Podcasts about biologists

 "China, die Erste" mit Göttern auf Tour - von Uwe Kullnick(Hördauer 32. Min)Aus seinem Buch „Lachen, Leben, Sterben“ liest Uwe Kullnick, die Geschichte einer ersten Reise nach China, ins Land der Mitte, der Weisheit und der Möglichkeiten unter dem Motto: „Reisen ist auch eine Art Wahnsinn.“ Die achtzehn Erzählungen aus fünf Kontinenten zeigen Menschen und Schicksale, wie sie unterschiedlicher nicht sein können. Sie erzählen, was sich in einem Reisenden an Erlebnissen, Beobachtungen, Szenen, kleinen und kleinsten Splittern in bekannten und exotischen Ländern entzünden kann. Manchmal sind es schlimme, oft schöne Gedanken die hier literarische Gestalt annehmen. Immer sind sie ein Stück des Lebens mit seinem – Lachen – Leben und Sterben.Es liest der Autor.Uwe Kullnick ist Naturwissenschaftler mit Leib und Seele. Er arbeitete in der strategischen Unternehmensleitung und war Senior Manager eines internationalen Konzerns und zuständig für 150 Länder. Seine akademischen Schwerpunkte als Dr. rer. nat. sind Biologie (Zoologie), Neurophysiologie und Sexualpsychologie. Manchmal ist er ein kompromissloser Biologist, wenn ihm jemand erzählen will, wie essenziell der Erhalt einer bestimmten Froschart ist, oder er ist analytisch bis zum Bersten seiner Diskussionspartner und ihm ist obendrein nichts Sexuelles zu fremd, um ihn noch staunen zu lassen. Heute ist er freier Autor und publiziert, Bücher, Hörbücher, Essays, Erzählungen, Kurzgeschichten, Podcasts. Uwe Kullnick ist Gründer und Intendant des Literatur Radio Hörbahn und der Histothek.

In this conversation, Buddy and Kolby discuss the evolving role of houndsmen in wildlife conservation, particularly in relation to mountain lions. They explore the importance of hounds in scientific studies, the changing perception of houndsmen within the professional community, and the challenges they face from anti-hunting advocates. The discussion emphasizes the need for houndsmen to engage with biologists and conservationists to improve their image and contribute positively to wildlife management efforts. In this conversation, Kolby Morehead and Buddy discuss various aspects of hunting, including the negative impact of poaching on the perception of houndsmen, the emotional narratives used by anti-hunting advocates, and the importance of building and tuning custom rifles. They also delve into the pressures of competitive shooting, the significance of learning through experience, and the fundamentals of shooting. The discussion highlights the benefits of suppressed shooting and the evolving nature of hunting practices.We would like to thank those who support this podcast.  Special thanks to Alpha Dog Nutrition and Double U Hunting Supply for sponsoring this episode.  Want to learn more about Alpha Dog Nutrition? Check out the links below https://www.dusupply.com/alphadog www.dusupply.com https://alphadognutrition.com/   https://www.youtube.com/@DoubleUHuntingSupply/podcasts

biologist #NDGF Doug Leier Outdoors Live April 18, 2025https://www.facebook.com/790kfgo: https://www.facebook.com/790kfgoSee omnystudio.com/listener for privacy information.

Starting a beauty brand is one thing – scaling it internationally is another challenge entirely. In this episode of Green Beauty Conversations, Lorraine Dallmeier – Chartered Environmentalist, Biologist, and CEO of Formula Botanica – is joined by Karmen Novak, founder of Flower and Spice, who shares how she turned her passion for botanical skincare into a thriving global brand. What began as a kitchen experiment quickly evolved into an international business. Karmen shares how she tackled the challenges of distribution, investment, and branding, all while expanding into one of the world's most competitive beauty markets – China.   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram  

This hour, Ian Hoch speaks with Jon Copley, a marine biologist and Professor of Ocean Exploration at the University of Southampton in the UK, about a colossal squid that was caught on tape for the first time in history!

Professor Carl Jones is a conservation biologist who is best known for saving the Mauritius kestrel from extinction. He is the scientific director of Mauritian Wildlife Foundation, chief scientist at Durrell Wildlife Conservation Trust and an honorary professor in ecology and conservation biology at the University of East Anglia.He was born in Carmarthen in Wales and was fascinated with animals from an early age, rearing rescued common kestrels, owls and hawks in his back garden. He studied biology at North-East London Polytechnic and, after learning about the plight of the Mauritius kestrel, he was determined to go out to the country to try to save the bird.He arrived in Mauritius in 1979 when there were only two known breeding pairs left in the wild. By the time he left in 1999 he'd established a captive breeding programme and today hundreds of Mauritius kestrels fly over the islands where he spent decades pioneering his, sometimes controversial, methods. Today the Mauritius kestrel is the national bird. He is also responsible for saving from extinction three species of reptiles, a fruit bat and several plants.He was appointed an MBE for his work in 2004 and in 2016 he won the prestigious Indianapolis Prize – the world's leading award for animal conservation.Carl lives in Carmarthen with his wife and two children and assorted animals including two Andean condors called Carlos and Baby. DISC ONE: Prokofiev: Peter and the Wolf Opus 67 - The London Symphony Orchestra, conducted by Sir Adrian Boult DISC TWO: Under Milk Wood by Dylan Thomas. Narrated by Richard Burton and performed by Meredith Edwards, Gwenllian Owen and Gwenyth Petty DISC THREE: Sex & Drugs & Rock & Roll - Ian Dury DISC FOUR: La Rivière Noire - John Kenneth Nelson DISC FIVE: Asimbonanga - Johnny Clegg & Savuka DISC SIX: Sega lakordeon – Rene oule bwar mwa - La Troupe de l'Union DISC SEVEN: Londonderry Air - Beatrice Harrison DISC EIGHT: Clear Sky - Catrin FinchBOOK CHOICE: The Collected Works of Dylan Thomas LUXURY ITEM: Binoculars CASTAWAY'S FAVOURITE: Asimbonanga - Johnny Clegg & Savuka Presenter Lauren Laverne Producer Paula McGinley

Della Fetzer is a biologist and entrepreneur. Her company, Rebel Cultures, partners with foresters, farmers, conservationists, greenhouses, and universities to develop low-cost and biodiversity-conscious propagation solutions for seed-scarce plants, and plants that can't be efficiently propagated from seed by using new approaches to tissue culture.

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Brandon Butler and Nathan “Shags” McLeod sit down with Minnesota DNR's fish biologist, Scott Mackenthun.In this episode, we explore the state of Minnesota's legendary waters, from the 10,000 lakes to the vast Boundary Waters and beyond. We dive into conservation efforts, the health of the fish populations, and what the future holds for Minnesota's iconic lakes and rivers. But it's not all science—Shags takes us on a personal journey, sharing stories from his basketball days in the Twin Cities, his fishing adventures with Shags Fishing Experience, and unforgettable trips to Ballard's Resort. We also hear about Brandon's childhood vacations fishing in Minnesota and his recent return to the Boundary Waters, all while weaving in a deep passion for both hunting and fishing. It's a conversation that blends conservation, outdoor adventure, and a love for Minnesota's natural beauty, with plenty of personal stories from the water and beyond.For more info:Shags Fishing ExperienceScott's Instagram Special thanks to:Living The Dream Outdoor PropertiesSuperior Foam Insulation LLCDoolittle TrailersScenic Rivers TaxidermyConnect with Driftwood Outdoors:FacebookInstagramYouTubeEmail:info@driftwoodoutdoors.com

We sat down with SD GFP Sr. Waterfowl biologist Rocco Murano and talked snow geese, avian influenza, canada geese on spring break, and duck jewelry! Tons of stuff we are betting you didnt know about our web footed friends.

Ellen Kamhi talks with Dr. Irene de Caso, a biologist who first specialized in neurobiology and then completed a master's of science and a doctorate in cognitive neuroscience and neuro-imaging from the University of York. A co-organizer of the 2020 Interdisciplinary Conference on Psychedelic Research and co-director of the Madrid Psychedelic Society, she lives in Madrid, Spain, where she works as a neuroscientific consultant and is studying to become a clinical psychologist. She is the author of "Psychedelics and Mental Health: Neuroscience and the Power of Psychoactives in Therapy."

