Podcast appearances and mentions of Paul F Glenn

Most of us want to live as long as possible.   It's a SURVIVAL INSTINCT that's hard-wired into our DNA. BUT IT'S NOT ENOUGH TO LIVE A LONG LIFE. OUR QUALITY OF LIFE MATTERS, TOO. Unlocking the secrets to a long, healthy life has CHALLENGED MANKIND since the dawn of medical science.  Those of you who know me, also know I've been fascinated by this subject for quite a while, too. That's why it's a great privilege to welcome back this week's guest, DR. DAVID SINCLAIR. He is a LEADING SCHOLAR and Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at HARVARD MEDICAL SCHOOL where he has been teaching aging biology and translational medicine for aging for the past 16 years.  More than that, he is also a foremost researcher best known for his work on UNDERSTANDING WHY WE AGE and HOW TO SLOW ITS EFFECTS.  Contemporary BLEEDING EDGE RESEARCH and scientific advancements have propelled us forward and not only UNLOCKED SECRETS TO LONGEVITY but have also created new questions and curiosities that continue to excite our BEST AND BRIGHTEST MINDS.  And few people on planet earth are as well versed or as educated on this subject as Dr. Sinclair. He lives in a world filled with deep examinations of hormesis, sirtuins, energy metabolism, biosynthesis, mTOR levels, reprogramming genes, mitochondria, learning and memory, time-restricted feeding and caloric restrictions, neurodegeneration, and cancer.   While many of you may AWESTRUCK by this area of science, you should also be EXCITED by Dr. Sinclair's research, because one day it will have a DIRECT IMPACT on you. This week, we're going to translate what that research means to you in practical terms…and it's coming sooner than you think! Dr. Sinclair covers a wide range of topics from red light therapy, to the effects of glucose on our bodies, hormone replacement, and the importance of being physically active, fasting, and not eating meat. We also touch on ALTERING DNA which holds the possibility of significantly extending life, and CURING HORRIFIC DISEASES like cancer, MS, Alzheimer's, Parkinsons, and many others.Our discussion isn't just about theories and research though. Dr. Sinclair has also got some HANDS-ON TIPS on what you can do to start to start feeling and looking younger right now. So, sit back, relax, and LEARN.   CLASS IS ABOUT TO BEGIN, and I guarantee, you won't want to miss it.

This episode is brought to you by Rupa Health, Athletic Greens, and Eight Sleep. Aging doesn't have to be a one-way street. Our diet and lifestyle patterns are fundamental to the quality of our health, and the way we age. In this episode, my guests and I explain how to support our health to help us live longer, and more vibrantly. Dr. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging, and how to slow its effects. Their focus is on studying sirtuins as well as metabolism, neurodegeneration, cancer, cellular reprogramming, and more. Mark Sisson is the founder of the popular daily health blog, Mark's Daily Apple, godfather to the Primal food and lifestyle movement, and New York Times bestselling author of The Keto Reset Diet and The Primal Blueprint. Mark launched Primal Kitchen, a real-food company that creates Primal/Paleo, keto, and Whole30-friendly kitchen staples. Dr. Gerald Lemole is a board-certified cardiothoracic surgeon and integrative physician. In 1968, he was a member of the surgical team that performed the first successful heart transplant in the United States. His books include After Cancer Care, The Healing Diet, An Integrative Approach to Cardiac Care, Facing Facial Pain, and Lymph & Longevity: The Untapped Secret to Health. Dr. Mehmet Oz has won ten Daytime Emmy® Awards for The Dr. Oz Show and is an Attending Physician at NY Presbyterian-Columbia Medical Center. Dr. Oz received his undergraduate degree from Harvard University and obtained a joint MD and MBA from the University of Pennsylvania School of Medicine and Wharton Business School. Dr. Oz is the proud author of eight New York Times bestsellers including his most recent, Food Can Fix It. Dr. Cindy Geyer received her bachelor of science and her doctor of medicine degrees, with honors, from the Ohio State University. She completed residency in internal medicine at Strong Memorial Hospital in Rochester, N.Y. and is triple board certified in internal medicine, integrative medicine and lifestyle medicine. Dr. Richard Isaacson serves as Director of the Center for Brain Health and Director of the Alzheimer's Prevention Clinic (APC) at Florida Atlantic University's Schmidt College of Medicine. He previously served as Director of the APC at the Weill Cornell Memory Disorders Program, Assistant Dean of Faculty Development, and Associate Professor of Neurology at Weill Cornell Medicine & NewYork-Presbyterian. This episode is brought to you by Rupa Health, Athletic Greens, and Eight Sleep. Rupa Health is a place for Functional Medicine practitioners to access more than 2,000 specialty lab tests from over 20 labs. You can check out a free live demo with a Q&A or create an account here. Right now when you purchase AG1 from Athletic Greens, you will receive 10 free travel packs with your first purchase here. Eight Sleep's Pod Pro mattress is so smart that it adjusts your temperature and also gives you individualized recommendations on how to sleep better the next night. Save $150 at checkout and get yours here. See acast.com/privacy for privacy and opt-out information.

David Andrew Sinclair, PhD is an Australian biologist and professor of genetics. He is also a co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and is known for his research on aging with a focus on epigenetics. Time Stamps: 0:35:27 Podcast begins with David Sinclair 0:36:25 Is when we eat more important than what we eat? 0:38:45 What is the connection between time restrictive eating and longevity? 0:43:54 What causes us to age? 0:45:46 Epigenetic change. 0:52:03 What causes DNA breaks? 0:55:28 What plant foods create DNA breaks? 0:57:13 PARP enzymes  1:00:46 Where does NAD come from? How do we make it? What enzymes use it? 1:04:50 NAD recycling pathway. 1:12:13 Sirtuins. 1:24:14 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins? 1:31:50 Does being in a ketogenic state increase NAD? 1:40:30 Xenohormesis and plant molecules. 1:45:50 Resveratrol trials. 1:51:55 mTOR. 1:57:25 David's thoughts on animal protein. 2:04:03 Meat consumption in relation to the environment and regenerative agriculture. 2:11:28 Where to find David Sinclair. David's info: https://genetics.med.harvard.edu/sinc... https://lifespanbook.com/ Instagram: @davidsinclairphd Twitter: @davidasinclair Sponsors: Heart & Soil: www.heartandsoil.co White Oak Pastures: www.Whiteoakpastures.com, use code: CarnivoreMD for 10% off your first order The Cold Plunge: TheColdPlunge.com, use code CarnivoreMD for $111 off your cold plunge Eight Sleep: https://www.eightsleep.com/carnivoremd use code “CARNIVOREMD” to save $150 Sacred Hunting: www.sacredhunting.com/Paul for $250 off your hunt

