Podcasts about LPI

This week, we're building out a dry-tent and chopping down the Tropaya tomatoes! This is where months of effort, stress, and pride can go straight down the drain. Drying and curing is (possibly) the most important time when it comes to producing a tomato that burns with a white ash, oil ring, and full flavor to the glass tip. The smell from the plant is very nice and has a sour candy element to it! I'm excited to get these over the LPI screens and static tech the tomato resin! Terps N Things AC Infinity 2x4 tentAC Infinity 4" inline fanCammy Cat Gardens - Tropaya tomato cut! Thank you for listening and please make sure you check out all of our social medias and subscribe to our YouTube and Patreon!https://www.instagram.com/terpenetherapypodcast/https://www.patreon.com/terpenetherapypodcasthttps://www.youtube.com/channel/UCIuE6pg63WB2dwZ--1SgTig/featuredDisclaimer: This is an educational Podcast with comedic attributes to educate and entertain the viewer about my Life. In this video, I walked around a few places and documented my experience, and gave each location a rating. In certain parts of the Podcast, My Visual Effects team used Green Screen and CGI (Computer Generated Imagery) to simulate smoke, for comedic effect and expression. There is no real smoke in this video, and every viewer of the Podcast knows this. This is not the main focus of the video, just as a comedic expression in this larger Podcast. My special effects team works hard to make everything realistic while leaving a hint of artistic expression, to make the smoke simulations noticeably fake. This Podcast has been endorsed as educational content to educate and teach the viewer. Thank YouSupport the show

LPI: 80 Persen Masyarakat Percaya Peran Gibran Mengoptimalkan Kinerja Presiden | Pemerintah Diminta Tangani PHK Massal di PT Sritex | Kelompok Masyarakat Sipil Buka Posko Korban Pertamax Oplosan, Sudah Ada 400 Laporan

Episode 235 :         Welcome to the next episode of Pi Perspectives. Today we welcome back Christina Duran as we bring the spot light to Missing and exploited children and sex trafficking investigations. Christina has had an amazing career and has a passion for helping sex trafficking victims. The discussion is geared towards how you can get involved in this type of work. Please welcome Christina Duran and your host, NY private investigator, Matt Spaier  Links:      Matt's email: MatthewS@Satellitepi.com   Linkedin: Matthew Spaier       www.investigators-toolbox.com   Chirstina on Linkedin: Christina L. Duran, LPI, CPCI Email: Christina@amatrixinvestigations.com 
 PI-Perspectives Youtube link:  https://www.youtube.com/channel/UCYB3MaUg8k5w3k7UuvT6s0g Sponsors:     https://piinstitute.com/ https://pi-perspectivesinsurance.com/ https://www.skopenow.com https://researchfpr.com/ FBI Tip Line https://tips.fbi.gov/home https://www.fbi.gov/contact-us/field-offices/newyork/about - (212) 384-1000 CALI Disaster fund https://www.cali-pi.org/content.aspx?page_id=22&club_id=49391&module_id=451953

I denne episode har jeg inviteret psykolog og compassionnørd Mie Kamille Dalsgård ind i podcasten til en snak om Compassion. Compassion handler om at kunne få øje på smerte i sig selv og i andre, og om en dedikation til at handle trods smerte og ubehag. Men hvorfor er det særlig relevant at tale om compassion når vi har med forstyrret spisning og spiseforstyrrelser at gøre, og hvad har spiseforstyrrelser til fælles med psykisk skadelige forhold, det er noget af det du kan få svar på i denne episode.Det kommer vi blandt andet ind på i episoden:Lighederne mellem psykisk skadelige relationer og forstyrret spisning/spiseforstyrrelserOm tilknytningsmønstre og overlevelsesstrategier og hvordan de blander sig i relationen til os selv og i relationen til andreSubmissive compassionDe følelsesregulerende systemerForskellen på at have bevidst og ubevidst "forstyrret" adfærdHvad compassion er og hvad compassion ikke er Hvordan vores adfærd altid er afhængig af vores forudsætningerCompassion-taburettenOm prmære og sekundære følelserOm at turde give plads til svære følelserHvordan både frygt og omstændigheder kan aktivere vores grundsorgSlotsmetaforenHvornår det er "slemt nok" til at få hjælpI episoden deler jeg en øvelse du kan bruge, til at være mere med de følelser du mærker. Øvelsen kan du hente lige her: https://nadjavienberg.us17.list-manage.com/subscribe?u=fc541b0d0db9b43861dda6f19&id=a3e2005527Et centralt fokus i behandlingen af spiseforstyrrelser er at stoppe kampen med sig selv og finde nye strategier til at håndtere udfordrende tanker og følelser på (1)Vores biologisk-sociale mål og motivationer er styret af følelser, og vores hjerne indeholder mindst tre overordnede systemer til regulering af følelser (de følelsesregulerende systemer) (2) Menneskers oplevelser i relation til tilknytning har en stor betydning for udvklingen af systemer til følelsesmæssig regulering, især for systemet til social beroligelse, som fungerer gennem endorfiner og oxytocin (3)Manglende tryghed og selvregulering kan gøre en person med spiseforstyrrelse ekstra afhængig af at blive bekræftet af andre for at have det godt (4).Utryg tilknytning i præpuberteten er en god prædiktor for spiseforstyrrelser (5). En person med traumatisk baggrund vil ofte have ringe grund til at stole på andre, de vil ofte afvise information, som er i modstrid med deres egne tanker og meninger (6).En utryg tilknytning vil ofte komme til udtryk ved en utryghed ved egne meninger og intuitive opfattelser (6).Spiseforstyrrelser bør i højere grad beskrives som reguleringsforstyrrelser (7).Mangel på indre tryghed og selvregulering kan bidrage til at en person med spiseforstyrrelse føler sig utilstrækkelig , mislykket og uden kontrol (7).Kilder:1: L. K. Hecht et al. (2021) "Kort & godt om spiseforstyrrelser" s. 512: P. Gilbert (2018) "Compassion fokuseret terapi" s. 633: P. Gilbert (2018) "Compassion fokuseret terapi" s. 754: F. Skåderud et al. (2020) "SULT - mentaliseringsbaserede tilgange til spiseforstyrrelser" s. 635: F. Skåderud et al. (2020) "SULT - mentaliseringsbaserede tilgange til spiseforstyrrelser" s. 236: F. Skåderud et al. (2020) "SULT - mentaliseringsbaserede tilgange til spiseforstyrrelser" s. 497: F. Skåderud et al. (2020) "SULT - mentaliseringsbaserede tilgange til spiseforstyrrelser" s. 58

The Banff Patellofemoral Instability Instrument 2.0 (BPII 2.0) is a disease-specific, quality of life patient-reported outcome measure (PROM) that is valid and reliable in patients with recurrent lateral patellofemoral instability (LPI). Quality of life encompasses the physical, emotional, and psychological aspects of patient functioning and recovery.   In conclusion, a statistically significant correlation was evident between the BPII 2.0 and the other PROMs. The BPII 2.0 does not explicitly measure kinesiophobia or pain catastrophizing; however, the significant statistical relationship of the TSK-11 and PCS to the BPII 2.0 suggests that this information is being captured and reflected.   Click here to read the article.

Preston Bryant is a graduate of SMU Cox School of Business with a B.A. in Economics, specializing in energy. In college, he established an oil and gas company in memory of his late father. Preston furthered his expertise in commodities recovery at the firm LPI, where he uncovered a groundbreaking critical materials processing method called Membrane Solvent Extraction. After obtaining exclusive licensing rights from the Department of Energy's Oak Ridge National Lab, he founded Momentum Technologies with the mission to revolutionize the way metals were recovered by challenging the conventional norms that processing facilities must be large, expensive, and centralized. ⁠https://momentum.technology⁠ ⁠https://nexuspmg.com/⁠

You can contact Women Talking About Learning through our website, womentalkingaboutlearning.com The recording room for 1st December is this link. We're on Twitter @WTAL_Podcast You can buy us a coffee to support Women Talking About Learning via Ko-Fi. Or you can email us via hello@llarn.com   Episode Links: Andy Murray corrects journalist for overlooking female players – video | An Paternity leave: The hidden barriers keeping men at work - BBC Worklife New EU Law on Pay Transparency We're at a gender equality crossroads: which path will the government take? The gender biases that shape our brains Gender Bias And How To Recognize And Navigate Warning Signs The Unconscious Bias Women Have Against Women Gender Equality and Educational Opportunities: Can Gender Shape Your Career? The Underpensioned: Defining the Gender Pension Gap International Equal Pay Day 18 September Gender bias in academia: a lifetime problem that needs solutions Gender Bias Faced By Girls and What We Can Do: £513bn increase in UK Gender Investment Gap in a year Invisible Women: Data Bias in a World Designed for Men The World is Designed for Men The deadly truth about a world built for men – from stab vests to car crashes Lean In Neural Correlates of Gender Differences in Reputation Building Tall poppy syndrome 75% Of Women Executives Experience Imposter Syndrome In The Workplace Tox Report 65. The toaster theory of sexual debasement Enough platitudes and excuses: here is the truth about this week of sexism The state of gender inequality in Latin America   This week's guests are Mariana Horrisberger is an English, Spanish and Portuguese translator with over 10 years of experience in the e-learning localisation field. Born and raised in Argentina, she has travelled and moved around plenty in her career. Over the last 5 years, she has specialised in high-profile learning programs in the Corporate Training and Higher Education localisation realms. She believes firmly in uplifting others, so she strives to give back and be a force of good in the L&D community. She is currently co-leading the Global Learning and Development Community, a networking space for people in Learning and Development.    links: https://linktr.ee/marianahorrisberger  https://www.linkedin.com/in/horrisbergermariana/  https://mygldc.com/   Yasmine Alani - Director of Transformation Yasmine is a multi-award winning professional, recognised for being a Top 100 Future Leader, Culture Pioneer of Learning, and The LPI's Learning Professional of the Year.  She has a wealth of experience driving transformational change programmes across global organisations, including The Times, DLG, Ministry of Justice, HSBC, Rolls Royce, ASOS, and talkSPORT.    She has a passion for putting people at the centre of transformation, and has achieved meaningful change in the Culture space, from working with our legal system to tackle unconscious bias in domestic abuse cases in courtrooms, to designing bespoke leadership sessions to challenge c-suite executives to commit to true allyship.    LINKS https://www.linkedin.com/in/yasmine-alani/  

