press, comments and trolling online can be so hard to ignore. It's easy to be misrepresented, you need to be clear with what you say so that things you say can't be misinterpreted or taken out of context. Both Francis and Dan have ADHD, there are a lot of mental health struggles that come alongside this diagnosis but they both find that there are things they can do to help themselves, such as regular exercise and reducing mobile phone use. Francis was the type of drinker that didn't ‘need' a pint but as soon as he had one he would struggle to stop and the aftermath the next day was incredibly difficult to deal with mentally. Francis realised that to achieve the things he wanted to and be successful he could no longer have alcohol in his life. If you really want to do something, you will do it. Francis believes if your motivation is powerful then you can and will give up your addiction and this is why he was able to become sober for 12 years. Lad culture is detrimental for men in the UK and feeds into the widespread alcohol and drug problems found in our society. What happens, happens to you but how you choose to respond to it gives you control. CBT is a form of therapy that changes how you view situations and is something Francis uses, it's also the only form of therapy proven to work in this way.   BEST MOMENTS  “I just use stand up as my drug” “You're judging a 1992 joke by 2022 standards and that's not fair” “There is no difference between Joe Rogan the podcaster and Joe Rogan the host” “The funniest comedy is when you say I can't believe they just said that” “Comedy is the blues for people who can't sing” “I couldn't see any light, I couldn't see any positive. I realised if I wanted to make something of myself, if I wanted to achieve I couldn't have booze in my life” “The amazing things you have achieved in life have come from ambition, from wanting to better yourself” “I wanted to have a career in comedy and I wanted to be great in comedy. I just knew if I drank that would never be an option” “I think you probably died for a second” VALUABLE RESOURCES https://francisfoster.co.uk/ https://podcasts.apple.com/gb/podcast/triggernometry/id1375568988   CONTACT METHOD Instagram Facebook Twitter   ABOUT THE GUEST  Francis Foster Podcast co-host to the Triggernometry podcast and stand-up comedian https://francisfoster.co.uk/ https://podcasts.apple.com/gb/podcast/triggernometry/id1375568988 https://instagram.com/francisjfoster?igshid=YmMyMTA2M2Y= https://instagram.com/triggerpod?igshid=YmMyMTA2M2Y= "My name is Francis Foster and I am a stand up comedian and co host of the Triggernometry Youtube show. We are about to hit 500K subscribers on Youtube and I appeared on the Joe Rogan Experience last year with my co host Konstantin Kisin. I am mixed race and my mother is from Venezuela. I saw Venezuela become a communist country in 1999 and slowly collapse until we are now one of the poorest nations in the world. 96% of Venezuelans live in poverty and it is ruled by a brutal authoritarian dictator. My father comes from a working class background from the North West. This has meant that I have always felt like an outsider to some degree wherever I've lived. I also have ADHD which has meant that I have struggled to function and have had issues with alcohol and weed in particular. I self medicated for a number of years as I struggled to get my career off the ground before quitting alcohol completely 12 years ago. My diagnosis and therapy have made it easier for me to function and become successful helping to build one of the UK's biggest and fastest growing UK podcasts." ABOUT THE HOST Daniel O'Reilly Daniel O'Reilly is one of the UK's Largest Influencers, a comedian, actor, musician, viral video star and social influencer. With a portfolio of businesses Daniel enjoys a busy lifestyle mixed with business and pleasure. Daniel is a father to two beautiful girls and enjoys spending quality time with them and his wife Shelley. With 2022 being a busy year, Daniel sold out his O2 stand-up show, released his British movie 'The Last Heist'  and is currently preparing for the upcoming release of his other film 'Miss The Kiss'. Daniel is a creative through and through, with a passion to strive in everything he does. Daniel is looking forward to the release of his podcast 'Menace 2 Sobriety' in 2023, his long-term position on GB News, Headliners, and the growing slate of films in the works with his production company, HYPRR.    PODCAST DESCRIPTION   Daniel O'Reilly's newest venture sees the creation of his Menace 2 Sobriety podcast, a series of relaxed and open conversations with different guests and varied experiences.    After recently being diagnosed with severe ADHD and beginning his sobriety again, Daniel also set up a page on Facebook and Instagram called 'Men And Their Emotions' (M.A.T.E) an accessible, open and supportive group for MEN to post their feelings, thoughts and current life issues. Upon seeing the responses from men around the world to some of the posts on the group he was blown away and continues to be touched by the kindness and support offered by strangers. This all led to Daniel wanting to start up his own podcast and invite guests to join him in opening up about past experiences and talk about all things mental health, family & sobriety.    The podcast will see Daniel and his interesting guests' sharing their personal stories and learning experiences that they hope will help other people; whether it encourages one person to ask for help, talk to family about their struggles with getting sober/clean, or realise that they aren't alone. The Menace 2 Sobriety podcast has been created by Daniel to help people fight their own gremlins.Sobriety Podcast #wedorecover # recoveroutloud #addicitonrecovery #addiction #recoverytok #sobriety #sober #sobertiktok #sobertok #soberlife #sobercurious #soberliving: https://www.instagram.com/dappersinstagram/See omnystudio.com/listener for privacy information.

This week, Aaron and Leyla optimize their SEO with the 1993 Super Mario Brothers movie! Join us for a discussion of the cutthroat NYC plumbing industry, the value of consistent (if batshit!) internal logic, and a lukewarm defense of John Leguizamo's weird take on the new Super Mario Bros movie. Pokemon Apokelypse: Live Action Trailer HD https://www.youtube.com/watch?v=sDX1m0Y2Vkg Palworld | Gameplay Moments Trailer 2022.5 https://www.youtube.com/watch?v=-EJckERWcO0 The Messy True Story Behind 1993's 'Super Mario Bros.' Movie https://collider.com/super-mario-bros-movie-1993-history-explained/ --- Twitter: @MortifiedPod Hosts' Twitters: @aaronsxl / @leylses Hotline: ‪(775) 573-8882 Sign up for our monthly newsletter, which has additional takes and our personal recs. Our theme song is "Obsolete" by Keshco, from the album "Filmmaker's Reference Kit Volume 2." Our other projects: Aaron's TTRPGs Aaron's TTRPG Reviews aavoigt.com The Bible Boys Astral Heart

Hvordan vil ChatGPT påvirke helsevesenet? Verden er på god vei til å nå målet med å bekjempe aids som global helsetrussel innen 2030. Peanøttallergi blir stadig mer vanlig – bør kostholdsrådene oppdateres? Hva er de akutte helseeffektene av å drikke kaffe? Og hva er den beste behandlingen mot korsryggssmerter? Ny svensk forskning viser at mannlige fotballspillere på elitenivå har mer enn 50 % høyere risiko enn den generelle befolkningen for å utvikle nevrodegenerative lidelser. Mødredødeligheten i USA fortsetter å stige. Bør vitenskapelige tidsskrifter støtte politiske kandidater? Hvorfor føler vi empati? Og hva døde Beethoven av? Hør om dette og mer i ukens episode av Redaktørens hjørne med Are Brean.Tilbakemeldinger kan sendes til stetoskopet@tidsskriftet.no.  Stetoskopet produseres av Synne Muggerud Sørensen, Sigurd Ziegler, Are Brean og Julie Didriksen ved Tidsskrift for Den norske legeforening. Ansvarlig redaktør er Are Brean.  Jingle og lydteknikk: Håkon Braaten / Moderne media  Coverillustrasjon: Stephen Lee Artikler nevnt:Will ChatGPT transform healthcare? Artificial Intelligence and Machine Learning in Clinical Medicine, 2023 Artificial Intelligence in Medicine Benefits, Limits, and Risks of GPT-4 as an AI Chatbot for Medicine World on Path to Eliminate AIDS as a Global Threat by 2030Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort: A Prospective Observational Cohort Study Contemporary Natural History of Coronary Artery Disease Babies should be given peanut products between 4 and 6 months to reduce allergy, say researchers Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy: A Systematic Review and Meta-analysis Acute Effects of Coffee Consumption on Health among Ambulatory Adults Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysisMale footballers are 50% more likely to develop neurodegenerative disease, finds Swedish study Neurodegenerative disease among male elite football (soccer) players in Sweden: a cohort study US Maternal Mortality Continues to Worsen Should Nature endorse political candidates? Yes — when the occasion demands it Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish In Science Journals Beethoven's cause of death revealed from locks of hair

https://psychiatry.dev/wp-content/uploads/speaker/post-12337.mp3?cb=1679327338.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Evolutionarily conserved regulators of tau identify targets for new therapies – PubMed Jiyoen Kim et al. Neuron. 2023. Tauopathies are neurodegenerative diseasesFull EntryEvolutionarily conserved regulators of tau identify targets for new therapies – PubMed

This week on the podcast, Bre is here to tell you why putting yourself in a box is the enemy of growth.Evolutionarily, our existence depended on us fitting in and finding a tribe so we weren't outcast and left to fend for ourselves. As a result of this, we will instinctively try to fit inside whatever box we feel will aid in our being included. We're social creatures - we need to belong.That being said, we need to be aware and conscious of the labels we give ourselves and the impact it can have on our growth.Listen to the full ep to hear Bre discuss:

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.10.528061v1?rss=1 Authors: Willbrand, E. H., Jackson, S., Chen, S., Hathaway, C. B., Voorhies, W. I., Bunge, S. A., Weiner, K. S. Abstract: Identifying structural-functional correspondences is a major goal among biologists. In neurobiology, recent findings identify relationships between performance on cognitive tasks and the presence or absence of small, shallow indentations, or sulci, of the human brain. Here, we tested if the presence or absence of one such sulcus, the paraintermediate frontal sulcus (pimfs-v) in lateral prefrontal cortex, was related to relational reasoning in young adults from the Human Connectome Project (ages 22-36). After manually identifying 2,877 sulci across 144 hemispheres, our results indicate that the presence of the pimfs-v in the left hemisphere was associated with a 21-34% higher performance on a relational reasoning task. These findings have direct developmental and evolutionary relevance as recent work shows that the presence or absence of the pimfs-v is also related to reasoning performance in a pediatric cohort, and that the pimfs-v is exceedingly rare in chimpanzees. Thus, the pimfs-v is a novel developmental, cognitive, and evolutionarily relevant feature that should be considered in future studies examining how the complex relationships among multiscale anatomical and functional features of the brain give rise to abstract thought. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.10.523378v1?rss=1 Authors: Tsujioka, S., Sumino, A., Nagasawa, Y., Sumikama, T., Flechsig, H., Puppulin, L., Tomita, T., Baba, Y., Kakuta, T., Ogoshi, T., Umeda, K., Kodera, N., Murakoshi, H., Shibata, M. Abstract: Ca2+/calmodulin-dependent protein kinase II (CaMKII) has long been central in synaptic plasticity research. CaMKII is a dodecameric serine/threonine kinase that has been essentially conserved across metazoans for over a million years. While the mechanisms of CaMKII activation are well studied, its "behavior" at the molecular level has remained unobserved. Here, high-speed atomic force microscopy was used to visualize the activity-dependent structural dynamics of rat/hydra/C. elegans CaMKII in various states at nanometer resolution. Among the species, rat CaMKII underwent internal kinase domain aggregation in an activity-dependent manner and showed a higher tolerance to dephosphorylation by phosphatase. Our findings suggest that mammalian CaMKII has evolutionarily acquired a new structural form and a tolerance to phosphatase to maintain robust CaMKII activity for proper neuronal function. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This episode contains: Steven and Devon record on a glorious Sunday afternoon. Where's Ben? It's fun to have Nicole Lawless on the show (ep421) as an actual science person. Devon woke up in a good mood, until he watched the Star Trek: Picard trailer. That Star Trek: Picard trailer was TOO DARK. Brighten it up! Devon continues to work on removing the tree stump. With fire. When Devon removed the stump, did he shout "STUMPFEST"? Steven and Devon drool over the new Lego Razorcrest. Lego just bumped up all their prices due to inflation. Crazy. Steven finally gets a day off from single dad duty after Martine's recovery. Ok ok ok, where's Ben? Lego: so much money for plastic in different orientations.  Evolutionarily speaking: Dead fish breathes new life into the evolutionary origin of fins and limbs. Evolution is AWESOME. Devon's 4yo. asked "when were chickens invented?" Devon talks evolution. Previously, our galeaspid fossils only had heads. Now we have a whole fossil. Primitive creatures on earth either had fins or limbs. Not both. If it wasn't for one measely asteroid, the dinosaurs would still be here. Is there a dinosaur planet out there? Is that where Ben is? https://www.sciencedaily.com/releases/2022/09/220928113007.htm Stressed friend: Dogs can smell when we're stressed, study suggests. A psychological stress response alters odor profile in our breath or sweat. Dogs can detect an odor change in VOCs produced by humans in response to stress. Want to test stress among study participants? Give them Math tasks! https://www.sciencedaily.com/releases/2022/09/220929133419.htm Common gene variant linked to COVID mortality: Presence of the APOE gene can predict cancer, dementia, and COVID severity. https://www.sciencedaily.com/releases/2022/09/220921093000.htm Science Fiction: We have a picture of the hosts in Lower Decks style. Join our Patreon to see it! You want a whole episode of Lower Decks about Peanut Hamper? Be careful what you wish for. And they didn't really do any development on the character of Peanut Hamper. The bird people made Lower Decks feel like Rick & Morty. More Jeffrey Combs in Lower Decks this last week. AGIMUS is back, baby! But not Ben, I guess. Worf is a super serious Klingon, because he wasn't raised as one. Picard season 3 trailer came out, and everybody is SOOOO OLLLLLD. So... Worf is a pacifist now? Cool. We're down for it. Worf started as a cliche, but thanks to DS9 he's a well-rounded character. Big spiky ship now wants to blow us up, like the last few Star Trek films. Round ships vs. spiky ships: It's a simple rock-paper-scissors situation. How does 7 of 9 become captain of a Starfleet ship, given the first two seasons of Picard? Devon tears apart the ships of Picard season 3. Devon will not sell his Eaglemoss ships, even though it's out of business. Devon likes Andor! At least the first two episodes! The internet breaks! Devon review's Dennis E. Taylor's new book: Roadkill. Light read and fun. The A.I. in Roadkill is kinda like if the character Frasier from the show Frasier wanted to kill humans. Steven reviews The Long Way to a Small, Angry Planet by Becky Chambers:

Modern Wisdom Podcast Notes Ways to safely add friction to your life & raise stress threshold to enhance your ability to stay calm under pressure: cold shower, ice bath, cyclic hyperventilation – stress grows youGrief is a motivated state of being highly alert but very sad, where we try to bridge the space and time of a loved one but it's impossible since that person is gone – the brain has to confront the reality that someone is goneThe ability to feel the feelings helps you move through a breakup: women reportedly experience higher levels of emotional pain during a breakup but recover more fully over time; men rarely fully recoverIf we expose regularly expose ourselves to things that trigger high levels of dopamine release, we will actually lower our baseline levels of dopamine over timeTo maintain high levels of motivation, try intermittent rewards: celebrate successes every other time, every tenth time, etc. to blunt dopamine response, prevent crashes, and keep you on the path to bigger goalsLessons from Lex Fridman: There are a lot of energy pits but success is really about not allowing energy to dissipate into negative trails (e.g., fighting people online, cynics, etc.)Evolutionarily, mating is a test as to whether two people can coordinate autonomic nervous systemsActual + perceived = reality: any event causes a real physiological response, but that response is entangled with our expectation of what the response should beTap into whatever eating system works for you – but one thing is true, consistency helps anchor your sleep scheduleLight, exercise, and temperature (hot and cold) are potent stimuli for creating hormonal and neuromodulator effects – it works the first time and every timeRead the full notes @ podcastnotes.orgDr Andrew Huberman is a neuroscientist, Associate Professor at the Stanford University School of Medicine and a podcaster. The mind and the body are intimately linked. Trying to improve your mental outcomes without thinking of your physical inputs is a losing battle, but the question of which inputs to use, and when is a huge challenge. Thankfully, Dr Huberman is one of the best communicators of high performance advice on the planet and has a lot of answers. Expect to learn the neuroscience of getting over your ex, how David Goggins trained himself to lean into fear, whether dopamine detoxing really works, the most important things to avoid doing during your morning routine, just how worried we should be about men's testosterone levels dropping, what everyone can learn about endurance from Lex Fridman, why Andrew doesn't show his tattoos and much more... Sponsors: Join the Modern Wisdom Community to connect with me & other listeners - https://modernwisdom.locals.com/ Get 5 Free Travel Packs, Free Liquid Vitamin D and Free Shipping from Athletic Greens at https://athleticgreens.com/modernwisdom (discount automatically applied) Get 20% discount on Impossible's sleep powder at https://impossible.co/modernwisdom (use code: MW20) Get 10% discount on your first month from BetterHelp at https://betterhelp.com/modernwisdom (discount automatically applied) Extra Stuff: Check out the Huberman Lab Podcast - https://hubermanlab.com/ Follow Dr Huberman on Instagram - https://www.instagram.com/hubermanlab/  Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ 

Annnnnnd, they're back after months...Summer is busy for Moms as you know! This episode was recorded as summer started and the Johnny Depp and Amber Heard case wrapped, lol. On this episode the ladies discuss cleaning - or lack there of - with kids, evolutionarily attractiveness, "beauty back in our day," Lydia's WTF stage in childhood, and Johnny Depp wins.

GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/fructose 2:05 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome! 2:15 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon 3:00 - AVALONX SERRAPEPTASE: Get Melanie's Serrapeptase Supplement: A Proteolytic Enzyme Which May Help Clear Sinuses And Brain Fog, Reduce Allergies, Support A Healthy Inflammatory State, Enhance Wound Healing, Break Down Fatty Deposits And Amyloid Plaque, Supercharge Your Fast, And More!  AvalonX Supplements Are Free Of Toxic Fillers And Common Allergens (Including Wheat, Rice, Gluten, Dairy, Shellfish, Nuts, Soy, Eggs, And Yeast), Tested To Be Free Of Heavy Metals And Mold, And Triple Tested For Purity And Potency. Order At AvalonX.us, And Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At melanieavalon.com/avalonx 5:10 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More!  6:00 - BEAUTYCOUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At beautycounter.com/melanieavalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beautycounter Email List At melanieavalon.com/cleanbeauty! Find Your Perfect Beautycounter Products With Melanie's Quiz: melanieavalon.com/beautycounterquiz 10:50 - Beginning Of Fructose Research 14:30 - How Sugar Can Cause Weigh Gain Independently Of Caloric Intake 17:30 - Leptin Resistance 19:20 - BEAUTY AND THE BROTH: Support Your Health With Delicious USDA Organic Beauty & The Broth Bone Broth! It's Shelf Stable With No Preservatives, And No Salt Added. Choose Grass Fed, Grass Finished Beef, Or Free Range, Antibiotic And Hormone-Free Chicken, Or Their NEW Organic Vegan Mushroom Broth Concentrate Shipped Straight To Your Door! The Concentrated Packets Are 8x Stronger Than Any Cup Of Broth: Simply Reconstitute With 8 Ounces Of Hot Water. They're Convenient To Take Anywhere On The Go, Especially Travel! Go To Melanieavalon.Com/Broth To Get 15% Off Any Order With The Code MelanieAvalon! 23:10 - Defining Glucose, Sucrose, And Fructose 26:55 - "Tasteless" Mice 28:00 - Craving Sugar  31:20 - 5 Great Tastes 33:00 - Artificial Sweeteners 34:00 - Blocking The Fructokinase In The Liver 36:00 - How Fructose Tricks The Body 42:10 - How Fructose Uses Glucose To Create Fat 50:00 - Polyol Pathway 51:40 - Stress & Dehydration 53:50 - Salt 57:00 - NUTRISENSE: Get Your Own Personal Continuous Glucose Monitor (CGM) To See How Your Blood Sugar Responds 24/7 To Your Food, Fasting, And Exercise! The Nutrisense CGM Program Helps You Interpret The Data And Take Charge Of Your Metabolic Health! Learn More About Nutrisense In Melanie's Interview With Founder Kara Collier At melanieavalon.com/nutrisense. Get $40 Off A CGM At nutrisense.io/melanie With The Code MelanieAvalon 1:00:30 - How Hibernation Mimics Metabolic Syndrome 1:04:30 - Evolutionarily, Where Did This Start? 1:07:45 - The Natural Fasting Cycle 1:08:30 - The Role Of Fructose In The Cells, AMPK, And AMPD 1:16:00 - What Happens When You Combine Starvation With The AMPK Pathway? 1:21:00 - Starvation Mode 1:24:30 - What About Whole Fruit? The Role Of Vitamin C

Do you need to be Vegan to be a true Yogi? And why do yoga teacher trainings often implement a strictly vegan or vegetarian diet? In this episode, we discuss veganism and how it ties into the yogic principle of Ahimsa (non-violence). We hear both Byron and Michael's own personal views and backgrounds. And the ethical or moral aspect and understanding of Ahimsa and how that relates to a vegan or non-vegan diet. Plus they discuss the evolutionary and ancestral aspect of if humans are adapted to being meat eaters or vegans. If you want to understand whether it's necessary to be vegan to be a yogi or not, then listen to the full episode… (01:24) Veganism in yoga teacher trainings (03:59) Ahimsa and how it relates to veganism (07:10) Byron grew up on a ranch with hundreds of cows (09:04) Are you the broccoli? (11:47) Evolutionarily and ancestrally humans are both carnivorous and vegetarian/vegan. (13:54) Are our teeth designed for a plant-based diet, a meat diet, or do we even need teeth at all? (15:27) The ethics of over-production of cattle and crops (18:08) Getting sidetracked by AI and robot nightmares (20:37) Plot Twist: We went full circle back to the ethics of non-harming --- Send in a voice message: https://anchor.fm/goingproyoga/message

Today, I am blessed to have here with me Dr. Courtney Hunt. She attended the University of California at Berkeley for her undergraduate studies and continued her education at Loyola School of Medicine in Chicago, Illinois.  She completed her Obstetrics and Gynecology residency at UCLA. Dr. Hunt practiced obstetrics and gynecology for 15 years before stopping obstetrics to pursue her interest in quantum biology and nutrigenetics or the interaction between our environment and our DNA. Dr. Hunt began investigating the intersection between the physics of light, mitochondria, and DNA to determine the best practices and methods to keep us healthy.  She has successfully treated patients with complex and chronic issues, she has developed integrative protocols to address a variety of illnesses that include thyroid and hormone balancing, nutritional genetics, and mitochondrial function assessment. She also believes in the optimization of human potential for the individual, our families, our communities, and society. The mission is love, and when we all learn to heal inflammation one by one that is when we come to work together for the good of humanity. In this episode, Dr. Hunt opens the show by explaining why healing your body through sunlight and nutrition should be more mainstream. Then, Dr. Hunt dives into how the energy from the sun is everything, and it feeds all forms of life on this planet. If you aren't getting your daily dose of sunlight, your body won't naturally heal itself. Plus, Dr. Hunt reveals the real reason autism rates are increasing globally. Tune in as we chat about improving vitamin D levels, why we have a mental health crisis, and the importance of lowering inflammation in the brain.  Order Keto Flex: http://www.ketoflexbook.com Free Keto Webinar: www.ketosismasterclass.com  -------------------------------------------------------- / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use KETOKAMP15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  [00:50] Fixing Problems With Nutrition Should Become More Mainstream  Dr. Hunt had two children back to back. At one point, Dr. Hunt could barely read; she realized that she was losing her cognition.  After doing research, Dr. Hunt realized a massive problem with her patients and their nutrition. To solve problems, you have to look at the symptoms and figure out what foods or supplements will help build better cells.  [07:10] Energy Is Everything: How The Sun Can Help Heal Your Body The sun in the sky is in thermodynamic equilibrium with Earth. The light in the sun gives us all the energy to grow plants and for the plants to perform photosynthesis.  Those plants are cleaning our environment and making oxygen for us to breathe, and we are burning the oxygen as fuel.  When you understand electromagnetic radiation, it is frequencies of energy. The energy from the sun is feeding animals, plants, and humans.  All information comes from sunlight either, directly or indirectly.  [10:20] Should You Go Outside and Get More Sunshine Today?  You should be outside no matter where you live. Also, be cognizant of your skin type. Dr. Hunt recommends getting the D Minder App: https://apps.apple.com/us/app/d-minder-pro/id547102495 You need just the right amount of sunlight.  Don't scroll on Instagram all day; instead, play with the D Minder App.  [15:00] Mitochondria 101: The Mini Suns That Live Inside of Us  The mitochondria are our suns within us.  They make energy.  The mitochondria take information from the sun, food, electrons, and oxygen. Then, they pack up this molecule called ATP, which gives direction to our DNA. [19:30] There Are Over 600,000 Mitochondria Fertilization In One Cell The brain, the eyes, the heart, and the ovaries have the highest concentration of mitochondria.  In fact, an egg has 600,000 mitochondria fertilization in one cell.  You have to kick start a consciousness in one cell. The night before ovulation, the egg takes 20 billion zinc atoms into it. The egg has more mitochondria than the brain; it's magic.   [21:20] Fertility Rates Are Declining: Here's What You Can Do Women are getting pregnant older. Fertility is continuing to decline.  We are poisoning our eggs and our sperm over generations. There are fewer pregnancies and fewer healthy children.  Fertility rates will plummet because of our toxic environment and poor nutrition.  You have to find ways to lower insulin.  Practice fasting so you can get rid of toxins.  [27:50] The Real Reason Autism Rates Are Increasing In Our Population  Evolutionarily speaking, the genetics of autism predates the split from humans to primates.  Prior to the DSM removing Asperger's, autistic people would have been diagnosed with Asperger's. People with Asperger's would have been the people who are putting cities together, building things, and staying by the fire.  People with autism now have neuroinflammation. There are too many pesticides and heavy metals.  Plus, there are too many providers who don't understand the difference between neuroinflammation and autism.  [32:40] Why Mental Health Is Decreasing and How You Can Lower Inflammation In The Brain  Water follows carbs. If you have too much sugar and alcohol, you better spend some time fasting to get rid of the inflammation. If your rings are too tight, your brain is inflamed.  When you're inflamed, you are puffing up your nerves like you're puffing up your fingers.  If you're not giving yourself the right building blocks, your brain will stay inflamed. So, you need to lower your inflammation through nutrition and fasting.  [46:40] You Need To Get More Vitamin D From Sunlight  You want your vitamin D between 65 and 85 by the end of the summer.  If your vitamin D is 12, you will need a supplement. Once you open your brain and realize you are supposed to be naked in the sun, then you will use that in a 365-day cycle to heal yourself. Pills won't fix your problems.  The solar light will fix your problems, and so will a ketogenic lifestyle.  AND MUCH MORE! Resources from this episode:  Check out Dr. Hunt's Website: https://www.courtneyhuntmd.com/ Genetic Protocol: https://geneticprotocol.com/ Follow Dr. Hunt Instagram: https://www.instagram.com/courtneyhuntmd/ YouTube: https://www.youtube.com/channel/UCqLXOBreGFib_GtSfTD9tPw D Minder App: https://apps.apple.com/us/app/d-minder-pro/id547102495 Your Spark Is Light: https://www.courtneyhuntmd.com/your-spark-is-light Your Spark Is Light on Amazon: https://www.amazon.com/Your-Spark-Light-Mechanics-Creation/dp/B098CNYZK9/benazadi-20 Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Order Keto Flex: http://www.ketoflexbook.com Free Keto Webinar: www.ketosismasterclass.com  -------------------------------------------------------- / / E P I S O D E   S P ON S O R S  PureForm Omega Plant Based Oils (Best Alternative to Fish Oil): http://www.purelifescience.com Use ben4 for $4.00 off. Paleo Valley beef sticks, apple cider vinegar complex, organ meat complex & more. Use the coupon code KETOKAMP15 over at https://paleovalley.com/ to receive 15% off your entire order. Upgraded Formulas Hair Mineral Deficiency Analysis & Supplements: http://www.upgradedformulas.com Use KETOKAMP15 at checkout for 15% off your order.  Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list.  *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. Opinions of guests are their own, and this podcast does not accept responsibility of statements made by guests. This podcast does not make any representations or warranties about guests qualifications or credibility. Individuals on this podcast may have a direct or non-direct interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

