Podcasts about MDA

An Epic E1000, N98FK, crashed near Steamboat Springs, Colorado during a night RNAV (GPS) approach. The lateral track was almost perfect, but the vertical profile was fatal: the airplane remained on an LNAV+V "advisory glide slope" and descended below the 9,100-foot MDA into terrain. Max explains what Garmin calls Advisory Vertical Guidance, why LNAV+V can look nearly identical to an LPV on the PFD, and why it does not provide obstacle protection below minimums. He shows the airplane crossed the FAF MABKY and stepdown fix WDCHK essentially on altitude—then continued descending instead of leveling at MDA. Max reviews the three requirements in 91.175(c) for descending below an MDA, explains why many autopilots will fly any coupled glidepath right through minimums unless you intervene, and decodes chart warnings like "Visual Segment – Obstacles" / "34:1 is not clear." He also shares his own simulator experience flying the RNAV (GPS) Z RWY 32 at KSBS and hitting the same mountain when the autopilot was coupled to the advisory glidepath. If you're getting value from this show, please support the show via PayPal, Venmo, Zelle or Patreon. Support the Show by buying a Lightspeed ANR Headsets Max has been using only Lightspeed headsets for nearly 25 years! I love their tradeup program that let's you trade in an older Lightspeed headset for a newer model. Start with one of the links below, and Lightspeed will pay a referral fee to support Aviation News Talk. Lightspeed Delta Zulu Headset $1299NEW – Lightspeed Zulu 4 Headset $1099 Lightspeed Zulu 3 Headset $949Lightspeed Sierra Headset $749 My Review on the Lightspeed Delta Zulu Send us your feedback or comments via email If you have a question you'd like answered on the show, let listeners hear you ask the question, by recording your listener question using your phone. Mentioned on the ShowBuy Max Trescott's G3000 Book Call 800-247-6553 Video of the Week: Free Index to the first 282 episodes of Aviation New Talk So You Want To Learn to Fly or Buy a Cirrus seminars Online Version of the Seminar Coming Soon – Register for Notification Check out our recommended ADS-B receivers, and order one for yourself. Yes, we'll make a couple of dollars if you do. Get the Free Aviation News Talk app for iOS or Android. Check out Max's Online Courses: G1000 VFR, G1000 IFR, and Flying WAAS & GPS Approaches. Find them all at: https://www.pilotlearning.com/ Social Media Like Aviation News Talk podcast on Facebook Follow Max on Instagram Follow Max on Twitter Listen to all Aviation News Talk podcasts on YouTube or YouTube Premium "Go Around" song used by permission of Ken Dravis; you can buy his music at kendravis.com If you purchase a product through a link on our site, we may receive compensation.

Lundi matin, des enfants ont frôlé le pire.Et Annaelle Sidoun, paramédic du MDA, était sur les lieux.

À l'occasion de notre partenariat avec LEGEND, nous avons le plaisir d'offrir à tous les spectateurs une remise exceptionnelle jusqu'à -10 % sur l'ensemble de nos sites.MDA : https://www.mda-electromenager.com/fr/Pulsat : https://www.pulsat.fr/fr/Phox : https://www.phox.fr/Gpdis : hhttps://www.gpdispro.com/Villatech : https://www.villatech.fr/fr➡️ Il vous suffit d'utiliser le code LEGEND10 lors de la commande.⌛️ Offre valable pendant 1 mois.Collaboration commercialeMerci à Michel Vieira d'être venu sur LegendMichel Vieira a débuté sa carrière comme réparateur à domicile avant de devenir aujourd'hui le dirigeant de MDA Company, un groupe de marques spécialisé dans l'électroménager à prix discount. Pour Legend, il a accepté de revenir sur son parcours, sur l'audace qui lui a permis de saisir des opportunités, et d'aborder des sujets clés comme l'obsolescence programmée, l'indice de réparabilité ou encore les objets connectés.Merci également à Gil Bartholeyns, auteur de « L'étrange et folle aventure du grille-pain, de la machine à coudre et des gens qui s'en servent » (disponible ici : https://amzn.to/3Leq9Mo), qui a accepté de venir sur Legend pour nous parler et nous montrer des anciens objets d'électroménager.Pour prendre vos billets pour le LEGEND TOUR c'est par ici ➡️ https://www.legend-tour.fr/Retrouvez la boutique LEGEND et nos offres pendant les soldes ➡️ https://shop.legend-group.fr/Pour retrouvez toutes les informations concernant nos invité c'est par ici ⬇️Michel Vieira :Son compte Instagram ➡️ https://www.instagram.com/michel.vieira_mda/Son compte Facebook ➡️ https://www.facebook.com/MichelVieiraOfficiel/aboutSon compte Linkedin ➡️ https://www.linkedin.com/in/michel-vieira-7ba55a175/Quentin VieiraSon compte Linkedin ➡️ https://www.linkedin.com/in/quentin-vieira/Vous voulez rejoindre un groupe dynamique ➡️ recrutement@mda-company.comMDA Devenir Franchisé MDA : https://www.mda-franchise.com/Site MDA : https://www.mda-electromenager.com/fr/MDA CUISINE MDA Cuisine : https://www.mda-cuisine.com/GPDISVous êtes professionnels ouvrez un compte chez Gpdis : hhttps://www.gpdispro.com/Vous voulez rejoindre un groupe dynamique : recrutement@mda-company.comRetrouvez l'interview complète sur YouTube ➡️ https://youtu.be/9BCNbDQ5H5UPour toutes demandes de partenariats : legend@influxcrew.comRetrouvez-nous sur tous les réseaux LEGEND !Facebook : https://www.facebook.com/legendmediafrInstagram : https://www.instagram.com/legendmedia/TikTok : https://www.tiktok.com/@legendTwitter : https://twitter.com/legendmediafrSnapchat : https://t.snapchat.com/CgEvsbWV Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this Mol Bio Minutes mini-episode, Laurynas Alijošius shares how Rolling Circle Amplification (RCA) provides a reliable, high-yield approach for amplifying circular DNA prior to next-generation sequencing (NGS). This isothermal method avoids the need for thermal cycling and even bypasses the need for specific primers—making it ideal for challenging viral genomes, rare targets, or field samples.Powered by the strand-displacing phi29 DNA polymerase, RCA amplifies DNA with impressive sensitivity and minimal GC bias. Laurynas breaks down the steps of multiple displacement amplification (MDA), explains why exonuclease-resistant primers are important, and explores how engineered polymerases like EquiPhi29™ DNA Polymerase dramatically improve yield and reduce reaction times. RCA products can be cleaned up and debranched to support a range of downstream workflows, including nanopore sequencing and transcriptomics.From single-cell genomics to phage-based applications and in vitro expression systems, RCA is more than just a pre-NGS step; it's a versatile tool with broad utility. Whether you're stabilizing viral RNA or tackling ultra-low-input samples, RCA and whole genome amplification offer new flexibility for today's demanding sequencing workflows. Subscribe to get future episodes as they drop and if you like what you're hearing we hope you'll share a review or recommend the series to a colleague.  Visit the Invitrogen School of Molecular Biology to access helpful molecular biology resources and educational content, and please share this resource with anyone you know working in molecular biology. For Research Use Only. Not for use in diagnostic procedures.

En este cierre de año, Wall Street busca impulso mientras los mercados se preparan para una semana corta por las festividades. Aquí están los temas clave del día:

Missouri Director of Agriculture Chris Chinn joins Jared for a deep dive into the realities of modern farming, livestock operations, rural policy, and how government programs actually impact producers on the ground. Whether you're a farmer, livestock producer, trucker, ag student, grain hauler, or rural leader, this episode gives you a front-row seat to the conversations shaping agriculture today. Chris shares her personal story of growing up in Missouri ag, running a diversified family farm, and balancing life between Jefferson City and the home operation. She breaks down federal aid programs, drought relief, weights & measures, livestock transportation rules, and how technology has transformed production agriculture in the last 20 years. If you want to understand where Missouri agriculture is right now — and where it's headed — this episode is a must-watch.