Dr. Jessica Rose is an artist, musician, mathematician, professional surfer, biologist, science researcher & data analysis. Dr. Rose has a Post Doc in Biochemistry at Technion Institute of Technology, Post Doc in Molecular Biology at Hebrew University of Jerusalem, PhD in Computational Biology at Bar-Ilan University, Master's in Medicine (Immunology) at Memorial University of Newfoundland, and BSc in Applied Mathematics at Memorial University of Newfoundland.DR. JESSICA ROSE:Twitter: https://twitter.com/JesslovesMJKSubStack: https://jessicar.substack.com/YouTube: https://www.youtube.com/channel/UC0EhWf2Vswdg7DwKKKZ34ngTHE RIPPLE EFFECT PODCAST:WEBSITE: http://TheRippleEffectPodcast.comWebsite Host & Video Distributor: https://ContentSafe.co/SUPPORT:PATREON: https://www.patreon.com/TheRippleEffectPodcastPayPal: https://www.PayPal.com/paypalme/RvTheory6VENMO: https://venmo.com/code?user_id=3625073915201071418&created=1663262894MERCH Store: http://www.TheRippleEffectPodcastMerch.comMUSIC: https://music.apple.com/us/album/the-ripple-effect-ep/1057436436SPONSORS:OPUS A.I. Clip Creator: https://www.opus.pro/?via=RickyVarandasUniversity of Reason-Autonomy: https://www.universityofreason.com/a/2147825829/ouiRXFoL WATCH:RUMBLE: https://rumble.com/c/therippleeffectpodcastBANNED.VIDEO: https://banned.video/channel/the-ripple-effect-podcastOFFICIAL YOUTUBE: https://www.youtube.com/@TheRippleEffectPodcastOFFICIALYOUTUBE CLIPS CHANNEL: https://www.youtube.com/@RickyVarandasTikTok: https://www.tiktok.com/@ricky.varandasLISTEN:SPOTIFY: https://open.spotify.com/show/4lpFhHI6CqdZKW0QDyOicJiTUNES: http://apple.co/1xjWmlFPodOmatic: https://www.podomatic.com/podcasts/rvtheory6CONNECT:TeleGram: https://t.me/TREpodcastX: https://x.com/RvTheory6IG: https://www.instagram.com/rvtheory6/ FB: https://www.facebook.com/TheRippleEffectPodcast/THE UNION OF THE UNWANTED: https://linktr.ee/TheUnionOfTheUnwanted

On this exciting episode of Fishing the DMV, we're diving deep into one of Virginia's hottest bass fishing destinations — Smith Mountain Lake. Joining me is Dan Wilson, Fisheries Biologist with the Virginia Department of Wildlife Resources, to break down why this lake is quickly becoming a powerhouse in the bass fishing world.In early 2025 alone, multiple double-digit bass have been landed, including rumors of an 11-pound giant. With all this buzz, it's no surprise that Major League Fishing has set its sights on the lake for an upcoming Heavy Hitters event later this year.Dan gives us an exclusive look at:The 2024 fishery data and what it tells us about the lake's healthThe ongoing F1 Largemouth Bass stocking programHow the lake has evolved into a true big-bass destination

Send us a textThanks for tuning in to this episode of Follow The Brand! We hope you enjoyed learning about the latest marketing trends and strategies in Personal Branding, Business and Career Development, Financial Empowerment, Technology Innovation, and Executive Presence. To keep up with the latest insights and updates from us, be sure to follow us at 5starbdm.com. See you next time on Follow The Brand!

Download Your Free Ultimate Guide to Water Fasting to Heal Cancer and Chronic Illness  https://www.katiedeming.com/prolonged-water-fasting/Are sleep issues, brain fog, or unexplained symptoms affecting your quality of life?Dr. Katie Deming welcomes building biologist Shane Reilly to discuss the harmful health implications of electromagnetic fields (EMFs) in our homes. Shane shares his personal journey into this field after watching his mother's battle with brain cancer and experiencing unexplained health issues during his firefighter career.They unpack practical ways to create a healthier living environment without giving up modern conveniences. Shane explains how simple changes like turning off bedroom circuits at night, installing plastic pipe sections in water lines, and using ethernet instead of Wi-Fi can significantly reduce harmful exposures.Chapters:11:52 – Why EMFs in your home may be a problem24:26 – Is your wi-fi stronger than it should be?31:24 – A simple trick to reduce cell phone radiation38:36 – The invisible dangers of artificial lighting51:50 – Are your wellness devices harming your health?Learn about the significant increase in brain tumors among young adults over the past two decades and how our disconnection from natural light cycles might be contributing to various health problems.Listen and learn accessible solutions for creating what he calls a "campground experience" in your bedroom – that refreshed feeling you get after sleeping in nature. Connect with guest: https://optimaldwellingspaces.comSend us a text with your question (include your phone number)MORE FROM KATIE DEMING M.D. Download Your Free Ultimate Guide to Water Fasting to Heal Cancer and Chronic Illness https://www.katiedeming.com/prolonged-water-fasting/6 Pillars of Healing Cancer Workshop Series - Click Here to EnrollWork with Dr. Katie: www.katiedeming.comFollow Dr. Katie Deming on Instagram: https://www.instagram.com/katiedemingmd/ Take a Deeper Dive into Your Healing Journey: Dr. Katie Deming's Linkedin Here Please Support the Show Share this episode with a friend or family member Give a Review on Spotify Give a Review on Apple Podcast DISCLAIMER:The Born to Heal Podcast is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, c...

Questions have been raised over a three-week mission to locate and re-home three native skinks, at a cost of $85,000. It involved clearing vegetation along State Highway Three near New Plymouth - and releasing one copper skink and two gold striped geckos at Everett Park Scenic Reserve. Auckland University conservation biologist James Russell says the money spent was a fraction of the total costs of work on the highway. He explained New Zealand is extremely bio-diverse - and gold-striped geckos are incredibly rare. "It's just another species where we don't know what's happening - and if we don't look, it'll just disappear and be another blot on our record." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Is luxury beauty finally moving away from excess? In this episode of Green Beauty Conversations, Lorraine Dallmeier, Chartered Environmentalist, Biologist, and CEO of Formula Botanica, explores how minimalism is redefining premium beauty. Consumers are no longer impressed by overcomplicated routines and excessive packaging. Instead, they're demanding high-performance, multifunctional products that deliver results without the waste.  But is the beauty industry keeping up with this shift, or is it still clinging to outdated ideas of luxury? Find out in this episode!   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

In this one we continued our series where we take questions our listeners sent in and presented them to our resident biologists to get some answers for you. We jumped all over the place on this one, but we did our best to answer them the best that we could. Check it out! Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr Scarlett Smash & Dr Craken MacCraic go back in history to talk about the first marine biologist and their ground breaking discoveries more than 2000 years ago! Contact info@absolutelysmashingllc.com for more information about sponsoring MCHH episodes or having advertisements on the show Music credits By Jolly Shore Leave  "Al For Me Grog (Trad.)" HandsomeForrune-FE (Adapted Lyrics by Taran Christen : Musical Arrangement by K. Ryan Hart) Represented by Rebellious Entertainment Dr Scarlett Smash Instagram Dr Scarlett Smash TikTok  Dr Craken MacCraic Twitter Dr Craken MacCraic Instagram MCHH Instagram MCHH Facebook MCHH Twitter Dr Scarlett Smash Twitter  Dr Scarlett Smash YouTube

Can your mind actually control your body? How much of your consciousness is running the show of your life versus the unconscious part of your brain? Can you actually reprogram your mind? We're unleashing the power of consciousness matter and miracles and how you can CHANGE YOUR LIFE on this week's MBB! Cell biologist and epigenetics expert Dr. Bruce Lipton (author of “The Honeymoon Effect” & “Spontaneous Evolution") answers your deep questions and reveals groundbreaking insights into how our subconscious mind programming and how our biology of belief shapes our health, cells, and even our reality. Learn how quantum physics provides proof that we can change our physical world for the better, why early childhood programming is more crucial than we ever realized, and how love can heal negative programming. Discover the power of positive thinking, self-hypnosis, meditation and setting intentions to transform your body and mind - plus the science behind why the placebo effect really works. Dr. Lipton also uncovers why "we're already living in heaven", how exactly you can change your beliefs and put mind over matter, and how to raise conscious children. Don't miss his powerful and motivational explanation on the energy behind our thoughts and feelings and why we must stop overcomplicating them with words! Dr. Bruce Lipton's Books: https://www.brucelipton.com/books/ BialikBreakdown.comYouTube.com/mayimbialik

