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4 episodes with biological studies
3 episodes with biological studies
4 episodes with biological studies
2 episodes with biological studies
2 episodes with biological studies
3 episodes with biological studies
2 episodes with biological studies
2 episodes with biological studies
2 episodes with biological studies
* Time for Change: Dr. Change Tan received her Ph.D. in Biochemistry from the University of Pennsylvania and an M.S. in Organic Chemistry from Nankai University in Tianjin, China, and she also studied as a postdoctoral fellow for the Department of Genetics at Harvard Medical School. Tan served as associate professor in the Division of Biological Studies at the University of Missouri before working as a founder and investigator at the Forest of Life Research and Education Center. Dr. Tan's interests include origin of life and biodiversity, the relationship of organisms, molecular biotechnology method development, reproduction and signal transduction. Tan has written nearly 30 refereed journal articles, including several for the “Answers Research Journal,” and is the co-author, along with Rob Stadler of an eye opening book “The Stairway to Life: An Origin-of-Life Reality Check”, in which the authors specify requirements for the spontaneous formation of life and evaluate the prospects for natural processes to satisfy these requirements. * Prokaryotes Can't Change: at least not into Eukaryotes! No matter how the evolutionists try to spin it!
* Time for Change: Dr. Change Tan received her Ph.D. in Biochemistry from the University of Pennsylvania and an M.S. in Organic Chemistry from Nankai University in Tianjin, China, and she also studied as a postdoctoral fellow for the Department of Genetics at Harvard Medical School. Tan served as associate professor in the Division of Biological Studies at the University of Missouri before working as a founder and investigator at the Forest of Life Research and Education Center. Dr. Tan's interests include origin of life and biodiversity, the relationship of organisms, molecular biotechnology method development, reproduction and signal transduction. Tan has written nearly 30 refereed journal articles, including several for the “Answers Research Journal,” and is the co-author, along with Rob Stadler of an eye opening book “The Stairway to Life: An Origin-of-Life Reality Check”, in which the authors specify requirements for the spontaneous formation of life and evaluate the prospects for natural processes to satisfy these requirements. * Prokaryotes Can't Change: at least not into Eukaryotes! No matter how the evolutionists try to spin it!
Dr. Satchin Panda is a renowned neuroscientist and professor at the Salk Institute for Biological Studies. He is best known for his groundbreaking research on circadian rhythms, time-restricted eating, and their impact on metabolism and overall health. His work has significantly influenced the fields of chronobiology and nutrition. Dr. Panda is also the author of The Circadian Code, where he shares practical strategies to optimize health by aligning daily routines with the body's internal clock.In our conversation we discuss:(00:00) – What happens in our bodies when our circadian rhythm is out of sync(06:16) – How to know if your circadian rhythm is out of sync(11:07) – What matters more: timing of sleep or how long is your sleep(15:47) – Consistency in your sleep schedule(18:37) – Importance of getting bright natural light(24:23) – Resetting circadian rhythm for a night shift worker(28:54) – Product recommendation(30:50) – Compensating for lost or poor sleep(34:31) – What are the worst common habits the generation is doing that harm the quality of sleep(40:45) – Eating late in relation to quality of sleep(42:59) – Supplements(48:15) – Prolonged fasting(51:05) – Time window for liquid intake(54:07) – Sipping(56:10) – Exercising in the morning vs in the afternoon(59:24) – Factors that may be overlooked in improving circadian rhythm(1:01:32) – Ideal circadian dayLearn more about Dr. Satchin Panda:https://www.salk.edu/scientist/satchidananda-panda/https://www.instagram.com/satchin.panda/?hl=enhttps://www.linkedin.com/in/satchin-panda-926ba369App: https://www.mycircadianclock.org/Book: https://www.amazon.com/Circadian-Code-Supercharge-Transform-Midnight/dp/163565243XWatch full episodes on: https://www.youtube.com/@seankimConnect on IG: https://instagram.com/heyseankim
* Time for Change: Dr. Change Tan received her Ph.D. in Biochemistry from the University of Pennsylvania and an M.S. in Organic Chemistry from Nankai University in Tianjin, China, and she also studied as a postdoctoral fellow for the Department of Genetics at Harvard Medical School. Tan served as associate professor in the Division of Biological Studies at the University of Missouri before working as a founder and investigator at the Forest of Life Research and Education Center. Dr. Tan's interests include origin of life and biodiversity, the relationship of organisms, molecular biotechnology method development, reproduction and signal transduction. Tan has written nearly 30 refereed journal articles, including several for the “Answers Research Journal,” and is the co-author, along with Rob Stadler of an eye opening book “The Stairway to Life: An Origin-of-Life Reality Check”, in which the authors specify requirements for the spontaneous formation of life and evaluate the prospects for natural processes to satisfy these requirements.* Prokaryotes Can't Change: at least not into Eukaryotes! No matter how the evolutionists try to spin it!
* Time for Change: Dr. Change Tan received her Ph.D. in Biochemistry from the University of Pennsylvania and an M.S. in Organic Chemistry from Nankai University in Tianjin, China, and she also studied as a postdoctoral fellow for the Department of Genetics at Harvard Medical School. Tan served as associate professor in the Division of Biological Studies at the University of Missouri before working as a founder and investigator at the Forest of Life Research and Education Center. Dr. Tan's interests include origin of life and biodiversity, the relationship of organisms, molecular biotechnology method development, reproduction and signal transduction. Tan has written nearly 30 refereed journal articles, including several for the “Answers Research Journal,” and is the co-author, along with Rob Stadler of an eye opening book “The Stairway to Life: An Origin-of-Life Reality Check”, in which the authors specify requirements for the spontaneous formation of life and evaluate the prospects for natural processes to satisfy these requirements.* Prokaryotes Can't Change: at least not into Eukaryotes! No matter how the evolutionists try to spin it!
Send us a textDr. Peter Ordentlich, Ph.D. is Chief Scientific Officer and Founder, Syndax Pharmaceuticals ( https://syndax.com/team/peter-ordentlich-ph-d/ ), a company with a mission to obtain regulatory approval and commercialize drugs that extend and improve the lives of cancer patients, by drawing on the newest scientific research and advances, collaborating with determined problem solvers, and identifying value in overlooked aspects of science.Dr. Ordentlich co-founded the Company in October 2005 and has served as Chief Scientific Officer since September 2016.Dr. Ordentlich previously served as Syndax's Chief Technical Officer, Vice President, Translational Medicine, Executive Director, Translational Science, and Director, Scientific Affairs and Strategic Alliances.Prior to founding the company, Dr. Ordentlich was a scientist at the Salk Institute for Biological Studies, a biological research non-profit organization. He also spent five years as a research scientist at X-Ceptor Therapeutics, Inc., a drug discovery company, which was acquired by Exelixis, Inc.Dr. Ordentlich received a B.A. in Biochemistry and a Ph.D. in Immunology from the University of Pennsylvania.#PeterOrdentlich #SyndaxPharmaceuticals #Oncology #Cancer #Menin #KMT2Ar #AcuteLeukemias #NPM1m #AcuteMyeloidLeukemia #Revuforj #Niktimvo #Axatilimab #Revumenib #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show
Professor Sara C. Mednick is a cognitive neuroscientist at the University of California, Irvine and author of The Hidden Power of the Downstate (Hachette Go!, pub date: April, 2022) and Take a Nap! Change Your Life. (Workman). She is passionate about understanding how the brain works through her research into sleep and the autonomic nervous system. Dr. Mednick's seven-bedroom sleep lab works literally around-the-clock to discover methods for boosting cognition by napping, stimulating the brain with electricity, sound and light, and pharmacology. Her lab also investigates how the menstrual cycle and aging affect the brain. Her science has been continuously federally funded (National Institute of Health, National Science Foundation, Department of Defense Office of Naval Research, DARPA).Dr. Mednick was awarded the Office Naval Research Young Investigator Award in 2015. Her research findings have been published in such leading scientific journals as Nature Neuroscience and The Proceedings from the National Academy of Science, and covered by all major media outlets. She received a BA from Bard College, Annandale-on-Hudson, NY, in Drama/Dance. After college, her experience working in the psychiatry department at Bellevue Hospital in New York, inspired her to study the brain and how to make humans smarter through better sleep. She received a PhD in Psychology from Harvard University, and then completed a postdoc at the Salk Institute for Biological Studies and UC San Diego. She resides in San Diego, CA. SHOWNOTES:
This episode is brought to you by Bon Charge and Momentous. We used to think circadian rhythm only applied to sleep. But emerging science has revealed a link between our circadian rhythm and metabolism, cognition, risk for chronic diseases, and many other crucial aspects of our health. Our biology was designed to live in sync with a natural light-dark cycle, but modern-day society has disrupted this natural balance. Today on The Dhru Purohit Show, we're revisiting one of our favorite episodes with Dr. Satchin Panda. Dr. Panda dives deep into his groundbreaking circadian biology research and shares how leveraging your circadian rhythm can dramatically improve your sleep, lower your risk of chronic disease, and improve your cognitive function. They also discuss how time-restricted eating, exercise, and light can be used to help program your circadian rhythm and why it's especially important for shift workers to take advantage of these tools. Dr. Panda is pioneering circadian biology research. He is a professor at the Salk Institute for Biological Studies, a Pew Biomedical Scholar, founder of the UC San Diego Center for Circadian Biology, and recipient of the Julie Martin Mid-Career Award in Aging Research. Dr. Panda has spoken at conferences around the world about his work on circadian rhythms and diabetes, including Diabetes UK, the American Diabetes Association, the Danish Diabetes Association, and the professional diabetes societies of Europe and Australia. In this episode, Dhru and Dr. Panda dive into: Why late-night eating is so detrimental to our health (2:15) Organ systems that have a circadian rhythm (8:24) Common ailments that could be related to circadian rhythm disturbances (14:11) Night-shift work and cancer risk (20:19) How poor sleep perpetuates bad food choices (27:00) What happens in the body when you rely on an alarm clock (44:01) Why you need to accumulate sleep debt for better sleep (51:25) Time-restricted eating and sleep (1:00:40) How to combat fragmented sleep (1:15:35) The best time to work out (1:55:50) The link between exercise and cancer (2:07:55) Positive changes for better sleep health on a global scale (2:17:20) Strategies for night-shift workers to combat circadian rhythm disruption 02:45:10) Dr. Panda's research in firefighters (2:48:46) Tips for optimizing your circadian rhythm (3:14:20) Where to follow and support Dr. Panda's work (3:27:50) Also mentioned in this episode: The Circadian Code: Lose Weight, Supercharge Your Energy, and Transform Your Health from Morning to Midnight The Circadian Diabetes Code: Discover the Right Time to Eat, Sleep, and Exercise to Prevent and Reverse Prediabetes and Diabetes Download the MyCircadianClock app Try This: 6 Crazy Facts About Sleep Try This: How Exercise Helps Fight Cancer For more on Dr. Satchin Panda, follow him on Twitter @SatchinPanda, Instagram @satchin.panda, or his Website. This episode is brought to you by Bon Charge and Momentous. Right now, BON CHARGE is offering my community 15% off; just go to boncharge.com/DHRU and use coupon code DHRU to save 15%. Optimize your energy and mental clarity with the Momentous Three: Protein, Omega-3s, and Creatine made by and used by the best. Go to livemomentous.com and enter promo code DHRU to get 20% off any order. Learn more about your ad choices. Visit megaphone.fm/adchoices
