Podcasts about computational

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Hab ihr ’ne App geschrieben, Band-Fotografie, Schuhe putzen HS Workshops Workshops HS Workshop-Newsletter Statt Werbung DANKE an alle Spender HSFeedback von Roland: Rückmeldung über eine Ausstellung, „What the Fake“ Stadtmuseum in Arau. Ebenso „New Realitys“ – im Kalender verzeichnet von Hendrik: bei … „#932 – Nahstelleingrenze“ weiterlesen

Bone loss doesn't start when fractures happen — it begins years earlier. In this episode, we explore how bone aging accelerates during menopause and the emerging role of the gut microbiome as a driver of skeletal decline. Dr. Kara Fitzgerald speaks with research scientists from Sōlaria biō, the company behind Bōndia, about their work studying plant-derived microbes, microbial synergies, and the connections between gut health, inflammation, and bone loss in peri- and postmenopausal women. We also review findings from a randomized, placebo-controlled clinical trial examining a microbiome-based intervention for bone health — and discuss why bone loss may need to be addressed earlier, systemically, and beyond hormones alone. Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/ GUEST DETAILS Alicia Ballok, Ph.D. is Director of Discovery at Sōlaria biō, leading research on plant-derived synbiotics for inflammatory and immune-mediated diseases. Trained in Microbiology and Immunology at Dartmouth, with postdoctoral work at Harvard Medical School and Massachusetts General Hospital, her work focuses on translating host–microbe science into therapeutic innovation. Mark Charbonneau, Ph.D. is Vice President of R&D at Sōlaria biō. He earned his Ph.D. in Computational and Systems Biology at Washington University in St. Louis, studying infant microbiome development and undernutrition. His work spans microbiome research, bioinformatics, and live biotherapeutic innovation. THANKS TO OUR SPONSOR Sōlaria biō: http://bit.ly/SolariaBio EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS Looking for a clinically proven way to target bone loss? Bōndia by Sōlaria biō is a groundbreaking blend of plant-derived prebiotics and probiotics shown in a clinical trial to improve bone density outcomes by 85%. Try it for yourself at Sōlaria biō and use code Kara20 for 20% off your order. CONNECT with DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Teure Hardware, Banderole, KI für Telefonkonferenzen, Döner HS Workshops Workshops HS Workshop-Newsletter Statt Werbung DANKE an alle Spender HSFeedback Von Harald: Artemis II – der Weg zum Mond Robert: Keine Kameraarbeit mehr in der Lokalpresse Manuel: Daten zur Hörerdemographie Followup von Dieter … „#931 – Hochkariert“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

In this week's episode, Cassia has a conversation with Dr Paul Sutcliffe about computational maths, solitons and some experiences from his PhD and postdoc years!01:20 - Paul Introduction 05:45 - Computational maths module09:19 - Teaching experiences 15:50 - Mathematical Journey up to now22:33 - The aim of a postdoc & solitons37:20 - On writing a book46:01 - Nothing interesting/ switching it around47:00 - Paul's experience in finance58:52 - The theme song to a theorem

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Olympia und anderer Sport HS Workshops Workshops HS Workshop-Newsletter Statt Werbung DANKE an alle Spender HSFeedback #hshi von Martin: Mehr Moni! #hshi von Jürgen: 120er Redscale Rollfilm #hfeedback von Frank: Linksäugigkeit ist ein Ding News Nikon mit Verlusten Washington Post Staff Photographers … „#930 – Fahrenden Dingen hinterherfliegen“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

