Podcasts about serratia

On episode #73 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/16/25 – 1/29/25. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral AGA clinical practice guideline on the prevention and treatment of hepatitis B virus reactivation (Gastroenterology) Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients (Nature Communications) Insect-specific RNA viruses detection in Field-Caught Aedes aegypti mosquitoes from Argentina using NGS technology (PLoS Neglected Tropical Diseases) Bacterial Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis (NEJM) Impact of antibiotic treatment and predictors for subsequent infections in multidrug-resistant Pseudomonas aeruginosa catheter-associated asymptomatic bacteriuria (American Journal of Infection Control) Identification of the skip phenomenon among patients With Staphylococcus lugdunensis infective endocarditis (OFID) Emergence of infective endocarditis due to Serratia spp. (OFID) Reduction of vancomycin-associated acute kidney injury with montelukast (JID) Fungal The Last of US Season 2 (YouTube) Pulmonary co-infection of Pneumocystis jirovecii and Aspergillus species (OFID) Impact of fluconazoleon outcomes of patients with primary pulmonary coccidioidomycosis (CID) Parasitic Comparative outcomes of Babesiosis in immunocompromised and non-immunocompromised hosts (CID) Miscellaneous Hidradenitis suppurativa (LANCET) A severe case associated with mixed infections of Pasteurella multocida, Bacteroides pyogenes and Fusobacterium necrophorum due to a snow leopard bite (CMI: Clinical Microbiology and Infection) INSIDE-OUT: Introduction of speakers at IDWeek events (OFID) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

Music licensed from Lickd. The biggest mainstream and stock music platform for content creators.Leave Your Love Again by William Davies, https://t.lickd.co/NykJOQL5ZlK License ID: 6pLEyNd3L38If you want to use music from famous artists, try Lickd to get track credits and unlimited stock music: https://app.lickd.co/r/2499b92c963c4df295ab0375c59aab2fRichard Warren Beckwith is a highly accomplished attorney with a diverse and eclectic backgroundspanning law, molecular biology, and media. Currently serving as the City Attorney for Rock Springs,Wyoming, he brings a wealth of experience and expertise to his role. He is the Wyoming State Directorfor the Mutual UFO Network (MUFON) and a member of the MUFON International Board of Directors. Heis also the host of the Official MUFON Podcast. He has been investigating UFOs for more than fifty years,and professionally for nearly twenty.Beckwith earned a Bachelor of Science Degree in Molecular Biology from the University of Wyoming anda Juris Doctorate from the University of Wyoming College of Law. His legal career has included roles asPrincipal Partner in a prestigious local law firm, General Counsel to Dr. Steven Greer's Orion Project, andLegal Counsel to the MUFON Board of Directors. As a skilled litigator and negotiator, he has handled awide range of legal matters, including:• Criminal Defense• Construction Litigation• Complex Civil Litigation• Real estate Law• Administrative and agency law• Labor and employment law• Non-disclosure agreementsPrior to his legal career, Beckwith worked as a microbiologist studying the leaching of selenium in soil, asa lab technician in a molecular virology lab attempting to isolate a plant protein related to the humanimmune response, as a lab technician in a molecular genetics laboratory searching for the Ori of Serratia;and as a lab technician in an atmospheric microbiology laboratory studying atmospheric bacteriapopulations.His diverse background includes experience as a professional musician and broadcaster, serving as aProgram Director, Production Director, News Director, and Air Personality for numerous broadcastingorganizations.An active member of the legal community, Beckwith has held numerous leadership positions in theSweetwater County Bar Association and is a member of the Wyoming Bar Association and the AmericanBar Association.With his unique blend of legal expertise, scientific knowledge, and media experience, Richard WarrenBeckwith continues to make significant cBecome a supporter of this podcast: https://www.spreaker.com/podcast/night-dreams-talk-radio-with-gary-anderson--2788432/support.