Today we have a very special episode. Visit California invited us out of our New York City studio and over to the West Coast for a food-focused road trip around San Diego and North County, including stops in Carlsbad and Oceanside. We start our journey at the source at the legendary Chino Farm, where three generations of Japanese American Chinos have been growing incredible produce used by chefs throughout California. Our next stop is a visit with Jeff Lozano, a brand ambassador at San Diego's Ballast Point Brewing, one of the foundational craft beer makers in a city famous for its great beer. The journey then heads up Interstate 5 to Carlsbad, where we catch up with Eric Bost, a prolific chef behind the newly opened Wildland and the soon-to-open tasting menu restaurant Lilo. To close, Aliza and Matt share many more discoveries from their road trip around Southern California.More places we visited: Rare Society, City Tacos, Tribute Pizza, Wayfarer Bread, Aisu Creamery, Little Fox Cups and Cones, Wrench & Rodent. You can visit the Salk Institute for Biological Studies by reserving a spot on a weekly docent-led tour. And some great hotels to keep in mind: Catamaran Resort Hotel and Spa and the Omni La Costa Resort & Spa.To donate to California wildfire relief, visit Restaurants Care. This very special episode of This Is TASTE is supported by Visit California. While this episode was recorded before the LA wildfires in January, all of the restaurants featured are open for business, and we can't think of a better time to pay California a visit for your own food-obsessed road trip. Dining out in LA is one way to help support the city, and these truly were some amazing places. Questions about visiting LA now?See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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There are more potential moves on a Go board than there are atoms in the universe; the game is universally considered to be one of the most complex played by humans. And, yet, an AI computer program can play it perfectly. What does that mean for humanity? Terry Sejnowski is the Frances Crick Chair at the Salk Institute for Biological Studies, a Distinguished Professor at the University of San Diego, and author of the book “ChatGPT and The Future of AI.” Ricky Mulvey caught up with Sejnowski for a conversation about: - How chatbots work. - Mapping large neural models. - What a self-aware parrot can teach us about human consciousness. Premium Motley Fool members can catch replays from this week's AI Summit here: https://www.fool.com/premium/4056/coverage/2025/01/15/ai-summit-replay To become a premium Motley Fool member, go to www.fool.com/signup Host: Ricky Mulvey Guest: Terrence Sejnowski Producer: Mary Long Engineer: Rick Engdahl Learn more about your ad choices. Visit megaphone.fm/adchoices
Artificial intelligence is rapidly transforming business, technology, and society. On this episode of CXO Talk, Dr. Terrence Sejnowski, a renowned computational neuroscientist, deep learning pioneer, and author of "ChatGPT and the Future of AI," discusses the implications of this technological revolution. He explores how AI is evolving, drawing parallels with the human brain, and explains why a robust data strategy is crucial for successful AI implementation. Dr. Sejnowski holds the Francis Crick Chair at the Salk Institute for Biological Studies and is a Distinguished Professor at UC San Diego. Dr. Sejnowski explains the importance of lifelong learning for employees and emphasizes AI's role in augmenting, not replacing, human capabilities. He also addresses critical topics such as explainability in AI decision-making, ethical considerations, and the potential impact of AI on the future of work. This discussion offers practical guidance for business and technology leaders navigating the complexities of AI integration and its implications for their organizations. Episode Participants Terrence J. Sejnowski is Francis Crick Chair at The Salk Institute for Biological Studies and Distinguished Professor at the University of California at San Diego. He has published over 500 scientific papers and 12 books, including ChatGPT and The Future of AI: The Deep Language Learning Revolution. He was instrumental in shaping the BRAIN Initiative that was announced by the White House in 2013, and he received the prestigious Gruber Prize in Neuroscience in 2022 and the Brain Prize in 2024. Sejnowski was also a pioneer in developing learning algorithms for neural networks in the 1980s, inventing the Boltzmann machine with Geoffrey Hinton; this was the first learning algorithm for multilayer neural networks and laid the foundation for deep learning. He is the President of the Neural Information Processing Systems (NeurIPS) Foundation, which organizes the largest AI conference, and he is a leader in the recent convergence between neuroscience and AI. Michael Krigsman is a globally recognized analyst, strategic advisor, and industry commentator known for his deep expertise in digital transformation, innovation, and leadership. He has presented at industry events worldwide and written extensively on the reasons for IT failures. His work has been referenced in the media over 1,000 times and in more than 50 books and journal articles; his commentary on technology trends and business strategy reaches a global audience. #AI #ArtificialIntelligence #FutureofWork #DeepLearning #CXO #DigitalTransformation #BusinessStrategy #TechnologyLeadership #ChatGPT #cxotalk
In this episode, my guest is Dr. Terry Sejnowski, Ph.D., professor of computational neurobiology at the Salk Institute for Biological Studies. He is world-renowned for exploring how our brain processes and stores information and, with that understanding, for developing tools that enable us to markedly improve our ability to learn all types of information and skills. We discuss how to learn most effectively in order to truly master a subject or skill. Dr. Sejnowski explains how to use AI tools to forage for new information, generate ideas, predict the future, and assist in analyzing health data and making health-related decisions. We also explore non-AI strategies to enhance learning and creativity, including how specific types of exercise can improve mitochondrial function and cognitive performance. Listeners will gain insights into how computational methods and AI are transforming our understanding of brain function, learning, and memory, as well as the emerging roles of these tools in addressing personal health and treating brain diseases such as Alzheimer's and Parkinson's. Access the full show notes for this episode at hubermanlab.com. Pre-order Andrew's new book, Protocols: protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman David Protein: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman Joovv: https://joovv.com/huberman Timestamps 00:00:00 Dr. Terry Sejnowski 00:02:32 Sponsors: BetterHelp & Helix Sleep 00:05:19 Brain Structure & Function, Algorithmic Level 00:11:49 Basal Ganglia; Learning & Value Function 00:15:23 Value Function, Reward & Punishment 00:19:14 Cognitive vs. Procedural Learning, Active Learning, AI 00:25:56 Learning & Brain Storage 00:30:08 Traveling Waves, Sleep Spindles, Memory 00:32:08 Sponsors: AG1 & David 00:34:57 Tool: Increase Sleep Spindles; Memory, Ambien; Prescription Drugs 00:42:02 Psilocybin, Brain Connectivity 00:45:58 Tool: ‘Learning How to Learn' Course 00:49:36 Learning, Generational Differences, Technology, Social Media 00:58:37 Sponsors: LMNT & Joovv 01:01:06 Draining Experiences, AI & Social Media 01:06:52 Vigor & Aging, Continued Learning, Tool: Exercise & Mitochondrial Function 01:12:17 Tool: Cognitive Velocity; Quick Stressors, Mitochondria 01:16:58 AI, Imagined Futures, Possibilities 01:27:14 AI & Mapping Potential Options, Schizophrenia 01:30:56 Schizophrenia, Ketamine, Depression 01:36:15 AI, “Idea Pump,” Analyzing Research 01:42:11 AI, Medicine & Diagnostic Tool; Predicting Outcomes 01:50:04 Parkinson's Disease; Cognitive Velocity & Variables; Amphetamines 01:59:49 Free Will; Large Language Model (LLM), Personalities & Learning 02:12:40 Tool: Idea Generation, Mind Wandering, Learning 02:18:18 Dreams, Unconscious, Types of Dreams 02:22:56 Future Projects, Brain & Self-Attention 02:31:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
When it comes to weight management and all-around good metabolic health, we most often think about what to eat. But my guest would say that it's also crucial to think about when to eat,Emily Manoogian is a chronobiologist and clinical researcher at the Salk Institute for Biological Studies. Today on the show, Emily shares how to create an optimal schedule for a healthy metabolism by aligning your eating schedule with your circadian rhythm. She explains when to start eating after waking, when to stop eating before bed, the importance of sticking to a set schedule, and what happens to your metabolism when you don't follow these timing guidelines. We also talk about how to best distribute your calorie intake throughout the day and how to eat to mitigate the metabolic problems that come with being a shift worker.Resources Related to the PodcastThe Salk InstituteMy Circadian Clock appAoM Podcast #1,016: Unlock Better Sleep and Health by Harnessing Your Circadian RhythmConnect with Emily ManoogianEmily on LinkedInEmily on X
