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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.26.268649v1?rss=1 Authors: Kato, K., Ahmad, S., Zhu, Z., Young, J., Mu, X., Park, S., Malik, H., Hur, s. Abstract: RNA helicases and ubiquitin E3 ligases mediate many critical functions within cells, but their actions have been studied largely in distinct biological contexts. Here, we uncover evolutionarily conserved rules of engagement between RNA helicases and tripartite motif (TRIM) E3 ligases that lead to their functional coordination in vertebrate innate immunity. Using cryo-electron microscopy and biochemistry, we show that RIG-I-like receptors (RLRs), viral RNA receptors with helicase domains, interact with their cognate TRIM/TRIM-like E3 ligases through similar epitopes in the helicase domains. Their interactions are avidity-driven, restricting the actions of TRIM/TRIM-like proteins and consequent immune activation to RLR multimers. Mass-spectrometry and phylogeny-guided biochemical analyses further reveal that similar rules of engagement apply to diverse RNA helicases and TRIM/TRIM-like proteins. Our analyses thus reveal not only conserved substrates for TRIM proteins but also unexpectedly deep evolutionary connections between TRIM proteins and RNA helicases, thereby linking ubiquitin and RNA biology throughout animal evolution. Copy rights belong to original authors. Visit the link for more info
The Field is a new initiative from Psyonix that will give Rocket League on of the clearest ramps into becoming an esports professional. With three divisions under the RLRS, there are now five different leagues offering promotion and relegation to reach the top level. In addition to The Field, Psyonix is also hinting at a major announcement for RLCS S10 (RLCS X) but, as of publishing, that announcement hasn't been released. Stay tuned to the Esports Minute for that announcement that week. If you enjoyed the podcast, please rate and subscribe! New episodes Monday through Friday. For more in-depth news check out our bi-weekly podcast The Esports Network Podcast (https://www.esportznetworkpodcast.com/). Follow Mitch on Twitter @Mitch_Reames (https://twitter.com/Mitch_Reames) Follow Esportz Network on Twitter (https://twitter.com/EsportzNetwork), Instagram (https://www.instagram.com/esportznetwork/), and Facebook (https://www.facebook.com/EsportzNetwork) @EsportzNetwork Or visit our website esportznetwork.com (https://www.esportznetwork.com/) for updates on what's to come!
(Time stamps below) Hear our Rocket League teams aspirations as they have an open discussion with ex-Endpoint and Vitality coach Gregan! 0:00 Introductions 1:00 What do you enjoy about Metsanauris from the trial so far? 1:50 What was it like for you guys when you were doing so well from the off in RLRS? 2:30 Whats it like to go from bubble players with not much experience to top players? 4:20 Whats Metsanauris mindset and attitude like in practice? 5:50 Virtuoso, how much do you play the game? 7:00 Do you think 6 mans helped you get recognized? 10:10 Talk us through how Endpoint has helped and the bootcamps you have done? 11:45 How different is practicing on bootcamp to online? 15:00 How is it balancing RL,school and life? 19:55 What do you think your new playstyle will be like with Metsanauris? 22:50 Whats the aim for the team? 27:00 Whats the teams mindset towards health? 29:15 Whats it going to be like for the long days of Spring Series open qualifiers? 31:00 Thoughts on Spring Series? 32:30 Are national leagues good or should it be more EU based? Q&A 44:00 Why did you pick up Metsanauris? 48:20 Metsanauris: How ugly am I? 42:30 RelatingWave sharky cam (knocks on glass :D) 51:00 Thoughts on Wave being top6 in stats? 52:15 What teams are you most scared of in RLCS10? 54:40 Predictions on teams to make Spring Series main? 57:10 Thoughts on separating friend environment to work environment?
Rocket League hat sich seit seinem Erscheinen 2015 zwar als Esports-Disziplin etabliert, von regelmäßigen Turnieren mit Preisgeldern in Millionenhöhe können die Athleten allerdings nur träumen. In der neuen Folge unmuted erzählen zwei der besten deutschen Rocket League Spieler, Sandro "Freakii" Holzwarth und Maik “Tigreee” Hoffmann, was es bedeutet, Esportler für eine Disziplin abseits von League of Legends, CS:GO und Dota 2 zu sein. Was könnte sich “Rocket League”-Entwickler Psyonix von Riot Games und Valve in Sachen Esports abschauen? Was müsste passieren, damit Rocket League die Aufmerksamkeit bekommt? Und warum sind derzeit viele Spieler und Teams so unzufrieden mit der Turnierstruktur? Für mehr Infos rund um unseren Podcast, folgt uns auf Twitter (www.twitter.com/unmuted_esports) und joint unserem Discord-Server (https://discord.gg/MGbRXAj).