Nick Bare is an American YouTuber, Author, and entrepreneur. He is the CEO of Bare Performance Nutrition, founder of Embrace The Suck Training Program, and host of The Bare Performance podcast.     00:10:01 Podcast with Nick Bare begins 00:12:19 Hunting and consuming animal blood 00:19:20 Nutrition education and disease management versus biochemistry 00:20:53 Bow hunting and open fire cooking 00:23:53 The history and dangers of seed oils  00:34:53 Linoleic acids versus stearic acids, and saturated fats versus unsaturated fats 00:51:43 Where people are getting most of their linoleic acid, and thoughts on avocado/olive oil 00:57:53 Three main things to eliminate from your diet for improved health 1:02:53 Evolutionarily consistent foods and the sugar industry 1:06:38 Fruit as a primary carb source and Paul's health journey  1:26:53 Obesity, appetite and weight loss 1:32:23 What is insulin resistance/metabolic dysfunction? 1:42:30 How do we recover from metabolic dysfunction and decrease linoleic acid intake? 1:48:53 Linoleic acid in formula versus breast milk 1:50:53 Avoiding seed oils while eating out     Where to find Nick Bare: Podcast: The Bare Performance Podcast Instagram: @thebareperformancepodcast Twitter: @BarePerformPod Website: www.bpnsupps.com

Article: Plant PIEZO homologs modulate vacuole morphology during tip growth Journal: Science Year: 2021 Guest: Ivan Radin Host: Arif Ashraf Molecular Plant Editorial highlight: Evolutionarily conserved mechanosensor PIEZO in land plants Abstract In animals, PIEZOs are plasma membrane–localized cation channels involved in diverse mechanosensory processes. We investigated PIEZO function in tip-growing cells in the moss Physcomitrium patens and the flowering plant Arabidopsis thaliana. PpPIEZO1 and PpPIEZO2 redundantly contribute to the normal growth, size, and cytoplasmic calcium oscillations of caulonemal cells. Both PpPIEZO1 and PpPIEZO2 localized to vacuolar membranes. Loss-of-function, gain-of-function, and overexpression mutants revealed that moss PIEZO homologs promote increased complexity of vacuolar membranes through tubulation, internalization, and/or fission. Arabidopsis PIEZO1 also localized to the tonoplast and is required for vacuole tubulation in the tips of pollen tubes. We propose that in plant cells the tonoplast has more freedom of movement than the plasma membrane, making it a more effective location for mechanosensory proteins. --- Send in a voice message: https://anchor.fm/no-time-to-read-podcast/message

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is Three Worlds Collide, Part 3: The Super Happy People (3/8), published by Eliezer Yudkowsky. ...The Lady Sensory said, in an unsteady voice, "My lords, a third ship has jumped into this system. Not Babyeater, not human." The holo showed a triangle marked with three glowing dots, the human ship and the Babyeater ship and the newcomers. Then the holo zoomed in, to show - - the most grotesque spaceship that Akon had ever seen, like a blob festooned with tentacles festooned with acne festooned with small hairs. Slowly, the tentacles of the ship waved, as if in a gentle breeze; and the acne on the tentacles pulsated, as if preparing to burst. It was a fractal of ugliness, disgusting at every level of self-similarity. "Do the aliens have deflectors up?" said Akon. "My lord," said Lady Sensory, "they don't have any shields raised. The nova ashes' radiation doesn't seem to bother them. Whatever material their ship is made from, it's just taking the beating." A silence fell around the table. "All right," said the Lord Programmer, "that's impressive." The Lady Sensory jerked, like someone had just slapped her. "We - we just got a signal from them in human-standard format, content encoding marked as Modern English text, followed by a holo -" "What?" said Akon. "We haven't transmitted anything to them, how could they possibly -" "Um," said the Ship's Engineer. "What if these aliens really do have, um, 'big angelic powers'?" "No," said the Ship's Confessor. His hood tilted slightly, as if in wry humor. "It is only history repeating itself." "History repeating itself?" said the Master of Fandom. "You mean that the ship is from an alternate Everett branch of Earth, or that they somehow independently developed ship-to-ship communication protocols exactly similar to our -" "No, you dolt," said the Lord Programmer, "he means that the Babyeaters sent the new aliens a massive data dump, just like they sent us. Only this time, the Babyeater data dump included all the data that we sent the Babyeaters. Then the new aliens ran an automatic translation program, like the one we used." "You gave it away," said the Confessor. There was a slight laugh in his voice. "You should have let them figure it out on their own. One so rarely encounters the apparently supernatural, these days." Akon shook his head, "Confessor, we don't have time for - never mind. Sensory, show the text message." The Lady Sensory twitched a finger and - HOORAY! WE ARE SO GLAD TO MEET YOU! THIS IS THE SHIP "PLAY GAMES FOR LOTS OF FUN" (OPERATED BY CHARGED PARTICLE FINANCIAL FIRMS) WE LOVE YOU AND WE WANT YOU TO BE SUPER HAPPY. WOULD YOU LIKE TO HAVE SEX? Slowly, elaborately, Akon's head dropped to the table with a dull thud. "Why couldn't we have been alone in the universe?" "No, wait," said the Xenopsychologist, "this makes sense." The Master of Fandom nodded. "Seems quite straightforward." "Do enlighten," came a muffled tone from where Akon's head rested on the table. The Xenopsychologist shrugged. "Evolutionarily speaking, reproduction is probably the single best guess for an activity that an evolved intelligence would find pleasurable. When you look at it from that perspective, my lords, my lady, their message makes perfect sense - it's a universal friendly greeting, like the Pioneer engraving." Akon didn't raise his head. "I wonder what these aliens do," he said through his shielding arms, "molest kittens?" "My lord..." said the Ship's Confessor. Gentle the tone, but the meaning was very clear. Akon sighed and straightened up. "You said their message included a holo, right? Let's see it." The main screen turned on. There was a moment of silence, and then a strange liquid sound as, in unison, everyone around the table gasped in shock, even the Ship's Confessor. For a time after that, no one spoke. They were just... watchin...

Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is Three Worlds Collide, Part 3: The Super Happy People (3/8), published by Eliezer Yudkowsky. ...The Lady Sensory said, in an unsteady voice, "My lords, a third ship has jumped into this system. Not Babyeater, not human." The holo showed a triangle marked with three glowing dots, the human ship and the Babyeater ship and the newcomers. Then the holo zoomed in, to show - - the most grotesque spaceship that Akon had ever seen, like a blob festooned with tentacles festooned with acne festooned with small hairs. Slowly, the tentacles of the ship waved, as if in a gentle breeze; and the acne on the tentacles pulsated, as if preparing to burst. It was a fractal of ugliness, disgusting at every level of self-similarity. "Do the aliens have deflectors up?" said Akon. "My lord," said Lady Sensory, "they don't have any shields raised. The nova ashes' radiation doesn't seem to bother them. Whatever material their ship is made from, it's just taking the beating." A silence fell around the table. "All right," said the Lord Programmer, "that's impressive." The Lady Sensory jerked, like someone had just slapped her. "We - we just got a signal from them in human-standard format, content encoding marked as Modern English text, followed by a holo -" "What?" said Akon. "We haven't transmitted anything to them, how could they possibly -" "Um," said the Ship's Engineer. "What if these aliens really do have, um, 'big angelic powers'?" "No," said the Ship's Confessor. His hood tilted slightly, as if in wry humor. "It is only history repeating itself." "History repeating itself?" said the Master of Fandom. "You mean that the ship is from an alternate Everett branch of Earth, or that they somehow independently developed ship-to-ship communication protocols exactly similar to our -" "No, you dolt," said the Lord Programmer, "he means that the Babyeaters sent the new aliens a massive data dump, just like they sent us. Only this time, the Babyeater data dump included all the data that we sent the Babyeaters. Then the new aliens ran an automatic translation program, like the one we used." "You gave it away," said the Confessor. There was a slight laugh in his voice. "You should have let them figure it out on their own. One so rarely encounters the apparently supernatural, these days." Akon shook his head, "Confessor, we don't have time for - never mind. Sensory, show the text message." The Lady Sensory twitched a finger and - HOORAY! WE ARE SO GLAD TO MEET YOU! THIS IS THE SHIP "PLAY GAMES FOR LOTS OF FUN" (OPERATED BY CHARGED PARTICLE FINANCIAL FIRMS) WE LOVE YOU AND WE WANT YOU TO BE SUPER HAPPY. WOULD YOU LIKE TO HAVE SEX? Slowly, elaborately, Akon's head dropped to the table with a dull thud. "Why couldn't we have been alone in the universe?" "No, wait," said the Xenopsychologist, "this makes sense." The Master of Fandom nodded. "Seems quite straightforward." "Do enlighten," came a muffled tone from where Akon's head rested on the table. The Xenopsychologist shrugged. "Evolutionarily speaking, reproduction is probably the single best guess for an activity that an evolved intelligence would find pleasurable. When you look at it from that perspective, my lords, my lady, their message makes perfect sense - it's a universal friendly greeting, like the Pioneer engraving." Akon didn't raise his head. "I wonder what these aliens do," he said through his shielding arms, "molest kittens?" "My lord..." said the Ship's Confessor. Gentle the tone, but the meaning was very clear. Akon sighed and straightened up. "You said their message included a holo, right? Let's see it." The main screen turned on. There was a moment of silence, and then a strange liquid sound as, in unison, everyone around the table gasped in shock, even the Ship's Confessor. For a time after that, no one spoke. They were just... watchin...

Nara Ford (IG: @TheNaraFord) is a 7 year veteran of the United States Air Force and one of the World's top content creators on OnlyFans. Subscribe to Nara's OnlyFans for free: https://onlyfans.com/action/trial/r6ajkkanwjm1qj4mkvqru4e4movncj8w Learn more about Michael's Men of Action Mentoring Program: https://go.moamentoring.com/i/2 Subscribe on Youtube: https://www.youtube.com/user/MichaelSartain Listen on Apple Podcast: https://podcasts.apple.com/us/podcast/the-michael-sartain-podcast/id1579791157 Listen on Spotify: https://open.spotify.com/show/2faAYwvDD9Bvkpwv6umlPO?si=8Q3ak9HnSlKjuChsTXr6YQ&dl_branch=1 Filmed at Sticky Paws Studios: https://m.youtube.com/channel/UComrBVcqGLDs3Ue-yWAft8w 0:00 Intro 0:44 Pamela Anderson with RoboCop arms 1:41 Tattoo removal on your inner thigh 2:30 Attractive females in the military 3:47 Catty women in the military 4:53 Punching your O card and E card 6:25 Stripping at the Rhino while in the military 8:40 Free boob jobs in the Air Force 9:53 Spearmint Rhino billboard 11:29 Getting an article 15 for stripping 12:18 Managing a strip club while in the military 13:18 Going in front of a two star general 15:44 Previous marriage 16:18 Transitioning out of the military 17:44 Basic training at Lackland Air Force Base 18:47 Originally from Orange Shores, Washington 20:24 I don't know my dad so I'm an only fans porn star 21:11 I need some discipline in my life 22:41 Discipline in the military 24:40 You look like Ajax from Mortal Kombat 26:57 Tattoo artist who just got out of prison 27:56 Old white men with money 29:21 Killing it at the Rhino 30:00 Getting into real estate 31:12 Switching over to OnlyFans 33:17 Building a house to film content in 34:22 Drinking while stripping 36:04 OnlyFans and stripping at the same time 37:01 JOI, Come eating instructions 38:25 The first time you upload hard-core porn 39:29 First anal video and pegging partner 43:04 Vulgar captions on only fans 44:34 How much more did the dildo video make? 45:35 How much more did the B/G video make? 47:51 What type of video pays the most? 49:23 “Mom, turn the video off.” 50:34 Anal and BBC 51:23 Finding women to collab with 53:20 Nara is testosterone level 55:20 *People at intimidate by me 56:50 Brazzers vs OnlyFans 57:45 AVN awards 58:24 Everyone has a type 58:50 Evolutionarily psychology, Sexual preferences 1:00:18 Belching and farting on OnlyFans 1:02:15 Come Eating Instructions 1:02:33 Boy/Girl/Girl Videos 1:04:45 A girl changed her mind 1:05:29 First Time Hard Core 1:07:07 Favorite people to work with 1:07:58 Incredible wingman, Dr David Buss 1:10:25 Favorite photographer 1:13:13 People you don't like working with 1:14:43 Insecurities 1:19:16 Unconditional love 1:19:50 OnlyFans isn't the problem 1:22:07 Don't do it unless you're comfortable with it 1:22:50 What happens when you film with another guy? 1:24:23 Looking for someone to Peg 1:24:48 Dating with Instagram and OnlyFans 1:26:35 Who would you like to work with? 1:27:34 Monogamy 1:30:09 Animal sanctuary 1:31:41 Monday's Dark Charity 1:33:39 Outro

Did you know, a dog could detect a teaspoon of sugar in a million gallons of water – that's two Olympic-size swimming pools! With that kind of superpower, it is no wonder we rely on them to keep us safe every day in ways you may not even realise. Why is your dog's nose a superpower? With up to 300 million olfactory receptors in their noses, compared to about six million in humans and a sense of smell that is about 100,000 times more sensitive than us, there is no doubt a dog's nose is a superpower. But why? Evolutionarily a dog's sense of smell helps them find a mate, locate their puppies, food, and avoid predators. But for decades they have also been helping to save human lives by putting their noses on the line all in the name of duty. From detecting danger to diseases to a new frontier, which we will explore, dogs are helping to keep humans safe and save lives, all in a days' work. Journey through this episode as we uncover the intricate make up and incredible reasons a dog holds such power on the tip of its snout. About Frank Romano, Golden Gate K9 Detector Dog School Frank Romano is a retired K9 Officer/Departmental and a K9 Trainer/CEO-Master Trainer at Golden Gate K9 which specializes in the training and maintenance of Police Service Dogs, Detection Dogs, and Personal Protection Dogs. He also trains family dogs for pet owners, Detection Dogs for businesses and as a team sport for fun. He is also owner operator of Dogfather K9 Connections, a 17 Acre Dog Ranch which contains a 35 commercial dog kennels, 8 large exercise/ break areas, multiple training fields/sites, a swimming pond, private dog park, pet taxi, and grooming salon. Golden Gate K9 http://www.goldengatek9.com/index.html Dogfather K9 Connections http://www.dogfatherk9connections.com/about.html LinkedIn https://www.linkedin.com/in/frank-romano-20b3654b/ About Ryan Llera, Veterinarian Dr Ryan Llera is a small animal veterinarian in Kingston, Ontario. Originally from Florida, he married a Canadian who is also a vet, and they have a daughter. They share their home with an English Springer Spaniel and Australian Shepherd mix (who are both into competitive scent detection), 2 cats, 1 rabbit, and 1 horse. He has a primary interest in endocrinology (diabetes, thyroid disease, etc.), dentistry, and especially surgery (including non-routine procedures). Blog https://drryanllera.com/ Facebook https://www.facebook.com/DrRyanLlera Twitter https://twitter.com/DrRyanLlera Instagram https://www.instagram.com/drryanllera/

A Mermaid is a mythical aquatic creature with the upper body of a female human and the tail of a fish.  Legends of these creatures have been reported since the beginning of humanity. There is no evidence that mermaids live anywhere on earth. However, there are a lot of scientific reasons why they physically cannot exist. Seriously, fish and human's last common ancestor was over 170 million years ago. If you're going to say mermaids are mammals, they'd have to breathe air, which means going to the surface often. (So lots of chances for humans to spot them).  AND even then, a human/water mammal would not have had time to evolve. Whales returned to the ocean 50 million years ago, and humans evolved 300,000 years ago…. So there is just not enough time for evolution to take place.But, there is a lot of interesting folklore surrounding these creatures. (A lot more interesting than the bigfoot ‘folklore') Tails of merfolks go back to ancient times: from the 2500BC Mesopotamia to the first know tale of an Assyrian queen who turned into a mermaid in 1000BC to current culture.  So, to say mermaids have been in the human psyche forever, would not be in error. Listen now to learn why mermaids cannot happen in real life, but are interesting anyways. For more information on us, visit our website at betterthanhumanpodcast.comFollow us on Twitter @betterthanhuma1on Facebook @betterthanhumanpodcaston Instagram @betterthanhumanpodcasthttps://www.tiktok.com/@betterthanhumanpodcastor Email us at betterthanhumanpodcast@gmail.comWe look forward to hearing from you, and we look forward to you joining our cult of weirdness!#betterthanhuman #cultofweirdnes

Touch is so powerful, more so than we think.. Evolutionarily, it is the most important way that mammals communicate safety to one another and as such, a touch has been shown to lower stress, alter heart rates, reduce anxiety, and promote calm. So what does the mean for our mental health and how can we us it to our advantage? We discuss on today's show. This episode references the following article: https://www.healthline.com/health-news/how-touching-your-partner-can-make-both-of-you-healthier#Touch-and-comfort-are-innate

4:39 "Rock bottoms come in any way, but they're always an invitation to realign with your actual path.' Are you ready and willing to be who you actually are, sometimes at the cost of belonging? The path chosen for us may have ups and downs, it may even be isolating during some seasons, but each challenge builds your character and further refines you into the ultimate person, the perfect puzzle piece for your future relationships. 6:17 "If you are turning down your volume to avoid chaos, you're internalizing chaos." There is no hiding. The challenge is within. Therefore, it's best we express our true authentic selves. If it creates discord, then it's a challenge we're meant to overcome within our relationships, friendships, and maybe even our community. Burying it down deep serves no one. 3 things people can do to ignite harmony in their relationships: Number 1: 10:19 "Recognize that your relationship is separate from who you are." You have needs that you must meet. Many of those come from an array of activities and relationships. Number 2: "See every relationship as sacred." The things that go unspoken and unprepared like plaque can build up into bigger problems. Number 3: "Define yourself." What kills relationships is the lack of recognition that you have sovereignty in your own life of yourself , deconstruct all of the systems that create codependency in your relationship. We can't allow someone else to "complete' us. We must be whole in ourselves. 18:18 "Evolutionarily, women needed to learn how to be safe around male aggression." It seems women seem more comfortable in personal relationship development and this may have been an evolved skill. 19:33 "We're more likely to get remarried, we don't know how to manage the grief and the pain, we have hardly any capacity for shame." Men seem to struggle with the shame of divorce and resort to remarrying to move on quickly. There's a difference between healthy shame and unhealthy shame. Instead of believing I'm no good, I can say "there's a better version of me available and I get to choose to step into it." 20:45 "When a man loses a relationship, he's generally losing his emotional support. For women, they turn mostly towards their friends." Men tend to replace their friends with their spouse, maybe for the purpose of organization or consolidation. So when a relationship ends, the man has lost more of his foundation. If your partner leaves, and you feel like they've taken everything, ask yourself "what did you give them?" If your happiness rests on their staying or going, then the weight they have to carry to be with you is too much. 22:50 "A relationship should never complete you. It should enhance you and make you a better person, and invite you to be a better person." 32:46 "The soul's journey will always try to express itself and ask for you to listen." 37:36 "There's only 3 constants in life. One is the sun will always come up, the moon will be there, and the truth will always be present." 38:55 "There's no such thing as one way liberation. If you are liberated, the other person is too, whether they know it or not." "Why would you ever choose someone who isn't choosing you? You can love someone and also not tolerate their behavior." 41:29 "When we're asking 'why the addiction?' We're asking the wrong question. We should be asking 'why the pain' and that's true of all materialism." Stress creates inflammation and poor relationships create stress. If you can figure out how to improve your relationships, it's the most important thing that you will ever change. "43:15 "If you do quit sugar, you'll probably discover that there was probably grief below." 50:52 "Every time you do something in excess, you are treating the pain of being present within yourself." 52:52 "When you draw a circle to exclude me, i draw a bigger circle to include you., and that's our work." 58:50 "Beliefs become our prisons, the idea that you can't do something, someone else's fear becomes our fear." Harriet Lerner Ph.D. - The Dance of Intimacy Bronnie Ware - Top Five Regrets of the Dying: A Life Transformed by the Dearly Departing https://createthelove.com/ https://markgroves.com/ Download the Mine'd app at https://www.doyoumined.com/   Follow Drew: @Twitter https://twitter.com/drewcanole @Instagram https://www.instagram.com/drewcanole/ @Facebook https://www.facebook.com/people/Drew-Canole/100044261357988/ Visit www.mysoulcbd.com/drew and get 15% off your next order!

The "Western World" has trained most who live here to feel as if monogamy is natural and normal: that it's "just the way thigs are." But humans are not wired up to live in monogamous frameworks. Evolutionarily, we fit somewhere between monogamy and polyamory, and our history as a species makes it easy to recognize why.  This week's episode is all about polyamory (poly: many, amor: love). My guest is Dr. Stephanie Webb, whose book, Use Your Words: Opening Language for Open Relationships, examines the link between cultural norms, language and polyamory. Like many things in US culture, love is policed in ways we seldom talk about and hardly notice. The feeling of, "that's just the way things are" is the result of being covertly taught what love can and cannot be. 

Is there a link between sex and happiness? Does having MORE sex with your partner mean you are guaranteed a more loving marriage?  If you are having “intimacy” issues in your marriage, does that mean you're doomed for failure? I LOVE this topic! And I am thrilled about this conversation with the brilliant, Randi Levinson. Randi is a Couples Therapist and Certified Clinical Sexologist. She helps couples find a deeper, more meaningful connection; better communication, and better more fulfilling sexual experiences. Randi considers herself to be beyond lucky to have studied with the best therapists in the world. She has been trained by Esther Perel, author of Mating in Captivity and The State of Affairs. Ester Perel is one of the many therapists that has given Randi invaluable guidance in her work with couples.  We will discuss how aging, loss of desire, loss of desire for your partner, resentment build up, disconnecting fights, contempt, boredom, defensiveness, stonewalling, and criticism play into how we move away or ‘grow apart' from our partners. All this and more, today on Doing Relationships Right. Highlights: The importance of seeing a Sexologist before Marriage Embarrassment over Sexual Issues  Importance of Communication During Sex  Is Masturbation Important?  Is Porn Addicting?  Is there a Link between SEX and Happiness?    Where to find Randi: Website: http://www.randilevinson.com/   Join the Facebook Group and leave a question for a future episode: https://www.facebook.com/groups/doingdivorcerightpodcast   Where to find me: Website: https://jenniferhurvitz.com/ Facebook: https://www.facebook.com/jenniferhurvitzbiz/   Watch the episodes on YouTube: https://www.youtube.com/channel/UC7ilFqf18-z-H_e7JFIrjbQ   You can connect with my editor, Next Level Podcast Solutions at https://nextleveluniverse.com/   Get a copy of Jen's book, “Woulda, Coulda, Shoulda: A Divorce Coach's Guide to Staying Married” here.    Show notes: [1:35] How Randi started her journey [3:34] Do we recommend talking to a sexologist before getting married? [7:10] Embarrassment over sex priority and incompatibility in sex desire [11:37] The importance of communication in sex [14:57] Check out this great parenting tool: Soberlink (https://www.soberlink.com/) [17:19] Put your spouse first [18:00] Exercise your vulva and sex toys [23:33] Evolutionarily speaking, women can find pleasure whenever she wants to [25:29] How much sex can sustain a happy marriage? [27:23] Stop and turn towards your partner instead of the other way around [29:15] Where can you find Randi?

Every single cell in your body is wired for fear. Evolutionarily speaking, it's what kept us as a species alive for thousands of years. What you don't realize, is that this fear exists subconsciously, flying under the radar and maintaining quiet control over so many of your emotions, and thus your reactions to the world. Embodiment is the practice of noticing the sensations in your body, then checking the accuracy of those sensations against the inarguable truth that at this moment, you are safe. By intentionally, curiously observing what's going on in your body, you can escape the narrative being built in your mind. You can logically observe those sensations before they become big emotions, and with Grace, let them go.

For the first time ever, Luke and Jarod are both unprompted and invite a guest, Sheng-Jie, to bring a topic. Three guys talk about what game theory is, offer historical examples, and how it can be applied to everyday life. Links to stuff we talked about: https://en.wikipedia.org/wiki/Nash_equilibrium https://plato.stanford.edu/entries/game-theory/ https://blog.thecenterforsalesstrategy.com/burn-your-ships-how-to-be-a-great-leader https://www.youtube.com/watch?v=NdITTDl5coE https://en.wikipedia.org/wiki/The_Selfish_Gene https://en.wikipedia.org/wiki/Evolutionarily_stable_strategy https://psyche.co/ideas/what-jibes-about-caesar-tell-us-about-sex-in-ancient-rome https://en.wikipedia.org/wiki/Pederasty History Correction: Jarod said that sexual relationships between adults men and young boys were not really present in classical Greece, but mainly in Rome. This was not the case, these relationships "originated" in Greece and the practice spread to Rome through Greek influence.