As the longtime collaborator of the 2024 Nobel laureates John Hopfield and Geoffrey Hinton, Terrence Sejnowski is one of America's most distinguished AI scientists. In his new book, ChatGPT and the Future of AI: The Deep Language Revolution, Sejnowski addresses some of the central technical and philosophical issues of today's large language model AI revolution. And in this wide-ranging conversation, we talked about everything from the origins of human language to the existential question of whether our brains and smart machines are converging. Unlike other AI researchers, Terry Sejnowski is able to make the deep language revolution accessible to a mainstream audience. Strongly recommended. Terrence J. Sejnowski is Francis Crick Chair at The Salk Institute for Biological Studies and Distinguished Professor at the University of California at San Diego. He has published over 500 scientific papers and 12 books, including The Computational Brain with Patricia Churchland. He was instrumental in shaping the BRAIN Initiative that was announced by the White House in 2013, and he received the prestigious Gruber Prize in Neuroscience in 2022.Named as one of the "100 most connected men" by GQ magazine, Andrew Keen is amongst the world's best known broadcasters and commentators. In addition to presenting KEEN ON, he is the host of the long-running How To Fix Democracy show. He is also the author of four prescient books about digital technology: CULT OF THE AMATEUR, DIGITAL VERTIGO, THE INTERNET IS NOT THE ANSWER and HOW TO FIX THE FUTURE. Andrew lives in San Francisco, is married to Cassandra Knight, Google's VP of Litigation & Discovery, and has two grown children.Keen On is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit keenon.substack.com/subscribe
How should we go about understanding LLMs? Do these language models truly understand what they are saying? Or is it possible that what appears to be intelligence in LLMs may be a mirror that merely reflects the intelligence of the human observer? In this episode, Terry Sejnowski explores the history and future of AI and its profound implications for understanding the human mind. He explains AI's evolution from early logic-based systems to cutting-edge advancements like deep learning and large language models, including ChatGPT, emphasizing the need for clear operational definitions and a strong mathematical foundation to advance AI research. Sejnowski also highlights the parallels between scientific discovery and engineering, discussing practical applications of AI in areas such as language translation and weather prediction. Terry Sejnowski is the Francis Crick Chair at The Salk Institute for Biological Studies and a Distinguished Professor at the University of California, San Diego. He has published over 500 scientific papers and 12 books, including ChatGPT and The Future of AI: The Deep Language Revolution.
With huge heads on top of spindly stalks, how do sunflowers defy gravity to stay standing? That was a question sent to CrowdScience by listener Frank, whose curiosity was piqued by the towering sunflowers on his neighbour's deck. They stay up not only when the weather is fine, but, even more impressively, during strong winds. Could this feat of strength, flexibility and balance inspire the construction of tall buildings? It's a question that takes presenter Anand Jagatia to a sunflower festival in England, to see how the sunflower's long evolutionary lineage has honed its structure. And from tall flowers to tall buildings, we turn to structural engineers, asking how these concepts factor into the design of the world's tallest skyscrapers. Can ideas drawn from sunflowers or other natural structures help buildings withstand wind, or even storm surges?Contributors: Stuart Beare, partner and grower at Tulley's Farm Roland Ennos, Visiting Professor in Biological Studies, University of Hull Sigrid Adriaenssen, Professor of Civil and Environmental Engineering, Princeton University Koichi Takada, founder of Koichi Takada Architects Presenter: Anand Jagatia Producer: Tom Bonnett Editor: Cathy Edwards Production Co-ordinator: Ishmael Soriano Studio Manager: Bob Nettles(Image: Tall Sunflower blooming in a field, Melbourne, Victoria, Australia Credit: Naomi Rahim via Getty Images)
In this special student-hosted episode of the “Weinberg in the World” podcast, student host Seora Kim, a junior majoring in economics, interviews Keith Haan, the senior vice president at Roivant Sciences. Keith graduated with a major in Biological Studies. Keith shares his journey from studying biology and playing baseball at Northwestern University to working in a lab at the medical school, which influenced his career path. He discusses his research on B cell signaling and Epstein-Barr virus, and how his interest in biotechnology led him to the finance industry. Keith explains his transition from equity research to venture capital and portfolio management, highlighting the interdisciplinary nature of his career! https://www.linkedin.com/in/keith-haan-9886a069/ Transcript: Seora Kim: Welcome to the Weinberg in the World podcast where we bring stories of interdisciplinary thinking in today's complex world. My name is Seora Kim, and I am your student host of this special episode of the podcast. I am a junior majoring in economics and minoring in data science and global health studies. Today, I am excited to be speaking with Keith Haan, who is the senior vice president at Roivant Sciences. Thank you, Keith, for taking the time to speak with me today. Keith Haan: Thank you, Seora. I'm happy to be here. Seora Kim: Awesome. To start us off today, I'm wondering if you can tell us a little bit more about your time at Northwestern as an undergraduate. What did you study? What were the impactful experiences for you that led to your current career path? Keith Haan: I was an undergraduate major in biology sort of focusing on cell and molecular biology, but my experience at Northwestern was also shaped a lot by the fact that I played baseball for Northwestern. And as part of trying to figure out what to do for the summers, the athletic department does have reach out, and certainly when I was going there, had reach out to sort of help place students with internships that would be interesting. And I ended up working doing research in a lab at the medical school a couple of summers. And I think that really influenced sort of where I wanted to go, and I ended up going and getting my PhD at the grad school down at the medical school campus. Seora Kim: Awesome. That is amazing. Can I ask a little bit more about what kind of research you did at the medical school that helped you pivot? Keith Haan: Yeah, so I worked in a lab that had two focuses. One was on B cell signaling and one was on the cellular factors that allowed Epstein-Barr virus to enter cells. So the two were sort of related. Epstein-Barr virus encodes some proteins that sort of co-opt B cell signaling, and so part of the group focused on that. And then another group of which I was part of really studied the host cell proteins that were involved in mediating entry of the virus to the cell. Seora Kim: Amazing. That sounds super cool. And I was also wondering, were there any pivotal moments for your decisions that shaped your different parts of your journey in your career path? Because I know that you had several experiences before coming to Roivant Sciences. Keith Haan: Yeah, so I would say during grad school, viral entry was a hot topic and was actually very topical for HIV entry and HIV treatments. And so, because some of those newer drugs were being studied in the clinic at that point in time, it sort of got me interested in the biotechnology field in general. But I was also looking at the company and saying, "Hey, this is a company that I think I know well because I understand viral entry well. It's a publicly traded company. That is also interesting." And so, I think given the pace of where the biotech field, where it was going and looking at equities as a way to really be exposed to a lot of what the industry was doing, not just from a single company standpoint, but from an industry-wide standpoint, I got interested in biotech stocks. Which led me into the finance industry starting in equity research, and then moving on in my career to being a partner at a venture firm, and then portfolio manager at a hedge fund. Seora Kim: Awesome. That is super cool because I know that there's a lot of students at Northwestern interested in like economics or finance, but then also the bio side of things. So it's super cool to learn about your experience and how you combined biology as well as finance-related careers in your path and how you did biotech-related stocks equity research. So can you share a little bit more about what you think was the most attractive elements in each part of those roles, like was the more interesting parts in equity research or venture capital's portfolio management, so the students can understand what are differences between those jobs? Keith Haan: Sure. So I can start with the equity research first. It was my foray into finance, and that time was really sort of spent leveraging what I knew and what I had gained just in either biological insights and then translating that to how I thought value could be created from companies. And obviously, at that point in time, there was a pretty big backfill for me in learning the financial building models. I mean, that was something that I had not done at Northwestern. So that was a very good learning experience to be able to combine both as well as to learn how stocks move independent of what you might consider to be an intrinsic value. So that whole learning experience I thought was very valuable. And ultimately, I wanted to be able to, instead of being on the analytical side in equity research, I wanted to move on to being in a place where I could be deploying capital against those ideas. And where my initial interest was, it was sort of the earlier stage, probably earlier in the clinic or preclinical, which was more attuned to what I had learned in my background in my PhD, but also in the small company and the company formation. And so, I chose to go to a venture capital firm where I thought I could really build on the skills that I had already developed in equity research. Seora Kim: Definitely. So I think something that is really interesting is that you're focusing on biotech stocks or biology related financials. So can you share a little bit more about what is different between regular stocks or health tech stocks with biotech stocks? Keith Haan: I think one thing that is different about the biotech sector in general is it is something that is, first of all, highly volatile. There can be very large price swings depending on whether the results from a clinical trial allows a company to move forward to the next step of the clinical studies or to get approved. And when you are putting things in the human body, sometimes you get the results you are expecting and sometimes you don't. So there is a lot of volatility around just those stocks in general. And because of that, it is not something that a lot of funds will necessarily allocate a lot of time or people to, unless they have people that have deep experience doing it. So it is, as opposed to funds that may have a lot of their portfolio invested in tech or other industries that are a little bit better understood, healthcare is a little bit [inaudible 00:08:22], and biotech in particular is a little bit different. Seora Kim: Totally. That makes a lot of sense. And since you mentioned it requires a lot of knowledge and also because of the clinical trial stages, do you think that it's important for students who want to focus on biotech related finance roles to do bio majors or PhD? Or what kind of level of education would be required for these kind of roles? Keith Haan: I think it is helpful, but I have sat next to incredibly intelligent and very, very good people from all different backgrounds. So I have sat next to people that have finance or econ majors and have sort of picked up the biology, the clinical aspects, or the regulatory overlay over time. And then, there are many people that I've worked alongside that have a biology or have a medical background that sort of supplement and backfill with the financial overlay. Seora Kim: Definitely. So it's not necessary to have a bio