TRIGGER/CONTENT WARNING: weight, weight lossDr. Anthony and Dina dish about their decade-long friendship, evolutionary biology, and the future of health and nutrition sciences.Anthony J. Basile is a Registered Dietitian Nutritionist and Assistant Professor of Food & Nutrition at State University of New York (SUNY) Oneonta. Anthony holds a Bachelor of Science in Dietetics, Food, and Nutrition from City University of New York (CUNY), Lehman College, a Master of Science in Human Nutrition from Columbia University Irving Medical Center, as well as a Doctor of Philosophy in Evolutionary Biology from Arizona State University.Connect with Anthony on his website (https://www.ajbnutrition.com/) and social media platforms below: - Bluesky: https://bsky.app/profile/ajbnutrition.bsky.social - Instagram: https://www.instagram.com/ajb_nutrition/----DISCLAIMER: The purpose of this podcast is to entertain, educate, and inform, but it is not to be taken as medical advice. Please seek prompt, qualified medical care for any specific health issues and consult your physician or health practitioner before starting a new fitness regimen, herbal therapy, or other self-directed treatment.Join our mailing list to stay connected, stay informed, receive exclusive offers, and be a part of the DishWithDina community: https://forms.gle/VgDMkU8JDnBPywvh9If you enjoyed this podcast, please subscribe, leave a review, and share it with others! You can also submit listener feedback or request to be a guest on a future episode by completing this form: https://forms.gle/gxWd2Q3NU8akmFuv7

9:00 to 10:00Gregory J. OverackerThe Hunt for Brianna Maitland: The Relentless Pursuit of Answers to One of Vermont's Biggest Mysteries.By Gregory J. Overacker21st anniversary of Brianna Maitland's disappearance, which occurred on March 19, 2004, when she left work at the Black Lantern Inn in Montgomery, Vermont. 10:00 to 10:15Open show, Brad10:15 to 11:00Vermont Fish and wildlife, Rule making changes on deer herds and hunting rules. Public comment period and public engagmentAndrea ShortsleeveInterim Commissioner of Fish and WildlifeNick Fortin, Wildlife Biologist - Deer Project Leader, Rutland OfficeNick has been working with the department since 2015. He has a B.S. in wildlife ecology from University of Maine and an M.S. in Natural Resources/Wildlife from University of New Hampshire.Agency of Natural Resources(Sec. Julie Moore)

Guests:Dr Laura HayesDr Jessamyn FairfieldJoe Roman, Biologist at the University of Vermont

Dan Adams, Senior Executive with the Langdon Group, and Celeste Carlisle; Biologist with Return to Freedom Wild Horse, Sanctuary, Educational, and Advocacy Group; Chair of the National BLM Wildhorse Working Group; and Chair of National BLM & Forest Service Wild and Burro Advisory Board; join us to talk wild horses in the West.This free ranging discussion covers the incredibly complex and emotionally charged issue of wild horses. We talk about the environmental complexities, the regulatory complexities, and the political complexities informing solution making on this topic. Fascinating discussion.

This week, Tia takes us on her solo hiking adventure and we love how the first warm days bring everyone outside. We also ask the age-old question—why did every kid want to be a marine biologist? (Do we even know any marine biologists?!) Plus, Tia embraces her inner gnome, and we come to terms with our current fashion inspo: Adam Sandler core. Tune in for your weekly dose of chitchats with your virtual BFFS! CHAT WITH US: Tell us a funny story, ask for some advice from your virtual BFF, or just say hey... we'd love to hear from you - (414) 465-8275

Doug Leier NDGF Outreach Biologist part 2

Doug Leier NDGF Outreach Biologist part 1

What if your beauty routine was part of the problem – and the solution? In this episode of Green Beauty Conversations, host Lorraine Dallmeier, Chartered Environmentalist, Biologist, and CEO of Formula Botanica, speaks with Sira Naidu, co-founder of Disruptor London, a bold brand redefining beauty norms with innovative, multi-tasking solid formulations. Disruptor London is tackling overconsumption, plastic waste, and water scarcity while delivering high-performance hair and skincare solutions. Listen now to hear how Disruptor London is redefining sustainable beauty and why solid beauty could be the future of beauty.   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

This week: why is economic growth eluding Labour? ‘Growing pains' declares The Spectator's cover image this week, as our political editor Katy Balls, our new economics editor Michael Simmons, and George Osborne's former chief of staff Rupert Harrison analyse the fiscal problems facing the Chancellor. ‘Dominic Cummings may have left Whitehall,' write Katy and Michael, ‘but his spirit lives on.' ‘We are all Dom now,' according to one government figure. Keir Starmer's chief aide Morgan McSweeney has never met Cummings, but the pair share a diagnosis of Britain's failing economy. Identifying a problem is not, however, the same as solving it. As Rachel Reeves prepares her Spring Statement, ministers are bracing themselves for cuts in day-to-day spending as the public finances deteriorate. Is austerity back? Michael and Rupert joined the podcast to discuss further. (1:02) Next: survival of the fittest vs seduction by the hottest Biologist and Conservative peer Matt Ridley writes about the concept of sexual selection in the magazine this week, explaining that evolution might not just be driven by survival of the fittest but also by section by the hottest. This, he says, would explain some of nature's most colourful oddities, particularly within birds, as outlined in his new book Birds, Sex and Beauty. Charles Darwin proposed this as a later part of his evolutionary theory, but it caused a rift amongst his contemporaries – why is it a controversial concept? And could it be true for other species such as humans? Matt joined the podcast alongside David Puts, Professor of Anthropology and Psychology at Penn State University. (19:13) And finally: what makes historic murders so fascinating? Historian and author Hallie Rubenhold's new book, Story of a Murder: The Wives, the Mistress and Dr Crippen, retells the famous murder case from the perspective of the women involved. Lisa Hilton declares it an ‘intellectual adventure' in the lead book review in the magazine this week. But why do these cases continue to capture our imaginations, decades and even centuries later? And, whether as victims or as accomplices, what makes women such compelling subjects in historic cases like these? Hallie joined the podcast alongside the historian and broadcaster Alice Loxton, author of Eighteen: A History of Britain in 18 Young Lives. (30:40) Presented by William Moore and Lara Prendergast. Produced by Patrick Gibbons.