What if the key to elevating your recruitment process is reevaluating how you assess and onboard new hires? In this episode, Susanna talks to Bobby Banerjee, a seasoned recruitment strategist to explore optimizing recruitment and onboarding strategies. They discuss how to balance thoroughness with efficiency in interviews and the value of role plays for on-the-spot candidate assessment.  Bobby advocates for a streamlined process, suggesting flexible interview stages and avoiding overly complex assessments that could deter top talent. They discuss the ideal timing for evaluating new hires and emphasize the importance of setting clear expectations and assessing competencies beyond immediate billings.  He also introduces his innovative assessment tool, designed to provide deeper insights into candidates' behaviors and potential, moving beyond traditional CV metrics. Tune in now and learn how to enhance your recruitment process! Must-Hear Insights and Key Moments Streamline Your Process: Bobby shares how to create a more efficient recruitment process by recommending flexible interview stages and avoiding overly complex assessments that can discourage top candidates. Role Play for Real Insights: He highlights the effectiveness of role plays during interviews to assess candidates' skills and responses on the spot. Timing for Evaluation: Bobby explains the importance of evaluating new hires over a six to nine-month period to get an accurate sense of their potential and fit. Beyond Billings: He emphasizes setting clear expectations and evaluating candidates' competencies beyond immediate billings to ensure long-term success. Innovative Assessment Tool: Bobby introduces his new tool designed to provide deeper insights into candidates' behaviors and potential, moving past traditional CV metrics. About Bobby Banerjee Bobby Banerjee is a respected Director of Learning known for his expertise in recruitment training and coaching. He has trained over 500 recruiters, from trainees to senior leaders in FTSE 250 companies.  Specializing in customized recruitment training for onboarding, performance coaching, and talent acquisition teams, Bobby leverages his background as a recruitment consultant to address the real-world challenges faced by salespeople.  He won the LPI's Innovation in Learning Award in 2020 for his role in the FurLearn initiative during COVID-19. His training programs are designed to help consultants achieve faster billing and greater confidence. Connect with Bobby Banerjee: ⁠Website⁠ ⁠LinkedIn⁠ ⁠Instagram⁠ ⁠Facebook⁠ Follow The Counter Offer: ⁠LinkedIn Host⁠ ⁠LinkedIn Podcast⁠ ⁠Instagram⁠ Tiktok Check out our sponsor: Soul Space Studio Step into a world where breath becomes your greatest ally, an ever-present guide that reminds you of your inherent ability to find calm amidst the day-to-day. Tap into your inner strength and create profound shifts in your physical, mental, and emotional well-being at work. Soul Space Studio workplace wellbeing workshops and programmes can help your teams: reduce stress levels, create thriving cultures, deepen connection, and expand creative flow. Check out - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.soulspace-studio.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ for more information USE CODE: COUNTEROFFER for 10% discount