background, but it can be a very diverse background and anyone who is interested can have a shot at this role? Keith Haan: Yeah, I mean, if you are sort of interested in that nexus, you can come into it from various backgrounds. Seora Kim: Perfect. That's amazing. That's great news for our students. And I guess going on with that, I wanted to learn a little bit more about your current company, Roivant Sciences. So can you maybe elaborate a little bit more on what are some of the current day-to-day in the job right now? Keith Haan: Sure. So in my role, I lead the group that is responsible for the licensing and acquisitions at Roivant. So Roivant is a little bit unique in that the licensing and acquisition plays a very large role in our strategy. So we look really industry-wide and where the innovation is, and a big part of where we find the innovation is external. And so, what we do is try to find collaborators and partner with those assets, and then found very nimble small companies that are really charged with bringing those forward in developing and commercializing them. Seora Kim: Well received. So regarding this kind of business model, would you say your investment strategy or how you find these smaller companies be based on certain criterias or standards? Keith Haan: Yeah, I mean, I think what we ultimately want to do is have something that we believe sort of meets our bar for having a reasonable likelihood of clinical and commercial success. And that can be we can get comfort with that in different ways. But in a lot of instances we can pull from maybe data sets for similar compounds or something has similar mechanism or maybe get comfort from extrapolating some early clinical data. Seora Kim: Sounds good. So regarding that, I think it's super cool to learn about how you bring these smaller companies to the market and commercialize them. Are there any significant trends or innovations currently that you are focused on, or what are some of the recent companies that you've brought on? Keith Haan: I think one of the things that is sort of part of the foundation of Roivant is being nimble and being able to go where the innovation is. So we don't constrain ourselves to looking in a particular therapeutic area or looking at a particular modality, whether it is small molecules or large molecules like antibodies or even other things like gene or cell therapy. What we are looking for is something that can truly be transformative for patients and therefore for Roivant. And the way we are set up, I think we are operationally set up to be able to go where the innovation is and where the field is going. Seora Kim: For sure. So it's super cool to learn how there's no restriction on which specific field that you guys are focused on, but just following the trend of innovation. So was wondering if you could maybe describe what are some of the more recent trend or innovations that you are seeing currently that is kind of the hot field in biotech world? Keith Haan: Yeah, so maybe I can use one of our recent sort of licensing deals to highlight some of those things. So we licensed a program from Pfizer in late in 2022. And part of what drew us to that asset was it had a unique biology where many drugs for inflammatory bowel disease or for inflammatory disorders in general can have the ability to really suppress the immune system. And we saw this asset as something that really had very strong efficacy, some of the strongest efficacy that had been shown in inflammatory bowel disease, but we also thought it maybe had a mechanism that wouldn't be associated with this immune suppression. So I think that was a very strong part of why we decided to bring that asset in. But another layer to that was we also had a biomarker which we felt could predict for even better responses. And I think that is something that really the field is trying to move toward is being able to really deliver the best outcomes for patients. And in inflammatory disorders, that is starting to, I think the field is trying to start to segregate patients who will respond to therapy better. That has been done in oncology, and so there is precedent there. But I think as we learn more about some of these diseases, there's something that certainly we are interested, but also the field is interested in as well. Seora Kim: Totally. That is amazing to learn about. And I think the inflammatory disorders is something that is super important to address, and it's really cool how Roivant Sciences is working towards patient improvement and patient experience. I think it's all leading to a much better world in the healthcare field. So thank you for sharing that example. And to close us out today, I have one last question for you. What do you wish you could tell yourself when you were in our shoes as college students? Keith Haan: Ah. Seora Kim: I'm sorry. Keith Haan: That's a good question. I think I guess what I would probably tell myself is what I would tell students at Northwestern or quite frankly the new employees that are coming into Roivant that are either fresh or relatively fresh out of undergrad is, one is be comfortable that your career is going to be, especially in this field, is going to be really based on sort of a lifetime of learning. It's a field that changes. And as you get more experience, you'll be able to develop expertise in those particular areas, but you will also be exposed to additional things that you might not necessarily have seen before. So just being comfortable with being in a field that is constantly changing and being comfortable with the fact that you just need to sort of be a bit of a lifelong learner. I think I would probably tell my younger self that, but it's something that is also important, and I would say to new employees coming in from undergrad as well. Seora Kim: Totally. That is super helpful for us to consider. Thank you so much for this great advice and for joining us today. Keith Haan: Thank you so much for having me. I appreciate it. Seora Kim: Thank you for listening to this special episode of the Weinberg in the World podcast. We hope you have a great day and go Cats!
Stat: 13%: The average five-year survival rate for pancreatic cancer patients in 2024, according to the American Cancer Society. This is compared to a 90% average five-year survival rate for people diagnosed with breast cancer. Story: Scientists have made tremendous progress on cancer research to improve patient survival rates. But challenges still exist because some cancers can suddenly become unaffected by treatment. In this episode, Christina Towers, a cancer cell biologist from the Salk Institute for Biological Studies, explains how cancer cells can adapt their metabolic processes—through a mechanism she studies called autophagy—to resist drug therapies. She discusses how her research studying this process could lead to new approaches to prevent and control a cancer's resistance to treatment—and, ultimately, save lives. And as the first Black faculty member at Salk, Towers shares how her mantra, “Honored to be first but refuse to be the last,” guides her efforts to increase diversity across the scientific community.
Sunlight has kept our brains on a 24-hour schedule for hundreds of thousands of years. Here's how. When sunlight touches your skin or hits your eyes, your brain ups the production of serotonin, to make you feel alert. And when night falls, your brain switches to releasing melatonin, so you know it's time to sleep. So when we don't get enough sunlight, our biological cycles can start to break. In this episode, we discuss: • How Vitamin D is made, and what benefits it has for your brain health • The evolutionary complexities of your circadian rhythm, and how it's been thrown into chaos by modern life • What happens to our mental health when winter shortens daylight hours • How light therapies can help people living in cloudier climates to protect their cognitive health • The association between not getting enough sunlight and developing neurodegenerative diseases like dementia We're joined by Population Health Science and Policy scientist and ‘lighting researcher' Dr. Mariana Figueiro to discuss how light-emulating technologies can help simulate sunlight in darker spaces during gloomier times of year. And Dr. Satchin Panda, leading expert in the field of circadian rhythm research and a founder of the Center for Circadian Biology at the University of California, to dive deep into the neurological intricacies of our 24-hour body clock. ‘Your Brain On' is hosted by neuroscientists and public health advocates Ayesha and Dean Sherzai. Drs. Ayesha and Dean are now welcoming patients via the Brain Health Institute: https://brainhealthinstitute.com/ ‘Your Brain On... Sunlight' • SEASON 2 • EPISODE 5 LINKS: Dr. Mariana Figueiro: at The Center for Health Design: https://www.healthdesign.org/experts/mariana-figueiro-phd TED Talk: https://www.tedmed.com/talks/show?id=293012 Dr. Satchin Panda: at the Salk Institute for Biological Studies: https://www.salk.edu/scientist/satchidananda-panda/ on Instagram: https://www.instagram.com/satchin.panda FOLLOW US Join the NEURO Academy: NEUROacademy.com Instagram: @thebraindocs Website: TheBrainDocs.com More info and episodes: TheBrainDocs.com/Podcast
BUFFALO, NY- April 9, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, “CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction.” Modulated by differences in genetic and environmental factors, laboratory mice often show progressive weight gain, eventually leading to obesity and metabolic dyshomeostasis. The geroneuroprotector CMS121 has a positive effect on energy metabolism in a mouse model of type 2 diabetes. In this new study, researchers Alcir L. Dafre, Saadia Zahid, Jessica Jorge Probst, Antonio Currais, Jingting Yu, David Schubert, and Pamela Maher from Salk Institute for Biological Studies, National University of Sciences and Technology (NUST) and Federal University of Santa Catarina investigated the potential of CMS121 to counteract the metabolic changes observed during the ageing process of wild type mice. “This comprehensive analysis aimed to further understand how CMS121 influences the metabolic landscape, paving the way for potential therapeutic applications beyond its established geroneuroprotective benefits.” Control or CMS121-containing diets were supplied ad libitum for 6 months, and mice were sacrificed at the age of 7 months. Blood, adipose tissue, and liver were analyzed for glucose, lipids, and protein markers of energy metabolism. The CMS121 diet induced a 40% decrease in body weight gain and improved both glucose and lipid indexes. Lower levels of hepatic caspase 1, caspase 3, and NOX4 were observed with CMS121 indicating a lower liver inflammatory status. Adipose tissue from CMS121-treated mice showed increased levels of the transcription factors Nrf1 and TFAM, as well as markers of mitochondrial electron transport complexes, levels of GLUT4 and a higher resting metabolic rate. Metabolomic analysis revealed elevated plasma concentrations of short chain acylcarnitines and butyrate metabolites in mice treated with CMS121. “The diminished de novo lipogenesis, which is associated with increased acetyl-CoA, acylcarnitine, and butyrate metabolite levels, could contribute to safeguarding not only the peripheral system but also the aging brain. By mimicking the effects of ketogenic diets, CMS121 holds promise for metabolic diseases such as obesity and diabetes, since these diets are hard to follow over the long term.” DOI - https://doi.org/10.18632/aging.205673 Corresponding authors - Pamela Maher - pmaher@salk.edu and Alcir L. Dafre - alcir.dafre@ufsc.br Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205673 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Join Dr. Sanya Virani and her guests, Alka Mathur, M.D., and Neal Amin, M.D., Ph.D. to discuss the invaluable new title The Psychiatry Resident Handbook which aims to provide support, experience and mentorship to new residents, a book that trainees across the country will benefit from having on their bookshelves. In this episode, our guests -both contributors to the chapter on telepsychiatry- share their experiences and perspectives around the pros and cons of moving to a remote, digital workspace, how Covid-19 has accelerated our societal transition to reliance on video-screens, and the challenges posed by new technology. In this episode: Introduction (0:09) This episode's guests (1:14) Post-pandemic changes in the role of telepsychiatry (6:20) The experience of a trainee during Covid-19 (8:59) Experiences with different platforms (12:12) Advantages of telepsychiatry (13:53) Whither telepsychiatry? (18:37) Interstate regulation (24:00) Malpractice (25:39) Consent and documentation (29:00) Emergencies (34:00) Platforms and the role of AI (37:01) The age spectrum, and privacy concerns (39:14) Conclusion (42:20) Alka Mathur M.D. is a Stanford trained Psychiatrist where she is a Clinical Assistant Professor on the Affiliate Faculty Line. She previously served as the Medical Director of Virtual Behavioral Health Services for the VA Palo Alto Healthcare System, overseeing Telehealth services for all Mental Health Programming. Dr. Mathur has a strong interest in health innovation and digital applications to increase access to care. Neal Amin M.D., Ph.D. is a Clinical Assistant Professor in the Department of Psychiatry at Stanford University. He completed the Research Track Psychiatry Residency Program at Stanford University. He earned his MD and PhD degrees from the University of California, San Diego where he conducted his graduate studies at the Salk Institute for Biological Studies. Other podcasts from the APA
This episode is sponsored by Netsuite by Oracle, the number one cloud financial system, streamlining accounting, financial management, inventory, HR, and more. Download NetSuite's popular KPI Checklist, designed to give you consistently excellent performance - absolutely free at https://netsuite.com/EYEONAI Join host Craig Smith in episode #178 of Eye on AI for an enlightening conversation with Terry Sejnowski, President of the NeurIPS Foundation and is the Francis Crick Professor at the Salk Institute for Biological Studies where he directs the Computational Neurobiology Laboratory In this episode, Terry shares his unique insights into the evolution of neural networks, the monumental impact of models like GPT-4, and the intricate relationship between AI technologies and societal norms. Learn about the future trajectory of AI development, as Terry highlights the importance of integrating human brain development aspects into AI to foster models that better understand and integrate into human culture. Discover Terry's perspective on the role of reinforcement learning in AI, the challenges of aligning AI with ethical considerations, and the potential of neuromorphic engineering to revolutionize energy-efficient computing. This discussion also touches on the implications of AI in reshaping industries, science, and the global workforce. An essential listen for those fascinated by the ethical dimensions of AI, the potential of neuroscience to inform AI development, and the broader societal impacts of technological advancement. If you're drawn to the complexities of AI and its potential to redefine our future, don't forget to rate us on Apple Podcast and Spotify. Stay Updated: Craig Smith Twitter: https://twitter.com/craigss Eye on A.I. Twitter: https://twitter.com/EyeOn_AI (00:00) Introduction to Terry Sejnowski (01:54) Bridging Computational Neuroscience with AI Development (05:24) Biological Principles in AI: Learning and Adaptation (07:07) The Crucial Role of Reinforcement Learning in AI (10:12) Breakthroughs in AI: Scaling Models and Language Processing (13:38) The Rapid Pace of AI Evolution: Implications and "AI Time" (16:58) Ethical Considerations and AI Alignment Challenges (20:23) Neuromorphic Engineering and Energy Efficiency (25:42) Real-world Applications: AI's Expanding Role in Society (29:04) The Developmental Approach: Training AI with Human Nuances (33:32) The Impact of AI on Science and Discovery (40:19) AI Education and Lifelong Learning: Overcoming Barriers (43:20) MOOCs and the Democratization of Learning in the AI Era (47:08) Balancing Innovation and Safety in the Accelerating AI Landscape
In this episode, my guest is Dr. Kay Tye, PhD, Professor of Systems Neurobiology at the Salk Institute for Biological Studies and a Howard Hughes Medical Institute (HHMI) Investigator. We discuss the neural circuit basis of social interactions and loneliness. We also discuss how animals and people establish themselves in a group hierarchy by rank and how the brain responds to dominance and subordination. Much of our discussion relates to how social media impacts our sense of social connectedness or lack thereof. The topics covered in this episode are directly relevant to anyone interested in the neuroscience of mental health, work-life balance, abundance versus scarcity mindset, and interpersonal dynamics. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Levels: https://levels.link/huberman LMNT: https://drinklmnt.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Kay Tye (00:02:39) Sponsors: Eight Sleep, Levels & LMNT (00:06:40) Amygdala; “Valence” (00:12:43) Novelty; Reward & Punishment Response (00:20:06) Amygdala & Hunger; Social Interaction (00:26:21) Social Media & Social Connection; Tool: Email & Time Management (00:35:03) Sponsor: AG1 (00:36:30) Social Media; Friction & Feedback, Leadership (00:43:44) Social Isolation, Harlow Experiments, “Loneliness Neurons” (00:51:47) Social Homeostasis, COVID-19 Pandemic & Loneliness (01:01:29) Quality of Social Contact, Social Homeostasis, Social Media (01:08:40) Sponsor: InsideTracker (01:09:42) Social Media, Relationships; Social Isolation & Exclusion (01:18:26) Empathy: Friend vs. Foe (01:28:40) Background & Empathy, Diversity, Emotional Regulation (01:34:34) Abundance vs. Scarcity Mindset (01:37:22) Social Rank & Hierarchy, Sibling Order, Development (01:45:54) Dynamic Hierarchy; Dominants vs. Subordinates; Mentors (01:55:32) Psychedelics: Research & Mechanisms; Psilocybin (02:06:28) Work-Life Balance, Fitness & Extracurriculars (02:11:56) Personal Life, Diversity, Happiness; Typical Day (02:15:42) Science & Academia; Future Directions (02:23:48) Research & Science Outreach (02:28:48) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer
Dr. Satchin Panda is a professor at the Salk Institute for Biological Studies and a leading expert in the fields of time restricted eating (TRE), circadian biology and circadian rhythm research. Today we discuss: Why you should care about your circadian rhythm and the signs that your circadian clock is misaligned, how to optimize your circadian rhythm to improve sleep quality and your overall health, the science of intermittent fasting and proper techniques to fast effectively, the most beneficial times to view light and when it's best to stop viewing light, the insane benefits of following a well structured schedule and much more. ⚠ WELLNESS DISCLAIMER ⚠ Please be advised; the topics related to health and mental health in my content are for informational, discussion, and entertainment purposes only. The content is not intended to be a substitute for professional advice, diagnosis, or treatment. Always seek the advice of your health or mental health professional or other qualified health provider with any questions you may have regarding your current condition. Never disregard professional advice or delay in seeking it because of something you have heard from your favorite creator, on social media, or shared within content you've consumed. If you are in crisis or you think you may have an emergency, call your doctor or 911 immediately. If you do not have a health professional who is able to assist you, use these resources to find help: Emergency Medical Services—911 If the situation is potentially life-threatening, get immediate emergency assistance by calling 911, available 24 hours a day. National Suicide Prevention Lifeline, 1-800-273-TALK (8255) or https://suicidepreventionlifeline.org. SAMHSA addiction and mental health treatment Referral Helpline, 1-877-SAMHSA7 (1-877-726-4727) and https://www.samhsa.gov Learn more about your ad choices. Visit megaphone.fm/adchoices
Imagine a future where you can get the benefits of exercise without ever having to lift a weight, where AI is used to protect our data and find alien life, and where anime is even more popular than it is today. In this episode, we'll explore all of these possibilities and more, as we discuss the latest breakthroughs in science, technology, and culture. Tune in to learn how we can create a better future for everyone! Social MediaIG ---------- [ https://bit.ly/IG-LTS ]LTS Email & Inquiries ---------- [ lifetechsundry@gmail.com ]LTS Twitter ---------- [ https://bit.ly/LTSTweets ]Donate To LTS ---------- [ https://bit.ly/LTSDonos ]Buy Me Coffee ---------- [ https://www.buymeacoffee.com/LTS2020 ] Sources: "Exercise-mimicking drug sheds weight, boosts muscle activity in mice." ScienceDaily, 25 Sep. 2023. "New study shows how to boost muscle regeneration and rebuild tissue." Salk Institute for Biological Studies, 25 May 2021. "Gene therapy in mice builds muscle, reduces fat." Washington University School of Medicine in St. Louis, 8 May 2020. "NSA Warns of AI's Potential to Amplify Cyberattacks." AP News, 28 Sept. 2023, [link](https://www.apnews.com/article/technology-business-science-nsa-cybersecurity-9f0c8c9d8a7f5e4a6b4b1c0d1c2a3b7f). "Scientists Created AI That Could Detect Alien Life — and They're Not Entirely Sure How It Works." Live Science, 28 Sept. 2023, [link](https://www.livescience.com/space/extraterrestrial-life/scientists-created-ai-that-could-detect-alien-life-and-theyre-not-entirely-sure-how-it-works). "AI Voice Translation Pilot: Lex Fridman, Dax Shepard, Steven Bartlett." Spotify Newsroom, 25 Sept. 2023, [link](https://newsroom.spotify.com/2023-09-25/ai-voice-translation-pilot-lex-fridman-dax-shepard-steven-bartlett/). Scott Pilgrim Takes Off Anime Series Streams Video Clip. Anime News Network, September 27, 2023. Link: ^1^ Netflix Unveils ‘Tomb Raider,' ‘Devil May Cry' Anime Teasers, Date. The Hollywood Reporter, September 28, 2023. Link: ^2^ “Government-Organized Studio Ghibli-Themed Matchmaking Event Bombarded with Applications.” Anime News Network, 28 Sept. 2023, [link]. --- Send in a voice message: https://podcasters.spotify.com/pod/show/ltspodcast/message Support this podcast: https://podcasters.spotify.com/pod/show/ltspodcast/support
In this episode, host, Geoffrey Rubin, MD, MBA, FACR, talks with William R. Brody, MD, PhD, Professor and President Emeritus at The Johns Hopkins University and the Salk Institute for Biological Studies. ********** RLI Taking the Lead listeners can save 12% on the 2023 RLI Summit, taking place September 29 – October 1 at the Seaport Hotel in Boston. To take advantage of this exclusive listener offer, visit acr.org/RLIsummit and use code RLITTL12 at checkout. We hope to see you there! To learn more about RLI programs and other resources, visit acr.org/rli.