“Eventually, my dream would be to simulate a virtual cell.”—Demis HassabisThe aspiration to build the virtual cell is considered to be equivalent to a moonshot for digital biology. Recently, 42 leading life scientists published a paper in Cell on why this is so vital, and how it may ultimately be accomplished. This conversation is with 2 of the authors, Charlotte Bunne, now at EPFL and Steve Quake, a Professor at Stanford University, who heads up science at the Chan-Zuckerberg Initiative The audio (above) is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.TRANSCRIPT WITH LINKS TO AUDIO Eric Topol (00:06):Hello, it's Eric Topol with Ground Truths and we've got a really hot topic today, the virtual cell. And what I think is extraordinarily important futuristic paper that recently appeared in the journal Cell and the first author, Charlotte Bunne from EPFL, previously at Stanford's Computer Science. And Steve Quake, a young friend of mine for many years who heads up the Chan Zuckerberg Initiative (CZI) as well as a professor at Stanford. So welcome, Charlotte and Steve.Steve Quake (00:42):Thanks, Eric. It's great to be here.Charlotte Bunne:Thanks for having me.Eric Topol (00:45):Yeah. So you wrote this article that Charlotte, the first author, and Steve, one of the senior authors, appeared in Cell in December and it just grabbed me, “How to build the virtual cell with artificial intelligence: Priorities and opportunities.” It's the holy grail of biology. We're in this era of digital biology and as you point out in the paper, it's a convergence of what's happening in AI, which is just moving at a velocity that's just so extraordinary and what's happening in biology. So maybe we can start off by, you had some 42 authors that I assume they congregated for a conference or something or how did you get 42 people to agree to the words in this paper?Steve Quake (01:33):We did. We had a meeting at CZI to bring community members together from many different parts of the community, from computer science to bioinformatics, AI experts, biologists who don't trust any of this. We wanted to have some real contrarians in the mix as well and have them have a conversation together about is there an opportunity here? What's the shape of it? What's realistic to expect? And that was sort of the genesis of the article.Eric Topol (02:02):And Charlotte, how did you get to be drafting the paper?Charlotte Bunne (02:09):So I did my postdoc with Aviv Regev at Genentech and Jure Leskovec at CZI and Jure was part of the residency program of CZI. And so, this is how we got involved and you had also prior work with Steve on the universal cell embedding. So this is how everything got started.Eric Topol (02:29):And it's actually amazing because it's a who's who of people who work in life science, AI and digital biology and omics. I mean it's pretty darn impressive. So I thought I'd start off with a quote in the article because it kind of tells a story of where this could go. So the quote was in the paper, “AIVC (artificial intelligence virtual cell) has the potential to revolutionize the scientific process, leading to future breakthroughs in biomedical research, personalized medicine, drug discovery, cell engineering, and programmable biology.” That's a pretty big statement. So maybe we can just kind of toss that around a bit and maybe give it a little more thoughts and color as to what you were positing there.Steve Quake (03:19):Yeah, Charlotte, you want me to take the first shot at that? Okay. So Eric, it is a bold claim and we have a really bold ambition here. We view that over the course of a decade, AI is going to provide the ability to make a transformative computational tool for biology. Right now, cell biology is 90% experimental and 10% computational, roughly speaking. And you've got to do just all kinds of tedious, expensive, challenging lab work to get to the answer. And I don't think AI is going to replace that, but it can invert the ratio. So within 10 years I think we can get to biology being 90% computational and 10% experimental. And the goal of the virtual cell is to build a tool that'll do that.Eric Topol (04:09):And I think a lot of people may not understand why it is considered the holy grail because it is the fundamental unit of life and it's incredibly complex. It's not just all the things happening in the cell with atoms and molecules and organelles and everything inside, but then there's also the interactions the cell to other cells in the outside tissue and world. So I mean it's really quite extraordinary challenge that you've taken on here. And I guess there's some debate, do we have the right foundation? We're going to get into foundation models in a second. A good friend of mine and part of this whole I think process that you got together, Eran Segal from Israel, he said, “We're at this tipping point…All the stars are aligned, and we have all the different components: the data, the compute, the modeling.” And in the paper you describe how we have over the last couple of decades have so many different data sets that are rich that are global initiatives. But then there's also questions. Do we really have the data? I think Bo Wang especially asked about that. Maybe Charlotte, what are your thoughts about data deficiency? There's a lot of data, but do you really have what we need before we bring them all together for this kind of single model that will get us some to the virtual cell?Charlotte Bunne (05:41):So I think, I mean one core idea of building this AIVC is that we basically can leverage all experimental data that is overall collected. So this also goes back to the point Steve just made. So meaning that we basically can integrate across many different studies data because we have AI algorithms or the architectures that power such an AIVC are able to integrate basically data sets on many different scales. So we are going a bit away from this dogma. I'm designing one algorithm from one dataset to this idea of I have an architecture that can take in multiple dataset on multiple scales. So this will help us a bit in being somewhat efficient with the type of experiments that we need to make and the type of experiments we need to conduct. And again, what Steve just said, ultimately, we can very much steer which data sets we need to collect.Charlotte Bunne (06:34):Currently, of course we don't have all the data that is sufficient. I mean in particular, I think most of the tissues we have, they are healthy tissues. We don't have all the disease phenotypes that we would like to measure, having patient data is always a very tricky case. We have mostly non-interventional data, meaning we have very limited understanding of somehow the effect of different perturbations. Perturbations that happen on many different scales in many different environments. So we need to collect a lot here. I think the overall journey that we are going with is that we take the data that we have, we make clever decisions on the data that we will collect in the future, and we have this also self-improving entity that is aware of what it doesn't know. So we need to be able to understand how well can I predict something on this somewhat regime. If I cannot, then we should focus our data collection effort into this. So I think that's not a present state, but this will basically also guide the future collection.Eric Topol (07:41):Speaking of data, one of the things I think that's fascinating is we saw how AlphaFold2 really revolutionized predicting proteins. But remember that was based on this extraordinary resource that had been built, the Protein Data Bank that enabled that. And for the virtual cell there's no such thing as a protein data bank. It's so much more as you emphasize Charlotte, it's so much dynamic and these perturbations that are just all across the board as you emphasize. Now the human cell atlas, which currently some tens of millions, but going into a billion cells, we learned that it used to be 200 cell types. Now I guess it's well over 5,000 and that we have 37 trillion cells approximately in the average person adult's body is a formidable map that's being made now. And I guess the idea that you're advancing is that we used to, and this goes back to a statement you made earlier, Steve, everything we did in science was hypothesis driven. But if we could get computational model of the virtual cell, then we can have AI exploration of the whole field. Is that really the nuts of this?Steve Quake (09:06):Yes. A couple thoughts on that, maybe Theo Karaletsos, our lead AI person at CZI says machine learning is the formalism through which we understand high dimensional data and I think that's a very deep statement. And biological systems are intrinsically very high dimensional. You've got 20,000 genes in the human genome in these cell atlases. You're measuring all of them at the same time in each single cell. And there's a lot of structure in the relationships of their gene expression there that is just not evident to the human eye. And for example, CELL by GENE, our database that collects all the aggregates, all of the single cell transcriptomic data is now over a hundred million cells. And as you mentioned, we're seeing ways to increase that by an order of magnitude in the near future. The project that Jure Leskovec and I worked on together that Charlotte referenced earlier was like a first attempt to build a foundational model on that data to discover some of the correlations and structure that was there.Steve Quake (10:14):And so, with a subset, I think it was the 20 or 30 million cells, we built a large language model and began asking it, what do you understand about the structure of this data? And it kind of discovered lineage relationships without us teaching it. We trained on a matrix of numbers, no biological information there, and it learned a lot about the relationships between cell type and lineage. And that emerged from that high dimensional structure, which was super pleasing to us and really, I mean for me personally gave me the confidence to say this stuff is going to work out. There is a future for the virtual cell. It's not some made up thing. There is real substance there and this is worth investing an enormous amount of CZIs resources in going forward and trying to rally the community around as a project.Eric Topol (11:04):Well yeah, the premise here is that there is a language of life, and you just made a good case that there is if you can predict, if you can query, if you can generate like that. It is reminiscent of the famous Go game of Lee Sedol, that world champion and how the machine came up with a move (Move 37) many, many years ago that no human would've anticipated and I think that's what you're getting at. And the ability for inference and reason now to add to this. So Charlotte, one of the things of course is about, well there's two terms in here that are unfamiliar to many of the listeners or viewers of this podcast, universal representations (UR) and virtual instrument (VIs) that you make a pretty significant part of how you are going about this virtual cell model. So could you describe that and also the embeddings as part of the universal representation (UR) because I think embeddings, or these meaningful relationships are key to what Steve was just talking about.Charlotte Bunne (12:25):Yes. So in order to somewhat leverage very different modalities in order to leverage basically modalities that will take measurements across different scales, like the idea is that we have large, may it be transformer models that might be very different. If I have imaging data, I have a vision transformer, if I have a text data, I have large language models that are designed of course for DNA then they have a very wide context and so on and so forth. But the idea is somewhat that we have models that are connected through the scales of biology because those scales we know. We know which components are somewhat involved or in measurements that are happening upstream. So we have the somewhat interconnection or very large model that will be trained on many different data and we have this internal model representation that somewhat capture everything they've seen. And so, this is what we call those universal representation (UR) that will exist across the scales of biology.Charlotte Bunne (13:22):And what is great about AI, and so I think this is a bit like a history of AI in short is the ability to predict the last years, the ability to generate, we can generate new hypothesis, we can generate modalities that we are missing. We can potentially generate certain cellular state, molecular state have a certain property, but I think what's really coming is this ability to reason. So we see this in those very large language models, the ability to reason about a hypothesis, how we can test it. So this is what those instruments ultimately need to do. So we need to be able to simulate the change of a perturbation on a cellular phenotype. So on the internal representation, the universal representation of a cell state, we need to simulate the fact the mutation has downstream and how this would propagate in our representations upstream. And we need to build many different type of virtual instruments that allow us to basically design and build all those capabilities that ultimately the AI virtual cell needs to possess that will then allow us to reason, to generate hypothesis, to basically predict the next experiment to conduct to predict the outcome of a perturbation experiment to in silico design, cellular states, molecular states, things like that. And this is why we make the separation between internal representation as well as those instruments that operate on those representations.Eric Topol (14:47):Yeah, that's what I really liked is that you basically described the architecture, how you're going to do this. By putting these URs into the VIs, having a decoder and a manipulator and you basically got the idea if you can bring all these different integrations about which of course is pending. Now there