As the weeks roll on, so does the Bubble scene. We're covering the playoffs of all the Rising Stars League's as well as previewing some of the final standings for SuperStar League. We're also talking about some of the early moves and rumours coming out of the offseason including Mousesports, ex-REC and Triple Trouble. Timestamps: 0:00 - Intro --News-- 3:00 - Mousesports Confirm Arju as new third for Spring Series 8:34 - Singularity replace Godsmilla with Mognus for Spring Series 15:00 - Reciprocity's reported new organisation 21:39 - Scrub Killa to ex-REC rumours 30:08 - Triple Troubles tryouts --Mailbag-- 40:06 - Hutchy: For fans like myself who don't really watch any competitive Rocket League under RLRS, who are your picks for up and coming players or teams that I may have not heard of who have toe potential to burst through into RLRS or beyond? --Tournament Roundup-- 48:10 - Rising stars introduction 49:43 - Firewall Rising Stars results 50:21 - Trip ups for RJM, success for BERG 57:41 - Golden Dust Rising Stars results 59:05 - SUPRMODE and Galazy Bang lead the charge for Spanish Risers 1:00:38 - Several teams left out of the 3rd place position. Justified or format failing 1:06:38 - Rocket Baguette Rising Stars results 1:07:23 - Solary set to FF their 3rd place match. How does that affect the results? 1:13:20 - The new look Servette Geneva 1:22:28 - Milo in with WithMYBoyz, how's the new kid doing? 1:28:08 - ==Breaking== Rix Ronday officially off Triple Trouble 1:31:35 - Europa Rising Stars results 1:32:20 - Quality Control look good, can they be consistent? 1:25:05 - Are WLF relying on the Arju carry? 1:38:54 - VoiD vs JorJaJo 3rd place match preview 1:45:15 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
It may be April 1st, but we're not fooling around with the final week of the Season. It's the playoffs of the RLCS and the final week of the Rival Series, along with the conclusion of the TEI as we look to the offseason and all it might bring in the Spring. All this plus the news on Servette Geneva's roster moves, ScrubKilla speaks out about leaving Mousesports, and we answer community question as part of our Mailbag segment. Timestamps: 0:00 - Intro --News-- 1:36 - ScrubKilla speaks out on leaving Mousesports 11:04 - Psyonix announce the Rocket League Spring Series 27:58 - Yagi announces his departure from Servette Geneva 36:39 - Itachi announces he is now eligible for RLCS. Now LFT --Mailbag-- 45:05 - Intro 45:40 - Tylacto: How HYPED are you about this (Tylacto's return to regular Rocket League 51:33 - JarofJam - It doesn't seem like it can contunue like this for the Reciprocity roster. Who needs to go and why? 1:06:28 - Your thoughts on TO's, Casters, Volunteers being often treated like dogshit? 1:18:01 - A lot of the time when listening to Rocket League casters, they often say it was a great play or it was a mistake that lead to a goal. Casters will hardly say it's something in between i,e, forced error or made it awkward for defending team. What do you think the reason is for that? --Tournament roundup-- 1:28:52 - TEI results 1:29:30 - TEI discussion 1:39:42 - RLRS results 1:41:25 - RCD's questionable form 1:50:26 - WE Dem Girlz out with a Whimper 1:57:39 - BDS dominate their way to RLCS 2:02:34 - RLCS Playoffs 2:03:48 - Results 2:04:31 - Reciprocity: Disappointment of the playoffs 2:12:28 - Mousesports with nothing to lose, and they played like it 2:19:54 - FC Barcelona playing closer to their peak. What about doing that consistently? 2:24:40 - Dignitas rise to new highs 2:31:19 - Discord Pick 'em results table 2:33:40 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