What is the MOSAIC-NLP project around structured and unstructured EHR data? Why is structured data not really enough for drug safety studies? And to what degree is NLP speeding up access to data and research results? We will learn all that and more in this episode of Research in Action with Dr. Darren Toh, Professor at Harvard Medical School and Principal Investigator at Sentinel Operations Center. www.oracle.com/health www.oracle.com/life  www.sentinelinitiative.org -------------------------------------------------------- Episode Transcript: 00;00;00;00 - 00;00;26;14 What is the MOSAIC and LP project around structured and unstructured data? Why is structured data not really enough for drug safety studies? And to what degree is NLP speeding up access to data and research results? We'll find all that out and more on this episode of Research in Action. Hello and welcome to Research in Action, brought to you by Oracle Life Sciences.   00;00;26;14 - 00;00;50;14 I'm Mike Stiles. And today our guest is Dr. Darren Toh, professor at Harvard Medical School and principal investigator at Sentinel Operations Center. He's got a lot of expertise in Pharmacoepidemiology as well as comparative effectiveness research and real-world data. So, Darren, really glad to have you with us today. Thank you. My pleasure to be here. Well, tell us how you wound up where you are today.   00;00;50;14 - 00;01;26;22 What what attracted you in the beginning to public health? Good question. So I trained in pharmacy originally, and I got my Masters degree in Pharmaceutical Outcomes Research at a University of Chicago, Illinois, Chicago. And it's where I first learned about a field called Pharmacoepidemiology, which sort of very interesting to me because I like to solve problems with methods and data and pharmacoepidemiology.   00;01;26;22 - 00;02;00;29 It seems to be able to teach me how to do that. So I got into the program at the Harvard School of Public Health, and when I was finishing up, I was deciding between staying in academia and going somewhere and getting a real job. And that's when I found out about an opportunity within my current organization and I've heard great things about this organization.   00;02;00;29 - 00;02;29;26 So I thought I would give it a try. And the timing turned out to be perfect because when I joined, our group was responding to a request for proposal for what is called a mini sentinel pilot, which ultimately became the sentinel system that we have today. So I've been involved in the Sentinel system since the very beginning or before we began.   00;02;29;28 - 00;03;02;25 And for the past 15 years I've been with the system and the program and because I really like its public health mission and I'm also very drawn to the dedication of FDA, our partners and my colleagues to make this a successful program. Well, so now here you are, a principal investigator. What exactly is the Sentinel Operations Center? What's what's the mission there and what part do you specifically play in it?   00;03;02;27 - 00;03;52;26 Sentinel is a pretty unique system because it is a congressionally mandated system. So the Congress passed what is called the FDA Amendments Act in 2007. And within that FDA, the Congress asked FDA to create a new program to complement FDA existing systems to monitor medical product safety and more specifically, the Congress, US FDA, to create a post-market risk identification and analysis system that will be using data from multiple sources that will cover at least 1 million lives to to look at the safety of medical products after they are approved and marketed.   00;03;52;28 - 00;04;33;07 So in response to this congressional mandate, FDA launched what is called a Sentinel initiative in 2008 and in 2009 as I mentioned, FDA issued its request for proposal to launch the Mini Sentinel Pilot program, and the program grew into the sentinel system that we have today. So it's for my involvement. It sort of grew over time. So when I joined, as I mentioned, we were responding to this request for a proposal and we were very lucky to be awarded the contract.   00;04;33;09 - 00;05;04;05 So when it was starting, I serve as a one of the many epidemiologists on the team and I led several studies and I gradually took on more leadership responsibility and became the principal investigator of the Sentinel Operations Center in 2022. So I've been very fortunate to have a team of very professional and very dedicated colleagues within the operations center.   00;05;04;05 - 00;05;27;26 So on a day to day basis, we work with FDA to make sure that we can help them answer the questions they would like to get addressed. And we also work with our partners to make sure that they have the resources that they need to answer the questions for FDA. And most of the time I'm just the cheerleader in chief just to share my colleagues and our collaborators.   00;05;27;28 - 00;06;11;23 Now that's great. And and then specifically, there's the Mosaic NLP project that you're involved with. What is that trying to achieve and what are the collaborations being leveraged to get that done? So Sentinel Systems has always had access to medical claims data and electronic health record data or year data. One of the main goals for the current sentinel system is to incorporate even more data, both structured and unstructured, into the sentinel system and to combine it with advanced analytic methods so that FDA can answer even more regulatory questions.   00;06;11;25 - 00;06;40;09 So the Mosaic and NLP project was one of the projects that FDA funded to accomplish this goal. So the main goal of this project is to demonstrate how billing claims and data from multiple sources when combined with advanced machine learning and natural language processing methods, could be used to extract useful information from unstructured clinical data to perform a more robust drug safety assessment.   00;06;40;11 - 00;07;21;18 When we tried to launch this project, we decided that we would issue our own request for proposal. So there was an open and competitive process, and Oracle, together with their collaborators, were selected to lead this project. So I want to talk in broad or general terms right now about data sharing, the standards and practices around that. It kind of feels silly for anyone to say it's not needed, that we can get a comprehensive view and analysis of diseases and how they're impacting the population without it.   00;07;21;20 - 00;07;46;15 NIH is on board. It updated the DMS policy to promote data sharing. You know, the FDA obviously is leaning into this. So is data sharing now happening and advancing research as expected, or are there still hang ups? So I think we are making good progress. So I think the good news is data are just being accrued at an unprecedented rate.   00;07;46;17 - 00;08;28;21 So there are just so much data now for us to potentially access and analyze. There's always this concern about proper safeguard of individual privacy. And through our work, we also became very appreciative of other considerations, for example, the fishery responsibilities of the delivery systems and payers to protect patient data and make sure that they are used properly. So you mentioned the recent changes, including in data management, ensuring policy, which I think are moving us in the right direction.   00;08;28;26 - 00;08;56;23 But if you look closer at the NIH policy, it makes special considerations for proprietary data. So I would say that we have made some progress, but access to proprietary data remains very challenging. And the FDA, the NIH policy doesn't actually fully resolve that yet. When you think about the people who do make that argument for limited data sharing, they do mostly talk about what you just said about patient privacy.   00;08;56;23 - 00;09;25;20 IT proprietary data. Pharma is especially sensitive to that, I would imagine. So how do we incentivize the reluctant how can we ease their risks and concerns or can we? Yeah, it's a tough question. I think that this require a multi-pronged approach and I can only comment on some aspects of this. So I would say that at least based on our experience, the willingness or ability to share data often depends on the purpose.   00;09;25;23 - 00;09;55;29 That is, why do we need the data? Many data partners participate in Sentinel because of its public health mission, and our consideration is how would the data be used again, Is there proper safeguard of patient privacy and institutional interest? There are other ways to share data. For example, instead of asking the data to come to us, we can send analysis to where the data is.   00;09;56;06 - 00;10;34;22 And that is actually the principle follow by federated system like Sentinel. So we don't pull the data centrally. We send an analysis to the data partners and only get back what we need it. And it's usually in the summary level format. So that actually encourages more data sharing instead of less sharing. I would say that recent advances in some domains, such as tokenization and encryption, might also reduce some concern about a data sharing, a patient privacy concerns in academic settings.   00;10;34;29 - 00;11;24;26 We've been talking a lot about days, for example, for individual who collect the data and the people I propose to offer them authorship or proper acknowledgment if they are willing to share their data. But that is not sufficient in many cases outside of academic settings. If you look at what is happening in the past ten years or so, there are now a lot of what people call data aggregators that are able to bring together data from multiple delivery systems or health plans, and they seem to be able to develop a pretty effective model to convince the data provider to share that data in some way.   00;11;24;29 - 00;11;55;28 And a way to do that could be to help these data providers to manage their data more efficiently or to help them identify individuals who might be eligible for clinical trials. More quickly. So there are some incentives that we could think of to allow people to to share that data more openly but personally, I think that scientific data should be considered public good and hopefully that will become a reality one day.   00;11;56;00 - 00;12;23;21 Yeah, that's really interesting because it sounds like it's both a combination of centralized and decentralized tactics in terms of of data sharing and gathering. Why is it so important to use unstructured data in pharmacoepidemiology studies? And does NLP really make a huge difference in overcoming the limitations and extracting that data? So in the past, I think that that's true.   00;12;23;21 - 00;12;58;07 Now, many pharmaco epidemiologic studies rely on data. They are not collected for research purposes. So we use a lot of medical claims, data that are maintained by payers. We use each our data that are maintained by delivery systems. So this data are not created for research purposes and much of this data, at least for claim, is data stored in structured format using established coding systems like ICD ten.   00;12;58;10 - 00;13;39;06 Coding system and structured data sometimes are not granular enough for a given drug safety study and certain data or set of variables that are required for claims reimbursements or other business purposes might not be collected at all. And people felt that, well, maybe the information that we need could be extracted from unstructured data because as part of clinical care, the physicians or nurse practitioner or the health care provider might include that information in the notes, but use user data also pretty messy, especially that unstructured data.   00;13;39;08 - 00;14;05;25 So instead of going through the unstructured notes manually to extract this information manually, technique by natural language processing could help us do this task much more efficiently so that we can mind a larger model of unstructured data. Well, obviously, when it comes to real world evidence, you're a fan. Tell us what excites you about using it to complement clinical research.   00;14;05;25 - 00;14;42;07 Get us more evidence based insights and help practitioners make better decisions. Yeah, that's a great question. Yes, I'm a fan of so I personally don't quite like the dichotomy between conventional, randomized, controlled trial and real world data studies because they actually sit along a continuum. But is true that conventional randomized trials cannot address all the questions in clinical practice.   00;14;42;09 - 00;15;30;17 So that's where real data and real data studies come in, because real data like we discussed come from clinical practice. So they capture what happens in day to day clinical practice. So if we are thoughtful enough, we will be able to analyze the data properly and generate useful information to fill some of the knowledge gap. The truth is we have been using real data throughout the lifecycle of medical product development for many years now, ranging from understanding the natural history or burden of diseases to using real data as controls for single arm trials, and that we have been doing this before the term real data became popular.   00;15;30;19 - 00;15;57;11 So I see real data to complement what we could do in conventional randomized trials. So real data studies don't replace clinical trials. I see them to be complementary, and real data studies sometimes are the only way for us to get certain evidence. We already talked about Mosaic and LP that project, but I kind of want to go a little deeper with it.   00;15;57;11 - 00;16;42;02 The idea is to tackle the challenges of using link data structured and unstructured at scale. Tell us about a use case for that project and why it was chosen for this project. We actually, Cerner proposed to use the association between Montelukast, which is an asthma drug and neuropsychiatric events as a motivating example. It is also important to note that the project is not designed to answer this particular safety question, because if you look at the label of Montelukast, there's also already a box warning on neuropsychiatric events.   00;16;42;02 - 00;17;18;26 So FDA already has some knowledge about this being a potential adverse event associated with the medication. The reason why or recalls is has proposed this project was because we actually did look at this association in a previous sentinel study that only used structured data, although the study provided provided some very useful information. We also recognized that certain information that we needed was available in such a data, but may be available in unstructured data.   00;17;18;28 - 00;17;42;18 So if we are able to get more data from unstructured data, we might be able to understand this association better. So that's why this motivating example was chosen. Well, this is an Oracle podcast and Oracle is involved in Mosaic, so I think it's fair to ask you about the technology challenges that are involved in what you're trying to do.   00;17;42;19 - 00;18;17;24 What does the technology have to be able to do for you to experience success? So Mosaic in LP is I was at a very ambitious project because it is using an LP to extract multiple variables that are important for the study. That includes the study outcome, which when you look at it, is a composite of multiple clinical outcomes and it's also trying to extract important covariates that could help us reduce the bias associated with real data study.   00;18;17;26 - 00;19;01;24 So I think technology comes in well is powerful in many ways. First, thanks to technology, the project is able to access very large amount of data from millions of patients who seek care in more than 100 healthcare delivery systems across the country. So this was hard to imagine maybe ten or 15 years ago. But now we have access to lots and lots of data at our fingertips because of advances in technology, because of the large amount and the complexity of the data methods side and LP becomes even more important.   00;19;01;26 - 00;19;33;19 And for this project, we are also particularly interested in whether an LP algorithm developed in one year trial system could be applied to another system, which has been a challenge in our field because each year our system is created very differently. So one, an algorithm that works in one system might not work in another. So we are hoping that through advanced methods and technology, we will be able to address this problem.   00;19;33;21 - 00;19;57;15 So without this technology advances, we might not be able to do this study as efficiently as we could all So the task might might not be possible. So where are we going with this? I mean, let's say the project is a success. What will that mean in terms of the FDA's goals and how NLP gets applied in medical therapeutics safety surveillance?   00;19;57;18 - 00;20;38;03 The hope is that Sentinel system can answer even more questions than it can address today. And the way that we are trying to accomplish that is to see whether or how this complex, unstructured data, we combine it with advanced analytic methods can help us answer questions that could not be addressed by structured data alone. I think through this project we also learned a lot about how the challenges associated with analyzing a very large amount of data from multiple sources.   00;20;38;06 - 00;21;11;14 Again, service data is compiled from more than 100 systems, so it is big but also very complex. And in many of our studies we really need that large amount of data just to be able to answer the question because we may be focusing on rare exposures or real come. So you really need to start with very large from our data just to get to maybe the ten patients that are taking a medication.   00;21;11;17 - 00;21;44;15 And what you learn with Mosaic, can that get applied to addressing other public health issues like disparate ease and asthma diagnosis and treatment, especially when you think about diverse groups? Yeah, that's a great question. So is the project is not designed to address these important questions, but if we are able to better understand the completeness of social drivers of health in these data sources, then we will be able to leverage this data to answer these questions in the future.   00;21;44;18 - 00;22;04;26 I think about how a project like this gets a evaluated at various steps along the way. I guess that's my question. How I mean, what what methods are used to ensure the validity of real world evidence? So the good news is in the past few decades we have been using real data, even though we might not be using the term.   00;22;04;28 - 00;22;36;22 So there's been a lot of progress in the field to improve the validity of Real-World Data studies. So we now have a pretty good framework to identify fit for purpose data, and we also have very good understanding of appropriate design and analytic methods. So to target trial emulation and propensity score methods. So this project and many other projects in Sentinel are following this principle.   00;22;36;24 - 00;23;14;03 And one thing to also note that this project is also following the overall sentinel principle in transparency. So everything we do will be in the public domain to allow people to reproduce, so replicate the analysis. So the protocol is available in public domain, and when we are done with the study, everything will be made publicly available. So that's one way to make sure that the the work at least is reproducible or replicable.   00;23;14;05 - 00;23;43;00 And through that process, we hope to be able to improve the validity of this study. And what about comparisons? How do you compare the results from different data sources like claims data, structured data? You know, I extracted unstructured data, all of that. How was that done, the comparisons? So if you're talking about the Mosaic and LP study, so we have a pretty structured approach to address that question.   00;23;43;02 - 00;24;13;14 So we are using this proven principle of changing one thing and keeping everything else fixed to see what happens. So the project will start by using only claims data to replicate the previously done Sentinel study. And then we are going to add on such data to see whether the results are different. And then we add on an LP extract that unstructured data one at a time to see whether the results change.   00;24;13;21 - 00;24;40;24 So by fixing everything else to be constant and changing one thing, we'll be able to assess the added value of each how data, both structure and structure. And that's how we are going to do it within the Mosaic and LP study. And then what about scalability? How would you make sure the NLP models that you develop are scalable and transportable across all these different health systems of which there are many?   00;24;40;27 - 00;25;10;10 Yeah. The question again is about transport ability. So one thing that is unique about this study, as we briefly discussed earlier, was that the the survey yesterday to actually come from multiple healthcare systems. So the end up models that we are developing will be trained in tune on a sample of patients from this system and not from a single hospital network.   00;25;10;10 - 00;25;42;18 So at the development phase, we are already taking into account the potential diversity of different delivery system. And as part of this project, we also include another delivery system to apply and test the method as part of the transport ability assessment. So we are doing that to make sure that the LPI models that we are developing for this project will be useful for other system as well.   00;25;42;20 - 00;26;12;29 Unknown There is a larger question about computational resources, so that will be the issue that would still need to be addressed because a train and tuning this and NLP models within such a huge amount of data requires a lot of computing resources. So that is something that we could only partially address in our study. But if we want to apply or do the same thing in our system, that would be something to consider.   00;26;13;02 - 00;26;43;13 We talked a little bit about the collaboration with your tech partner, but these things usually have so many stakeholders and disciplines and silos. Tell us first why collaboration is a good thing and unavoidable anyway, and then what the challenges of collaboration are. Maybe some tips on how to best make them work. The problems that we face, at least many of the problems that I face quite complex and they require expertise from multiple domains.   00;26;43;13 - 00;27;18;19 So that calls for collaboration from multiple stakeholders. And we always have our blind spots. So we only see things in a certain way and we always miss things. So that's why I think collaboration is important. But it's really hard sometimes because we all have our priorities and perspectives and sometimes they don't align. And I also learned throughout the years that we don't communicate enough and we may also not have time to communicate or we may be under pressure to deliver.   00;27;18;21 - 00;27;47;21 So all of that sort of contribute to the challenges of collaborating effectively, especially when you collaborate across disciplines, because we might be using different languages to mean the same thing or use the same term to describe different things. So even though we can all speak the same language less English, we might not be talking about the same thing and not communicate at all.   00;27;47;21 - 00;28;17;25 Because because we are using different joggers and terminology. So that has been tough. But I think we are getting better. And so I think that it is for us within the center of operation center, we try to communicate honestly and respectfully and we try to understand different perspectives and we try to find common ground. And but I think ultimately what brings us together is that we have a shared common goal.   00;28;17;27 - 00;28;44;17 A lot of the work that we do. So for music and NLP, we are all trying to answer the same question, which is that how do we use unstructured data and advanced analytic methods to answer safety question? So once we apply on this common goal, things become easier because we start to understand each other better or be able to communicate more effectively.   00;28;44;19 - 00;29;19;16 Just out of curiosity, what are the different stakeholders involved in Mosaic? Who falls on the roster? we have people from different disciplines, so we have experts in natural language processing and artificial intelligence. We have epidemiologists, both statisticians, clinicians, we experts in psychiatric conditions and respiratory disease. We have data scientists, we have engineers, we have project managers. So it's a very big group of individuals with different expertise in this project.   00;29;19;18 - 00;29;46;14 Well, you probably noticed Oracle's really thrown itself into and committed huge resources to health and life sciences. Things got really exciting with the acquisition of Cerner and Cerner and Visa. What's Oracle doing right and what do you think it should be doing to make itself even more valuable in health and life sciences? Well, this is a great but very difficult question, so I cannot comment too much what Oracle is doing or will be doing.   00;29;46;17 - 00;30;23;06 But I can say more generally that there have been a number of technology companies that have tried to foray into health or life sciences. I would say with mixed results. And one reason is that our health care system remains highly fragmented and complex, so it takes a lot of energy to break the status quo. So you probably know that we were one of the last countries in the world to transition from ICD nine to ICD ten coding system, and we are soon going to move into the ICD 11 system.   00;30;23;06 - 00;31;00;05 So I'll be interested to see whether the US is ready for that. And that again, is maybe a reflection of just how complex and fragmented our system is and disruptive innovation and I think are great, but they may or may not translate into successes when they applied to health care. That is not to say tempesta mistake. I'm actually pretty optimistic that the perspectives and solutions and ideas brought by technology companies could help us solve a lot of problems that we have today.   00;31;00;07 - 00;31;31;26 But I think that it will be good to engage people who will be struggling with these issues early on and to work together with them to develop solutions that are not just good on paper, but also feasible in practice. So at least in my very limited experience, we have seen some very cool technology that ended up not being useful for health care just because it's very hard to change what people have been doing.   00;31;31;28 - 00;31;56;09 So again, disruptive innovations are good, but sometimes it's just very hard to adopt, at least not quickly enough for for us to see meaningful changes. Yeah, that's really fascinating. It's, you know, it is disruptive innovation, but it's not always applicable to the to the goals you're pursuing. But it does feel like technology where that's concerned, the future is coming at us faster and faster.   00;31;56;11 - 00;32;32;21 So what are the technologies that are most interesting to you? Is it A.I. or what big advances in public health do you see coming? Maybe sooner than we thought. Yeah. Yeah. You know, I feel like you said some of this came too fast. Like, I wish I. And closer to retirement, I don't worry about this. But so even though I say disruptive innovation sometime might not work in health care, but I will say generative A.I. seems to be a recent exception.   00;32;32;24 - 00;33;10;14 So I would say that generative is definitely on the list of things that surprised me in a very nice way. I will also say that the continue fast accrual of better real data is also something that excites me and the continue recognition or increased recognition of the potential real data of. It's also something that I think is good to have for things that came sooner than I found it again, generative.   00;33;10;19 - 00;33;44;13 AI So if you ask me when, we'll be ready for generally. AI Last year or two years ago, I would say not yet, but now we in the era where everything seems possible. So I remain extremely optimistic about generative in some of these last language models that will help us analyze unstructured data even more efficiently. Well, therein it's deeply fascinating and exciting stuff.   00;33;44;14 - 00;34;10;27 Thanks again for letting me pester you with these questions. If our listeners want to learn more about Sentinel, Operation Center or Mosaic or you, what's the best way for them to do that? So Sentinel has a poverty website where we post everything that we do. So is Sentinel initiative dot org. So I am a member of the Department of Population Medicine at Harvard Medical School.   00;34;10;29 - 00;35;00;16 So our website's population is a thought, but these would be two places that would be very informative for audience. Who wants to know more? All right. We appreciate that. And to our listeners, go ahead and subscribe to the show. Feel free to listen to past episodes because they are free. There's a lot to learn here. And if you want to learn more about how Oracle can accelerate your own life sciences research, just go to Oracle dot com slash life dash sciences and we'll see you next time on Research in Action.