Drs. Beggs and Parsons discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at the MDA 2025 conference in Dallas, Texas, in March 2025, and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established in contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The ASPIRO clinical trial is on clinical hold since September 2021. In this part, Dr. Beggs will provide an introduction to gene-directed therapies.Alan Beggs, PhDI'm going to talk now about challenges, a little bit of background in the history and the development of AAV-mediated gene therapies, in particular for neuromuscular disorders. There are a lot of aspects about neuromuscular disease that make it a good group of conditions to target by gene replacement therapies. These are traditionally single gene disorders with known identified oftentimes protein deficiencies, so null mutations leading to lack of a protein.The primary tissue, the therapeutic target is a skeletal muscle, and so we can target that with the appropriate viral vectors. There's a major unmet medical need and substantial clinical burden for these conditions. As rare diseases, they place a very substantial burden on both health systems and patients, both economically and in terms of personal difficulties.I like to think about gene therapy, which is generically used for one category of this, to really think about gene-directed therapy. So this would be any therapy directed at the nucleic acids that are either encoding our DNA or are encoding the messenger RNA transcripts. So one approach to a gene-directed therapy can be directed at the RNA level. I think you're all familiar with the Exon-skipping approaches that target mRNA splicing.There are other methods for either knocking down toxic gain of function messenger RNAs, and there are methods now being developed to edit messenger RNAs. So this represents one class of gene therapy. You can also approach gene therapy at level of DNA by editing or changing the DNA in situ. So various CRISPR-Cas9-based approaches. There's now prime editing and other approaches for genetic engineering that target specific locations, often using bacteria endonucleasis that target with oligenucleotides that target specific sites.And then finally, there's gene replacement therapy, which is what we're going to spend most of our time on today, which really aims to not take away what's there and replace it, but to replace the missing protein product by providing a copy of the healthy or the complete wild type gene. Often, it can either be integrated into the chromosomes or remain extrachromosomal.So whether or not that happens really depends on the type of vector or approach you use. You can see here a number of different approaches for transferring in a therapeutic gene. The two most commonly used in clinical trials are lentivirus and AAV, and they have different strengths and weaknesses. Lentiviruses are used frequently for hematologic diseases.Lentivirus is a member of the retrovirus family and has the characteristic that it actually integrates into the DNA. So lentiviral treatments tend to be long-acting. However, they also suffer from the risk that by integrating into the DNA, you might have site-directed mutagenesis. And there have been known instances of cancers that arose through integration at the wrong site.In the next part, Dr. Beggs will cover the history and challenges in the development of AAV-mediated gene therapies.

Alan Beggs, PhDDirector of the Manton Center for Orphan Disease ResearchSir Edwin and Lady Manton Professor of Pediatrics, Boston Children's HospitalHarvard Medical School, Boston, MA, USA Julie A. Parsons, MDHaberfield Endowed Chair in Pediatric Neuromuscular DisordersProfessor of Clinical Pediatrics and NeurologyUniversity of Colorado School of Medicine, Children's Hospital ColoradoAurora, CO, USADoctors Beggs and Parsons discuss the current status of gene therapies in rare neuromuscular disorders in this eight part podcast series. This is derived from the symposium that was presented at the MDA 2025 conference in Dallas, Texas, in March 2025 and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established. In contents of this podcast, shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The ASPIRO clinical trial is on clinical hold since September 2021.In this part, Doctor Beggs will provide an explanation of AAV-mediated gene therapies.Alan Beggs, PhDAAV vectors, which I'm going to be talking about more today, or Adeno associated viral vectors are small viruses. Their DNA gets delivered into the cell and remains extrachromosomal. There are very rare occasional integrations, but the risk of oncogenesis as a result is significantly lower as a consequence of remaining extrachromosomal, though, we do have to think about what happens as the cells divide and potentially the durability of treatment is more limited.There have been a lot of movement and development over the years, starting back in the 1980s when the first AAV genomes were isolated and sequenced. This led to a development of methods to produce recombinant AAVs that would lack the genes necessary for viral replication, but contain a therapeutic gene you wish to deliver. Through this, the structure of AAVs have been developed. There have been isolation of a number of naturally occurring variants. You've heard of AAV8, AAV9, also RH 74, derived from a rhesus monkey for the RH. These have all been used in clinical trials. Then at the end I'll talk a little bit about directed evolution methods to actually engineer capsids with particular properties that are beneficial.Throughout this we've identified some of the issues that arise in this. It was initially thought that AAV vectors were non-immunogenic, but in fact there are immune responses not just to the viral payload to the therapeutic protein, but also to the viral vectors, and you're going to hear about that from Doctor Parsons. Over time, as we've come to understand these challenges, we've also been developing approaches to mitigate them. In terms of clinical trials and treatments, the very first studies were done back in the 1970s.By the early 2000, the very first clinical therapeutic was approved in China. It was actually an oncolytic virus carrying a p53 gene to treat head and neck cancers. By now there are over 40 approved treatments for various types of AAV delivered gene therapies. Of course, the ones we know a lot about are Zolgensma, which was approved in 2019, and Elevidys, which was approved last year. A number of challenges and then also a number of approaches to overcome those challenges. First of all, the preclinical data are not always sufficient to predict the response of a human patient.For example, in X-linked myotubular myopathy we had mouse and dog models that exhibited a myopathy but nothing else, and yet when we treated human patients, we discovered that patients with X-linked myotubular myopathy actually had a previously only poorly recognized hepatopathology that led to potential liver consequences following gene therapy. The animal models don't always predict the clinical outcome in humans.Also, we have small disease populations. These are rare diseases. It's important to understand the natural history of these diseases, understand the heterogeneity among the clinical population. It's very important to engage with families and with patients and communities, understand who might be at increased risk to treatment with one of these. This feeds into safety considerations. We need to think also about some of the immune responses. I think we're starting to learn, for example, with the gene therapies for Duchenne, and we know this from SMA that some patients get into trouble and others don't. We need to understand why that may be, and we don't know about the long term effects. This has been very recent.

Julie A. Parsons, MDHaberfield Endowed Chair in Pediatric Neuromuscular DisordersProfessor of Clinical Pediatrics and NeurologyUniversity of Colorado School of Medicine, Children's Hospital ColoradoAurora, CO, USANow, with our collective experience, we can at least put together the information that we have in terms of what can we expect and what's the timeline that we expect in terms of our patients having reactions. I will tell you, and I've said this multiple times, when I deliver a gene transfer therapy, I hold my breath for 2 months. Now, maybe it's going to have to be extended to a year, but it's typically at least for 2-3 months. It's like, okay, what's going to happen? You sit on the edge of your seat on pins and needles, going, "Is this kid going to be okay or not?" I think that's the appropriate response to have in terms of the light of things that have happened over time. We have to be really careful.We have a little bit of a framework now to say, when do we need to be really excited? We know that our patients, most all of them, are going to develop a transaminitis, and that ends up happening early on, but we get a couple of peaks. We get really excited that the 4-8 week time point with transaminitis looking for liver failure.The cholestatic liver disease that happened in the patients with X-linked MTM happened a little bit later, so Week 2, all the way out to six months afterwards. The acute cardiomyopathy a little bit earlier, so we're looking a little bit earlier for that effect. TMA, usually the end of the first week to about 2 weeks is when we would expect that to come in. Then the transgene-related myositis and immune-mediated myocarditis, weeks, maybe 2 to a couple of months.How do we adapt our gene transfer programs to the clinical trial experience? I think that there are a couple of points that are important. One is that the outline that I showed you, there are some disease-agnostic issues that come up with transaminitis, with TMA. I think there are some final common pathways related to the immune responses that we see with these patients. Then there are going to be some disease-specific disorders that are going to come up with each of these therapies and agents.We need to have good communication, honestly, in real-time. I still don't know that we have a good mechanism for that as a community, but to share these adverse events that come up so that we can all learn as a collective about what to expect, what to anticipate, and how to best take care of our patients. We know now how we need to monitor patients closely from a laboratory standpoint, from a clinical exam standpoint, and we really need to work on how are we going to mitigate some of these risk issues that we have with these patients.I think the collaborative aspect, particularly at meetings like this, is important. Last year, for the people that were at MDA, you remember that we really spent a lot of time looking at gene transfer delivery. Many of us got together as providers and actually met together to say, "Is there something that we can think about in terms of best practice or consensus in terms of how we would want to manage patients or how we'd want to share information?"Now, actually, on the MDA website, we really do have some guidelines, and there will be a publication coming out shortly that we'll have this available to everybody again. It's not necessarily the right answer, but it's at least from a collective experience, what's the best way that we can go forward? Some of the suggestions were that the adverse events right now, we can put them into some a predictable timeline, but we don't really know all the risks at the time of dosing.We know that gene transfer therapy can be safe for the right patient at the right time for the right disorder. That's really what we want to do. There's a Neurotherapeutic window between efficacy and toxicity. How are we adjusting that? What are we working on to make sure that we're getting that right? The preclinical data is helpful, but it's never the full story. Any time we go from a homogeneous population that we see in a clinical trial to a heterogeneous population, as we throw this out to the world, we're going to have new issues that arise, and we need to be aware and ready for those.We want to be able to predict what happens, but we can't always do that. Then follow-up is so important. The post-marketing study, sharing adverse events, sharing experiences, I think, is really important as well. Clinicians really should be familiar with this entire field before ever delivering gene transfer therapy. I don't think that every site should be delivering gene transfer. I think that from an institutional standpoint, you need to be ready. You need to have a team who knows what they're doing and knows how to handle the issues and the problems, or you need to have lifelines set up in advance if you're going to deliver these treatments.