It's the final week of the RLCS, and so we break down the final standings going to the Regional Playoffs. Plus the RLRS reaches its penultimate week and we've got a lot of new to break down going into the offseason. Everything is starting to kick off in the Rocket League scene, and we've got the low down. 0:00 - Intro --News-- 2:48 - ScrubKilla leaves Mousesports 19:00 - Reciprocity releases most of their staff, including RL team, due to the economic impact of coronavirus. 34:54 - Tokyo Olympics get postponed. Intel World Open under question 44:53 - Singularity pick up Jake as a coach 51:31 - Gillyweed announces her departure from Psyonix'x esports team --Tournament Roundup-- 58:44 - TEI intro 59:33 - TEI results 1:00:26 - Sandrock are overrated 1:17:15 - Singularity represent the RLCS/RS in the UB finals 1:20:55 - The first 4 teams out of the Lower Bracket 1:25:35 - Predictions for next week 1:26:53 - RLRS results 1:28:23 - RCD having a bad week. And it could cost them everything 1:32:49 - Triple Trouble secure their place into next season. RJM and WDG set for a survival clash 1:41:50 - Next weeks fixtures and predictions 1:43:37 - RLCS results 1:45:31 - On the RLCS Dress Code 1:53:05 - On the Weekly MVP awards 1:59:15 - Season MVP awards 2:04:21 - Mousesports with Arju. Did they do the damage? 2:10:25 - How did TSM manage an upset above FCB? 2:19:10 - REC show their discipline with a massive upset going out of League play 2:28:10 - Playoffs bracket and predictions 2:30:35 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
Disclaimer: We recorded this episode before the Scrub Killa news from yesterday. Some of the info in this episode is slightly outdated. We're into week 2 of lockdown, and still, the online competitions continue in Rocket League. We're breaking down the results from TEI, RLRS, and RLCS and we're having a discussion on Tech pauses in official matches, with a major PC issue hurting WeDemGirlz in the Rival Series. Timestamps: 0:00 - Intro --News-- 2:49 - Rix_Ronday disconnects during an RLRS match. Debate sparks around disconnection rules --Tournament Roundup-- 16:36 - Intro 17:21 - TEI Results 18:44 - SandRock Gaming stomping on Vitality. Is this result legit? 28:41 - FCB snuck out under by Endpoint 30:59 - Playoffs Preview 32:12 - RLRS Results 34:29 - Servette are officially out 43:35 - The clash of the titans between RCD and NLE 51:46 - TT outlive our expectations against WDG 58:00 - Next weeks matches and predictions 1:02:37 - Pick 'em leaderboard update 1:05:27 - RLCS Results 1:06:57 - Veloce must have proven themselves by now 1:11:50 - A concerning FCB this week 1:20:37 - Former RLRS clash between Singularity and Endpoint 1:27:59 - Renault Vitality, and the destruction of Mousesports 1:40:26 - Next weeks matches and predictions 1:43:07 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
It's been another tough week for RLEsports, as the Corona Virus outbreak causes the World Championship to be cancelled, and in-studio broadcasts to also be canned. We break down all that news and all the results from the big weekend of the RLCS. Timestamps: 0:00 - Intro --News-- 1:45 - Dallas LAN is cancelled due to Coronavirus concerns 14:25 - Envy speculated to return to the scene 22:05 - Remkoe tweets concerning tweets in relation to his mental health --Mailbag-- 33:02 - Intro 33:24 - Dweg: If Rocket League was to change to 4v4 in competitive play rather than 3v3, what issues would occur if any? And what would your thoughts be around that? 37:08 - Jar of Jam: A follow-up to Velixo's question - Jay and I covered the national qualifier teams for Intel Olympics, but who do yo uthink is gonna make it as the three European teams from the regional qualifiers? --Tournament roundup-- 42:59 - Intro 43:39 - TEI Results 45:00 - Notorious Legion and RCD stun their groups 50:02 - Sandrock leags the way for MENA and Asia 54:46 - Servette and WDG finally show some bite to their bark 59:10 - Reciprocity bottoming out their group so far 1:03:29 - RLRS results 1:04:36 - More big wins for NLE and RCD 1:09:47 - BDS proving the doubters wrong 1:12:33 - Next weeks matches and predictions 1:17:51 - RLCS results 1:19:36 - A lot of the expected results 1:20:52 - Dig with a close shave against FCB 1:27:41 - Veloce choking against Mousesports. What's the damage? 1:31:45 - Vitality upset on Dignitas 1:38:50 - Next weeks matches and predictions 1:41:30 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
