Podcasts about sirt

Immunic Inc chief medical officer Dr Andreas Muehler talked with Proactive's Stephen Gunnion about new developments in celiac disease research during Celiac Disease Awareness Month. He emphasized the seriousness of the autoimmune condition, noting it is often misdiagnosed due to vague symptoms. “Celiac disease is a really important disease with significant consequences for patients,” Muehler said, citing malnutrition, infertility, and even malignancy risks as complications. The emotional and social toll of the condition, he added, is also substantial, with many patients facing isolation due to dietary restrictions. Muehler discussed Immunic's investigational drug IMU-856, which targets the SIRT-6 protein to regenerate intestinal lining and strengthen gut barrier function. Early results from a Phase 1b trial involving 43 patients indicated improvements across multiple measures: bowel histology, disease symptoms, biomarkers, and micronutrient absorption. At the recent DDW conference, Immunic presented data showing IMU-856's efficacy even in patients with severe intestinal damage. Additionally, the drug's absorption was not hindered by pre-existing gut damage, an encouraging sign for future use. Muehler also noted the drug's impact on GLP-1 hormone levels, aligning with emerging gastrointestinal treatment trends. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #CeliacDisease #ImmunicInc #IMU856 #AutoimmuneDisorders #GutHealth #BiotechNews #DDW2025 #CeliacTreatment #Epigenetics #GLP1 #MedicalResearch

Genflow Biosciences PLC (LSE:GENF, OTCQB:GENFF) CEO Dr Eric Leire talked with Proactive about the company's new strategic partnership with US-based Heureka Labs, a spinoff of Duke University, to enhance its gene therapy research using AI technology. Leire said: “Every biotech in gene therapy should have an AI component. If you don't have that, you miss a critical tool to unlock value for your shareholders.” He stressed the need for a multi-omics approach—genomic, transcriptomic, and proteomic—to better understand gene expression and drug response, which traditional analysis methods struggle to fully capture. The partnership with Heureka Labs, which integrates deep AI and biological expertise, will initially support Genflow's lead candidate, GF-1002, a SIRT-6 gene therapy targeting MASH (metabolic dysfunction-associated steatohepatitis). AI will help the company analyse complex preclinical data, including insights from nearly 700 mice tested, to understand mechanisms of action and identify likely responders—crucial in discussions with regulators such as the FDA and EMA. Leire also emphasised that the collaboration is scalable across Genflow's pipeline, helping unlock synergies between programmes in liver, muscle, and eye diseases. For more interviews like this, visit Proactive's YouTube channel. Don't forget to give this video a like, subscribe to the channel, and enable notifications for future content. #GenflowBiosciences #GeneTherapy #AIinBiotech #BiotechNews #MASH #SIRT6 #HeurekaLabs #DrugDevelopment #MultiOmics #BiotechPartnership #FDA #EMA #PreclinicalResearch

Exklusives Coaching und Webinare mit Dr. Bredehorst: https://cellsciencepodcast.de/Dr. Kay Bredehorst über Bryan Johnson und David Sinclair und was wirklich dran ist.mTOR, Sirt Gene und Longevity sindBioverfügbares Kurkuma: https://mitocare.de/products/lipo-curcumin-boosterCode: V60014Achtung: Iss Getreide, Hülsenfrüchte oder Mais niemals roh. Die besten Ernährungstipps für einen gesunden Darm und warum Kurkuma zu 99% nicht aufgenommen wird, erfährst du in diesem Video.Inhaltsverzeichnis:00:00 Intro04:30 Vorteile pflanzlicher Ernährung07:20 SIRT - Zellen die ständig im Betrieb sind, gehen kaputt10:30 Fasten13:00 NMN ist Novel Food (In Deutschland verboten!!)15:00 NAD wird hier genutzt. SIRT arbeitet danach schneller19:00 mTOR POWER (Zucker und Protein)22:30 Gesunde Lebensmittel und sekundäre Pflanzenstoffe29:30 AMPK Gen und Bewegung34:30 RegenerationsphasenMehr Infos zu ….–Mehr von Mr. Broccoli:Homepage: https://www.vegan-athletes.comAbonniere meinen YouTube Kanal: https://www.youtube.com/@mrbroccoliInstagram: https://www.instagram.com/mrbroccoli.official/Telegram (für besonders brisante Themen): https://t.me/mrbroccoli_veganNewsletter: https://www.vegan-athletes.com/newsletter-vegan-athletes/➤➤➤ Meine 10 Favoriten für mehr Gesundheit: https://www.vegan-athletes.com/empfehlungen/

ABOUT THIS EPISODEIn this 2-part series, Dr. Osman Ahmed from the University of Chicago covers liver-directed therapies for neuroendocrine neoplasms (NENs or neuroendocrine cancer). In this second episode, he details the embolization techniques, including bland embolization (TAE), chemoembolization (TACE), and radioembolization (TARE, SIRT, y90). He discusses decision-making, sequencing, and follow-up after these procedures.TOP TEN QUESTIONS ABOUT LIVER-DIRECTED THERAPY PART 2:1. What do patients need to know about bland embolization (TAE)? a. What are the possible side effects? b. How do the size of beads play a role? c. When is this recommended? d. Do you always do both sides of the liver? If so, what is the timing and why? e. What is the recovery like? What is post-embolization syndrome?2. What do patients need to know about chemoembolization (TACE)?a. What drug is used & does this go through the whole body? b. What is the recovery like? What are the possible side effects?3. What do patients need to know about radioembolization (TARE, SIRT, y90)? a. In the era of PRRT, is there a concern with using y90 or radioembolization? How is the approach and technique used with radioembolization different than how it was done in the past? Is there a total lifetime limit of radiation?b. What is the recovery like? What are the possible side effects?4. Is there a limit to how much LDT one can do? Can they be repeated?5. How does one decide between the various types of liver-directed therapies?6. Is there a sequencing to treatments?7. Are there certain treatments that make you ineligible for other treatments? [PRRT, chemo, y90 etc] 8. If someone has had surgery such as a Whipple or surgery or procedures involving the bile duct, such as a stent in the bile duct or surgical removal of part of the bile duct, how does this weigh into the decision-making process for LDT?9. How do you determine if the treatment “worked?” What is the follow-up like? What scan might you do and in what timing?10. What do you see as the future of liver-directed therapy in neuroendocrine cancer treatment? MEET DR. OSMAN AHMEDOsman Ahmed, MD, is an expert vascular and interventional radiologist who diagnoses and treats a wide range of conditions. Using image-guided technology and small, sophisticated instruments, Dr. Ahmed performs minimally invasive procedures for acute and chronic deep vein thrombosis, benign prostatic hyperplasia, peripheral vascular disease, liver/bone/lung/kidney cancer, spinal fractures, uterine fibroids and more. He also implants inferior vena cava (IVC) filters, which prevent a blood clot from traveling around the body or creating a blockage.In addition to his clinical expertise, Dr. Ahmed researches novel treatment options that improve outcomes for patients. His research on liver cancer, IVC filters and venous diseases has been published in several high-impact, peer-reviewed journals, including the Journal of Vascular and Interventional Radiology, Radiology, Chest, Journal of American College of Radiology, and Journal of Surgical Oncology.Dr. Ahmed also believes in the importance of educating medical students, residents, fellowships and peers in order to enhance health care across the world. He has been invited to speak at a number of symposiums, practicums and national/international meetings about the newest advancements in interventional radiology.For more information, visit https://www.lacnets.org/lacnets-podcastFor more information, visit LACNETS.org.

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Canadian journalist Nora Loreto reads the latest headlines for Tuesday, May 21, 2024.TRNN has partnered with Loreto to syndicate and share her daily news digest with our audience. Tune in every morning to the TRNN podcast feed to hear the latest important news stories from Canada and around the world.Find more headlines from Nora at Sandy & Nora Talk Politics podcast feed.Help us continue producing radically independent news and in-depth analysis by following us and becoming a monthly sustainer.Sign up for our newsletterLike us on FacebookFollow us on TwitterDonate to support this podcastReferenced articles:Story 1 - SIRT investigating after " officer-involved shooting: in Regina. Story 2 - Unexploded incendiary devices found at site of future EV battery site. Story 3 - Omar Khadr denied an appeal with the US Supreme Court. Story 4 - Top Iranian officials die in helicopter crash in region blanketed in thick fog.Story 5 - The ICC issues arrest warrant for leadership of both Hamas and Israel, will allow events of Oct. 7 and the genocide of Gaza to be examined in court. Story 6 - Julian Assange wins the right to appeal his extradition to the US.

Story 1 - SIRT investigating after " officer-involved shooting: in Regina. Story 2 - Unexploded incindiary devices found at site of future EV battery site. Story 3 - Omar Khadr denied an appeal with the US Supreme Court. Story 4 - Top Iranian officials die in helicopter crash in region blanketed in thick fog.Story 5 - The ICC issues arrest warrant for leadership of both Hamas and Israel, will allow events of Oct. 7 and the genocide of Gaza to be examined in court. Story 6 - Julian Assange wins the right to appeal his extradition to the US. Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.