Prepare seu navio pirata ou sua nuvem voadora, pois desta vez no ⁠⁠⁠⁠⁠⁠⁠⁠Mundo dos Animes⁠⁠⁠⁠⁠⁠⁠⁠, Raul⁠⁠⁠⁠⁠⁠⁠⁠, Ansem e Vulpixs ⁠⁠⁠⁠ comentarão detalhes da produção do especial MDA no Isekai: O Segundo Despertar.SEJA NOSSO APOIADOR E AJUDE O PODCAST A CONTINUAR EXISTINDO: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Catarse⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Mande um e-mail para nossa Caixa Postal comentando sobre o episódio:podcast@mundodosanimes.comTempo de duração: 59 minutosArte da Vitrine: Lucas MáximoPauta: Raul LimaEdição: Lucas Máximo⁠⁠⁠⁠⁠⁠⁠⁠VISITE O SITE DO MUNDO DOS ANIMES⁠⁠⁠⁠⁠⁠⁠⁠Redes Sociais:⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Discord⁠

Most teams skip design documentation and pay for it later, in miscommunication, scope creep, and wasted development time. This session reveals how proper design docs streamline your entire pipeline. Learn the MDA framework for evaluating features, documentation techniques that actually help your team build faster, and how to communicate design decisions that reduce rework. Whether you're solo or managing a studio, discover why thinking like an architect (not just a builder) prevents bottlenecks and keeps production on track. Includes real templates and workflows used in professional studios.

En la entrevista del programa La Miel en tu radio conversamos con el Ing. Agr. Ariel Guardia López - Dir. Apícola de Ministerio de Desarrollo Agrario MDA 6/12/2025 con quien conversamos sobre los resultados anuales del programa mi primera colmena del MDA.

IM (27/10/1969 – 3/12/2015) –  Scott Weiland is Dood maar niet vergeten. De Amerikaanse rockzanger is vandaag in 2015 op 48-jarige leeftijd overleden in zijn slaap. Overigens wel aan een overdosis cocaïne, MDA en alcohol. Het is…Continue Reading "Tiende sterfdag Scott Weiland (STP)"

Harmony and Russell talk with researcher and author Matt Zemon about psychedelics as catalysts for change, not cures. They explore what current studies suggest about anxiety, PTSD, repetitive thinking, and addiction, then ground the conversation in practical guidance: source, set, and setting, medical intake, and the role of preparation and integration. The trio also contrasts medical and ceremonial lanes, the spiritual significance of entheogens, and how community transforms the healing arc—especially for veterans and for people navigating midlife transitions. What You'll Learn Catalyst vs. cure: why altered states create openness for change, and why integration is the practice that makes it stick Repetitive thinking patterns: how psychedelics may interrupt ruts that manifest as anxiety, depression, OCD, compulsions, or workaholism Source, set, and setting: a clear safety-first framework echoed by research institutions Preparation: clarifying intentions, tending physical space, and naming post-ceremony supports Integration: bringing insights into dishes, deadlines, and relationships, plus finding community that fits your path Medicine personalities: distinctions between ketamine, MDMA and MDA, psilocybin, LSD, ayahuasca, iboga/ibogaine, wachuma and peyote Risk basics: why independent medical consults matter, medications that conflict, and when supervised care is non-negotiable Spiritual context: clinical findings alongside living spiritual traditions, and why collaboration between science and spirit is needed now The information provided in this episode is for educational and informational purposes only. It does not constitute medical, psychological, or legal advice, and should not be relied upon as such. Psychedelic substances remain illegal in many jurisdictions, and their use carries physical, psychological, and legal risks.  If you are struggling with your mental health or substance use, please seek support from a licensed professional or contact your local mental health helpline. About Our Guest — Matt Zemon Matt holds a Master's in Psychology and Neuroscience from King's College London and is completing a Doctorate of Ministry at the Pacific School of Religion. He's the author of Psychedelics for Everyone, Beyond the Trip, and The Veteran's Guide to Psychedelics created with the Heroic Hearts Project. Matt works at the intersection of spirituality and mental health, helping communities and providers reduce risk and support meaningful, safe experiences. Resources Mentioned (pulled from the convo) Guest site: mattzemon.com Books: Psychedelics for Everyone, Beyond the Trip, The Veteran's Guide to Psychedelics Organizations and references mentioned: King's College London Pacific School of Religion Heroic Hearts Project Johns Hopkins, NYU, UCSF psychedelic research programs spiritpharmacist.com (Dr. Ben Malcolm), Dr. Emily Kopa On safety frameworks: source, set, and setting On community and faith-based contexts: Christian, Jewish, and Islamic psychedelic groups were referenced generally Call to Action Join Harmony's 21-Day Money Magic and Manifestation Challenge starting November 3 with a bonus live activation on Sunday, November 2. Check the show notes link to register, get the Manifestation Activation right away, and meet the community. Subscribe, rate, and review the show. Turn on automatic downloads. Say hello on Instagram: @findingharmonypodcast and @harmonyslaterofficial. Upcoming events: https://harmonyslater.com/events 21 Day Money Magic Manifestation Challenge: https://community-harmonyslater.com/landing/plans/1542444Use PROMO CODE for additional $20 Savings: MANIFESTATIONMAGIC  FREE Manifestation Activation: https://harmonyslater.kit.com/manifestation-activation FIND Harmony: https://harmonyslater.com/ JOIN the Finding Harmony Community: https://community-harmonyslater.com/ Harmony on IG: https://www.instagram.com/harmonyslaterofficial/ Finding Harmony Podcast on IG: https://www.instagram.com/findingharmonypodcast/ FREE 2 min breathwork practice: https://harmonyslater.com/morning-breathwork-optin Find your Spiritual Entrepreneur Archetype! Take the Quiz! https://harmonyslater.com/spiritual-entrepreneur-archetype-quiz BOOK Your Spinal Energetics Session: https://harmonyslater.as.me/

We're on-site at the Abilities Expo in Schaumburg meeting Samantha, a freshly graduated 18-year-old heading to UIC who speaks with clarity about independence, dignity, and the everyday design of an accessible life. This isn't inspiration theater. It's practical courage: how to choose a major, compare campuses, and advocate for accommodations while keeping joy and curiosity in the driver's seat.Samantha walks us through life with a rare distal SMA, explaining her mobility in simple, honest terms and the mindset shifts that help her move from can't to how. She opens up about navigating high school among mostly able-bodied peers, finding friends who lead with respect, and attending MDA camp where perspective deepened into gratitude. We talk candidly about ramps and elevators, yes, but also about the less visible layers of access: seating layouts, syllabus flexibility, communication with professors, and the social cues that make classrooms feel human. Her plan to start at UIC and possibly transfer to UIUC illuminates the real calculus many students with disabilities face—community versus proximity, services versus cost, growth versus comfort.Family runs through this conversation like steel cable. A sister who turns visibility into pride, a mom who scouts tools and options, and a veteran dad whose philosophy is simple and strong: you can do hard things, differently.Samantha's message is one to carry: you're not alone, it might be harder, and you are more than what meets the eye.Press play for a grounded, hopeful take on college accessibility, disability advocacy, and resilience you can use. If this resonated, follow the show, leave a review, and share it with someone who needs proof that independence has many paths—and all of them start with your voice.

O Fala Carlão marcou presença no Rio+Agro, direto do Rio de Janeiro/RJ, em uma cobertura especial para o Canal do Boi que reuniu grandes nomes e destacou o protagonismo do agro fluminense.Entre os destaques, Fabiana Villa Alves, adida agrícola do Brasil para a Etiópia e União Africana; Marcello Brito, secretário-geral do Consórcio Amazônia Legal; e Victor Tinoco, superintendente do MDA no Rio de Janeiro, falaram sobre o papel estratégico do estado e o impacto do agro em diferentes regiões e setores.Foi um encontro que reforçou a importância do Rio de Janeiro como ponto de convergência entre sustentabilidade, inovação e desenvolvimento, mostrando que o agro é parte essencial do presente e do futuro do Brasil.