In this episode, we review the high-yield topic of⁠ ⁠Serratia ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

Today Dr. Ken Stedman, Professor of Biology at Portland State University, tells us about the strange and wonderful viruses of heat loving extremophilic archaea—truly viruses from Hell! Host: Mark O. Martin Guest: Ken Stedman Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A popular article about Markus Martin's work as a fossil expert extraordinaire. Markus Martin's website.   One of Markus Martin's academic articles on trilobites. An interesting article on the complexity of colony morphology by Bacillus subtilis. An article about Serratia, prodigiosin, and temperature.   An article I wrote about educational aspects of the work of the late great Carl Woese. An introduction to the diverse and fascinating archaea.   An introduction to the viruses of archaea. Ken Stedman's fascinating laboratory website. Ken Stedman's faculty website. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: "A Creepy Feeling": Nixon's Decision to Disavow Biological Weapons, published by ThomasW on September 30, 2022 on The Effective Altruism Forum. I wrote this paper for a class in December 2021. I had been meaning to put it up on the forum for a while, but only just now got around to it. I found this research useful for my own understanding of the kinds of events that can contribute to dramatic policy changes. At the end I mention the obvious relevance to autonomous weapons regulation, but I think that lessons learned apply to all kinds of regulation of dangerous technologies. In September of 1950, a ship sailed by the Golden Gate Bridge. It carried a stockpile of Serratia marcescens bacteria, which it released in a huge plume over the city of San Francisco. Those onboard hoped to expose as many people as possible to the bacteria. Their mission was a success, and most of the city's residents were exposed. The ship was not operated by a hostile foreign government or terrorist operatives, but by the United States Navy. Though Serratia marcescens is a “simulant” bacterium not known to cause harm, the test showed the potential for attacks with more deadly forms of bacteria. Despite the “benign” nature of the bacterium, Stanford University doctors reported several bizarre cases of urinary tract infections at the time, leading eventually to one death. The test was far from the only biological weapons test conducted in secrecy by the U.S. government from World War II until as late as 1968. On November 25th, 1969, President Richard Nixon gave a speech to the American public following a briefing to Congress. He announced the United States would renounce the use of biological weapons, destroy its stockpiles, and research only what was necessary to defend against possible attacks from enemies. He also voiced support for a United Kingdom initiative to ban biological weapons internationally, which would eventually become the Biological Weapons Convention. How did the United States go from biological weapons testing on its own population to leading the world in opposition to biological weapons? Historians have offered many possible explanations. One common argument is that public pressure forced Nixon's hand. In a 2002 paper, Jonathan B. Tucker, a CBW expert and then a researcher at the Monterey Institute of International Studies, specifically emphasizes television reports in early 1969 and their contribution to increased awareness of the weapons. Brian Balmer and Alex Spelling of University College London conducted a 2016 analysis of contemporaneous newspaper articles about biological weapons, finding that they routinely portrayed biological weapons as dangerous even if they presented mixed messages about their effectiveness. Robert W. McElroy, a prelate of the Catholic church, included a discussion of CBW in a 1992 book, stressing in particular the idea that the public viewed such weapons as morally repugnant. I will argue that public pressure was a significant factor behind Nixon's decision, but that it was not sufficient to convince Nixon that renouncing biological weapons would be safe. A second argument is that international pressure created an environment where the American position was untenable. James Revill, a research fellow at the University of Sussex, wrote in a 2018 article that international arms control was a major factor, while also suggesting that the renunciation may have been an attempt to deflect attention from the Vietnam War as well as a response to the advocacy of international organizations. McElroy also discussed international opposition, again from a moral perspective, and Tucker acknowledged it as well. I will argue that while international developments were important in shaping Nixon's decision, they were not his primary motivation. A third argument was ...

Dr. Don and Professor Ben talk about the risks of eating butter that has turned purple. Dr. Don - risky ☣️ Professor Ben - risky ☣️ What is this purple stuff in my butter dish? : biology Butter Bell | French Butter Crock - YouTube Why the heck did my butter turn purple? - cooking | Ask MetaFilter Purps butter - Imgur First attempt at cannabutter (purple butter) : treedibles Serratia marcescens - Wikipedia Microorganisms | Free Full-Text | What Is Candida Doing in My Food? A Review and Safety Alert on Its Use as Starter Cultures in Fermented Foods Candida glabrata: Review of Epidemiology, Pathogenesis, and Clinical Disease with Comparison to C. albicans - PMC