I am honored to share the first episode of the new podcast, Lifespan with Dr. David Sinclair.  Dr. Sinclair is a professor of genetics Harvard Medical School. He is also the co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research.  David is both a friend and a colleague, and I am delighted to have helped him in the creation of this new podcast. It will be an 8-episode series that provides a deep dive into the science behind why we age and the newest research on what we can do to slow, stop and even reverse aging.  While we have Episode 1 of the Lifespan podcast here, please be sure to navigate over to the Lifespan with Dr. David Sinclair podcast channel to subscribe. New episodes will come out every Wednesday for the next 8 weeks. I am certain that you will both enjoy it and learn from it. Show notes for this episode can be found on the Lifespan with Dr. David Sinclair podcast channel. More on that here: https://lifespanpodcast.com   

Welcome to Lifespan with Dr. David Sinclair. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. New episodes will be released every Wednesday morning of both January and February 2022. This podcast can also be found on YouTube: https://www.youtube.com/davidsinclairpodcast My goal in creating this podcast is to discuss the science behind why we age and to share the newest research on what we can do to slow, stop and even reverse aging. In doing so, I hope to help explain the science in an easy-to-understand manner and I hope to help all our listeners in their journey to be healthier at any stage of life. Upcoming episodes will cover: why aging is a disease, the impact of dietary choices, fasting and exercise on aging, how various supplements and prescription drugs can protect against aging, why cosmetic aging occurs and how to combat it, the benefits and advancements of biotracking, and the future of age reversal. Please subscribe, share with friends, leave a comment or review, and most of all, thank you for coming with us on this journey into the mechanisms of aging and exploration of the tools for living longer, healthier lives!

In this episode, I talk to world-renowned biologist David Sinclair about aging and longevity. David rejects the notion that the deterioration of health is a natural part of growing old and asserts that aging is a disease itself that we need to reverse. But how will a reset of our biological clocks affect our interactions, responses to adversity, morality, and how we live our lives? We discuss the ethical implications of limitless lifespans and also touch on the topics of death, evolution, genetics, medicine, and data tracking.BioDr. David Sinclair is a professor in the department of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and co-founder of the scientific journal Aging. He is best known for his work on understanding why we age and how to slow its effects. In addition to being a co-founder of several biotechnology companies, he's the author of the book Lifespan: Why We Age – and Why We Don't Have To. Dr. Sinclair was listed by TIME magazine as one of the “100 most influential people in the world”.Website: sinclair.hms.harvard.eduTwitter: @davidasinclair Topics00:02:26 David's “sticky beak” personality00:05:08 David's childhood and upbringing00:10:21 The torment of inevitable death 00:15:13 David's life purpose00:22:06 Intergenerational interactions 00:28:59 Aging is a disease we can reverse 00:32:20 Accelerating human evolution 00:36:24 The SIR2 gene and the NMN+ pill00:40:04 Reverse brain aging and Alzheimer's00:42:50 Gene therapy in pills00:48:45 Will we be happier with longer lifespans? 00:52:49 Inside Tracker00:55:31 The future of data tracking and medicine01:00:47 The Information Theory of Aging01:09:08 Is there a biological limit to our lifespans?01:14:21 Mental states can produce epigenetic changes01:20:39 David's future projects

On this week's episode of Mindset Mentor, Expert Series! Dr. David Sinclair, biologist, professor of genetics, and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, drops by to discuss the wonders of the body and his pivotal studies on the human aging process. See omnystudio.com/listener for privacy information.

Covid-19 has in many ways changed the way we view our health. We talked about this with David Sinclair, professor of genetics and co-director of the Paul F. Glenn Center for Biology of Ageing at Harvard Medical School.

In case you missed it, we are bringing back episodes from the archives all week, January 4 thru January 8th, in addition to our weekly episode.  This week we launched our 2021 Exercise and Wellness Trends, a guide to the Top 16 ideas, rituals, and routines you should be adding to your life in 2021! HINT: David Sinclair,PhD, explains a few of the key longevity supplements, Resveratrol, NMN and NR we can be taking as we age and why. This is a replay of MOTM EP # 80. David is also on the pod MOTM EP #102 where he sheds light on COVID, Immune System Building and more. David Sinclair, Ph.D., A.O., is a globally renowned biologist and leading world authority on genetics and longevity. If you haven’t already read his incredible eye opening New York Times Best Selling book Lifespan, you are going to be ordering it for sure after this conversation. His revolutionary theory and idea’s on aging and why we don’t have to, which he presents in his Information Theory of Aging and writes about in the book, is based upon his research and studies over the past twenty five years.  It is truly groundbreaking.  This book is going to change your life, the way you think about aging, and your overall approach to health and the future of your healthcare. David and Marni caught up at Harvard Medical School where he is a Professor of Genetics and Co-Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. On today’s episode David and Marni talk about the inspiration behind David's quest and path into science, genetics, epigenetics, and longevity, the hallmarks of aging, reversing the aging process and turning back your biological clock, activating  your vitality genes and pathways, and easy to implement ways you can do this through intermittent fasting, exercise, and cold exposure and more. You will discover the science and emerging technology behind his Information Theory of Aging, Come to understand boosting Mitochondria, increasing NAD levels, and activating Sirtuin’s, learn how to Live healthier and stay younger thanks to his roadmap for taking charge of your health and destiny. David  talks about his theory that aging is a disease and by reversing its effects, you can possibly prevent such as age related diabetes, heart disease, Altheimers, infertility and more. David Sinclair’s obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He is also the co-founder of several biotechnology companies and is on the boards of several others.  co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 25 awards and honors including being one of Time Magazine’s Top 100 most influential people in the world (in 2014) and Top 50 People in Healthcare (2018). We hope you enjoy. If you like what you here, leave us a review on Apple. Connect @Lifespan on Instagram, Twitter and Facebook @MarniOnTheMove Instagram, Facebook, or LinkedIn        