Surprise! We recorded an episode!We're a little rusty, but it's like riding a  bike.  You never forget.  On this episode we interview Doug Blair about the beginning of LPI and genomics.  We talk about a lot of different sires and influential Holstein breeders.

In this super juicy episode, Ash is joined by Sarah Hatton, Chief Learning Officer at The LPI, to discuss their recently released 2024 Learning Survey. Ash and Sarah discuss what's changing in L&D, the direction of travel of our industry, and what we need to do to stay future focused. Happy listening! LINKS: The LPI Learning Survey 2024 Sarah's LinkedIn Ash's LinkedIn 

The traditional paradigm is that when a patient presents with acute angle closure due to pupil block, a peripheral iridotomy (PI) must be performed immediately. But in reality, is this always the best approach? Is it safe to treat medically for a period of time before the PI? In which situations might a PI actually exacerbate the acute angle closure? Dr. Ike Ahmed joins the podcast.

Emily Mongold, Stanford University The impact of liquefaction on a regional scale is not well understood or modeled with traditional approaches. This paper presents a method to quantitatively assess liquefaction hazard and risk on a regional scale, accounting for uncertainties in soil properties, groundwater conditions, ground shaking parameters, and empirical liquefaction potential index (LPI) equations. The regional analysis is applied to a case study to calculate regional occurrence rates for the extent and severity of liquefaction and to quantify losses resulting from ground shaking and liquefaction damage to residential buildings. We present a regional-scale metric to quantify the extent and severity of liquefaction. A sensitivity analysis on epistemic uncertainty indicates that the two most important factors on output liquefaction maps are the empirical liquefaction equation, emphasizing the necessity of incorporating multiple equations in future regional studies, and the water table level, highlighting concerns around data availability and sea level rise. Furthermore, the disaggregation of seismic sources reveals that triggering earthquakes for various extents of liquefaction originate from multiple sources, though primarily nearby faults and large magnitude ruptures. This finding indicates the value of adopting regional probabilistic analysis in future studies to capture the diverse sources and spatial distribution of liquefaction.

In Part 1 of Inside Scoop with an Entrepreneur, Steven May and Stefanie Hoover chat about taking an idea from inception to success. Steven gets real about learning from mistakes and not surrounding yourself with "yes" people. Steven May founded LPI, an entirely new and then successful loss prevention concept, in the late nineties, and continues to innovate as a board member for the Integritus Group. Listen as Steven describes what keeps him coming back to solve solutions in retail.

Ever launch a workshop that no one attended or an e-learning module that nobody accessed? It's surprisingly common: and one reason is that we're not always great at marketing our L&D initiatives. In this week's episode of The Mind Tools L&D Podcast, Ross Dick and Owen Ferguson seek to reverse this outcome with the help of Ashley Sinclair from MAAS Marketing – the world's only (we think) marketing agency focusing specifically on L&D. We discuss: ·       Why L&D teams need a marketing strategy ·       What an effective marketing strategy looks like ·       How to measure the ROI of a marketing strategy   For more from Ashley, visit maas-marketing.co.uk Ashley's podcast is at maas-marketing.co.uk/podcast The Mind Tools reports that were mentioned are available at: mindtools.com/business/research Ashley also mentioned the LPI's ‘Workplace Learning Report' In ‘What I Learned this Week', Ross D discussed the BBC's new series on Shakespeare., He also the Netflix series ‘Big Vape: The Rise and Fall of Juul'. For more from us, including access to our back catalogue of podcasts, visit mindtools.com/business. There, you'll also find details of our award-winning performance support toolkit, our off-the-shelf e-learning, and our custom work.    Connect with our speakers    If you'd like to share your thoughts on this episode, connect with our speakers: ·       Ross Dickie ·       Owen Ferguson ·       Ashley Sinclair

In this week's issue:  Volume staging for uveal melanoma shows improved prognostication measures than current staging Longitudinal changes in the anterior segment may impact the iridocorneal angle in patients with prior LPI for angle closure Even mild visual impairment is associated with increased fall risk, as found in a Singapore epidemiological study A new homoplasmic variant in the ND5 gene was associated with a Leber hereditaryroptic neuropathy-like phenotype in a Slovenian three-generation family

What can horses and brain damage teach us about learning? Sarah Ratcliff is an award-winning Learning Consultant, Speaker, and Ambassador for Learning, with over twenty years experience in the industry. She is currently a spokesperson for the learning provider Cegos, and a regular chair for the Learning Technologies conference. In 2020, she earned the esteemed Learning Professional of the Year award from the LPI. She talks to John about how the experiences in her life that have formed her views about learner engagement, including her love of horses and a debilitating head injury. 00:00 - Start 02:52 - How did Sarah get into learning? 09:47 - How do horses inform her view of learning? 14:48 - Her car crash and recovery 23:57 - Learner engagement 26:47 - Are marketing techniques useful for learner engagement? 36:10 - The extended L&D toolkit of today 42:59 - End Follow Sarah Linkedin: linkedin.com/in/sarahratcliff Website (company): http://www.cegos.co.uk/ Email: sarah.ratcliff@cegos.co.uk Contact John Helmer X: @johnhelmer LinkedIn: https://www.linkedin.com/in/johnhelmer/ Website: https://learninghackpodcast.com/ Patreon: https://www.patreon.com/LearningHack

Join us as we welcome Wes Burns MPA, LPI, CFLEPE, a polygraph expert, to explore the practical uses of polygraphs in the aftermath of betrayal. Learn how a polygraph may be beneficial in helping individuals find the path to renewal after betrayal and for those Choosing to stay after infidelity and betrayal. To contact Wes or learn more about his distinguished service and experience in the professional forensic field, check out his website here. Thank you for tuning in to our podcast for couples healing from infidelity and betrayal. As certified coaches, we aim to provide support and guidance for those who decide to stay in their relationship. We offer valuable insights, empathy, and hope on the journey toward healing. Join us weekly for encouragement, skills, and expertise. Your hosts are Certified Relational Recovery Coaches specializing in Infidelity and Betrayal: Hali Roderick- TICC, PCC, APSATS CPC-Candidate, ERCEM Candidate Read Hali's Bio Book with Hali Stephanie Hamby- MCLC, APSATS CPC-Candidate, ERCEM Candidate Read Stephanie's Bio https://stephaniehambycoaching.youcanbook.me/ Contact us:  info.choosingtostay@gmail.com Choosing To Stay Webinar: Join Hali as she teaches this monthly free webinar for those Choosing To Stay after infidelity and betrayal. Help. Her. Heal. for Men - Hali Roderick helps men learn more about empathy, conflict resolution, and healthy communication. Participants will receive weekly exercises and worksheets to help them gain the skills to begin healing a broken relationship.  Empowerment After Betrayal for Men - Hali Roderick leads a betrayal trauma support group for men who have been betrayed where they can gain tools and resources to recover from betrayal trauma in a healthy way while being surrounded by a supportive community.  Healing Hearts Course - Stephanie Hamby leads This Couples Course that is a comprehensive program designed for early recovery and healing couples to learn and experience valuable insights together. It focuses on partner betrayal trauma and sexual integrity issues or addiction. The course provides practical education and tools to support healing for the partner and relationship repair.  More from Choose Recovery Services: Choose Healing - Betrayal Trauma support for women - This weekly support group is for women who have recently experienced betrayal and are needing help to cope with the symptoms of trauma such as depression, hypervigilance, anxiety, and lack of trust. Ask questions from our team of coaches at Choose Recovery Services who have been there with this accessible group that is free for the first 12 weeks.  Choose 90 for Men - Support group for men who are ready to take the first step towards recovery from compulsive behavior, infidelity, and/or betrayal. Participants will gain tools and an understanding to better manage emotions and assess behaviors.  Choose 180 for Men - This support group helps men gain emotional intelligence so they can better manage unwanted behaviors. Participants will connect with other men, better understand their emotions, work through shame, and build a deep respect for themselves.  Choose 360 for Men - Support group for men who have reached a sense of wholeness in their recovery and are looking to maintain their recovery through awareness, accountability, and comradery.  Road to Recovery - Free monthly webinar with Luke and Alana Gordon for couples navigating the relational aspects that come along the road to recovery.  Should I Stay or Should I Go? - Amie Woolsey teaches this free monthly coaching call for those stuck trying to decide whether to stay in their marriage.  Connect with Choose Recovery on Instagram

VP of LPI Memphis Ciara Neill gives an update on some of your favorite places in Memphis! LPI has developed some of Memphis' most popular places! From Overton Square to Broad Avenue, Ciara keeps you updated on all of the fun events happening at LPI properties! For video options, click one of link below! https://youtu.be/T1wvDi8oPlQ For more Ask Alan! The Podcast, click right here! https://cronelawfirmplc.com/resources/ask-alan/ LPI Memphis: http://lpimemphis.com/

Welcome to foHRsight – a podcast about making work better brought to you by future foHRward.Having spent the majority of her career working in mental health, Christine now runs StarlingBrook Leadership and is a leadership consultant and executive coach.We start by talking about our own practices to support our wellbeing including Christine's meditation practice and how we manage so many distractions particularly those that come through social media.Christine shares her philosophy on leadership development and the importance of having the curiosity to build self-awareness (including understanding where our belief system comes from) before building skills.Here is a link to the LPI 360 https://www.leadershipchallenge.com/solutions/lpi360.aspxAnd the Enneagramhttps://www.truity.com/test/enneagram-personality-testAnd you can learn more about Christine's work here - https://www.starlingbrook.com/ and her Instagram link is https://www.instagram.com/starlingbrook_leadership/?hl=en (which is well worth the follow!).You can get a copy of the book that she co-authored here - https://www.amazon.ca/Christine-Burych/e/B0BKJRP2DJ/ref=aufs_dp_mata_dsk.Quick reminderDon't forget to sign up for our weekly newsletter foHRsight at www.futurefoHRward.com/foHRsight.Follow us on LinkedIn:Mark - http://www.linkedin.com/in/markedgarhr/Naomi - www.linkedin.com/in/naomititlemancolla/future foHRward - www.linkedin.com/company/future-fohrward/And on InstagramAnd finally big shout out to our Producer Emily Milling at the Ultimate Creative for making us sounds great! Learn more here - https://emilymilling.com/foHRsight+ is a private digitally-powered community for forward thinking senior HR leaders committed to making work better. Sign up here to join us at our virtual Open House on March 7th and here to express interest in the next cohort!Support the show

Is marketing a human skill? It's a question that Han was inspired to answer after The LPI's latest Learning Live Networks event. And so she's done just that, by having a one-woman debate live on the podcast. (We know… arguing with herself on a podcast… we always knew she was weird