This week, I start with a look down south to the charges against world #1 golfer, Scott Scheffler, before the second round of the PGA Championship. I also examine the cross examination of former personal lawyer to Donald Trump, Michael Cohen, in the trial against the former President. In Canadian stories, I discuss the McGill University injunction application, seeking to end the student protests. I also review the case of the Nova Scotia government versus the Federal government over the needed upgrades to the Chignecto Isthmus. Also covered are the conviction of Colin Tweedy in his retrial over the death of 10-year old Talia Forrest, the not-guilty pleas and seeking of bail in the death of Halifax teen Ahmad Al Marrach, and the retirement of Ron MacDonald, former Anitgonish prosecutor, head of SiRT, and for the past seven years the head of the BC equivalent. Ron had some wise parting words, which other like organizations should heed.

This week, I cover the appointment of the new NS Justice Minister and SiRT Director, the Toronto Police Chief's Comments in the Zameer acquittal, former President Trump's claim to criminal immunity at the US Supreme Court, and how Harvey Weinstein's successful appeal would have played out in Canada. Before that, I discuss the Pierre Poilievre well-received visit to eastern Nova Scotia and Cape Breton, and his controversial stop at the NS/NB border.

Riding Shotgun With Charlie #201 Matt Mallory & Klint Macro Meet The Pressers   It's always a great time to run into Matt & Klint from Meet The Pressers. We filmed a show at SHOT in 2020. And they let me use their car to film a couple other shows. This year we were able to film another show on SHOT's Range Day.    Since our last show, Matt has been busy getting and giving training with Public Safety & Education, his training company. He offers several of the NRA and USCCA courses. But he is also a Master Instructor for SABRE Pepper Spray and for the TASER Civilian Course. He travels the country teaching these classes. Of course, he also offers several other training opportunities. Since the Bruen decision in June 2022, he's been doing the 18, yes EIGHTEEN, hour course to get a carry permit in New York. The NY Governor signed the Concealed Carry Improvement Act, or the Concealed Carry Improvement Atrocity as he calls it. He was able to take topics and lessons from his other courses to meet the 18 hour requirement and qualification. Some states like Massachusetts, have approved courses. States like New York have approved content in the course.    Another new course is the Build Your Own 2A BeAR. You can build your own AR-15 style rifle, with a pinned magazine, which makes the rifle not an “assault weapon”. Matt offers about 95 different courses through PS&Ed, including teaching at the local police academy.   Other than that, Matt and I have been doing a LIVE show on our YouTube channels. We're honored that Mantis and Next Level Training are our sponsors of the show. And we give away a Mantis X10 and a SIRT pistol every month.    Klint is holding his own in the keeping busy department. He's had LASIK surgery on his eyes. Yes, it may seem weird to talk about eye surgery on a gun show. The reason he did it is because if someone broke into his home, got into a confrontation, and swiped his face and knocked his glasses off, he wouldn't be able to see them anymore. This is the outside of the box thinking that Klint does.    He's also a consultant with the USCCA. They have him training the trainers all around the country. As a consultant for the USCCA''s official partners, he helps instructors build a training path for their clients. Some duties include helping with marketing and retaining clients.    He's been working with them for years, but they offered him a position he couldn't turn down. He's also been able to keep his training company, Trigger Pressers Union, offering courses. He's doing classes with Personal Defense Network, running National Train a Teacher's Day, president of Allegheny County Sportsman League. He's the Vice President of Firearm Owners Against Crime. The most challenging part of all Klint's gigs is keeping his hats separated and on correctly. He can't speak for one group when he's representing a different one or speaking to a different group.    Klint talks about how after the government lockdowns of 2020, there were lots of people making purchases and seeking out training. This was very different from previous generations of gun owners. People want to buy firearms and take some training not because its required, but because they want to know how to use their new guns safely. Often he'll tell folks to offer a basic course on having a firearm in the home and teach people how to be better consumers.    Matt and Klint have a lot going on, individually and as a team. Between the courses locally and around the country, they're always on the go. You should take a course with either of them when they're in your area. And tell them Charlie said Hello! Favorite quotes: Matt: “It's a corrupt government in New York state… It's legalized crime.” Matt: “I'm not going to let them walk out with a certificate if they can't keep their finger off the trigger when it's important.” Klint: “All the stuff I had in place would mean nothing if you knocked off my glasses.” Klint: “I believe my purpose is to help empower my fellow Americans to exercise that Right to protect themselves and their families and to be their own first responders.” MTP Website https://meetthepressers.com/   MTP YouTube https://www.youtube.com/c/meetthepressers   MTP FB https://www.facebook.com/MeetThePressers/   MTP IG https://www.instagram.com/meetthepressers   Trigger Pressers Union https://triggerpressersunion.com/index.html   Trigger Pressers Union https://www.facebook.com/profile.php?id=100063643621298   Trigger Pressers Union https://www.instagram.com/trigger_pressers_union/   PS & Ed Website https://psanded.com/   PS & Ed IG https://www.instagram.com/psandeducation/   PS & Ed FB https://www.facebook.com/psanded/ Second Amendment Foundation https://secure.anedot.com/saf/donate?sc=RidingShotgun    Citizens Committee for the Right to Keep and Bear Arms https://www.ccrkba.org/     Please support the Riding Shotgun With Charlie sponsors and supporters.    Buy RSWC & GunGram shirts & hoodies, stickers & patches, and mugs at the store! http://ridingshotgunwithcharlie.com/rswc-shop/   Dennis McCurdy Author, Speaker, Firewalker http://www.find-away.com/   Self Defense Radio Network http://sdrn.us/   Buy a Powertac Flashlight, use RSWC as the discount code and save 15% www.powertac.com/RSWC   SABRE Red Pepper Spray  https://lddy.no/1iq1n  

In Episode 74, Sofia interviews Mike Hughes, the Founder of SIRT and NextLevel Training. Mike is a multifaceted individual with a diverse range of achievements and experiences, from being a contestant on the History Channel's Top Shot Season Three, to founding and presiding over Next Level Training in Ferndale, Washington. Mike's journey began at the University of Idaho, where he played college football. He then pursued a career in law, practicing for over a decade. His love for competition and precision, however, led him to the History Channel's Top Shot. Despite an early elimination, Mike made an unexpected return to the competition, reaching the Season 3 Finale.Stepping beyond his television fame, Mike is also recognized in the world of competitive shooting. As a United States Practical Shooting Association competitor, he secured a commendable 7th place at the Nationals competition. This obsession with speed and accuracy, combined with his love for fundamental skills, inspired him to invent the SIRT Pistol, a top training tool used across military, law enforcement, and private training organizations.With his relentless pursuit of excellence and his dedication to enhancing training methodologies, Mike Hughes is a compelling figure in the field of competitive shooting and training. Please join me in welcoming Mike to the She Shield Podcast.Bio adapted from the Mike Hughes Podcast Episode by Concealedcarry.com To listen and or read the article click here: https://www.concealedcarry.com/offers/mike-hughes-next-level-training-founder-and-top-shot-contestant/Follow the pod on instagram for more episode updates @sheshieldpod. Thank you all for your encouragement and support. If you are interested in exclusive content, become a Patreon here: https://www.patreon.com/sheshieldpodPodcast Sponsors: Links and CodesCiguera Gear: Use the code "SHESHIELD10" for 10% off your next Ciguera Gear order to save and support the pod! https://ciguera.com/ Big Tex Ordnance: your soon-to-be favorite retailer for all of your firearms needs. Use code “FIT4FIA” for 10% off your BTO order and to support the pod via https://www.bigtexordnance.com/?ref=79990 Walkers Inc. Hearing Protection: Use code “SHESHIELD” to save and to support the pod https://www.walkersgameear.com/ SOG: Use code “SHESHIELD” to save and to support the pod https://sogknives.com/ GPS Range Bags: Use code “SHESHIELD” to save and to support the pod https://www.goutdoorsproducts.com/ Birchwood Casey: Use code “SHESHIELD” to save and to support the pod  https://www.birchwoodcasey.com/ Cold Steel: Use code “SHESHIELD” to save and to support the pod https://www.coldsteel.com/ All links: https://linktr.ee/sheshieldpodHold My Guns Firearms Storage for Those in Need: https://www.holdmyguns.org/Resources mentioned in this episode: 1. Next Level Training: https://nextleveltraining.com/2. Mike's Socials: https://www.instagram.com/mikehughessirt/3. Refined Savages Website: https://refinedsavages.com/4. G Spot Fire Starter Kit: https://refinedsavages.com/product/firestarter/

This week, I start by reviewing the Cameron Ortis sentencing hearing, including the intervention of Michael Kovrig, who wrote a letter in support of Ortis that brought to mind the movie 'Catch Me If You Can'. I explain why the Crown and Defense positions can sometimes be so far apart from one another. Next, I discuss the RCMP's failure to meet their year end deadline to submit a response to the recommendations of the Mass Casualty Commission. Also, I review the stalled efforts to have the wrongful conviction of Glen Assoun investigated, and what SiRT should do next. The Prime Minister took another Christmas vacation to Jamaica, and is now the subject of another complaint to the Ethics Commissioner. There have been conflicting statements from the PMO and the office of the Commissioner. I review the Conflict of Interest Code to try to provide clarification. Then, I look internationally to the case brought before the International Court of Justice by the South African government, accusing Israel of genocide, looking at the merits and the politics of the allegations. Finally, I comment on the difference between Canada and the United States when it comes to elected judges (wherein I work in a Bob Dylan quote), and how that is manifesting itself in the various cases involving Donald Trump.