The current war in the holy land represents a battle between old and new, Evolutionarily speaking --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/sahibradio/support

Ztime Podcast We discuss: Why self-compassion can be evolutionarily useful Emotional Wellbeing, Physical wellbeing, relationship wellbeing, financial wellbeing, community wellbeing. Dr. Andres Zuleta, Andres Zuleta MD, Dr. Zuleta Diabetes and obesity epidemic. Diabetes remission, Type 2 Diabetes How did we get to this obesity epidemic Dietary goals for the United States, Daily inspiration. This study showed the truth behind eating less

When you look at immunity, you're looking at wellness. Immunity is about peak optimal performance; that your needs are met, you're not stressed or anxious, and you're able to focus. I think animal wellness supports that in terms of providing optimally nutrient dense food and with minimal inflammation. Our immune system is compromised when we're inflamed and inflammation comes primarily from junk that's in our food. Eating whole, high nutrient dense, and anti-inflammatory foods is so important for boosting immunity. - Anya Fernald   Get 15% off your CURED Nutrition order with the code WELLNESSFORCE   ---> Get The Morning 21 System: A simple and powerful 21 minute system designed to give you more energy to let go of old weight and live life well.   JOIN THE FACEBOOK GROUP | *REVIEW THE PODCAST* Wellness Force Radio Episode 393 Co-Founder and CEO of Belcampo, Anya Fernald, shares her mission to revolutionize the meat industry from the inside out, explains how ethically raised meats can boost your immunity while also helping the planet, and explores our spiritual and emotional connection to food.   How do we create and consume animal products that are good for people, the planet, and the animals themselves?     Join us as Anya shares her mission with Belcampo to revolutionize the meat industry by farming meat the right way with regenerative agriculture and positive climate practices.   Belcampo Farms Get 20% off of your first Belcampo order with the code WELLNESSFORCE Belcampo was founded with a purpose: to create meat that’s good for people, planet and animals. What started as one mom’s desire to feed her family the healthiest meat possible became a mission to revolutionize the industry from the inside out. Belcampo is the pioneer of hyper-sustainable, organic, grass-fed and -finished, Certified Humane meats, broths, and jerkies. The company is on a mission to revolutionize the meat industry for the well-being of people, the planet, and animals by farming meat the right way – with Certified Humane, regenerative, and climate-positive practices, which means it’s better for you, the planet and the animals. Conventionally raised animals are confined to feedlots and eat a diet of inflammatory grains, but Belcampo’s animals graze on open pastures and seasonal grasses resulting in meat that is higher in nutrients and healthy fats.     Listen To Episode 393 As Anya Fernald Uncovers:   [1:30] Meat You Can Feel Great About Eating Anya Fernald Belcampo Food Network | Anya Fernald What Belcampo and its mission means to her. Her background in food and how she came to be a artisanal cheesemaker in Italy. Obstacles and changes she faced as an expat in Italy for 8 years. The ambitious drive that led her to get out of her comfort zone and seek work outside of the US. Her own personal health shift in Italy compared to how she felt when she lived in the US and had struggles with moodiness, dry skin, split ends, and cavities. Unpacking the slow food movement that Italians live by compared to other countries. What food actually means for our physical, emotional, and spiritual health. Why good food doesn't necessarily mean it's been prepared by a professional chef but that it is clean and both whole ingredients and methods have been used. The importance of slowly growing our food, using micronutrient rich soils, and being mindful about consumption. How she has become such a strong leader for Belcampo by tuning into her intuition, speaking her truth, and being driven by their mission.   [19:00] Revolutionizing Meat: People, Planet & Animals 357 Robb Wolf The fundamental ethics that Belcampo stands behind with the treatment of their animals including raising them outdoors to support their customer's wellness. Why it's so important to raise animals in a way that is aligned with their own evolutionary context. Unpacking this fight between ethical consumption of meat and people who don't believe in eating meat. How PETA harassed her for two years including one time when she was giving a talk while also 9 months pregnant. Why PETA's question to her, "Would you eat your dog?" doesn't even make sense from a pathogen perspective as dogs are carnivores. The empathy that she has for people in PETA and why she believes their success is her success because they are fighting for the same thing: the end of animal confinement in agriculture. Belcampo's positive impact on agriculture yet the amount of grass-fed and finished farms is still less than 1%. Why many of the vegan movement messages are correct when it comes to confinement agriculture.   [27:30] Food's Connection To Spiritual and Emotional Health 376 Mike Salemi  How humans have lost the instinct to seek out whole foods as our sense of smell has decreased with the use of food packaging, processed ingredients, and marketing. Her mission to give people a product that smells amazing, has a great story and you can both connect with and feel good about purchasing. The challenge that she has for the health and wellness movement now with the simplification that food is fuel or that protein is protein powder to the point that it's playing the agroindustrial game. Why adding mindfulness to food can help us win against the agroindustrial game of processed and poorly raised, grown, or created food. Unpacking the fact that the most uncommon food to eat comes from pigs because of it being an omnivore and fear of getting sick from something such as trichinosis. Why it doesn't make sense for humans to eat carnivorous animals because they have a very similar microbiome to us and any parasites they may carry could then live in our guts. Her life as a vegetarian and experiencing poor skin conditions, low energy, weight gain, and depression  for almost 10 years before adding meat back into her diet when she moved to Italy. How she got into artisanal cheese making after being a traditional baker using whey. Why she's not anti-vegetarian and believes it works great for some people, it just didn't work well for her body.   [32:30] Healing Energy From Ethical Meats The fact that a lot of raw meat is often eaten in northern Italy and thus it became a regular part of her diet while she lived in that area and felt great because of it. How her health got worse when she came back to the US as she gained a lot of weight, felt lethargic, was grumpy, and had brain fog. Exploring how her focus on better health for herself helped launch the start of Belcampo. The real cost of food and why it's affordable to eat grass-fed and finished meat such as that from Belcampo. Unpacking the truth about organic and the hidden costs of not eating organic food. Her own rules for buying organic foods for own household. Why cows are able to process and filter out toxins such as GMOs unlike fruits and vegetables. Exploring the slow movement of grass-fed, organic meat and why the health of these animals are important for your health too. How the amount of protein in her animals differs compared to conventionally raised meat. What meat labels you should look for at the grocery store: grass-fed and grass-finished, 100% grass-fed, and pasture-raised.   [40:30] The Issues With Raising Conventional Chickens Joel Salatin 362 Zach Bush MD The fact that most common medicine in the US is antacid and most people have GI issues. Why it's so important to pay attention to what our bodies are telling us if we eat foods that make us feel sick. How eating meat again was an important piece of Anya's gut feeling better again. The fact that the third largest greenhouse gas emitter is meat that we throw away as we overproduce meat that is raised in extremely poor conditions. Why pricing is an important factor in being mindful of what we buy and put into our bodies. Exploring the impact of raising chickens either the conventional or natural way Morgan Spurlock - SUPER SIZE ME 2 Official Trailer - Holy Chicken The fact that conventional chickens can be processed by being bathed in chlorine and pumped up to be sold at higher prices with less nutrient value.   [47:30] How Conventional Chicken Is Raised In Stressful Environments Why chicken can be really complex as we our meat consumption of it is 60% and it is the most changed as far as pricing and perceived cultural value in the past 6 decades. How the high-stress environment that chickens are raised in and continuous exposure to antibiotics suppresses their microbiome and leads to rapid weight gain. The fact that some chickens are under so much stress from being kept to lay eggs to forced molting in their environment. The Meat Racket: The Secret Takeover of America's Food Business by Christopher Leonard The horrible conditions that some people work in and how it can also impact those who live nearby the farms. Why you should go for pastured, organic, air-chilled chicken if you are going to buy it. What happens when you degut an animal and why contamination is low for beef but high for chickens. The fact that on average even USDA approved chicken, 48% of them have some fecal matter on them. Doctors Sue USDA for Ignoring Concerns Over Fecal Contamination of Chicken How to know if your chicken has been dunked in a bleach bath because a gooshy, white liquid solution will come out.   [53:30] Ethical Meats & Immunity How to build and boost your immunity with ethical meat consumption. Why a lot of our gut health issues have to do with a the glyphosate, antimicrobials, and bleach that is in our food. The fact that all flour is now treated with antimicrobials because of the issues with E.coli. Why you might not be intolerant to gluten but have a strong reaction to antimicrobials in your food. How the strong antiviral and antimicrobial sprays on planes while traveling has affected her gut health lately. The power of nutrient dense foods to boost our immunity and wellness. Why bloating and holding onto water is a sign that there is inflammation in the body. 365 Dr. Paul Saladino The fact that most people who start eating higher amounts of animal proteins reduce their inflammation and physically look less puffy. Anya's experience following a strict carnivore diet and the healthy benefits she received from it but why she isn't following it in the long term. Why not everyone's body can handle a ton of fruits and vegetables and so they find that a meat-based diet is better for their bodies. The problem the US is facing with land that is not sustainable for growing crops yet animals can still graze on them and help redistribute seeds. Historical records of agriculture and the planting of crops that have succeed and failed such as from the Great Depression and the Dust Bowl eras. The Worst Hard Time: The Untold Story of Those Who Survived the Great American Dust Bowl by Timothy Egan   ] [1:06:30] How Anya Has Become A Leader For Women In Business The biggest trigger that Anya has faced: Being dismissed as somebody who is good at marketing. Why she doesn't waste her time worrying about the other competition. How they've determined their prices based on their cost and allocation of resources. Why she focuses on spending every single moment of the day taking care of herself or making things better for her company and employees. Words of wisdom she wants to pass on women who also work in the world of business. How social media has helped her rediscover herself as an authentic leader. The feminine characteristics she is proud of in addition to being a boss. Why eating ethical meats helps us balance our masculine and feminine energies. Breaking down why healthy animal protein does allow you to have more vital femininity. What wellness and self-care practices she has invested in for personal growth and self-discovery. The benefits she has received from having a mentor to help and guide her path. Start With Why by Simon Sinek breathwork.io M21 Wellness Guide Wellness Force Community   Power Quotes From The Show Clearing Out GMOs, Bleach, & Antimicrobials In Our Food   "A lot of the issues that we have with digestion have to do with the glyphosate, bleach, and antimicrobials that are in our food. For example, all flour is now treated with antimicrobials because of the E.coli issues so you don't get sick if you eat raw cookie dough. So, when people think they're intolerant to gluten, they may actually be reacting to a strong antimicrobial that their food is infused with. From an immunity perspective, clearing out glyphosate, bleach, and antimicrobials in our food is the number one thing to do." - Anya Fernald   The No. 1 Rule About Eating Organic Foods "There are certain things I will never eat if they are not organic and that is anything that has a very thin skin and no protective exterior membrane. So, something like a blueberry, a strawberry, zucchini or lettuce. Avocado? No problem; I'll eat a non-organic avocado. Corn occasionally? Sure; It has a husk. If there's a cabbage that's not organic, I'll peel off the exterior sections before eating it but that's not my everyday choice. Be rational - the thinner the membrane as well as the sweeter it is inside, the more careful you need to be about organic foods. What about meat? These animals have all these organs that make them great at processing and filtering out toxins. Will you get glyphosate from a cow that ate GMOs? No way; you can't make a better machine that is able to filter out toxins than a cow but eating organic animals is more about being the change that you want to see in the world." - Anya Fernald   Human Wellness Is Supported By Animal Wellness   "From a fundamental integrity perspective, the most important factor of ethical meat is to raise the animals outdoors. This is a key piece to human health. Evolutionarily, human wellness is supported by animal wellness. We need to look at systems that allow animals to live in an evolutionary context; in systems that are aligned in a way with their own evolution." - Anya Fernald     Links From Today's Show  Food Network | Anya Fernald 357 Robb Wolf 376 Mike Salemi  Joel Salatin 362 Zach Bush MD Morgan Spurlock - SUPER SIZE ME 2 Official Trailer - Holy Chicken The Meat Racket: The Secret Takeover of America's Food Business by Christopher Leonard Doctors Sue USDA for Ignoring Concerns Over Fecal Contamination of Chicken 365 Dr. Paul Saladino The Worst Hard Time: The Untold Story of Those Who Survived the Great American Dust Bowl by Timothy Egan Start With Why by Simon Sinek Leave Wellness Force a review on iTunes breathwork.io M21 Wellness Guide Wellness Force Community Anya Fernald Facebook Instagram LinkedIn Belcampo Facebook Instagram Twitter YouTube   About Anya Fernald Anya Fernald is the Co-Founder and CEO of Belcampo. She is an entrepreneur, chef, and agriculture expert, appearing as a judge on the Food Network's Iron Chef America, Iron Chef Gauntlet, and The Next Iron Chef. After experiencing the positive effects that eating clean meats had on her own health–and recognizing the impact of the quality of life of the animals we eat–she set out on a journey to produce the highest-quality meats there are, both in the ethics of how they’re raised as well as pure deliciousness. Fernald was born on a raw-milk dairy farm outside Munich, Germany, while her parents were teaching and researching abroad. When she was 3 years old, her family moved back to the United States, eventually settling in Palo Alto, California. After graduating from Wesleyan University with a degree in political science, she received a Thomas J. Watson Fellowship, leading to work as an itinerant cheesemaker in Europe and North Africa. In November 2012, the first Belcampo Meat Co. storefront opened its doors in Marin County, California, following the opening of Belcampo Butchery, a 20,000 square foot, USDA-approved multi-species slaughter facility designed by animal welfare expert Temple Grandin, and a nearby 27,000-acre (11,000 ha) farm. It has butcher shops and restaurants in Los Angeles, Marin, Santa Monica, San Francisco, San Mateo, Oakland, and New York. Belcampo also sells meat in Erewhon Grocery Stores. Fernald co-founded the company and serves as its CEO.   Build Immunity. Breathe Deeply. A simple, powerful 21 minute morning system designed to give you more energy to let go of old weight and live life well. Get Your Calm Mind + Immunity Building Guide  *6 science based morning practices guaranteed to give you more energy and less weight in 21 Minutes. *7 day guided B.R.E.A.T.H.E breathwork included.   More Top Episodes 226 Paul Chek: The Revolution Is Coming (3 Part Series) 131 Drew Manning: Emotional Fitness 129 Gretchen Rubin: The Four Tendencies  183 Dr. Kyra Bobinet: Brain Science 196 Aubrey Marcus: Own The Day 103 Robb Wolf: Wired To Eat Best of The Best: The Top 10 Guests From over 200 Shows Get More Wellness In Your Life Join the #WellnessWarrior Community on Facebook Tweet us on Twitter: Send us a tweet Comment on the Facebook page Watch full interviews on YouTube

Today on the Finance Flash Go! podcast, we are talking about analysis paralysis. Analysis paralysis can seriously impede our ability to make progress in our lives. Personally. Professionally. Financially. With friends, family, colleagues. The list goes on and on… It is also super common. I have never asked one person who hasn't admitted to suffering from analysis paralysis in one form or another. And it is hard to resist. Evolutionarily, analysis paralysis makes sense. We are a loss adverse species in which losses hurt a lot more than wins give us pleasure. We are hardwired to scrutinize the decisions we make with an emphasis on not making the wrong one. And that is what the driving force of analysis paralysis is…fear! How often have you seen someone who is deciding between two good things? It really can be anything. Maybe it's something serious like the decision to pay down debt or invest in index funds…both options are great. The key to overcoming is trusting yourself. You need to learn to trust yourself. You will know what the right move and decision is. Your heart or gut or soul or whatever you want to call it will be telling you. Meanwhile, your cavewoman brain will still be wrestling to try and protect you. Like so many things in this world, analysis paralysis is not one of those things that you conquer once and for all. It's a constant effort. But it does get easier. Once your have developed the tools, you become more adept at implementing them when the time arises. Please enjoy the Finance Flash Go podcast! We plan to release a new episode every weekday answering important finance questions. If you ever want to submit a question to our podcast, send an e-mail to financeflashgo@gmail.com, and please be sure to check out Jordan Frey's blog prudentplasticsurgeon.com where he gives great financial advice. A brief disclaimer While we are providing knowledge and awareness around financial topics in this show, we are not held responsible for any financial decisions you choose to make in response to the podcast. We hope to provide accurate information in regards to money and different methods of wealth creation, but it is always the learner's responsibility to due their due diligence before making important financial decisions. We hope you enjoy the show and thanks for tuning in, and if you like the podcast please subscribe, share, and leave us a review on the podcasting platform of your choice!

So That You May Have Life John 20:19-31 Will Ed Green—Sunday, April 11th, 2021—Foundry United Methodist Church Good morning, friends. My name is Will Ed Green, and I serve as one of Foundry’s Associate Pastors and our Director of Discipleship. As we move into a time of reflecting on Scripture together we are so glad you’re with us. For those of you who are just tuning in, you’ll find links for fully engaging in our service in our Facebook and YouTube comments or on our website www.foundryumc.org. If you are in need ASL interpretation, we invite you to join us at www.foundryumc.org/asl. So I want to begin this morning by talking about the “Apophthegmata Patrum,”—no, that wasn’t a sneeze, I said “apophtegmata patrum.” They are the recorded sayings of a group of monks and nuns known as the Desert Mothers and Fathers. They lived in caves, mud huts, and even holes they dug in the ground in the deserts of Egypt, Syria, and Palestine; sometimes in small communities but, more often than not, alone. There, in the desert, with the busyness of life and the clutter of consumption cleared away, they embarked upon a bold endeavor: through prayer and contemplation, to live more humanely, to become—in modeling their life after Jesus—more human, and thus to become truly alive in the love of God. The “Apophthegmata”are snippets of stories and parables—preserved from the their own self-reflection, or offered to their disciples and visitors, that often begin with the question: “Amma, Abba, give me a word.” Their responses are not theological treatises or Christian self-help one-liners. They are plain and practical; unconcerned with right belief or theology and focused on matters of the heart. This simple wisdom cleaves performative spirituality and self-righteous theology from the practical matters of daily discipleship.  And because of this, they force us to address the ways what we profess is actually transforming our hearts and lives. Something John Wesley might have called “personal holiness” or “sanctification.” During these Great 50 Days—or the 50 days between Easter and Pentecost—our new sermon series invites us, like the Desert Mothers and Fathers, to focus our attention on the work of being and becoming alive. To receive in the fullness of its power the hope of the resurrection we proclaim. To embody, not just in right belief, but in the daily rhythms of our lives the freedom and abundance of life available when we live as those who believe that Jesus IS risen. So now, as we turn to the words of the Living Word, Jesus, and ask of them as those who traveled to the desert so long ago: “Give us a word” let us pray: Order our lives in your Word, O God, that everything we do may bear witness to your resurrection life.  Order our words in YOUR word, O God, that everything we say may bring life into a worry-weary world desperately in need of hope. Breathe the anointing of your Holy Spirit upon all those in the sound of my voice, that in this sacred space we now share together we might be transformed by your Living Word, and in that transformation might take our place in kin-dom work to which you’ve called us. And now may the words of this preacher, faulty and fleeting though they may be, fade into the background of the Word which you would have us receive this day. Amen. I want to begin this morning by acknowledging  that is a sermon about Jesus’ body and our bodies and the way they experience and express trauma. There may be moments when previous experiences of your own trauma rise to conscious awareness, so pay attention to your body. If you find yourself feeling anxious step away or pause and take a break, please know that’s ok. Today’s reading begins with the disciples in the throes of collective trauma. Their doors are barred in fear of what terror may yet occur. Just days before they witnessed their rabbi ruthlessly murdered, were denied by the disappearance of his body the familiar rhythms and rituals of mourning, and are certainly still trying to make sense of his promised resurrection in light of all these things. Suddenly, a surprisingly fleshy Jesus—given the doors to this kiki are locked tight—appears in the midst of their uncertainty, fear, and doubt. Showing his wounds. Speaking of peace. Breathing upon them. And it’s the revelation of his resurrected and scarred body—the text tells us—through which they see and know him for who he is, finally able to rejoice. But Thomas isn’t there to see the wounds and recognize the resurrection. And when told of what happened he insists that his belief will come only when he’s able to touch the wounds, feel the scars, and grasp hold of this body which held the trauma they’d all shared. When Thomas arrives, we’re not told whether or not he actually digs his hand into Jesus’ wounds, but it’s clear he’s given the chance to. And in this moment of direct confrontation with embodied sorrow and suffering—not just Jesus’ own, but that of the community who loved him— Thomas proclaims, “My Lord and My God,” finally able to see through those wounds the full promise of God’s resurrection power. John’s Gospel is the only one that makes the wounds of the resurrected Jesus central to the story, mixing the past pain and trauma of the crucifixion with the present rejoicing in and hope for resurrection. I find it fascinating that these encounters are precipitated by recognition of Jesus’ wounds. It’s not his miraculous appearance among them, not his face or voice, but his wounds that confirm his identity.  John’s Jesus isn’t a face-tuned, blemish-less, social media ready Savior fresh off a few days of rejuvenating rest in the tomb, but one who bears the marks of the cross and yet lives. Over the centuries we’ve conveniently made this a story about Thomas’s doubt. We love the image of one who must root around in the wounds of Jesus to achieve satisfaction—perhaps because we feel the need to excuse our own doubt or to satisfy ourselves with the thought that at least we’ve got more faith than THAT. But this reading also provides a convenient way to ignore the confronting an uncomfortable truth: resurrection doesn’t guarantee instantaneous healing. When the story is more about Thomas’ spiritual faults than wounds he insists on touching, we get to ignore that that resurrected Jesus still bears the marks of the tomb. The life he offers isn’t one in which our past trauma and sorrow is expunged. Instead, John’s resurrection body forces us to confront how they inform and are part of life. Healing cannot be separated from suffering. Resurrection cannot be separated from death. Let me pause and be clear here: this is not a sermon about redemptive suffering. As a pastor I wholeheartedly reject the idea that suffering is a somehow necessary part of the way we grow in faith or love of God and one another. This is bad theology—no tea, no shade, Paul…but maybe a little. And it’s the root of so many excuses for the continued mass incarceration, torture, and violence perpetuated against our black and brown siblings, too often one which traps women in cycles of abuse and neglect in the name of  “faithfulness,” and is regularly used against my queer siblings as they are subjected to theologies of self-loathing and the horrors of conversion therapy. But willingness to erase Jesus’ wounds and focus solely on Thomas’s doubt is dangerous. The wounds, and the pain they embody, can’t be overlooked. Far too many people are taught a theology of comparative suffering, where ‘good Christians’ are taught to minimize their suffering—or the suffering of others— because clearly other people have it worse than “you.” We are taught that our doubt, disbelief, heartache and hurt are an expression of faithlessness in God, that these don’t get to exist in tandem with life in a post-Easter world. Recent developments in psychobiology have given us a deeper understanding of how trauma impacts our brains and bodies. By trauma, I mean any experience which causes acute anxiety, fear, rage, or grief and that activates our desire to “fight or flee”. When this happens, a part of our brain, sometimes called the “lizard brain.” kicks into gear.  This ancient, built-in defense mechanism is tied directly our primary life systems, and can activate them before we consciously pick up on a threat. All of us, I’m sure, can remember moments of acute distress when our heart was pounding out of our chest, our breathing shallow, our palms sweaty, or our stomachs churning. Evolutionarily, these responses are meant to keep us alive until we can escape and process our experience. But what happens, when like the disciples, we encounter grief we can’t process or explain. A tomb left empty, holding more questions than answers. Night after night spent with the door tightly barred with no end to the threat in sight? Significant or repeated experiences of trauma, as author Bessel van der Kolk writes in “The Body Keeps the Score,” alter our perception of reality. We get stuck in the lizard brains, constantly reacting to something which our conscious brain might otherwise recognize as innocuous or inane.  Phrases like “Per my previous email” or “Can we talk?” can send us into fits of rage.  News notifications or unexpected phone calls can leave us panicked and breathless. Left unchecked, these trauma wounds impact nearly every aspect of our lives. We become stuck in cycles of self-sabotage; often in trying to prevent the threat of future trauma, inadvertently causing the very thing we fear.  In real moments of panic or danger, we become unable to distinguish those who want to help from those trying to cause harm, leaving us isolated and suspicious. These repeated trauma reactions build a new kind of knowledge in our bodies, changing the way we exist in and share space with others. Toxic anxiety—or prolonged periods of unabated anxiety—can kill us. Over time, our lizard brain’s over activation of our bodily systems can cause us to gain weight, makes hearts and arteries age abnormally, or our immune systems fail. We brains become so accustomed to our anxiety or the threat of trauma that we unconsciously create a world in which we constantly feel or create it because it’s the only way we know how to live.  One study comparing patients with untreated or significant past trauma to those without it, found that the brains of persons with PTSD literally shut down areas which control and help us define our sense of self in proximity to others. In an effort to erase their experience of trauma, our brains adapt, shutting off the parts of our brain that help us know perceive the world around us and know ourselves outside of our anxiety or fear of future pain or grief.           It’s no wonder it took Jesus miraculously appearing in their midst and revealing his wounds, rather than the words of Mary who encountered him just before, to recognize him. And that was just three days later. Thomas spent another week—another week!—living in that terror and fear. Jesus wasn’t the only one wounded in the story. He was just the only one who’s wounds we see. If you’ve ever read J.R.R. Tolkien’s “Lord of the Rings” trilogy, you might remember that goblins are sneaky, burrowing creatures who are terrified of light. Under the cover of darkness however, they leave their caves to wreak havoc and violence on unsuspecting victims, pillaging and plundering everything they can take. I have this image of our unnamed, un-healed trauma operating a little like these goblins. Our trauma goblins burrow just beneath the surface of our conscious awarenness and, hidden by our fear and shame about facing them, co-opt and corrupt our ability to distinguish between despair and hope, life and death, friend and foe. Left unchecked, they impact everyone around us. They change our ability to listen and respond to others. Our capacity to trust and show up authentically, to love and take worthwhile risks. They pillage the wealth of our relationships, our good intentions, and giftedness and in their wake often cause lasting harm to those we love.. But much  like Tolkein’s goblins are terrified of light, of being seen, our trauma goblins lose their agency over us when exposed to the light of conscious awareness. Trauma therapists now understand that the long-term trauma can only be dealt with in our bodies. Employing a variety of mind-body techniques like deep breathing, massage, yoga, and meditation allows survivors of long-term trauma and toxic anxiety to begin to understand how their trauma impacts their bodies, and through their bodies to begin learning what it means to regain control of their lives. By addressing the often-unconscious ways our anxiety and trauma is manifested in our bodies, we’re able to break its control over us. Perhaps this is why it took the wounded AND resurrected body of Christ to break the the coopting cycle of the disciples’ anxiety, fear, and self-doubt. Breathing new life and strength into bodies weary from trauma that never seems to end. Showing the wounds in all their pain and the promise that that there was yet life beyond them. And when that trauma misshaped and Mal-informed Thomas’s perception of himself and others, Jesus extended his hands, wounds and all, without reproach or shame, allowing Thomas to touch the source of his pain so that he might be free to live beyond its control. In her book Resurrecting Wounds, Shelley Rambo writes: “The truth of the resurrection conveyed through the symbols of [Jesus’] scars is that these textures (grief and joy, pain and pleasure) will always be present in life, often simultaneously. Interlaced with joy and pain, a life can be marked as holy even in all this ambiguity.” Jesus shows us how gentle acknowledgment and awareness of our trauma helps us recognize that God is present both in suffering and healing, in doubt and belief; liberating us from the lie that our past trauma and present wounded-ness is all there is to our story. The wounded and resurrected savior bears witness to the real resurrection promise: not that we will always be ok, or skate past suffering in life through slights of hand like comparative suffering, not some glorified, resurrected future free of all our past trauma and grief, but the freedom to see written in our marks our past trauma leaves that while life guarantees suffering and loss, God guarantees life despite of and beyond it. Social worker and author Resmaa Menakem notes in his book on racial trauma in America “My Grandmother’s Hands” that, “…we tend to think of healing as something binary: either we’re broken or we’re healed from that brokenness…but healing from trauma occurs [over a long time and] on a continuum.” If Thomas teaches us nothing else, he shows us that we do not need to be embarrassed or controlled our past traumas. His reach teaches us how to reject the temptations of comparative suffering, and gives us permission to be okay not being ok. To doubt. To be a hot mess express. His recognition and acclamation of the resurrection shows us that by naming our wounds they lose the power to define our experience of others and the world. In honoring our wounds,  in refusing to defer or delay our recognition of trauma, we bring into focus a reality too often denied by binary models of healing: that we can be both hurt and healing, broken and being made whole, in the tomb and yet returning to life.In that way, his demand to confront the wounds, to run his fingers over the still-fresh scars of the cruxifixion isn’t an act of doubt. But an experience of his own resurrection. And while Thomas may, in fact, offer us a lesson on doubt, he’s also showing us what it means, in light of the resurrection, to be and become alive. On my hands is a roadmap of my past only I can read. Here a deep scar, left when a frantic dash out the door pulled artwork off the wall that bit back. There an almost invisible pockmark from chicken pox long healed. Joints left crooked after broken bones, callouses left from picking up heavy things. They may not be pretty, but all those marks and scars on my hands remind me—in all their beauty and brokenness—despite it all I am still alive. Pentecost will mark the 19th anniversary of the first time I ever preached and publicly acknowledged my call to ministry. It will also mark the beginning of a profound and painful internal struggle with my God-given identity as a gay man and the ordination process of a church which actively told me that identity was incompatible with Christian teaching. There’ve been plenty of wounds along the way. Having to leave my home and family behind in order to be ordained in the church I felt called to. Living in fear of what would happen if a picture of my partner and I got posted on the wrong account or parishioners encountered me holding hands on a first date. Hiding my identity from my colleagues for fear it might be used against me in a court of…well, church law. Much like looking at my hands reminds me I'm still alive, every day I choose to name them, acknowledge, touch and know them reminds me that it’s ok that  I am healed and still healing. I am broken and almost being made whole. And that I am, in the words of that old Charles Wesley hymn, despite it all, yet alive.  The Abbas and Ammas of the desert often remark on the way has a funny way of entering in through the wounds we bear and slowly, imperceptibly, beginning the work of healing. And though I’m not sure I’ll ever stop fighting those old trauma goblins, God’s grace—new each day—gives me fresh hope that they don’t have to define what comes next. I know I don’t need to enumerate for you all the ways that we are these days, individually and collectively holding and bearing witness to trauma. But I do know that it’s okay to hold doubt in one hand and hope in the other. That in the light of the resurrection your scars and wounds aren’t proof of your failure or lack of capacity or worthlessness. No, they are proof you’re a badass. You can do and survive hard things. You already survived the worst moments of your lives. No one else has ever done that. No one else could. Best of all, I know that in the midst of all the trauma past, and all the trauma to come, we are accompanied by a Savior who’s love allows us the grace and space to know that—no matter how broken or wounded we may be—we are loved. And meets us in moments when they in all their death-dealing power threaten to overwhelm or overcome us with open arms, proclaiming peace and promising though our scars may remind us of where we’ve been, and what we’ve been through, they may inform but don’t have to dictate what comes next. I think that may be what it means to become in alive in God’s love. And, for now, at least for me, that’s resurrection enough. https://foundryumc.org/