In Episode 84, The 966 speaks with Faisal Durrani, partner and head of Middle East research for the global real estate company Knight Frank. Mr. Durrani shares some of the highlights and key information from Knight Frank's recently-released 2023 report on real estate in Saudi Arabia, The Saudi Report 2023, a publication which touches on many subjects beyond real estate, including hotels and tourism, travel preferences for Saudis domestically, and so much more. Before the conversation, the hosts discuss the situation in Sudan and Saudi Arabia's role in assisting other nations in getting its civilians out of harms way in the country, how a Saudi company became ensnared in the politics of the Western US water crisis, and much more. 4:01 - Richard's one big thing is Saudi Arabia's assistance in getting civilians out of harms way in the war-torn country. Sudan is just across the Red Sea from Saudi Arabia, and both nations share a long border with that pivotal trade route, raising the stakes for the Kingdom as yet another nation in its neighborhood is threatened with instability. Sudan has a 530-mile (853 km) coastline bordering the Red Sea, and that waterway's maximum width is 190 miles. There are fears that the fighting could further fragment the country, worsen political turbulence and draw in neighboring states. Saudi Arabia received praise from U.S. President Joe Biden for its work and hospitality in rescuing civilians from harm's way. 12:04 - Lucien's one big thing is the water crisis in the American west, and how it has ensnared a Saudi company, Fondomonte, a subsidiary of Almarai, the Kingdom's largest big agricultural company. Saudi Arabia's own water conservation has lead Saudi Arabia to explore farming and agriculture opportunities abroad, both in wheat and other imports from places like Ukraine and in Africa, and in agricultural enterprises abroad, including in the United States. Fondomonte in Arizona farms alfalfa to feed cows for dairy products in the Kingdom. Fondomonte had permitting applications into the state for drilling the wells but those were denied ceremoniously by the state's attorney general, Kris Mayes, who used the opportunity to make an example of Saudi Arabia's farms in Arizona and the need for water to be used by locals. The permits were denied after Hays raised objections in early April to state agencies about discrepancies in application paperwork, including listing different landowners and conflicting information about whether the wells were new or replacements,” azcentral.com reports. Valued at $14.3 billion, the Almarai Company – which owns about 10,000 acres of farmland in Arizona under its subsidiary, Fondomonte – is one of the biggest players in the Middle East's dairy supply. The company also owns about 3,500 acres in agriculture-heavy Southern California, according to public land records, where they use Colorado River water to irrigate crops.26:28 - The 966 speaks with Faisal Durrani, partner and head of Middle East research for the global real estate company Knight Frank. Mr. Durrani shares some of the highlights and key information from Knight Frank's recently-released 2023 report on real estate in Saudi Arabia, The Saudi Report 2023, a publication which touches on many subjects beyond real estate, including hotels and tourism, travel preferences for Saudis domestically, and so much more. 1:12:07 - Yallah! 6 top storylines to get you up to speed on all things Saudi headed into the weekend. World Military Spending Rises to Record as Insecurity SwellsDefense expenditure increased by 3.7% in real terms to reach a record high of $2.24 trillion in 2022, the Stockholm International Peace Research Institute, SIPRI, said on Monday. About half the annual increase was due to Ukraine's ballooning military budget, according to data for the eastern European country that excludes foreign aid. Arms budgets are expanding across Europe in response to Russia's aggression at the same time as tensions in East Asia are prompting larger outlays in that part of the world. In another sign of how the world is sliding back into a situation last seen during the Cold War, military expenditure in central and western European countries exceeded the 1989 level for the first time.Saudi Arabia Advances 17 Ranks in World Bank's Logistics Performance IndexSaudi Arabia, which came in at 38, was ranked 55 in the 2018 report, and has seen its stock as a global logistics hub rise as it formulates plans for as many as 60 logistics hubs around the Kingdom, and contemplates wholesale upgrades of existing ports, as well as a number of greenfield facilities. Identical rankings to Saudi Arabia were achieved by India, Lithuania, Portugal and Turkey, also all ranked 38-equal, with identical overall LPI scores of 3.4. The rankings were topped by Singapore, with a score of 4.2, with Finland coming second, also on 4.2 and Denmark third, with 4.1Saudis constitute 82.2% of workforce in financial and insurance activitiesReflecting the success of localization efforts, Saudis constituted 82.2 percent of the number of workers in the financial and insurance sectors in 2022.  Saudi citizens who are working in financial and insurance activities reached 75,001, while foreigners totaled only 16,290 or 17.8 percent, bringing the total number of workers to 91,291 last year.  Male workers made up 93 percent of the workforce in financial and insurance activities – reaching 71,648 workers in 2022, while the number of females working in these activities hit 19,643, according to Al-Eqtisadiyah. Saudi Public Investment Fund ranks 5th with worth $620bnThe ranking of Saudi Arabia's Public Investment Fund (PIF) has improved from sixth to fifth place among the largest sovereign funds in the world for the first time, with assets valued at SR2.3 trillion ($620 billion). The fund's share of the world's sovereign wealth has increased to 6.2%, up from 5.9%, according to Arab News.Unemployment in Saudi Arabia Reaches Record Low with Women Driving the Change — Jadwa InvestmentThe unemployment rate in Saudi Arabia dropped to 8 percent at the end of 2022, down from 11 percent in 2021, with women driving that positive change, according to a recently-released report from Jadwa Investment, citing the General Authority for Statistics' (GaStat) latest labor market release.Female unemployment was down to 15.4 percent in 2022 versus 22.5 percent in the previous year.Saudi Arabia is building more hotels than UAE for the first timeAccording to a report in Hotelier Middle East, the UAE is no longer the regional leader when it comes to building hotels. "According to STR, Saudi Arabia has almost double the number of hotel rooms being built than the UAE. Saudi sits behind only China and the US globally in terms of the number of hotel rooms currently being built."

Preston Bryant is a graduate of SMU Cox School of Business with a B.A. in Economics, specializing in energy. In college, he established an oil and gas company in memory of his late father. Preston furthered his expertise in commodities recovery at the firm LPI, where he uncovered a groundbreaking critical materials processing method called Membrane Solvent Extraction. After obtaining exclusive licensing rights from the Department of Energy's Oak Ridge National Lab, he founded Momentum Technologies with the mission to revolutionize the way metals were recovered by challenging the conventional norms that processing facilities must be large, expensive, and centralized. https://momentum.technology https://nexuspmg.com/

The ARC Badger is a portable stick welder. Trail welders are becoming even more common these days, and Lone Pine Industries has a cool new system hitting the market. LPI has finally figured out how to make a small portable powerful stick welder for the trail by utilizing Lithium-ion batteries technology. Tyler and Jimmy like stick welders because it truly gives you an advantage for welding. Being able to carry various types of rods lets you be able to solve almost any problem you come across. You can weld steel, cast steel, and even aluminum. WE ARE GIVING AWAY A WINCH! All you have to do to enter is leave us a review on iTunes/Apple Podcasts! Once we reach 500 reviews, we will do the drawing from those 500 reviews! At 300, 350, 400, and 450 reviews, we will do giveaways for some fun swag packs as well! So get your reviews in! Congrats to PEDDY1111 for winning the 300th Review! Six String Trucker for winning the 350th! Martlovesgarlic for winning the 400th! And to Redrockethotpocket for winning the 450th swag pack? Who's going to win the 500th? CALL US AND LEAVE US A VOICEMAIL!!!! We want to hear from you even more!!! You can call and say whatever you like! Ask a question, leave feedback, correct some information about welding, say how much you hate your jeep, and wish you had a Toyota! We will air them all, live, on the podcast! +01-916-345-4744. If you have any negative feedback, you can call our negative feedback hotline, 408-800-5169. 4Wheel Underground has all the suspension parts you need to take your off-road rig from leaf springs to a performance suspension system. We just ordered our kits for Kermit and Samantha and are looking forward to getting them. The ordering process was quite simple and answering the questionnaire to ensure we got the correct and best fitting kits for our vehicles. If you want to level up your suspension game make sure to check out 4Wheel Underground. Episode 385 is brought to you by all of our peeps over at patreon.com and irate4x4! Make sure to stop by and see all of the great perks you get for supporting SnailTrail4x4! Discount Codes, Monthly Give-Aways, Gift Boxes, the SnailTrail4x4 Community, and the ST4x4 Treasure Hunt! Thank you to all of those that support us! We wouldn't be able to do it without you guys (and gals!)! March's giveaway is with Devos Lighting. Devos has created the fantastic area light, LightRanger. This area light can light up a diameter area of about 60 ft. Has a height adjustment to help get the light out of your eyes, and maybe our favorite as you know... It's USB-C rechargeable. One lucky winner will get one of these lights, but to do so you need to be signed up on irate4x4. Huge Thanks to Lawless Corey for donating to this month's giveaway. Witch was a grip load of items from Coast Lighting to Walter grinding consumables to some fun items from Shurtape. Congratulations to James VanAndle for winning this month's giveaway Listener Discount Codes: MORRFlate - snailtrail to get 10% off MORRFlate Multi Tire Inflation Deflation™ KitsIronman 4x4 - snailtrail20 to get 20% off of all Ironman 4x4 branded equipment!Sidetracked Offroad - snailtrail4x4 (lowercase) to get 15% off lights and recovery gearSpartan Rope - snailtrail4x4 to get 10% off sitewideShock Surplus - SNAILTRAIL4x4 to get $25 off any order!Mob Armor - SNAILTRAIL4X4 for 15% off Midroll Music by ComaStudio from Pixabay

After a long absence, I return with almost 2.5 hours of solo rambles on what I've been up to, playing the game of life, overcoming hardships, unplugging from the endless doom and gloom of the news cycle, the Constitutionalist to Libertarian to Anarchist pipeline, why I think American culture will long outlast American government, a quick recap for Art and War listeners on how I came to live in the US and much more! As per usual, I also dig into some listener questions on everything from the complicated history of liberty in the US, overcoming feelings of hopelessness and nihilism, some thoughts on Minarchism, the authoritarian element of the gun community that wants to disarm those it considers 'enemies', what live music I plan on seeing this year and plenty else! Thanks everyone for putting up with the radio silence, I hope you enjoy this slightly longer than usual ramble! Check out my substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter:⁠ https://theanarch.substack.com  ⁠ You can support what I do by grabbing some LPI. merch:⁠ https://spiritofresistance.com/collections/libertypunk⁠ Social Media:⁠ https://www.instagram.com/br.the.anarch/⁠⁠ https://twitter.com/BRhatesFeds⁠ 3D Printing Gats:⁠ https://ctrlpew.com/the-complete-getting-started-guide/  ⁠ ⁠https://www.enblocpress.com/guide/

Missed it live? Here's your chance to listen to Ash & Han talk to none other than Ed Monk (CEO, The LPI) and Serena Gonsalves-Fersch (Global Head of Talent & Academy, SoftwareONE).  In this session, these two industry heavy-weights discuss the value L&D offers to organisations, and L&D's role in employee attraction and retention. So grab a drink, sit back and settle in for 56 minutes of amazing discussion, laughs and light bulb moments. Stay up to date, and be the first to know about upcoming live recordings, follow us on LinkedIn: MAAS Marketing Ashley Sinclair Hannah Waddams

Finally back with a new show! Wasting no time jumping into non-controversial topics such as the North Carolina Power Substation attack, the forest defense actions to prevent the building of 'Cop City' in Atlanta, a hot take on the US-Russian prisoner exchange of WNBA player Britney Griner for International Russian Arms Dealer Viktor Bout, the state of Indiana changing it's 'Castle Doctrine' on self-defense to include using deadly force against trespassing Law Enforcement, the supposed upcoming Pistol Brace ban and why gun control will always exist as long as government does. I also give a little update on stepping in to Co-Host Art and War more often going forward and briefly explain Mitch moving on from the show before jumping into the listener Q&A. I get into everything from the worrying attempt to authorize actual robocops to use lethal force in San Francisco, the risk of 'Keeping up with the Joneses' in the gear circle jerk and failing to train with what we have, some thoughts on combating Winter Depression and much more! Indiana Amended Castle Doctrine: https://theweek.com/articles/474702/indiana-law-that-lets-citizens-shoot-cops Check out my substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