Videos: Gary Null – Speaks to U.N. on Earth Day (Part 1 & 2) Iain McGilchrist, ‘We Need to Act' Iain McGilchrist is a former Fellow of All Souls College, Oxford, an associate Fellow of Green Templeton College, Oxford, a Fellow of the Royal College of Psychiatrists, a Fellow of the Royal Society of Arts, a Consultant Emeritus of the Bethlem and Maudsley Hospital, London, a former research Fellow in Neuroimaging at Johns Hopkins University Medical School, Baltimore, and a former Fellow of the Institute of Advanced Studies in Stellenbosch. He now lives on the Isle of Skye, off the coast of North West Scotland, where he continues to write, and lectures worldwide.   California's “holy herb” Yerba Santa found to be an effective natural treatment for Alzheimer's   Salk Institute for Biological Studies, September 19, 2022 Alzheimer's disease is the most common form of dementia, and aging is its primary risk factor. Therefore, researchers continue to look for ways to counter the effects of aging on the brain. In a recent study, researchers from The Salk Institute for Biological Studies discovered a potential natural treatment for Alzheimer's in the form of a medicinal herb found in California. In their study published in the journal Redox Biology, they found that yerba santa (Eriodictyon californicum), a plant native to California, contains an active compound called sterubin that could be used to treat people with Alzheimer's. Yerba santa, which is the Spanish for “holy herb,” is highly regarded as a medicine for respiratory diseases, bruising, fever, headaches, infections, and pain. For the current study, the researchers first examined 400 plant extracts with known medicinal properties for their ability to prevent oxytosis – a type of cell death that occurs in Alzheimer's disease – in mouse hippocampal nerve cells. The researchers found that sterubin exhibited the greatest protective effect against inflammation and other triggers of brain cell death. In particular, sterubin strongly reduced inflammation in microglia, which are brain cells that provide support to nerve cells. In addition, the researchers found that sterubin can remove iron from cells, helping to prevent iron accumulation. Iron accumulation can result in a type of nerve cell damage that accompanies aging and occurs in neurodegenerative problems. “Not only did sterubin turn out to be much more active than the other flavonoids in Yerba santa in our assays, it appears as good as, if not better than, other flavonoids we have studied,” said Pamela Maher, the corresponding author of the study. Vitamin B may reduce risk of stroke Zhengzhou University (China)  September 23, 2022   Researchers have uncovered evidence that suggests vitamin B supplements could help to reduce the risk of stroke, according to a study published in the journal Neurology. Vitamin B supplements are said to be beneficial for many health issues, including stress, anxiety, depression, dementia, Alzheimer's disease and heart disease. However, according to Xu Yuming of Zhengzhou University in Zhengzhou, China, previous studies have conflicting findings regarding the use of vitamin B supplements and stroke or heart attack. In order to determine the role of vitamin B supplements in the risk of stroke, Prof. Yuming and colleagues analyzed 14 randomized clinical trials involving a total of 54,913 participants  All studies compared use of vitamin B supplements with a placebo, or a very low dosage of the vitamin. All participants were then followed for a period of 6 months. Results of the analysis revealed that the participants taking the vitamin B supplements had a 7% reduced risk of stroke, compared with those taking the placebo supplements or a low dosage of vitamin B. The researchers found that a supplemental form of folate (vitamin B9) – a vitamin frequently found in fortified cereals – actually reduced the effect of vitamin B on the risk of stroke Additionally, the study showed that vitamin B12 did not have any effect on the risk of stroke.   Ginger may protect the brain from MSG toxicity, says fascinating research University of Jeddah (Saudi Arabia), September 23, 2013  For thousands of years, ginger has been hailed as a superfood for its healing properties that aid every system of the body. The oils that ginger contains are antibacterial, antiviral and antifungal, and ginger has even been found to inhibit cancer growth. Now a study has actually proven that ginger can reverse the damage done by monosodium glutamate, or MSG, a known harmful excitotoxin. After injecting pure MSG into rats for 30 days, researchers found subsequent withdrawal caused adverse effects including significant epinephrine, norepinephine, dopamine and serotonin depletion. Low levels of these important neurotransmitters can be detrimental to health. Subsequent to injecting lab rats with MSG, researchers injected ginger root extract for 30 more days and were able to completely reverse the neurotransmitter depletion and brain damage that MSG caused. Not only that, but the positive effects of ginger were maintained even after scientists stopped administering it! A wealth of independent studies show that MSG should be avoided at all costs. Also popularly printed on food labels as hydrolyzed protein, torula or autolyzed yeast, soy or yeast extract and soy protein isolate among some 40 other names, scientists have found that consuming MSG even in low doses can cause blood glutamate levels to fluctuate abnormally high and then stay there. Anyone suffering from a disease or immunity issue that would contribute to a weakened blood-brain barrier is then much more susceptible to the chemical seeping into his or her brain and doing damage. Studies have effectively linked MSG consumption to several neurodegenerative diseases, such as Parkinson's and Alzheimer's. Men with anxiety are more likely to die of cancer, study says Cambridge University's Institute of Public Health, September 20, 2022 Men over 40 who are plagued with generalized anxiety disorder are more than twice as likely to die of cancer than are men who do not have the mental affliction, new research finds. But for women who suffer from severe anxiety, the research found no increased risk of cancer death. That finding, presented at the European College of Neuropsychopharmacology's Congress in Vienna, emerges from the largest study ever to explore a link between anxiety and cancer. It tracked 15,938 Britons over 40 for 15 years. Even after researchers took account of factors that boost the risk of cancer, including age, alcohol consumption, smoking and chronic diseases, men with a diagnosis of generalized anxiety disorder were 2.15 times as likely to die of cancer than were those with no such diagnosis. Generalized anxiety disorder – a condition marked by excessive, uncontrollable worry about many areas of life – affected women more commonly than it did men. Among women in the large cohort studied, 2.4 percent suffered from the disorder. Among men in the cohort, 1.8 percent did. Whatever the relationship, says the study's lead author, the new findings identify extremely anxious men as a population whose mental and physical health should be closely tracked. “Society may need to consider anxiety as a warning signal for poor health,” said study lead author Olivia Remes of Cambridge University's Institute of Public Health. “With this study, we show that anxiety is more than just a personality trait,” but rather, a disorder linked to real and serious health risks. Out of Over 400 Compounds Analyzed, Red Grapes and Blueberries Are Tops In Boosting Immunity – So Effective They Work As Well As Drugs Linus Pauling Institute at Oregon State University, September 18, 2022Pterostilbene, an antioxidant produced by plants has been shown to exhibit exceptional properties in fighting infections, cancer, hypertriglycerides, as well as the ability to reverse cognitive decline. It is believed that the compound also has anti-diabetic properties. In an analysis of 446 compounds for their the ability to boost the innate immune system in humans, researchers in the Linus Pauling Institute at Oregon State University discovered just two that stood out from the crowd. Red grapes and blueberies both have an exceptional ability to significantly impact immune function. In fact, pterostilbene works as well as some commercial drugs.