Bacon is sick this week, out with a throat infection. But that's fine, as Jar of Jam has kindly stepped up to help the show this week. And it's a fun week of action, with some very interesting mailbag questions surrounding the Intel World Open, and the news of Johnnyboi's newest tournament. All this plus the RLCS and RLRS results for week 4. Timestamps: 0:00 - Intro --News-- 2:34 - Johnnyboi and Incivic announce the EU Invitational --Mailbag-- 8:11 - Intro 8:35 - Velixo: What are your way-too-early top picks for EU contries/teams qualifying for Katowice Olymipcs Qualifier? 20:13 - MattBlue: Who do you think would benefit the most from getting an experienced, winning coach (i.e. Gregan) on-board right now? --Tournament roundup-- 31:59 - Intro 32:23 - RLRS Results 33:46 - Servette Geneva lose everything 42:18 - Triple Trouble still struggling to find their footing 49:27 - Notorious Legion fluff their double header week 54:32 - Next weeks matches and predictions 1:00:05 - RLCS Results 1:01:29 - The Singularity problem 1:06:35 - Veloce taking wins, but showing the signs of the things we were concerned for 1:09:48 - FC Barcelona look like a team, Reciprocity don't 1:18:45 - AS Monaco and TSM rightfully at the bottom. What happened? 1:22:35 - Mousesports back in the choke zone 1:31:37 - Next weeks matches and predictions 1:43:07 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
An interesting week in the world of Rocket League, as the Intel World Open details are announced and the rulebook is leaked, teams are signed, and we get some unexpected results in the RLCS. Timestamps: 0:00 - Intro --News-- 4:28 - Intel World Open rulebook, dates and information leaked 20:31 - Someone is trying to sabotage Mousesports and Scrub Killa 26:25 - RLRS teams latest to be picked up by organisations --Mailbag-- 28:53 - Intro 29:11 - Freecant: What do you think of players that make it straight into the RLCS without playing in rlrs quals or rlrs first. Why are they so special and how do they get known? 33:50 - Freecant: If you could make a dream team of EU RLRS players, who would you have on it and why? --Tournament Roundup-- 36:38 - Discord Pick 'em challenge results 39:47 - RLRS results 41:17 - Notorious Legion with a top debut 44:45 - RCD remaining on top and undefeated against WDG 52:02 - Servette Geneva go 1-1 on their debut week 58:15 - 2 close results for Solary, but no wins on the board 1:01:21 - Next weeks matches and predictions 1:05:50 - RLCS results 1:06:52 - The Singularity issue 1:18:29 - The Risers Rivalry doesn't end the way of ASM 1:27:26 - Is it time to change the narrative on Veloce? 1:36:00 - Vitality picking up wins, but not living up to their expectations 1:44:43 - Next week's matches and predictions 1:49:44 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
2020 kicks off with a bang. All the rumours spilt out for you here, including several roster confirmations and news info in preparation for the next season of RLCS. We also take the first questions from our Discord fans on the Mailbag segment for this week, including questions about cancelling Reddit and RLRS qualification seeding. Timestamps: 0:00 - Intro --News-- 1:52 - RLAfterShock nominated for an r/rocketleagueesports subreddit award 6:14 - Oscillon, Blurry & Alex161 team up for RLRS qualifiers 10:04 - Scrub Killa departs from Renault Vitality 12:05 - TSM confirm Alpha and Jake leave the team 21:45 - al0t announces his departure from Mouz in the most creative way --Mailbag-- 25:44 - Intro 26:17 - Yens: Should Reddit just be canceled at this point? 34:14 - John_aka_Always: Various questions about seeding for RLRS Play-in's --The Rumour Mill-- 53:24 - Intro 54:29 - Discombobulators and their organisation 57:55 - FC Barcelona and Yukeo Updates 1:04:31 - Mousesports' newest member as per-sources 1:08:38 - Method's new confirmed 3rd as per-sources 1:16:34 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
Sharing Real Love Real Stories wins for the year. Giving my shoutout to: Podcasts guests, to my listeners, storytellers, the attendees who came to live events, Heard Museum for collaborating with RLRS and for my team for supporting me. Also sharing the Top 10 episodes for 2019 that have been listened to the most.
Hey friends! Perino is back this week alongside his friend and teammate Zenlos to recap a weekend of promotion and relegation. It appears the death of the Big Three does not extend all the way to the RLRS... Make sure to tune in for another great episode!