are obviously many naysayers here that this is impossible. One of them is this guy, Philip Ball. I don't know if you read the language, How Life Works. Now he's a science journalist and he's a prolific writer. He says, “Comparing life to a machine, a robot, a computer, sells it short. Life is a cascade of processes, each with a distinct integrity and autonomy, the logic of which has no parallel outside the living world.” Is he right? There's no way to model this. It's silly, it's too complex.Steve Quake (15:50):We don't know, alright. And it's great that there's naysayers. If everyone agreed this was doable, would it be worth doing? I mean the whole point is to take risks and get out and do something really challenging in the frontier where you don't know the answer. If we knew that it was doable, I wouldn't be interested in doing it. So I personally am happy that there's not a consensus.Eric Topol (16:16):Well, I mean to capture people's imagination here, if you're successful and you marshal a global effort, I don't know who's going to pay for it because it's a lot of work coming here going forward. But if you can do it, the question here is right today we talk about, oh let's make an organoid so we can figure out how to treat this person's cancer or understand this person's rare disease or whatever. And instead of having to wait weeks for this culture and all the expense and whatnot, you could just do it in a computer and in silico and you have this virtual twin of a person's cells and their tissue and whatnot. So the opportunity here is, I don't know if people get, this is just extraordinary and quick and cheap if you can get there. And it's such a bold initiative idea, who will pay for this do you think?Steve Quake (17:08):Well, CZI is putting an enormous amount of resources into it and it's a major project for us. We have been laying the groundwork for it. We recently put together what I think is if not the largest, one of the largest GPU supercomputer clusters for nonprofit basic science research that came online at the end of last year. And in fact in December we put out an RFA for the scientific community to propose using it to build models. And so we're sharing that resource within the scientific community as I think you appreciate, one of the real challenges in the field has been access to compute resources and industry has it academia at a much lower level. We are able to be somewhere in between, not quite at the level of a private company but the tech company but at a level beyond what most universities are being able to do and we're trying to use that to drive the field forward. We're also planning on launching RFAs we this year to help drive this project forward and funding people globally on that. And we are building a substantial internal effort within CZI to help drive this project forward.Eric Topol (18:17):I think it has the looks of the human genome project, which at time as you know when it was originally launched that people thought, oh, this is impossible. And then look what happened. It got done. And now the sequence of genome is just a commodity, very relatively, very inexpensive compared to what it used to be.Steve Quake (18:36):I think a lot about those parallels. And I will say one thing, Philip Ball, I will concede him the point, the cells are very complicated. The genome project, I mean the sort of genius there was to turn it from a biology problem to a chemistry problem, there is a test tube with a chemical and it work out the structure of that chemical. And if you can do that, the problem is solved. I think what it means to have the virtual cell is much more complex and ambiguous in terms of defining what it's going to do and when you're done. And so, we have our work cut out for us there to try to do that. And that's why a little bit, I established our North Star and CZI for the next decade as understanding the mysteries of the cell and that word mystery is very important to me. I think the molecules, as you pointed out earlier are understood, genome sequenced, protein structure solved or predicted, we know a lot about the molecules. Those are if not solved problems, pretty close to being solved. And the real mystery is how do they work together to create life in the cell? And that's what we're trying to answer with this virtual cell project.Eric Topol (19:43):Yeah, I think another thing that of course is happening concurrently to add the likelihood that you'll be successful is we've never seen the foundation models coming out in life science as they have in recent weeks and months. Never. I mean, I have a paper in Science tomorrow coming out summarizing the progress about not just RNA, DNA, ligands. I mean the whole idea, AlphaFold3, but now Boltz and so many others. It's just amazing how fast the torrent of new foundation models. So Charlotte, what do you think accounts for this? This is unprecedented in life science to see foundation models coming out at this clip on evolution on, I mean you name it, design of every different molecule of life or of course in cells included in that. What do you think is going on here?Charlotte Bunne (20:47):So on the one hand, of course we benefit profits and inherit from all the tremendous efforts that have been made in the last decades on assembling those data sets that are very, very standardized. CELLxGENE is very somehow AI friendly, as you can say, it is somewhat a platform that is easy to feed into algorithms, but at the same time we actually also see really new building mechanisms, design principles of AI algorithms in itself. So I think we have understood that in order to really make progress, build those systems that work well, we need to build AI tools that are designed for biological data. So to give you an easy example, if I use a large language model on text, it's not going to work out of the box for DNA because we have different reading directions, different context lens and many, many, many, many more.Charlotte Bunne (21:40):And if I look at standard computer vision where we can say AI really excels and I'm applying standard computer vision, vision transformers on multiplex images, they're not going to work because normal computer vision architectures, they always expect the same three inputs, RGB, right? In multiplex images, I'm measuring up to 150 proteins potentially in a single experiment, but every study will measure different proteins. So I deal with many different scales like larger scales and I used to attention mechanisms that we have in usual computer vision. Transformers are not going to work anymore, they're not going to scale. And at the same time, I need to be completely flexible in whatever input combination of channel I'm just going to face in this experiment. So this is what we right now did for example, in our very first work, inheriting the design principle that we laid out in the paper AI virtual cell and then come up with new AI architectures that are dealing with these very special requirements that biological data have.Charlotte Bunne (22:46):So we have now a lot of computer scientists that work very, very closely have a very good understanding of biologists. Biologists that are getting much and much more into the computer science. So people who are fluent in both languages somewhat, that are able to now build models that are adopted and designed for biological data. And we don't just take basically computer vision architectures that work well on street scenes and try to apply them on biological data. So it's just a very different way of thinking about it, starting constructing basically specialized architectures, besides of course the tremendous data efforts that have happened in the past.Eric Topol (23:24):Yeah, and we're not even talking about just sequence because we've also got imaging which has gone through a revolution, be able to image subcellular without having to use any types of stains that would disrupt cells. That's another part of the deep learning era that came along. One thing I thought was fascinating in the paper in Cell you wrote, “For instance, the Short Read Archive of biological sequence data holds over 14 petabytes of information, which is 1,000 times larger than the dataset used to train ChatGPT.” I mean that's a lot of tokens, that's a lot of stuff, compute resources. It's almost like you're going to need a DeepSeek type of way to get this. I mean not that DeepSeek as its claim to be so much more economical, but there's a data challenge here in terms of working with that massive amount that is different than the human language. That is our language, wouldn't you say?Steve Quake (24:35):So Eric, that brings to mind one of my favorite quotes from Sydney Brenner who is such a wit. And in 2000 at the sort of early first flush of success in genomics, he said, biology is drowning in a sea of data and starving for knowledge. A very deep statement, right? And that's a little bit what the motivation was for putting the Short Read Archive statistic into the paper there. And again, for me, part of the value of this endeavor of creating a virtual cell is it's a tool to help us translate data into knowledge.Eric Topol (25:14):Yeah, well there's two, I think phenomenal figures in your Cell paper. The first one that kicks across the capabilities of the virtual cell and the second that compares the virtual cell to the real or the physical cell. And we'll link that with this in the transcript. And the other thing we'll link is there's a nice Atlantic article, “A Virtual Cell Is a ‘Holy Grail' of Science. It's Getting Closer.” That might not be quite close as next week or year, but it's getting close and that's good for people who are not well grounded in this because it's much more taken out of the technical realm. This is really exciting. I mean what you're onto here and what's interesting, Steve, since I've known you for so many years earlier in your career you really worked on omics that is being DNA and RNA and in recent times you've made this switch to cells. Is that just because you're trying to anticipate the field or tell us a little bit about your migration.Steve Quake (26:23):Yeah, so a big part of my career has been trying to develop new measurement technologies that'll provide insight into biology. And decades ago that was understanding molecules. Now it's understanding more complex biological things like cells and it was like a natural progression. I mean we built the sequencers, sequenced the genomes, done. And it was clear that people were just going to do that at scale then and create lots of data. Hopefully knowledge would get out of that. But for me as an academic, I never thought I'd be in the position I'm in now was put it that way. I just wanted to keep running a small research group. So I realized I would have to get out of the genome thing and find the next frontier and it became this intersection of microfluidics and genomics, which as you know, I spent a lot of time developing microfluidic tools to analyze cells and try to do single cell biology to understand their heterogeneity. And that through a winding path led me to all these cell atlases and to where we are now.Eric Topol (27:26):Well, we're fortunate for that and also with your work with CZI to help propel that forward and I think it sounds like we're going to need a lot of help to get this thing done. Now Charlotte, as a computer scientist now at EPFL, what are you going to do to keep working on this and what's your career advice for people in computer science who have an interest in digital biology?Charlotte Bunne (27:51):So I work in particular on the prospect of using this to build diagnostic tools and to make diagnostics in the clinic easier because ultimately we have somewhat limited capabilities in the hospital to run deep omics, but the idea of being able to somewhat map with a cheaper and lighter modality or somewhat diagnostic test into something much richer because a model has been seeing all those different data and can basically contextualize it. It's very interesting. We've seen all those pathology foundation models. If I can always run an H&E, but then decide when to run deeper diagnostics to have a better or more accurate prediction, that is very powerful and it's ultimately reducing the costs, but the precision that we have in hospitals. So my faculty position right now is co-located between the School of Life Sciences, School of Computer Science. So I have a dual affiliation and I'm affiliated to the hospitals to actually make this possible and as a career advice, I think don't be shy and stick to your discipline.Charlotte Bunne (28:56):I have a bachelor's in biology, but I never only did biology. I have a PhD in computer science, which you would think a bachelor in biology not necessarily qualifies you through. So I think this interdisciplinarity also requires you to be very fluent, very comfortable in reading many different styles of papers and publications because a publication in a computer science venue will be very, very different from the way we write in biology. So don't stick to your study program, but just be free in selecting whatever course gets you closer to the knowledge you need in order to do the research or whatever task you are building and working on.Eric Topol (29:39):Well, Charlotte, the way you're set up there with this coalescence of life science and computer science is so ideal and so unusual here in the US, so that's fantastic. That's what we need and that's really the underpinning of how you're going to get to the virtual cells, getting these two communities together. And Steve, likewise, you were an engineer and somehow you became one of the pioneers of digital biology way back before it had that term, this interdisciplinary, transdisciplinary. We need so much of that in order for you all to be successful, right?Steve Quake (30:20):Absolutely. I mean there's so much great discovery to be done on the boundary between fields. I trained as a physicist and kind of made my career this boundary between physics and biology and technology