Both of these compounds, which are called stilbenoids, worked in synergy with vitamin D and had a significant impact in raising the expression of the human cathelicidin antimicrobial peptide, or CAMP gene, that is involved in immune function.The research was published in Molecular Nutrition and Food Research, in studies supported by the National Institutes of Health.

Almost a decade ago, researchers discovered that pterostilbene helps regulate blood sugar and might help fight type-2 diabetes. The finding adds to a growing list of reasons to eat colorful fruit, especially blueberries, which are rich in compounds known as antioxidants. These molecules battle cell and DNA damage involved in cancer, heart disease, diabetes and perhaps also brain degeneration. 

Pterostilbene works as well as the commercial drug ciprofibrate to lower the levels of fats (lipids) and triglycerides — but they worked even more accurately. They are so specific that side-effects are non-existent.”Out of a study of hundreds of compounds, just these two popped right out,” said Adrian Gombart, an LPI principal investigator and associate professor in the OSU College of Science. “Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It's a pretty interesting interaction.”This research is the first to show a clear synergy with vitamin D that increased CAMP expression by several times, scientists said.The CAMP gene itself is also the subject of much study, as it has been shown to play a key role in the “innate” immune system, or the body's first line of defense and ability to combat bacterial infection. The innate immune response is especially important as many antibiotics increasingly lose their effectiveness.