K-12 students, educators share how they are using artificial intelligence in the classroom No matter where you went to school, there is one task that has united most of us in misery — homework. Perhaps you remember staying up all night writing an essay on a Shakespeare play that you, of course, waited until the last minute to read. Or maybe you remember those grueling hours at the dinner table, as a parent helped with impossible algebra homework. Today's students have a different tool to help with their assignments — artificial intelligence. A report from the digital rights nonprofit Center for Democracy and Technology last year found 85% of teachers and 86% of students reported using AI in the classroom. Students can now use AI to summarize complicated texts and even write entire essays for them. They can type a math problem or chemistry equation into Chat GPT or Gemini and have it solved instantly, no hour-long sessions with a parent needed. Educators and parents have mixed feelings about the prevalence of artificial intelligence in the classroom. It's even prompted the Ohio Department of Education and Workforce to require all public K-12 school districts to adopt official AI policies by July. But what do high schoolers think about AI? How is it shaping their learning and outlook of their futures? Reporter Anna Huntsman has been traveling to schools in Northeast Ohio to find the answer to that question, and she'll share what she's learned on Tuesday's “Sound of Ideas,” as part of our week-long series, Ideastream Explores: Artificial Intelligence. Artificial intelligence pioneer discusses the origins of machine learning Later in the hour, early research in artificial intelligence used the human brain as a model for building machines that could understand language — today's large language models, or LLM's. Computational neuroscientist Dr. Terrence Sejnowski at the Salk Institute in San Diego is a pioneer in the field. He spoke with Ideastream's Jeff St. Clair about the links between humans and artificial intelligence and the push to build even smarter machines. Guests: - Lauren Angelone, Ph.D., Associate Professor of Science Education and Instructional Technology, Xavier University - Joseph South, Ph.D., Chief Innovation Officer, ISTE + ASCD - Adam Lockwood, Ph.D., Associate Professor of School Psychology, Kent State University - Terrence Sejnowski, Ph.D., Author, "ChatGPT and the Future of AI" - Anna Huntsman, Reporter, Ideastream Public Media - Jeff St. Clair, Midday Host, Ideastream Public Media

Commentary by Dr.  Jian'an Wang.

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow MysterySpecialGuest, Lehne zum Lümmeln, Dimmen aus der Ferne HS Workshops Workshops HS Workshop-Newsletter Statt Werbung DANKE an alle Spender HSFeedback #hshi von Volker: Nordfoto.de für gute Filmpreise #hshi von Anonym zur digital independence: Wollt ihr mal von Slack weg? #hsfeedback von Rolf: … „#929 – Milchtütenkonfetti“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Wir machen das Limit nicht, alles abschaffen, schwerkranke Nachbarin, Hof vom Schnee freiräumen HS Workshops Workshops HS Workshop-Newsletter Statt Werbung DANKE an alle Spender HSFeedback von Rolf: Feedback zum Gewinnerbild aus #927 von Arne: Mein Lieblingsbild 2025 von Jörg: Könnt ihr den … „#928 – Ich schlag ins Horn“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

Senior Scientist Fedor Galkin from Insilico Medicine in Abu Dhabi, UAE, joins Dr. Evgeniy Galimov to discuss a research paper he co-authored in Volume 17, Issue 8 of Aging-US, titled “AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging.” DOI - https://doi.org/10.18632/aging.206295 Corresponding author - Alex Zhavoronkov - alex@insilico.com Video interview - https://www.youtube.com/watch?v=PV6DyIV7X7U Abstract video - https://www.youtube.com/watch?v=24lX2lHbt7o Longevity & Aging Series - https://www.aging-us.com/longevity Abstract Idiopathic pulmonary fibrosis (IPF) is a condition predominantly affecting the elderly and leading to a decline in lung function. Our study investigates the aging-related mechanisms in IPF using artificial intelligence (AI) approaches. We developed a pathway-aware proteomic aging clock using UK Biobank data and applied it alongside a specialized version of Precious3GPT (ipf-P3GPT) to demonstrate an AI-driven mode of IPF research. The aging clock shows great performance in cross-validation (R2=0.84) and its utility is validated in an independent dataset to show that severe cases of COVID-19 are associated with an increased aging rate. Computational analysis using ipf-P3GPT revealed distinct but overlapping molecular signatures between aging and IPF, suggesting that IPF represents a dysregulation rather than mere acceleration of normal aging processes. Our findings establish novel connections between aging biology and IPF pathogenesis while demonstrating the potential of AI-guided approaches in therapeutic development for age-related diseases. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206295 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, IPF, generative AI, transformer, proteomics To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ YouTube - https://www.youtube.com/@Aging-US Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

How well flu vaccines protect public health Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Lauren Meyers explains what the 2022-2023 influenza season taught us about the effectiveness of flu vaccines. In this episode, we cover: •[00:00] Introduction •[01:16] Computational epidemiologist Lauren Meyers introduces the health and hospitalization burden of seasonal influenza. •[01:47] She defines vaccine effectiveness. •[02:37] Meyers describes the features of the 2022-2023 flu season. •[04:05] She describes how the researchers estimated the hospitalizations prevented by vaccination. •[05:11] Meyers tells how vaccination of young adults protected adults over 65 years of age. •[06:56] She describes the takeaways of the study for future flu seasons. •[08:08] Meyers lists the caveats and limitations of the study. •[09:49] Conclusion. About Our Guest: Lauren Meyers Professor University of Texas at Austin View related content here: https://www.pnas.org/doi/abs/10.1073/pnas.2505175122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Unterseite, Und sie ritten gemeinsam in den Sonnenuntergang, Mac Update HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Gebrauchsanleitung: Online-Workshop Statt Werbung DANKE an alle Spender … „#927 – Stell dir vor, da kommt ein Photon an“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