development and it's just sort of been a gift that keeps on giving. You've got a new way to measure something, you discover something new scientifically and it just all suggests new things to measure. It's very self-reinforcing.Eric Topol (30:50):Now, a couple of people who you know well have made some pretty big statements about this whole era of digital biology and I think the virtual cell is perhaps the biggest initiative of all the digital biology ongoing efforts, but Jensen Huang wrote, “for the first time in human history, biology has the opportunity to be engineering, not science.” And Demis Hassabis wrote or said, ‘we're seeing engineering science, you have to build the artifact of interest first, and then once you have it, you can use the scientific method to reduce it down and understand its components.' Well here there's a lot to do to understand its components and if we can do that, for example, right now as both of AI drug discoveries and high gear and there's umpteen numbers of companies working on it, but it doesn't account for the cell. I mean it basically is protein, protein ligand interactions. What if we had drug discovery that was cell based? Could you comment about that? Because that doesn't even exist right now.Steve Quake (32:02):Yeah, I mean I can say something first, Charlotte, if you've got thoughts, I'm curious to hear them. So I do think AI approaches are going to be very useful designing molecules. And so, from the perspective of designing new therapeutics, whether they're small molecules or antibodies, yeah, I mean there's a ton of investment in that area that is a near term fruit, perfect thing for venture people to invest in and there's opportunity there. There's been enough proof of principle. However, I do agree with you that if you want to really understand what happens when you drug a target, you're going to want to have some model of the cell and maybe not just the cell, but all the different cell types of the body to understand where toxicity will come from if you have on-target toxicity and whether you get efficacy on the thing you're trying to do.Steve Quake (32:55):And so, we really hope that people will use the virtual cell models we're going to build as part of the drug discovery development process, I agree with you in a little of a blind spot and we think if we make something useful, people will be using it. The other thing I'll say on that point is I'm very enthusiastic about the future of cellular therapies and one of our big bets at CZI has been starting the New York Biohub, which is aimed at really being very ambitious about establishing the engineering and scientific foundations of how to engineer completely, radically more powerful cellular therapies. And the virtual cell is going to help them do that, right? It's going to be essential for them to achieve that mission.Eric Topol (33:39):I think you're pointing out one of the most important things going on in medicine today is how we didn't anticipate that live cell therapy, engineered cells and ideally off the shelf or in vivo, not just having to take them out and work on them outside the body, is a revolution ongoing, and it's not just in cancer, it's in autoimmune diseases and many others. So it's part of the virtual cell need. We need this. One of the things that's a misnomer, I want you both to comment on, we keep talking about single cell, single cell. And there's a paper spatial multi-omics this week, five different single cell scales all integrated. It's great, but we don't get to single cell. We're basically looking at 50 cells, 100 cells. We're not doing single cell because we're not going deep enough. Is that just a matter of time when we actually are doing, and of course the more we do get down to the single or a few cells, the more insights we're going to get. Would you comment about that? Because we have all this literature on single cell comes out every day, but we're not really there yet.Steve Quake (34:53):Charlotte, do you want to take a first pass at that and then I can say something?Charlotte Bunne (34:56):Yes. So it depends. So I think if we look at certain spatial proteomics, we still have subcellular resolutions. So of course, we always measure many different cells, but we are able to somewhat get down to resolution where we can look at certain colocalization of proteins. This also goes back to the point just made before having this very good environment to study drugs. If I want to build a new drug, if I want to build a new protein, the idea of building this multiscale model allows us to actually simulate different, somehow binding changes and binding because we simulate the effect of a drug. Ultimately, the redouts we have they are subcellular. So of course, we often in the spatial biology, we often have a bit like methods that are rather coarse they have a spot that averages over certain some cells like hundreds of cells or few cells.Charlotte Bunne (35:50):But I think we also have more and more technologies that are zooming in that are subcellular where we can actually tag or have those probe-based methods that allow us to zoom in. There's microscopy of individual cells to really capture them in 3D. They are of course not very high throughput yet, but it gives us also an idea of the morphology and how ultimately morphology determine certain somehow cellular properties or cellular phenotype. So I think there's lots of progress also on the experimental and that ultimately will back feed into the AI virtual cell, those models that will be fed by those data. Similarly, looking at dynamics, right, looking at live imaging of individual cells of their morphological changes. Also, this ultimately is data that we'll need to get a better understanding of disease mechanisms, cellular phenotypes functions, perturbation responses.Eric Topol (36:47):Right. Yes, Steve, you can comment on that and the amazing progress that we have made with space and time, spatial temporal resolution, spatial omics over these years, but that we still could go deeper in terms of getting to individual cells, right?Steve Quake (37:06):So, what can we do with a single cell? I'd say we are very mature in our ability to amplify and sequence the genome of a single cell, amplify and sequence the transcriptome of a single cell. You can ask is one cell enough to make a biological conclusion? And maybe I think what you're referring to is people want to see replicates and so you can ask how many cells do you need to see to have confidence in any given biological conclusion, which is a reasonable thing. It's a statistical question in good science. I think I've been very impressed with how the mass spec people have been doing recently. I think they've finally cracked the ability to look at proteins from single cells and they can look at a couple thousand proteins. That was I think one of these Nature method of the year things at the end of last year and deep visual proteomics.Eric Topol (37:59):Deep visual proteomics, yes.Steve Quake (38:00):Yeah, they are over the hump. Yeah, they are over the hump with single cell measurements. Part of what's missing right now I think is the ability to reliably do all of that on the same cell. So this is what Charlotte was referring to be able to do sort of multi-modal measurements on single cells. That's kind of in its infancy and there's a few examples, but there's a lot more work to be done on that. And I think also the fact that these measurements are all destructive right now, and so you're losing the ability to look how the cells evolve over time. You've got to say this time point, I'm going to dissect this thing and look at a state and I don't get to see what happens further down the road. So that's another future I think measurement challenge to be addressed.Eric Topol (38:42):And I think I'm just trying to identify some of the multitude of challenges in this extraordinarily bold initiative because there are no shortage and that's good about it. It is given people lots of work to do to overcome, override some of these challenges. Now before we wrap up, besides the fact that you point out that all the work has to be done and be validated in real experiments, not just live in a virtual AI world, but you also comment about the safety and ethics of this work and assuming you're going to gradually get there and be successful. So could either or both of you comment about that because it's very thoughtful that you're thinking already about that.Steve Quake (41:10):As scientists and members of the larger community, we want to be careful and ensure that we're interacting with people who said policy in a way that ensures that these tools are being used to advance the cause of science and not do things that are detrimental to human health and are used in a way that respects patient privacy. And so, the ethics around how you use all this with respect to individuals is going to be important to be thoughtful about from the beginning. And I also think there's an ethical question around what it means to be publishing papers and you don't want people to be forging papers using data from the virtual cell without being clear about where that came from and pretending that it was a real experiment. So there's issues around those sorts of ethics as well that need to be considered.Eric Topol (42:07):And of those 40 some authors, do you around the world, do you have the sense that you all work together to achieve this goal? Is there kind of a global bonding here that's going to collaborate?Steve Quake (42:23):I think this effort is going to go way beyond those 40 authors. It's going to include a much larger set of people and I'm really excited to see that evolve with time.Eric Topol (42:31):Yeah, no, it's really quite extraordinary how you kick this thing off and the paper is the blueprint for something that we are all going to anticipate that could change a lot of science and medicine. I mean we saw, as you mentioned, Steve, how that deep visual proteomics (DVP) saved lives. It was what I wrote a spatial medicine, no longer spatial biology. And so, the way that this can change the future of medicine, I think a lot of people just have to have a little bit of imagination that once we get there with this AIVC, that there's a lot in store that's really quite exciting. Well, I think this has been an invigorating review of that paper and some of the issues surrounding it. I couldn't be more enthusiastic for your success and ultimately where this could take us. Did I miss anything during the discussion that we should touch on before we wrap up?Steve Quake (43:31):Not from my perspective. It was a pleasure as always Eric, and a fun discussion.Charlotte Bunne (43:38):Thanks so much.Eric Topol (43:39):Well thank you both and all the co-authors of this paper. We're going to be following this with the great interest, and I think for most people listening, they may not know that this is in store for the future. Someday we will get there. I think one of the things to point out right now is the models we have today that large language models based on transformer architecture, they're going to continue to evolve. We're already seeing so much in inference and ability for reasoning to be exploited and not asking for prompts with immediate answers, but waiting for days to get back. A lot more work from a lot more computing resources. But we're going to get models in the future to fold this together. I think that's one of the things that you've touched on the paper so that whatever we have today in concert with what you've laid out, AI is just going to keep getting better.Eric Topol (44:39):The biology that these foundation models are going to get broader and more compelling as to their use cases. So that's why I believe in this. I don't see this as a static situation right now. I just think that you're anticipating the future, and we will have better models to be able to integrate this massive amount of what some people would consider disparate data sources. So thank you both and all your colleagues for writing this paper. I don't know how you got the 42 authors to agree to it all, which is great, and it's just a beginning of something that's a new frontier. So thanks very much.Steve Quake (45:19):Thank you, Eric.**********************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access, with no ads..Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. 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Welcome to Part 2 of our deep dive on coal in Alberta, with a conversation with biologist and environmental scientist Lorne Fitch!Lorne has been following the impact of coal mining in Alberta for the last 50 years and for his work on conservation he has been part of three Alberta Emerald awards, an Alberta Order of the Bighorn Award, and a Canadian Environmental Gold Award, with additional recognition from The Wildlife Society, the Society for Range Management, the Alberta Society of Professional Biologists, the Western Association of Fish and Wildlife Agencies, and the Alberta Wilderness Association. Lorne lives in Lethbridge, Alberta.So while the UCP are certainly trying to paint a picture for Albertans that coal can and will be mined safely, Lornes research and experience tells a very different story! If you're able to support our legal defense fund to fight back against the $6 Million lawsuit against us by Sam Mraiche, the man who imported Vanch masks and the Turkish Tylenot as well as who hosted MLA's and Ministers in his skybox as he had business with the government...You can do that at www.savethebreakdownab.ca!As always, if you appreciate the kind of content that we're trying to produce here at The Breakdown, please consider signing up as a monthly supporter at our Patreon site at www.patreon.com/thebreakdownab and we can now accept e-transfers at info@thebreakdownab.ca!If you're listening to the audio version of our podcast, please consider leaving us a review and a rating, and don't forget to like and follow us on Bluesky, Facebook, Twitter, Instagram and Threads!