Just over one year after it was formed, the Saskatchewan Serious Incident Response Team (SIRT) has released its first report. The report details an investigation into an injured suspect in a June incident involving Regina police, finding police free of wrongdoing. SIRT executive director, Gregory Gudelot, joins Evan to talk about the first completed final report and how the teams first year in action went.

This week in law, the Serious Incident Response Team's interim director is busy revisiting cases - the Onslow-Belmont shooting during the NS Mass Shooting, and the wrongful conviction of Glen Assoun. The NS Court of Appeal had harsh words for Provincial Court Judge Alain Begin after Judge Begin made remarks about an accused before closing arguments, and then tried to have those comments removed from the record that would go to the Court of Appeal. After the Randy Riley not guilty verdict, the Witness Protection Plan tried to have a publication ban made retroactive, but were rightly turned down by Justice Arnold. Finally, I discuss the housing crisis, and how courts are likely to treat any efforts to remove tent encampments from public property. Also discussed in this episode, the UK hockey manslaughter charge, President Trump's efforts to be declared immune from criminal prosecution, and the Cameron Ortis guilty verdict.

Dersimiz Fitness'ın bu bölümünde her kas grubunu geliştirmek için uygulayabileceğin en etkili hareketler konuşuldu. Sende spor salonunda vakit kaybetmeden az sürede çok iş başarmak istiyorsan bu bölümü kaçırma. (00:00:21) Hareketler kime göre, neye göre etkili? Hareketleri sevmediğin için mi yapmıyorsun yoksa iyi olmadığın için mi?  (00:05:59) Hareketler arasındaki hiyerarşi (00:11:06) Hareketin kadını erkeği olur mu? Sorunun gerçekten yağlı olmak mı? (00:14:00) Egzersiz seçimini neye göre yapman gerekiyor? Hareketleri yaparken dikkat etmen gereken en önemli konu ne? (00:21:49) Neden serbest ağırlık? https://youtu.be/vZfNwkvrAzw  - (00:25:14) GÖĞÜS https://youtu.be/_MDaqQOeBOk  Bahsi Geçen Egzersizler: Bench Press, Dumbbell Chest Press, Incline Chest Press, Dumbbell Chest Fly, Floor Press Dumbbell Chest Fly Nasıl Yapılır? (Detaylı Teknik Açıklama) https://youtu.be/KjmNK0zb28M - (00:30:17) SIRT  https://youtu.be/f5CFQi8GTOM  Bahsi Geçen Egzersizler: Deadlift, Row, Pull-up, T-Bar Row, Pullover Deadlift Nasıl Yapılır?: https://youtu.be/idlcJXvoS8Y https://youtu.be/05HrjBEtRy4  Asılmak Neden Bu Kadar Önemli? | 7'den 70'e Herkesin Uygulayabileceği Asılma Antrenmanları https://youtu.be/gPZGBFkmSgU  - (00:40:51) BACAK (kalça, ön bacak, arka bacak, calf) Bahsi Geçen Egzersizler: Squat, Hip Thrust, Romanian Deadlift, Physio Ball/TRX Hamstring Curl, Rear Lunge, Step-up, Front Squat, Sumo Deadlift, Bulgarian Split Squat, Heel Elevated Squat, Nordic Curl, Seated and Standing Calf Raise Squat Nasıl Yapılır?: https://youtu.be/JFqwynDbuco  https://youtu.be/qMAi334GnrI  - (00:48:31) OMUZ (ön + yan + arka omuz, trapez) https://youtu.be/Hj8S68r2_xE?feature=shared  Bahsi Geçen Egzersizler: Barbell Overhead Press, Z Press, Dumbbell Lateral Raise, Dumbbell Rear Delt Fly, Plate Around The World, Shrug, High Pull, Upright Row, Upsidedown Kettlebell Press DB Rear Delt Fly Nasıl Yapılır?: https://youtu.be/eSRS61gJbBg?feature=shared  - (00:54:20) KOL (biceps, triceps) https://youtu.be/JT1n2AJSUeI?feature=shared  Bahsi Geçen Egzersizler: Chin-up, Barbell Curl, Incline Curl, Preacher Curl, Hammer Curl, Skull Crusher, Close Grip Bench Press, Dips - (00:58:17) KARIN (+obliques) https://youtu.be/zo5UB_I7_f8?feature=shared https://youtu.be/CzOv4eY_toQ?feature=shared Bahsi Geçen Egzersizler: Hanging Leg Raise, Lying Leg Raise, Decline Sit-up, Reverse Crunch, Cable Crunch, V Sit-up, L Sit-up, Side Plank, Active Plank - Sosyal Medya: https://linktr.ee/dersimizfitness  Email: bilgi@dersimizfitness.com Hepinize güzel yorumlarınız için teşekkürler!  --- Send in a voice message: https://podcasters.spotify.com/pod/show/dersimiz-fitness/message

This week in NS and Canadian law, there were reviews announced, reports released, new judges named, and a progress monitoring committee meeting. The two new NS Provincial Court judges are Alonzo Wright and Mark Heerema. Judge Wright was most recently the Director of the Serious Incident Response Team, which investigates potential misbehaviour among police officers in NS. He was new to that position, and now SIRT is in the hands of an interim Director. Judge Heerema was a Provincial Prosecutor, who had recently been defending the government's secretive approach to releasing information on the NS mass shooting. The Mass Casualty Commission Progress Monitoring Committee met this week, and released very little information afterwards. It has now been six months since the release of the MCC final report, and few (if any) of the recommendations have been implemented. One recommendation had been to conduct a review of policing in NS. The government announced this week that there would be a review, with the report expected in about a year and a half from now, just before the next election. The same timing is applicable to the other review announced this week, that of the Freedom of Information system in NS. There was news out of the Cape Breton Regional Municipality, where the fire chief, Michael Seth, resigned. It was then revealed that Chief Seth had made a harrassment complaint against four councilors regarding comments made about changes to celebrations planned for July 1st. A report from an employment lawyer found that harassment had taken place. I take a critical view of that report. Finally, the Saskatchewan Supreme Court has granted an injunction against the government implementing an education policy aimed at ensuring parental consent before any student under age 16 can use their choice of pronouns or names in school. Premier Moe has indicated the government will use the notwithstanding clause of the Charter to ensure the policy is followed. I examine the decision, and predict how the issue will play out in courts and legislatures in the months to come.

In this weekly series, I'm joined by investigative journalist Paul Palango and legal analyst Adam Rodgers to discuss Canadian stories of crime, corruption, and items of public interest. In this episode we discuss; the Halifax Police shooting of Aug 24, 2023 calls to reopen the SIRT investigation to the Onslow Belmont Firehall shooting protests against wildfire related roadblocks in British Columbia Series Links: Join the discussion Group: https://www.facebook.com/groups/sundaynight Send a voicememo to the show: nighttimepodcast.com/contact Subscribe to the show: Premium feed: https://www.patreon.com/Nighttimepodcast Apple Podcasts: https://applepodcasts.com/nighttime Spotify: https://open.spotify.com/show/3nZztXBziqQv5KcPG1m5k8?si=ed168b2235a94632 Musical Theme: Noir Toyko by Monty Datta Social Links: Website: https://www.nighttimepodcast.com Twitter: https://twitter.com/NightTimePod Facebook: https://www.facebook.com/NightTimePod Instagram: https://www.instagram.com/nighttimepod Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode the boys get hyped about SIRT and deacetylation

Our guest, Allen West from Akamai's SIRT team, joins Dave to discuss their research on "The Dark Frost Enigma: An Unexpectedly Prevalent Botnet Author Profile." Akamai found this new botnet was targeting the gaming industry, modeled after Qbot, Mirai, and other malware strains. The botnet has expanded to encompass hundreds of compromised devices. The research states "through reverse engineering and patching the malware binary, our analysis determined the botnet's attack potential at approximately 629.28 Gbps with its UDP flood attacks." Akamai researchers do a deep dive into the motives behind the attacks, the effectiveness of the attack, and how the law has been handling similar cases. The research can be found here: The Dark Frost Enigma: An Unexpectedly Prevalent Botnet Author Profile

Our guest, Allen West from Akamai's SIRT team, joins Dave to discuss their research on "The Dark Frost Enigma: An Unexpectedly Prevalent Botnet Author Profile." Akamai found this new botnet was targeting the gaming industry, modeled after Qbot, Mirai, and other malware strains. The botnet has expanded to encompass hundreds of compromised devices. The research states "through reverse engineering and patching the malware binary, our analysis determined the botnet's attack potential at approximately 629.28 Gbps with its UDP flood attacks." Akamai researchers do a deep dive into the motives behind the attacks, the effectiveness of the attack, and how the law has been handling similar cases. The research can be found here: The Dark Frost Enigma: An Unexpectedly Prevalent Botnet Author Profile Learn more about your ad choices. Visit megaphone.fm/adchoices