We're approaching the final weeks of the RLCS, meaning promotions are right around the corner. This week we discuss the results from the RLRS playoffs and how that has affected the Promotion tournament this weekend. Plus Jay and Bacon take Mailbag questions as usual and further add to the discussion of Franchising the RLCS. 0:00 - Intros 2:08 - Housekeeping and welcoming the new influx of viewers to the podcast --News-- 5:58 - Gold Rush return with an episode of Rush Hour --Mailbag-- 9:08 - Intros 9:41 - notblondmonkey: Now that they've become more commonplace, is it still too early to make a fair judgement about the impact that a coach has upon a team? 16:49 - John_aka_Alwayz: Which EU RLCS team to not make worlds has been the biggest disappointment 24:09 - velixo: Reciprocity and in the past Dignitas have proven it's possible to get consistent results in EU. What could other EU teams viably do to achieve similar consistency? --Feature discussion-- 33:16 - The Pro's, Con's, and alternatives to Franchising the RLCS --Tournament roundup-- 1:01:31 - RLRS Playoffs results 1:03:03 - AS Monaco and Discombobulators prove to be the best 1:17:58 - Singularity just miss the mark 1:24:27 - Method dagling on the edge --Tournament Preview-- 1:25:10 - RLCS Promotion Playoffs 1:36:52 - Outros RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
James gives you the lowdown on last weekend's RLRS action as we confirm 8 teams playing in RLCS S9
James gives you his and Josh's predictions for the RLRS Regionals
RLCS playoffs are over, and we're talking about the results as standard. All the results of the best teams that made the ultimate underdog runs, and the teams that had the ultimate bottling. Plus we preview the RLRS playoffs, and a few of the smaller bubble tournaments. All this plus the news from Madrid and the sad closure of Rewind on the show. Timestamps: 0:00 - Intro --News-- 1:51 - Silent Echo leaves Ghost, looking for new opportunities 7:30 - Madrid group stage format announced, and it's actually good 20:00 - Psyonix finally promoting the RLCS on the games front page 30:50 - Rewind gaming closes its doors --Mailbag-- 43:02 - Intros 43:27 - Aspect: With there being 10 teams in both RLCS and RLRS next season, what do you think the ideal promotion and relegation format should be? How many teams do you think should be promoted and relegated? Should any teams from RLCS be auto promoted without having to play in any promo tourney, or vice versa? 48:13 - How you can get involved with the Mailbag segment --Tournament previews-- 48:57 - Intros 49:58 - TCS Esports League finals 56:53 - BESL Finals 1:00:36 - RLRS Playoffs --Tournament Roundup-- 1:13:33 - RLCS Playoffs results 1:14:32 - Bottlesports in full effect 1:21:47 - Dignitas manage a performance 1:28:56 - FCB get reverse swept out of the season 1:37:27 - Vitality make LAN 1:42:07 - REcipricity take the EU championship 1:45:21 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
It's decision week as we look towards the regional playoffs. Our thoughts rest with TSM and coL this week as they are set to defend in the relegation tournament, but the RLRS still is to decide who challenges them. Plus Jamesbot's recent announcement and new signings leave more orgs in EU Rocket League than ever. Timestamps: 00:00 - Intro --News-- 02:48 - Remkoe hinting at roster changes 06:51 - Echo Zulu to explore other options 11:30 - Jamesbot leaves Twitch to be a full time commentator 18:12 - Singularity sign Flomp Resont --Mailbag-- 24:53 - Intro 25:47 - Cameron161: For next season, it would be good to have 16 teams qualify for RLCS worlds. How would you suggest determining those 4 teams qualifying? 35:11 - tyswoogles: If Veloce had made RLCS this season via promotiuon tournament and kept Nielskoek do you think they would have still done this well? 38:17 - John_aka_Always: What are your guys thoughts on RLCS League Play MVP voting? Do you interpret as actual most valuable player or straight uip best player? Or a balance of both value and raw performance. On a similar note, who would be your top 3 for MVP voting? --Tournament roundup-- 47:12 - RLRS Results 49:51 - An important win for Method 52:45 - Singularity make a great debut in their Rocket League campaign 56:39 - Underwater Squad, a major disappointment 1:01:45 - Another Rival Series Season for ARG and Baguette Squad 1:05:18 - Disacombobulators, dominant as ever 1:10:43 - RLCS Results 1:11:56 - TSM vs FCB. Our questions are answered 1:17:38 - Complexity with the shutout season 1:23:40 - The quiet but successful season from Dignitas 1:28:33 - Mouz lose both week 5 series, still manage top 4 1:34:25 - Reciprocity clinch first place 1:27:41 - Veloce make LAN 1:44:13 - Regional playoffs preview 1:49:33 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