If you had the chance to slow down the aging process, would you take it? This sci-fi concept may sound like something from a Star Trek episode. But with new research coming to light, anti-aging fiction could very soon be a reality. Maybe it’s all in the genes.  WELCOME TO THE DARIN OLIEN SHOW. On this podcast, you’ll hear me, Darin Olien, “the superfood hunter,” have honest conversations with the extraordinary people that inspire me. I hope that through their knowledge and unique perspectives, they’ll inspire you, too. Although our ideas and approaches to life may differ, our ultimate goal is the same- to save the planet one conversation at a time. So, if you’re interested in expanding your view of the world by learning new perspectives on health, nutrition, and healing the planet, this podcast is for you. Dr. David Sinclair is trying to put a stopper in the aging process. In fact, he’s the one leading the charge. David is the Australian-born Harvard Medical School professor of genetics. He’s also co-director of the Paul F. Glenn Center for the Biology of Aging Research at Harvard Medical School.  On top of all that, he’s also a Professor and Head of the Aging Labs at UNSW, Sydney, and an honorary Professor at the University of Sydney. Like many pioneering scientists, he hasn’t been immune to controversy. But, if you Google his name, you’ll see a laundry list of accolades. Especially within the area he’s best known for is, which are genes and small molecules that delay aging. He is currently spearheading the research into gene function in the aging process, with a really heavy focus on the Sirtuin genes.  Dr. Sinclair and his team are also trying to lift the lid on exactly what roles resveratrol and NAD precursors play in the anti-aging process. Alongside this, David has published over a whopping 170 scientific papers, is a co-inventor on over 50 patents, and co-founded multiple biotech companies in the areas of aging and biodefense.  Oh yeah, and he’s the author of Lifespan: Why We Age and Why We Don’t Have To, which shot him to number 11 on the New York Times bestseller list in just over a week. One of David’s most recent claims to fame was his selection to be one of Time Magazine’s 100 Most Influential People In The World. Now that is impressive.  In this conversation, Dr. Sinclair and I get right into the fantastic family of proteins known as Sirtuins and their role in the aging process. We also look at how Intermittent Fasting could turn back the clock. We get into how it all started with yeast cells, and why David is so interested in the NMN molecule. Other great topics we cover: The role Sirtuin genes play and why they’re so bossy Epigenetics and why biological stress isn’t such a bad thing Intermittent fasting and what skipping a meal can do for your body What is Resveratrol and how does it affect the body? Why the NAD molecule is so vital for every living organism The Zombie cells that wreak havoc on your health What David is so excited about for the future of anti-aging science Epigenetic reprogramming and reversing the ticking clock inside us all David’s take on stem cells and how they contribute to the aging process When you should really start taking care of your body Links: David on Facebook David on Twitter David on Instagram – @davidsinclairphd David Sinclair Lab – Harvard Medical School Lifespan Website - Be sure to sign up for Dr. Sinclair’s Newsletter! Paper on Olive Oil and SIRT-1 Activation  Netflix’ Down To Earth’ Official Trailer Want amazing skin using all-natural wild-harvested ingredients? Get Caldera Lab’s “The Good” - Use code “DARIN” for 20% off your first order.   The Darin Olien Show is produced by the team at Must Amplify. If you’re looking to give a voice to your brand, and make sure that it’s heard by the right people, head to www.mustamplify.com/darin to see what Amplify can do for you.

What Are Zombie Cells? | This episode is brought to you by Perfect KetoWe used to think that aging is synonymous with decline but we’re now learning that this doesn’t necessarily have to be the case. We’re also learning that there are ways we can harness our body’s innate repair mechanisms to slow down, and even sometimes, reverse the aging process. One such way is to reduce the number of senescent--or zombie--cells that we have. So what are zombie cells, and how can we get rid of them? Dr. Hyman recently discussed this in his conversation with Dr. David Sinclair, Dave Asprey, and Max Lugavere.Dr. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging, and how to slow its effects. More specifically, their focus is on studying sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as metabolism, neurodegeneration, cancer, cellular reprogramming, and more. Among other awards, he was included in Time Magazine’s list of the “100 Most Influential People in the World” and Time's “Top 50 in Healthcare.”Dave Asprey is the founder and CEO of Bulletproof 360, creator of the global phenomenon Bulletproof Coffee, a two-time New York Times bestselling author, the host of the Webby award-winning podcast Bulletproof Radio, serial entrepreneur, and global change agent. By employing the principles of biohacking (a term added to the Merriam-Webster Dictionary in September of 2018 with Dave’s influence) Dave has lost over 100 pounds, upgraded his brain, learned to sleep more efficiently in less time, and become a more effective entrepreneur, husband, father, and overall human being. In this episode, he shares his top tips and tricks for being superhuman and living to be 180 or beyond. Max Lugavere is a filmmaker, health, and science journalist and the author of the New York Times bestselling book Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life. He is also the host of the #1 iTunes health podcast The Genius Life. Max’s sophomore book, The Genius Life: Heal Your Mind, Strengthen Your Body, and Become Extraordinary, is a lifestyle guide to living happily and healthily with proven, research-based lifestyle tactics, which we dig into more throughout this episode. This episode is brought to you by Perfect Keto. Right now, Perfect Keto is offering Doctor’s Farmacy listeners 20% off plus free shipping with the code DRMARK. Just go to perfectketo.com/drmark, and make sure you try their Nut Butters and Keto Cookies.Find Dr. Hyman’s full-length conversation with Dr. David Sinclair, “Death is Inevitable but Aging is Not” here: https://DrMarkHyman.lnk.to/DrDavidSinclairFind Dr. Hyman’s full-length conversation with Dave Asprey, “Can You Age Backwards?” here:https://DrMarkHyman.lnk.to/DaveAspreyFind Dr. Hyman’s full-length conversation with Max Lugavere, “How To Fix Your Brain And Live A Genius Life” here:https://DrMarkHyman.lnk.to/MaxLugavere See acast.com/privacy for privacy and opt-out information.

Connecticut Today with Paul Pacelli opened the week with a great interview with Dr. Nir Barzilai, founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging Research at Albert Einstein College of Medicine of Yeshiva University. He spoke to Paul about things that even older people can do in terms of activity and nutrition that can help fight the Coronavirus. Also we carried part of Governor Ned Lamont's meeting with the media.

In this special episode of Bulletproof Radio, microbiologist and geneticist David Sinclair, Ph.D., gives a thoroughly researched perspective on the coronavirus, plus concrete steps you can take and lifestyle changes you can make to potentially lower your own risk.We cover food, fasting and fitness. A range of supplements. The research behind and benefits of a vaccine, the red tape of regulation, availability of home test kits, and much more. David is a professor in the department of Genetics at Harvard Medical School and founding director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. He’s best known for his extensive research on lifespan extension and treatment of diseases for aging. He’s an award-winning researcher whose work on resveratrol, NAD, and reprogramming to reverse aging have been widely hailed as major scientific breakthroughs.“Before this [coronavirus] happened, it was pretty obvious to me as someone who was already working in a company that was detecting viruses that these things were going to attack,” David says.Listen on for an in-depth discussion of recent coronavirus research and the COVID-19 strain that’s making its way around the world. Enjoy the show!Get links, resources and show notes at Dave.Asprey/podcasts.Watch the Instagram live Q&A video of Dave and David Sinclair, Ph.D., on YouTube.