Description: Listen as NPF Medical Board Members, dermatologist Dr. Robert Kalb and rheumatologist Dr. Sergio Schwartzman discuss the connections between psoriasis and psoriatic arthritis, from cytokines to triggers, current and future treatments.   Join moderator Alan Simmons as he gains insights on what connects psoriasis and psoriatic arthritis with leading experts in psoriatic disease and NPF Medical Board members, dermatologist Dr. Robert Kalb with Buffalo Medical Group Dermatology, and rheumatologist Dr. Sergio Schwartzman from Schwartzman Rheumatology, as they discuss the known drivers of psoriasis and psoriatic arthritis, common triggers, benefits of targeted treatments, remission of disease, and upcoming treatment trends. The intent of this episode is to identify potential connections between psoriasis and psoriatic arthritis, and how targeted treatments have changed the outlook for management of psoriatic disease. This episode is sponsored by Novartis. Timestamps: (0:41) Intro to Psoriasis Uncovered and guest welcome dermatologist Dr. Robert Kalb and rheumatologist Dr. Sergio Schwartzman who are both involved in clinical care and research of psoriasis and psoriatic arthritis.  (1:15) Current known pro-inflammatory cytokines and cells found in psoriasis and psoriatic arthritis.   (5:33) Types of psoriasis that may lead to a higher risk of developing psoriatic arthritis. (9:33) Common triggers for psoriasis and psoriatic arthritis that could cause flares of the disease. (12:59) Key factors that are considered when choosing a treatment plan for any individual with psoriatic arthritis and psoriasis. (18:04) What treatment remission means for psoriasis. (19:36) Use of minimal disease activity (MDA) in psoriatic arthritis and what it means. (22:14) How a better understanding of the disease has led to more effective treatment choices and what choices are used by Dr. Kalb and Dr. Schwartzman for the management of psoriasis and psoriatic arthritis. (28:39) New developments in treatment and research in psoriatic arthritis and psoriasis. (36:01) Given treatment advancements it's a wonderful time to treat psoriatic disease. 3 Key Takeaways: ·       Cytokines are chemicals in the body that moderate various processes. In psoriasis and psoriatic arthritis,  an unknown trigger stimulates some cells to overproduce pro-inflammatory cytokines such as TNF-alpha, IL-17 or IL-23 leading to the development of skin and joint disease.  ·       Treating psoriasis and psoriatic arthritis helps move the body towards normalizing the over reactive immune system especially with more targeted treatments that safely and effectively block specific cytokines without affecting other organ systems.  ·       Given advancements in targeted treatments the goal is to reach and maintain remission of psoriatic disease. Guest Bios:   Leading dermatologist Robert Kalb, M.D. is the Chair of the Buffalo Medical Group Dermatology Department and the Director of the Buffalo Medical Group Phototherapy Center, one of the leading centers for psoriasis care in Western New York. He is also a Clinical Professor of Dermatology at the State University of New York at Buffalo School of Medicine and Biomedical Sciences (SUNY Buffalo), as well as an Adjunct Professor of Dermatology at the Perelman School of Medicine at the University of Pennsylvania where he plays a significant role in medical education, mentoring both medical students and dermatology residents. Dr. Kalb has extensive experience managing psoriasis, atopic dermatitis, and other inflammatory skin diseases. He has authored 70+ publications and is actively involved in clinical research, particularly focused on new treatment options for psoriasis. He is a member of the NPF Medical Board, American Academy of Dermatology, and is a member of the International Psoriasis Council.  Sergio Schwartzman, MD, is a world-renowned rheumatologist based in New York City who brings almost 40 years of experience and personalized clinical care for those who have psoriatic disease. Along with being in private practice at Schwartzman Rheumatology, Dr. Schwartzman is a Clinical Associate Professor of Medicine at Weill Cornell Medical College of Cornell University, the New York-Presbyterian Hospital, and the Hospital for Special Surgery in New York City where he has played a role in educating medical students, residents, fellows, and peers in rheumatology. Additionally, Dr. Schwartzman is the emeritus Franchellie M. Cadwell Clinical Associate Professor at the Hospital for Special Surgery. Dr. Schwartzman's current research interests include psoriatic arthritis, the spondyloarthritis group of diseases, ankylosing spondylitis, rheumatoid arthritis, as well as defining and treating autoimmune diseases of the eye. He has authored, co-authored, and edited over 150 papers, abstracts, books and book chapters on topics including psoriatic arthritis, ankylosing spondylitis, axial spondylarthritis, rheumatoid arthritis, lupus, autoimmune eye disorders, and other rheumatological and autoimmune conditions. He is a member of the NPF Medical Board. He is also a member of the American College of Rheumatology, the Association for Research in Vision and Ophthalmology, the Spondyloarthritis Research and Treatment Network (SPARTAN), the American Uveitis Society, and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Resources: Ø  “Redefining Remission. A new definition for patients, providers, and payers.” Advance Online, National Psoriasis Foundation. S. Schlosser. July 14, 2025.   Ø  Treatment and Management of Psoriasis     Ø  Treatment and Management of Psoriatic Arthritis  

Landing your first job as a CRNA can feel overwhelming but knowing what to expect and how to approach the job market can ease a lot of the uncertainty. Today, Kevin and Olivia sit down with Jay Cobden, a 2023 graduate of Rhode Island College and trauma CRNA at Carolinas Medical Center in Charlotte, North Carolina, to hear about what he learned from navigating the process. After attending the AANA Annual Congress, Jay realized he had many of the same questions as other SRNAs about what to do next after school, and wanted to share that experience with others in this position.   Here's some of what we discuss in this episode:

We talk about the Community Development departments and several items from the City Council meeting, including the creation of a new Commercial Flex zone, an amendment to a commercial area, and possible ordinance changes to protect newly constructed roads from being dug up for underground work. Have a question? Leave a comment or email us at communications@herriman.gov and we'll address it in a future edition. 0:00 Start 0:34 Intro 1:37 Community Development departments 4:40 New Commercial Flex zone 10:25 "Crescent" MDA amendment 14:29 Contaminated soils 18:09 Road cutting ordinance 22:40 Wrap-up

Today, we sit down with Robert Patrick and Oliver Shokouh to share some info on the upcoming Love Ride #34! Since 1984, Love Ride has brought together riders, celebrities, and communities to support meaningful causes. From Glendale to Castaic Lake, every chapter in our history is a story of purpose, unity, and impact.Website - https://loveride.org/Instagram - https://www.instagram.com/loverideharley/Robert's Instagram - https://www.instagram.com/ripfighter/Robert's YouTube Channel - https://www.youtube.com/@UCXJINH_uItPwnM-enkNgnWw The Love Ride FoundationAfter a pause for a few years the Love Ride returns in 2025 with renewed energy and focus for the 34th installment. The good times will roll from the historic ride starting location of Harley-Davidson of Glendale to Castaic Lake, CA. Love Ride 34 powered by Harley-Davidson brings back the legacy, the excitement, and the purpose—riding to support our troops, first responders and kids!The Love Ride Foundation is a 501(c)(3) nonprofit founded by Oliver Shokouh. Its purpose is to raise funds to support organizations improving lives through health, education, and other forms of support. Over the years, the Foundation has proudly partnered with groups including Autism Speaks, Big Brothers Big Sisters, Children's Hospital Los Angeles, MDA, Wounded Warrior Project, and more.OUR WEBSITE: https://2lanelife.com/ USE CODE: "YOUTUBE" FOR 10% OFF OF PARTS & ACCESSORIES2LANELIFE INSTAGRAM: https://www.instagram.com/2lanelife/GAYLIN'S INSTAGRAM - https://www.instagram.com/xerox57/LANCE'S INSTAGRAM - https://www.instagram.com/biglancec/JOSH'S INSTAGRAM - https://www.instagram.com/imridingplaces/Want to SAVE on EagleRider Rentals? - CLICK HEREABOUT 2LANELIFEWe travel the country on our Harley-Davidson motorcycles, exploring some of the best roads the country has to offer. Our goal is to share all of the neat history and attractions across the back roads, a.k.a. the 2Lanes of America using a cinematic approach unique to our experiences. Along this journey, we meet tons of amazing people, and learn something new every time. We are here to inspire travel!Friends:Thrashin' SupplyLegend SuspensionsCustom Dynamics Motorcycle LightingEagleRider Motorcycle Rentals & Tours Feuling PartsKlock WerksCobra USAMaxima Racing OilsBell HelmetsSaddlem...