The final week of RLCS is around the corner, and things are looking wide open after week 4. Jay and Bacon take you through the penultimate league play day of the Championship and take a look into the next generation with the RLRS results as well. Plus the Discord mailbag is in full swing, with more questions from the fans and the latest news from the EU scene. Timestamps: 00:00 - Intro --News-- 01:47 - Recripocity signs Yumi_Cheeseman as Manager and Coach 05:00 - Cheerio announces retirement --Mailbag-- 11:30 - Intro 13:49 - Yens: Would a RIVAL esports format with bo3/bo5 or even bo7 be a viable option for RLCS/RLRS? 23:52 - Tagmata: A suggestion I just thought about. What are your thoughts on breaks in Rocket League? It could work with like a 30 second wait time after a goal has been scored that each team would have one per game. How would you feel this would impact the competitive scene? 27:06 - Yens: Is Veloce's performance just a fluke or do you think it's nothing special for a promoted RLRS team to get such good results in RLCS? --Tournament Roundup-- 32:52 - RLRS Results 34:50 - Echo Zulu are out 41:00 - Underwater Squad continuing to Disappoint 45:57 - Flomp Resont soar ahead in first 50:07 - Baguette Squad edge out ARG in ranks, but not in head to head 55:03 - Method remain in the top 4, but lose severe ground 1:01:59 - Next week's matches 1:03:46 - RLCS Results 1:05:06 - Complexity down in relegations once again 1:09:50 - Reciprocity drop from first place 1:13:23 - Mouz take the lead 1:17:53 - TSM surprise against Veloce 1:25:00 - Dignitas in danger 1:31:12 - Next weeks matches 1:33:32 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
A week out leaves a lot of catching up to do. In this episode, Jay and Bacon spend time catching up on the news from the Rocket League scene as well as all the results from the last 2 weeks of RLCS and Rival Series. Plus the audience mailbag returns with some interesting questions from the discord. Timestamps: 00:00 - Intro --News-- 02:48 - Psyonix announce the Winter "Roadmap" 06:44 - AS Monaco pick up Fadeaway 08:42 - Copenhagen Flames pick up a new team 13:23 - Psyonix secure partnership deal wit CDW, implies a new ELEAGUE tournament 17:28 - Rocket League officially released in China 23:00 - Lottie Van-Prag announced as the RLRS mainstream host 29:40 - RCD Espanyol picks up Pepetyos Canyons 30:59 - LPL brings Yumi Cheeseman on for the OCE Championship finals --Mailbag-- 38:13 - velixo: Do you think we'll be seeing coaches on stage for Madrid? 44:44 - velixo: Any guesses or rumours PSG in Rocket League moving forward? 48:13 - tyswoogles: Is it surprising to you that ARG are struggling this season of rival series after a top 3 finish last season? 51:26 - dex: Veloce are having a season very reminiscent of S6 mousesports, having a monstrous week 1 going 2-0, then falling to the league's best team in week 2. Does this team have the calibre to avoid repeating S6 mouz's fate of barely scraping above relegation on game difference, or could they find themselves in a similar or worse fate? 54:32 - Tagmata: With the addition of the ASTRONAUTS Star Circuit, what are your guys' thoughts on this if you haven't already talked about it? --Tournament Roundup-- 1:03:44 - Tournament brief 1:05:59 - RLRS Results 1:07:53 - RLRS discussion 1:27:51 - RLCS Results 1:29:43 - RLCS Discussion 2:04:18 - Next weeks matches 2:08:31 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
It's guest time this week, as Bacon is ill from the LAN flu. Craftman takes his place as we discuss the latest drama surrounding Veloce, and the ticket sales for Madrid that caused a riot among the community. All this plus the first week of results from the RLCS and RLRS competitors. Timestamps: 00:00 - Intro 02:46 - News: Fadeaway looking to get signed? 08:58 - News: Complexity and Spacestation Gaming get in game esports items 11:45 - News: Veloce add Miztik as coach to the RLCS roster 14:54 - Drama: Nielskoek on getting kicked from Veloce and the ridiculous drama that followed 35:39 - Drama: RLCS Tickets go on sale - The Ticket issue 49:54 - Drama: RLCS Tickets go on sale - The Spanish issue 1:01:37 - Tournament roundup: RLRS Week 0 1:13:41 - Tournament roundup: RLCS Week 1 1:30:11 - Mailbag 1:41:00 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
RLRS's play-in's have concluded, and that can only mean a recap show. Today we take a look at the 128 team bracket of the RLRS Play-in's and discuss all the winners and losers of the newly promoted. Plus we're asked a question about the format of the RLRS qualification system and Psyonix announce the official replacement for in-game crates. Timestamps: 00:00 - Intro 02:24 - News: Psyonix announces their replacement plan for crates 13:04 - Mailbag 32:46 - Tournament Roundup: RLRS Play-in's 1:42:30 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
Ryan hosts this week along with a crew of RLRS hopefuls to discuss who they think will make the cut and why.