Grapes don't have to be fermented to contain this antioxidant. It's actually found in the skin of red grapes along with other nutrients, such as minerals manganese and potassium and vitamins K, C and B1.Stilbenoids are compounds produced by plants to fight infections, and in human biology appear to affect some of the signaling pathways that allow vitamin D to do its job, researchers said. It appears that combining these compounds with vitamin D has considerably more biological impact than any of them would separately. Fungus in humans identified for first time as key factor in Crohn's disease Case Western Reserve University, September 22, 2022 A Case Western Reserve University School of Medicine-led team of international researchers has for the first time identified a fungus as a key factor in the development of Crohn's disease. The researchers also linked a new bacterium to the previous bacteria associated with Crohn's. The groundbreaking findings, published in mBio, could lead to potential new treatments and ultimately, cures for the debilitating inflammatory bowel disease, which causes severe abdominal pain, diarrhea, weight loss, and fatigue. Mycology at Case Western Reserve and University Hospitals Cleveland Medical Center “Essentially, patients with Crohn's have abnormal immune responses to these bacteria, which inhabit the intestines of all people. While most researchers focus their investigations on these bacteria, few have examined the role of fungi, which are also present in everyone's intestines. Our study adds significant new information to understanding why some people develop Crohn's disease. Equally important, it can result in a new generation of treatments, including medications and probiotics, which hold the potential for making qualitative and quantitative differences in the lives of people suffering from Crohn's.” The researchers assessed the mycobiome and bacteriome of patients with Crohn's disease and their Crohn's-free first degree relatives in nine families in northern France and Belgium, and in Crohn's-free individuals from four families living in the same geographic area. Specifically, they analyzed fecal samples of 20 Crohn's and 28 Crohn's-free patients from nine families and of 21 Crohn's-free patients of four families. The researchers found strong fungal-bacterial interactions in those with Crohn's disease: two bacteria (Escherichia coli and Serratia marcescens) and one fungus (Candida tropicalis) moved in lock step. The presence of all three in the sick family members was significantly higher compared to their healthy relatives, suggesting that the bacteria and fungus interact in the intestines. Additionally, test-tube research by the Ghannoum-led team found that the three work together (with the E. coli cells fusing to the fungal cells and S. marcescens forming a bridge connecting the microbes) to produce a biofilm — a thin, slimy layer of microorganisms found in the body that adheres to, among other sites, a portion of the intestines — which can prompt inflammation that results in the symptoms of Crohn's disease. This is first time any fungus has been linked to Crohn's in humans; previously it was only found in mice with the disease. The study is also the first to include S. marcescens in the Crohn's-linked bacteriome. Additionally, the researchers found that the presence of beneficial bacteria was significantly lower in the Crohn's patients, corroborating previous research findings.

Join Jame and Callum and they discuss some of the other Enterobacterales Gram negatives. Particularly breaking down them into their families and into Lactose fermenters and non-fermenters. Jame has a small breakdown around our Twitter handle near the end.Comments suggestions and criticisms to idiotspodcasting@gmail.com or @IDiots_pod Some lists:Chromosomal AmpC Carriers (high-risk): HECK YES·         Hafnia alvei, Enterobacter cloacae, Citrobacter freundii, Klebsiella aerogenes, Yersinia enterocoliticaLower Risk Chromosomal AMPC: Vulgar Providencia Store AMPC·         Proteus Vulgaris, Providencia, Serratia, Acinetobacter, Morganella, Providencia Intrinsic Colistin Resistance: ·         Burkholderia cepacia (Nonfermenter), Proteus, Providencia, Serratia Biochemical mimics of Salmonella (also can group)·         Hafnia, Morganella,Proteus Cat 3 organisms: ·         Salmonella typhi/paratyphi, Shigella dysenteriae type 1, E.coli O157, Yersinia PestisSome useful resources:SMI ID 16: identification of Enterobacteriaceaehttps://www.gov.uk/government/publications/smi-id-16-identification-of-enterobacteriaceae Janda JM, Abbott SL. 2021. The changing face of the family Enterobacteriaceae (order: “Enterobacterales”): new members, taxonomic issues, geographic expansion, and new diseases and disease syndromes. Clin Microbiol Rev 34:e00174-20. https://doi.org/10.1128/CMR.00174-20 

In this introductory episode of The Current Cucurbit podcast series, Dr. Gleason (project leader) sketches out our research on mesotunnels as an option for organic growers. Part of the challenge for mesotunnels is to stop two devastating diseases: bacterial wilt (caused by Erwinia tracheiphila) and CYVD (cucurbit yellow vine disease, caused by Serratia marcescens). The podcast explains how mesotunnels can meet this challenge. This series can help you decide if mesotunnels make sense for your farm.

  Florian hat mal wieder ein Buch (co-) geschrieben. Es heißt Die Geschichte der Welt in 100 Mikroorganismen* und wir reden über eine Handvoll davon. Darin: Aschbacher Update und Literaturproduktion – Magnetospirillum gryphiswaldense (Polsprung) – Streptococcus thermophilus (Forensik, Pig-Pen) – Archaeen (Carl Woese) – Methanobrevibacter – Serratia marcescens (Transsubstantiation, Blutwunder) – Fusarium oxysporum (Bananen, Gros Michel, Cavendish) – Planetary […]