In episode 38, Thibault Schrepel talks to Alvin Koh, Chief Executive of the Competition and Consumer Commission of Singapore (CCS).They discuss the creation of the Data and Digital division and the operational role of instruments such as the Complaint Analytics Tool and the AI Verify Toolkit in investigative prioritization and compliance assessment. They also explore the application of computational methods in major enforcement initiatives, including the Grab–Uber merger and the Price Transparency Guidelines, before considering the implications of these practices for the future of competition enforcement in Singapore and the ASEAN region.Follow the Stanford Computational Antitrust project at ⁠https://law.stanford.edu/computationalantitrust

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Telefon, Außenstudio HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender HSFeedback Von Wulff: Mein Lieblingsbild 25025 – Sandwich Harbour Linktipp … „#926 – Verschüsselt“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

Dissecting different parallel processing streams may help us understand the mechanisms underlying psychiatric symptoms, such as delusions, and unite human and animal research.

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Schließfächer, komische Bearbeitung, digitaler Boost, scheint Feiertag zu sein, Das Regal HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender HSFeedback … „#925 – Workshop im Ohr“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Noch kein Shownoter da HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender Themen Video-Tipp: Fotografie im Weißen Haus Rückblick auf … „#924 – Angrasen“ weiterlesen

Computational methods are increasingly used by competition law regulators worldwide. But what are these and can companies also take advantage? Todd Davies, PhD candidate in competition law at University College London, joins Matthew Hall and Anora Wang to discuss the issues raised by the use of computational antitrust. Listen to this episode to learn more about the pros and cons of adoption by regulators, new tools available to companies, possible responses by regulators and key takeaways for practitioners and companies. With special guest: Todd Davies, University College London Related Links: Todd Davies, The Dark Side of Computational Antitrust: When AI is Used to Evade the Law, Kluwer Competition Law Blog (October 28, 2025) Thibault Schrepel, Computational Antitrust: An Introduction and Research Agenda (January 15, 2021) Thibault Schrepel and Teodora Groza, Computational Antitrust Worldwide: Fourth Cross-Agency Report (June 18, 2025) Hosted by: Matthew Hall, McGuireWoods and Anora Wang, Arnold & Porter

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Giraffen, Pferde mit Mützen HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender #hshi / #hsnachtrag Von Anonym: Habt Ihr Tipps … „#923 – Lufttüddelchen“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Weihnachtsmärkte, Mandeln, Nachbarn, aus der Erinnerung HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender – speziell für Auphoniczeit von Alexandra und … „#922 – Drecksbatzen!“ weiterlesen

In episode 37, Teodora Groza and Thibault Schrepel talk to Nuno Cunha Rodrigues, President of the Portuguese Competition Authority since 2023. They discuss the tools developed by the agency, how its lawyers work with economists and computer scientists, and the future of the field. Follow the Stanford Computational Antitrust project at https://law.stanford.edu/computationalantitrust

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

Send us a textWhat if the biggest breakthrough in pathology AI isn't a new algorithm—but finally sharing the data we already have?In this episode, I'm joined by Jeroen van der Laak and Julie Boisclair from the IMI BigPicture consortium, a European public-private initiative building one of the world's largest digital pathology image repositories. The goal isn't to create a single AI model—but to enable thousands by making high-quality, legally compliant data accessible at scale.We unpack what it really takes to build a 3-million-slide repository across 44 partners, why GDPR and data-sharing agreements delayed progress by 18 months, and how sustainability, trust, and collaboration are just as critical as technology. This conversation is about the unglamorous—but essential—work of building infrastructure that will shape pathology AI for decades.⏱️ Highlights with Timestamps[00:00–01:40] Why BigPicture focuses on data—not algorithms[01:40–03:16] Scope of the project: 44 partners, 15–18 countries, 3M images[03:16–06:20] The 18-month delay caused by legal frameworks and GDPR[06:20–11:52] Extracting data from heterogeneous lab infrastructures[11:52–13:38] Current status: 115,000 slides uploaded and growing[13:38–18:39] Why LLMs and foundation models make curated data more valuable than ever[18:39–23:49] Industry collaboration and shared negotiating power[23:49–28:06] Data access models and governance after project independence[28:06–31:59] Sustainability plans and nonprofit foundation model[37:02–43:18] Tools developed: DICOMizer, artifact detection AI, image registration