Caleb Henry, Director of Research at Quilty Space, joins me to talk about EchoStar's spectrum sales and constellation cancellation, SpaceX's spectrum purchase, and the financials of Starlink.This episode of Main Engine Cut Off is brought to you by 34 executive producers—Bob, Heiko, Creative Taxi, Josh from Impulse, Russell, Donald, Will and Lars from Agile, Matt, Steve, Lee, Joel, Tim Dodd (the Everyday Astronaut!), Frank, Natasha Tsakos (pronounced Tszakos), The Astrogators at SEE, Better Every Day Studios, Ryan, Kris, Pat, Joakim (Jo-Kim), Stealth Julian, Warren, Theo and Violet, Jan, Joonas, Fred, David, and four anonymous—and hundreds of supporters.TopicsQuilty Space (@QuiltySpace) / XStarlink Financial & Strategic Analysis 2025 1H | Quilty SpaceSign Up Form | Quilty SpaceEchoStar sells spectrum to SpaceX, cancels MDA satellite contract - SpaceNewsEchoStar's $23 billion spectrum sale clears path for direct-to-device constellation - SpaceNewsEchoStar orders initial MDA satellites for $5 billion LEO constellation - SpaceNewsThe ShowLike the show? Support the show on Patreon or Substack!Email your thoughts, comments, and questions to anthony@mainenginecutoff.comFollow @WeHaveMECOFollow @meco@spacey.space on MastodonListen to MECO HeadlinesListen to Off-NominalJoin the Off-Nominal DiscordSubscribe on Apple Podcasts, Overcast, Pocket Casts, Spotify, Google Play, Stitcher, TuneIn or elsewhereSubscribe to the Main Engine Cut Off NewsletterArtwork photo by CMSEOWork with me and my design and development agency: Pine Works

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Overviewing Consensus Guidelines to Standardize Gene Therapy Care in Duchenne," Barry Byrne, MD, chief medical advisor at the Muscular Dystrophy Association and director of the Powell Gene Therapy Center at the University of Florida, discusses newly published consensus guidelines from the MDA and Parent Project Muscular Dystrophy on the safe delivery and monitoring of gene therapy in Duchenne muscular dystrophy (DMD). Byrne explains the rationale behind convening a global panel of experts, emphasizing the need for standardized practices in patient selection, administration, and follow-up care as gene therapy becomes more widely available. He highlights the importance of expanded multidisciplinary teams—including hematology, cardiology, nephrology, and immunology—in managing immune-related safety concerns, with particular attention to monitoring liver inflammation and emerging strategies such as rapamycin use. In addition, Byrne outlines how these guidelines address real-world challenges around access, including geographic barriers, language considerations, and financial constraints, while underscoring their role in shaping future gene therapy approaches as additional therapies move through development. Looking for more Neuromuscular discussion? Check out the NeurologyLive® Neuromuscular clinical focus page. Episode Breakdown: 1:00 – Why consensus guidelines were needed for gene therapy in DMD 2:10 – Top-line clinical considerations from the published recommendations 4:30 – Protocols for monitoring and managing adverse events, especially liver toxicity 6:30 – Neurology News Network 8:30 – Addressing health equity, language access, and financial barriers in gene therapy care 12:00 – How these recommendations may shape the future of DMD treatment The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Efgartigimod Aims to Become First Therapy for Seronegative Generalized Myasthenia Gravis Following Positive Phase 3 Data FDA Approves Lecanemab Autoinjector, Marking First At-Home Treatment for Alzheimer Disease Eisai Submits sBLA for Weekly Subcutaneous Lecanemab as Starting Dose Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

Since we just had the Labor day weekend, we thouth we would go back in time and visit about the incredible Jerry Lewis Labor day MDA telethon we grew up watcging!

Steve Oldham is a prominent entrepreneur and carbon removal advocate. He currently serves as CEO of Captura where he is leading the commercialization of Direct Ocean Capture – a climate solution that combines innovative technology with the natural carbon removal powers of the ocean to remove CO2 from the atmosphere at scale.Steve's career has focused on bringing ground-breaking technologies to market in a variety of domains, including robotics, aerospace, and climate. Steve was previously CEO of leading Direct Air Capture (DAC) company, Carbon Engineering, where he grew the company from ~15 to ~150 people, and established the partnership with Occidental that led to their acquisition of Carbon Engineering in November 2023.Steve also served as Senior Vice President, Strategic Business Development for MDA, a leading Canadian technology firm. At MDA, Steve held a variety of senior executive positions across Canada and the US, covering General Management, Business Development, and Strategy, and secured financing from Government and commercial sources for a variety of complex technologies, including several large satellite programs.⁠https://capturacorp.com/⁠⁠https://nexuspmg.com/⁠

WGN Radio's Dave Plier and Dave Schwan talk about the history of the American labor movement as well as the legacy of comedian Jerry Lewis and what was an annual tradition on Labor Day weekend, the MDA telethon.

Our guest this week is Tom Sander of Charlotte, NC a territory account manager at Liquidia Corporation, a rare disease bio pharma company, and father of three including a daughter with Charcot-Marie-Tooth Syndrome, a rare form of Muscular Dystrophy. Tom and his wife, Julie, have married for 22 years and are the proud parents of three children: Will (22), and twins: Jack (18) and Lily (18) who has Charcot-Marie-Tooth Syndrome, which is a type of Muscular Dystrophy that is a spectrum of nerve disorders.    From a very young age Lily has been speaking in public about her condition and how it's affected her and others.  She was selected this past year to be one of two national ambassadors for the Muscular Dystrophy Association. We'll hear all about the Sander famiy story on this episode of the SFN Dad To Dad Podcast. Show Links - Phone – (803) 493-7744Email – tfsander2@gmail.comLinkedIn –  https://www.linkedin.com/in/thomas-sander-30977b12/MDA Website – https://www.mda.org/press-releases/2025/mda-announces-2025-mda-national-ambassador-lily-sanderCharcot-Marie-Tooth Association - https://www.cmtausa.org/Charcot-Marie-Tooth Research Foundation - https://cmtrf.org/YouTube – 2025 Ambassador https://www.youtube.com/watch?v=stJElfj7uqg&t=11sInstagram Video Burn Bootcamp Be Our Muscle - https://www.instagram.com/p/DIRIv74ODkt/ Special Fathers Network -SFN is a dad to dad mentoring program for fathers raising children with special needs. Many of the 800+ SFN Mentor Fathers, who are raising kids with special needs, have said: "I wish there was something like this when we first received our child's diagnosis. I felt so isolated.  There was no one within my family, at work, at church or within my friend group who understood or could relate to what I was going through."SFN Mentor Fathers share their experiences with younger dads closer to the beginning of their journey raising a child with the same or similar special needs. The SFN Mentor Fathers do NOT offer legal or medical advice, that is what lawyers and doctors do. They simply share their experiences and how they have made the most of challenging situations.Check out the 21CD YouTube Channel with dozens of videos on topics relevant to dads raising children with special needs - https://www.youtube.com/channel/UCzDFCvQimWNEb158ll6Q4cA/videosPlease support the SFN. Click here to donate: https://21stcenturydads.org/donate/Special Fathers Network: https://21stcenturydads.org/  SFN Mastermind Group - https://21stcenturydads.org/sfn-mastermind-group/

O ministro falou sobre o papel da agricultura familiar na saída do Brasil do Mapa da Fome das Nações Unidas. A recriação do MDA, em 2023, após o desmantelamento da pasta por Bolsonaro, foi fator essencial para impulsionar as políticas públicas voltadas à segurança alimentar e à promoção da agricultura familiar no Brasil.

The Justice Department has arrested a Defense Department employee for removing classified documents from a Missile Defense Agency office in Huntsville, Alabama. Ewa Ciszak made her initial appearance in federal court Monday. Beginning in February, the FBI says Ciszack began taking classified documents from MDA facilities without authorization. A June 18 search warrant turned up multiple secret-level documents at her personal residence and in her vehicle and backpack. Ciszak had been employed at MDA since January 2023. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Wilbur Wilde (born Nicholas Robert Aitken on 5 October 1955) is an Australian saxophonist, television personality and radio presenter. He is best known for his work on Hey Hey It's Saturday. He rose to prominence with the bands Ol' 55 and Jo Jo Zep & The Falcons.  Music career Wilde was the tenor saxophonist (and did some vocals) with Ol' 55 from 1975 until 1977. Wilde then joined Jo Jo Zep & The Falcons in 1977 as saxophonist and backing singer. He still remains in that role to this date. Television career He is most famous for appearing as part of the house band on Hey Hey It's Saturday, from 1984 until 1999, and again from 2009 until 2010. Wilde has made numerous other TV appearances throughout his career on shows including The Flying Doctors, MDA, The Paul Hogan Show, Blankey Blanks, Sale of the Century, Celebrity Squares, MTV, Getaway, Postcards, Prisoner, Temptation, Spicks and Specks, The Russell Gilbert Show, and commercials for the Australian Pensioners Insurance Agency. From 1992 to 1999, Wilbur toured with The New Rocky Horror Show, contributing to more than 750 performances along the way. His CV also boasts a string of movie credits including Trogan Warrior, Mad Max, The Coolangatta Gold, City of the Damned, Jenny Missed Me, Dead End Drive-In and Cool Change. Radio career Between 2000 and 2004, Wilde presented the Classic Cafe on Gold 104.3 Melbourne. In December 2005, Wilde joined Vega 91.5, hosted a drive show, The Wilbur Wilde Drive, between 3 - 6pm. departing the station in 2008. Wilde also previously presented radio shows at 3UZ and 3XY.