As individuals, we are all exposed to a variety of substances on a daily basis, from the foods we eat to the household and hygienic products we use to environmental agents. This constant exposure can cause the bloodstream to become overloaded with allergens, inflammatory agents (e.g., bacteria, fungi, antigens), undigested food, and even fibrin, which is a blood clot-forming protein. The buildup of these types of substances can put a strain on the immune system and subsequently lead to the increased production of pro-inflammatory proteins that can worsen pain or discomfort, making it harder to recover and cause immune hypersensitivity. Certain remedies may cause side effects and even weaken the immune response by design (such as allergy and arthritis medications), while others can target harmful invaders, promote cleansing and detoxification, and strengthen the immune system.One beneficial range of natural remedies that can support a healthy immune and inflammatory response are proteolytic enzymes. Beneficial proteolytic enzymes include peptidase, nattokinase, protease, papain, and bromelain. These enzymes support the complete digestion of proteins from foods, and certain other circulating protein particles. They may even help cleanse the body of harmful toxins and microorganisms.When there is an excessive buildup of undigested food (e.g., sugars, fats, proteins, etc.), toxins, fibrin, and infectious agents, these substances can be transferred to the large intestines or bloodstream where antibodies attach to them and create what are known as circulating immune complexes (CICs). Antibodies bind to undigested food particles and other harmful substances as a means of signaling the immune system to increase the production of white blood cells that can seek out and destroy them. The human body needs food (macronutrients) for energy, growth and repair and to keep warm. We need many nutrients on a daily basis in order to stay healthy. The three main nutrient groups in food are carbohydrates, protein and fats. A normal digestive system can quickly convert macronutrients into micronutrients like amino acids, vitamins, and minerals. A less than optimal digestive system may not properly convert foods into nutrients. This may lead to a condition known as leaky gut (LG). With LG, partially digested foods may enter the circulatory system and begin to decompose into CIC’s. High levels of CICs can put a strain on the immune system and reduce its ability to fight off other infectious agents. Accordingly, CICs are linked to the onset of various complications [8]. More specifically, the accumulation of CICs may cause abnormal cortisol levels as well as chronic systemic inflammation that is associated with the onset of cardiovascular, blood sugar, memory, and even metabolic issues.Peptidase and nattokinase, in particular, target substances that cause fluid accumulation, inflammation, and swelling. This leads to rapid drainage and cleansing away from the affected region. This process also shortens the recovery period. Peptidase is especially unique as this enzyme is produced by non-pathogenic bacteria called Serratia sp. E-15, which is localized in the intestines of silkworms. This powerful enzyme breaks down the walls of the chrysalis that silkworms grow in as they begin to undergo metamorphosis, the process through which they become moths. Based on this discovery, it was proposed that this enzyme is capable of breaking down dead tissue without damaging an organism’s healthy cells. This property heightens immunity by promoting the destruction and detoxification of harmful substances that the immune system is normally tasked with addressing.

Gram negative bacilli - Klebsiella, Enterobacter, Serratia

It’s been a long 10 days and let’s be honest, I have been very busy between the AMOPS conference, clinic, nearly hourly updates in my alternate role as a military guy and then working on the continuous demands of academics at the most awesomest university in the world, Ohio University. If you don’t want to hear my take on movies, then just fast forward to from 14:49 through 21:10. We talk about the following and you will notice that I have considerately provided references for everything I speak about. You’re welcome.  I’ll get new Rotations Content up next Monday. In the meantime, WASH YOUR HANDS! Update OU Shut down https://www.ohio.edu/news/2020/03/president-nellis-provides-critical-update-about-ohios-response-coronavirus https://www.ohio.edu/experts/ask-experts Sorry, it was Serratia, not influenza, in Operation Sea Spray https://www.smithsonianmag.com/smart-news/1950-us-released-bioweapon-san-francisco-180955819/ https://en.wikipedia.org/wiki/Operation_Sea-Spray#:~:text= John’s Hopkins Corona Virus Map. Removed because this was being exploited as a malware vehicle for a trojan virus. Mask pore sizes https://www.researchgate.net/publication/242297437_The_Relationship_of_Fabric_Properties_and_Bacterial_Filtration_Efficiency_for_Selected_Surgical_Face_Masks/figures?lo=1 https://www.moh.gov.sg/docs/librariesprovider5/diseases-updates/interim-pandemic-plan-public-ver-_april-2014.pdf Sizes of particulates https://commons.wikimedia.org/wiki/File:Filtration_Chart.jpg CDC Coronavirus Disease Guidance https://www.cdc.gov/coronavirus/2019-ncov/about/prevention.html AMOPS https://amops.org/ https://www.facebook.com/groups/SAMOPS/ Last Christmas https://en.wikipedia.org/wiki/Last_Christmas_(film) Definitely Maybe https://en.wikipedia.org/wiki/Definitely,_Maybe Crazy Rich Asians https://en.wikipedia.org/wiki/Crazy_Rich_Asians_(film) Knives Out https://en.wikipedia.org/wiki/Knives_Out Catch us on twitter at @RotationsPcast Look for more Rotations Content at mediainmedicine.com Rotations and on iTunes at Rotations Podcast. Intro and Outro Music: There is no Time by Tilman Sillescue Courtesy of artlist.io Produced by: Todd Fredricks @medicalcinema on Twitter and Brian Plow @ProfPlow Edited by: Todd Fredricks Host: Todd Fredricks Cutclip: I didn’t add the cutclip because my wife called and told me she had just made taco salad and so I decided to head home. Plus I really needed a Claritin D…Las Vegas has Tree Pollen and it is not awesome… Rotations is produced using (and we always accept donations from any gear folks): Rode Podcaster Pro Rode NT1-A mics Polsen Studio Headphones Kopul XLR cables SanDisk media iPhone 6 Final Cut Pro X iMac Tama mic stands Rotations is part of the Media in Medicine family of medical storytelling and is copyrighted. Rotations is made possible by the generous understanding and accommodation of our beloved institution, Ohio University and by the Ohio University Heritage College of Osteopathic Medicine and Scripps College of Communications. The comments and ideas expressed on Rotations are that of the content creators alone and may not reflect official policy or the opinion of any agency of the Ohio University.