It's been a slow offseason, hasn't it? Well, it's time to kick things up a notch, with Dreamhack Montreal this weekend. Jay and Bacon break down all the teams, groups and storylines for the final Dreamhack event of the year. Plus new lineups announced for the RLRS qualifiers and the sad news that LoR is closing its doors. Timestamps: 00:00 - Intro 01:22 - News: RLRS Roster announcements 33:30 - News: League of Rockets closes its doors 39:30 - News: CRL adds Faceit as its tournament platform 44:52 - Feature: DH Montreal full preview 1:30:32 - Breaking: Renegades to pull out of Montreal 1:34:25 - Breaking: Frontline Signed to Receprocity 1:41:06 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
SHR # 2391 :: RLRx: Peptide Stack for Body Re-composition, Fat Loss and Fitness : Ronnie Milo - By combining specific peptides you an speed results if your goal is to get lean, muscular and fit. Here's the formula.
SHR # 2391 :: RLRx: Peptide Stack for Body Re-composition, Fat Loss and Fitness : Ronnie Milo - By combining specific peptides you an speed results if your goal is to get lean, muscular and fit. Here's the formula.
As we approach DreamHack Dallas, Jay and Bacon break down who's in and out of next season of RLRS. Meanwhile rumours are about (since confirmed) about the acquisition of senior Overwatch League staff joining Epic Games. Timestamps: 00:00 - Intro 01:14 - News: More leaks from Triple Trouble potentially joining Faze 12:51 - Report: Overwatch League commissioner, Nate Nanzer, announces that he's set to join Epic Games 26:00 - Tournament: TCS Esports League 44:45 - RLCS: Promotion Playoff's roundup 1:13:32 - Outro RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
RLCS is over, the LAN finalists have been found and we know who's fighting for the spots of next season. This week Jay and Bacon go through the motions and recap the regional finals as well as the last week of RLRS league play. All this plus the Faceit integration news that has Jay triggered, but not for what you might think. RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock Timestamps: 00:00 - Intro 02:25 - Faceit begins it's closed Beta for Rocket League 12:09 - Alpha awarded RLCS season MVP 15:05 - Tournament roundup: RLRS 30:13 - Tournament roundup: RLCS 55:58 - Outro
This week was a hell of a week for Rocket League...literally. We focus on the pure drama outpour of this week. From Fruity calling out Renault Vitality, to the banning of Demonator. Plus we look at the Dreamhack Pro Circuit Dallas qualifiers and the latest from the RLCS and RLRS in a massive tournament roundup of the week. RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
On today's Esports Minute, Mitch talks about elite women competitors in esports. Rate and subscribe! New episodes Monday through Friday. Follow Mitch on Twitter @Mitch_Reames (https://twitter.com/Mitch_Reames) Follow Esportz Network on Twitter (https://twitter.com/EsportzNetwork), Instagram (https://www.instagram.com/esportznetwork/), and Facebook (https://www.facebook.com/EsportzNetwork) @EsportzNetwork Or visit our website esportznetwork.com (https://www.esportznetwork.com/) for updates on what's to come!
Notice:All Esports Minutes have been moved to the Esports Minute (http://esportsminute.fireside.fm) podcast where new episodes may be found. On today's Esports Minute, Mitch talks about elite women competitors in esports. Rate and subscribe! New episodes Monday through Friday. Follow Mitch on Twitter @Mitch_Reames (https://twitter.com/Mitch_Reames) Follow Esportz Network on Twitter (https://twitter.com/EsportzNetwork), Instagram (https://www.instagram.com/esportznetwork/), and Facebook (https://www.facebook.com/EsportzNetwork) @EsportzNetwork Or visit our website esportznetwork.com (https://www.esportznetwork.com/) for updates on what's to come!