In this special episode of Bulletproof Radio, microbiologist and geneticist David Sinclair, Ph.D., gives a thoroughly researched perspective on the coronavirus, plus concrete steps you can take and lifestyle changes you can make to potentially lower your own risk.We cover food, fasting and fitness. A range of supplements. The research behind and benefits of a vaccine, the red tape of regulation, availability of home test kits, and much more. David is a professor in the department of Genetics at Harvard Medical School and founding director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. He’s best known for his extensive research on lifespan extension and treatment of diseases for aging. He’s an award-winning researcher whose work on resveratrol, NAD, and reprogramming to reverse aging have been widely hailed as major scientific breakthroughs.“Before this [coronavirus] happened, it was pretty obvious to me as someone who was already working in a company that was detecting viruses that these things were going to attack,” David says.Listen on for an in-depth discussion of recent coronavirus research and the COVID-19 strain that’s making its way around the world. Enjoy the show!Get links, resources and show notes at Dave.Asprey/podcasts.Watch the Instagram live Q&A video of Dave and David Sinclair, Ph.D., on YouTube.

Podcast Notes Key Takeaways (David’s Immunity-Boosting Protocol) Keep your vitamin D levels upIntermittent fastKeep your blood sugar levels low by avoiding sugary foodsQuercetin(500-600 mg, 1-2x a day)Research indicates quercetin inhibits viral replicationLiposomal vitamin C (500 mg/day)Alpha-lipoic acid (ALA) (0.5-1 g, 1-2x a day)Data indicates ALA is helpful in fighting viral infectionsZinc(40 mg/day)Read the full notes @ podcastnotes.orgIn this special episode of Bulletproof Radio, microbiologist and geneticist David Sinclair, Ph.D., gives a thoroughly researched perspective on the coronavirus, plus concrete steps you can take and lifestyle changes you can make to potentially lower your own risk.We cover food, fasting and fitness. A range of supplements. The research behind and benefits of a vaccine, the red tape of regulation, availability of home test kits, and much more. David is a professor in the department of Genetics at Harvard Medical School and founding director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. He’s best known for his extensive research on lifespan extension and treatment of diseases for aging. He’s an award-winning researcher whose work on resveratrol, NAD, and reprogramming to reverse aging have been widely hailed as major scientific breakthroughs.“Before this [coronavirus] happened, it was pretty obvious to me as someone who was already working in a company that was detecting viruses that these things were going to attack,” David says.Listen on for an in-depth discussion of recent coronavirus research and the COVID-19 strain that’s making its way around the world. Enjoy the show!Get links, resources and show notes at Dave.Asprey/podcasts.Watch the Instagram live Q&A video of Dave and David Sinclair, Ph.D., on YouTube.

Podcast Notes Key Takeaways (David’s Immunity-Boosting Protocol) Keep your vitamin D levels upIntermittent fastKeep your blood sugar levels low by avoiding sugary foodsQuercetin(500-600 mg, 1-2x a day)Research indicates quercetin inhibits viral replicationLiposomal vitamin C (500 mg/day)Alpha-lipoic acid (ALA) (0.5-1 g, 1-2x a day)Data indicates ALA is helpful in fighting viral infectionsZinc(40 mg/day)Read the full notes @ podcastnotes.orgIn this special episode of Bulletproof Radio, microbiologist and geneticist David Sinclair, Ph.D., gives a thoroughly researched perspective on the coronavirus, plus concrete steps you can take and lifestyle changes you can make to potentially lower your own risk.We cover food, fasting and fitness. A range of supplements. The research behind and benefits of a vaccine, the red tape of regulation, availability of home test kits, and much more. David is a professor in the department of Genetics at Harvard Medical School and founding director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. He’s best known for his extensive research on lifespan extension and treatment of diseases for aging. He’s an award-winning researcher whose work on resveratrol, NAD, and reprogramming to reverse aging have been widely hailed as major scientific breakthroughs.“Before this [coronavirus] happened, it was pretty obvious to me as someone who was already working in a company that was detecting viruses that these things were going to attack,” David says.Listen on for an in-depth discussion of recent coronavirus research and the COVID-19 strain that’s making its way around the world. Enjoy the show!Get links, resources and show notes at Dave.Asprey/podcasts.Watch the Instagram live Q&A video of Dave and David Sinclair, Ph.D., on YouTube.

“Your genes are not your destiny.”David Sinclair, PhDAging is inevitable. Everybody grows old. Everyone dies.We accept these statements as fact.But what if they're just stories based on history and our current understanding of biology?What if everything we think we know about aging is about to change?Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today.At the bleeding edge of such breakthroughs you will find David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.Returning for his second appearance on the podcast, David is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world.In addition, David is the author of Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To -- a New York Times bestseller that proposes a radical new theory of aging. As he writes: “Aging is a disease, and that disease is treatable.”Last year I convened my first conversation with David (RRP #436), a scintillating and science-heavy primer on all things human lifespan, aging and longevity. It was a runaway hit with the listeners -- and left me wanting to know more.So today we pick up where we last left off, diving deeper into the physiological mechanisms that contribute to biological degeneration. And we go further into the current state of research to better understand what contributes to aging and what can be done to counteract it.Call him a dreamer, but David believes living to 200+ is a plausible reality. If you could double your lifespan, how would this impact how you choose to live? What would it mean for the future of humanity? And for the ecological stability of the planet? The implications are profound.Equal parts philosophic and scientific, this conversation will forever change the way you think about why you age and what you can do about it. And it will leave you armed simple lifestyle practices you can deploy -- intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat -- that will help you live younger and healthier for longer.Brilliant and lovely, it’s an honor to once again share this man's wisdom with you today. So break out that pen and paper, because you're going to want to take notes on this one.The visually inclined can watch it all go down on YouTube. And as always, the audio version streams wild and free on Apple Podcasts and Spotify.I sincerely hope you enjoy the episode.Peace + Plants,Listen, Watch & Subscribe Apple Podcasts | YouTube | Spotify | Stitcher | Google PodcastsThanks to this week’s sponsorsOn Running: Born in the Swiss Alps, On Running is the world's fastest growing running brand. From their patented cushioning system to their gorgeous minimal design aesthetic, On has become my got to for all my trail and road running needs with gear that fits, performs and looks great. To learn more about On go to on-running.com/richroll, pick your favorite shoe or apparel piece, and run in it for 30 days after which you can keep ‘em or return ‘em for a full refund no questions asked - an amazing no risk deal.Squarespace: The easiest way to create a beautiful website, blog, or online store for you and your ideas. Save 10% at checkout when visit squarespace.com/richroll and use the offer code RICHROLL at checkout.Zip Recruiter: Search for jobs hiring in your area using ZipRecruiter’s job search engine – the best way to find a job. To find jobs hiring near you and apply with just 1 click, visit: ziprecruiter.com/richrollNote: One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".SHOW NOTESCheck out David's NYT bestseller: Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To*Connect With David: Website | Facebook | Twitter | Instagram | LinkedInLife Biosciences: Life BiosciencesPodcast Notes: David Sinclair on The Rich Roll PodcastHarvard Medical School: The Sinclair LabHarvard Medical School: Rewinding The ClockHarvard Magazine: Anti-Aging Approaches: David Sinclair's anti-aging scienceTIME Magazine: Is an Anti-Aging Pill on the Horizon?TIME Magazine: This Compound Can Reverse Aging in Mice. Will It Work in People?Longevity Facts: NMN and NAD Reverse Aging of Blood Vessels in New StudyInside Tracker: Q&A: How Harvard's David Sinclair Unlocked His Own Fountain of YouthSlate: Could A Pill Slow Aging? Geneticist David Sinclair Thinks SoNext big Future: Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for LongevityYouTube: (VIDEO) David Sinclair Slowing down Aging | My NMN JourneyTedMed: (VIDEO) "Can a pill a day help keep aging away?" | David Sinclair, PhDBook: Now We Are Six (Winnie-the-Pooh)* by A.A. MilneSupplement: M98 Micronized Resveratrol by Revgenetics*Related Podcasts You Might Enjoy:RRP #436: David Sinclair On Extending Human LifespanRRP #367: Fasting For Longevity With Valter Longo, Ph.D.RRP #139: How To Live To Be 100+ With Dan BuettnerRRP #209: Rhonda Patrick, PhD On Longevity, Epigenetics & Microbiome HealthThanks to Jason Camiolo for production, audio engineering and show notes; Margo Lubin and Blake Curtis for video, editing and graphics; portraits by Ali Rogers; and theme music by Ana Leimma.*Disclosure: Books and products denoted with an asterisk are hyperlinked to an affiliate program. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.for 1000s of delicious, customized plant-based recipes & so much more, check out our Plantpower Meal PlannerHOW CAN I SUPPORT THE PODCAST?Tell Your Friends & Share Online!Subscribe & Review: iTunes | Spotify | Stitcher | Soundcloud | Google PodcastsDonate: Check out our Patreon accountSupport The Sponsors: One of the best ways to support the podcast is to support our sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors". See acast.com/privacy for privacy and opt-out information.