Kelly Warren is the Western Oregon regional Biologist for Ducks Unlimited. Kelly often works with local land owners to cooperatively design and develop thriving habitats for all wetland species. In this episode of Fin and Fire with Jeff Mishler we talk about the processes of teamwork required to transform acres into productive wildlife habitat.  We also share some duck hunting stories and a couple of hunting tips. 

Doug Leier NDGF Outreach Biologist part 1

Have you ever stopped to wonder about the story behind your beauty products and their ingredients? Most of us don't think twice when picking up a product off the shelf, but what if we did? In this episode of Green Beauty Conversations, Lorraine Dallmeier – Chartered Environmentalist, Biologist, and CEO of Formula Botanica – dives into the untold stories behind your beauty ingredients. Tune in now to hear why transparency and ethical supply chains matter, and how you can help set new standards for the beauty industry.   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

Wildlife conservation biologist Kaushiik Subramaniam has traveled the world studying human-wildlife interactions, from elephant populations in South Africa to whale shark tourism in the Maldives. As an award-winning photographer and filmmaker, he combines science with storytelling to raise awareness and drive conservation efforts. With experience working alongside organizations like the BBC, Kaush uses media as a powerful tool to bring critical conservation stories to life. His passion for wildlife and commitment to sharing its stories offer a unique perspective on the intersection of science, media, and environmental protection.Become a supporter of this podcast: https://www.spreaker.com/podcast/globetrotters-podcast--5023679/support.

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Guest: Chief Eric Parra on the Huntington Beach PD on the HBPD Awards/ Gov. Gavin Newsom on transgender athletes 'Issue of fairness'. // Brady Bunch and The Partridge Family Theme Song/ Retail Theft Bust as L.A. task force recovers $4M worth of goods from Target, Macy's, and more // Guest: Sandy Speers, Biologist and executive director of Friends of Big Bear Valley Hatched (Bald Eagles Jackie and Shadow welcome two new eaglets). 

Have you ever stopped to consider where the ingredients in your beauty products come from? Behind every bottle of oil or jar of cream lies a story – one that often goes untold. In this episode of Green Beauty Conversations, Lorraine Dallmeier – Chartered Environmentalist, Biologist, and CEO of Formula Botanica – is joined by Chloé Vallée, co-founder of Primegreen, a social enterprise transforming how the beauty industry sources its ingredients. Tune in now to learn about the social and environmental impact of sustainable farming for ingredients like moringa, the challenges and rewards of working with local growers, and how telling stories can inspire change across the beauty industry.   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

It was 50 years ago this March that science research in the U.S. took a landmark turn. Biologists know the significance of the historic Asilomar Conference, which gathered around 150 scientists in California. They had reached a turning point in research on DNA that would change the science world forever. Kate Adamala researches genetics and cell biology at the University of Minnesota. Her work to create artificial cells is a direct result of what scientists talked about at their conference 50 years ago. And she was lucky enough to be at the anniversary conference to talk about the state of biotechnology in California last week. Adamala is back in Minnesota and joined MPR News host Nina Moini to reflect on that experience.