The fourth Season of the National Institute of Neurological Disorders and Stroke's Building Up the Nerve podcast, where we discuss the unwritten rules, or “hidden curriculum,” of scientific research at every career stage. We know that navigating your career can be daunting, but we're here to help—it's our job! In episode 2, we talk about what to do next after your bachelor's degree, specifically focusing on the gap year or years between finishing undergrad and starting a PhD.And just as a note to our listeners, we do talk about heavier subjects like miscarriage, so we have put chapter markers if you'd like to skip that section.Featuring Cheyanne Lewis, Doctoral Student, Stanford University; Christian Cazares, Postdoctoral Fellow, Salk Institute for Biological Studies; and Gabriela Gomez, MD, MPH Candidate, Johns Hopkins University. Resources Programs:Colors of the Brain program, co-founded by Dr. Cazares: https://colorsofthebrain.com/resources/ NIH Postbacc Intramural Research Training Award (IRTA): https://www.training.nih.gov/programs/postbac_irta Maximizing Access to Research Careers (MARC) programs (e.g. at UC Berkeley): https://mcb.berkeley.edu/marc/marc-program-descriptionOrganizations: Society for Advancement of Chicanos/Hispanics & Native Americans in Science (SACNAS): https://www.sacnas.org/ Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS): https://abrcms.org/ Association of Science Communicators: https://www.associationofsciencecommunicators.org/ Black in Neuro: https://blackinneuro.com/undergraduates Científico Latino: https://www.cientificolatino.com/post-bac "Skill development in graduate education": https://pubmed.ncbi.nlm.nih.gov/22633484/"So You Want to Be a Neuroscientist?" by Prof. Ashley Juavinett: http://cup.columbia.edu/book/so-you-want-to-be-a-neuroscientist/9780231190893 Transcript available at http://ninds.buzzsprout.com/.
This week's episode of The Metabolic Link features an enlightening conversation between our host Dr. Dominic D'Agostino and Dr. Satchin Panda, PhD on the fascinating connection between time-restricted eating, circadian rhythm, and metabolic health. A leading expert in the field of circadian rhythm research, Dr. Panda is a professor at the Salk Institute for Biological Studies and a founding executive member of the Center for Circadian Biology at the University of California.Have you been hearing lately about the importance of morning light exposure?Well, you have Dr. Satchin Panda's research to thank for that. His research discovered that melanopsin cells in our retinas detect sunlight and send signals to our pineal gland - ultimately regulating the release of melatonin and other neurotransmitters responsible for the natural timing of circadian rhythms.And just as metabolic health is inextricably linked to most, if not all, biological processes in the human body, Dr. Panda's work explores the genes, molecules and cells that keep the whole body on the circadian clock.In this episode, we cover:Research contrasting the effects of time-restricted eating vs. calorie-restriction for weight loss and metabolic health biomarkersThe benefits and sustainability of time-restriction vs. calorie-restriction for the average patientMelatonin's role in both circadian rhythm and metabolic function…and 3 things anyone can do to optimize their circadian biologyIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
Your brain, your heart -- in fact, every cell in your body -- has its own clock telling you when to be alert and when to pack it in. You probably know that jet lag and daylight savings time affect that clock, but did you know that the food you eat (and when you eat it) as well as your activity level can also wreak havoc on it? Emily Manoogian, PhD, chronobiologist and clinical researcher at the Salk Institute for Biological Studies in San Diego, explains how shift work, long flights, eating at the wrong times, and even staying up too late on weekends all affect health, mood, and emotional regulation. Plus - what happens when animals are thrown off their rhythm?
This episode is brought to you by Birch Mattress by Helix and LMNT. Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Satchin Panda to dive deep into his groundbreaking circadian biology research and how leveraging your circadian rhythm can dramatically improve your sleep, lower your risk of chronic disease, and improve your cognitive function. They also discuss how time-restricted eating, exercise, and light can be used to help program your circadian rhythm and why it's especially important for shift workers to take advantage of these tools. Dr. Panda is pioneering circadian biology research. He is a professor at the Salk Institute for Biological Studies, a Pew Biomedical Scholar, founder of the UC San Diego Center for Circadian Biology, and recipient of the Julie Martin Mid-Career Award in Aging Research. Dr. Panda has spoken at conferences around the world about his work on circadian rhythms and diabetes, including Diabetes UK, the American Diabetes Association, the Danish Diabetes Association, and the professional diabetes societies of Europe and Australia.In this episode, Dhru and Dr. Panda dive into:-Why late-night eating is so detrimental to our health (2:15)-Organ systems that have a circadian rhythm (8:24)-Common ailments that could be related to circadian rhythm disturbances (14:11)-Night-shift work and cancer risk (20:19)-How poor sleep perpetuates bad food choices (27:00)-What happens in the body when you rely on an alarm clock (44:09)-Why you need to accumulate sleep debt for better sleep (51:55)-Time-restricted eating and sleep (1:00:56)-How to combat fragmented sleep (1:16:16)-The best time to work out (1:55:48)-The link between exercise and cancer (2:08:04)-Positive changes for better sleep health on a global scale (2:18:06)-Strategies for night-shift workers to combat circadian rhythm disruption (2:45:40)-Dr. Panda's research in firefighters (2:49:42)-Tips for optimizing your circadian rhythm (3:14:20)Also mentioned in this episode:-The Circadian Code-The Circadian Diabetes Code-Download the MyCircadianClock app-Download the Ontime app, an app to help you reprogram your circadian rhythm-Try This: 6 Crazy Facts About Sleep-Try This: How Exercise Helps Fight CancerFor more on Dr. Satchin Panda, follow him on Twitter @SatchinPanda or Instagram @satchin.panda.Birch Mattress by Helix is made out of organic latex, organic cotton, New Zealand wool, and American steel springs. To get 20% off your Birch Living mattress plus two free eco-rest pillows, head over to birchliving.com/dhru today.Right now, LMNT is offering my listeners a free sample pack with any purchase. That's eight single-serving packets FREE with any LMNT order. This is a great way to try all eight flavors or share LMNT with a salty friend. Get yours at DrinkLMNT.com/DHRU. Hosted on Acast. See acast.com/privacy for more information.
Your brain, your heart -- in fact, every cell in your body -- has its own clock telling you when to be alert and when to pack it in. Dr. Emily Manoogian, chronobiologist at the Salk Institute for Biological Studies explains how disrupting your circadian rhythms through shift work, long flights, eating at the wrong times, and even staying up too late on weekends can affect your health, mood, and emotional regulation.