Podcast Notes Key Takeaways Sirtuins are a class of proteins that have two jobs:1) Regulate gene expression2) Help repair DNA damageSirtuins need NAD+ to function properly. Without it, aging is accelerated.As we age, our NAD+ levels dropBy the time we’re 50, our NAD+ levels are about half what they were when we were 20You can boost NAD+ through precursor supplementation, exercise, fasting, and by exposing yourself to cold/heat stressYour genes aren’t your destiny“80% of our health in old age is due to our lifestyle and how we live; only 20% is genetic” – David SinclairThe best thing you can do to live longer: eat less oftenRead the full notes @ podcastnotes.org“Your genes are not your destiny.”David Sinclair, PhDAging is inevitable. Everybody grows old. Everyone dies.We accept these statements as fact.But what if they're just stories based on history and our current understanding of biology?What if everything we think we know about aging is about to change?Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today.At the bleeding edge of such breakthroughs you will find David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.Returning for his second appearance on the podcast, David is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world.In addition, David is the author of Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To -- a New York Times bestseller that proposes a radical new theory of aging. As he writes: “Aging is a disease, and that disease is treatable.”Last year I convened my first conversation with David (RRP #436), a scintillating and science-heavy primer on all things human lifespan, aging and longevity. It was a runaway hit with the listeners -- and left me wanting to know more.So today we pick up where we last left off, diving deeper into the physiological mechanisms that contribute to biological degeneration. And we go further into the current state of research to better understand what contributes to aging and what can be done to counteract it.Call him a dreamer, but David believes living to 200+ is a plausible reality. If you could double your lifespan, how would this impact how you choose to live? What would it mean for the future of humanity? And for the ecological stability of the planet? The implications are profound.Equal parts philosophic and scientific, this conversation will forever change the way you think about why you age and what you can do about it. And it will leave you armed simple lifestyle practices you can deploy -- intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat -- that will help you live younger and healthier for longer.Brilliant and lovely, it’s an honor to once again share this man's wisdom with you today. So break out that pen and paper, because you're going to want to take notes on this one.The visually inclined can watch it all go down on YouTube. And as always, the audio version streams wild and free on Apple Podcasts and Spotify.I sincerely hope you enjoy the episode.Peace + Plants,Listen, Watch & Subscribe Apple Podcasts | YouTube | Spotify | Stitcher | Google PodcastsThanks to this week’s sponsorsOn Running: Born in the Swiss Alps, On Running is the world's fastest growing running brand. From their patented cushioning system to their gorgeous minimal design aesthetic, On has become my got to for all my trail and road running needs with gear that fits, performs and looks great. To learn more about On go to on-running.com/richroll, pick your favorite shoe or apparel piece, and run in it for 30 days after which you can keep ‘em or return ‘em for a full refund no questions asked - an amazing no risk deal.Squarespace: The easiest way to create a beautiful website, blog, or online store for you and your ideas. Save 10% at checkout when visit squarespace.com/richroll and use the offer code RICHROLL at checkout.Zip Recruiter: Search for jobs hiring in your area using ZipRecruiter’s job search engine – the best way to find a job. To find jobs hiring near you and apply with just 1 click, visit: ziprecruiter.com/richrollNote: One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".SHOW NOTESCheck out David's NYT bestseller: Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To*Connect With David: Website | Facebook | Twitter | Instagram | LinkedInLife Biosciences: Life BiosciencesPodcast Notes: David Sinclair on The Rich Roll PodcastHarvard Medical School: The Sinclair LabHarvard Medical School: Rewinding The ClockHarvard Magazine: Anti-Aging Approaches: David Sinclair's anti-aging scienceTIME Magazine: Is an Anti-Aging Pill on the Horizon?TIME Magazine: This Compound Can Reverse Aging in Mice. Will It Work in People?Longevity Facts: NMN and NAD Reverse Aging of Blood Vessels in New StudyInside Tracker: Q&A: How Harvard's David Sinclair Unlocked His Own Fountain of YouthSlate: Could A Pill Slow Aging? Geneticist David Sinclair Thinks SoNext big Future: Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for LongevityYouTube: (VIDEO) David Sinclair Slowing down Aging | My NMN JourneyTedMed: (VIDEO) "Can a pill a day help keep aging away?" | David Sinclair, PhDBook: Now We Are Six (Winnie-the-Pooh)* by A.A. MilneSupplement: M98 Micronized Resveratrol by Revgenetics*Related Podcasts You Might Enjoy:RRP #436: David Sinclair On Extending Human LifespanRRP #367: Fasting For Longevity With Valter Longo, Ph.D.RRP #139: How To Live To Be 100+ With Dan BuettnerRRP #209: Rhonda Patrick, PhD On Longevity, Epigenetics & Microbiome HealthThanks to Jason Camiolo for production, audio engineering and show notes; Margo Lubin and Blake Curtis for video, editing and graphics; portraits by Ali Rogers; and theme music by Ana Leimma.*Disclosure: Books and products denoted with an asterisk are hyperlinked to an affiliate program. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.for 1000s of delicious, customized plant-based recipes & so much more, check out our Plantpower Meal PlannerHOW CAN I SUPPORT THE PODCAST?Tell Your Friends & Share Online!Subscribe & Review: iTunes | Spotify | Stitcher | Soundcloud | Google PodcastsDonate: Check out our Patreon accountSupport The Sponsors: One of the best ways to support the podcast is to support our sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors". See acast.com/privacy for privacy and opt-out information.