Is there a link between sex and happiness? Does having MORE sex with your partner mean you are guaranteed a more loving marriage?  If you are having “intimacy” issues in your marriage, does that mean you’re doomed for failure? I LOVE this topic! And I am thrilled about this conversation with the brilliant, Randi Levinson. Randi is a Couples Therapist and Certified Clinical Sexologist. She helps couples find a deeper, more meaningful connection; better communication, and better more fulfilling sexual experiences. Randi considers herself to be beyond lucky to have studied with the best therapists in the world. She has been trained by Esther Perel, author of Mating in Captivity and The State of Affairs. Ester Perel is one of the many therapists that has given Randi invaluable guidance in her work with couples.  We will discuss how aging, loss of desire, loss of desire for your partner, resentment build up, disconnecting fights, contempt, boredom, defensiveness, stonewalling, and criticism play into how we move away or ‘grow apart’ from our partners. All this and more, today on Doing Relationships Right. Highlights: The importance of seeing a Sexologist before Marriage Embarrassment over Sexual Issues  Importance of Communication During Sex  Is Masturbation Important?  Is Porn Addicting?  Is there a Link between SEX and Happiness?  Where to find Randi: Website: http://www.randilevinson.com/ Join the Facebook Group and leave a question for a future episode: https://www.facebook.com/groups/doingdivorcerightpodcast Where to find me: Website: https://jenniferhurvitz.com/ Facebook: https://www.facebook.com/jenniferhurvitzbiz/ Watch the episodes on YouTube: https://www.youtube.com/channel/UC7ilFqf18-z-H_e7JFIrjbQ You can connect with my editor, Next Level Podcast Solutions at https://nextleveluniverse.com/   Get a copy of Jen’s book, “Woulda, Coulda, Shoulda: A Divorce Coach’s Guide to Staying Married” here.    Show notes: [1:35] How Randi started her journey [3:34] Do we recommend talking to a sexologist before getting married? [7:10] Embarrassment over sex priority and incompatibility in sex desire [11:37] The importance of communication in sex [14:57] Check out this great parenting tool: Soberlink (https://www.soberlink.com/) [17:19] Put your spouse first [18:00] Exercise your vulva and sex toys [23:33] Evolutionarily speaking, women can find pleasure whenever she wants to [25:29] How much sex can sustain a happy marriage? [27:23] Stop and turn towards your partner instead of the other way around [29:15] Where can you find Randi?

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.07.372805v1?rss=1 Authors: Voorhies, W. I., Miller, J. A., Yao, J., Bunge, S. A., Weiner, K. S. Abstract: While the disproportionate expansion of lateral prefrontal cortex (LPFC) throughout evolution is commonly accepted, the relationship between evolutionarily new LPFC brain structures and uniquely human cognitive skills is largely unknown. Here, we tested the relationship between variability in evolutionarily new LPFC tertiary sulci and reasoning skills in a pediatric cohort. A novel data-driven approach in independent discovery and replication samples revealed that the depth of specific LPFC tertiary sulci predicts individual differences in reasoning skills beyond age. These findings support a classic, yet untested, theory linking the protracted development of tertiary sulci to late-developing cognitive processes. We conclude by proposing a mechanistic hypothesis relating the depth of LPFC tertiary sulci to anatomical connections. We suggest that deeper LPFC tertiary sulci reflect reduced short-range connections in white matter, which in turn, improve the efficiency of local neural signals underlying cognitive skills such as reasoning that are central to human cognitive development. Copy rights belong to original authors. Visit the link for more info

Do you ever listen to that voice in your mind that judges and criticizes your every move? We all have that voice - or inner critic - and it can be relentless. Evolutionarily, our inner critic was there to keep us safe. In modern times, it tends to cause us more anxiety and drama than anything else. That's why it's important to understand, approach, and overcome our inner critic so we can learn from our mistakes, focus on the positive, and move forward in life.   In this episode of Love This B!tch, I am really going deep into why we have an inner critic, where it originated in our evolution, how you can practice awareness, and the steps we can take to overcome our inner critic and make it our number one cheerleader. Because we are all human - we all have flaws, we all make mistakes. And we all need to relate more kindly to ourselves.    Here's a closer look at What is the Inner Critic? [2:00] How the Inner Critic leads to mental and physical health issues [5:10] Why shame and blame are not good motivators [13:38] How to overcome your inner critic [13:40] Understanding that we are all human [End time]   Connect with Lisa: Website: https://www.lisaoglesbeecoaching.com/ Schedule a Connection Call with Lisa: https://app.acuityscheduling.com/schedule.php?owner=20041725&appointmentType=21324511 Instagram: https://www.instagram.com/lisaoglesbeecoachingllc/ FREE Mindset Breakthrough Bootcamp: https://lisathelifecoach.kartra.com/page/MindsetBootcampRegistration

The phrase “toxic positivity” refers to the concept that keeping positive, and keeping positive only, is the right way to live your life. It means only focusing on positive things and rejecting anything that may trigger negative emotions. When you deny or avoid unpleasant emotions, you make them bigger. Avoiding negative emotions reinforces this idea: Because you avoid feeling them, you tell yourself that you don’t need to pay attention to them. While you are trapped in this cycle, these emotions become bigger and more significant as they remain unprocessed. But this approach is simply unsustainable. Evolutionarily, we as humans cannot program ourselves to only feel happy and it’s not our job! It’s time to share more of how to take your life back and learn how to respond in a better way! Toxic positivity is not the way of life- love yourself enough to also be real enough with all emotions! Project You starts NOW! Muah

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.08.286955v1?rss=1 Authors: Diaz, J. L., Siththanandan, V., Lu, V., Gonzalez-Nava, N., Pasquina, L., MacDonald, J., Woodworth, M. B., Ozkan, A., Nair, R., He, Z., Sahni, V., Sarnow, P., Palmer, T. D., Macklis, J., Tharin, S. Abstract: The corticospinal tract is unique to mammals and the corpus callosum is unique to placental mammals (eutherians). The emergence of these structures is thought to underpin the evolutionary acquisition of complex motor and cognitive skills. Corticospinal motor neurons (CSMN) and callosal projection neurons (CPN) are the archetypal projection neurons of the corticospinal tract and corpus callosum, respectively. Although a number of conserved transcriptional regulators of CSMN and CPN development have been identified in vertebrates, none are unique to mammals and most are co-expressed across multiple projection neuron subtypes. Here, we discover seventeen CSMN-enriched microRNAs (miRNAs), fifteen of which map to a single genomic cluster that is exclusive to eutherians. One of these, miR-409-3p, promotes CSMN subtype identity in part via repression of LMO4, a key transcriptional regulator of CPN development. In vivo, miR-409-3p is sufficient to convert deep-layer CPN into CSMN. This is the first demonstration of an evolutionarily acquired miRNA in eutherians that refines cortical projection neuron subtype development. Our findings implicate miRNAs in the eutherians increase in neuronal subtype and projection diversity, the anatomic underpinnings of their complex behavior. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.04.283028v1?rss=1 Authors: Gersing, S. K., Wang, Y., Gronbaek-Thygesen, M., Kampmeyer, C., Clausen, L., Andreasson, C., Stein, A., Lindorff-Larsen, K., Hartmann-Petersen, R. Abstract: Canavan disease is a severe progressive neurodegenerative disorder that is characterized by swelling and spongy degeneration of brain white matter. The disease is genetically linked to polymorphisms in the aspartoacylase (ASPA) gene, including the substitution C152W. ASPA C152W is associated with greatly reduced protein levels in cells, yet biophysical experiments suggest a wild-type like thermal stability. Here, we examine the stability and degradation pathway of ASPA C152W. When we expressed ASPA C152W in Saccharomyces cerevisiae, we found a decreased steady state compared to wild-type ASPA as a result of increased proteasomal degradation. However, molecular dynamics simulations of ASPA C152W did not substantially deviate from wild-type ASPA, indicating that the native state is structurally preserved. Instead, we suggest that the C152W substitution prevents ASPA from reaching its stable native conformation, presumably by impacting on de novo folding. Systematic mapping of the protein quality control components acting on misfolded and aggregation-prone species of C152W, revealed that the degradation is highly dependent on the molecular chaperone Hsp70, its co-chaperone Hsp110 as well as several quality control E3 ubiquitin-protein ligases, including Ubr1. In human cells, ASPA C152W displayed increased proteasomal turnover that was similarly dependent on Hsp70 and Hsp110. We propose that Hsp110 is a potential therapeutic target for misfolding ASPA variants that trigger Canavan disease due to excessive degradation. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.24.265207v1?rss=1 Authors: Kinare, V., Iyer, A., Padmanabhan, H., Godbole, G., Khan, T., Khatri, Z., Maheshwari, U., Muralidharan, B., Tole, S. Abstract: Protein cofactor Ldb1 regulates cell fate specification by interacting with LIM-homeodomain (LIM-HD) proteins in a tetrameric complex consisting of an LDB:LDB dimer that bridges two LIM-HD molecules, a mechanism first demonstrated in the Drosophila wing disc. Here, we demonstrate conservation of this interaction in the regulation of mammalian hippocampal development, which is profoundly defective upon loss of either Lhx2 or Ldb1. Electroporation of a chimeric construct that encodes the Lhx2-HD and Ldb1-DD (dimerization domain) in a single transcript cell-autonomously rescues a comprehensive range of hippocampal deficits in the mouse Ldb1 mutant, including the acquisition of field-specific molecular identity and the regulation of the neuron-glia cell fate switch. This demonstrates that the LHX:LDB complex is an evolutionarily conserved molecular regulatory device that controls complex aspects of regional cell identity in the developing brain. Copy rights belong to original authors. Visit the link for more info

How does our evolutionary history shape our current world? What's up with sexy jawlines? Will being quarantined while staring at computer screens all day change how humans look? In this episode Shane talks with returned guest Herman Pontzer, who is a Professor of Evolutionary Anthropology at Duke University. You can learn more about Pontzer's work at https://evolutionaryanthropology.duke.edu/people/herman-pontzer Thank you for watching and being an inquisitive being.

The Argus Pheasant is a lifelong bachelor. He mates with multiple females but has no further contact with his mates or the baby pheasants he sires. By human terms, not much of a feminist. Yet, he stages a chivalrous courtship on moonlit nights on a forest stage he clears with meticulous care. He sings and dances and pecks. He encompasses his 'date' in a cape of intricately-colored four-foot-long feathers. He ends with a bow. Evolutionarily, there's no purpose for the spectacular feathers on the Argus Pheasant - unless you consider they may have evolved to satisfy the sexual preferences of the female Argus. Darwin, while famous for his theory on evolution through battle for the fittest, also promoted a second, less popular theory of evolution through female sexual preference. This theory may also shed light on evolved human traits and behaviors we don't need to survive - like female orgasm and same-sex preferences. GUESTS: Richard Prum - Evolutionary Ornithologist, Professor of Ornithology at Yale and the curator of Ornithology at the Yale Peabody Museum of Natural History. He’s the author of The Evolution of Beauty: How Darwin’s Forgotten Theory of Mate Choice Shapes the Animal World - and Us. Patricia Brennan - Evolutionary Biologist, Behavioral Ecologist and visiting lecturer at Mount Holyoke College. Support the show: http://www.wnpr.org/donateSee omnystudio.com/listener for privacy information.

There's a scientifically proven reason why dangers and fears occupy space in our heads. Evolutionarily speaking, this is how our species has survived. But does this hard wiring serve us as well as it did for our long-ago ancestors?  By understanding the principles of psychology and how Negativity Bias and Learned Helplessness create self-limiting thinking, we can transcend, opening the door to the near limitless world of possibilities beyond. --- Send in a voice message: https://anchor.fm/dointhething/message

Podcast Notes Key Takeaways “10,000 years ago (Neolithic Revolution), we switched over to things that we had never eaten before and those were the grains of grasses and beans” – Steven GundryThe human body didn’t evolve to eat these plants“There’s never been a documentation of an ape eating grass or grains”Many of these plants have high concentrations of lectins; these are proteins formed by a plant’s defense system that kill organisms if ingestedLectins cause eczema, acne, brain fog, and irritable bowelsAvoid eating American plants unless properly prepared.None of us were exposed to American plants until 500 years ago.Evolutionarily speaking that’s like a one night standDr. Gundry’s patients have improved their health simply by taking grains, beans, and nightshades out of their dietseval(ez_write_tag([[728,90],'podcastnotes_org-medrectangle-3','ezslot_0',122,'0','0']));Read the full notes @ podcastnotes.orgOn today's 5-Minute Friday, Lewis revisits one of his most impactful interviews with health expert Dr. Steven Gundry, who has carefully studied what we put into our bodies. Believe it or not, some of the foods we consider healthy might actually be incredibly damaging.For more School of Greatness, visit lewishowes.com/960. And text Lewis at 614-350-3960

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.16.100008v1?rss=1 Authors: Young, B. K., Ramakrishnan, C., Ganjawala, T., Li, Y., Kim, S., Wang, P., Chen, R., Deisseroth, K., Tian, N. Abstract: Neurons in the CNS are distinguished from each other by their morphology, the types of the neurotransmitter they release, their synaptic connections, and their genetic profiles. While attempting to characterize the retinal bipolar cell (BC) input to retinal ganglion cells (RGCs), we discovered a previously undescribed type of interneuron in mice and primates. This interneuron shares some morphological, physiological, and molecular features with traditional BCs, such as having dendrites that ramify in the outer plexiform layer (OPL) and axons that ramify in the inner plexiform layer (IPL) to relay visual signals from photoreceptors to inner retinal neurons. It also shares some features with amacrine cells, particularly Aii amacrine cells, such as their axonal morphology and possibly the release of the inhibitory neurotransmitter glycine, along with the expression of some amacrine cell specific markers. Thus, we unveil an unrecognized type of interneuron, which may play unique roles in vision. Copy rights belong to original authors. Visit the link for more info

Homo sapiens environment of evolutionary adaptedness bathed the infant in rich environmental stimulation, both social and non-social. Because of this, 21st century babies still thrive best in the context of diverse and complex sensory-motor experience, and when loving adults and older children respond to the baby and grow increasingly long and complex social reciprocity chains. https://www.frontiersin.org/articles/10.3389/fnint.2019.00066/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Integrative_Neuroscience&id=483495 (The latest neuroscience proposes the primacy of motor development for optimal developmental outcomes. Motor development is enhanced by experiences of postural variability and sensory-motor stimulation from the beginning of life.) Dr Pamela Douglas and https://public-health.uq.edu.au/profile/1204/peter-hill (Honorary Associate Professor Peter Hill) reflect upon the potential risks of infant sleep training practices, which problematise sensory-motor stimulation, during a time of social isolation. Pam is a GP-researcher and https://education.possumsonline.com/ (founder of the evidence-based Neuroprotective Developmental Care (or 'Possums') programs) www.possumsonline.com. She is also author of https://www.amazon.com.au/Discontented-Little-Baby-Book-ebook/dp/B00M6G1ABO (The discontented little baby book: all you need to know about feeds, sleep, and crying).  Support this podcast