Today we are talking about extending our healthspan & longevity with Alan Graves, the CEO of Do Not Age! He shares his thoughts on the Longevity Escape Velocity theory, which is the idea that one's remaining life expectancy will be extended longer than the time that is passing. Some experts claim we will be there by 2036, although Alan disagrees! We dive into some of the top anti-aging nutrients on the market such as NMN, Resveratrol, Apigenin, and SIRT-6, as well as the important lifestyle factors that will support a long healthy life.Alan Graves is the CEO of DoNotAge.org, a global health research organization and the largest NMN supplier in the world.SHOW NOTES:0:51 Welcome to the show!1:55 Pop Quiz of the Day4:15 Today's interview topic6:56 Alan Graves' Bio7:18 Welcome him to the podcast8:15 His goal for longevity & definition of health9:54 Thoughts on “Longevity Escape Velocity Theory”11:53 What behavioral choices are the most powerful?12:47 Advice on diet, macros & micronutrients14:19 Hormetic Stressors, ie: Resveratrol15:14 Supplements vs Diet17:01 Offsetting jet lag with Creatine & NMN19:35 Stem Cells20:52 Testing with Do Not Age21:33 NAD Explained23:10 Lauren & Renee's experience with NAD24:19 NAD vs NMN vs NR26:36 Do we need to supplement forever?28:11 *Magnesium Breakthrough*30:15 The importance of supplement routines33:05 Benefits & Dosing for Resveratrol35:05 What are Sirloins?38:24 Sirt-6 & Cancer [see video for study]42:05 What one supplement will help us live forever?42:31 *LightPath LED*45:46 Avoiding medical advice46:49 Long-term need for support47:17 Supplementing with TMG49:02 Starter Pack & Quercitin51:18 DoNotAge Quality & Sourcing55:50 How to get started58:33 His final piece of advice59:24 Thanks for tuning in!RESOURCES:Website: DoNotAge.org - Discount code: BIOHACKERBABESInstagram: Do.Not.AgeFacebook: Do Not AgeTwitter: Do Not AgeL-Baiba - the magic exercise pill?Magnesium Breakthrough - Discount code: biohackerbabes10LightPathLed - Save 5% with discount code: BIOHACKERBABESSupport this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

In Episode 42 Sofia interviews Annette Evans, the founder of "On Her Own." Annette shares her self-defense timeline as a student and instructor, her experience with various forms of concealed carry, her experience as a competitive shooter, and more. Follow us on instagram for more episode updates @sheshieldpod. Thank you all for your encouragement and support. If you are interested in exclusive content, become a Patreon via the linktree.Thank you to Ciguera Gear for sponsoring this episode. Use the code "SHESHIELD10" for 10% off your next Ciguera Gear order to save and support the pod!All links: https://linktr.ee/sheshieldpodResources mentioned in this episode:1. On Her Own Website: https://onherown.life/2. Annette Evans Instagram: https://www.instagram.com/onherownlife/?hl=en3. Flashbang https://www.flashbangstore.com/products/flashbang-holster?gclid=CjwKCAiAuOieBhAIEiwAgjCvcjqCBYEwEuaKjn-oiN8N2aoS6KFzzHgm2l8beNWyT4Tli2U0II8evhoCIusQAvD_BwE 4. Shivworks https://shivworks.com/extreme-close-quarter-concepts/ 5.Sirt pistol https://nextleveltraining.com/product/sirt-110-training-pistol-2/ 6. Blue gun: https://www.blueguns.com/ 7. Kathy Jackson https://www.corneredcat.com/article/introduction/about-the-author/

This episode features guests Paul Palango and Adam Rodgers. Our conversation covers; the release of Whatsapp message showing senior RCMP officers criticizing emergency responders request for reduced workloads in the days after the mass casualty. Further details that call into question the SIRT investigation into the Onslow Fire Hall Episode Links: the Nova Scotia Mass Shooting Timeline Episode: https://www.nighttimepodcast.com/episodes/nova-scotia-mass-shooting-timeline the Nova Scotia Mass Shooting Series: https://www.nighttimepodcast.com/nova-scotia-rampage Join the Nova Scotia Mass Casualty Discussion Group: https://www.facebook.com/groups/novascotiamasscasualty Send a tip related to this case: https://www.nighttimepodcast.com/contact Send a voicememo to the show: nighttimepodcast.com/contact Subscribe to the show: Premium feed: https://www.patreon.com/Nighttimepodcast Apple Podcasts: https://applepodcasts.com/nighttime Spotify: https://open.spotify.com/show/3nZztXBziqQv5KcPG1m5k8?si=ed168b2235a94632 Musical Theme: Noir Toyko by Monty Datta Social Links: Website: https://www.nighttimepodcast.com Twitter: https://twitter.com/NightTimePod Facebook: https://www.facebook.com/NightTimePod Instagram: https://www.instagram.com/nighttimepod Learn more about your ad choices. Visit megaphone.fm/adchoices

This week, I discuss some reconciliation videos being filmed, including one I did with Chief Stephen Augustine on the legacy of Donald Marshall Jr., the most impactful individual litigant in Canadian history, in my view. In the news this week, the NS Mass Casualty Commission continues to release new information, even though proceedings have concluded. This week featured a memo regarding the Onslow Belmont Fire Hall shootings, which was quite critical of the officers who did the shooting, and SiRT for clearing them of liability. The NS Court of Appeal wrote an unusual letter to the NS Bar Society complaining about the large number of appeal hearings being adjourned in recent months. A doctor from Amherst has had three sexual assault charges stayed, as the court tries to sort out whether a Crown prosecutor who had previously represented a potential victim in a civil suit against the doctor is in conflict. NS Power has extortionary legal authority by virtue of the NS Power Privatization Act. One is an insulation against liability for power outages. I discuss how that might change. Finally, this week in the Emergencies Act Inquiry, the National Security Advisor to the Prime Minister sought to re-define how the Inquiry should interpret what it means to be a "public order emergency". I discuss why I do not find her submission persuasive.

This episode features guests Paul Palango and Adam Rodgers. Our conversation covers; recent photos of Gabriel Wortman wearing a wig?!? a Chatelaine magazine article questioning the public discourse surrounding Lisa Banfield the integrity of the SIRT investigations into the Onslow Fire Hall shooting and the Big Stop takedown of Wortman Episode Links: the Nova Scotia Mass Shooting Timeline Episode: https://www.nighttimepodcast.com/episodes/nova-scotia-mass-shooting-timeline the Nova Scotia Mass Shooting Series: https://www.nighttimepodcast.com/nova-scotia-rampage Join the Nova Scotia Mass Casualty Discussion Group: https://www.facebook.com/groups/novascotiamasscasualty Send a tip related to this case: https://www.nighttimepodcast.com/contact Send a voicememo to the show: nighttimepodcast.com/contact Subscribe to the show: Premium feed: https://www.patreon.com/Nighttimepodcast Apple Podcasts: https://applepodcasts.com/nighttime Spotify: https://open.spotify.com/show/3nZztXBziqQv5KcPG1m5k8?si=ed168b2235a94632 Musical Theme: Noir Toyko by Monty Datta Social Links: Website: https://www.nighttimepodcast.com Twitter: https://twitter.com/NightTimePod Facebook: https://www.facebook.com/NightTimePod Instagram: https://www.instagram.com/nighttimepod Learn more about your ad choices. Visit megaphone.fm/adchoices