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli. Become a patron of TWiM. Links: Please take the TWiM listener survey Bacteria help dengue virus in mosquito gut (Cell Host Micr) Fungus helps dengue virus in mosquito gut (TWiV 479) Minicells for disposal of damaged goods (mSphere) TWiM Listener survey Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Send your microbiology questions and comments to twim@microbe.tv

The TWiP Wataalamu solve the case of the One Year Old From Kenya With Moving Skin Lesions, and describe how to make mosquitoes refractory to Plasmodium with engineered symbiotic bacteria. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Engineered Serratia make mosquitoes refractory to Plasmodium (Science) Operation Sea Spray (Wikipedia) Photo credit Letters read on TWiP 141 Case Study for TWiP 141 A 59 yo Spanish speaking female on Long Island originally from Guatemala. Goes to ER after returning from 10 day trip to visit friends and relatives in Guatemala and El Salvador with fever, cough, diffuse muscle aches, fatigue, chills. Respiratory pathogen panel done, positive for rhinovirus. Told that it's just a virus, go home. 5 days later returns with fever and chills, pain in upper belly, feels constipated. Admitted. No past med/surg, no allergies, no significant family history, no meds. Works cleaning houses. Travel: spends most time in and around big cities, lots of exposure to animals, ate all local fare; conch ceviche, fresh eggs, flattened chicken dish. Elevated white count left shifted, neutrophils increased, eosinophils cleared; cultured Salmonella from blood. IV antibiotics given, gets better, about to go out the hospital door, when results of stool O&P comes back from initial admission. Observed: Entamoeba coli; Endolimax nana; Blastocystis hominis. Released to home, 2 weeks later feels fine. Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Ziel der Arbeit war es, das Vorkommen Antibiotika-resistenter Keime in Fleisch zu erfassen, um das Risiko des Übergangs resistenter Keime von Fleisch auf den Menschen besser einschätzen zu können. Gleichzeitig sollte geprüft werden, inwieweit die quantitative Erfassung von Resistenzgenen hierzu einen Beitrag leisten kann. Hierzu wurden in dem Zeitraum von November 2003 bis Februar 2005 aus 500 „Hähnchen-" und 500 „Schweinefleisch-Proben“ Bakterien der Gattungen Escherichia (E. coli, n=677), Salmonella (n=89), Campylobacter (n=421), Listeria (n=417), Enterococcus (n=782), Enterobacter (n=167), Citrobacter (n=83), Serratia (n=116) und Klebsiella (n=125) isoliert. Die untersuchten Fleischproben stammten jeweils zu gleichen Teilen vom Schlachthof und von der Verkaufstheke. Die Prüfung der Isolate hinsichtlich ihres Empfindlichkeitsverhaltens erfolgte gegenüber bis zu 31 ausgewählten, größtenteils human-relevanten Antibiotika im Mikrodilutionsverfahren. Weitere 100 „Hähnchen-" und 100 „Schweinefleisch-Proben“ wurden mittels real-time PCR nach Direkt-Extraktion der DNA auf das quantitative Vorkommen der Tetrazyklin-Resistenzgene tet (M) und tet (O) untersucht. Die Analyse der Prävalenzzahlen ergab zum einen, dass aus den „Schweinefleisch-Proben“ weit weniger Isolate (ausgenommen coliformer Keime) als aus den „Hähnchenfleisch-Proben“ gewonnen werden konnten. Zum anderen war das Vorkommen von Listeria spp., aber auch von coliformen Keimen und Salmonella spp. bei den „Verkaufstheke-Proben“ deutlich höher als bei den entsprechenden „Schlachthof-Proben“; gegensätzlich dazu verhielten sich die Campylobacter-Prävalenzraten. Im Rahmen der phänotypischen Empfindlichkeitsuntersuchungen wurde das Vorkommen