Andrej Bauer has done his PhD at CMU under Dana Scott, and he stands right on the edge between mathematics and computer science. During our conversation it just feels that he can just go on in depth about any topic remotely related to Type Theory and Programming Languages. Andrej is the person who organized for the The Proof Assistants stack exchange. He has an incredible blog that's always a great resource to learn Type Theory and Programming Languages Theory. He also has an incredible series of summer school lectures on effect handlers. But more specifically today we talk about Constructivism, Dialectica, Effect Handlers and AI. I'm sure you guys are gonna love it! Links Andrej's Website Andrej's Blog

AI's growing influence in pharma is transforming traditional drug discovery timelines. In a new pharmaphorum podcast, web editor Nicole Raleigh speaks with Dr Alan Roth, CEO of Oxford Drug Design, about the use of AI to accelerate discovery of new treatments for cancer, infectious diseases, and cystic fibrosis. Roth discusses combining deep enzyme biology expertise with GenAI and targeting leucyl-tRNA synthetase. You can listen to episode 231 of the pharmaphorum podcast in the player below, download the episode to your computer, or find it - and subscribe to the rest of the series – on Apple Podcasts, Spotify, Overcast, Pocket Casts, Podbean, and pretty much wherever else you download your other podcasts from.

Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Guten Abend schreibt der youtube, aus der Badewanne podcasten, Nix HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender #hshi / #hsnachtrag … „#921 – Podcast mit Patina“ weiterlesen

Computational methods can predict stability issues before the lab. But how do you actually implement these approaches in your formulation workflow? From excipient selection to long-term stability prediction, in silico tools are transforming how biotech teams develop robust formulations while reducing costly trial-and-error cycles.In Part 2, Giuseppe Licari, Principal Scientist in Computational Structural Biology at Merck KGaA, returns to share practical implementation strategies for integrating computational methods into biologics formulation development. Giuseppe reveals how molecular dynamics simulations guide excipient selection, where current methods hit their limits, and how emerging AI capabilities are expanding what's possible in formulation prediction.Whether you're at a well-resourced pharma company or a lean startup, Giuseppe offers actionable guidance for leveraging computational tools to predict protein behavior, optimize formulations, and accelerate your development timeline.Topics covered:Predicting protein aggregation and excipient interactions before manufacturing (00:45)Using molecular dynamics to understand protein behavior over time and in different environments (03:03)The interplay between computational predictions and experimental stability studies (04:49)The limitations of current in silico methods for predicting long-term stability (05:08)Emerging use of AI and machine learning to predict protein properties and improve developability (06:36)Future possibilities: Generative AI for protein design and formulation prediction (08:06)Advice for small companies: leveraging software-as-a-service and external partners to access computational tools (09:55)The impact of increasing computational power on the field's evolution (11:12)Most important takeaway: being open and curious about new computational techniques in biotech formulation (12:08)Discover how to bridge computational predictions with experimental validation, navigate the current limitations of in silico stability forecasting, and position your organization to benefit from AI-driven formulation development, regardless of your resource constraints.Connect with Giuseppe Licari to continue the conversation and explore how computational approaches can solve your formulation challenges before you ever step into the lab.Connect with Giuseppe Licari:LinkedIn: www.linkedin.com/in/giuseppe-licariNext step:Need fast CMC guidance? → Get rapid CMC decision support hereSupport the show

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

Matthew Terrill is the Co-Founder and CEO of Operations at Innovet Pet Products. He created Chefpaw the first ever Pet Food Maker. Mohammed Abouelsoud he researched 40 years of neurostimulation literature, built a prototype in his apartment, & tested it on himself. Three weeks later, the intrusive thoughts returned—but this time, he pushed them away. That moment launched U: The Mind Company a technology that would go on to treat patients across Pakistan, Congo, Brazil, & the United States.Movie Reviews and More is broadcast live Tuesdays at 5PM PT on K4HD Radio - Hollywood Talk Radio (www.k4hd.com) part of Talk 4 Radio (www.talk4radio.com) on the Talk 4 Media Network (www.talk4media.com). Movie Reviews and More TV Show is viewed on Talk 4 TV (www.talk4tv.com).Movie Reviews and More Podcast is also available on Talk 4 Media (www.talk4media.com), Talk 4 Podcasting (www.talk4podcasting.com), iHeartRadio, Amazon Music, Pandora, Spotify, Audible, and over 100 other podcast outlets.