Podcast Notes Key Takeaways Sirtuins are a class of proteins that have two jobs:1) Regulate gene expression2) Help repair DNA damageSirtuins need NAD+ to function properly. Without it, aging is accelerated.As we age, our NAD+ levels dropBy the time we’re 50, our NAD+ levels are about half what they were when we were 20You can boost NAD+ through precursor supplementation, exercise, fasting, and by exposing yourself to cold/heat stressYour genes aren’t your destiny“80% of our health in old age is due to our lifestyle and how we live; only 20% is genetic” – David SinclairThe best thing you can do to live longer: eat less oftenRead the full notes @ podcastnotes.org“Your genes are not your destiny.”David Sinclair, PhDAging is inevitable. Everybody grows old. Everyone dies.We accept these statements as fact.But what if they're just stories based on history and our current understanding of biology?What if everything we think we know about aging is about to change?Across the globe, scientists are working on treatments and therapies that are designed to extend healthy human lifespans well beyond what we know today.At the bleeding edge of such breakthroughs you will find David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.Returning for his second appearance on the podcast, David is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world.In addition, David is the author of Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To -- a New York Times bestseller that proposes a radical new theory of aging. As he writes: “Aging is a disease, and that disease is treatable.”Last year I convened my first conversation with David (RRP #436), a scintillating and science-heavy primer on all things human lifespan, aging and longevity. It was a runaway hit with the listeners -- and left me wanting to know more.So today we pick up where we last left off, diving deeper into the physiological mechanisms that contribute to biological degeneration. And we go further into the current state of research to better understand what contributes to aging and what can be done to counteract it.Call him a dreamer, but David believes living to 200+ is a plausible reality. If you could double your lifespan, how would this impact how you choose to live? What would it mean for the future of humanity? And for the ecological stability of the planet? The implications are profound.Equal parts philosophic and scientific, this conversation will forever change the way you think about why you age and what you can do about it. And it will leave you armed simple lifestyle practices you can deploy -- intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat -- that will help you live younger and healthier for longer.Brilliant and lovely, it’s an honor to once again share this man's wisdom with you today. So break out that pen and paper, because you're going to want to take notes on this one.The visually inclined can watch it all go down on YouTube. And as always, the audio version streams wild and free on Apple Podcasts and Spotify.I sincerely hope you enjoy the episode.Peace + Plants,Listen, Watch & Subscribe Apple Podcasts | YouTube | Spotify | Stitcher | Google PodcastsThanks to this week’s sponsorsOn Running: Born in the Swiss Alps, On Running is the world's fastest growing running brand. From their patented cushioning system to their gorgeous minimal design aesthetic, On has become my got to for all my trail and road running needs with gear that fits, performs and looks great. To learn more about On go to on-running.com/richroll, pick your favorite shoe or apparel piece, and run in it for 30 days after which you can keep ‘em or return ‘em for a full refund no questions asked - an amazing no risk deal.Squarespace: The easiest way to create a beautiful website, blog, or online store for you and your ideas. Save 10% at checkout when visit squarespace.com/richroll and use the offer code RICHROLL at checkout.Zip Recruiter: Search for jobs hiring in your area using ZipRecruiter’s job search engine – the best way to find a job. To find jobs hiring near you and apply with just 1 click, visit: ziprecruiter.com/richrollNote: One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".SHOW NOTESCheck out David's NYT bestseller: Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To*Connect With David: Website | Facebook | Twitter | Instagram | LinkedInLife Biosciences: Life BiosciencesPodcast Notes: David Sinclair on The Rich Roll PodcastHarvard Medical School: The Sinclair LabHarvard Medical School: Rewinding The ClockHarvard Magazine: Anti-Aging Approaches: David Sinclair's anti-aging scienceTIME Magazine: Is an Anti-Aging Pill on the Horizon?TIME Magazine: This Compound Can Reverse Aging in Mice. Will It Work in People?Longevity Facts: NMN and NAD Reverse Aging of Blood Vessels in New StudyInside Tracker: Q&A: How Harvard's David Sinclair Unlocked His Own Fountain of YouthSlate: Could A Pill Slow Aging? Geneticist David Sinclair Thinks SoNext big Future: Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for LongevityYouTube: (VIDEO) David Sinclair Slowing down Aging | My NMN JourneyTedMed: (VIDEO) "Can a pill a day help keep aging away?" | David Sinclair, PhDBook: Now We Are Six (Winnie-the-Pooh)* by A.A. MilneSupplement: M98 Micronized Resveratrol by Revgenetics*Related Podcasts You Might Enjoy:RRP #436: David Sinclair On Extending Human LifespanRRP #367: Fasting For Longevity With Valter Longo, Ph.D.RRP #139: How To Live To Be 100+ With Dan BuettnerRRP #209: Rhonda Patrick, PhD On Longevity, Epigenetics & Microbiome HealthThanks to Jason Camiolo for production, audio engineering and show notes; Margo Lubin and Blake Curtis for video, editing and graphics; portraits by Ali Rogers; and theme music by Ana Leimma.*Disclosure: Books and products denoted with an asterisk are hyperlinked to an affiliate program. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.for 1000s of delicious, customized plant-based recipes & so much more, check out our Plantpower Meal PlannerHOW CAN I SUPPORT THE PODCAST?Tell Your Friends & Share Online!Subscribe & Review: iTunes | Spotify | Stitcher | Soundcloud | Google PodcastsDonate: Check out our Patreon accountSupport The Sponsors: One of the best ways to support the podcast is to support our sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors". See acast.com/privacy for privacy and opt-out information.