On this weeks edition of AfterShock, it's Bacon's week off as we take a trip into the wonderful world of the bubble scene. We're previewing the RLRS qualifiers, recapping our favourites, dark horses, and picking our top 4 teams to qualify to the RLRS this season. All this plus we look at the good and bad news of the week, and answer questions from our Discord mailbag RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
This week on AfterShock, the we're all in preperation mode for RLRS qualifiers. We talk about the Triple Trouble troubles, the quick signing and un-signing of Servette Geneva and we recap the Rival Esports Winter Open. RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
This week we discuss Unilad going bankrupt and how it might affect the Gfinity Elite Series, plus we look at the last week of the RLCS and RLRS. All that whilst we take a look at your questions in this weeks mailbag. RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
This week on After Shock, Jay is recovering from the CS Major, but Bacon is carrying the analysis. We discuss the RLRS server problems, goal revoke rulings, Red Reserve's rumoured pick up, plus all your RLCS and RLRS results for the week. RLAfterShock: Join our Discord: https://discord.gg/HyKUXAm Follow our Twitter: https://twitter.com/RLAfterShock
Boy do we have an episode for you this week. First off, we talk about our experience with the 3 new updates we got last week? What??? We also get to talk in detail about everything coming to Rocket Pass! Fan Rewards are now available for RLCS, RLRS and CRL and in Ninja's Super Happy Esports Fun Time, we talk about who made it into the RLRS for the third season!
Fantastic week, we get to talk about the Switch Rewards for RLCS and the backlash on reddit about servers. We also had issues on the weekend for RLCS and even RLRS. Tune in for more information about it all!
Have you watched all of RLCS to get your new rewards? Rocket League are going to be making presentations at GDC, we got the results of the RLRS Play-Ins. We also have the LFM Fantasy back again!
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 14/19
Eine Glomerulonephritis kann durch eine virale Infektion verschlechtert werden, sie kann aber auch erst durch diese entstehen. Die Erkennung der viralen Bestandteile erfolgt über Pathogenerkennungsrezeptoren, wie beispielweise Toll-like Rezeptoren und RIG-like Rezeptoren. Die Hypothese der vorliegenden experimentellen Arbeit war, dass die nierenspezifischen Podozyten Pathogenerkennungsrezeptoren besitzen, die pathogen-assoziierte molekulare Muster erkennen und daraus Zytokine und antivirale Typ-I Interferone produzieren. Hierbei könnten Podozyten zu der Entstehung bzw. Veschlechterung einer virusassoziierten Glomerulonephritis beitragen. Murine Podozyten exprimieren, mit Ausnahme des Toll-like Rezeptors 8, alle bis dato bekannten Toll-like Rezeptoren (TLR-1 bis -11) in verschiedener Ausprägung. Sie exprimieren außerdem die zytosolische Rezeptoren RIG-1, MDA-5, DAI sowie deren Adaptermolekül IPS-1. Die Aktivierung dieser Rezeptoren verursacht die Produktion von Zytokinen und Typ-I Interferonen. Um die intrazelluläre Aufnahme der Nukleinsäuren zu gewährleisten, wurden diese mit kationischen Lipiden komplexiert. Dieser Vorgang wurde durch Cytochalasin D, Chlorpromazin und Methyl-β-Cyclodextrin unterbrochen. Daraufhin ergeben sich die Phagozytose, die Clathrin-abhängige Endozytose und die Caveolae-vermittelte Endozytose als mögliche Transportmechanismen. Das Adaptorprotein MyD88 zeigte bei Podozyten keine Bedeutung für die Nukleinsäureaufnahme in die Zelle zu besitzen. Die Stimulation von Podozyten mit Typ-I Interferonen veranlasste die Produktion von großen Mengen an Interleukin-6 und führte zu einer starken Expression von Pathogenerkennungsrezeptoren sowie proinflammatorischen Zytokinen auf Transkriptionsebene. Eine autokrin-parakrine Aktivierung der Podozyten durch ausgeschüttete Typ-I Interferone konnten wir ausschließen. Weder die Durchlässigkeit für Albumin noch die Viabilität der Zellen wurde durch die Aktivierung von Pathogenerkennungsrezeptoren beeinflusst. Eine Funktionseinschränkung der Podozyten nach Stimulation der TLRs oder RLRs im Sinne eines direkten Einflusses auf die Permeabilität oder die Fußfortsatzzahl fand sich nicht, jedoch zeigten Podozyten eine vermehrte Zytokinproduktion, was zur glomerulären Entzündung bei viraler Glomerulonephritis beitragen könnte.
Topics:Patreon Update for MayCombo Story TimeBeginner's CornerGirlfriend sitting on RLRS caster's lapPromotion Playoffs Recap and DiscussionFollow us on Twitter: https://twitter.com/asapweeklySupport us on Patreon: https://www.patreon.com/ASAPWeeklyJoin our Discord: http://discord.gg/xRapH63Support this podcast at — https://redcircle.com/asapweekly-rocket-league-podcast/donationsWant to advertise on this podcast? Go to https://redcircle.com/brands and sign up.