Today we are joined by Dr. Linda Darling-Hammond. Joining us on election day, there's frankly a lot of anxiety around the current state of our world…not just who will win the election but if those results will be accepted, a general cynicism about our future, and especially in the classroom, teachers are reporting extraordinary rates of burnout and nihilism.Dr. Darling-Hammond has done a ton of work to improve educational policy: both by supporting teachers and by changing systems in schools to support learners, she's advocated for higher standards of the profession and fighting back against authoritarian, behaviorist methods. Yet, given the state of the world today and all the things going on, how do we inspire hope and restore that humanity to professional development?In this podcast, we discuss:Where should we go next? We know that many schools are shifting to more rote practices. This was already happening through various “back to basics” movements, and is reemerging in force in the “learning loss” debate. This is further complicated by the politicization of teaching to new levels, between outcries about CRT, LGBTQIA+ rights, antiracism, etc. - even just using the term “progressive education” at all.How do we navigate those waters? What do we build professional development that address this in 2022? How can teachers and administrators build these practices?How can professional development be used to combat those who wish to discredit educator expertise and shift to hiring unlicensed teachers and/or gig-based workers? How can we ensure that we maintain a high standard for the profession?At a systemic level…what does this look like for school administrators? Attempts to do school reform at a national level seems to have always centered on national testing and teacher evaluations, and it's been a “back to basics” way of looking at education that goes to those non-supported-by-research practices.GuestDr. Linda Darling-Hammond, the Charles E. Docummun Professor of Education Emeritus at the Stanford Graduate School of Education. She founded the Stanford Center for Opportunity Policy in Education and served as the faculty sponsor of the Stanford Teacher Education Program, which she helped to redesign. She is the President and CEO of the Learning Policy Institute. Also, she's the former President of the American Educational Research Association. She's written over 25 books and 500 articles including The Right to Learn, Preparing Teachers for Deeper Learning, and The Flat World and Education. She was the leader of the education transition team for Barack Obama's 2008 presidential campaign and Joe Biden's 2020 presidential campaign. And, she began her career as a public school teacher and co-founded a preschool and public high school.*In the recording, it was incorrectly mentioned that Dr. Darling-Hammond is the former president of LPI, she is the current president. She led both Barack Obama's and Joe Biden's US Dept of Education transition teams.ResourcesDr. Linda Darling-Hammond at StanfordLearning Policy InstitutePreparing Teachers for Deeper Learning by Linda Darling-Hammond et. al.The Civil Rights Road to Deeper Learning by Kia Darling-Hammond & Linda Darling-Hammond Hosted on Acast. See acast.com/privacy for more information.

The World Wildlife Fund and the Zoological Society of London recently published the latest Living Planet Index, which is designed to measure how animal populations are changing through time.  The purpose is to provide an assessment of the health of ecosystems and the state of biodiversity. The LPI only looks at the population of vertebrates:  […]

Gary gets a foreshadowing reality check from one of his kids & reminisces on rummage sales. The fellas discuss the Stream Deck, LPI series super shooter, and the Devante Adams photographer fiasco. In photography news, Taco Bell Weddings, the potentially record breaking Steichen image, Eastman Kodak hiring, artist burning original artworks, Canon R6 Mark II, BBB photographer complaints in Texas, and Canon Precision Alignment. UK Bombardiers look out for Gary at the Societies of Photographers convention in March and USA Bombardiers get ready for Imaging USA in January. Links posted in the show notes.The Societies of PhotographersImaging USASave 50% on your first year with 17 Hats using the code "photobomb" at checkout just go to www.17hats.comCheck out Gary's YouTube channel HERE.Check out Booray's YouTube channel HERE.Join our Facebook Group, the Bombardiers Lounge

The Queen of England only dies once, so the wildly ‘inappropriate' celebrations continue! This episode; I talk shit about the Royals, explain the situation of their modern existence to non-subjects of the Crown, touch on the Queen's pedophile son Prince Andrew being protested against in the wake of her death and Brits being arrested for doing so due to their lack of actual free speech, the weird romanticizing some Americans have about the ‘special relationship' between the US and UK and I get into why a fond post about the Queen from a gun rights advocate rubbed me the wrong way seeing as she rules over a disarmed populace and protected her pedophile son from the consequences of his actions on Epstein island. I share some thoughts on the stagnation of the gun industry in contrast to the shooting community's rapid advances in quality. I also talk Ukraine, nuke posturing, the G7 pledging a forever war and the ‘whodunnit' of the Nordstream pipeline! I also answer listener questions, and talk everything from the fact that seeking other's validation is bullshit, some favorite Anarchists, tattoo stories and more! Research into the Sexual Habits of Quail on Cocaine, and other Taxpayer funded misadventures: https://blogs.scientificamerican.com/scicurious-brain/cocaine-and-the-sexual-habits-of-quail-or-why-does-nih-fund-what-it-does/ Read 'The Bolshevik Myth' here: https://theanarchistlibrary.org/library/alexander-berkman-the-bolshevik-myth-diary-1920-22#toc11 Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

https://youtu.be/VjMYAkUq98I [I apologize for the audio trouble with the podcast.  The audio demons were busy! - Rich] Host: Fraser Cain ( @fcain )Special Guest: The first suspected exoplanet was identified back in 1988, and was then confirmed in 1992. Since then, the rate at which detection/confirmations have been made has been increasing. And JWST has already directly imaged its first exoplanet! What data are we able to gather from here on Earth? What are we able to learn about these planets from the data collected? How does exoplanet geology compare with our own geology here on Earth? Let's find out as we welcome planetary geologist Dr. Paul Byrne ( @ThePlanetaryGuy / https://eps.wustl.edu/people/paul-byrne ) to the WSH.    Paul Byrne received his B.A. in geology, and Ph.D. in planetary geology, from Trinity College Dublin, Ireland. He was a MESSENGER postdoctoral fellow at the Earth and Planets Laboratory of the Carnegie Institution for Science in Washington, DC, and an LPI postdoctoral fellow at the Lunar and Planetary Institute in Houston, Texas. He is an Associate Professor of Earth and Planetary Sciences at Washington University in St. Louis; before coming to WashU, he was an assistant and then associate professor at North Carolina State University.   Paul's research focuses on comparative planetary geology—comparing and contrasting the surfaces and interiors of planetary bodies, including Earth, to understand geological phenomena at the systems level. Byrne's research projects span the solar system from Mercury to Pluto and, increasingly, to the study of extrasolar planets. He uses remotely sensed data, numerical and physical models, and fieldwork in analogue settings on Earth to understand why planets look the way they do. Regular Guests: Dr. Leah Jenks ( https://leahjenks.com/ / @leahgjenks ) Beth Johnson - SETI Institute ( @SETIInstitute & @planetarypan ) Dave Dickinson ( http://astroguyz.com/ & @Astroguyz ) This week's stories: - Stars stealing planets! - A new satellite annoyance? - James Webb overturning the Big Bang?? - Water worlds! - The hazards of uncontrolled reentry. - The laws of outer space.   We've added a new way to donate to 365 Days of Astronomy to support editing, hosting, and production costs.  Just visit: https://www.patreon.com/365DaysOfAstronomy and donate as much as you can! Share the podcast with your friends and send the Patreon link to them too!  Every bit helps! Thank you! ------------------------------------ Do go visit http://www.redbubble.com/people/CosmoQuestX/shop for cool Astronomy Cast and CosmoQuest t-shirts, coffee mugs and other awesomeness! http://cosmoquest.org/Donate This show is made possible through your donations.  Thank you! (Haven't donated? It's not too late! Just click!) ------------------------------------ The 365 Days of Astronomy Podcast is produced by the Planetary Science Institute. http://www.psi.edu Visit us on the web at 365DaysOfAstronomy.org or email us at info@365DaysOfAstronomy.org.

Videos: Gary Null – Speaks to U.N. on Earth Day (Part 1 & 2) Iain McGilchrist, ‘We Need to Act' Iain McGilchrist is a former Fellow of All Souls College, Oxford, an associate Fellow of Green Templeton College, Oxford, a Fellow of the Royal College of Psychiatrists, a Fellow of the Royal Society of Arts, a Consultant Emeritus of the Bethlem and Maudsley Hospital, London, a former research Fellow in Neuroimaging at Johns Hopkins University Medical School, Baltimore, and a former Fellow of the Institute of Advanced Studies in Stellenbosch. He now lives on the Isle of Skye, off the coast of North West Scotland, where he continues to write, and lectures worldwide.   California's “holy herb” Yerba Santa found to be an effective natural treatment for Alzheimer's   Salk Institute for Biological Studies, September 19, 2022 Alzheimer's disease is the most common form of dementia, and aging is its primary risk factor. Therefore, researchers continue to look for ways to counter the effects of aging on the brain. In a recent study, researchers from The Salk Institute for Biological Studies discovered a potential natural treatment for Alzheimer's in the form of a medicinal herb found in California. In their study published in the journal Redox Biology, they found that yerba santa (Eriodictyon californicum), a plant native to California, contains an active compound called sterubin that could be used to treat people with Alzheimer's. Yerba santa, which is the Spanish for “holy herb,” is highly regarded as a medicine for respiratory diseases, bruising, fever, headaches, infections, and pain. For the current study, the researchers first examined 400 plant extracts with known medicinal properties for their ability to prevent oxytosis – a type of cell death that occurs in Alzheimer's disease – in mouse hippocampal nerve cells. The researchers found that sterubin exhibited the greatest protective effect against inflammation and other triggers of brain cell death. In particular, sterubin strongly reduced inflammation in microglia, which are brain cells that provide support to nerve cells. In addition, the researchers found that sterubin can remove iron from cells, helping to prevent iron accumulation. Iron accumulation can result in a type of nerve cell damage that accompanies aging and occurs in neurodegenerative problems. “Not only did sterubin turn out to be much more active than the other flavonoids in Yerba santa in our assays, it appears as good as, if not better than, other flavonoids we have studied,” said Pamela Maher, the corresponding author of the study. Vitamin B may reduce risk of stroke Zhengzhou University (China)  September 23, 2022   Researchers have uncovered evidence that suggests vitamin B supplements could help to reduce the risk of stroke, according to a study published in the journal Neurology. Vitamin B supplements are said to be beneficial for many health issues, including stress, anxiety, depression, dementia, Alzheimer's disease and heart disease. However, according to Xu Yuming of Zhengzhou University in Zhengzhou, China, previous studies have conflicting findings regarding the use of vitamin B supplements and stroke or heart attack. In order to determine the role of vitamin B supplements in the risk of stroke, Prof. Yuming and colleagues analyzed 14 randomized clinical trials involving a total of 54,913 participants  All studies compared use of vitamin B supplements with a placebo, or a very low dosage of the vitamin. All participants were then followed for a period of 6 months. Results of the analysis revealed that the participants taking the vitamin B supplements had a 7% reduced risk of stroke, compared with those taking the placebo supplements or a low dosage of vitamin B. The researchers found that a supplemental form of folate (vitamin B9) – a vitamin frequently found in fortified cereals – actually reduced the effect of vitamin B on the risk of stroke Additionally, the study showed that vitamin B12 did not have any effect on the risk of stroke.   Ginger may protect the brain from MSG toxicity, says fascinating research University of Jeddah (Saudi Arabia), September 23, 2013  For thousands of years, ginger has been hailed as a superfood for its healing properties that aid every system of the body. The oils that ginger contains are antibacterial, antiviral and antifungal, and ginger has even been found to inhibit cancer growth. Now a study has actually proven that ginger can reverse the damage done by monosodium glutamate, or MSG, a known harmful excitotoxin. After injecting pure MSG into rats for 30 days, researchers found subsequent withdrawal caused adverse effects including significant epinephrine, norepinephine, dopamine and serotonin depletion. Low levels of these important neurotransmitters can be detrimental to health. Subsequent to injecting lab rats with MSG, researchers injected ginger root extract for 30 more days and were able to completely reverse the neurotransmitter depletion and brain damage that MSG caused. Not only that, but the positive effects of ginger were maintained even after scientists stopped administering it! A wealth of independent studies show that MSG should be avoided at all costs. Also popularly printed on food labels as hydrolyzed protein, torula or autolyzed yeast, soy or yeast extract and soy protein isolate among some 40 other names, scientists have found that consuming MSG even in low doses can cause blood glutamate levels to fluctuate abnormally high and then stay there. Anyone suffering from a disease or immunity issue that would contribute to a weakened blood-brain barrier is then much more susceptible to the chemical seeping into his or her brain and doing damage. Studies have effectively linked MSG consumption to several neurodegenerative diseases, such as Parkinson's and Alzheimer's. Men with anxiety are more likely to die of cancer, study says Cambridge University's Institute of Public Health, September 20, 2022 Men over 40 who are plagued with generalized anxiety disorder are more than twice as likely to die of cancer than are men who do not have the mental affliction, new research finds. But for women who suffer from severe anxiety, the research found no increased risk of cancer death. That finding, presented at the European College of Neuropsychopharmacology's Congress in Vienna, emerges from the largest study ever to explore a link between anxiety and cancer. It tracked 15,938 Britons over 40 for 15 years. Even after researchers took account of factors that boost the risk of cancer, including age, alcohol consumption, smoking and chronic diseases, men with a diagnosis of generalized anxiety disorder were 2.15 times as likely to die of cancer than were those with no such diagnosis. Generalized anxiety disorder – a condition marked by excessive, uncontrollable worry about many areas of life – affected women more commonly than it did men. Among women in the large cohort studied, 2.4 percent suffered from the disorder. Among men in the cohort, 1.8 percent did. Whatever the relationship, says the study's lead author, the new findings identify extremely anxious men as a population whose mental and physical health should be closely tracked. “Society may need to consider anxiety as a warning signal for poor health,” said study lead author Olivia Remes of Cambridge University's Institute of Public Health. “With this study, we show that anxiety is more than just a personality trait,” but rather, a disorder linked to real and serious health risks. Out of Over 400 Compounds Analyzed, Red Grapes and Blueberries Are Tops In Boosting Immunity – So Effective They Work As Well As Drugs Linus Pauling Institute at Oregon State University, September 18, 2022Pterostilbene, an antioxidant produced by plants has been shown to exhibit exceptional properties in fighting infections, cancer, hypertriglycerides, as well as the ability to reverse cognitive decline. It is believed that the compound also has anti-diabetic properties. In an analysis of 446 compounds for their the ability to boost the innate immune system in humans, researchers in the Linus Pauling Institute at Oregon State University discovered just two that stood out from the crowd. Red grapes and blueberies both have an exceptional ability to significantly impact immune function. In fact, pterostilbene works as well as some commercial drugs.