Aging is a disease.Everyone gets old. But did you ever think of the symptoms of aging as a disease that can be cured?I'd heard about Dr. David Sinclair and his ground-breaking longevity research, and I knew he would be a fascinating person to interview about this idea.We ended up going really deep into the science of why we age, how to reverse it, and what is actually in our control.David told stories he'd never shared before, and I kept asking questions because I was so interested in what he was telling me.David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018.In this conversation, we discussed all of my top questions on why we age, how much of it is reversible, and all of the ways I've heard to increase your longevity and health.David is a wealth of wisdom on all these topics, and he also shared some of the hardest times of his life, including watching his mother die of lung cancer and why that impacted his work so much.If you are committed to improving your health and living a long and healthy life, this conversation is a must-listen in Episode 904.Is it possible to reverse death? (7:42)What are the main ways to turn on the longevity genes? (9:30)How do you say no to all the food offers around you? (17:30)How did you get fascinated by longevity and anti-aging? (19:15)How did you recover from a major career setback? (37:06)What was the biggest lesson you learned from a year of being homeless? (49:28)How important are heat and cold therapy to anti-aging? (59:38)What is the ideal way to use fasting to improve your health? (1:05:42)How old do you think you’ll be able to live? (1:14:15)How much does inflammation play into the longevity of your life? (1:20:44)How our body’s built-in defenses against aging work (1:12)Why 3 meals a day is too much food for most people (10:09)The main benefits of a plant-based diet for longevity (13:13)Why it’s important to remember that there will always be another meal (15:10)Why death is so shocking to us even though it happens all the time (21:01)The molecule that has been proven to protect against a variety of diseases (29:34)The story that David has never told of how he was homeless after college (44:45)How cells lose their ability to stay young (55:32)Lewis’ experience doing a cold-exposure intensive in Poland with Wim Hof (1:08:45)Plus much more...If you enjoyed this episode, check out the video, show notes and more at http://www.lewishowes.com/904 and follow at instagram.com/lewishowes

David Sinclair, Ph.D., A.O., is a globally renowned biologist and leading world authority on genetics and longevity. If you haven’t already read his incredible eye opening New York Times Best Selling book Lifespan, you are going to be ordering it for sure after this conversation. His revolutionary theory and idea’s on aging and why we don’t have to, which he presents in his Information Theory of Aging and writes about in the book, is based upon his research and studies over the past twenty five years.  It is truly groundbreaking.  This book is going to change your life, the way you think about aging, and your overall approach to health and the future of your healthcare. David and Marni caught up at Harvard Medical School where he is a Professor of Genetics and Co-Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. On today’s episode David and Marni talk about the inspiration behind David's quest and path into science, genetics, epigenetics, and longevity, the hallmarks of aging, reversing the aging process and turning back your biological clock, activating  your vitality genes and pathways, and easy to implement ways you can do this through intermittent fasting, exercise, and cold exposure and more. You will discover the science and emerging technology behind his Information Theory of Aging, Come to understand boosting Mitochondria, increasing NAD levels, and activating Sirtuin’s, learn how to Live healthier and stay younger thanks to his roadmap for taking charge of your health and destiny. David  talks about his theory that aging is a disease and by reversing its effects, you can possibly prevent such as age related diabetes, heart disease, Altheimers, infertility and more. David Sinclair’s obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He is also the co-founder of several biotechnology companies and is on the boards of several others.  co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 25 awards and honors including being one of Time Magazine’s Top 100 most influential people in the world (in 2014) and Top 50 People in Healthcare (2018). We hope you enjoy. If you like what you here, leave us a review on Apple. Connect @Lifespan on Instagram, Twitter and Facebook @MarniOnTheMove Instagram, Facebook, or LinkedIn Shop our Offers, Deals, and Favorite Products + Brands ans from our new series Long Slow Distance all about mind altering endurance training and the prodicusts I use that fuel me for sucess from On, Nuuns Hydration, Sign up for our Newsletter, The Download for Marni on the Move updates, exclusive offers, invites to events, and exciting news!    

What an absolute phenomenal episode we have in-store for you today. Happy Monday, welcome back Freedom Pact Family! Today on the show, we are joined by the current rockstar in the field of genetics and anti-aging - Professor David Sinclair. David is a professor in the department of Genetics and is the co-director of the Paul F. Glenn Centre for the biology of ageing at Harvard Medical School. The primary concern of David’s work is that of ageing - why we age, how to slow it down, and how to reverse it’s effects. David’s work has been featured in 5 books, two documentary movies, 60 minutes, Morgan Freeman’s ‘’through the wormhole and various other media. David is the owner of over 35 patent’s, and has received more than 25 awards including: Time Magazine’s 100 most influential people in the world, The Australian commonwealth prize, the bio-innovator award, top 100 Australian innovators, the CSL prize and the Thompson prize. As you can see - this guy is a fucking big deal. The podcast David did with Joe Rogan, was recently at #2 worldwide, David’s also just released a fantastic book called ‘Lifespan: Why we age - and why we don’t have to which I read last week, and have already been applying to my own life. As you can guess, this episode is all around the science of ageing and the strategies we can use to prevent it. I highly recommend you listen to the full thing, it’s a mind-blowing conversation. So, before we jump into this.. Could I just ask you for a favour that would mean the world to me? We love delivering great content and interacting and helping anyone who reaches out to us. If you could leave us a rating and a review on iTunes it helps us so much to grow the show and to attract the best guests. Links: Lifespan: Why we age and why we don't have to: https://amzn.to/31ISa2w David's social media: @davidsinclairphd - IG / @davidasinclair - TW @freedompact - IG / @freedompactpod - TW Get in touch! Personal / Business queries: freedompact@gmail.com

This week’s conversation is with Dr. David Sinclair, a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging and how to slow its effects.More specifically, their focus is on studying sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as metabolism, neurodegeneration, cancer, cellular reprogramming, and more.David is the co-creator and co-chief editor of the journal Aging, has co-founded several biotechnology companies, and is an inventor on 35 patents.Among the honors and awards he’s received are his inclusion in Time Magazine’s list of the “100 Most Influential People in the World” and Time's “Top 50 in Healthcare”.In addition, David is the author of the new book, Lifespan: The Revolutionary Science of Why We Age — and Why We Don’t Have To.I wanted to speak with David because he’s pushing the boundaries of what we understand to be possible for humans – and if he’s successful it will change the world as we know it.----Please support our partners!We're able to keep growing and creating content for YOU because of their support. We believe in their mission and would appreciate you supporting them in return!!Head to https://www.findingmastery.net/partners for all links and codes to take advantage of deals from our partners.

In this episode of Bulletproof Radio,my guest is an Australian biologist best known for his research on lifespan extension and the treatment of diseases for aging.“I'm a scientist,” says David Sinclair, Ph.D., “and I'm trying to figure this stuff out before time runs out for all of us.”David is a professor in the department of Genetics at Harvard Medical School and also co-director of Harvard’s Paul F. Glenn Center for the Biology of Aging. He’s the co-creator and co-chief editor of the journal Aging, has co-founded several biotechnology companies, and is an inventor of nearly three dozen patents. Among the career honors and awards he’s received are his inclusion in Time Magazine’s list of the “100 Most Influential People in the World” in 2014 and “The Healthcare 50: Fifty People Transforming Healthcare in 2018.”For two decades, his research at The Sinclair Lab has consistently focused on understanding how and why human beings age and how to slow its effects. “We need to move to a world where we know much more about our bodies and what's going on so we can get ahead of the problems before they actually cause us to get diseases,” he says.David has introduced an exciting new longevity theory based on his own research and the top aging scientific breakthroughs known to date. In this conversation, you’ll learn what he’s discovered about aging—he’s “reprogramming cells to be young again”—and the exciting science behind his new book: "Lifespan: The Revolutionary Science of Why We Age — and Why We Don’t Have To.” Enjoy the show!