An interview with Dr. Van Morris from The University of Texas MD Anderson Cancer Center in Houston, TX and Dr. Cathy Eng from Vanderbilt-Ingram Cancer Center in Nashville, TN, co-chairs on "Treatment of Metastatic Colorectal Cancer: ASCO Guideline." Dr. Morris and Dr. Eng review the evidence-based recommendations from the guideline, focusing on areas of uncertainty in the treatment of metastatic colorectal cancer, and highlighting the importance of multidisciplinary collaboration and shared decision-making between patients and clinicians. Read the full guideline at www.asco.org/gastrointestinal-cancer-guidelines.   TRANSCRIPT Brittany Harvey: Hello, and welcome to the ASCO Guidelines Podcast series, brought to you by the ASCO Podcast Network; a collection of nine programs covering a range of educational and scientific content and offering enriching insight into the world of cancer care. You can find all the shows, including this one, at: asco.org/podcasts. My name is Brittany Harvey, and today I'm interviewing Dr. Van Morris, from The University of Texas MD Anderson Cancer Center in Houston, Texas, and Dr. Cathy Eng from Vanderbilt-Ingram Cancer Center in Nashville, Tennessee - co-chairs on, 'Treatment of Metastatic Colorectal Cancer, ASCO Guideline.' Thank you for being here, Dr. Morris, and Dr. Eng. Dr. Cathy Eng: Thank you. Dr. Van Morris: Thank you. Brittany Harvey: First. I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest policy is followed for each guideline. The full Conflict of Interest information for this guideline panel is available online with the publication of the guideline in the Journal of Clinical Oncology. Dr. Morris, do you have any relevant disclosures that are directly related to the guideline topic? Dr. Van Morris: Not personally, but I do have research support to my institution from Pfizer and Bristol Myers Squibb who have products that I'll be discussing on this podcast. Brittany Harvey: Thank you, Dr. Morris. And Dr. Eng, do you have any relevant disclosures that are directly related to this guideline topic? Dr. Cathy Eng: Also, not personally associated with any honorarium specific to this topic. Brittany Harvey: Great. Thank you both. So then, let's talk about the content of this guideline. So first, Dr. Morris, can you provide an overview of the scope of this guideline? Dr. Van Morris: Sure. So colorectal cancer is the second-leading cause of cancer-related death in the United States. And especially in the time of the recent COVID-19 pandemic with people less likely to go for screening colonoscopies, there's great concern that more and more patients will be presenting at the time of their initial diagnosis with later-stage, more advanced colorectal cancer. So with that said, research is moving very quickly for the benefit of patients with colorectal cancer, and we were interested in assembling a multidisciplinary team that consisted of medical oncologists, surgical oncologists, radiation oncologists, pathologists, and radiologists as well, to help us make guidelines that really summarize the most relevant up-to-date practices, based on rigorous literature review for treatment recommendations for advanced metastatic colorectal cancer. Brittany Harvey: Great. And then as you just mentioned, this guideline provides recommendations, and a lot of those focus on areas of uncertainty in the treatment of metastatic colorectal cancer. And I'd like to review those key recommendations that you mentioned for our listeners. So, Dr. Eng, starting with - for patients with previously untreated, initially unresectable metastatic colorectal cancer, who are candidates for chemotherapy plus bevacizumab, is doublet or triplet cytotoxic chemotherapy recommended? Dr. Cathy Eng: For treatment-naive patients, bevacizumab has been approved, and we do agree that it's a very reasonable treatment option with doublet or triplet therapy for our patient population. Obviously, these are guidelines, and it's extremely important to keep in mind that as a provider, you need to discuss the potential side effects with the patient. With bevacizumab, you know, standard concerns must be discussed with the patient, especially in regards to wound healing, if they've had recent surgery or any potential risk factors for a recent cardiac event from a recent thrombosis. So, those things obviously, would preclude the patient from initiating treatment with bevacizumab. But currently, doublet therapy or triplet therapy could be a potential option for patients. Brittany Harvey: Great. And yes, as you mentioned, shared decision-making is paramount to these decisions. So then following that recommendation, Dr. Morris, which patients should be offered pembrolizumab in the first-line setting? Dr. Van Morris: Yeah. So, I think that this represents really one of the exciting advances in the treatment of metastatic colorectal cancer over the past several years. We have great data now that suggests for patients with microsatellite instability-high metastatic colorectal cancer, especially who have not had any prior treatment, we would recommend use of immune checkpoint blockade therapies, really coming from the seminal KEYNOTE-177 trial. This was a phase III international trial that looked at patients with advanced unresectable or metastatic colorectal cancer. And patients were either randomized to pembrolizumab monotherapy, or cytotoxic chemotherapy with FOLFOX, with or without bevacizumab. And this trial did meet its primary endpoint and showed an improvement in progression-free survival, with use of pembrolizumab as a single agent relative to cytotoxic chemotherapy. And based on this trial and the clear benefit that we see in patients with pembrolizumab, the FDA has approved this as an option for patients with MSI-high untreated metastatic colorectal cancer. There are other trials which have looked at use of immunotherapy; the CheckMate 142 trial looked at combination PD-1 CTLA-4 therapy as a single-arm study. And, you know, there's another trial, the CheckMate 8HW, which is looking at one versus two immunotherapy agents in this setting as well. But really, as it stands for now, patients with MSI-high untreated metastatic colorectal cancer are the ones who benefit from the use of immunotherapy. One of the questions that we often get in talking with other clinical oncologists is the FDA approval for pembrolizumab in any cancer type for a TMB, tumor mutation burden, greater than 10. And, we talked about this with our panel in this context, and we don't see that patients with microsatellite-stable metastatic colorectal cancer, who have a tumor mutation burden over 10 benefit from use of immunotherapy. There is one exception to this for patients who harbor pathogenic POLE or POLD1 mutations, these patients oftentimes do experience sustained clinical benefit with immunotherapy. But in general, patients with microsatellite-stable metastatic colorectal cancer, who don't have POLE/POLD1 mutations, we don't favor use of immunotherapy in that context at this point in time. Brittany Harvey: Great. Thank you for reviewing that recommendation and the data behind who benefits and who doesn't benefit from immunotherapy in this setting. So then following that, the next question that this guideline addressed is for treatment-naive RAS-wild type metastatic colorectal cancer. So, for these patients, Dr. Eng, is anti-EGFR therapy recommended for patients with right or left sided primary tumors? Dr. Cathy Eng: That is such an important question, and thank you for asking this. We know based upon pivotal data from CALGB/SWOG 80405, that right-sided tumors treatment-naive, even if they're RAS-wild type, these patients should not receive anti-EGFR therapy. But also, we've learned from 80405, FIRE-3, and PEAK, which was a phase two study, that there appeared to be some benefit versus anti-VEGF therapy for left-sided tumors based upon studies that have been conducted. So, at this year's ASCO, actually, the PARADIGM trial was specifically a phase III trial, more focused on left-sided tumors. It was amended twice before it decided to focus on the left-sided patient population. And it was a phase III study where patients were randomized to FOLFOX plus panitumumab versus FOLFOX and bevacizumab. And the primary endpoint was overall survival. And we added this data to our guidelines. This data just came out, hot off the presses in June, at this year's ASCO. And the primary endpoint was fulfilled. And basically, it prospectively demonstrated that the data from the other three trials, based upon a pooled analysis, suggested left-sided tumors fare better with anti-EGFR therapy. And in fact, the PARADIGM trial basically validated those findings. Obviously, the PARADIGM trial just recently presented, we have not seen the final publication, we do not know much about the maintenance setting, but specifically, when thinking about anti-EGFR therapy, it is very reasonable to consider it in a left-sided tumor, all RAS-wild type patient population. I would like to mention though, and we do highlight this also in the guidelines, which is critically important, is that there was another study, which is a phase III trial called, TRIPLETE, that was presented as well, looking at FOLFOXIRI plus panitumumab versus basically, standard treatment. And what it noted is that there is no additional benefit for FOLFOXIRI plus panitumumab in left-sided tumors in regards to response or progression-free survival, there was no additional benefit. So, FOLFOX plus panitumumab seems very reasonable, FOLFOXIRI plus panitumumab is not necessarily needed in left-sided tumors. Brittany Harvey: Great. Thank you for that explanation, and also for the work of the panel to rapidly include this new information recently presented at ASCO. So then following those recommendations, Dr. Morris, what recommendation did the panel make for patients with previously-treated metastatic colorectal cancer with a BRAF V600E mutation? Dr. Van Morris: Yeah. So, this recommendation was made essentially based on one randomized phase III clinical trial, which reported out about three years ago now, the BEACON trial. This is looking at patients with BRAF V600E mutated metastatic colorectal cancer, which we know accounts for probably eight to 10% of all patients with advanced colorectal cancer, and when found, really harbors a poor prognosis relative to BRAF-wild type counterparts. So, the BEACON trial was a trial that looked at patients with previously-treated metastatic colorectal cancer, who have BRAF mutations, either kind of standard of care cytotoxic chemotherapy, or a BRAF/EGFR combination with encorafenib and cetuximab or alternatively, a BRAF/EGFR/MEK combination. That trial showed that improvement in survival outcomes with a BRAF/EGFR-targeted approach, as well as the BRAF/MEK/EGFR. However, because there was no difference in survival with the addition of the MEK inhibitor, the FDA subsequently approved encorafenib and cetuximab as the recommended treatment for patients with BRAF V600E previously-treated metastatic colorectal cancer. Because the MEK combination with binimetinib was not recommended by the FDA, you know, we did not include that analysis in our guidelines for ASCO. But as it stands right now, we do strongly encourage all clinicians to check for their BRAF V600E mutation status in their patients with metastatic colorectal cancer, with the goal of getting them to a targeted therapy approach over their treatment course. Brittany Harvey: Great. Thank you for providing that information. So, following that, Dr. Eng, what are the recommendations for patients with colorectal peritoneal metastases? Dr. Cathy Eng: The current recommendations for colorectal cancer with peritoneal disease, really, there's no strong evidence to support the role of heated intraperitoneal chemotherapy. We now know based upon the literature from one of the largest studies to date, the PRODIGE data, demonstrating that there may be some potential benefit from cytoreductive surgery for the patients in regards to overall survival. But these patients are at high risk for bowel obstruction, potentially for perforation, and obviously, quality of life is an issue. So, these patients should always be discussed in a multidisciplinary tumor board whenever possible, and hopefully, to meet with a surgeon that is more experienced, specifically, in treating peritoneal disease, because these patients do require a lot of multidisciplinary care and discussion. So currently, based upon the existing data, we don't recommend heated intraperitoneal chemotherapy, but there may be a role for cytoreductive surgery. Brittany Harvey: Thank you, Dr. Eng for going over those recommendations. So then following that, Dr. Morris, for patients with unresectable liver-limited metastatic colorectal cancer, which liver-directed therapies are recommended? Dr. Van Morris: So, this is I think a really good question and one that just like the prior question with regards to peritoneal surgery, is one that we felt was a challenging one, but a common one that we wanted to address. And specifically, I think this is an example of where level of evidence comes into the strength of recommendation. So, for patients with unresectable liver-limited metastatic colorectal cancer, we looked at the questions of, "What is the role of SBRT - stereotactic body radiotherapy, and what is the role of SIRT, which is selective internal radiotherapy?" And for both of these, we felt that the level of evidence was weak, and I think that it's very important to make note of that in assessing the recommendations. But to start with, for SBRT, we looked at one meta-analysis for patients with oligometastatic colorectal cancer, and also analyzed 18 non-randomized control trials in this setting. Most of the patients in these studies had one to five liver metastases, with the majority having one or two liver metastases. From the meta-analysis, we saw kind of a one-year local control rate of around 67%, a two-year control rate of 59%. So, based on those and recognizing the limitations of non-randomized trials and making recommendations, the panel did feel that it was reasonable to consider use of SBRT for oligometastatic colorectal cancer. The SABR-COMET trial is one that had looked at the role of radiotherapy for treatment of oligometastatic colorectal cancer, and I just want to make the point as well, that we did not include that in our analysis or recommendations at this point in time, because this really didn't include a lot of patients with colorectal cancer that we felt warranted inclusion. Now, with regards to SIRT, we looked at kind of one meta-analysis and three randomized control trials for patients with mostly liver-limited metastatic colorectal cancer. All patients had liver disease, but there were about 40% of the patients we looked at in the meta-analysis, had extra hepatic disease as well. In the frontline setting, there really was no difference in progression-free survival or overall survival with the use of SIRT. And more recently, we've seen in a second-line trial, it was called the EPOCH trial, reported several years ago, this looked at patients with previously-treated metastatic colorectal cancer in the second-line setting. Patients were randomized to either chemotherapy with, or without transarterial radioembolization with Y90. While there was an improvement in overall response rate, there was no meaningful improvement in overall survival with the use of SIRT. But there were significant increases in grade 3 or grade 4 toxicities when SIRT was added to chemotherapy. So, kind of given this, we didn't feel at this point in time that SIRT should be recommended for patients with metastatic colorectal cancer. Although, again, I do want to highlight that really these discussions should be happening at high-volume centers, kind of with a multidisciplinary group of clinicians. Brittany Harvey: Definitely. And thank you for highlighting that multidisciplinary collaboration. And the last section of recommendations, Dr. Eng, what is recommended for patients with metastatic colorectal cancer, and potentially-curable oligometastatic liver metastases? Dr. Cathy Eng: So, another controversial topic. And once again, this is why we decided to include this as part of the guidelines, because this is a common scenario where patients are potentially curable, following liver resection for oligometastatic disease. We cannot highlight enough the importance of multidisciplinary discussion. Prior data has not been strong regarding specific guidelines following liver resection. We do recommend that based upon the existing data, there is no level one evidence to say, you should go one way or another following metastatic resection, and whether or not adjuvant therapy is warranted in that setting. But we do recommend multidisciplinary management and engagement and discussion. So, although it's not definitive, it basically suggests that there is a role for resection. It does provide improved five year survival relative to systemic chemotherapy, if the patient is potentially resectable, but does require multidisciplinary discussion. And it is a shared decision-making process. Brittany Harvey: Great. Thank you. And I appreciate you highlighting the importance of shared decision-making throughout this guideline. So then, Dr. Morris, what is the importance of this guideline in your opinion, and how will it impact clinical practice? Dr. Van Morris: Yeah. So, I think that we understand that management of metastatic colorectal cancer is extremely complex given the various molecular annotations and the multimodality therapies which are possible for our patients. So, we tried to limit the guidelines here to include what we feel are the most recent updates, but also kind of the most clinically-relevant multidisciplinary questions that get asked for treatment of metastatic colorectal cancer. We also recognize that things are changing quickly. And for example, we didn't decide to include at this point in time, management of HER2 neu amplified metastatic colorectal cancer, although we are seeing more and more data coming out, suggesting targeted therapies. So, I think it's important for clinicians to realize that these are guidelines which are ever-changing, given the updates with new therapies available for our patients. And the other thing I think that's very good about these guidelines is that, even though we may be making recommendations about controversial topics in the management of metastatic colorectal cancer - specifically, I think the use of HIPEC with cytoreductive surgery, locally-directed therapies to the liver, and the role of perioperative chemotherapy and metastasectomy - I think it's important for oncologists to realize that these recommendations come with varying strengths of level of evidence and that we as oncologists should be considering the level of evidence that's out there when making recommendations that affect our patients as well. So, we really wanted to support these guidelines and recommendations and empower clinicians to know and understand the quality of evidence that exists in the management of patients with metastatic colorectal cancer. Brittany Harvey: Excellent. And yes, those are key points on the level of evidence and the strength of recommendations throughout the guideline. And then finally, Dr. Eng, you've talked a bit about shared decision-making and the importance of this guideline for patients. So, how will these guideline recommendations affect patients with metastatic colorectal cancer? Dr. Cathy Eng: The reason that we created these guidelines is to help patients, their caregivers, and providers, learn of the most recent developments in colorectal cancer, and the best approach based upon the information that we have personally reviewed with our multidisciplinary team of faculty members that participated in this exercise. We really just want to make sure that patients do get optimal care. And we hope that these guidelines also will help provide a foundation for some of the clinical trials that may be under development, or for other clinical trials that are being considered. So, we really just want to provide the most up-to-date information to all individuals that are interested in colorectal cancer so we can help guide their care better. Brittany Harvey: So, I want to thank you both so much for your work on these guidelines, and all of the time it's spent developing these recommendations, and thank you for your time today, Dr. Morris, and Dr. Eng. Dr. Van Morris: Thank you. Brittany Harvey: And thank you to all of our listeners for tuning into the ASCO Guidelines Podcast series. To read the full guideline, go to: www.asco.org/gastrointestinal-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app available in iTunes or the Google Play store. If you have enjoyed what you've heard today, please rate and review the podcast, and be sure to subscribe, so you never miss an episode.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy, should not be construed as an ASCO endorsement.  