Prepare to be amazed as we welcome the exceptional Dr. Satchin Panda to our podcast! His groundbreaking research on circadian rhythms and sleep has made waves in the health community, and we're thrilled to share his invaluable insights with you.Dr. Panda is a leading expert in circadian rhythm research, a professor at the Salk Institute for Biological Studies, and a founding executive member of the Center for Circadian Biology at the University of California.His expertise has earned him recognition worldwide, including speaking engagements at esteemed conferences on diabetes and circadian rhythms.But wait, this episode isn't just for those with diabetes! Dr. Panda's findings have a significant impact on all of us…including on your sleep results! Discover the astonishing influence of meal timing on your sleep quality, energy levels, and overall vitality. Whether you're a health enthusiast or simply seeking to optimize your well-being, this conversation is a game-changer.Join us as we explore the blueprint for incorporating these principles into your daily life. We'll delve into the fascinating world of circadian rhythms and learn how Dr. Panda himself manages his sleep, nighttime, and morning routine. Don't miss this opportunity to unlock the secrets of circadian rhythms with Dr. Sachin Panda.BIO:Satchin Panda, PhD, is a leading expert in the field of circadian rhythm research. He is a professor at the Salk Institute for Biological Studies and a founding executive member of the Center for Circadian Biology at the University of California, San Diego. Dr. Panda is a Pew Biomedical Scholar and a recipient of the Julie Martin Mid-Career Award in Aging Research. As a recognition of the impact of his work regarding circadian rhythms and diabetes, Dr. Panda has been invited to speak at conferences around the world, including Diabetes UK, the American Diabetes Association, the Danish Diabetes Association, and the respective professional diabetes societies of Europe and Australia.SHOW NOTES:
Satchin Panda, PhD is a prominent circadian biologist and professor at the Salk Institute for Biological Studies. He has made significant contributions to the field, including developing a time-restricted feeding regimen to improve metabolic health in humans. His latest book is The Circadian Diabetes Code: Discover the Right Time to Eat, Sleep, and Exercise to Prevent and Reverse Prediabetes and Diabetes. Become a Genius Life Premium Member and get ad-free episodes of the show and more! Learn more: http://thegeniuslife.com
Hoy te cuento acerca de la información más reciente acerca del Ayuno Intermitente para optimizar tu enfoque, vitalidad y longevidad. Me referí a estudios del Doctor Satchin Panda, PHD profesor y director del Regulatory Biology Laboratories at the Salk Institute for Biological Studies y su conversación con el Doctor Huberman.Inscripciones Abiertas Para Fast4life Abril 17 - programa de 4 Semanas Ayuno Intermitente para balance hormonal y metabólico. Para mejorar tu salud, quemar grasa y longevidad.Cupo Limitado ⚡️ https://proud-heart-742.myflodesk.comTemas que hablamos:Reloj Biológico y el mejor horario para tu ventana de alimentosEstudios de LongevidadRecomendación de Horas de Ayuno Intermitente según tu actividad físicaTodo acerca del Café y como surgió el DESAYUNOCuántas horas debemos dormir y mejor hora para acostarteEstudio de Bomberos y Personas que trabajan de noche o se desvelan mucho.Espero te guste este episodio y que lo compartas con alguien!Te quiero y estoy orgullosa de Tí,MarisDescargo de Responsabilidad: Este video, guía, reto, audio es para información general solamente. No debe ser usado para diagnosticar y no es sustituto de un examen médico, ni para curar, tratar, prescribir ninguna enfermedad. No crea una relación nutricionista-cliente entre Maris Rodriguez y tú. Tu no debes hacer ningún cambio a las indicaciones de tu médico o ninguna dieta sin antes consultar con tu médico de cabecera. Siempre pregúntale a tu medico, nutricionista o algún otro médico calificado Cualquier pregunta o duda que tengas acerca de tu condición médica. Maris Rodriguez LLC, MARIS RODRIGUEZ y MÉTODO MARIS no son responsables por ningún consejo, tratamiento, diagnóstico médico o cualquier otra información, servicios o productos que tu obtengas por medio de este video o sitio web. Maris Rodriguez te comparte lo que le ha funcionado a ella para vivir una vida saludable y sin obesidad y no pretende darte ningún consejo médico.
Professor Satchin Panda is a leading expert in the field of circadian rhythm research. He is a professor at the Salk Institute for Biological Studies and a founding executive member of the Center for Circadian Biology at the University of California, San Diego. Dr. Panda is a Pew Biomedical Scholar and a recipient of the Julie Martin Mid-Career Award in Aging Research. As a recognition of the impact of his work regarding circadian rhythms and diabetes, Dr. Panda has been invited to speak at conferences around the world, including Diabetes UK, the American Diabetes Association, the Danish Diabetes Association, and the respective professional diabetes societies of Europe and Australia. Important: This conversation does not constitute medical advice. All topics discussed are for informational and entertainment purposes only, and NOT a substitute for medical advice. The Freedom Pact Podcast, and guests assume no liability for the application of the information discussed. Topics discussed: Why Satchin's Grandparents had two different health outcomes What is a circadian rhythm? Health damage caused by a faulty circadian rhythm The Benefits Of Morning sunlight Mobile Phones offset circadian rhythm Night owls vs morning larks Time restricted eating Any downsides into Intermittent fasting? The 6 Pillars To Resetting Your Clock Satchin's app What makes Satchin's life worth living? Book discussed: Buy 'The circadian code '- HERE: https://www.amazon.co.uk/Circadian-Code-Weight-Supercharge-Energy/dp/B07R6P6ZCQ/ref=sr_1_1?crid=1F7H3C0DK89FY&keywords=the+circadian+code&qid=1679050533&sprefix=the+circadian+cod%2Caps%2C131&sr=8-1 Connect with Dr. Satchin Panda Salk Institute: https://www.salk.edu/scientist/satchidananda-panda Panda Lab: https://panda.salk.edu Publications: https://panda.salk.edu/publications Support Dr. Panda's Research: https://panda.salk.edu/giving Twitter: https://twitter.com/SatchinPanda Instagram: https://www.instagram.com/satchin.panda Other Resources My Circadian Clock app: https://mycircadianclock.org Ontime Health app: https://getontimehealth.com Instagram: https://www.instagram.com/getontimehealth Connect with us: YouTube.com/freedompact (video interviews) https://freedompact.co.uk/newsletter (Healthy, Wealthy & Wise Newsletter) https://instagram.com/freedompact https://twitter.com/freedompactpod freedompact@gmail.com
James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper proposing the double helix structure of the DNA molecule. Watson, Crick and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". Watson earned degrees at the University of Chicago (BS, 1947) and Indiana University (PhD, 1950). Following a post-doctoral year at the University of Copenhagen with Herman Kalckar and Ole Maaløe, Watson worked at the University of Cambridge's Cavendish Laboratory in England, where he first met his future collaborator Francis Crick. From 1956 to 1976, Watson was on the faculty of the Harvard University Biology Department, promoting research in molecular biology. From 1968, Watson served as director of Cold Spring Harbor Laboratory (CSHL), greatly expanding its level of funding and research. At CSHL, he shifted his research emphasis to the study of cancer, along with making it a world-leading research center in molecular biology. In 1994, he started as president and served for 10 years. He was then appointed chancellor, serving until he resigned in 2007 after making comments claiming that there is a genetic link between intelligence and race. In 2019, following the broadcast of a documentary in which Watson reiterated these views on race and genetics, CSHL revoked his honorary titles and severed all ties with him. Watson has written many science books, including the textbook Molecular Biology of the Gene (1965) and his bestselling book The Double Helix (1968). Between 1988 and 1992, Watson was associated with the National Institutes of Health, helping to establish the Human Genome Project, which completed the task of mapping the human genome in 2003. ___________________________________________________________ Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was an English molecular biologist, biophysicist, and neuroscientist. He, James Watson, Rosalind Franklin, and Maurice Wilkins played crucial roles in deciphering the helical structure of the DNA molecule. Crick and Watson's paper in Nature in 1953 laid the groundwork for understanding DNA structure and functions. Together with Maurice Wilkins, they were jointly awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". Crick was an important theoretical molecular biologist and played a crucial role in research related to revealing the helical structure of DNA. He is widely known for the use of the term "central dogma" to summarise the idea that once information is transferred from nucleic acids (DNA or RNA) to proteins, it cannot flow back to nucleic acids. In other words, the final step in the flow of information from nucleic acids to proteins is irreversible. During the remainder of his career, he held the post of J.W. Kieckhefer Distinguished Research Professor at the Salk Institute for Biological Studies in La Jolla, California. His later research centered on theoretical neurobiology and attempts to advance the scientific study of human consciousness. He remained in this post until his death; "he was editing a manuscript on his death bed, a scientist until the bitter end" according to Christof Koch. Original video here Full Wikipedia entry for James Watson here | James Watson's books here Full Wikipedia entry for Francis Crick here | Francis Crick's books here --- Support this podcast: https://podcasters.spotify.com/pod/show/theunadulteratedintellect/support
Dr. Satchin Panda, a leading expert in circadian rhythm research and a professor at the Salk Institute for Biological Studies, discusses the benefits of time-restricted feeding and how it could have profound impacts on our health and chronic conditions like diabetes and even obesity. Follow Dr. Panda on Twitter Learn more about the Salk Institute & Dr. Panda's research Dr Panda's work has inspired the Ontime Health app and community. Here members learn and develop healthy habits around the pillars of circadian health; fasting, sleep, exercise and light. Learn more and join the community at : GetOntimeHealth.com/Blueprint Instagram: @getontimehealth Sign up for Erik's weekly newsletter - Adaptation Join the AIM7 Beta Community Episode 3 Quotable moments: 40:18 *“We discovered that just like light and darkness boosts our circadian rhythm and the brain, eating, fasting, and maintaining that rhythm consistently boosts our circadian rhythm in the rest of the body.” 48:00 “What we see with time-restricted feeding in animals is this immune function is tuned to the right level. It's not too high and it's not too low. One more thing that we see is gut microbiome becomes more diverse, and also we have more beneficial microbes.” 49:41 “In human studies, those who can do eight to 10 hours of time-restricted eating, even if they did it for three months minimum, saw a reduction in LDL cholesterol and reduction in triglyceride.* ABOUT THE BLUEPRINT PODCAST: The BluePrint Podcast is for busy professionals and Household CEOs who care deeply about their families, career, and health. Host Dr. Erik Korem distills cutting edge-science, leadership, and life skills into simple tactics optimized for your busy lifestyle and goals. Dr. Korem interviews scientists, coaches, elite athletes, entrepreneurs, entertainers, and exceptional people to discuss science and practical skills you can implement to become the most healthy, resilient, and impactful version of yourself. On a mission to equip people to pursue audacious goals, thrive in uncertainty, and live a healthy and fulfilled life, Dr. Erik Korem is a High Performance pioneer. He introduced sports science and athlete tracking technologies to collegiate and professional (NFL) football over a decade ago. He has worked with the National Football League, Power-5 NCAA programs, gold-medal Olympians, Nike, and the United States Department of Defense. Erik is an expert in sleep and stress resilience. He is the Founder and CEO of AIM7, a health and fitness app that unlocks the power of wearables by providing you with daily personalized recommendations to enhance your mind, body, and recovery. SUPPORT & CONNECT Instagram - https://www.instagram.com/erikkorem/ Twitter - https://twitter.com/ErikKorem LinkedIn - https://www.linkedin.com/in/erik-korem-phd-19991734/ Facebook - https://www.facebook.com/erikkorem Website - https://www.erikkorem.com/ Newsletter - https://erikkoremhpcoach.activehosted.com/f/ See omnystudio.com/listener for privacy information.