What if you could predict formulation failures before ever touching a pipette? Computational approaches are revolutionizing biologics development, replacing trial-and-error experimentation with predictive intelligence that catches stability issues early and accelerates your path from candidate selection to clinic.In this episode, David Brühlmann welcomes Giuseppe Licari, Principal Scientist in Computational Structural Biology at Merck KGaA. A chemist by training, Giuseppe transitioned from wet lab experimentation to the predictive power of in silico modeling. Today, he operates at the intersection of computational biology and CMC development, using digital tools to screen candidates for developability, predict formulation challenges, and de-risk development programs before committing resources to the lab.Discover how computational methods are transforming the way biotech companies approach developability assessment and formulation strategy:Why maximizing shelf life isn't always necessary in early development phases (02:56)The critical role of communication between computational and bench scientists (06:46)Core properties to assess for developability, including hydrophobicity, aggregation, charge, and immunogenicity (11:06)How accurate are in silico predictions, and where do they add the most value? (13:23)The limitations and strengths of machine learning and physics-based models in predicting protein behavior (15:19)The differences between developability, formulation development, and formulatability, and the value of early cross-functional collaboration (17:17)When to use platform formulations and when tailored approaches are needed for complex molecules (19:25)The advantages of using computational methods at any stage, especially for de-risking strategies (20:13)Listen in for practical strategies for integrating in silico predictions into your developability and CMC workflows, catching stability issues before the lab, and making smarter development decisions that save time, material, and money.Connect with Giuseppe Licari:LinkedIn: www.linkedin.com/in/giuseppe-licariNext step:Need fast CMC guidance? → Get rapid CMC decision support hereOne bad CDMO decision can cost you two years and your Series A. If you're navigating tech transfer, CDMO selection, or IND prep, let's talk before it gets expensive. Two slots open this month.Support the show

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Alte Aussagen. Pferdegeschwindigkeit HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender #hshi / #hsnachtrag Von Rico: Wieso kann man keine … „#920 – Ösen können sich lösen“ weiterlesen

What are the best competing theories of consciousness? Can we isolate where it arises and measure how complex it is? How do 5meo DMT mystical or non-separation experiences shift worldviews on consciousness?In this episode we have the very theme of the podcast's title to delve into, the quest to understand the nature of consciousness. So we discuss mind and self, and what kind of substrate you need to allow for subjective experience; we look at the various philosophical positions on the nature of consciousness and ways to move beyond the unwinnable argument around the hard problem; we talk about extended cognition and cellular cognition; how integrated information theory attempts to quantify consciousness; the origin of meaning; psychedelics and the implications of mystical experiences of non-separation; whether AI will ever become conscious; and the implications of plant intelligence and memory.There's only one person who can speak about such a wide range of topics this well, one of the most passionate consciousness researchers in the world for over 40 years, physicist and neuroscientist, Christof Koch. He's Chief Scientist at the BlueDot Foundation, and has authored and co-authored over 1000 scientific papers and 6 books, including “The Quest for Consciousness”, “Confessions of a Romantic Reductionst” and “Then I am myself the World”, which we'll be focussing on today. What we discuss:00:00 His migration from physics to neuroscience.06:10 “Take no one's word for it”.07:50 His long-term Francis Crick collaboration.10:00 The signatures, footprints and correlates of consciousness.17:50 The empirical approach to the philosophical ‘Hard problem'.21:00 Metaphysics isn't empirical.21:40 The issues along the spectrum from materialism to idealism.29:00 “The great divide of being” - quotidian vs dissociated states.33:15 Is the self an illusion?34:15 The difference between self consciousness and subjective experience.38:00 “Confessions of a romantic reductionist”.41:00 Meaning is not an empirical subject.44:30 Integrated information theory explained - existence as casual power.52:50 The placebo effect is consciousness causally influencing the world.01:00:00 Computational theories of consciousness.01:03:10 The connectome: an exact brain replica in a simulation.01:05:10 Extended cognition & the blurred boundaries between selves.01:09:30 Michael Levin: the hierarchy from cellular to collective cognition.01:13:50 ‘Then I am myself the world' Book.01:14:40 5meoDMT: His mystical & NDE experiences.01:21:40 Lowering of the DMN in non-self like experiences like flow, meditation, day-dreaming, or psychedelics.01:24:00 To be real, experiences must have causal power.01:27:25 Perspective shift after psychedelics.01:30:50 Plant consciousness, intelligence, communication & memory.References: www.christofkoch.comScientific PapersChristof Koch, “Then I Am Myself the World: What Consciousness Is and How to Expand It the world”.Christof Koch, “Consciousness: Confessions of a romantic reductionist.”