Tá post mar Oifigeach Turasóireachta á thairiscint sa Díseart sa Daingean ar chonradh dhá bhliain, maoinithe ag Údarás na Gaeltachta.

When it comes to maintaining that youthful luster, we have, over the years, concocted all manner of things - from cosmetics, dietary plans, and exercise regimes - to get the job done. But unless you've got the actual fountain of youth in your back garden or the holy grail sitting on your mantle you're probably plum out of luck when it comes to reversing the aging process completely. That being said, researchers at the University of Rochester have uncovered more evidence that the key to longevity resides instead with a simple enzyme. Vera Gorbunova, Professor of Biology and Medicine & co-director of the Rochester Aging Research Center at the University of Rochester joins Jonathan to discuss. Dr.Ruth Freeman from the SFI & Shane Bergin, Physicist & Assistant Prof in Science Education at UCD also joined Jonathan for Newsround.

Nukleotydy to związki niezbędne do prawidłowego funkcjonowania organizmu. Są potrzebne do budowy nici DNA i RNA, naprawy nici DNA, prawidłowego rozwoju mózgu i sprawności umysłowej, pracy układu odpornościowego oraz pokarmowego. Biorą udział w metabolizmie energetycznym komórki, mają wpływ na mitochondria i obronę antyoksydacyjną. Dlatego też są niezbędne do życia. Z dzisiejszego odcinka dowiesz się:- czym są nukleotydy, a czym nukleozydy?- dlaczego mleka modyfikowane dla niemowląt są wzbogacane o nukleotydy?- czy suplementacja nukleotydów jest konieczna? jeżeli tak, to kto skorzysta?- jakie są naturalne źródła nukleotydów?Zapraszam do słuchania. Dziękuję Patronom i Patronce za wspieranie podcastu: Aleksander, Krzysiek, Jordan, Teresa.Przypominam, że wystartował mój bezpłatny mini-kurs "Poznaj i napraw 4 błędy w odchudzaniu, przez które nie chudniesz". Jeżeli masz za sobą wiele prób odchudzania, chcesz uwolnić się od restrykcyjnych diet i chcesz poprawić relację z jedzeniem, to ten kurs jest dla Ciebie! Podczas kursu poznasz i nauczysz się jak naprawić kluczowe 4 błędy w odchudzaniu, które:- sabotują Twoje wysiłki w procesie odchudzania,- sprzyjają efektowi jojo,- zaburzają relację z jedzeniem.Jeżeli chcesz dowiedzieć się więcej zapraszam na stronę: https://pielichowska.pl/bezplatny-mini-kurs/Jeżeli masz pytania do tego odcinka napisz do mnie na malgorzata@pielichowska.pl Odwiedź moją stronę: https://pielichowska.pl/blogZapisz się do newslettera: https://pielichowska.pl/podcast (na dole strony)Zostań moim Patronem: https://patronite.pl/pielichowska Odwiedź mojego Facebooka: https://www.facebook.com/pielichowska.dietetyk Odwiedź mojego Instagrama: https://www.instagram.com/gosia.pielichowska/ LinkedIn: https://www.linkedin.com/in/pielichowska Partnerem podcastu "Gosia Pielichowska" jest #MentalPower, marka założona przez Jakub B. Bączek: trenera mentalnego olimpijczyków i przedsiębiorcę, z którym miałam przyjemność prowadzić rozmowę na temat sensu życia w 55. odcinku podcastu. MentalPower prowadzi Akademię Trenerów Mentalnych, czyli studium treningu mentalnego przygotowujące do zawodu, jakim jest Trener Mentalny. W ramach Akademii, zajęcia prowadzą między innymi: Jakub B. Bączek, Daniel Janik, Tomasz Kammel czy Stephane Antiga. Możesz się zastanawiać: czym jest trening mentalny? Trening mentalny polega na psychicznym przygotowaniu człowieka do wyzwań, którym stawia czoło. Dzieje się to między innymi poprzez wizualizację. Trening mentalny stosowany jest wśród sportowców, przedsiębiorców, a nawet lekarzy przygotowujących się do trudnej operacji. Ja również, jako dietetyk i psychodietetyk wykorzystuję w swojej pracy trening mentalny, a konkretnie kontrastowanie mentalne z implementacją intencji, co możesz kojarzyć z 14. odcinka podcastu. Dzięki współpracy z MentalPower, słuchacze podcastu mogą skorzystać z kodu, który uprawnia do zakupu całego szkolenia w ramach Akademii Trenerów Mentalnych z 30% rabatem! Co ważne, zniżkę możesz wykorzystać niezależnie od tego, czy płacisz za szkolenie w całości, czy zdecydujesz się na płatność w ratach.Szczegóły, jak wykorzystać kod:Wejdź na stronę www.jakubbbaczek.pl/sklep/atm23-raty/Po kliknięciu przycisku „dodaj do koszyka” zostaniesz przekierowany_a na stronę „Koszyk”.By uzyskać rabat, wpisz „ATMGOSIA” w okienku „Kod kuponu” oraz zatwierdź przyciskiem „Zastosuj kupon”.Dziękuję #MentalPower za wspieranie podcastu, a słuchaczom za zaangażowanie!