Both of these compounds, which are called stilbenoids, worked in synergy with vitamin D and had a significant impact in raising the expression of the human cathelicidin antimicrobial peptide, or CAMP gene, that is involved in immune function.The research was published in Molecular Nutrition and Food Research, in studies supported by the National Institutes of Health.

Almost a decade ago, researchers discovered that pterostilbene helps regulate blood sugar and might help fight type-2 diabetes. The finding adds to a growing list of reasons to eat colorful fruit, especially blueberries, which are rich in compounds known as antioxidants. These molecules battle cell and DNA damage involved in cancer, heart disease, diabetes and perhaps also brain degeneration. 

Pterostilbene works as well as the commercial drug ciprofibrate to lower the levels of fats (lipids) and triglycerides — but they worked even more accurately. They are so specific that side-effects are non-existent.”Out of a study of hundreds of compounds, just these two popped right out,” said Adrian Gombart, an LPI principal investigator and associate professor in the OSU College of Science. “Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It's a pretty interesting interaction.”This research is the first to show a clear synergy with vitamin D that increased CAMP expression by several times, scientists said.The CAMP gene itself is also the subject of much study, as it has been shown to play a key role in the “innate” immune system, or the body's first line of defense and ability to combat bacterial infection. The innate immune response is especially important as many antibiotics increasingly lose their effectiveness.

Grapes don't have to be fermented to contain this antioxidant. It's actually found in the skin of red grapes along with other nutrients, such as minerals manganese and potassium and vitamins K, C and B1.Stilbenoids are compounds produced by plants to fight infections, and in human biology appear to affect some of the signaling pathways that allow vitamin D to do its job, researchers said. It appears that combining these compounds with vitamin D has considerably more biological impact than any of them would separately. Fungus in humans identified for first time as key factor in Crohn's disease Case Western Reserve University, September 22, 2022 A Case Western Reserve University School of Medicine-led team of international researchers has for the first time identified a fungus as a key factor in the development of Crohn's disease. The researchers also linked a new bacterium to the previous bacteria associated with Crohn's. The groundbreaking findings, published in mBio, could lead to potential new treatments and ultimately, cures for the debilitating inflammatory bowel disease, which causes severe abdominal pain, diarrhea, weight loss, and fatigue. Mycology at Case Western Reserve and University Hospitals Cleveland Medical Center “Essentially, patients with Crohn's have abnormal immune responses to these bacteria, which inhabit the intestines of all people. While most researchers focus their investigations on these bacteria, few have examined the role of fungi, which are also present in everyone's intestines. Our study adds significant new information to understanding why some people develop Crohn's disease. Equally important, it can result in a new generation of treatments, including medications and probiotics, which hold the potential for making qualitative and quantitative differences in the lives of people suffering from Crohn's.” The researchers assessed the mycobiome and bacteriome of patients with Crohn's disease and their Crohn's-free first degree relatives in nine families in northern France and Belgium, and in Crohn's-free individuals from four families living in the same geographic area. Specifically, they analyzed fecal samples of 20 Crohn's and 28 Crohn's-free patients from nine families and of 21 Crohn's-free patients of four families. The researchers found strong fungal-bacterial interactions in those with Crohn's disease: two bacteria (Escherichia coli and Serratia marcescens) and one fungus (Candida tropicalis) moved in lock step. The presence of all three in the sick family members was significantly higher compared to their healthy relatives, suggesting that the bacteria and fungus interact in the intestines. Additionally, test-tube research by the Ghannoum-led team found that the three work together (with the E. coli cells fusing to the fungal cells and S. marcescens forming a bridge connecting the microbes) to produce a biofilm — a thin, slimy layer of microorganisms found in the body that adheres to, among other sites, a portion of the intestines — which can prompt inflammation that results in the symptoms of Crohn's disease. This is first time any fungus has been linked to Crohn's in humans; previously it was only found in mice with the disease. The study is also the first to include S. marcescens in the Crohn's-linked bacteriome. Additionally, the researchers found that the presence of beneficial bacteria was significantly lower in the Crohn's patients, corroborating previous research findings.

The first suspected exoplanet was identified back in 1988, and was then confirmed in 1992. Since then, the rate at which detection/confirmations have been made has been increasing. And JWST has already directly imaged its first exoplanet! What data are we able to gather from here on Earth? What are we able to learn about these planets from the data collected? How does exoplanet geology compare with our own geology here on Earth? Let's find out as we welcome planetary geologist Dr. Paul Byrne, to the WSH. Paul Byrne received his B.A. in geology, and Ph.D. in planetary geology, from Trinity College Dublin, Ireland. He was a MESSENGER postdoctoral fellow at the Earth and Planets Laboratory of the Carnegie Institution for Science in Washington, DC, and an LPI postdoctoral fellow at the Lunar and Planetary Institute in Houston, Texas. He is an Associate Professor of Earth and Planetary Sciences at Washington University in St. Louis; before coming to WashU, he was an assistant and then associate professor at North Carolina State University. Paul's research focuses on comparative planetary geology—comparing and contrasting the surfaces and interiors of planetary bodies, including Earth, to understand geological phenomena at the systems level. Byrne's research projects span the solar system from Mercury to Pluto and, increasingly, to the study of extrasolar planets. He uses remotely sensed data, numerical and physical models, and fieldwork in analogue settings on Earth to understand why planets look the way they do.  Be sure to follow Paul on Twitter! **************************************** The Weekly Space Hangout is a production of CosmoQuest. Want to support CosmoQuest? Here are some specific ways you can help: Subscribe FREE to our YouTube channel at https://www.youtube.com/c/cosmoquest Subscribe to our podcasts Astronomy Cast and Daily Space where ever you get your podcasts! Watch our streams over on Twitch at https://www.twitch.tv/cosmoquestx – follow and subscribe! Become a Patreon of CosmoQuest https://www.patreon.com/cosmoquestx Become a Patreon of Astronomy Cast https://www.patreon.com/astronomycast Buy stuff from our Redbubble https://www.redbubble.com/people/cosmoquestx Join our Discord server for CosmoQuest - https://discord.gg/X8rw4vv Join the Weekly Space Hangout Crew! - http://www.wshcrew.space/ Don't forget to like and subscribe! Plus we love being shared out to new people, so tweet, comment, review us... all the free things you can do to help bring science into people's lives.  

Something a little different this week! A few recordings fell through so stepping in with a new episode from our producer's show ‘The B.R Hates Feds Show', B.R sits down with Reaper 1.1 to discuss everything from small unit tactics, the evolving and re-emerging culture of the civilian rifleman, the idea of his 'skill tree' post, how ‘marketing' is an essential part of warfare, how the use of ‘Hobo signs' could save you and your loved ones major distress in an unrest/disaster scenario, talk sniper campaigns and what can be learned from them as well as the role of force multipliers in unconventional fighting forces and much more! Check out Reaper 1.1 on Instagram here: https://www.instagram.com/reaper1.1.actual/ Check out his Patreon here: https://www.patreon.com/Reapershide Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

Finally returning with a solo show, I chat shit about EVERYTHING. Starting with the Euro and EU slowly tumbling towards turmoil and why that's awesome, Fauci stepping down and going off to live a cushy life in the private sector with zero consequences, I tap into my old comic nerd side and get into why the conservative bitching about She-Hulk is boring and dumb, just like the ‘culture war', why it's imperative to get outdoors and make sure your kit isn't going to be the death of you, hiking on public trails with gear and rifles and why it's important to desensitize Americans to the idea of armed civilians, why the vast majority of ‘2A guys' aren't worth a damn and I go back to my roots and unapologetically chat about my utter contempt for Ethno-Nats, Fascists, casual racists and their pathetic outsourcing of responsibility for their own shitty lives to ‘the other'. I also answer a ton of listener questions! Everything from if being a Christian Anarchist is contradictory, some advice for a budding European gunsmith on moving to the states, my thoughts on finding likeminded people to train with, my biggest fear, my thoughts on GMO foods, if I'd rather buy a Hi-Point or vote, if mass gun confiscations would result in foreign intervention, how to get motivated to eat right, some advice on making the jump for a new career move and much more! Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

In this episode I'm joined by No More Adjectives to wade into the topic of Anarchy full bore. We get into our common sense definition of what ‘Anarchy' means to us and it's ancient Greek origins, what made him an Anarchist as well as his deep dives into theory and subsequent quasi-rejection of it in favor of putting Anarchism into practice via Mutual Aid with AnComs in his local area, looking to successful Anarchist communities today like the Zapatistas in Southern Mexico and Rojavans in North-Eastern Syria, we get into the differences between leaders and rulers, the tribalist nature of people, including Anarchists looking for ‘their tribe' and the bombshell revelation of how lawns are both dumb and worse, French. We also discuss community building for preppers and likeminded people and the importance of being a social animal over a hermit, ‘Unions of Egoists', why ‘ideology' and labels are a constraint and much more! Follow No More Adjectives on Instagram here: https://www.instagram.com/no_more_adjectives/ Check out his writing and other material here: https://linktr.ee/Nomoreadjectives Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