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

On this episode of the Donut of Destiny, hosts Sotirios Evangelou, MD, FSCCT and Nisha Hosadurg , MBBS speak with guest Alan Vainrib, MD on how computational fluid dynamics (CFD) is emerging as a powerful research tool for understanding blood-flow behavior in structural heart disease. Using CT/MRI-based models, CFD can simulate pressures, velocities, shear stress and even post-procedure hemodynamics — offering new possibilities for evaluating aortic stenosis, planning TAVR and guiding mitral, tricuspid and LAAO interventions.

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Präsendung, Küchenmöbel, Geräusch™ HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender #hshi / #hsnachtrag Eik: Gimp in Unternehmen Andreas: Zum … „#919 – BallaLeica“ weiterlesen

Stephen Wolfram answers questions from his viewers about business, innovation, and managing life as part of an unscripted livestream series, also available on YouTube here: https://wolfr.am/youtube-sw-business-qaTopics discussed: Innovation, live Demos and leadership - AI Bubble, automation and the future of work - Company building and management - Global technology and development - Computational curiosities and fun ideas

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

A Computational Account of Borderline Personality Disorder: Impaired Predictive Learning About Self and Others Through Bodily SimulationIn this episode, Dr. Jud Brewer, Dr. Sarah Fineberg, and Dr. Philip Corlett explore an innovative computational psychiatry model of borderline personality disorder (BPD). Social dysfunction is a core feature of BPD, and this study proposes that individuals with BPD struggle with predictive learning about self and others due to deficits in embodied simulation—using one's own bodily experiences to infer the mental states of others. The discussion covers how computational models can help explain emotional dysregulation, attachment disruptions, and the instability of interpersonal relationships in BPD, offering new insights into treatment approaches. Tune in to discover how neuroscience, machine learning, and psychiatry intersect to deepen our understanding of personality disorders.Full Reference:Fineberg, S. K., Steinfeld, M., Brewer, J. A., & Corlett, P. R. (2014). A computational account of borderline personality disorder: Impaired predictive learning about self and others through bodily simulation. Frontiers in Psychiatry, 5, 111. https://doi.org/10.3389/fpsyt.2014.00111Let's connect on Instagram

Hausmeisterei Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Kirchenglocken, Halloween HS Workshops Workshops JETZT ONLINE HS Workshop-Newsletter Bitte gebt Feedback, welcher Wochentag für den Online-Worshop am besten passt. Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender #hshi / … „#918 – Esel auf nen Stapel“ weiterlesen

Chris, Ade and Jeremiah explore the ways new technology can help you make fantastic photos.

New @greenpillnet pod out today! Kevin talks with Akseli Virtanen, co-founder of the Economic Space Agency (ECSA), along with co-authors Dick Bryan and Jorge Lopez, about their groundbreaking book Protocols for Post-Capitalist Expression. They explore how capital is itself a protocol, how post-capitalism can emerge through new economic grammars, and why distributed finance and programmable accounting could redefine value beyond markets and the state. If you've ever wondered how economics, coordination, and code might come together to create new forms of collective value, this episode is for you.

PREVIEW: Quantum Computing: The Next Frontier Guest: Brandon Weichert Brandon Weichert reports on quantum computing as the "next wave" and frontier of computational power. Google recently achieved a major breakthrough by successfully testing stable quantum communication. While AI currently dominates technological discourse, Weichert believes that within 10 to 20 years, AI must be paired with quantum technology to fulfill its transformative potential. Quantum computing represents the next evolutionary leap in information processing capabilities, capable of solving problems intractable for classical computers and fundamentally reshaping industries from pharmaceuticals to cryptography.