In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. Raul Mostoslavsky, the Laurel Schwartz Professor of Oncology at Harvard Medical School. Dr. Raul Mostoslavsky has studied sirtuin functions in cancer for many years and has identified a pathway responsible for tumor growth in 30% to 40% of pancreatic cancer patients and more recently identified metabolism as a heterogeneous feature of cancer. Dr. Raul Mostoslavsky discusses the role of sirtuins in aging and explains how the mechanisms that protect us from cancer may also preserve our longevity on a cellular level.To learn more about science-backed ways to live a healthier, longer life, download InsideTracker's InnerAge eBook at insidetracker.com/podcast

Jill Cruz, MS, CNS helps women over 40 who hate dieting to lose weight and feel great without being deprived. Jill has a Master of Science degree in Human Nutrition, and she is a Board Certified Nutrition Specialist and a Certified Big Leap Coach. Jill combines her strong science-based background with tons of practical nutrition, fitness, and lifestyle guidance, helping people strive to be the best versions of themselves. She is on a mission to guide women to achieve their wildest dreams for their health while loving the food they eat and the life they live. Episode Notes: SIRT Foods: plant nutrients that only occur in plant foods. They stimulate sirtuin genes in the body to help the body burn food and build muscle. What is nutrition? It encompasses so much more than just the food you eat. Sunlight exposure, sleep, spirituality, and mental health all affect our nutrition. The importance of iron-rich foods for women before and during the menstruation. Understanding how FAD diets work and how to build healthy relationships with food. Learn natural sources to obtain umami from foods. The difference between Food Addictions and Eating Disorders. Learn how to reduce your cravings by about 50% and the complexities of habitual cravings. The importance of honoring and respecting emotions linked to food. How to build healthy habits regarding nutrition and your movement. Connect with Jill Cruz: Facebook: https://www.facebook.com/wynweightloss Facebook Group: https://www.facebook.com/groups/healthyhappyweightlosssisterhood Linkedin: https://www.linkedin.com/in/jill-cruz-ms-cns-01ba3649/ Instagram: https://www.instagram.com/wyn_weight_loss/ Twitter: https://twitter.com/JillCruz1 _________________________________________________________ Connect with Farrah La Ronde-Hutchison @gaiatarian Website: https://bit.ly/2ZE6dKo Instagram: https://bit.ly/3CwE6eM YouTube:https:https://bit.ly/30dZNlA Podcast: https://anchor.fm/beastmamas

SIRT has reviewed the final moments of NS Mass Shooter Gabriel Wortman's killing spree, when he was shot dead by two RCMP officers at the Irving Big Stop in Enfield at 11:25am on April 19, 2020. To almost nobody's surprise, SIRT has cleared the officers of any wrongdoing in the incident, which brought to an end a terrifying ordeal for the people of central Nova Scotia and beyond. Reviewing the SIRT report and further evidence uncovered since that time does not detract from the skill and mettle of these two officers in those critical moments, but does raise questions about what was known to SIRT when the report was written, and also about possible connections between Wortman and the police. The SIRT report notes that Wortman stopped for gas at the Big Stop, and that two Emergency Response Team officers coincidentally stopped at the same time, on the opposite side of the same pump. The report states that one officer saw that the man in the car was bleeding and recognized him as Wortman, exited his police vehicle “to begin refueling”, saw Wortman reach for a gun, and opened fire. It all sounds like something out a movie, but the vague language used by former Justice Cacchione may also have the effect of concealing some details we have come to know from other sources. Reliable sources have provided media with details of police radio traffic, and we have been able to see the actual video of the Big Stop shooting, as well as Wortman encountering the police just minutes prior to the Big Stop shooting at a gas station down the highway in Enfield. Collectively, these additional details significantly change the narrative of the final moments of Wortman's killing spree. A mass shooter, who clearly intended to keep killing, was stopped with no further loss of life at a very public location. From that perspective, things could be said to have worked out very well at the Big Stop. The question is whether any planning took place in the 4-5 minutes Wortman took to get from the Petro-Canada to the Big Stop, and whether those plans or instructions included orders to kill on sight rather than risk trying anything else. What we have is an organized effort made to craft a story that does not seem to need crafting. That in itself lends credibility to the doubtful. The SIRT report covers the final moments of the NS Mass Casualty event, and perhaps because of the more narrow focus of SIRT, coupled with the fact that Wortman was the victim affected the conclusions. The Mass Casualty Commission should delve into these details so that we can learn how our police prepare for and deal with these scenarios, and why they have chosen to conceal or obfuscate some of the mass shooting's final moments.

Just after 10am on April 19, 2020, with the Nova Scotia mass shooting killer still on the loose, having left Portapique 12 hours earlier and having committed further killings in the Wentworth area, two RCMP officers erroneously fired multiple shots at a fellow officer and a civilian emergency responder at the Fire Hall in Onslow. Such incidents draw investigations by the Serious Incident Response Team (SIRT), which is designed to review police shootings to see whether charges may be warranted against an officer. SIRT is civilian-led, and independent from the police or government. SIRT is now led by retired NS Supreme Court Justice Felix Cacchione, and has a team of investigators made up of former and current police officers. The SIRT report states that two officers drove up to the Onslow Fire Hall in an unmarked Nissan Altima, saw a person they thought was Gabriel Wortman standing next to a marked RCMP car while wearing a high visibility orange and yellow vest, yelled to him to show his hands, and then shot when the person instead ducked behind the police car. Credible eyewitness reports describe a situation where there was either a sudden, panicked (or at least not cool-headed) reaction to seeing someone who might be the killer, or else one where the officers were deliberately fooled into thinking it was Wortman standing outside the Fire Hall. If it was the former, these officers are in the wrong line of work, and the SIRT report is flawed. If it is the later, then there is potentially much more to uncover about Wortman's relationship with the RCMP.

När Muammar Gaddafi dödades bar han en guldpistol. Han stödde terrorgrupper, festade med Berlusconi och hade en kvinnlig livvaktsstyrka. Hör om Gaddafis arv och kaoset i Libyen tio år efter hans död. Libyen styrdes av Muammar al-Gaddafi i mer än 40 år. Han förstatligade oljan och ökade landets välstånd och lanserade en egen politisk filosofi i skriften "Den gröna boken". Gaddafi var känd för sin excentriska klädstil och att han till exempel reste sitt eget beduintält på internationella möten. Men han anklagades också för att stödja flera internationella terrordåd, som då ett plan sprängdes i Lockerbie och 270 personer dog. Efter attacken var Libyen internationellt isolerat och under sanktioner. Gaddafis regim kritiserades upprepade gånger för att bryta mot mänskliga rättigheter och kväsa opposition. Under den arabiska våren slog Gaddafis styrkor till hårt mot alla motståndare. Han tillfångatogs och dödades av rebeller hösten 2011. Libyen efter GaddafiDe senaste tio åren har präglats av maktstrider och kaos, vid en punkt hade Libyen tre rivaliserande regeringar. Krigsherrar, klaner och rebellgrupper tävlar om inflytandet. Julafton 2021 hålls val,  många hoppas att det ska bli en väg ut ur röran men det ryktas också att en av Gaddafis söner försöker göra politisk comeback. Om Muammar al-Gaddafi:Född 1942 nära Sirt i Libyen.Tog makten vid en militärkupp 1969.Har tio barn, den mest kända är sonen Saif al-Islam. Flera barn dödades under upproret i Libyen.Efter att Libyen betalade ut kompensation för Lockerbie-attentatet hävdes landets isolering gradvis.Medverkande: Cecilia Uddén och Johan Mathias Sommarström, Sveriges Radios MellanösternkorrespondenterProgramledare: Johar BendjelloulProducent: Katja MagnussonTekniker: Gardar Hansen