Not sure what Minimal Disease Activity or MDA is and how it relates to psoriatic arthritis and your joints? Listen as rheumatologist Dr. Arthur Mandelin explains what MDA means. Join hosts Jeff Brown and LB Herbert as they discuss minimal disease activity in psoriatic arthritis with nationally recognized rheumatologist Dr. Arthur Mandelin who identifies what it is, factors that influence achieving MDA, how long it takes to reach, and the impact on selection of treatments. Dr. Mandelin also addresses fatigue associated with inflammation, and what the future holds for minimal disease activity in psoriatic arthritis. Whether you have psoriasis or psoriatic arthritis, this episode offers information to help you understand management goals set by your doctor and the importance of attaining minimal disease activity. Timestamps: (00:00) Intro to Psound Bytes & guest welcome rheumatologist Dr. Arthur Mandelin (02:23) What is minimal disease activity (MDA) (04:32) MDA in comparison to ACR response criteria (07:36) Criteria for reaching MDA (09:20) Positive and negative factors of MDA (11:25) Importance of reaching MDA within a specific time frame (17:34) Length of time to reach MDA (18:48) Selection of treatment options and psoriatic arthritis domains (23:51) Inflammation and fatigue (26:59) A look at the future of minimal disease activity in psoriatic arthritis: Reaching ACR 90 (29:09) Advancements in psoriatic arthritis: Finding disease markers (33:40 ) If you have psoriasis, be aware of your risk for psoriatic arthritis 4 Key Takeaways: There are various ways to measure minimal disease activity in psoriatic arthritis to assess how the disease impacts quality of life.   Attaining and keeping minimal disease activity low through use of different therapy options offers a chance for better bone and joint outcomes. Advancements in psoriatic arthritis include attaining ACR90 and the potential for identifying key markers that make treatment selection more targeted and individualized. Those who have psoriasis need to realize bone and joint pain, and swelling in the joints may be related to their psoriatic skin disease and seek appropriate help.  Guest Bio: Dr. Arthur Mandelin is an Associate Professor of Medicine at Northwestern University Feinberg School of Medicine and the Department of Medicine Division of Rheumatology. Dr. Mandelin launched Northwestern University's first training program in musculoskeletal ultrasonography for rheumatology fellows. He is an active participant in the REASON Group which is a multi-center research collaboration devoted to using ultrasound guidance to obtain minimally invasive synovial tissue biopsies. Dr. Mandelin is a past member of the National Psoriasis Foundation's Medical Board where he served on consensus panels for the development of a variety of practice guidelines.  Resources Mentioned: National Psoriasis Foundation: https://www.psoriasis.org PEST Screener: https://www.psoriasis.org/psoriatic-arthritis-screening-test/ PsA Action Month 2025: https://www.psoriasis.org/psa-action-month/ NSAIDS  for Psoriatic Disease: https://www.psoriasis.org/advance/nsaids-for-psoriatic-disease-psa/ AMP (Accelerated Medicines Partnership): https://www.psoriasis.org/advance/progress-and-success- through-collaboration/  Tags: psoriasis, skin, psoriatic arthritis, minimal disease activity, ACR20, ACR50, ACR70, tender joints, bone erosion, joint swelling, enthesitis, inflammation, pain, fatigue, axial disease, spinal involvement, treatment, NSAIDS, biologics, personalized medicine, dermatology, National Psoriasis Foundation, AMP, Psound Bytes podcast, Soundbites podcast

Today on part one of the Rarified Heir Podcast we are talking to Howard Murray, son of comedian and actor Jan Murray. Our conversation with Howard was wide ranging and fun with a few poignant moments we did not see coming. Howard was an effusive and eager guest who really seemed to enjoy talking about his parents and how wonderful they were. This is something we already knew and we get to that when host Josh Mills tells a story about Howard's mother, Toni Murray that we've never told before. Our conversation often harkens back to Howard's beloved early years in Rye, New York when his father was known for his Borscht Belt years in the Catskills mountains entertaining Jewish vacationers, his years on radio and the early years on television in New York City, not far from his hometown of the Bronx. We talk game shows Jan Murray hosted and sometimes created, meeting ‘uncle' Jerry Lewis at his MDA telethon on stage and hearing first hand tales about comics like Sid Caesar, Shecky Greene, Harry Ritz, Buddy Hackett and more. This is the Rarified Heir Podcast and there is nothing like hearing about growing up a child of a celebrity, when your father is as terrific as Jan Murray clearly was. (And Toni Murray wasn't chopped liver either)….and this is just part one.

Send us a textBart Vale Career Deep Dive Ep 273Bart Vale is considered to be one of the few Americans to be on the ground floor of the Japan MMA explosion. Bart Vale takes us through his time with New Japan Pro Wrestling (NJPW) which include a famous confrontation with Ken Shamrock. BIG thank you to William Colosimo who helped us with understanding a time period that is largely undocumented. Bart Vale Career Deep Dive Ep 273  0:00 plugs/ promotions 0:42 Lytes out intro 1:14 Joey Venti's guest introduction1:39 interview start 2:17 beginnings in Martial arts 3:24 Frank Dux 4:29 Rob Van Clief 5:00 moving to Japan to train 10:52 lying about age to seem younger 11:50 issues with Ed Parker 16:06 UWF closing down due to argument 18:40 becoming tired of living in Japan 19:34 closed door fight rumor with Kimura20:40 training with the Machado's 23:50 experience with Soranaka24:27 Karl Gotch fight story 27:02 experience with Gene LeBell 29:11 almost no showing MDA event 31:27 current life 32:39 owning the term “Shoot Fighting” 32:53 underground fights being a shoot 38:28 Pride FC roots 42:12 bringing Ken Shamrock to train 46:52 difficulty dealing with Ken Shamrock 50:04 Ken Shamrock lying about using steroids 51:24 Shoot wrestling match with Ken Shamrock56:04 Mafia involvement in the fight business 57:28 Road Warriors story 58:35 Corporal Kirchner getting arrested 1:00:55 interview with William Collasium 1:01:55 Shoot Fighting Florida1:05:22 dealing with Marcus Marinelli1:11:10 Suzuki and Funaki left Fujiwara and started Pancrase1:13:58 World Combat Championships1:18:21 inviting Jerry Flynn to fight on WCC card 1:19:40 Erik Paulson vs James Warring 1:21:00 experience with Manager Max Coates1:22:56 experience with John Perretti 1:24:23 Bart Vale vs Dan Severn 1:26:49 Don the dragon Wilson 1:27:10 bodyguard for Michael Jackson 1:30:06 Julio Iglesias1:30:50 interview wrap up 1:31:06 outro/ closing thoughts Subscribe to the Lytes Out Podcast:https://www.youtube.com/@MMAHistoryPodcastDiscord:https://discord.gg/s3mV6wyNgvSocials: Facebook -https://www.facebook.com/groups/1027449255187255/?mibextid=oMANbwInstagram - https://www.instagram.com/lytesoutpodcast/iTunes - https://podcasts.apple.com/us/podcast/lytes-out-podcast/id1568575809 Spotify - https://open.spotify.com/show/3q8KsfqrSQSjkdPLkdtNWb Mike - The MMA Detective - @mikedavis632 Cash App - $mikedavis1231Venmo - Mike-Davis-63ZELLE: Cutthroatmma@gmail.com / ph#: 773-491-5052 Follow the #LOP team on Instagram: Chris Lytle - Founder/Owner - @chrislightsoutlytle Mike Davis - MMA Detective - @mikedavis632 Joey Venti - Assistant - @aj_ventitreTyson Green - Producer - @ty.green.weldingAndrew Mendoza - Timestamps - @ambidexstressAndy Campbell - Social Media Manager - @martial_mindset_Josh Campbell - ContributerJohn Perretti - Historical ContributerOutro song: Power - https://tunetank.com/t/2gji/1458-power#MMA #UFC #NHB #LytesOutPodcast #LytesOut #MixedMartialArts #ChrisLytle #MMADetective #MikeDavis #MMAHistory #OldSchoolMMA #FiftyFightClub #MMAPodcast #FightPodcastSupport the show

From quiet questions to Capitol Hill calls: Discover how any voice can ignite disability advocacy. In this episode of the Water Prairie Chronicles, host Tonya Wollum welcomes back Ally Pack-Adair, a passionate advocate and ambassador for the MDA.

Moms Demand Action is one of the most active and viral anti-gun groups in America. They regularly lobby, march, and demand that you give up your guns to make our country “safer.” Today's guest is not having it. She is tired of MDA presuming to speak for all women and mothers, and she is telling a very different story about our Second Amendment rights. -----⭐ SPONSOR: Good Ranchers Good Ranchers offers 100% American meat, protecting you from tariff-related price increases and their vacuum-sealed, individually wrapped cuts reduce food waste, saving families an average of $500 a year.