resistenter und hochmehrfach-resistenter Keime in zum Verzehr geeignetem Fleisch nachgewiesen. Hinsichtlich der verschiedenen Bakterienspezies wurden sehr große Differenzen beobachtet. So mussten 69,0 % der E. coli, 61,8 % der Salmonella spp., 67,1 % der C. jejuni, 76,9 % der C. coli, 74,1 % der E. faecalis, hingegen nur 4,7 % der L. monocytogenes und nur 6,2 % der L. innocua als zumindest einfach-resistent eingestuft werden. Hierbei trugen die untersuchten E. coli-Stämme vor allem Resistenzen gegen Penicilline, die Aminoglykoside Streptomycin und Spectinomycin sowie gegen die Antibiotika Doxyzyklin, Sulfamethoxazol+Trimethoprim. Bei Campylobacter spp. wurden Resistenzraten von bis zu 30 % gegenüber Enrofloxacin, Ciprofloxacin, Ampicillin und Doxyzyklin ermittelt; zudem war bei den C. coli-Stämmen ein hohes Resistenzvorkommen gegenüber Sulfamethoxazol+ Trimethoprim zu beobachten. Bei dem Genus Enterococcus traten vor allem gegen Makrolide und die Wirkstoffe Doxyzyklin, Rifampicin und Fosfomycin Resistenzen auf. Die Auftrennung der Ergebnisse entsprechend der Fleischarten ergab ein weit häufigeres Vorkommen von resistenten Keimen in Hähnchenfleisch als in Schweinefleisch. Diese Tendenz war auch bezüglich mehrfach-resistenter Keime zu beobachten. So waren z. B. bei E. coli 46,1 % der aus Schweinefleisch und 61,1 % der aus Hähnchenfleisch isolierten Stämme als mehrfach-resistent einzustufen; bei den E. faecalis-Isolaten 20,3 % bzw. 47,8 %. Des Weiteren wiesen die Proben von der Verkaufstheke tendenziell häufiger Keime mit Resistenzen auf als solche vom Schlachthof. Vergleicht man die erhobenen Resistenzraten mit denen des GENARS-Projektes, so lagen in der überwiegenden Mehrzahl der Fälle die Resistenzraten der „aviären“ und „porcinen“ Isolate deutlich unter denen „humaner“ Isolate. Bei den molekularbiologischen Untersuchungen wurden relativ geringe Konzentrationen von tet (M) und tet (O) auf Fleischoberflächen gefunden. So ist ein Übergang von resistenten Keimen von Fleisch auf den Menschen durchaus möglich. Allerdings dürfte diesem Weg der Verbreitung Antibiotika-resistenter Keime eine geringere Bedeutung zukommen als mitunter angenommen.

N-Acylhomoserinlactones (AHL) are signalling molecules in gram-negative bacteria, which regulate, in a cell density dependent way, important interactive functions. This phenomenon is known as quorum-sensing. This work characterised the microbial ecology of the autoinducer (AHL) producing bacteria Serratia liquefaciens MG1 and Pseudomonas putida IsoF in the rhizosphere of tomato plants. Gfp- and rfp-tagged strains of the AHL producing wiltypes S. liquefaciens MG1 and P. putida IsoF were compared with its AHL-negative mutants, which were unable to produce AHL. Two kinds of plants cultivating systems were used: a defined axenic system and a complex soil system. The characterisation of the root colonisation behaviour was performed using confocal laserscanning microscopy (CLSM) and cell counting of bacteria. Fluorescence in situ hybridisation (FISH) and terminal restrictions fragment length polymorphism (t-RFLP)-techniques were used to examinate shifts of the bacterial population in the rhizosphere on tomato plants. The effective in situ production and spreading of AHL on tomato roots was demonstrated with P. putida IsoF using an AHL-sensor strain P. putida F117 pKR-C12. AHL was produced in effective concentrations in the rhizosphere of tomato plants and influenced the bacterial rhizosphere population. However, the AHL-production had no influence on the colonization behaviour of the AHL-producing strains S. liquefaciens MG1 and P. putida IsoF.