Can we actually activate the "skinny gene" in our bodies? The SIRT Food Diet helped Adele with her 100-pound weight loss and keeps Boxer Conor McGregor lean and mean. This episode will highlight the SIRT Diet that claims to help reduce body weight, prevent inflammation and disease, increase muscle mass, and slow the signs of aging.PRODUCER & HOST ANNE MCDANIELS LINKS:Facebook: Anne McDanielsFacebook: Anne McDaniels ActressInstagram: @annemcdanielsactressInstagram: @annemcdanielsTwitter : @annemcdanielsIMDB : Anne McDanielsClubhouse: @annemcdanielsTikTok: Anne McDanielsClubhouse: @annemcdanielsMusic Credit: ""Light" - JoeninpcGamer ; Royalty Free MusicPhoto Credit: DrKellyAnn.com; Express.co.uk; UFCSources: Healthline; SportsJoe; GourmetSleuth; Dr. Oz; Tasty; Nourishable; Tasty; Dr. Kellyann Petrucci; Entertainment Tonight; VogueSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

https://go.dok.community/slack https://dok.community/ ABSTRACT OF THE TALK Prima and Tammy join us to discuss the bridges between Security and SRE. How can these two teams work best together? What can they learn from each other? Prima is a Security Engineer and Tammy is a Site Reliability Engineer. They are both Australians living in the USA with 10+ years of experience each working in tech. TALK TAKEAWAYS 1.You'll learn tips for SRE and Security teams to work together 2.You'll learn what SREs can learn from Security and vice versa 3.You'll learn about the new field of DevSecOps and how it can help your organisation improve BIO Tammy Bryant Butow is a principal SRE at Gremlin, where she works on chaos engineering—the facilitation of controlled experiments to identify improvements. Gremlin's enterprise Chaos Engineering platform makes it easy to build more reliable applications in order to prevent outages, innovate faster, and earn customer trust. Previously, Tammy led SRE teams at Dropbox responsible for the databases and storage systems used by over 500 million customers and was an IMOC (incident manager on call), where she was responsible for managing and resolving high-severity incidents across the company. She has also worked in infrastructure engineering, security engineering, and product engineering. Tammy is the cofounder of Girl Geek Academy, a global movement to teach one million women technical skills by 2025. Tammy is an Australian and enjoys riding bikes, skateboarding, snowboarding, and surfing. She also loves mosh pits, crowd surfing, metal, and hardcore punk. Prima is a seasoned Security professional who has worked in a variety of industries such as Consumer Tech, Oil & Gas, Media, and Fin-tech. She is a Senior Security Engineer on the SIRT team at Segment where she enjoys creating automation tooling for Incident Response and occasionally dabbles in Security DevOps. She loves sharing her experiences with the industry and has spoken at many meetups and conferences globally including, but not limited to, Agile India 2020, MacDevOpsCon Vancouver 2019, and Grace Hopper Conference 2017.

Business Channel Tv'de yayınlanan VEDAT HOCA ile SPORA DAİR HER ŞEY programı sizlerle... Vedat Çamak, bu hafta bacak egzersizi ile sırt egzersizi hakkında bilinmesi gerekenleri uygulamalı olarak siz değerli seyircilerimiz için anlattı. Bu yayını kaçırmayın... #bacakegzersizi #sırtegersizi #spor

The province's Serious Incident Response Team is investigating allegations of sexual assault in the RNC. We talk to the director, Mike King.

Multiple BaseXX Obfuscations https://isc.sans.edu/forums/diary/Multiple+BaseXX+Obfuscations/27640/ Juniper Patches: Radius Vulnerability https://kb.juniper.net/InfoCenter/index?page=content&id=JSA11180&cat=SIRT_1&actp=LIST fail2ban vulnerability https://github.com/fail2ban/fail2ban/security/advisories/GHSA-m985-3f3v-cwmm NSO Group Victims Leaked https://www.amnesty.org/en/latest/research/2021/07/forensic-methodology-report-how-to-catch-nso-groups-pegasus/ Dangers of Autofilling Passwords https://marektoth.com/blog/password-managers-autofill/#analysis

Multiple BaseXX Obfuscations https://isc.sans.edu/forums/diary/Multiple+BaseXX+Obfuscations/27640/ Juniper Patches: Radius Vulnerability https://kb.juniper.net/InfoCenter/index?page=content&id=JSA11180&cat=SIRT_1&actp=LIST fail2ban vulnerability https://github.com/fail2ban/fail2ban/security/advisories/GHSA-m985-3f3v-cwmm NSO Group Victims Leaked https://www.amnesty.org/en/latest/research/2021/07/forensic-methodology-report-how-to-catch-nso-groups-pegasus/ Dangers of Autofilling Passwords https://marektoth.com/blog/password-managers-autofill/#analysis

Dietician Professor Clair Collins gives this celebrity diet expert analysis. UK Singer Adele claimed it transformed her (along with Pilates and a personal trainer). The diet is based on a group of proteins called "Sirtuins". Adele sang its praises but is Sirt-food a fad, a fact or something in-between? the conversation    

Mike King Director SIRT-NL Responding to First Voice's Working Group on Police Oversight by VOCM

Skeat recebe Nappon e SirT para falar sobre o #MSI2021 - especialmente, sobre a paiN Gaming, representante do #CBLOL no torneio na Islândia, e os adversários diretos na luta pela classificação.

There's a perception that police are investigating police when matters are referred to the Serious Incident Response Team. Nova Scotia put a retired judge in charge of the team but still relies on seconded officers to carry out investigations. Would following BC's model alter the perception?

The Serious Incident Response Team (SIRT) was asked to investigate whether there was criminal misconduct by police during the period before the appeal of Glen Assoun's conviction. He's the Nova Scotia man who spent 17 years in prison for a murder he didn't commit. Former SIRT director Ronald J. MacDonald is heading up this investigation with his current team of The Independent Investigations Office of British Columbia (IIOBC). And of note, unlike SIRT in Nova Scotia, the IIOBC team is made up entirely of civilian members.

Das Frühjahr steht vor der Tür, und die Corona-Pfunde sollen weg. Diäten erleben gerade jetzt den absoluten Mega-Hype. Aber welche Art von Ernährungsumstellung ist gut für Dich, und von welchen Diäten solltest Du besser die Finger lassen? Im Podcast bewerten Thorsten und Alex die neuesten Ernährungstrends, und diesmal ist die SIRT-Diät an der Reihe. Dabei wird mit einer Art "Turbo-Booster" der Stoffwechsel angeregt, wodurch überflüssigen Pfunde angeblich ganz schnell dahinschmelzen. Wie das funktioniert, und warum sogar Rotwein und Schokolade erlaubt sind, das erfährst Du in dieser Episode.

Nova Scotia’s independent police watchdog, the Serious Incident Response Team (SIRT), has concluded two RCMP officers who shot at the fire hall in Lower Onslow, N.S., during the manhunt for Gabriel Wortman should not face criminal charges. The SIRT report said the two officers who fired their weapons did so believing the person they were shooting at was the gunman. This is because he was dressed similarly to the gunman — wearing a yellow and orange reflective vest — and standing near a marked RCMP cruiser at the time of the shooting. In this bonus episode, producers Sarah Ritchie and Alex Kress bring you the breaking news and explain what new information is in the SIRT report. We also hear reaction once again from the firefighters who say the police “terrorized” them on April 19, and have never apologized.   We have much more on our website, including articles, maps, and photos: globalnews.ca/13hours Instagram: @13hourspodcast Email: 13hours@curiouscast.ca Twitter: @SarahRitchieTV; @alexandrakress See omnystudio.com/listener for privacy information.

Old Tricks still work: I love you Malspam https://isc.sans.edu/forums/diary/Heartbreaking+Emails+Love+You+Malspam/24512/ Juniper Updates Released https://kb.juniper.net/InfoCenter/index?page=content&id=JSA10916&cat=SIRT_1&actp=LIST https://kb.juniper.net/InfoCenter/index?page=content&id=JSA10918&cat=SIRT_1&actp=LIST New Systemd/Journald Exploit Release https://www.qualys.com/2019/01/09/system-down/system-down.txt Global DNS Hijacking https://www.fireeye.com/blog/threat-research/2019/01/global-dns-hijacking-campaign-dns-record-manipulation-at-scale.html

Large Number of Credentials Offered For Sale http://www.reuters.com/article/us-cyber-passwords-idUSKCN0XV1I6 Alphalocker: Affordable Ransom Ware https://blog.cylance.com/an-introduction-to-alphalocker JAKU Botnet https://www.forcepoint.com/sites/default/files/resources/files/report_jaku_analysis_of_botnet_campaign_en_0.pdf Juniper Update http://kb.juniper.net/InfoCenter/index?page=content&id=JSA10734&cat=SIRT_1&actp=LIST

OS X Memory Forensics https://isc.sans.edu/forums/diary/An+Introduction+to+Mac+memory+forensics/20989/ Facebook App Used to Delivery Facebook Phish http://news.netcraft.com/archives/2016/04/22/hook-like-and-sinker-facebook-serves-up-its-own-phish.html Android.Spy.277.origin Keeps Being Delivered By Google Play Store Apps http://blog.checkpoint.com/2016/04/22/in-the-wild-google-cant-close-the-door-on-android-malware/ Tool To Replay RDP Sessions From pcaps http://www.contextis.com/resources/blog/rdp-replay-code-release/ Juniper Update http://kb.juniper.net/InfoCenter/index?page=content&id=JSA10727&cat=SIRT_1&actp=LIST RouterSploit Router Exploit Framework https://github.com/reverse-shell/routersploit