In this episode of the PCOS Repair Podcast, you'll discover how targeted nutritional supplementation can help reduce oxidative stress and improve hormone and metabolic function in women with PCOS. This discussion is based on a recent research article titled The Effects of Nutritional Supplementation on Oxidative Stress and Hormonal and Lipid Profiles in a PCOS-Affected Female. If you've been wondering whether certain nutrients—like vitamin D or omega-3s—can actually help with PCOS symptoms, this episode breaks it down in a practical and research-backed way.Oxidative Stress and PCOSOxidative stress is a type of internal cellular stress caused by an imbalance between free radicals and antioxidants in the body. It's not the kind of stress you feel emotionally, but rather the kind that leads to cellular damage and accelerates aging. In PCOS, oxidative stress is particularly concerning because it contributes to insulin resistance, increased androgens, chronic inflammation, and even fertility issues. It can also impair egg quality and affect ovulation, adding another layer of complexity for women trying to conceive.Oxidative Stress Biomarkers (Labs)This research highlights a few key biomarkers to assess oxidative stress levels, including malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione (GSH), and nitric oxide (NO). Each of these indicators can help reveal the degree of oxidative damage in the body and how effectively your systems are working to counteract it. In women with PCOS, these markers are often out of balance, showing both elevated oxidative damage and diminished antioxidant defense.Supplements That Help Reduce Oxidative StressThis episode explores several key nutrients that play a powerful role in reducing oxidative stress for women with PCOS. These nutrients help lower inflammation, support metabolic function, and improve insulin sensitivity—all of which are essential for hormone balance. Some have been shown to lower testosterone levels and enhance the body's ability to manage blood sugar, while others support thyroid health and overall inflammation regulation. Some nutrients promote gut health, which is closely tied to hormone regulation, and even those that support better sleep while offering antioxidant benefits that may positively influence fertility. One of the most exciting findings from this study is the suggestion that certain nutrients can influence how genes express themselves. Some support IGF-1 levels, which are important for egg development and ovulation, while others impact insulin sensitivity through specific genetic pathways. There's also evidence that certain nutrients may reduce the expression of genes involved in chronic inflammation. While more research is needed, this emerging science highlights the potential for nutrition to make meaningful changes at a cellular level.Supplements in Your PCOS StrategyNo one supplement will fix PCOS, but using the right nutrients can significantly reduce oxidative stress and improve hormone function. As always, quality matters. Choose third-party tested brands and remember that supplements should complement, not replace, lifestyle interventions.If you're looking for trusted supplement recommendations, you can download the free PCOS The Supplement Guide. I've included a list of high-quality brands and tips for getting started. Improving oxidative stress through nutrition is a powerful tool for managing PCOS. From fertility to energy levels to long-term hormone balance, this episode offers a fresh perspective on what's possible with the right support.You can take the quiz to discover your root cause here.

Markets hate uncertainty, and it’s showing. We break down the recent volatility, from the steep drawdowns in the Nasdaq and S&P 500 to the tariff-fueled market jitters. We also discuss why knowing what you own and being diversified is so important when markets are volatile. We also talk about how the recent volatility is creating opportunities for investors with capital to deploy. We highlight stocks on our radar, including TFII, CP, Nvidia, American Express, Costco, and Amazon, and discuss what makes them interesting at these levels. Plus, why sometimes market moves have a clear reason—like tariffs or earnings surprises—and sometimes, why the reason is not as obvious. Tickets of stocks/ETFs discussed: TFII.TO, CP.TO, NVDA, AXP, COST, AMZN, MDA.TO, TMO, QXO, KSI.TO, EQB.TO, NET Check out our portfolio by going to Jointci.com Our Website Canadian Investor Podcast Network Twitter: @cdn_investing Simon’s twitter: @Fiat_Iceberg Braden’s twitter: @BradoCapital Dan’s Twitter: @stocktrades_ca Want to learn more about Real Estate Investing? Check out the Canadian Real Estate Investor Podcast! Apple Podcast - The Canadian Real Estate Investor Spotify - The Canadian Real Estate Investor Web player - The Canadian Real Estate Investor Asset Allocation ETFs | BMO Global Asset Management Sign up for Finchat.io for free to get easy access to global stock coverage and powerful AI investing tools. Register for EQ Bank, the seamless digital banking experience with better rates and no nonsense.See omnystudio.com/listener for privacy information.

Susanna Doyle from MDA talks about her approach to connecting and communicating with nonprofit donors.

Exploiting the poker strategy of GTO vs PTO at low stakes cash games. Notes are below. Fans of the Pod get ad free, fluff free episode every single Sunday: https://lowlimitcashgames.com Save 10% when you choose the annual option Targeted Low Stakes poker training with hundreds of hours of audio and video teaching exclusively how to crush 1/2 and 1/3 no limit: https://lowlimitcashgames.com Save 10% when you choose the annual option. Hate AK? How to Play AK Master Class For only $49 get this 88 minute training video of me showing you exactly how to play AK, particularly when out of position. https://www.patreon.com/lowlim... The best way to ramp your game up and know how to play any hand in any spot by drilling it over and over again. This is the only product I endorses. Make sure to use my code for a 25% discount at checkout: https://advancedpokertraining.... Use code: lowlimit Want more details on everything that is offered with the training package on Patreon? I go into great detail about it all here: https://podcasts.apple.com/us/... GTO or PTO? GTO - game theory optimal. Learning how to play in such a way that nobody can exploit you. Downsides. Most people that try to learn it don't. Because it's very hard. And even those that come close don't understand how to deviate to exploit others. So they are winning the minimum most of the time. PTO - Population Theory Optimal or Pool Theory Optimal. Learning the habits and tendencies of the pool of players you play in and creating strategies against them as a group and individually to maximally exploit them. Downsides: if any of them ever smarten up and decided to exploit you getting out of line they could wreck you. This just isn't going to happen at 1/2 or 1/3 stakes. And if anyone is capable of doing it you will know who they are very quickly and not fall prey to that. Online coaching gurus are doing this with databases bought or collected from online play. It's called mass data analysis or MDA. In live play you don't have a database other than the one you collect in your brain by playing. So you can't get it by either playing for many many years. Or by being taught by someone who has.

#361"The lensing effect of the window."Roundtable2024.08.22It's hot in the clubhouse and hot in Ellen's greenhouse this week, so your hosts are eager to crunch through some discussion. Ellen introduces the concept of the MDA framework, and the differences between Theming and Aesthetics, and Stephen comes to a major conclusion about parrying.Theming vs. Aesthetics0:06:40Ellen Burns-JohnsonGame DesignThe MDA Framework - WikipediaEllen promised Dictionary.com definitions, so here you go:Aesthetics - Dictionary.comTheme - Dictionary.comWe talked about theming and aesthetics for a GameJam Game from a previous episodeThe Bike BoomAlien Isolation Themes explored n : Demystifying the Terror of Alien Isolation - Andy Robertson, WiredParries0:28:56Stephen McGregorGame DesignStephen's list of why parries are so popular: 1) A way to reward mastery or paying attention 2) Rewards participation 3) An appreciable way to consider mastering the game The different variations of Parrying 1) Just Dodges 2) Traditional Parrying (miss = block) 3) Dynamic Parrying release parrying 4) Alternate button (paper mario parrying) EVO Moment 37 - Wikipedia

** Join the MDA: ⁠michigandental.org/2025⁠ In this episode of the Dental Download Podcast, Dr. Haley reflects on her personal and professional goals for the upcoming year. She discusses her achievements from 2024, including her reading goals and life events, and shares her vision board's impact on her aspirations. Dr. Haley outlines her goals for 2025, focusing on personal growth, financial planning, and maintaining a healthy work-life balance. She expresses gratitude for her podcast community and encourages listeners to share their experiences. Engage with the podcast on Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dentaldownloadpodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠ Haley's Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dr.haley.dds⁠⁠⁠⁠⁠⁠⁠⁠⁠ 

Amy Shinneman was born with Muscular Dystrophy but wasn't diagnosed until the age of 44. During this episode, we talk about: How her and her husband, Jamie, did the 50th year at Berlin and NYC … maybe Marine Corps Marathon in 2025? Tokyo in 2027? All about the Berlin Marathon and getting to Europe for the first time  Tackling the World Majors and how they're thinking about it  Living undiagnosed with a rare form of Muscular Dystrophy for 44 years  What it was like becoming a mom with an (unknown) disability  How she finally got a diagnosis of Bethlem Myopathy and how life was different after The MDA and the work she's done with them  What it's like being a mom with a disability     How her husband, Jamie, got into running because of their kids  Getting a duo bike from MDA and doing her first marathon with her husband pushing at the Chicago Marathon  How her son finished third in his age group at the New York City Marathon and received a Tiffany's plate    Race experiences and what she keeps in the duo bike during a race  How one of her sons taught her to run on an underwater treadmill  Using stem cell therapy as a way to treat MD The mental health side of having a disability  “Once you've met a person with a disability, you've met one person with a disability” The fact that people judge her (and have screamed at her) for parking in an accessible parking spot Thank you to Fringe Heals for supporting this episode. Use code ALLY25 for 25% off your order through 12/31/24. This is a SandyBoy Productions podcast.