Molecular Biologist Dr. Keith Booher talks about the Horvath epigenetic clock and the why and how behind finding out your biological age. Keith Booher received his PhD from the University of California, Irvine in 2011 where he conducted research in the field of cancer cell metabolism. He then began work at Zymo Research Corporation developing methods and assays for the investigation of epigenetics. Along with colleagues, he contributed to a high impact study evaluating methods for DNA methylation validation in 2016. Keith continues to study epigenetics in his current position as Application Scientist at The myDNAge company or Epimorphy, LLC, in Southern California where his research is focused on healthy aging and longevity. In his free time, you can find Keith either on the dance floor, at the local library, or spending time with his family. "The world population is aging, especially in the West and the industrialized countries of Asia. In fact, the percentage of the population over the age of 65 is expected to more than double by the year 2050. An aging population presents many societal challenges as advanced age is the number one contributor to chronic ailments such as heart disease, cancer, neurological disorders, and more. It is imperative that meaningful and effective anti-aging interventions are identified and deployed in order to ease the transition from a younger to a gradually older population. Epigenetics involves the modification of gene expression without changing the underlying DNA sequence. Importantly, many recent scientific studies demonstrate the connection between epigenetics, especially DNA methylation, and aging. To date, analyzing changing DNA methylation patterns at key genes is the most accurate way to quantify the aging process. Understanding the connection between epigenetics and the aging process allows us to gain deeper insight into the mechanisms that cause aging, with the ultimate hope of devising interventions that will potentially lead to better health and longevity.    Dr. Booher highlights the use cases for this new type of testing and it's used for those individuals or teams wanting to understand what protocols, training regimes, food plans, supplement regimes etc impact their own aging and how you can maybe even turn back the clock ticking on us all.   Get yourself tested and find out your biological age at: https://www.mydnage.com/ Use the code 'LISA15" to get a 15% discount on the cost of the test   Watch Dr. Keith's Ted Talk  https://www.youtube.com/watch?v=PeT1RcwsDMc     We would like to thank our sponsors for this show:   www.vielight.com   Makers of Photobiomodulation devices that stimulate the brains mitocondria, the power houses of your brains energy, through infrared light to optimise your brain function.  To get 10% off your order use the code: TAMATI at www.vielight.com     For more information on Lisa Tamati's programs, books and documentaries please visit www.lisatamati.com    For Lisa's online run training coaching go to https://www.lisatamati.com/page/runningpage/ Join hundreds of athletes from all over the world and all levels smashing their running goals while staying healthy in mind and body.   Lisa's Epigenetics Testing Program https://www.lisatamati.com/page/epigenetics/ Get The User Manual For Your Specific Genes Which foods should you eat, and which ones should you avoid? When, and how often should you be eating? What type of exercise does your body respond best to, and when is it best to exercise? Discover the social interactions that will energize you and uncover your natural gifts and talents. These are just some of the questions you'll uncover the answers to in the Lisa Tamati Epigenetics Testing Program along with many others. There's a good reason why epigenetics is being hailed as the "future of personalized health", as it unlocks the user manual you'll wish you'd been born with!  No more guesswork. The program, developed by an international team of independent doctors, researchers, and technology programmers for over 15 years, uses a powerful epigenetics analysis platform informed by 100% evidenced-based medical research. The platform uses over 500 algorithms and 10,000 data points per user, to analyze body measurement and lifestyle stress data, that can all be captured from the comfort of your own home   For Lisa's Mental Toughness online course visit:  https://www.lisatamati.com/page/mindsetuniversity/ Develop mental strength, emotional resilience, leadership skills and a never quit mentality - Helping you to reach your full potential and break free of those limiting beliefs.    For Lisa's free weekly Podcast "Pushing the Limits" subscribe on iTunes or your favorite podcast app or visit the website  https://www.lisatamati.com/page/podcast/     Transcript of the Podcast:      Speaker 1: (00:01) Welcome to pushing the limits, the show that helps you reach your full potential with your host, Lisa Tamati, brought to you by Lisatamati.com welcome to pushing the limits. Speaker 2: (00:12) Let's see everyone. Thanks for joining me again today. I have a scientist to guest on the show, Dr. Keith Booher. Now, Dr. Keith is a molecular biologist and he works for a company called mydnage.com. Now this is a company that uses Dr. Steve Horvath's epigenetic clock. This tells us our biological age. So we have a very interesting conversation around the difference between your biological age your, your chronological age, and also the method of telling how old you are based on your DNA. So we're looking at DNA methylation as opposed to some of the other processes that look at biological aging from other factors. And we get to into a deep dive about looking at your biological age. Now this is really interesting from a perspective from coaching, from I'm trying to draw a line in the sand to see where you are now. Speaker 2: (01:08) And I can see this having benefits. We are looking at it for our mastermind program where we're thinking about having this as our baseline to start from where we can actually see what your biological age is at one point in time when you start. And then using that as we go through our program to see how you come out at the other end. And hopefully you would have lost a number of years off your life as far as your biological ages going. So this was a very interesting deep dive into this topic. So I hope you enjoy the show. And just before we go over to Dr Keith just like to remind you that I have my book relentless coming out in just a couple of weeks time or four weeks time and it's on the 11th of March and launches, it's available for preorder now you can jump on my website, hit the shop button and preorder it. Speaker 2: (01:57) And at moment you'll get access to my mindset Academy mindsetu for free. If you join or buy the book in the preorder stage, you'll also get a discount. It'll normally be retailing for $35. You'll get it for $29 plus you get access to mindset, you a value of $275. So really good idea to go on and jump and now and get it. And that helps me get the book rolling, get it out into the world. It's been a two year long process. So really excited to see that baby launch. As always, reach out to me if you've got any questions on this episode or on any of the other episodes that we've recorded. And I really appreciate your help with ratings and reviews on iTunes that really helps the show get exposure and of course sharing it with your friends and family if you got value out of it. So thanks and now over to Dr. Keith Booher from mydnage.com. Speaker 3: (02:49) Well, hello everyone. Lisa Tamati speaking and here I'm pushing the limits. I thank you once again for joining me today. I have a wonderful guest, Dr. Keith Booher who is a biochemist. Is that correct case? Speaker 4: (03:02) Yes, that's correctly. So thank you for having me. Speaker 3: (03:04) Yeah, it's wonderful to have you. So Keith is going to talk to us today about the biological clock. He works for a company called mydnage which does testing of the biological age as opposed to your chronological age. And this is a very interesting area we in our company through it continued existing without athletes and clients. So this is something that I'm very interested in finding out more about in cases coined the agreed to come on the show and talk to us about it. So. Okay. Can you give us a little bit of background about who you are and where you come from and, and the work that you're doing? Speaker 4: (03:46) Yes, certainly. So, so my name is Keith Booher. I'm a scientist. I worked for the company epi Morphe that offers the mydnage test. This isn't a epigenetic, a base test to quantify aging or biological age. And my background I got a PhD in biological chemistry. I'm from the university of California, Irvine here in Southern California right now. They've worked and where the company's headquartered. I then joined a research companies. I'm a research, Oh, also in California when I started doing epigenetics research in an industrial setting and then transitioned to a, working with the epi Murphy and offering the mydnage test. Speaker 3: (04:28) Wonderful. So can you tell us a little bit, well, for the listener, what is epigenetics and the area of study of epigenetics and what is on those a biological clock? Speaker 4: (04:39) Yeah, so I think, so the scientific, no definition of epi genetics, so it's a biological term. So simply refers to any changes in gene expression that occur without altering the primary DNA sequence. So what that sort of means in lay context is any, any instance where our genetics interacts with the environment. So sort of nature versus nurture a concept. So what epigenetics then does at the molecular level is to help control gene expression or to help turn genes on or off, or how strongly genes are expressed in the cell. I think an analogy that I've heard before, which is it's not perfect, but I think gives you the idea would be that our genes, our genetics, it'd be the hardware with which we operate. And epigenetics would be the software or instructions that tells that hardware what to do. Speaker 3: (05:33) Wow. Okay. So, so in other words, our environment, what we eat they, the, the, the, the toxins in our environment. Eric's the size, whether we do any or not, all of these things will have an effect on how our genes express themselves. So we've gone as sort of DNA code, which we can't really change. Yeah. What genes are turned on and off can be affected by environment. That, correct. Speaker 4: (05:58) Yeah, that's absolutely correct. So there's lots of studies looking at how epigenetics change in response to environment. So this, you know, in the past decade, decade and a half, there's been a lot of progress made by the scientific community. So we know that you know, people that go on a controlled exercise regimen you know, when they start versus a, when they stop after six months and compared to control group. So there are genetic changes that, that occur in a skeletal muscle. So we know that people have also looked at adipose or the fat tissue and also seeing epigenetic changes in response to certain exercise programs. We also know that smokers have a different epigenetic, I'm marks highly correlative with smoking. Mmm. That these epigenetic marks behind people in certain occupations where they're exposed to a lot of environmental pollutants such as coal miners, a certain factory workers also have pronounced epigenetic changes compared to those that aren't occupied in such fields. Speaker 4: (07:04) I think another, sorry, maybe another example just to really, it would be easy to understand is if you look at twins. So twins are genetically identical individuals. However, through the course of their lives. So we know what, you know, when they're young, we can take it classmates in grade school with some twins. I mean, you couldn't tell them apart. Right. But if we think of older twins, you know, throw the course of their lives, you know, they maybe move to different places there obviously the families that they no start you know, they have different sort of traditions, different diets perhaps they like to eat, you know, brought in from their own partners and all these different influences impact their epigenetics. Right? So these still genetically identical individuals but the epigenetics change based on their environment and their lifestyle and when they're older, they actually don't resemble each other as much as they did when they were. Yeah, sure. Speaker 3: (07:59) That's really good example of, of, of the, the power of epigenetics isn't it? I saw a photo of a pair of twins that I think were on the Oprah Winfrey show years ago. And two ladies, one very, very overweight one, one not and the identical twins. It's a really, it's an easy way to understand how much your environment fix your epigenetics of fakes your and how you end up. So in other words, we can't just blame mum and dad and our ancestors for what we've got. We have some responsibility for how we tune out. Is that right? Speaker 4: (08:37) Yeah, that's right. And I think it's it's actually allows us to take control and you know, kind of dictate where we want to be so we can, we're not destined for some, you know, fate just based on our, our genetics. We, we can actually influence what those genetics do. Speaker 3: (08:55) Yeah. So is this so I'm, I, I've read a lot of Dr. Bruce Lipton's work and books. And you know, I have found this whole area really, really fascinating and it's pretty new, isn't it? In the scientific world, like we're talking what the last 30, 40 years or Mmm. Oh, that, that scientists have really understood that the, it's not just your DNA that makes you who you are. Is it pretty new field? Speaker 4: (09:22) Yes and no. So I think we're all familiar with the Charles Darwin and in his theories on evolution. He's one of the preeminent scientists, the modern world. Actually before Darwin, there's a French, a scientist and philosopher, a Lamarck who, you know, he actually predicted that the, you know, wow. What are our, our parents or the mother and father the type of lifestyle they live. Okay. Their environment will impact. Mmm. The children. So it's actually a heritable trait passed on just based on, so he said that if you were, if your parents, did you follow with a blacksmith, you know, all the hard work that makes them strong will then be passed onto to his children. Mmm. And like a giraffe that you know, needs to a stretch to reach the the leaves from on the tallest branches of the tree will, you'll get a longer neck and then that'll be passed down for the next generation. Speaker 4: (10:17) And this is, this is a way that, okay. Drafts have evolved. Mmm. Once Darwin's theories came out and were tested you know, Mendell then proved how genes, I kind of demonstrated how James can, can, can behave. A lot of the marks, theories were just you know, kind of put in the, the dustbin of history and he was sort of left off, you know, these were, these were sort of thought as ridiculous principles, but a sure enough, as you, as you just mentioned, Lisa, in the past several decades, actually, the Mark's original theories have been proven to be a, have a lot of Yeah. He was before his time. And we know this to be true. I mean, the, the biology is clear that and then we're learning more about it all the time. And even in I think 2014 as these studies were coming out more and more showing the power epigenetics you know, a portrait of what Mark was on the cover of nature magazine and they kind of featured and, you know, paid homage to his, his original theories. Speaker 3: (11:15) Wow. What a shame. He wasn't around to say that a bit. That would have been the kinds of a lot of things. So in other words, so when we're talking evolution here or intergenerational . I, I read some way that, for example, when a mother smokes and the baby's in the, in the womb, that that can affect the baby's DNA and then it can affect also who children's DNA. Is that correct? The intergenerational nature, or is that a Zeta? It's not, is it epigenetics or is that more genetic changes? Speaker 4: (11:54) Oh, well, so any genetic change that's altered in a, what we call the germline. Oh, you know, the the male gametes are the chemo sites. That's certainly genetically heritable changes that occur in our you know, the scan for example, know if we know examples that give rise to cancer or something don't. So those wouldn't be heritable. Right. So like if something like skin cancer epigenetics, then, so, so for it to be heritable, it has to occur in the germline so that that would be the same for genetics or, right. Yeah. So we, so certainly genetic change is hard. I mean, that's, that's very clear. Epigenetic is it seems to also be true. There's lots of circumstantial evidence. It's very difficult to do these studies in humans for obvious reasons. Hmm. Other studies and other types of model organisms, the biologists often used to study different phenomenon indicates that indeed epigenetic inheritance inheritance is, is a observed phenomenon. I think it's very strong evidence in plants. I mean, these, these, these traits are, I mean, they persist for it. Dozens of generations in mammals, you know, maybe more temporal. So two to three or even four generations, but not not, not that stable, but it appears that they are here. Speaker 3: (13:16) Wow. Okay. So so we can affect our whole, yeah, the intergenerational aspect of it is quite interesting, but if we, if we just back up a little bit now and go into the dr Steve Horvath's work in the Horvath clock and I believe that is the basis of the work that has his work is the basis of, of the testing that you do. Can you explain what dr Horvath discovered and what that means for biological age and what, you know, how, how, how we can use it perhaps? Speaker 4: (13:50) Yeah. So this biological aging or epigenetic aging clock. So dr Horvath I think is the worldwide leader in this research. So he originally published a study in 2013. There was actually another study that came out actually a little before his that did something very similar. So I should mention too, it, he's, dr Horvath is a professor at UCLA. Oh. Petitioning biologists, computational biologists. So what both these research groups did, so her about that UCLA and then another group led by Hannah at a UC San Diego. So both in Southern California. So what they did was they looked at the epigenetic, a data for thousands of individuals and the applied some complex statistical mathematical algorithms. And what they found was that there were patterns of a change, epigenetic change that occurs with age. And so by of tapping into these different patterns, they could develop a model that would predict [inaudible] predict age based on epigenetic information. So, so that's where the clock came from. So basically, depending on what your epi genetics show, you can then assign a biological age Speaker 3: (15:05) Without any information. On the individual yourself. If you can take just a drop of blood, you can actually say with, with pretty, hi Jackness call it 98, the single thing. How well would that individual is based on the work from dr Hova? So most people fall into this, this Linea Patton that would say, well, this person has these markers on the DNA before that person is the Savage, is that how it works? Speaker 4: (15:42) That's correct. That's correct. So I think there's one. So it's not, it's not just that you want to predict an age, but it's actually a signing up biological age. Yes. So I think that's a key kind of thing to keep in mind. So no, we talked about the twins earlier, you know, a few moments ago and we can see that some based on, you know, one was overweight and the other was more fit based on their lifestyle choices. So the did the choices that we make in our lives. So whether we exercise or eat a healthy diet other things, Mmm. Influencer epigenetics, which can turn in turn influence our aging. So we can actually have and accelerated aging compared to an average person or actually a slower rate of aging compared to someone else. So the Horvath clock measures that, that biology based on the epigenetics. So, you know, you may be 10 years younger biologically than your chronological age, which would be indicative of, you know, good health or good cause I've stopped choices you've made. Speaker 3: (16:45) Do you see big swings in the like, you know, 10 years or is it mostly that most people are in the, you know, within a year or two off via at their actual chronological age. Speaker 4: (16:56) So most people will be within a year or two. That's, that's Mmm, that's what you know, Horvath and others have shown. And that's what we see in our data. However you do see outliers. And I think every time we see a case where someone is okay, we do see 10 or, or greater years difference. Wow. It, it seems to be associated with, I mean, it almost in every case, there's some reason why. So some known this person may be suffering from a genetic disease or I think one thing common in, and you know, people we've looked at is, Oh, they've been treated with chemotherapy. So these are very powerful drugs that you know, obviously to, to treat cancer, but I have very strong side effects. I mean, this is very well known. These, you know, some are just not tolerated well at all. And we know these, these type of people have actually accelerated aging, very rapid aging compared to an average person. Mmm. Speaker 3: (17:53) Do you see the other way like, people who have lived a, you know, extremely good, healthy lifestyle with good food, good exercise not too much stress you know, 18 or more years younger than there a chronological edge. Speaker 4: (18:08) So I don't think just for lifestyle choices, I don't think we've seen a huge effect in that regard. But there we have seen some strong effect. I think for certain people are doing certain targeted interventions, it's a little more and just trying to eat more vegetables or run a little further. These are taking drugs. So I think Metformin Speaker 3: (18:32) hmmm Speaker 4: (18:33) There's one that's looked at very seriously for some of these anti-aging effects and we do see a pretty consistent, strong effect towards a slower aging. Yeah. Speaker 3: (18:44) [Inaudible] Is a, is an interesting one because it doesn't let up think though negatively the, the mitochondria. And, but, but it was a little bit confusing when I looked into just some surface level research on Metformin thinking, gosh, this sounds interesting. I want to have that. It, it produces more longevity, but it can damage the mitochondria. How would that work? Because your mitochondria, your rap part of this whole metabolic pertussis, I mean, it's probably too deeper questions to ask you, you know, but do you know why? Speaker 4: (19:20) Well, that's, that's a very good question, huh? The short answer is no one knows why. So, so yeah, there's sort of a antagonistic effects on or seemingly that would, that would associated with adverse health outcomes. But the data showed, we know it has been prescribed for type two diabetics years and has very good outcomes. And it seems to be off target prescribed for other melodies as well. You know, that the side effects are, are small. I mean, that's just based on you know, lots of people taking the drug. It seems that small side effects and clearly the benefits in most cases outweigh the whatever side effects may occur. Mmm. As to the reason why, I mean, it may be that the positive affects to regulate glucose metabolism, insulin, Speaker 3: (20:16) Yup. Speaker 4: (20:18) Maybe more important than the damage it causes or we have you know, just backup systems to deal with mitochondrial damage or stress that we don't have as robust. I mean, just as you know, living human beings that we don't have for when our glucose metabolism goes awry. Speaker 3: (20:35) So you know, that would be especially the case for, you know, people with diabetes or prediabetes. It has the same effect then on the healthy, you know the healthy person who doesn't have insulin resistance or any glucose Speaker 4: (20:49) Problems. So, yeah. So we get this, I get this question a lot. I would be very careful about just taking any drugs, you know, getting home from certain websites for example, I would, I would consult a physician for that. Yeah. Yeah. Cause I know your listeners are probably very interested on what types of things they can do to, to help them. Speaker 3: (21:15) Nobody don't go out there and do anything solid, not advocating this. We definitely won't. But, but it's interesting to look at the data. I know that there was a study done just a couple of years ago, I think by dr Horvath where they were able to reverse the, the epigenetics Speaker 4: (21:33) Clock Speaker 3: (21:34) In a small clinical study by giving people growth hormone and to diabetic medications, I believe. One. Mmm. And they took two and a half years off the year. Speaker 4: (21:49) Mmm. Speaker 3: (21:49) I'll say biological Speaker 4: (21:51) Age. Speaker 3: (21:53) That's, that's pretty exciting to actually be able to reverse. I mean, I know this was a small clinical trial and, and certainly not a big one. And obviously it's a very difficult area to do big blocks studies end, but a w would suggest that we're going to be able to in future reverse the aging process, which is super exciting rather than just slowing it down. Speaker 4: (22:17) Yeah. So this was the study you mentioned was a, that was a big one. So there's a lot of I don't know a lot, but there's a, there's a decent amount of studies you know, the Horvath and others have been involved in showing on ways to slow the rate of aging. But I was at a, a, a conference actually I gave a presentation along with the, dr Horvath was a keynote speaker and there was another, a surgeon Jim Watson. No. And Jim Watson said, you know, we think that we will be able to reverse actually reverse the clock. And Horvath was, this was January, 2018. He was pretty, he pushed back pretty hard on that idea. He said, you know, there's, there's nothing we found that can actually reverse aging clock. I, there's nothing in the data that shows that, you know, Jim Watson, he's a, he's a prominent Sergeant, you know, he works with patients and you know, from his medical person, he's like, well, I respectfully disagree. Yeah. And if you look at the authors on the paper, you mentioned Steve Horvath, but actually Jim Watson is, I think he's a senior author on that. Mmm. They ended up collaborating after this, you know, and [inaudible] looking into ideas from the medical side and then from, you know, dr horvath, you know, using this, these, these epigenetic aging clocks. And sure enough just as you mentioned, the study showed it was small, but it showed clearly that the aging was reversed to these individuals Speaker 3: (23:39) In a, in a very short space of time too, which is exciting to think what would happen if these interventions were, you know, extrapolated over a longer period of time. Mmm. Speaker 4: (23:52) Yeah. That's, that's right. I, you know, if you look at the, the intervention in that case, it was a drug cocktail. It was a two, two hormones, DTA I think human growth Speaker 3: (24:05) Yeah. Speaker 4: (24:06) And then I met foreman again was a drug they use to kind of help regulate some of the hormonal side effects of those drugs. And it was this three drug cocktail. Mmm. The the original goal of that study was to help reverse some of the immune decline. It had been well documented. We know our immune system starts to decline and as we grow older and the famous of course this organ that it functions in immune, you know, healthy immune function tends to get weaker and shrink. And so that's what the, the study was originally designed to just boost thymus function in the immune system. And okay. The authors showed clearly with, yeah, with, with clinical measurements, famous enemy and functions were restored and it was then shown, that's when Horvath came in and looked at the the epigenetics to show that actually reversed in these people who had responded well to the treatment. So Speaker 3: (25:04) Yeah, that's a short time frame as you mentioned. Yeah. Yeah. Very exciting. There's hope for us who are aging that we bought. So hurry up. You guys get started in so with the, the Magii and H test which people, you know, the public can go and get the SKUs. So if you wanting to actually, after listening to this episode want to go and just what your biological ages, I'll give you the address. It's just my, my DNA h.com. So DNA G a.com and you can order a test the and have the stun, which I, I'm, I'm finding fascinating from a coaching perspective and from an athlete's perspective to be able to draw a line in the sand and say, well, this is where we started from. And then we, you know, instigate L a epigenetic program for example, and our training regimes and nutrition and so on. Speaker 3: (26:00) And then perhaps in six to 12 months time retest to see what the I need a fake was. So I'm, I'm excited to be able to hopefully incorporate this into some of our, of our programs. And one of the reasons I reached out you today when we, let me go to the, look at the the testing that you do. So you're looking at the DNA methylation, is that right? Mmm. Can you explain what the United w what exactly that you're looking there with the, when you're looking at the methylation marks on DNA? Speaker 4: (26:36) Yeah, yeah, that's right. So we're looking at DNA methylation. So know anyone who wants to use our test, I might, do you need Speaker 3: (26:44) To test? Speaker 4: (26:45) We would send them a kit. Mmm. We would it comes with you know, slow land so we can take a blood drop. Mmm. That's put into a, you know, a special preservation stage or buffer solution. Speaker 3: (26:57) [Inaudible] Speaker 4: (26:57) Your preserve the integrity of the sample and then it can just be mailed back at room temperature. So it doesn't need to be frozen or cold or anything. I think also send a urine sample as well. So it's, it's, it's up to the it's each individual if they feel comfortable with, Mmm. That's sent back to us from the blood or urine sample. We will extract the DNA and then perform some fancy chemistry to quantify DNA methylation levels at a panel of genes that are known to be highly associated or highly informative of aging. Speaker 3: (27:32) Huh. Speaker 4: (27:33) Based on those values, we can then plug it into a mathematical model to predict the biological age. And again, this is, this is based off of a, you know, Horvath and others of the based on original publications. We sort of make it a economic one available too. And Speaker 3: (27:54) Sorry, Carry on. Speaker 4: (27:58) So we can make that that technology, which would otherwise not be accessible to non scientists. The general public, we can make it accessible to them. So they can, they can get their own biological age assessment. Speaker 3: (28:10) Yeah. It's really, really exciting. So, so you're looking at around 2000 different James. Mmm how do you, how do you express it? He was signs on there. They had assigned basically there was damage here. So you're looking at damage, Marcus. Speaker 4: (28:30) It's not, it's not famous markers per se. So specifically it's, it's DNA methylation. So a methyl group is a, you know, if you think from your organic chemistry, this is the most the oxidized form of carbon. A ch three is added to DNA and basis known as cytosines any basis on the cytosines. And when it's added biologically, what's going on at the molecular level is it's influencing gene expression. So helping genes turn on or off, on or off. Mmm. And these levels change over the course of our lives and it's this change that can then be related to, to, to the Speaker 3: (29:12) Marcus. Okay. I get that. Yeah. So does it take into consideration things like inflammation or cardiovascular health or kidney and liver function or metabolic metabolic state as well? Or is that readable from the DNA? Speaker 4: (29:32) Not with, not with the mighty age test. So if there's something specific like that, again, I'm in consultation with a physician. If you're worried about your Speaker 5: (29:41) Kidney health, metabolic health, Mmm. Then, right. You know, there's more specific tests to directly look at. Right, right. I think as a pan health indicator it gives you some information. Right. Cause I know that there is you know, other companies that do biological age tests that are based not on the Horvath clock, but on, I'm looking at these are the tops of biomarkers, like your inflammation, inflammation, they've always been your, your cardiovascular health. And I was trying to understand what is the difference in the, in the approach, you know, in the approaches and which one is, Mmm. Well going to give us some more exact calculation if you like. Do you know of the other ones and the difference between, well I mean, so there's, there's a lot, you know, people have been using like in a doctor's office, just a grip, the grip test, your vape. Speaker 5: (30:39) How will you walk? Yeah. The way you walk. But you know, there's a really broad era for those, for people you know, between the ages of teen until some point in your, your older years. Mmm. It's just not very, not very good. It's very precise, very precise. There's other molecular tests. Even if you look at DNA methylation or epigenetic tests, they may focus on a single gene or just a few genes having a, a more focused, you lose a lot of robustness so they can be more susceptible to small changes or small, Mmm. Environmental insults that may actually not have a big impact. So by incorporating thousands of sites into the tests, which, or my teenage test does, it's more robust to small changes. So overall picture. Yeah, that would be it. You know, cause when I heard about things like grip strength and stuff, I was like, well, if I got into the gym a lot, obviously I'm going to have a lot more grip strength. Speaker 5: (31:39) It doesn't necessarily, I'm biologically younger. Right, right. Yeah. Basically you say, I have a normal or we're better than average. Right. Or it's not good. Right? I mean that's, you get kind of a yes or no kind of a yes, yes. But it's not, it's difficult to say, you know, you know, you're looking at the also your body type, you know, like, and with your, you're a muscular person or you're a someone who is more of a flexible person, you know, there's, there's just too much. Okay. Wavering in the air. I mean things like inflammation markers of course. Can you look at the state of your health but perhaps notch the actual, you know, whether it's having damage, you mean you can have inflammation markers because you've got a cold as well, which would be skew the data satisfied. and a bad week. Speaker 5: (32:35) Yeah. And this wouldn't happen with the, with us taste. So how w I know you've done a Ted talk that I listened to that was very interesting thing and wants to look that up. We can put that in the show notes as well. We've got an aging world population and we have huge problems all around the world without, but their health care system. I think we probably can all agree with that. We're heading into times where chronic disease is going to be costing economically, governments in, in, in, you know, a lot of suffering around the world and a lot of resources. Mmm. So increasing health span is, is a very important piece of being able to lower the costs involved with chronic disease. Would you see that as being one of the areas where this this theory or science is really, really key and an important from a, from an economic standpoint as well as from the personal suffering standpoint? Speaker 5: (33:39) Right. Yeah, absolutely. Yeah. Right, right. I think the potential to benefit society is really there's a, there's a lot a DNA aging test, epigenetic aging tests can, can provide. So it is clearly the best tool, two, assess, aging accurate and precise way. Mmm. And so by using this tool, I mean, whether it's, you know, our company and our researchers doing, you know, in their own labs are their own ways. Mmm. Those interventions which will have the greatest benefit can be more rapidly identified and no, very okay track to be very cheap. I'm an actress. So this, I think this is, you know, beyond just individual testing, which I think is important. And, you know, very interesting people empower themselves by getting some information here, but broader for the broader impact it can have on society. It can be really profound. Yeah. And I know you've, you've done a little bit of work with you mentioned the, in your, in your talk you know, looking at things like sporting H, you know, like how if kids are really in the right age group or people who don't have documents working out how old they are. Speaker 5: (34:56) When they coming into countries perhaps as, as refugees without, without any paperwork and things like that. There's a, there's a, there's a whole lot of areas that this could be utilized and couldn't it. Yeah, absolutely. Yeah. So the the youth age testing I think that's, there's sort of a, the, the, the consequences are not as, as grave as like, you know, that aging population in Europe, you know, to some extent, North America and Asia. But but I, it just goes to show the potential applications for something like that. And I actually just learned that, you know, I did some work with [inaudible] law enforcement in Germany a couple of years ago for some for forensics application of using this aging. You can sort of the gauge person of interest in different law enforcement investigations. And in part thanks that work actually I just found out that lie in Germany changed December Oh about 2019. Speaker 5: (36:01) Sort of allow this scientific approach, you too well know wow. To work out someone's is being adopted in a lot of different areas. And I mean, Oh yeah. And, and for me I think in working in the, in the health as a health professional and, and training people and so on, it's just going to give us another, I'm wiping the Nantucket toolkit to get people motivated and moving and having a benchmark is really important I think for us to, well, this is where we started from and hopefully through different health interventions, we can see other results. Is there any way that we can, is there any of those things that are quantified, like what, what people are, you know, that are doing your tests perhaps and then doing different interventions, obviously not as a clinical study, but are you gathering any of the data of the interventions that people are undertaking to change the biological age? Speaker 5: (37:01) Let's see. What has it effect? So I mean, we have to be sort of careful about this, right? So that, I mean, the personal information of ours customers is yes. Obviously I can only do so much, right? I mean we're not, we're not trying to but so what I can say, we work with clinics, certain clinics doctors. So the doctors are incorporating this test into part of their medical practice and whether they're advising certain, you know, dietary interventions or different exercise programs or they can use this for their medical practically, I mentioned Metformin earlier. We are working with the group by testing this. So that's something that we, yeah, we can say has had a, yeah, a two. The rate of aging in these, in the samples, the subjects that we've examined. Mmm, yeah. Mmm. Yeah. Yeah. So that's got an interesting future too. I mean, what, what are you think, so are there any interventions which have been proven besides a Metformin and growth hormone? Mmm. To actually slow down the aging or to pervasive stop the aging process? Mmm, well that have been proven to be beneficial as it, you know, like lifestyle interventions. So yes, yes, there are. So, but I, I needed qualify that. So this has been clearly shown to occur in laboratory animals, so model research organisms and a lot of these, Speaker 4: (38:34) These pathways a Speaker 4: (38:35) Evolutionarily shared all the way from, you know, simple East to or complex organisms like fruit flies and more recently into mammals like mice lab, mice rats or even nonhuman primates. So there's clearly potential. Mmm. You know some of these interventions are related to altering metabolic pathways, insulin response. Mmm. Mmm. I think one that's gained a lot of interest in you know, the broader news media is this compound resveratrol. Yes. Resveratrol found in a grapes in higher concentrations, in certain nuts. I'm certain it's been shown to activate certain pathways related to protecting our DNA or protecting our genes and genomes and also influencing that metabolism in certain ways. So in laboratory animals, there's clear evidence to show that aging can be slow to reverse. In humans it's not as clear. So again, it's more difficult to do these types of studies. Speaker 4: (39:39) Okay. Ethical and logistical reasons. Yeah. But the Metformin is a hot candidate drug especially because it is well tolerated. So, so this may be something that can be easily prescribed. And individuals we mentioned the study that came out last last fall where the the growth hormone and Metformin combination reverse the aging in this was in a small court of men from the ages of 52 late sixties, I think. Years of age. Mmm. In terms of those are for reversing the aging clock. There's also evidence showing that the clock can be slowed from simple lifestyle changes. So if you think about diet, so it appears that, you know eating more plants plant based foods, so fruits and vegetables. So right carotinoids levels in the blood. You know, indicators of the. Speaker 4: (40:37) Okay. Metabolism are associated with slower rates of aging. Interestingly, a fish, actually, those who consume more fish, it seems to have the greatest impact on a slowing the rate of aging. Well, okay. That's interesting, huh? Yeah. Even greater than the vegetarian diets. That's what the data indicates at this time, at least. Right. Also you know, we can look at things that accelerate the aging clock. Mmm. So certain corn oil certain insulin levels a triglyceride levels you know, elevated or, or, or levels that are out of whack or associated with an accelerated aging. So these are indicators of a poor diet. Yup. I think one that's a, everyone's sort of interested to hear or happy to hear is that actually moderate alcohol consumption. It's associated with a slower Speaker 3: (41:34) Rate of eating. So, so we have an all glass of red wine with berry in it, Speaker 4: (41:40) I think. I think so. Yeah. Yeah. But this has been a also shown to have beneficial effects on heart health. So it's interesting to see that the studies our agreement, you know, coming back, coming at it from different angles, but, you know, finding beneficial health, mental health. Speaker 3: (41:55) So the, the things that we sort of intuitively know that exercise lots of fruit and veggies and you know, that type of thing. It can definitely slow down the aging clock. It's an exercise aspect of it as Sierra, any sort of data or omit, it's how much and what types of exercise or anything like that. Speaker 4: (42:22) So not that I'm aware of. So not that I'm aware of. But that's, but that's interesting. What you say is, you know, people hear this and they say, okay, great, eat more vegetables. You know, I already knew that. Right. But it's interesting the study, but I think you can see, right. So, okay, yes, vegetables are associated with slow rates of aging. So increase that. So it gives, we can show that in the data, but but what's really interesting about the clock of the state, but if you want, if there was one thing you could pick to slow your rate of aging, actually it's fish, right? So it's, it's a it kinda shows you you know, we can kind of rank these. So what's the most important thing? So, you know, vegetables are important, but actually according to the data fishes is even more important. Mmm. And you knew, and also people that die. While I've been doing vegetables, I've been actively trying to do better in, and so I've already incorporated that, but, well, what else is there that that might be, it might be missing. Oh, so a olive oil seems to be also beneficial. A dietary component. It can be incorporated absolute rate of aging. So, so what the clock does is it's able to quantify these and really pinpoint with some precision what, Speaker 3: (43:33) Yeah, yeah. Rather than just one out a feeling as and what we've, you know, at the top, some studies have seen what about ketones and the key she turned on us. Any, any data there on MCT oils or ketone esters or anything like that? Speaker 4: (43:52) Again, I'm not familiar with those studies. We haven't conducted any and we're not working with anyone specifically looking at this sort of thing that I'm aware of some. Again, you know, a lot of institutes and clinics are incorporating different things. We don't necessarily know what they're doing. I mean, it could be very well be that, you know, some of these changes are being prescribed or administered in certain way. I simply don't know the answer to that. Speaker 3: (44:16) Yeah, yeah, yeah. No, fair enough. So this is, you know, to actually get the data to get some concrete data is actually really, really helpful. And strengthening the arguments for reaching the goals and cutting out the, the donuts and the, the the biscuits in the sugar and so on. And, and the more data we have behind that, the beta what I had dr Andrew go Andrews on, on the podcast. We all would go, I'm looking at telling me and like something and NTA aging. Is there any sort of crossover between those sort of areas, like in the anti aging sciences in do you look at it telling me length is or anything like that in these biological tests or are they completely different area of science? Speaker 4: (45:11) It is different. It is different. So Tila mirrors have been I think before Horvath and Hanham's studies a few years ago came out showing the power of epigenetic aging assessments tumors were probably the most popular, well, I color test to look at this since then. You know, clearly that these DNA methylation clocks are by far the most accurate, most precise and robust to measure biological aging. Horvath and others tried to kind of assess how this interaction between Tealium or Lang and you know, epigenetic change and they found that they're not measuring the same thing. So they in the biology is they're looking at different things. And you know, I, I think for, you know, telomeres, you know, I just, in my opinion, I, I think they've been Sur surpassed by the power of the, you know, yeah. Speaker 4: (46:07) Inherent robustness of looking at epigenetics to assess aging. I think, you know, concrete example of this is so the telomere length, so the longer the telomeres, sort of the slower aging or more youthful, that's, that's the basic idea. And as those shrink, it indicates increased age or advanced age. That's, that's the basic idea. We find that this, you know, completely breaks down. When you look at something like cancer where a hallmark is the ability to increase the length of telomeres to kind of okay. You know, maintain the integrity of cancer cells or tumor size. And if you knew, if you look at it from that perspective, they would look biologically young. If you look at the same type. Okay. Tissue cancer tissue according to the epigenetic clock. I mean, these show very accelerated aging. So it's, it's clear indication of it for health. The telomere tests wouldn't be able to show that at all. You were so good. Sorry. Okay. Speaker 3: (46:59) Thats Really you know, emerging area of science that that's, I'm going to be interesting in the next few years to watch. Mmm. Keith, thank you so much for your time today. Is it, I, I think we've, we've, we've covered quite a lot of ground. Do you think there's anything we've missed out that, that people should hear about? In regards to doing, you know, like doing mydnage test can you actually, because we're sitting in New Zealand and obviously a lot of my lessons are in Zealand and Australia. Can you do the test from that far away when you're going to be seeding it in the post? Speaker 4: (47:33) Yes. So the test, so I think we're just trying to get the but just logistics, business-wise, just the paperwork in order too. We've gotten a lot of demand in Australia, New Zealand, you know, it should be a broadly. Yeah. Currently we're only offering and North America, Mmm. In Europe. Mmm. Canada, U S and . But we're trying to get to a New Zealand, Austria. That should be soon. So any listeners in New Zealand or thereabouts, that should be available very soon. Technically there's no issue. So the once the kids arrive the blood or urine sample can be mixed with the preservative solution. This is preservation. Yeah. Shipped back to our labs in California at room temperature with no problems. Speaker 3: (48:22) Nice. So we should be through that. Still already the tastes, even though you haven't got the laboratories and stuff down here, we came can already, you know, through that and seen it. But look, thank you so much for your time today. I think this is a really interesting area of science. And I'm encouraged people to think about doing these tastes because, you know, I will give you a line in the same tree to motivate you. I think a lot of 'em, you know motivation is a big key to being successful in your, in demons to be better and stronger and be there and plaster and normalize going to good things and tuning the, we're slowing down the clock with tuning back even. So having tastes like this that are available to the public, the weekly is exciting. You know, I think it gives us another thing that we can do that we can then use to help better our lives, you know, as we, as we move forward. Speaker 4: (49:20) Yeah. That's the mission of you know, making this test available to the broader, the broader public, Speaker 3: (49:25) The more things that are available direct to the public, the there or my opinion, it's not dangerous and you know, but being a bit of a biohacker, obviously I have a bit of a, a boss towards having your own power and making your own decisions. But I think this one is a, you know, it's a no brainer. It costs so obviously, but apart from that, if you you want to try this out I'll have the links in the show notes and case thank you so much for your time today. I wish you well with all your studies and with loved side contact and yeah, very, very interesting conversation today. Speaker 4: (50:03) Oh my pleasure. Lisa. It was great to, to speak with you. Thank you very much. Speaker 2: (50:07) If your brain is not functioning at its best in checkout, what the team at vielight.com Do now being like producers, photo biomodulation devices, your brain function, the pin's largely on the health of the energy sources of the brain cells. In other words, the mitochondria and research has shown that your brain with near infrared light revitalizes mitochondria. I use these devices daily for both my own optimal brain function and also for other age-related decline issues and also for my mom's brain rehabilitation after her aneurism and stroke. So check out what the team do vielight.com. That's V I E L I G H T .com. And use the code "TAMATI" and checkout to get 10% of any of their devices. Speaker 1: (50:58) That's it this week for pushing the limits. Be sure to write, review, and share with your friends and head over and visit Lisa and her team at Lisatamati.com.