In this episode of the Nine Finger Chronicles podcast, host Dan Johnson speaks with Patrick Wightman, a research scientist at the University of Georgia, about wild turkey research and conservation. They discuss the importance of habitat management, the impact of hunting on wildlife research, and the current state of wild turkey populations in North America. Wightman shares insights on the factors affecting turkey mortality, including habitat loss and predation, and emphasizes the role of both public and private landowners in conservation efforts. The conversation also touches on the challenges posed by federal funding cuts and the need for a broader understanding of wildlife management. In this conversation, Dan Johnson and Patrick Wightman discuss ongoing research at the University of Georgia focused on wild turkeys, including innovative technologies being used to study their behavior and population dynamics. They explore the importance of collaboration among researchers, the future of wild turkeys in North America, and the impact of habitat management on turkey populations. The discussion highlights the challenges and advancements in turkey research, emphasizing the role of technology and conservation efforts. Takeaways: Patrick Wightman has been studying wild turkeys for about 10 years. His research focuses on wildlife ecology and management. Hunting experience provides a unique perspective on turkey research. Federal funding cuts are impacting wildlife research projects. Private landowners play a crucial role in habitat management. Recent years have shown a stabilization in turkey populations. Habitat loss is a significant factor in turkey mortality. Early successional habitat is vital for poult survival. State agencies manage turkey populations at a broader scale. Predation is a concern but is linked to habitat availability. We're looking at disease prevalence across these studies. We're putting GPS backpacks on these turkeys. The idea was to get gobbling chronology. It's very difficult to manage for a species where you don't know how many are on the landscape. We're hoping to learn enough about individual gobbling behavior. We can train computer software to identify differences in individual signatures. We have to get the unit back in hand for audio files. Increasing the habitat can absolutely increase the number of turkeys. Almost half of male mortality is from avian predation at night. We need to make the habitat the best we can. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Nine Finger Chronicles podcast, host Dan Johnson speaks with Patrick Wightman, a research scientist at the University of Georgia, about wild turkey research and conservation. They discuss the importance of habitat management, the impact of hunting on wildlife research, and the current state of wild turkey populations in North America. Wightman shares insights on the factors affecting turkey mortality, including habitat loss and predation, and emphasizes the role of both public and private landowners in conservation efforts. The conversation also touches on the challenges posed by federal funding cuts and the need for a broader understanding of wildlife management. In this conversation, Dan Johnson and Patrick Wightman discuss ongoing research at the University of Georgia focused on wild turkeys, including innovative technologies being used to study their behavior and population dynamics. They explore the importance of collaboration among researchers, the future of wild turkeys in North America, and the impact of habitat management on turkey populations. The discussion highlights the challenges and advancements in turkey research, emphasizing the role of technology and conservation efforts. Takeaways: Patrick Wightman has been studying wild turkeys for about 10 years. His research focuses on wildlife ecology and management. Hunting experience provides a unique perspective on turkey research. Federal funding cuts are impacting wildlife research projects. Private landowners play a crucial role in habitat management. Recent years have shown a stabilization in turkey populations. Habitat loss is a significant factor in turkey mortality. Early successional habitat is vital for poult survival. State agencies manage turkey populations at a broader scale. Predation is a concern but is linked to habitat availability. We're looking at disease prevalence across these studies. We're putting GPS backpacks on these turkeys. The idea was to get gobbling chronology. It's very difficult to manage for a species where you don't know how many are on the landscape. We're hoping to learn enough about individual gobbling behavior. We can train computer software to identify differences in individual signatures. We have to get the unit back in hand for audio files. Increasing the habitat can absolutely increase the number of turkeys. Almost half of male mortality is from avian predation at night. We need to make the habitat the best we can. Learn more about your ad choices. Visit megaphone.fm/adchoices

When was the last time you read a beauty brand's sustainability report? If your answer is "never," you're not alone. Sustainability reports are often buried on company websites, obscured by glossy marketing materials that feel more like a promotional brochure than a genuine disclosure of progress. But what if you could look behind the curtain and examine what these brands are really doing for the planet? Now you can. In this episode of Green Beauty Conversations, host Lorraine Dallmeier, Chartered Environmentalist, Biologist, and CEO of Formula Botanica, dives deep into the truth behind beauty brand sustainability reports. Tune in now.     Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

Can a beauty brand grow, innovate, and achieve international success without compromising its core values? That's the question Lorraine Dallmeier, Chartered Environmentalist, Biologist, and CEO of Formula Botanica, asks in this week's episode of Green Beauty Conversations. Lorraine is joined by Laura Rudoe, founder of Evolve Organic Beauty. Together, they explore how Laura built a globally successful beauty brand while staying true to its sustainability and ethical values. Whether you're an indie entrepreneur or simply passionate about the beauty industry, this episode is for you.   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

Description: In this episode of Fishing the DMV, we sit down with North Carolina Wildlife Resources Commission biologists and avid anglers, Corey Oakley and Ben Ricks of Better Fishing with 2 Bald Biologists Podcast. These experts delve into North Carolina's diverse fish species, effective fisheries management, and ongoing conservation efforts. Gain insights into fish behavior, habitats, and the latest research to enhance your bass fishing success this spring. Whether you're a seasoned angler or new to the sport, this episode offers valuable information to elevate your fishing game in North Carolina's Rivers and lakes. Please support Fishing the DMV on Patreon!!!                 Patreon: https://patreon.com/FishingtheDMVPodcast  If you are interested in being on the show or a sponsorship opportunity, please reach out to me at fishingtheDMV@gmail.comCheck out Better Fishing with Two Bald Biologist Podcast Down below on Apple on Spotify: Apple podcast: https://podcasts.apple.com/us/podcast/better-fishing-with-2-bald-biologists/id1618055231Spotify: https://open.spotify.com/show/5mzPWCJ2IBuUaouB9QSArw?si=E91lDo9dSh28EeUfIz67qQ About This Video: Join us on the Fishing the DMV podcast as we uncover secrets revealed by biologists Corey Oakley and Ben Ricks Better Fishing with 2 Bald Biologists Podcast as the focusing on North Carolina bass fishing. This episode provides an in-depth fishing report for the upcoming spring bass fishing season, offering scientific perspectives to help you understand fish behavior and habitats. Explore river fishing opportunities and learn how to apply research-backed strategies to your angling adventures. Whether you're into kayak fishing, tournament fishing, or simply passionate about bass fishing, this conversation is packed with insights to improve your catch rate.Please checkout our Patreon Sponsors Jake's bait & Tackle website:                                http://www.jakesbaitandtackle.com/ Catoctin Creek Custom Rods: https://www.facebook.com/CatoctinCreekCustomRods Tiger Crankbaits on Facebook!! https://www.facebook.com/tigercrankbaits Fishing the DMV Facebook page: https://www.facebook.com/Arensbassin/?ref=pages_you_manage Fishing the DMV Instagram page: https://www.instagram.com/fishingthedmv/?utm_medium=copy_link   #bassfishing #fishingtheDMV #fishingtipsSupport the show

Send us a textWant to know the secrets to thriving fisheries? We talk with one of the nation's top biologists, Shane Bush from Missouri, about how they're working to create better fishing for everyone. Discover the science behind habitat restoration, fish conservation, and the critical role these efforts play in maintaining healthy lakes and rivers like Table Rock Lake. Get ready to learn something new!

Imagine starting a beauty brand with no financial backing, formal training, or industry guidance—armed only with determination and a dream. This is the story of Elizabeth Arden, who transformed her kitchen-made creams into one of the most iconic beauty empires of all time. But it's also the story of so many modern-day indie beauty entrepreneurs. In this episode of Green Beauty Conversations, Lorraine Dallmeier, Chartered Environmentalist, Biologist and CEO of Formula Botanica explores the parallels between Elizabeth Arden's legacy and today's indie beauty movement. Tune in now to discover 8 powerful lessons every indie beauty entrepreneur needs to know to build a purpose-driven, impactful brand.   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

Elizabeth Arden is one of the most iconic figures in the beauty industry, known for building a global empire from modest beginnings. Her remarkable journey is a testament to vision, innovation, and determination—and surprisingly mirrors the path of many modern-day indie beauty entrepreneurs. In this episode of Green Beauty Conversations, Lorraine Dallmeier, Chartered Environmentalist, Biologist and CEO of Formula Botanica, sits down with Professor Stacy Cordery to explore the life of this pioneering entrepreneur. Tune in now for an inspiring conversation you won't want to miss! And for a deeper dive into Elizabeth Arden's extraordinary story, make sure to grab a copy of Stacy's book, "Becoming Elizabeth Arden: The Woman Behind the Global Beauty Empire."   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram

Are beauty retailers crossing the line with their self-imposed standards, or are they stepping in to fill a much-needed regulatory gap? That's what Lorraine Dallmeier, Chartered Environmentalist, Biologist, and CEO of Formula Botanica, sets to find out in this week's episode of Green Beauty Conversations. Do you see this shift as a win for transparency, or does it make shopping for beauty products even more confusing? Tune in and share your thoughts—we'd love to hear from you!   Free Resources Free formulation course | Green Beauty Conversations Podcast | Blog | YouTube Socials: Formula Botanica on Instagram | Lorraine Dallmeier on Instagram