In this episode of Bulletproof Radio,my guest is an Australian biologist best known for his research on lifespan extension and the treatment of diseases for aging.“I'm a scientist,” says David Sinclair, Ph.D., “and I'm trying to figure this stuff out before time runs out for all of us.”David is a professor in the department of Genetics at Harvard Medical School and also co-director of Harvard’s Paul F. Glenn Center for the Biology of Aging. He’s the co-creator and co-chief editor of the journal Aging, has co-founded several biotechnology companies, and is an inventor of nearly three dozen patents. Among the career honors and awards he’s received are his inclusion in Time Magazine’s list of the “100 Most Influential People in the World” in 2014 and “The Healthcare 50: Fifty People Transforming Healthcare in 2018.”For two decades, his research at The Sinclair Lab has consistently focused on understanding how and why human beings age and how to slow its effects. “We need to move to a world where we know much more about our bodies and what's going on so we can get ahead of the problems before they actually cause us to get diseases,” he says.David has introduced an exciting new longevity theory based on his own research and the top aging scientific breakthroughs known to date. In this conversation, you’ll learn what he’s discovered about aging—he’s “reprogramming cells to be young again”—and the exciting science behind his new book: "Lifespan: The Revolutionary Science of Why We Age — and Why We Don’t Have To.” Enjoy the show!

Age is not the definitive factor it’s made out to be when it comes to our health. We can use our age as a baseline for tracking our health and longevity, but it isn’t stagnant. For example, certain types of testing can help us compare our biological age to our calendar age in order to tinker with our wellness routine and achieve the milestones we’re after. With the right steps, we can slow down and even sometimes reverse the aging process.When it comes to our biological age, or the measure of how well our body is actually functioning for whatever life stage we are in, there are many things that impact it. Diet, lifestyle patterns like exercise and sleep, and stress are all involved in forming our biological age, along with many other factors like blood sugar, inflammation, and genetics. This week on The Doctor’s Farmacy, I’m joined by Dr. David Sinclair to explore the topic of longevity and anti-aging and how he reduced his own internal age by more than 20 years. Dr. Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging, and how to slow its effects. This episode of The Doctor’s Farmacy is brought to you by ButcherBox. Now through September 29, 2019, new subscribers to ButcherBox will receive ground beef for life. When you sign up today, ButcherBox will send you 2lbs of 100% pasture-raised grass-fed, grass finished beef free in every box for the life of your subscription. Plus listeners will get an additional $20 off their first box. All you have to do is head over to ButcherBox.com/farmacy See acast.com/privacy for privacy and opt-out information.

David Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. His new book "Lifespan: Why We Age And Why We Don't Have To" is now available.

In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age - and Why We Don’t Have To. This conversation focuses on the biological mechanisms involved in what David terms the Information Theory of Aging which provides insights into the “clock” that determines our aging and to what degree it can be manipulated. Our discussion on aging of course leads us into interconnected topics of epigenetics, sirtuins, cellular senescence, as well as what compounds David is personally taking for his own longevity. Additionally, we discuss the most up to date information related to NAD and longevity by looking at the potential benefits (if any) of supplemental agents (NAD precursors, NR, NMR, etc.) that pose a promise of increasing NAD. We discuss: SIR genes and cellular identity [8:45]; Sirtuins regulate gene expression [14:30]; DNA is methylated at the deepest layer of the epigenome [17:45]; Methylation pattern and determining cellular age [20:15]; Cellular reprogramming [33:45]; Yamanaka factors to push cells "back in time”  [41:00]; Human cellular reprogramming viability [57:00]; Measuring the rate of aging [1:02:45]; Cellular reprogramming for longevity [1:14:45]; Compounds David takes for his own longevity [1:29:15] NAD precursors (NR, NMN) and pterostilbene [1:40:00]; The current field of sirtuin activators [2:03:15]; David’s artistic work [2:05:15] and; More. Learn more: https://peterattiamd.com/ Show notes page for this episode:https://peterattiamd.com/davidsinclair2/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

“Nothing matters except making the world a better place after you’ve been here.”David Sinclair, PhDEverybody grows old. Everyone dies.But is this scientific fact? Or is it merely a story based on history and our current understanding of biology?What if we instead consider aging as a disease? This begs the question: what is the cure?Welcome to the mind of David Sinclair, PhD, one of the world’s leading scientific authorities on longevity, aging and how to slow its effects.A professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, David obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. where, among other things, he co-discovered the cause of aging for yeast.The co-founder of several biotechnology companies, David is also co-founder and co-chief editor of the journal Aging. His work has been featured in a variety of books, documentaries, and media, including 60 Minutes, Nightline and NOVA. He is an inventor on 35 patents, has been lauded as one of the Top 100 Australian Innovators, and made TIME magazine’s list of the 100 most influential people in the world.In addition, David is the author of the forthcoming book, Lifespan: The Revolutionary Science of Why We Age — and Why We Don't Have To* which hits bookstores on Sept. 10 and is currently available for pre-order here*.This is an absolutely fascinating conversation on all things human lifespan, aging and longevity. We begin with the specific scientific mechanisms that contribute to biological degeneration. Then we dive deep into the hard science David and his peers are examining to better understand what contributes to aging and how to prevent it.According to David, the prospect of living to 200+ is not a pipe dream, but a very possible reality. If humans could indeed double lifespan, how would this change how you live? And what does this mean for the future of humanity?This conversation travels deep into the scientific weeds. Perfect for the geeks among us. But it's also grounded in practical takeaways for all of us — because David's work isn't just about extending lifespan. It's about learning how to live as vibrantly and energetically as possible for as long as possible.It’s an honor and a privilege this brilliant man’s pioneering work and wisdom with you today. Plus he's a lovely guy. If you enjoyed my episode with Dr. Valter Longo (RRP #367), a fellow brilliant warrior in the longevity space, then I’m fairly confident you’re going to love this one. So break out that pen and paper, because you're going to want to take notes on this one.I sincerely hope you enjoy the episode.Peace + Plants,Listen, Watch & SubscribeApple Podcasts | ... See acast.com/privacy for privacy and opt-out information.

David Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. https://genetics.med.harvard.edu/sinclair/people/sinclair.php