When you’re a first time mom, it can be extremely isolating, daunting, and overwhelming. There are times when you feel so alone because you don’t have the ability to socialize, connect, and network with women and friends like you once did. Evolutionarily speaking, we all need a village. And for me, that’s HeyMama. I live and work from my home in NJ and as you know I have twins and a baby under 3. I am juggling a ton going from digital marketing clients to podcast recordings to family life and found it so challenging to meet new people and prospect since I’m not going to weekly night time events anymore. I was introduced to HeyMama shortly after I had my third by my friend Michelle Ranavat, founder Ranavat Botanics, who lives in CA and then my friend Patrice Poltzer who is also in New York whom I know through BNI (I’m the president of the Activate 58 Chapter in NY) told me about the same week so I applied and was accepted and it’s been just the community I was seeking to be a part of both online and offline. Meet My Guest: WEBSITE: HeyMama.co INSTAGRAM: @heymamaco FACEBOOK: /heymamaco Show Notes: 00:52 - Introduction 03:20 - Backgrounds 05:00 - Creating an opportunity 07:46 - Pregnancy and maternity leave 13:00 - Family friends 19:00 - Membership model 23:00 - Helping women out 30:00 - 'Global domination' 31:00 - Online community and offline community (events) 46:00 - Examples of great leaders 49:00 - Work should be something you love instead of something you have to do 49:30 - 'Mom Sense' moments 56:00 - Quote of the day 1:00:00: Mom Haul Mom Haul: WOOSHBEAUTY: WooshBeauty.com WANDERBEAUTY: WanderBeauty.com

Today we bring on guest, Simon Bachofner, Crossfit owner/instructor at HubCity Crossfit. He is not only a Crossfit owner and instructor, but also a registered nurse working on a Master’s to become a nurse practitioner.  With the Crossfit movement and background, let’s dive into a few questions that can help you guide what kinds of exercise you’d like to pursue in 2020. Meredith: What’ got you interested in fitness?  Simon: I’ve always been a fitness enthusiast at heart. Through the course of my fitness journey, I’ve traveled many different directions. I started as a high school athlete playing baseball. I often tell myself if I had a program like Crossfit in high school, I would have been a much better player. I journeyed into endurance sports for a while . . . things like Triathlons. Through nursing and being a health professional . . . I’ll be honest, my wife got interested first. That’s usually how it happens; my wife get’s interested first. I was skeptical at first; I always thought it was competitive exercise back when it first started, but I’ve come to see the value in it. We’ll get into that later. There were things I found about Crossfit to be really positive early on and I’ve been doing it ever since. It’s a passion. It got to the point where I ended up opening my own gym. If people can drum up the courage to walk through the front door, it’s really not as bad as people make it out to be. We’ll get into that later too. I believe in it strongly, and I don’t think I’ll do anything else.  Meredith: I really appreciate your Crossfit and healthcare backgrounds. I run into the question every day of “is Crossfit for me? Is it good?” What do you think about the rise of Crossfit in general? Who is it good for? Simon: In level one (coach training), they teach you that Crossfit is for everybody. Whatever workout or movement you are doing is infinitely scalable. I have a class; it’s my favorite class. It’s a group of ladies who come in Monday, Wednesday, and Friday at 8 AM. They are all over 65; I think the average age is 72-74. These ladies come in and crush it. They do whatever I put infant of them; of course we modify and scale to every individual athlete’s need.  With the rise of the Crossfit games and individual competitors, we have to remember that that’s the one percent of the one percent. Crossfit, at its core, is design for general physical preparedness for your average human being. That’s the philosophy at my gym. That’s the way we program the daily workouts. They just had an open workout this past week on handstand walking. Yes, we use functional movement; that’s not a functional movement; we’re not going to program in handstand walking for the general population. Yeah, it’s cool. If you can walk on your hands, you can probably do a whole lot of other things. It can be a marker for your own fitness, but that’s just something that our general population is going to see. Crossfit is for everybody. What you see on TV shouldn’t be what’s stopping you from walking in the front door of your local Crossfit gym.  Meredith: I like that. So many times we see social media, or the Crossfit games and assume that’s what we’re going to be asked to do on day one. We’re going to be asked to do a PR of some kind of a lift, or monkey bars, or walk in a handstand. When people in their 40s, 50s, 60s, 70s that have spent a lot of time in the corporate world think they want to start fitness, what tips would you give them? How do they get started with fitness safely again?  Simon: From a Crossfit perspective, number one, you have to assess and meet them where they are at. I offer a free one-on-one fundamentals session for everybody. Crossfit has nine foundational movements build into it. I generally screen each new athlete coming in. Where they are at with those basic movement patterns of overhead pressing, squatting, and pulling movements. We run them through those movements and see where there might be faults. We don’t start by loading anything. We start with a PVC pipe.  There is a great picture I found and re-posted on Instagram of a baby bending down to pick up a ball. It maps out their angles. That’s how we were meant to move. Over the course of doing all the things that we do as human beings, like sitting in chairs and being hunched over at computer screens, things change. Our goal is to get as close to the native movement pattern as possible. We may not get there. We’re going to get as close as we possibly can, safely. You gotta be gentle; you can’t force somebody just because the workout says we’re going to work up to 1 rep max on the board; You have to know your athlete and where their limits are and work things to their relative potential.  Meredith: Sounds like you’re doing a great job of making things scalable and relative to each individual. I think sometimes people get into the Crossfit box (and I see this in my neighborhoods too) and are excited by what is going around them, but they are new to fitness. How do you help people that are new avoid doing too much too fast?  Simon: Good question. That comes down to coaching. We get a lot of folks who may have been athletes early on in their lives, but over the past 10 20, 30 years have devolved into obesity, poor movement patterns, poor range of motion and flexibility. It’s up to the coach to know. Those athletes are going to come in and think they can just go right back into doing what they did in their 20s, and that’s just not reality. You can pick those athletes out when they come through the door and have been exercising for zero minutes in the past 10 years thinking they can go right back to where they left off. You want them to come back the next day. When you let them go too hard, they’re not going to. That’s the “check your ego at the door kind of thing.” No matter where you came from, or what you used to do 20, 30, 40 years ago, you gotta ease into it.  Meredith: I like how you included the screening process. Even if people aren’t ready to start Crossfit, it sounds like everybody needs with a goal and a motivation; we can’t just pick up a barbell and throw it overhead because we could 20 years ago. We have to work back into it. I’m wondering if you can share any success stories, whether it is for yourself or people you coached where you saw a major transformation in some part of life.  Simon: I’ve got so many. When I first started, I worked with a gal named Diane. She’s now doing her 2nd Crossfit open. She has PR-ed every single one of her lifts. I couldn’t quote you off the top of my head how much weight she’s lost, but she keeps her pair of jeans in her gym bag that she used to wear when she first came in. She’s on fire now. She crushes just about everything. We did a challenge the other day, a bingo community building thing, and she did every single one of the spaces on the challenge. She’s gotten excellent results.  There’s another one that, from a medical standpoint excites me, a guy with a traumatic brain injury in 2004. He still has some residual instability with gait/walking. I don’t love when docs cap out rehab potential on patients and say “this is as good as its going to get.” This young man came in with a cane. I don’t believe I’ve seen him walk with a cane now. He started four months ago, and I don’t think I’ve seen him walk with a cane after his first month here. Pull ups, push ups, squats . . . he can even do some of the more complicated Olympic lifting movements, which is really taxing neurologically and neuromuscularly. He comes in and loves it. He’s doing great. That’s the kind of stuff that gets me going. He was told he’s walk with a cane for the rest of his life, but now he’s doing great.  Meredith: Yeah; that’s the kind of thing I share with my patients. They’ll ask “can I . . .” followed by something from the Crossfit Games or Wounded Warriors. I respond with “I’m not going to tell you that you can’t, because you’re just going to prove that I’m wrong.” A lot of that inspiration has come from Crossfit.  How is Crossfit different from other workouts? This is a common question when people want to workout, but don’t know how they want to workout.  Simon: This goes back to the question, “how do we optimize health?” My philosophy is not just developing a workout program. You can’t out-fitness a bad diet. More than that, we’re not just lumps of flesh and skin, we need to have human connection, a tribe, and the psychological piece as well. That was one of the things I noticed early on about Crossfit that was unique. It was unique in its ability to provide real human connections with other people that had a common goal. Caveat is that you have to go to the right gym and find the right people, and have the right ownership that will cultivate that community because it is important to them.  At our gym, we are not trying to send people to the Crossfit games, and that’s never what we sought out to do. We sought out to make our community healthier and build a strong social network of folks that just wanted to be the best versions of themselves.  The physical stimulus is built into the workouts, but the psychological piece . . . you get to come in, and let’s just say you are lifting heavy and trying to PR a 1 RM, but you just don’t have it that day. Crossfit is a safe place to come in and fail, and that’s important to being human. You have to be OK with saying, “I didn’t have it that day.” That’s alright.  Personally, for me, having a wolf pack, having your guys, having your squad . . . that’s a really valuable thing for men that are trying to stay healthy or regain/reclaim their health. We’re not an island. We are social beings. Evolutionarily speaking, you didn’t go out and hunt alone, you hunted in a party. Being stuck in a cubicle by yourself and then going to the gym by yourself and putting your headphones on  . . . I’m not surprised you’re not motivated to get your workout in. If you come in and show up with your boys and we’re all doing the same thing, it draws a parallel to how we used to go about doing things as men. All those things are inherently built into Crossfit. When it comes to health, I think that Crossfit hits optimization comprehensively.  Meredith: Absolutely. When people are looking to join a Crossfit gym, what are some questions they should ask to try to figure out where their wolfpack is? Which one is the right one to try?  Simon: You won’t know until you get in there and try. It’s a trial-and-error process, but I think you’ll know right away. Does somebody greet you and shake your hand? Does the coach come up and talk to you and try to just form a relationship first and foremost? What that tells me is that that gym is about people; its about helping you reach your goal; helping you reach your potential; getting to know you; getting to know your strengths and weaknesses, and working together to get you to where you want to be.  Meredith: I appreciate you sharing, as so many people coming back to fitness don’t know. Just having this as a frame of reference is a great place to start. When people are adults in their 40s, 50s, 60s . . . what are the first steps you give them, other than “come to class?” Simon: I think that you have to develop a pattern of consistency first. I haven’t seen anyone that was inconsistent get the results that they wanted. It is a little bit different with older populations. Make sure that they space out their workouts and get adequate rest in-between. Especially early on. Every other day works well. For new athletes and for older athletes this works well. Even for myself. If I go five days in a row, it takes me two days to recover. Optimizing for recovery is important. Then we get into nutrition; first and foremost, I want the athletes to stop eating garbage. Meredith: What is garbage?  Simon: Garbage is anything in a bag or box. I want them to eat things that if left on the counter would die and have to be thrown away. I want most of those meals to consist of real plants. Rule number one: eat real food. The Crossfit way of doing things is eat Paleo, meat, vegetables, nuts, and seeds, some fruit, little starch, no sugar. If you can stick to those things, you’re 90% of the way there. As you progress in your training, we can tweak nutrition to optimize performance.  To summarize, I want them to find some pattern of consistency with training and rest. The second thing would be to dive into food and nutrition. If there was a hierarchy, sleep, then nutrition, then training, then sport specific movements.  Meredith: Thank you. That really helps hi-light the link between health and Crossfit. Is there anything else you were hoping I would touch on as it relates to healthy lifestyles for busy people?  Simon: I need to mechanically move soundly with consistency before I add any intensity. Intensity can be defined as speed or weight. Slow down and revert back to good mechanics consistently. We do ask you to do challenging things, but Olympic lifting—they give gold medals for that; don’t expect to go into a Crossfit gym and ace your first snatch workout. There are certain positions and movement patterns that people spend years just to add one or two kilos. They give big gold medals for that. You have to go at your own pace with mechanics first and check your ego at the door. Be there for the right reasons; be there for the community; be there for health and your own well-being. If its not working for you at your gym, there are plenty of others. Crossfit is going back to why they started in the first place . . . for the person on the couch; getting off the couch and into the gym. I wouldn’t be scared; the hardest part is stepping through the front door.  Meredith: I really appreciate how you bridge health and fitness with what a people can find inside a Crossfit box should they have the bravery to walk through the door and take that first step.  Closing thoughts form Simon: The farther you move into fitness, the farther you move away from illness.  Simon’s contact info: HubCityCrossfit.net in Albany, Oregon. You can reach him on Instagram and Facebook as well. 

Humans like to think we can solve every mystery - that’s partly why I do this show! We have an obsession with patterns, codes, and strange symbols. Evolutionarily it meant seeing the tiger in the long grass, now it mostly means magic-eye books. But what happens when a mystery we think is solved, turns out not to be? When we go back on our original solution, for a new one? Again... and again... and again...

Adolescence is a unique developmental period of life, during which we face the challenges and pressures of moving from childhood into independent adulthood. Evolutionarily, adolescence is a time of risk-taking and growing independence, and one of the important developmental tasks is to learn to respond to thoughts and emotions in a helpful way, in order to live a full and meaningful life. In this interview, cross-posted from the podcast Psychologists Off The Clock, Dr. Debbie Sorensen interviews Dr. Louise Hayes about her book, The Thriving Adolescent(Context Press, 2015), which offers teachers and mental health professionals evidence-based techniques for understanding and working effectively with adolescents. Based in Acceptance and Commitment Therapy (ACT), the developmental model outlined by Dr. Hayes will help adolescents and teens manage difficult emotions, connect with their values, achieve mindfulness and vitality, and develop positive relationships with friends and family. Debbie Sorensen, Ph.D. is a licensed psychologist practicing in Denver, Colorado and a co-host of the podcast Psychologists Off The Clock. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/psychology

Adolescence is a unique developmental period of life, during which we face the challenges and pressures of moving from childhood into independent adulthood. Evolutionarily, adolescence is a time of risk-taking and growing independence, and one of the important developmental tasks is to learn to respond to thoughts and emotions in a helpful way, in order to live a full and meaningful life. In this interview, cross-posted from the podcast Psychologists Off The Clock, Dr. Debbie Sorensen interviews Dr. Louise Hayes about her book, The Thriving Adolescent(Context Press, 2015), which offers teachers and mental health professionals evidence-based techniques for understanding and working effectively with adolescents. Based in Acceptance and Commitment Therapy (ACT), the developmental model outlined by Dr. Hayes will help adolescents and teens manage difficult emotions, connect with their values, achieve mindfulness and vitality, and develop positive relationships with friends and family. Debbie Sorensen, Ph.D. is a licensed psychologist practicing in Denver, Colorado and a co-host of the podcast Psychologists Off The Clock. Learn more about your ad choices. Visit megaphone.fm/adchoices

2-Minute Tip: Identify Your Biggest Take Away   To deliver an effective presentation, first identify the biggest take away for the audience. If they remember only one thing, this is the thing it should be.   To figure that out, start by doing a brain dump on a piece of paper or whiteboard. Then go through all theses random ideas that are in someway related to your topic. What stands out? Which ideas are most important? What themes keep popping up?   As you do this, you'll likely discover the big idea for your talk. Once you have that, you can begin building everything else.   Post Tip Discussion: Meet Julia Wojnar   In the theater you have to know your part and how your role fits into the rest of the show. You have to know your lines and be rehearsed.   Speaking is similar. You have to know your purpose. Why are you speaking? What is your role in this meeting? What is the purpose of your talk in the larger event or conference? What are you meant to accomplish.   You have to be prepared and rehearsed to be effective. Unlike theater, you don't need to have your talk memorized word for word, but you do need to know your content.   That's what the prep work is all about.   Today's guest, Julia Wojnar comes from a theater background which helps her be an effective Public speaking trainer through her company, Unleash Your Presence.   In this conversation we talk about theater, working through nerves, identifying your purpose and speaking in different cultures.   Crazy 8s   One reason we get anxious before speaking is that our bodies don't really know how to deal with it. Evolutionarily, we are not optimized for standing in front of a group of other human animals and having the focus on us. Our fight or flight instinct kicks in. Adrenaline pumps. Muscles tense. Secondary biological processes may shut down. Muscles tense to spring into action and survive.   But it's all unnecessary. There is no threat to our lives. We're not about to be kicked out of the tribe. We need to rechannel that energy and deal with it.   Pradeepa Narayanaswamy recommended changing your language. Don't tell yourself you're anxious or nervous; tell yourself -- and others -- you're excited. And it's great insight because excitement and anxiety often feature similar physiological symptoms.   Julia offers another great way to deal with the anxiety -- the Crazy 8s (though it could use a less ableist name).   This is exercise comes from Julia's theater background where it can be a valuable warmup exercise for actors as they burn off their excess energy and get ready to wow the audience.   Take a look at the video below to learn more.   [embed]https://www.youtube.com/watch?v=NANGMbz5-Gk[/embed]   Billy Mays   I mentioned Billy Mays in this episode. If you're not familiar with him, Billy Mays was the quintessential TV pitchman of the 90s and 2000s. He's the reason so many people buy OxyClean, KaBoom, and other products.   Here is one of his videos:   [embed]https://www.youtube.com/watch?v=2PU8ZxQj7eE[/embed]   Bio   Julia Wojnar is the Founder of Unleash Your Presence where she develops professionals’ resilience, speaking, and communication skills to tackle tough decisions and express their ideas clearly and confidently.   She has honed her own speaking skills with over fifteen years of experience on stage speaking and performing, in addition to her formal training in Communications from Ithaca College.   She has been featured on The Huffington Post, Thrive Global, Hello Fearless, Grant Cardone’s Whatever It Takes Network, Savvy Central Radio (a syndicate of iHeartRadio), and The Wealth Standard Podcast, among others.   Nowadays, she speaks and delivers live and virtual trainings to help her clients bridge the gap between their brilliant idea and their ability to communicate it powerfully.   Promotions   Julia is making her Corporate Communications Check list available to listeners of 2-Minute Talk Tips. You can get that at by clicking here: http://2MinuteTalkTips.com/UYPTopTips   Julia also has a special deal for corporate managers right now.   If You're A Corporate Manager whose ready to "Set the Stage" to Lead Your Team with Clarity and Conviction…" then Julia has an online course which may be just what you need. And, she'll make Module 1 of this 8-Module series available - For FREE to the first 5 companies that qualify.   For more information and to see if you qualify, send us an email over at www.unleashyourpresence.com Links   Julia's Website http://UnleashYourPresence.com Julia's Corporate Communications Checklist http://2MinuteTalkTips.com/UYPTopTips Julia on LinkedIn https://www.linkedin.com/in/juliawojnar/ Julia on Facebook https://www.facebook.com/UnleashYourPresence/ Julia on YouTube https://www.youtube.com/channel/UC9NDo2ZNU4n6BonuuJkR4pA Crazy 8s https://www.youtube.com/watch?v=NANGMbz5-Gk Billy Mays for OxiClean https://www.youtube.com/watch?v=2PU8ZxQj7eE Amy Lyle on 2-MinuteTalk Tips http://2minutetalktips.com/Amy Pradeepa Narayanaswamy on 2-Minute Talk Tips http://2minutetalktips.com/Pradeepa   Call To Action:   Check out Julia's Corporate Communications Checklist at http://2MinuteTalkTips.com/UYPTopTips  Check out the other resources Julia has over at http://UnleashYourPresence.com Subscribe to 2-MinuteTalkTips in your favorite podcast app for free so you never miss an episode Don't get best…get better.