In this week's season finale Kim and Kate are joined by Amy Poeher and they ask her some hard hitting gotcha questions and also order lunch. Then, they answer a question from an emailer who wants to be promoted but isn't sure it's going to happen. Then, Kim's mom finally makes her MDA debut and asks a question about when it's time to retire. Everyone's lives are changed forever and the workplace is improved for all involved. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

A clandestine chemistry interview unlike any other, this is the story of a man whose chemistry education was paid for by an organized crime ring. After learning the necessary skills, he was tasked with synthesizing increasingly large quantities of MDA under ever-rising pressure until the entire operation exploded.100s of unreleased episodes available at patreon.com/hamiltonmorrisMerchandise available at hamiltonmorris.comKykeon Analytics A fully anonymous mail-in drug checking lab service. CannaclearGet 15% off with the code HamiltonLucy Tobacco Free NicotineLucy's mission is to reduce tobacco-related harm to zero.Matcha.comAndrew Weil MD's matcha tea company. Use the code "Hamilton" for up to 20% off + a FREE gift.New BrewA delicious, euphoric seltzer.Top Tree Herbs Kratom Tea BagsTop Tree Herbs is the first kratom tea bag companyHamiltonMorris.comLimited Stock in Exclusive Hamilton Morris Podcast MerchandiseDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the show

** Join the MDA: michigandental.org/2025 In this conversation, Dr. Rachel Shaw shares her journey in dentistry, from her educational background at Midwestern University to her experiences as an associate and eventually becoming a practice owner. They discuss maternity leave as a dentist and balancing sharing the parenting load with your partner. She discusses the challenges of balancing family life with her career, the importance of mentorship in her early years, and her approach to patient care. Dr. Shaw also reflects on the impact of social media in changing perceptions of dentistry and offers advice for pre-dental students and new dentists navigating their careers. Dr. Rachel's tiktok: https://www.tiktok.com/discover/dr-rachel-dentist Engage with the podcast on Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dentaldownloadpodcast⁠⁠⁠⁠⁠⁠⁠ Haley's Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dr.haley.dds⁠⁠⁠⁠⁠⁠⁠ 

Join the MDA now**: www.michigandental.org/2025 In this engaging conversation, Dr. Haley and Dr. Chad discuss the evolution of Centerville Family Dentistry (CFD), the importance of community and patient relationships, and the mission that drives their practice. They explore the challenges and rewards of dentistry, emphasizing the need for effective communication with patients and overcoming barriers to health. The episode concludes with a reflection on the journey so far and a hint at future discussions. Be sure to subscribe to the podcast to see part 2 coming in the future where we dive deep into who Dr. Chad is as an individual and as a dentist! Our practice: https://www.smilecentreville.com/ Engage with the podcast on Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dentaldownloadpodcast⁠⁠⁠⁠ Haley's Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dr.haley.dds⁠⁠⁠⁠ 

Episode Highlights: Mindy Henderson, a powerful advocate for disability rights and the Director & Editor-In-Chief of MDA's Quest Media. Mindy shares her journey of breaking barriers in the skies, working tirelessly to make air travel more accessible for wheelchair users and the broader disability community. She delves into practical tips for navigating travel with a wheelchair-using child, explains the importance of universal design, and discusses how sharing your story can be a catalyst for change. Mindy also talks about her book, The Truth About Things That Suck, and the role of mindset in overcoming adversity. Packed with inspiration and actionable advice, this episode is a must-listen for anyone looking to make the world more accessible, one step—or one flight—at a time. Links: Connect with Mindy Henderson on LinkedIn: LinkedIn Profile Learn more about MDA Quest: mdaquest.org Mindy's book - The Truth About Things That Suck: Amazon Link Tammy Duckworth - Every Day is a Gift: Amazon Link Get Involved and Take Action: Share your story on social media to raise awareness. Join disability advocacy groups to support accessible travel policies. Tune in and join us in supporting accessible, inclusive travel! Airplane Travel Tips from a One Million Mile Traveler The recent passage of the FAA Reauthorization Act

** ⁠Join the MDA now! - michigandental.org/2025⁠ In this episode of the Dental Download Podcast, Dr. Haley shares her experiences and insights from her journey through dental school and into her early career as a dentist. She discusses the importance of community, personal growth, and the lessons learned along the way. Dr. Haley emphasizes the significance of asking for opportunities, maintaining a work-life balance, and the value of being prepared for when opportunities arise. She also provides advice for students and young professionals in the dental field, encouraging them to embrace their unique selves and seek support from their communities. Engage with the podcast on Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dentaldownloadpodcast⁠⁠⁠⁠ Haley's Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dr.haley.dds⁠⁠⁠⁠  Make your podcast on Riverside: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.riverside.fm/?utm_campaign=campaign_5&utm_medium=affiliate&utm_source=rewardful&via=haley Keywords: Dental Download Podcast, Dr. Haley, dental school advice, personal growth, community support, work-life balance, financial planning, fitness recommendations, MSU, dental career

Learn more about MDA memberships: www.michigandental.org/2025 In this conversation, Dr. Lisenia Colazzo shares her journey from Pennsylvania to Puerto Rico and then to Michigan, where she serves as a public health dental director. She discusses the importance of organized dentistry, the challenges of access to care in rural areas, and her advocacy work within the Michigan Dental Association. Dr. Colazzo emphasizes the need for community engagement and the empowerment of patients through education and improved access to dental care. She also shares personal insights on balancing her professional and personal life, including her love for travel and reading. Keywordspublic health, dentistry, organized dentistry, access to care, community health, leadership, advocacy, dental education, underserved communities, Michigan, Michigan Dental Association

In this powerful episode, Tah shares insights from the Sex & Psychedelics panel hosted by the Psychedelic Society of Texas on September 19, 2024. Joined by a dynamic group of experts, including Danielle Arbery Smith, Ashley Carmen, and Drea Aguilar, the discussion dives deep into the intersection of sex and psychedelics. Together, they explore how altered states can enhance intimacy, facilitate profound healing, and reprogram deep-seated traumas. Topics include setting boundaries before engaging in psychedelic or sexual experiences, creating safety, and how psychedelics can unlock new levels of personal and relational awareness. Whether you're curious about psychedelics or exploring how to integrate them into intimate relationships, this episode provides valuable tools and insights. Tune in for a raw, unfiltered conversation on the power of psychedelics to transform the way we connect with ourselves and others. Key Takeaways: How psychedelics can rewire trauma and enhance intimacy The importance of boundaries and intentional preparation Personal stories of healing and growth through sex and psychedelics Practical advice for couples and individuals exploring altered states Disclaimer: This podcast is for informational and educational purposes only. It is not intended as medical advice. Please consult with a healthcare professional before engaging in any practices involving psychedelics or sexual health. Featured Guests of this Episode: Danielle Aubrey Smith @DanielleAubreySmith Ashley Carmen @theashleycarmenjourney @psychedelicguidenetwork  www.psychedelicguidenetwork.com    Drea Aguilar @conscious.mother Psychedelic Society of Texas www.psytexas.com @psytexas AstUs Co @Artuscoart   You've been introduced to the world of psychedelics and plant medicine - but you're left wondering, “Okay, now what?” Become a Psychedelic-Informed Practitioner Because integration is NOT optional. Boundary Blueprint Course Visit Our Home on the Web, get more information and join The Condor Approach Take our Free Audio Course on Psychedelic Integration Download Our 7-Day Integration Guide FREE Follow Us on Instagram for All things Condor Approach Follow Kole on Instagram Follow Tah on Instagram

This week on Dopey! In a super special new Dopey! We are joined by one of the greatest Dopey storytellers in the history of the show! Louie Mandrapillias - the gay weed kingpin of Houston tells a Dopey story unlike all Dopey stories which starts innocently enough in Shreveport Louisiana and winds up in India smuggling heroin back to New York City up his butt in a dildo shaped  condom. There are too many incredible Dopey stories to ruin in this description! PLUS voicemails from Australia, a letter from prison and so much more in a super extra special new episode of the good old Dopey Show! NOTES! - MDA and studio 54 - speedballs - trafficking drugs from india - opium den - bhagwan compound - smuggling heroin in a condom - DEA search at the airport - projecting drug use onto random people when you're high - bolivian cocaine, getting caught - avoids jail time with nepotism - heroin from bangkok smuggling tek - HIV positive - spontaneous recovery awakening - LA AA scene