A short morning reminder or coaching mindset episode. I do coaching for sales reps and small business owners and I thought some of the stuff we cover in our coaching conversations may help a few other folks as well. TODAY: In business we should be tracking our KPI's - Key Performance Indicators! I submit we should change it up or we should all add a habit to track our LPI's - Life (or Living) Performance Indicators! === THANK YOU TO OUR SPONSORS: Granite Garage Floors of Chattanooga: https://granitegaragefloors.com/location/chattanooga Vascular Institute of Chattanooga: https://www.vascularinstituteofchattanooga.com/ MedicareMisty: https://medicaremisty.com/ The Barn Nursery: https://www.barnnursery.com/ Rent-My-Equipment: https://www.rentmyequipment.com/ Tasty Donuts: https://www.thetastydonuts.com/ Tasty Scoops and Sweets: https://www.tastyscoopsandsweets.com/ Please consider supporting the podast by becoming a Patron: https://www.patreon.com/duringthebreakpodcast This podcast is powered by ZenCast.fm

This episode I'm joined by Mike the Polymath of the EasyPeasy Podcast, to discuss everything green thumb under the black flag! We get into meeting at Chillderburg and the vibe of Little Amsterdam, the perhaps slightly off-target prepper goal of the well stocked nuclear bunker instead of a thriving garden and network of skilled individuals, Mike's interviewing of Pro-Choice protestors concerning their views on mandating the jab, being peaceful not harmless, making relationships at your local farmer's market, the profitability of permaculture from even a small garden, finding space to garden if you don't have property of your own, Food ‘Churches' and Clubs to get around FDA bullshit and creating mutualistic relationships with like minded people. We also get into growing feed for your livestock and 'function stacking' with your garden and the ‘Yin' to the ‘Yang' of the buildup of centralized governance versus the rise of people taking an active interest in decentralized lifestyles and living freely and what our advantages are against the state and much more! Be sure to check out Mike's podcast: EasyPeasy on all good platforms and give him a listen! Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

Joining me this episode is Finance & Maneuver! A former Marine now helping out Vets and otherwise with their financial futures, building community through his page out in Arizona, putting together gonzo ‘Heat' and ‘The Town' style photoshoots, getting out training and more! We discuss everything from his anti-bank, anti-authority tone to learning under local AZ shooting community icons and having a photoshoot interrupted by a police helicopter. All that and more! Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

In this episode, I get into what I've been up to in the busy weeks following Chillderburg, some behind the scenes on the guerrilla photo shoots I've been a part of with Finance and Maneuver in the city and our big mansion shoot with WarBear and the value I see in repping gun culture in an edgier, more entertaining way. I also answer your questions including where do I see gun culture going over the next 15 years, why ‘Outlaw gun culture' will be an absolute necessity and much more! Investigate Chillderburg at Chillderburg.com and be sure to subscribe to their newsletter if you're coming next year! Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

In this live episode from Chillderburg, I sit down with a bunch of first time campers in and around ‘Little Amsterdam' including ‘G00nicidal Tendencies' and ‘An Appeal to Liberty', to chat about their experiences from the annual Memorial Day weekend liberty gathering in Texas! We get into how people are enjoying their time at the event, the melting pot of liberty people from all sorts of backgrounds, interests and skillsets, the cross-pollination of skills, ideas and knowledge on display around the camp, talk building Anti-Tank rifles on the homestead, Canada's ‘Maple Fascism', living free wherever you are, I make it VERY clear I am done with British cuisine, the surprisingly incredible taste of a Fat Konkin burger, legal home defense gas, Swedish suicide pods, the gang whips out daily carry lights from Modlite, Cloud Defensive vs RECCE by fire, the feasibility of getting Alex Jones or Michael Malice out to Chillderburg, the not a cult meeting, the trial of Anthony Fauci and how we discovered he's actually a witch, we nail down what Mormon 'Soaking' is, I get cultured on ‘Donkey Shows' in Tijuana, Appeal to Liberty talks about his Shroom induced Ego Death experience while camping and much more! Follow An Appeal to Liberty on Instagram here: @an_appeal_to_liberty_2.0 Follow G00Nicidal Tendencies on Instagram here: https://www.instagram.com/g00nicidal.tendencies/?hl=en Investigate Chillderburg at Chillderburg.com and be sure to subscribe to their newsletter if you're coming next year! Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

Don't mind the first four minutes, the audio gets more crisp after that! In this episode, I give one last sales pitch on Chillderburg, two weeks out from the event, chat about UFO's and what the Pentagon officials are testifying that they know on the subject on Capitol Hill, make some comments on the NY shooter and his plagiarized, low effort manifesto and Biden's full send return to Somalia, two years on from Trump pulling boots off the ground. I also ramble about the weird reactionary thing going on and why I see the trend as a divide between optimists and pessimists and the instant gratification ‘solutions' being pursued, and chat about my weekend in the great South Western outdoors rucking and camping! I also answer listener questions concerning my thoughts on reincarnation, keeping cool in the desert rucking with Qore Ice Plates, what the best topic is to change someone's mind on the necessity of the state and much more! Check out the Chillderburg FAQ either as the following bonus episode, or the original video on YouTube, here: https://www.youtube.com/watch?v=gP9DY2y4yKQ Check out our sponsors! 'How I Embraced The Suck!' a Podcast about real, propaganda free stories and real experiences from military Veterans from Vietnam, through to the Global War on Terror: https://open.spotify.com/show/5TBkfwLV8DxgbAF5FPMGx4?si=2819d594dd694b75 'State Line Mineral' - Custom Radio Programming, Encryption Key Loading for Business Radio & Surplus and New Radio Sales: https://statelinemineral.com/two-way-radio/ Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

In this quick 36 minute FAQ, Jake and myself go over some common questions about Chillderburg Vier! Chillderburg is a Texan liberty community event happening at Muleshoe Bend, TX May 28-30th (Memorial Day weekend). Check it out if you can, community building is important! Chillderburg.com for camp spots, show tickets and to donate! Check out my new substack website, ‘The Anarch' here where you can read my full write up on Chillderburg III, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

The name Ishay Ribo has become synonymous with heart-rending melodies, sweet vocals, depth, vibe, holy rhythm, and soaring visions of Moshiach reflected in the shining eyes of Israeli concert-goers of every background, from the most chareidi to the most secular. But who is Yishai Ribo really? What is the source for his passion, the messages powering his gift? What does he hope to accomplish on his upcoming US tour? And to what does he attribute his phenomenal success?  In this heart-to-heart interview for the Meaningful People Podcast, R' Yaakov Klein sits down with Ishay to “talk to him, not about him” - delving into the inner world of this singular personality and exploring the incredible experience of gifting am Yisrael with “HaLev Sheli”, his expansive heart, and the melodies that echo within the depth of his sweet and humble soul.  To purchase tickets for the Lashuv Habayta tour visit: https://en.ishayribo.com/tour - - -  R' Yaakov Klein is the founder and director of LPI (the Lost Princess Initiative), an organization devoted to spreading the inner light of Torah with am Yisrael - drawing on the theological foundation presented in his most recent book, “The Story of Our Lives” a life-changing exploration of Rebbe Nachman's tale, "The Lost Princess". Purchase The Story of Our Lives: https://www.amazon.com/Story-Our-Lives-Quest-Tradition/dp/0578749440 Subscribe to our Podcast  Apple Podcasts: https://apple.co/2WALuE2  Spotify: https://spoti.fi/39bNGnO  Google Podcasts: https://bit.ly/MPPGooglePodcasts  Or wherever Podcasts are available!     Follow us on Instagram: https://instagram.com/meaningfulpeoplepodcast  Like us on Facebook: https://bit.ly/MPPonFB  Follow us on Twitter:https://twitter.com/MeaningfuPplPod     Editor: Yaakov Citron  Podcast created by: Meaningful Minute     For more info and upcoming news check out:  https://MeaningfulPeoplePodcast.com     #jew #jewish #podcast #frum #rabbi #frumpodcast #meaningfulpeople #torah #mitzvah #hashem #jewishmusic #jewishpodcast #israel #kumzitz #nachigordon #jewishpod

In this very special three hour, in person interview, I sit down with the one and only: Whiskey and Rebellion! We catch up on what he's been up to in his two year absence, his nomad travels across the States living the van life, our takes on the Roe V. Wade chaos, chat about the end times, laugh about ‘good cops', get into the Irish, we get into the sci-fi novel Whiskey is working and the Heinlein inspiration behind it and I get into my work writing both fiction and non-fiction and the long painful process of writing, how Whiskey and Rebellion impacted what I was doing with my life and stopped me joining the military, the imposter syndrome that comes with having so many people looking to you for advice and opinions, influencers who sell themselves as having all the answers before they've really worked on themselves, Whiskey sends his love to the old school crowd and all his old followers, why you should love freedom and life wholeheartedly and much more! You can find Whiskey on Twitter here: https://twitter.com/thefreedomcult Check out our sponsors! 'How I Embraced The Suck!' a Podcast about real, propaganda free stories and real experiences from military Veterans from Vietnam, through to the Global War on Terror: https://open.spotify.com/show/5TBkfwLV8DxgbAF5FPMGx4?si=2819d594dd694b75 'State Line Mineral' - Custom Radio Programming, Encryption Key Loading for Business Radio & Surplus and New Radio Sales: https://statelinemineral.com/two-way-radio/ Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

This episode, my eMilitia co-host, Guns and Guillotines drops by to shoot the shit on everything from Anarchy and Peace, to some history and sights to see in his home state of South Carolina, what we think of non-Ukrainians fighting in Ukraine, we talk about roadtrippin what the state of education would look like without government, talk guns and gear, answer listener questions together and much more! Check out our sponsors! 'How I Embraced The Suck!' a Podcast about real, propaganda free stories and real experiences from military Veterans from Vietnam, through to the Global War on Terror: https://open.spotify.com/show/5TBkfwLV8DxgbAF5FPMGx4?si=2819d594dd694b75 'State Line Mineral' - Custom Radio Programming, Encryption Key Loading for Business Radio & Surplus and New Radio Sales: https://statelinemineral.com/two-way-radio/ Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/

In this episode, I share my outlook on city life after growing up in the countryside my whole life before moving to the urban sprawl, why I think city dwellers are more easily ‘conquered', how that is inherited from being peasants living within King's walled cities and paying tribute and taxes to their ruler, why more rugged individualists come from rural areas and get into what myself and the lads learnt from our most recent woodland excursion. Check out our sponsors! 'How I Embraced The Suck!' a Podcast about real, propaganda free stories and real experiences from military Veterans from Vietnam, through to the Global War on Terror: https://open.spotify.com/show/5TBkfwLV8DxgbAF5FPMGx4?si=2819d594dd694b75 'State Line Mineral' - Custom Radio Programming, Encryption Key Loading for Business Radio & Surplus and New Radio Sales: https://statelinemineral.com/two-way-radio/ Check out my new substack website, ‘The Anarch' here, and be sure to subscribe to the free newsletter: https://theanarch.substack.com You can support what I do by grabbing some LPI. merch: https://spiritofresistance.com/collections/libertypunk Social Media: https://www.instagram.com/br.the.anarch/ https://twitter.com/BRhatesFeds 3D Printing Gats: https://ctrlpew.com/the-complete-getting-started-guide/ https://www.enblocpress.com/guide/