Allen offends some marsupials, Arik disproves Jesus, and we discuss a scheme for getting rich. The toxic culture at Revolut The “In case you missed it” regex for Tweetbot: (?i)(in.*case|if).*you.*missed.*it The “Mother of the bride dress” The day there was no news Jesus' name: Jesus' language Yeshua Yeshua to Jesus The Great Vowel Shift Index investing Buying One of Everything Why Warren Buffett recommends index investing Canadian Couch Potato Woolly Mammoths and the pyramids

Allen offends some marsupials, Arik disproves Jesus, and we discuss a scheme for getting rich. The toxic culture at Revolut The “In case you missed it” regex for Tweetbot: (?i)(in.*case|if).*you.*missed.*it The “Mother of the bride dress” The day there was no news Jesus’ name: Jesus’ language Yeshua Yeshua to Jesus The Great Vowel Shift Index investing Buying One of Everything Why Warren Buffett recommends index investing Canadian Couch Potato Woolly Mammoths and the pyramids

Evolutionarily Stable Strategies Complex Systems LECTURE EVOLUTIONARILY STABLE STRATEGIES ESS SYSTEMS EXPLAINED THE INTELLECTUAL DARK WEB PODCAST IMPORTANT! AMAZON DELETED THE LAST INEXPENSIVE BINDING. IT WAS TOO CHEAP! HERE IS ANOTHER VERSION FOR STUDENTS WITH HOBBES, LOCKE, ROUSSEAU AND THE US CONST. IN ONE BOOK: The Leviathan (1651), The Two Treatises of Government (1689), The Social Contract (1762), The Constitution of Pennsylvania (1776) in ONE BOOK for 30$: https://www.lulu.com/en/us/shop/jean-jacques-rousseau-and-thomas-hobbes-and-john-locke/the-leviathan-1651-the-two-treatises-of-government-1689-the-social-contract-1762-the-constitution-of-pennsylvania-1776/paperback/product-782nvr.html

While the mainstream news is focused primarily on a top-down approach towards food and health aimlessly tossing around observational studies, Gabor Erdosi and even us at Ketogeek are more focused on a bottom up approach starting from mechanistic ways in which food is metabolized and impacts the body as a whole. Bio: Gabor Erdosi has a masters in molecular biology and is the brains behind the Facebook group "Lower Insulin". Nicknamed the "Adipose Jedi", Gabor has a unique approach of delving into complexity and understanding the inner workings of the human body. Time Stamps: 7:32 – Background, weight loss & introduction into low carb 15:18 – Learning from thousands of scientific papers & moving beyond macro and micronutrients? 18:21 – Evolutionarily appropriate foods & finding recurring themes in successful diets 22:43 – Lowering Insulin Facebook group & focusing on high quality research 26:24 – Calorie-in Calorie-Out Model, Carbohydrate-Insulin Hypothesis and leveraging various models to troubleshoot health and address root causes 32:33 – Is it ketones or foods that promote ketosis that suppress appetite? 35:45 – How food processing can impact the body at a biochemical level 43:42 – Is Insulin Resistance a bad signaling problem? 51:10 – Feedback loops and how food processing can impact its metabolic response 55:49 – Why underfeeding and overfeeding studies may have impractical implications 58:37 – Thinking of fat gain as a protective mechanism 1:07:05 – “Compartmental Storage of Fat” and fat storage hierarchy in the body 1:012:13 – How is fat burning prioritized? 1:15:48 – Mechanistic role of intestinal barrier and gut permeability 1:20:08 – Why many conditions are acute processes going south 1:20:55 – Research you would like to see 1:22:28 – Final Plugs Guest Links Lower Insulin: https://www.facebook.com/lowerinsulin/ Twitter: https://twitter.com/gerdosi Ketogeek Links: Shop Energy Pods Amazon: https://www.amazon.com/Ketogeek-Chocolate-Energy-Organic-Vanilla/dp/B07B88S36J Ketogeek Ghee on Amazon: https://www.amazon.com/dp/B07B29HM3D Ketogeek Merchandise, Ghee & Energy Pods: https://ketogeek.com/collections Ketogeek Newsletter Sign Up: https://ketogeek.com/pages/sign-up Shop Energy Pods: https://ketogeek.com/collections/energy-pods Wholesale: https://ketogeek.com/pages/wholesale Onnit Keto Box: https://www.onnit.com/ketobox/ Citations: Satiety Index Study: https://www.ncbi.nlm.nih.gov/pubmed/7498104

We are more complicated then simply fuel in - fuel out Lots of things happen in between and these processes are mediated by hormones What is a hormone? Molecules produced by your your body that regulate many processes in your body. Hormones are influenced by environment. E.g. People have heard of Hormones will change your physiology based on external environment. This allows you to survive and adapt quickly to your environment UNDERLYING THEME: hormones in moderation and in short pulses is healthy, if hormones are elevated over time ---> many health problems Insulin Secreted from the pancreas in response to blood Stores nutrients Inhibits lipolysis Leptin  Secreted by fat cells       Makes you know your fed       If overweight - leptin resistance  (Why your hungry when overweight)       Needed for fertility Ghrelin           Made mostly in the stomach; acts on the brain (hypothalamus) to stimulate               hunger. If you want to lose weight, you want less ghrelin.                    Lowest between 7-9 am           20 minute waves           No increase longer you fast CCK (cholecystokinin) Released in the small intestine when fats and proteins are eaten. In the brain CCK depresses hunger meaning the more CCK you have floating around the less hungry you are This is one reason why a lower-carb, higher-protein, higher-fat diet make people feel fuller longer. Cortisol Secreted by adrenal gland Evolutionarily speaking it is there to get you out of danger it raises blood sugar (to feed muscles so you can run or fight), raise blood pressure, and modulate immune function. Over time, sustained high cortisol is linking to high blood pressure, diabetes, increased belly fat, brain changes such as atrophy of the hippocampus (where memory is synthesized), depression, insomnia, and poor wound healing. fat cells in the belly have four times more cortisol receptors compared to fat cells elsewhere, as your cortisol climbs / and is sustained - -> muffin top What leads to chronically high cortisol Emotional and physical stress Over exercising Sleep deprivation   Melatonin          Helps you sleep          Increases insulin resistance          Don’t eat late at night Human Growth Hormone Important for development and growth in children HGH deficiency in adults leads to higher levels of body fat, lower lean body mass (sarcopenia) and decreased bone mass (osteopenia). Goes down with aging HGH is crucial in the maintenance of lean mass – both muscle and bone. Human Growth Hormone (HGH) declines with age in every animal species. In humans, after the age of 20-30 HGH levels decline 14-15% every 10 years; by the age of 60 HGH is usually less than half what it was at 25. Exogenous HGH used in athletes/bodybuilders Tried it in others Inc risk of prostate cancer, dm to name a few 5 fold increase in HGH in response to a 2 day fast. HGH may be one reason why you see preservation of lean mass with fasting Body builders are harnessing this (Martin Birkham - Leangains)

A solid routine fosters a well-worn groove for one’s mental energies and helps stave off the tyranny of moods. In this episode of Made You Think, Neil and I discuss​ Daily Rituals by Mason Currey. In this book, Currey edits together first-hand accounts from different artists and creative thinkers of how they went about their everyday lives. “I write when the spirit moves me,”  said, “and the spirit moves me every day.” – Faulkner. We cover a wide range of topics, including: The problem with lifestyle gurus. Whether drugs enhance genius. Coffee’s role in causing the Renaissance. How people in far-off countries let each other know they were alive before the internet. Beethoven’s perfect cup of Joe. Why you should pin notes to your clothes' Night Owls vs. Early Birds - who gets more worms. Hacks to become an morning person. And much more. Please enjoy, and be sure to grab a copy of Daily Rituals: How Artists Work by Mason Currey! If you enjoyed this episode, be sure to check out our episode on 12 Rules for Life by Jordan B. Peterson for more tips on how to order your day, as well as our episode on Elon Musk to discover what rituals a modern-day success keeps. Be sure to join our mailing list to find out about what books are coming up, giveaways we're running, special events, and more. Links from the Episode Mentioned in the show: Sleep debt [8:00] Dymaxion sleep [8:46] Polyphasic sleep [9:05] Alt-right [11:55] Benzedrine [12:58] Ritalin [18:34] The Renaissance [22:26] Obsessive-Compulsive Disorder – OCD [29:10] Franklin’s 13 Virtues [32:21] How to Plan your Ideal Day by Taylor Pearson [39:48] Maker’s Schedule, Manager’s Schedule by Paul Graham [40:05] Growth Machine [40:10] On-demand economy [44:58] 1099 economy [44:58] Peterson’s guide to essay writing [51:44] Mnemonics [57:10] Keto-adaptation [59:50] Hormetic stress [1:07:55] Night Owl Mutation [1:12:36] Gilgamesh Platform [1:20:50] Books mentioned: Antifragile by Nassim Nicholas Taleb [12:28] (Nat’s Notes) (book episode) Come Again? by Nat Eliason [19:26] Benjamin Franklin by Walter Isaacson [32:21] The 4-Hour Body by Tim Ferriss [34:36] Skin in the Game by Nassim Nicholas Taleb [34:47] Tropic of Cancer by Henry Miller [48:42] The War of Art - Steven Pressfield [50:44] The Bell Jar by Sylvia Plath [1:02:18] Merchants of Doubt by Naomi Oreskes and Erik M. Conway [1:07:55] (Nat’s notes) (book episode) The Fountainhead by Ayn Rand [1:10:50] Atlas Shrugged by Ayn Rand [1:11:10] People mentioned: Francis Bacon [2:30] Nassim Nicholas Taleb [3:54] (Antifragile episode) Tim Ferriss [5:00] Jocko [5:08] Buckminster Fuller [8:46] Steve Pavlina [10:00] V. S. Pritchett [11:30] W. H. Auden [12:58] Immanuel Kant [13:58] Michel Foucault [13:58] Ryan Holiday [14:44] Beethoven [29:16] Nikola Tesla [29:34] Tom Cruise [30:37] Benjamin Franklin [32:32] Charles Darwin [36:30] (on this podcast) Henry Miller [48:42] William Faulkner [50:27] Ann Beattie [50:58] Haruki Murakami [52:37] Scott Britain [53:11] Ramit Sethi [53:11] Jonathan Edwards [57:10] Sylvia Plath [1:02:12] Woody Allen [1:02:37] Jean Paul Sartre [1:03:00] David Lynch [1:06:20] Paul Erdős [1:10:25] Ayn Rand [1:10:50] Show Topics 00:50 – Book covers daily rituals of a bunch of people, not just artists. Broad interpretation of artists, anyone who does creative or critical thinking work. 01:24 – There’s a surprising amount of drug-use in this book, lots of alcohol, and not sleeping. On the one hand this seemed undisciplined, but on the other these people did have very regular schedules. There was discipline to keep these activities in a well-worn groove. 01:53 – A hangover can make it easier to write – your brain can be more focused. In some ways it’s like the opposite of being caffeinated. 03:10 – The book has an interesting layout, there’s no attempt at narrative, each chapter is about a new person’s routine. 03:54 – Taleb keeps no routine, he doesn’t even use a calendar. 04:00 – Small gripe with books like this as these are idealized and narrativized versions of these rituals. None of them get drunk and yell at people on Twitter. Wouldn’t be surprised if they’re only true 20-50% of the time. 04:55 – Problem with a lot of the lifestyle guru type people. They don’t do all of that stuff everyday. Except Jocko, he’s never overslept in the last 15 years. His morning routine seems to be the same wherever he is. 06:02 – Maintaining a normal schedule when you travel across time zones helps you adapt way faster. The minute you go back to your hotel you’ll crash, it’s game over! Jet lag is a strange tiredness, especially if you drink coffee, like you’re wired and drunk at the same time. 08:00 – Questioning whether you can save up a store of sleep for a rainy day. Apparently you can’t front load it, but when you get into debt you need to pay it back! 08:46 – Types of polyphasic sleep. Buckminster Fuller developed dymaxion sleep, he did it for two years and he’s the only one who’s ever been able to do it. 5-10% of the population legitimately need less sleep. Everyone else thinks they’re in that group but they’re not. 09:05 – When they tried one study on polyphasic sleep the subject just crashed and they could not wake him up. 11:43 – Is it quote or quotation? Don’t want to anger the grammar people! 11:55 – Download all of our episodes to find out whether one of our team is part of the alt-right. 12:58 – Auden was popping Benzedrine all the time. He regarded it as a “labor saving device,” a daily multivitamin. In the mental kitchen alongside alcohol, coffee and tobacco. 13:40 – Were these people great producers because of these habits or despite them? Question of whether the live-fast, die-young lifestyle enhances genius. 16:22 – Personal experiences and use of some drugs. Coffee for work and productivity, micro-dosing LSD for the same. Marijuana for an after wine session. Fear of getting hooked with tobacco vs alcohol. 18:34 – Ritalin/Aterol for effortless full-speed ahead concentration. 20:12 – Doctors overprescribe Aterol – 90% of people taking it don’t need it. It’s very hard to quit, people get frustrated at never hitting the same level of quality. In some ways similar to steroids. 22:26 – The Renaissance happened when people stopped drinking beer all day and switched to coffee. 22:36 – Drinking habits around the world. Beer used to be brewed as water wasn’t safe to drink. They would steep the same grains up to four times. In Asia they would drink tea all day, which is probably why they were historically more productive than Europe. 24:55 – In sushi bars in Tokyo they have a tap of green tea. In Germany they give you beer, Americans drink water and now they’re more productive because they’re hydrated. 25:53 – Tangent – Most people who are in America now, their ancestors were the risk-takers. The people who took the initiative to leave behind everything they knew. So culturally this is ingrained. 26:59 – People used booked calls to let family on the other side of the world know they were alive before Skype. 27:40 – The history of pokes on Facebook – they would let a non-friend see your profile for a few days without actually becoming your friend. 29:10 – A significant number of people featured in the book seemed to have OCD, they were trying to control chaos. Beethoven’s coffee had to have 60 beans a cup. Kant had an extremely orderly schedule. The clock tower in town stayed on time less passionately than Kant. 32:00 – Everyone has odd habits, especially artists who spend a lot of time in their heads. 32:21 – The general impression of Benjamin Franklin is “early to bed, early to rise” but he seemed to set his 13 virtues up as goals rather than things he’d achieved. Comparing Ben Franklin to Tim Ferriss. People disapprove of others not following their own advice to the letter. 35:53 – Controversy when one updates his opinions. 36:16 – It’s surprising how few hours people worked – the bulk of the creative work was 5-6 hours a day, max. Darwin was famous for having two 3 hour work blocks. It’s hard to do creative work for longer. But good for mental energy. 38:00 – Tangent. It’s hard to be spontaneous in New York. Phone calls are scheduled a week in advance.  Time management tips: set regular stand-ups, only book meetings at certain times. Color-code your calendar. 40:30 – Work environments are moving towards being more results orientated, moving away from people just sitting at their desks doing nothing. A relic of the production line. Schedule Tetris in large corporations. 43:26 – Hack. Schedule hour meetings for 40 minutes, or half hour meetings for 20 minutes. It forces people to condense. 44:58 – Data should make it easier for people to get paid based on productivity rather than time. For consulting jobs, it doesn’t make sense to charge based on time. Historically, time was the best way of measuring output and so this made sense. 47:43 – Education is also stuck in this time loop since it was originally influenced by factory organization. Most interesting ideas that end up leading somewhere come from play, from free time. 49:21 – After unsuccessfully trying for ten years in New York, Henry Miller had given up writing, when he finally wrote a novel in Paris it was published without editing, there’s sentences that just stop mid-way. Seeing from outside, it seems these creatives are able to follow a routine without anyone forcing them. 51:44 – Jordan Peterson says there’s no such thing as writer’s block. If you’re stuck it’s because you have run out of things to say, you need to unblock yourself. 53:10 – Sleep and wake up at the same time every day, even on weekends, may make you feel much more energized. Sleeping in on the weekend it’s almost like changing time zones every five days. 56:41 – Giveaways are coming, sign up for the email list. 57:03 – To remember to do important things pin a piece of paper on a different piece of your clothing, a form of mnemonics. 58:15 – When you first wake up, that’s a different person. You have to find ways of tricking him into not hitting snooze. Routines and replacement can help you get past undesirable behavior. 59:04 – Sponsor time. Mushroom elixir from Four Sigmatic and bone broth from Kettle & Fire along with Perfecto Keto collagen. Use them to replace alcohol in the evening! 1:01:38 – Despite living in climate controlled environments, we still feel like it’s cold outside when it’s winter, even though it’s the same temperature where we are. 1:03:30 – Some people’s capacity for alcohol is so far beyond the average. If you’re regimented and disciplined you could physically drink a bottle of spirits a day. 1:07:15 – Sugar is like a mild form of cocaine. It’s a stimulant followed by a crash. Hormetic stressors are only “natural”. 1:09:20 – Psycho-active drugs don’t make your brain do things it can’t do, they mimic neural pathways. Maybe adaptation is down-regulating the amount of neurochemicals being released in response to the trigger. If you know, write in! 1:11:36 – Morning Working vs Night-time working theme. More of the creators were geared towards mornings but it wasn’t across the board. Evolutionarily, it doesn’t make sense for humans to want to work at night. 1:14:20 – Waking up hack. Trick yourself into getting up by telling yourself you can go back to bed in 30 minutes if you’re still tired. 1:14:45 – Wrap-up and sponsor time. Perfecto Keto is perfect for all your ketogenic diet needs. Exogenous coffee-flavored ketones. Their matcha MCT oil powder is highly recommended for focusing. You can use the MCT oil with a Four Sigmatic mushroom coffee or your hot chocolate, all 15% OFF through our sponsored link or use the coupon code mentioned. Kettle & Fire will give you 20% OFF on their delicious bone broths –beef recommended for cooking, and chicken for a good, hot wintery drink– and free shipping! Listen to know how to get a mushroom-flavored bone broth. And you can always support us by going through our Amazon sponsored link and checking out our Support page. 1:20:50 – The new Gilgamesh cryptocurrency is building a social network built on knowledge sharing. If you enjoyed this episode, don’t forget to subscribe at https://madeyouthinkpodcast.com

Ep. 277: Epigenetics, Adoption, and Turning Genes On and Off In this episode, Stacy and Sarah talk about epigenetics and how gene expression can be affected by different lifestyle stresses and factors. Click here to listen in iTunes   If you enjoy the show, please review it in iTunes! The Paleo View (TPV), Episode 277: Epigenetics, Adoption, and Turning Genes On and Off News and Views (0:41) This is a topic that made Sarah really excited! This is fascinating science stuff! Last year, Stacy's mom, who is adopted, tracked down her family using genetic tests from 23andMe and Ancestry.com She found her father, two full sisters and four half siblings! So crazy! Unfortunately, Stacy and her mom also found that cancer runs very prevalent in her family. And Stacy's mom found that her full sisters were really similar to her, even in minor things like interests and hobbies and laughter. Stacy was fascinated by this article about epigenetics and adoption and gave it to Sarah. Epigenetics is the system where the body turns on or off or alters genes without actually changing DNA. There are a variety of ways that this can happen like stress, trauma, lifestyle, diet, environment, etc. And it's also heritable. Discover magazine article: "Grandma's Experiences Leave a Mark on Your Genes" These epigenetic signals control a variety of things like inflammation, insulin sensitivity, neurotransmitter regulation. The emotional experiences around adoption can cause epigenetic changes in the brain. Discovery came out of experiments on nature vs. nuture. They found that rats that were groomed more by their mothers were more resilient to stress. But then they found that this was caused by epigenetic changes in cortisol pathways. They then tested the theory by switching mothers and found that the epigenetics changed for the inattentive mothers' babies. It's not nature vs. nuture; It's nature affects nuture affects nature! The theory goes now that the stress of being adopted affects epigenetics, but the new nuturing environment could reverse any damage. Adoptive parents would best be served by taking that into account and be sure of providing nuturing touch and love. Thousands of epigenetic changes are made in childhood that could affect the adult life Some companies are working on developing a epigenetic "clean slate" to reset epigenetic markers for people adversely affected by epigenetic problems. This might be harmful for some, but also could help people affected by depression, addiction, phobias and other severe challenges. Epigenetic changes could affect three generations thanks to epigenetics: stress to the mother affects the fetus, who's eggs are also developing, affecting the grandchild! Evolutionarily, these epigenetic changes make sense: they provide very quick change to genetic presentation without waiting generations for natural selection to select. We know that certain things are bad for epigenetic control: overeating, nutrient deficiency, stress, famine, etc. Stacy has noticed that snuggling her children is very good for them and her. The three generation inheritance means that grandchildren of holocaust survivors are still affected by the holocaust! They have found that it is definitely in childhood that makes the most epigenetic difference: you are much more affected by poor socioeconomic status in childhood than adulthood, for example. Some epigenetic controls are inherited, but some are wiped clean between generations. Sarah's NOVA special on Epigenetics. Two types of chemicals are epigenetic controls: Methyl groups turn off genes, Acetyl groups turn them on. So how is this affected in people with MTHFR mutations? This whole field of study is going to be explored more and more in the coming years and we'll know so much more about how to control all this stuff! Stacy is often wondering how her lifestyle might have affected Cole when she was pregnant with him during a more chaotic time in her life. Sarah says these discoveries are evidence that we need to FUND MORE BASIC SCIENCE EXPLORATION! Next week: An exciting guest! Please Rate and review us! Outro (52:06) Support us by shopping through links on our sidebars, please!

Have you wondered what are the physical limitations of your body? How much stress could you handle without losing it? How much exercise could you do without fainting? How many days could you go without getting hungry? Evolutionarily, our bodies are adaptation machines Our bodies get used to a whole range of stressors and stimuli that actually make us stronger and healthier than before. Intermittent fasting is a nutritional strategy that incorporates periods of food abstinence with feasting.  There are many reason people do intermittent fasting, starting with weight loss and ending with anti-aging. But the question I want to ask you is: How does your body respond to exercise while fasting? That's the topic of today's Body Mind Empowerment Podcast. I'm going to play you the highlights of my recent Facebook Livestream, which includes How does your body respond to exercise while fasting? What's the difference between fasting on a ketogenic diet and a diet that doesn't restrict carbohydrates?  How to avoid muscle loss while fasting? What's the best way to burn fat with fasted exercise? How to do resistance training with intermittent fasting? My personal experience with post-workout fasting And much more... If you want to tune in with some future live streams, then head over to my Facebook page and join the Body Mind Empowerment Facebook group. Make sure you subscribe and share it with someone who could use this information! Here are the links to the podcast on all platforms Link to the Video Podcast on YouTube Link to the Audio Podcast on iTunes and Stitcher   To support this podcast, then I'd appreciate if you could leave us a review on iTunes and follow me on social media. Get the Stay Empowered Black T-Shirts US Get the Stay Empowered Black T-Shirts EU    P.S. If you want to protect yourself against EMF but still sleep better, then I'd recommend you use the OURA ring. It tracks your sleep but it can be kept on airplane mode. Use the code SIIMLAND to get a -10% discount.   Stay Empowered Siim   #bodymindempowerment #fitness #biohacking

Though you're hearing this in the New Year, it's New Year's eve here, and I want to talk about a topic most of us seem to struggling with, and that's feeling stuck. WE could be feeling stuck at home, at work, spiritually, financially, or with our partner, but in some aspect of our life, almost all of us feel dis-empowered, or unsure where to turn. That goes for me as well. So if this sounds even remotely like you, then do we have the show for you! Today we'll be talking with Matt Kahn, called back on the show by popular demand – and author of the best-selling book Whatever Arises, Love That! I want to talk with Matt about the spiritual side of things, or perhaps a spiritual resolution, which seems most important to me for the new year. And I want to talk about what it really means to be stuck, and why we may even want to embrace the confusion and the 'stuckedness'…even, or especially if we're in the stinky stuff. And I want to talk about slowing down, at a time we're all speeding up. Evolutionarily we're speeding up, as a race we're speeding up, but also our to-do's are completely out of control. And at this time of year we're all thinking about new years resolutions, or how to make our to do lists, even longer. So I'd like to talk about how we can flip things on their head for the new year, simplifying, slowing things down, and giving ourselves a chance to breathe, and our spirits the chance to soar. That Plus a Question from a Miner in Australia - WHO I WISH TO DEDICATE THIS SHOW. Questions and Topics Include: Is doubt normal? How do we move past doubt? Why it's important to love the one who is doubting. How to turn the Law of Attraction on its head. Why The Secret and The Law of Attraction is actually backwards. How do we tell what is intuition? How to realize our job is not to get out of our own way. How to know we can't screw things up. How the mind works as an alert system of the heart What do we do when we're stuck? Why nurturing the one with “the issue” makes all the difference Why New Years resolutions don't stick How the Law of Attraction really works – and what it has to do with circulating energy What the George Costanza affect (from Seinfeld) has to do with The Secret What Indirect Manifestation is and what it means for us Why the answer is circulating energy to get unstuck Why manifestation comes from doing things differently What's the importance of doing things differently What different is good. The importance of getting rooted in one's body. How To Get Unstuck & Shift Your Life for the New Year - Plus A Spiritual Look at the Law of Attraction & Manifestation – Plus Resolutions & Happiness! Matt Kahn - Whatever Arises, Love That - Spirituality - Inspiration - Motivation - Health - Self-Help For More Info Visit: www.InspireNationShow.com

Though you're hearing this in the New Year, it's New Year's eve here, and I want to talk about a topic most of us seem to struggling with, and that's feeling stuck. WE could be feeling stuck at home, at work, spiritually, financially, or with our partner, but in some aspect of our life, almost all of us feel dis-empowered, or unsure where to turn. That goes for me as well. So if this sounds even remotely like you, then do we have the show for you! Today we'll be talking with Matt Kahn, called back on the show by popular demand – and author of the best-selling book Whatever Arises, Love That! I want to talk with Matt about the spiritual side of things, or perhaps a spiritual resolution, which seems most important to me for the new year. And I want to talk about what it really means to be stuck, and why we may even want to embrace the confusion and the 'stuckedness'…even, or especially if we're in the stinky stuff. And I want to talk about slowing down, at a time we're all speeding up. Evolutionarily we're speeding up, as a race we're speeding up, but also our to-do's are completely out of control. And at this time of year we're all thinking about new years resolutions, or how to make our to do lists, even longer. So I'd like to talk about how we can flip things on their head for the new year, simplifying, slowing things down, and giving ourselves a chance to breathe, and our spirits the chance to soar. That Plus a Question from a Miner in Australia - WHO I WISH TO DEDICATE THIS SHOW. Questions and Topics Include: Is doubt normal? How do we move past doubt? Why it's important to love the one who is doubting. How to turn the Law of Attraction on its head. Why The Secret and The Law of Attraction is actually backwards. How do we tell what is intuition? How to realize our job is not to get out of our own way. How to know we can't screw things up. How the mind works as an alert system of the heart What do we do when we're stuck? Why nurturing the one with “the issue” makes all the difference Why New Years resolutions don't stick How the Law of Attraction really works – and what it has to do with circulating energy What the George Costanza affect (from Seinfeld) has to do with The Secret What Indirect Manifestation is and what it means for us Why the answer is circulating energy to get unstuck Why manifestation comes from doing things differently What's the importance of doing things differently What different is good. The importance of getting rooted in one's body. How To Get Unstuck & Shift Your Life for the New Year - Plus A Spiritual Look at the Law of Attraction & Manifestation – Plus Resolutions & Happiness! Matt Kahn - Whatever Arises, Love That - Spirituality - Inspiration - Motivation - Health - Self-Help For More Info Visit: www.InspireNationShow.com

Turning Point- a GPS for your Success with Host Judith L. Harrison Working with material from Mike Dooley, we will “learn how to focus your thoughts, choose your words, and decide upon the physical steps you need to take in order to achieve the changes you desire”. Turning Point – a GPS for Success will explore success elements, the role of stability, and the learn-able navigational skills and practices that can help us on the journey of the life of a business and the business of a life. We look at what is “It” that keeps us running harder & faster, relentless in the pursuit thereof – the “It” factor? Why is it that we get smarter with technology, connect more broadly with Social Media, travel further afield than ever and yet continue to destroy ourselves (& others) with war, gender abuses, medication, and a growing incidence of disease to name but a few? Isn’t it time for a “Turning Point”? www.judithlharrison.com

How far back can we trace our irrational behaviors and cognitive biases? Evolutionarily speaking, why do we even do these things? Can we blame our faulty logic on our cultures and institutions, or should we blame it on our biology and our genetic inheritance? Our guest on this episode is psychologist Laurie Santos who has created a novel approach to solving these questions - a marketplace where monkeys learn how to use money just like humans, and where they tend to make the same kind of mistakes as well. See omnystudio.com/listener for privacy information.

Lisa Kiefer interviews co-founders Tim Jahnigen and Lisa Tarver. Their project is to enable play in the most destitute communities for its health benefits. They have designed a nearly indestructable ball, which they give away, to aid the effort.TRANSCRIPTSpeaker 1:Okay. It to the madness is next. Speaker 2:Okay. [00:00:30] You listening to method to the madness, a biweekly public affairs show on k a l x Berkeley Celebrating Bay area innovators. I'm Lisa Kiefer and today I'm interviewing Tim Yon again and Lisa Tarver, cofounders of one world football now one world play. Speaker 3:Okay. Speaker 4:[00:01:00] Berkeley innovators, Tim again and Lisa Tarver launched oneworld football during the 2010 world cup from a vision that Tim had after seeing new stories about the plight of children in war zones, refugee camps, and harsh inner city environment around the world, research has shown that whether you're a child soldier, [00:01:30] sex slave, or gang member, the only therapy that helps us rediscover our humanity is to simply play. Tim found that although there are plenty of organizations that offer play therapy to refugee camps and inner city youth, there's nothing to play with because the environment is so harsh and inflated. Ball has an average life span of about an hour and remote locations or lack of resources mean it can take months to find replacements to solve this problem. Tim and Lisa started the oneworld football [00:02:00] project and created the world's first ultra durable ball with their B Corp status, meaning triple bottom line of people, planet and profits, and through the help of founding sponsor Chevrolet as well as a global network of partners and they're buy one give one customers. Speaker 4:They have managed to distribute over a million balls to communities around the world after assessing the impacts of their efforts. Tim and Lisa have found that regardless [00:02:30] of geography or culture play forms stronger individuals, builds better communities and create a much more positive future. The oneworld football project, it's just the first step toward realizing a larger goal more than just equipment. They now want to help bring the transformative power of play into people's lives. Thus, they are changing their name from one world football project to one world play project, changing the name to expand the mission products, services [00:03:00] that enable play in all of its forms anywhere and everywhere around the globe. I was lucky enough to have Tim and Lisa join me here in the calyx studio. Speaker 1:Can you talk a little bit about Speaker 4:the international challenges you've had, getting this ball out and then we're going to talk about where your next evolution is to one world play. [00:03:30] Sure. One world football project works with organizations all over the world. And actually I'd love to talk not just about the challenges but about how amazing it is, um, to be working with a network of, uh, you know, hundreds of larger organizations and literally thousands of small organizations. You know, we work with everything from, um, save the children and United Nations, you know, UNICEF and Unh cr, everything from that to tiny little organizations that [00:04:00] work in one community with 50 kids. Like even here in the u s Oakland maybe or Berkeley. Exactly, exactly. It's worldwide. I mean, we've, we've delivered one real footballs to over 70 countries in large quantities, meaning 5,000 or more balls in some cases. Um, you know, 50, 60,000 to a country. Speaker 4:We, in September, we delivered our millionth ball in South Africa together with Chevrolet, which was a huge milestone because we, we don't give [00:04:30] balls to individual children. They all go to organizations that work with disadvantaged communities. We average about 30 children per ball, which means that over 30 million children and young people are having the opportunity to play your evolution now is going from one world football to one world play. What is that all about? When we started out and when Tim had the idea for the ball, we just saw that it was the ball and we knew the ball was a tool and that we needed to [00:05:00] get it out to kids and children in all of us. I mean, we all need to play. So it's not just limited to children all over the world and particularly in the harshest environments. And that's really what it was designed for. Speaker 4:What we've realized and learn through the process is, um, you know, we knew play was important, but we hadn't realized the depth of that concept and how important it really was. You know, children having the opportunity to play when they faced trauma of, you know, [00:05:30] being coming orphan, seeing their parents killed in a war situation or ending their families ending up in refugee camps. Play is so fundamental to recovering not only physical but mental and psychological health, spiritual health and to becoming whole again and not only for the individual but for communities as well. So as we've expanded our understanding of play, we're becoming the one we'll play project we see not Speaker 5:only delivering the football, but [00:06:00] being a vehicle for all kinds of opportunity for play. So whether that's other balls or sports products, whether that's play spaces, supporting play in lots of different ways and [inaudible] and encouraging dialogue about play and supporting other people who are doing work around play. I mean we see even in our, you know, in schools in the u s play has been almost virtually eliminated sports programs, music, which is another form of play, afterschool programs, they're all just being cut out. Kids don't learn if they can't play. What's your [00:06:30] first initiative as one world play? We have several things in the pipeline. For example, the second most played sport on earth after football or soccer is cricket. Most people have no idea, you know. So we've gone on the ground. In fact, our, my director of product development who helps take my brain dump and turn it into reality. Speaker 5:He's in India right now doing the final testing on this ball. This ball looks and function. It looks just like a traditional cricket ball, but everything about it's engineering [00:07:00] has nothing to do with what we, what we know of as a cricket ball because cricket balls are rock hard about the size of an American hardball and they're made for playing on big open space. But hundreds of millions of people, 700 million people play cricket in India. Uh, hundreds of millions of people around the world play this sport in little alleyways and courtyards. So it's small children and old folks standing around watching the game. And if they got hit with a ball like that, it could hurt them very badly or damage the small cardboard shacks [00:07:30] that these people are living in as well. So we had to, we had to see what they were actually playing with, which is like a tennis ball, but that bounced too high. Speaker 5:So we had to make it a little heavier than a tennis ball. And take some of the bounce out and so on. So we actually went on the ground around the world and saw with the majority of humanity's actually in reality playing with, that's the same with the soccer ball and we're working on several other things. So you'll see things coming up. Some of the things I'd love to be shouting from the rooftops about right now, but okay. So, um, where do you do your manufacturing for [00:08:00] all of this equipment? We would have done it right here at home in the states, but there was no real machinery any longer in the states that works with this particular material. We started off with our closest neighbor. There was a, there was a company in Canada that, uh, had a machine that was, had some knowledge of how to work with this material, but we found we needed to evolve to a higher level of actual knowledge and innovation expertise. Speaker 5:We ended up moving production to an extraordinary group of, uh, to an extraordinary manufacturing partner [00:08:30] that we work with in Taiwan. But it actually costs us more to make the ball there than it started off with. In Canada, we weren't concerned about bringing down the price per se because first of all, this is the first change in ball technology in nearly a thousand years. Therefore, there is no comparison. You cannot compare the two. It's apples and oranges. The only thing it has in common with the common inflated ball is the Word Ball and the shape. Everything else about it is different. Therefore, it just costs what it costs and [00:09:00] the purpose. This ball out of context, even though it's the first really high tech version of that, one of the oldest objects in our, in history, in our evolution, it is. It's an entirely different process and we're only competing against ourselves. Speaker 5:If we were to just be a commercial product, we would have to spend an extraordinary amount of money and fight for shelf space, but this is something entirely different. We don't look at this as a nice to have. This is fulfilling a biological imperative. We call this [00:09:30] ball social nutrition when it hits the ground. In order for us to meet the global population, the need for play on a social nutrition level worldwide, which is as important as food and medicine and shelter, which people 25 and under who live in abject poverty and war zones and gang territories, inner city right here in the u s and so on, worldwide 25 and under down to infants is two and a half billion people and at 30 people per ball, it's more than 80 million balls are needed just to fulfill a basic human need. [00:10:00] This is not even about rights rights can be negotiated. There is no gray area here. In order for us to fulfill that through partnerships, every major corporation who can sponsor and so on, everybody gets to be the hero for that, for the rest of our generation. Speaker 4:So now that we're not just one real football project but one role play project and we're branching out beyond the, the initial idea of the soccer ball or football into other products, other types of activities and play spaces and other ideas of [00:10:30] how to provide opportunity for play. Um, with the idea of reaching that much more quickly on that much more of that population that globally that needs to have the opportunity to play. It's interesting that you say it's manufactured in Taiwan because I was reading that the, the earliest ball that they have found was what is now China, but it's something like 8,000 years ago they found evidence of a playing ball in China that is exploring what is now China. Yeah. And so when you talk about the theory of play, [00:11:00] I mean, you know, we've, we didn't really start analyzing it until Socrates actually, and um, Aristotle had writings about play, the, the, the idea play and its importance, but to evolve, as you guys probably know over the years, it wasn't really until the 1990s that it became known that it was used, usable for conflict resolution. And now of course the um, the data is amazing saying that the entire neocortex lights up during [00:11:30] play for not just us, all mammals and that it is necessary for evolution, particularly for social animals, pro social. So I'm sure you guys have done a lot of this kind of academic research. Who are you working with in the theory of play today and what do you, what do you know about the science of play? Speaker 5:We are reading and studying as much of the best work that's out there. There, there are some really seminal works that go back 30 or 40 years, but more recently the [00:12:00] work of Dr. Stuart Brown, founder of the, uh, National Institute for play is an extraordinary source and a resource for us. And we are privileged to the early days of discussions of collaborations with him and his work directly. But there are so many incredible people around the world on the ground whose knowledge and ideas haven't even been put on paper yet. And that's the privilege for us. I mean, play is used for not just conflict resolution and [00:12:30] Lisa can speak more to the all the variety of ways, uh, with all these incredible organizations. They're doing some of the most important social impact work on the planet today, but they're anonymously doing it in a way that the people on the ground in the Congo, in Palestine and is real letting children Palestinian-Israeli children mixed together and so on. Speaker 5:It only takes about 20 minutes of play to actually break down all the barriers of assumptions about race, gender, religion, [00:13:00] culture, language, all of those things go away. This just happens to be the centennial of the Christmas Day. Truths of the first Christmas Day, truce of World War One happened. It's an extraordinary phenomenon among other things. One of the final things that happened on that incredible day is about 40 or 50 combatants from the allies, the British and the and, and the Germans kick a, an old leather ball around in the no man's land for about all of half an hour. And that's all it took. So the next day when [00:13:30] the war was supposed to start again at dawn, those 40 to 50 guys could not shoot at each other. They had to replace them on the front in order to get the war going again. And that's a profound historic fact. You know, we have historic evidence of even going back to the truces that were called for the earliest Olympics. They used to call a halt to hostilities so that they could go home and, and compete. And that was what the Olympics used to be about. He actually is a standing statute that they're supposed to be a cessation of violence during the Olympics. Speaker 4:Yeah, I think in the [00:14:00] 19th century they actually thought play was a precursor to learning how to fight in battle. So we've come completely in an opposite direction as to what the real reason behind play is. Evolutionarily we do, as Tim said, we, you know, work with Stuart Brown. We're part of the U s play coalition. You know, we are certainly doing our own theoretical research, but really a lot of what we feel that we bring to the table is the on the ground experience with all of the organizations [00:14:30] that we work with. And um, the, the, you know, we not only provide the ball, which is really just a tool for them to use in their programs. So we work with organizations, for example, in Haiti together with the Tony Sana Foundation, Tony Sauna being a former u s soccer player, his foundation working with a group called the Haitian initiative and we've provided balls to them. Speaker 4:They're working in [inaudible]. It's the largest, one of the largest slums in the western hemisphere. Uh, just goes on for miles and miles and miles. [00:15:00] It's somewhere between 350,000 and 500,000 people live there. Incredibly dangerous, no running water, no electricity, gang warfare, um, drugs. Just really, really very challenging circumstances. What Haitian initiative is doing is working with young people. They have to stay in school in order to participate in the program. They come after school every day and they get soccer training and they get quite high level training. Um, Tony and other people are there, [00:15:30] you know, he's there periodically and, and they've received training for their coaches. They get tutoring if they need it. The directors of the program, if they, they have to turn in their, their report cards and if they're have, if they're struggling in school, they get home visits, they get tutoring, they get a hot meal, which is sometimes their only meal of the day. Speaker 4:I had the opportunity to visit the program in, in May and they are so engaged and grateful for the opportunity that they're having, [00:16:00] but they're learning so much through it that these kids all talk about how, um, how they want to give back. The kids there in the program are becoming the coaches and they're staying in school and they're graduating and they're going to college and they're getting, having new opportunities all through this, what's at the core, apparently a soccer program. And so that this is just in the four years since you've started this, I assume you're measuring the success so that you have a body of research [00:16:30] to fall back Zackly right, exactly. So we have, we not only deliver the balls, but then we work after the fact to see where they are, what's working, what's working. Um, what kinds of programs, what, you know, testimonials, all kinds of documentation. Speaker 4:And through the monitoring evaluation, are you reaching places that are hard to reach, like Iran and North Korea, Afghanistan, Pakistan. Are you in those areas or can you be, and how do you get into these challenging areas [00:17:00] with these balls? Yes, as many of them as possible. We can't ship to countries that are on the, unfortunately on the u s you know, no trade lists. So, um, Iran and North Korea have not been possible, although we have partners that are very interested. We could, if it was, you know, legally possible, but other places, you know, we, Tim and I just visited Chad. We have containers that are balls about 15,000 balls that are on their way there right now. Um, we visited the, the [00:17:30] [inaudible] refugee camps on the border with Sudan and talk about remote locations. I mean, there is nothing, you just fly for hours in a little plane over desert. And these camps are in the middle of nowhere. No roads, no roads, no, I mean it's just, you know, the, the vehicles you're just driving across the sand. Speaker 5:There is nothing there but it with armed convoy to get out there. But we're working with the UNH CR who takes in all their materials and so we get the containers [00:18:00] to country and they said, no problem. We'll get them to the camps. So you know, the ball's always go to the places your balls are shipped to? No. On the ground. No. In fact, at the, at the beginning it, you know, when we were operating on a shoe string, you know, we'd hear stories from everybody, but we were pretty much just based here and, um, and not getting out into the field. And it takes a lot to get there and we couldn't go every place. So we also have, you know, we have a regional office in Kenya and in Thailand [00:18:30] and Brazil. So our regional people are out in the field as well. Speaker 5:And indeed you start the regional thing or have you always had distribution? Like I guess we started our second year just in Kenya and then we added the other offices as we went along. We'd managed to get balls for example, using common sense and trusted freight forwarding partners and so on. There was an NGO that helped us get balls into Mogadishu, into Somalia. A country that has no functioning government, they're [00:19:00] still doing business, right. Goods are coming and going. So there are ways and we've gotten balls into eastern Congo, some of the harshest places on earth. Gosh, I can imagine that you guys would be great guests at the u n sometimes speaking. Had they ever asked you to come out and speak about this? Oh, actually bragged that my wife, I already spoke at the UN, but she was at a conference that was happening in at the facility, but it wasn't, it wasn't a UN conference addressing the cause. Speaker 5:It's the very thing that they are always trying to do is find ways to bring reconciliation and peace. [00:19:30] Well they actually have their own, the UN has its own conference on sport for Development and peace and so you know, we attend and we're part of that movement. Sport for peace and development is likely the single largest, one of the largest movements on earth that really nobody knows about. But there's so many governments and celebrities and powerful organizations doing it right now, right under our noses. We just don't know the term for it. And why do you think so many people don't know about this? What is the barrier there? That's [00:20:00] a good question. Isn't the news picking this up? The news doesn't cover the good things to cover the catastrophes and the murders and everything else and you and we don't have a culture of celebrating play and celebrating the positive and celebrating the growth. Speaker 5:So it's people like you who are giving us the opportunity to talk about it and how important it is. There's so many new brain studies now about play that that. I'm just curious why that hasn't been more out in the forefront, but it will be asked to do with, I think [00:20:30] our enculturation, Western values are based on, you know, work and children shall be seen and not heard and things like that. It's true. And the puritans believed that play was sinful, so they separated it. Right? And so you know, we're about celebrating every form of play. And the fact is play is so important of the top 10 things you must do. You can find this in the UN literature. When you're setting up a refugee camp, you have to, you know, you have 10 things you have to do. The first three things most westerners focus on, which is food, medicine and shelter. Speaker 5:[00:21:00] They triage that immediately. But school doesn't come til six or seven on that list of top 10 things. The fourth thing that you have to do, not separately but simultaneously, is play. The minute you bring a ball into a situation where you have what they call an improvised community in chaos because even a refugee camp, it may be the same country like uh, in Syria, but they may come from different neighborhoods. So it's not like you can just throw them all together and they may practice different religions or different sects of religion. It's not a homogenous thing. So [00:21:30] people whose lives have been turned upside down, they're so stressed. As soon as you put a ball on the ground, immediately structure and normalcy, it keeps them grounded in honorable conflict resolution, which they know how to do through the play and it gets stress relief and all that creativity, everything. So you must do those things simultaneously. That's how important it is. Speaker 4:You've told me about your inspiration for this company and now I'm curious, how did you two find each other? Cause you obviously have similar aspirations. Well we actually met when we were 16 [00:22:00] but didn't get together until we were 40 42. Yes. Speaker 5:Journeys of our own. That led us on very quite different geographies and different paths, but very similar outcomes. Speaker 4:You were both in El Salvador for some time, is that correct? I lived, I lived in El Salvador for five. Tim has visited, but the, when you were in El Salvador you were working on a lot of projects for people in need of help, but can you talk about that just a little bit, what you were doing there? Sure. I mean my, my background is in the Israeli, in [00:22:30] primarily the nonprofit work and both in the u s and in El Salvador. I lived there for more than five years before that. I spent a lot of time there, traveled there extensively, including during the war and at some of the most intense times in the war and you know, was working with, and as part of the u s solidarity movement at the time, we took delegations and groups down that provided, uh, not only support but a physical presence in support of trade unions and farm worker [00:23:00] organizations and displaced communities that were displaced by the war, internal refugees having a presence there would many times keep those people safe. Speaker 4:So it was very, it was a very direct form of support, not theoretical. It's like our bodies are in this office, maybe it's not going to get bombed today. We're in this demonstration, we're marching down the street with you. We're showing our solidarity, keeps the National Guard from opening fire on the delegation, you know, so that direct connection and, and then I [00:23:30] ended up moving to El Salvador and I lived there for five and a half years. You know, living in, you know, a country that's has, that's very resource poor with tremendous poverty. You know, you're directly connected with and seeing on a day to day basis how, how most of the world lips so can see where Speaker 5:your evolution to this kind of a concept would happen. And I had traveled the world, I lived in Europe, in north, in Norway for years, but I worked on a cruise ship when I was in my twenties that went around the world five times in the four years that I worked on it. So I got to see firsthand [00:24:00] how really the most of the world lives, which is in abject poverty. I just came from that direct experience. The truth of the origin of the the ball too is that, you know, I had the vision after seeing this story, but we were not financially able to pursue it at the time. We have another startup at the time and based on another technology that I'd come up with. And so we were focusing on that and we just couldn't, there was no way to do it. And, but I also work in the music business as a lyricist and producer and two years later during an amazing breakfast that we were invited to with [00:24:30] somebody that I helped work with in production for staying, uh, one of the most extraordinary people on earth. Speaker 5:He and his wife are just amazing people. Anyway, we were, Lisa and I were invited to breakfast and we were having just a random rambling conversation about things that we were thinking about and wanting to do when he shared with me a story about how he and some friends had helped finance the building of a soccer field in Gaza because he knew that it was important for children to have someplace to play in these places. And I went, wow. Well that's interesting because two years ago I saw this [00:25:00] news story that broke my heart, but inspired me to use this material someday to make a ball that will never go flat. And that was it. And all of a sudden he stopped. He goes, wait a minute, did you just tell me that you know how to make a ball that'll never go flat? And I said, well, yeah, I think so. Speaker 5:It's a theory. He goes, you need to do that right now and if you will, I'll finance that. I mean, it was, you're not even, not even 60 seconds. He didn't even, this was not planned. This was all just serendipity. We were just invited to breakfast and we were talking about, you know, literature and family and children [00:25:30] and you know, anything but music. And um, and we've even donated some of the balls to their, the projects that they're working on because wherever children are a ball should be. So we were very open about who delivers it. So he later he gave the ball the name that it has one world because I had all these other names and I wouldn't have been so bold to say one world, which is, you know, it's a pretty bold name, but I sent him this list of names and he, I said, what would you call it? Speaker 5:You understood what it was, you tell me. And he said, how about one world? And I said, fine, but you got [inaudible] give [00:26:00] me license to use your song. Did He, I guess he did. He said, fine. You know, boom. So that's our theme song. Oh, that's really great. Yeah. Congratulations. I mean, and it's so natural and organic and it's so human. What an extraordinary thing. And I think the first thought that went through my head conscious after I've almost passed out hearing that he wanted me to do this, you know, I wasn't, it was just mind blowing. The first actual thought that I was able to conjure was, please God make this so successful that I can do for someone else what he just did [00:26:30] for me. Yeah. That's Nice Tim and Lisa, I really appreciate you being on this program. So glad you're in Berkeley and I know you're about to leave the country for or this project. I know there's a lot of listeners out there are going to want to get ahold of you or look at your website. Can you give us some information where Speaker 4:people should go if they want to either help out or just read about you, what should they do? Of course, our website is one world play project.com and that's where they can find us. There's lots of information, there's lots of great stories and videos and what the impact [00:27:00] is that we're having already. Um, with the one role football and we are all about collaboration. You know, we welcome ideas and initiatives and uh, you know, the ball is available for sale as a buy one give one. So for everyone that's purchased, we donate a ball to one of the organizations that we work with. And we also work with lots of different kinds of organizations on campaigns. So for example, if there's an organization that wants to do something, a great way to become involved is to reach out to their supporters and, and let them know what [00:27:30] we're doing and encourage people to either buy a ball for themselves and we donate one or to just give a ball. We have that option as well. We can host that campaign on our website and it's, it's a fun way to work together and a great way to get started. So in lots of other ways to become involved too. So we welcome all kinds of initiatives. Speaker 5:I just want to encourage all entrepreneurs out there who have vision that have a belief that they can do something that actually helps people to, to really look into how you can be a B corporation [00:28:00] and how you can find a way to do well and do good at the same time. Also to realize that it's, it is a team. We have an extraordinary team. Everything that we do from shipping to, you know, sales, everything. Because it's such a new world of doing business this way. We actually have to make it up as we go along. We have to use best practices, but we have to make a hybridization. We're learning as we go. There is no template. There was nobody, you know, there's, we're throwing bread comes behind us and we're, we're available to answer questions and to [00:28:30] encourage people, but our time is so limited as well. So we can't always respond quickly. But the point is that the need is there. The opportunity, especially when we put play in its pride perspective, I believe that there's a, there's a future that has a, an opportunity for innovation that would make the innovation of Silicon Valley and the dotcoms almost insignificant compared to the, when you actually take play into consideration when you're developing and moving forward. Thank you for being on the program. Speaker 1:[00:29:00] [inaudible] Speaker 2:you just heard Berkeley innovators, Tim Yon again and Lisa Tarver Co founders of one world play contract. I'm Lisa Kiefer and I have been your host for method to the madness, a biweekly public affairs show on k a l [00:29:30] x Berkeley Celebrating Bay area innovators. If you have questions or comments about this show, go to the Calex website, find method to the madness and drop us an email. Speaker 3:Tune in again in two weeks at the same time, have a great weekend. See acast.com/privacy for privacy and opt-out information.

When it comes to what humans find attractive, many factors play a role. Evolutionarily speaking, we tend to be attracted to symmetry and markers that indicate health and wellness. In social terms it has more to do with what’s in fashion at a given moment. But it's when we begin to react to attractiveness that things get tricky. Our brains tend to make a lot of judgments that our rational selves would think absurd. One of them has to do with opportunities we afford to attractive people that we may not give to those with less appealing features. In this same vein, some studies show that women are considered less competent when compared to men just because they’re women. How can we correct for our unconscious biases? It takes more then just being aware they’re there. In this episode of Two Guys on Your Head, Dr. Art Markman and Dr. Bob Duke take us through some of these quandaries.

We study conflict between two groups of individuals. Using Schaffer`s (1988) concept of evolutionary stability we provide an evolutionary underpinning for in-group altruism combined with spiteful behavior towards members of the rival out-group. We characterize the set of evolutionarily stable combinations of in-group favoritism and out-group spite and find that an increase in in-group altruism can be balanced by a decrease in spiteful behavior towards the out-group.

Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and causing a variety of different diseases. They possess dsDNA genomes ranging from 120 to 240 kbp encoding between 70 to 170 open reading frames. We previously reported the protein interaction networks of two herpesviruses, varicella-zoster virus (VZV) and Kaposi's sarcoma-associated herpesvirus (KSHV). In this study, we systematically tested three additional herpesvirus species, herpes simplex virus 1 (HSV-1), murine cytomegalovirus and Epstein-Barr virus, for protein interactions in order to be able to perform a comparative analysis of all three herpesvirus subfamilies. We identified 735 interactions by genome-wide yeast-two-hybrid screens (Y2H), and, together with the interactomes of VZV and KSHV, included a total of 1,007 intraviral protein interactions in the analysis. Whereas a large number of interactions have not been reported previously, we were able to identify a core set of highly conserved protein interactions, like the interaction between HSV-1 UL33 with the nuclear egress proteins UL31/UL34. Interactions were conserved between orthologous proteins despite generally low sequence similarity, suggesting that function may be more conserved than sequence. By combining interactomes of different species we were able to systematically address the low coverage of the Y2H system and to extract biologically relevant interactions which were not evident from single species.

Wed, 1 Jan 1986 12:00:00 +0100 http://epub.ub.uni-muenchen.de/8230/ http://epub.ub.uni-muenchen.de/8230/1/8230.pdf Weber, Bernhard; Schempp, Werner; Wiesner, Henning Weber, Bernhard; Schempp, Werner und Wiesner, Henning (1986): An evolutionarily conserved early replicatig segment on the sex chromosomes of man and great apes. In: Cytogenetics & Cell Genetics, Vol. 43: pp. 72-78.