Huberman Lab Podcast Notes “When it comes to nutrition, quality, quantity, and timing – all these three matter.” – Dr. Satchin PandaIntermittent fasting really means caloric restriction; time-restricted eating doesn't necessarily reduce caloric intake but does reduce the time of eating food (for example, 16hrs fasting and 8 hours of eating)Consistency is a critical component of TRE: our body has an internal timetable that pre-programs molecular aspects of the cells – they want to do certain things at certain times; we can use feeding to tune our cells Adhere at least 5 days per week; obviously, every day is best but improvements have been observed 5 out of 7 daysA feeding window of 10 or 12 hours is a good place to start (particularly if you exercise), then taper down to 8 hours of feeding if it feels right for you Be advised, reducing the feeding window too much can have negative side effects, particularly for athletes or very active peopleMost studies exclude shift workers because of schedule and known disruption to physical and mental health – even 1-2 nights of being awake when you expect to sleep can take a week to recoverRead the full notes @ podcastnotes.orgIn this episode, my guest is Satchin Panda, PhD, professor and the director of the Regulatory Biology Laboratories at the Salk Institute for Biological Studies. We discuss his lab's discovery that “time-restricted eating” (TRE) aka intermittent fasting, is beneficial effects for metabolic health and longevity. Dr. Panda explains how TRE, and also longer fasts, can positively impact obesity, diabetes, cardiovascular health, age-related chronic diseases, and improve mood and cognitive performance. He also describes how the timing of eating, light exposure and exercise that ~50% of all people engage in, negatively impacts their health and explains how specific simple adjustments to these can positively shift their subjective feelings of health and biomarkers of cardiovascular function, glucose regulation and metabolism. We discuss how our circadian behaviors, which include our patterns of eating, sleeping and socializing, have an enormous impact on our biology, mood and health and how by simply confining our calorie consumption to a semi-regular daily window, can positively impact our physical health, mental health and longevity. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman HVMN: https://hvmn.com/huberman Eight Sleep: https://eightsleep.com/huberman Thesis: https://takethesis.com/huberman Momentous: https://www.livemomentous.com/huberman InsideTracker: https://www.insidetracker.com/huberman Timestamps (00:00:00) Dr. Satchin Panda (00:03:02) Sponsors: HVMN, Eight Sleep, Thesis, Momentous (00:07:24) Time-Restricted Eating (TRE), Calorie Restriction (CR) & Health (00:14:38) Mealtimes & Circadian Clock (00:21:34) Circadian Rhythm, Meal Anticipation, Digestion (00:25:28) Breaking a Fast, Burning Fat (00:32:49) Sponsor: AG1 (Athletic Greens) (00:34:04) CR, Time Restricted Eating, Circadian Rhythm & Longevity (00:47:20) Gender, Hormones & CR; Relative Energy Deficient in Sports (REDS) (00:52:40) Physical Activity, Nutrition & Feeding Window (00:59:04) Nutrition Timing, Quality & Quantity; Low- Carbohydrate Diet (01:03:00) Caffeine, Nighttime Socialization, Fire, Breakfast (01:15:07) Sponsor: InsideTracker (01:16:20) Circadian Rhythm, “Night Owls” & Genetics (01:26:37) Morning vs. Nighttime Discussions, “Me Time” (01:30:08) Light Sensitivity & “Night Owls”; Puberty, Melatonin (01:36:05) Shift Workers, Health & Disease (01:45:43) Artificial Lights, Young Adults & Sleep, Metabolic Dysfunction (01:50:59) Firefighters, Sleep & TRE; Cardiovascular Health, Blood Glucose (02:05:18) Shift Workers & Sleep; Alcohol & Caffeine (02:09:15) 12- Hour Feeding Window for Adults & Children, Sleep (02:22:10) Meal Timing (02:25:20) “Complete Fast”, Longer Fasts, Physical Health & Mental Health (02:28:12) “Fat Fasting”, Blood Glucose & Insulin (02:31:57) Fasting, Metformin, Rapamycin & Longevity; Human Applicability? (02:39:14) Circadian Rhythm & Metabolism (02:41:36) Ontime Health App, Circadian Clock App (02:46:17) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer
In this episode, my guest is Satchin Panda, PhD, professor and the director of the Regulatory Biology Laboratories at the Salk Institute for Biological Studies. We discuss his lab's discovery that “time-restricted eating” (TRE) aka intermittent fasting, is beneficial effects for metabolic health and longevity. Dr. Panda explains how TRE, and also longer fasts, can positively impact obesity, diabetes, cardiovascular health, age-related chronic diseases, and improve mood and cognitive performance. He also describes how the timing of eating, light exposure and exercise that ~50% of all people engage in, negatively impacts their health and explains how specific simple adjustments to these can positively shift their subjective feelings of health and biomarkers of cardiovascular function, glucose regulation and metabolism. We discuss how our circadian behaviors, which include our patterns of eating, sleeping and socializing, have an enormous impact on our biology, mood and health and how by simply confining our calorie consumption to a semi-regular daily window, can positively impact our physical health, mental health and longevity. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman HVMN: https://hvmn.com/huberman Eight Sleep: https://eightsleep.com/huberman Thesis: https://takethesis.com/huberman Momentous: https://www.livemomentous.com/huberman InsideTracker: https://www.insidetracker.com/huberman Timestamps (00:00:00) Dr. Satchin Panda (00:03:02) Sponsors: HVMN, Eight Sleep, Thesis, Momentous (00:07:24) Time-Restricted Eating (TRE), Calorie Restriction (CR) & Health (00:14:38) Mealtimes & Circadian Clock (00:21:34) Circadian Rhythm, Meal Anticipation, Digestion (00:25:28) Breaking a Fast, Burning Fat (00:32:49) Sponsor: AG1 (Athletic Greens) (00:34:04) CR, Time Restricted Eating, Circadian Rhythm & Longevity (00:47:20) Gender, Hormones & CR; Relative Energy Deficient in Sports (REDS) (00:52:40) Physical Activity, Nutrition & Feeding Window (00:59:04) Nutrition Timing, Quality & Quantity; Low- Carbohydrate Diet (01:03:00) Caffeine, Nighttime Socialization, Fire, Breakfast (01:15:07) Sponsor: InsideTracker (01:16:20) Circadian Rhythm, “Night Owls” & Genetics (01:26:37) Morning vs. Nighttime Discussions, “Me Time” (01:30:08) Light Sensitivity & “Night Owls”; Puberty, Melatonin (01:36:05) Shift Workers, Health & Disease (01:45:43) Artificial Lights, Young Adults & Sleep, Metabolic Dysfunction (01:50:59) Firefighters, Sleep & TRE; Cardiovascular Health, Blood Glucose (02:05:18) Shift Workers & Sleep; Alcohol & Caffeine (02:09:15) 12- Hour Feeding Window for Adults & Children, Sleep (02:22:10) Meal Timing (02:25:20) “Complete Fast”, Longer Fasts, Physical Health & Mental Health (02:28:12) “Fat Fasting”, Blood Glucose & Insulin (02:31:57) Fasting, Metformin, Rapamycin & Longevity; Human Applicability? (02:39:14) Circadian Rhythm & Metabolism (02:41:36) Ontime Health App, Circadian Clock App (02:46:17) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer
Dr. Satchin Panda, a leading expert in circadian rhythm research and a professor at the Salk Institute for Biological Studies, delivers a masterclass on how to boost melatonin levels to improve sleep naturally. He also details the potential dangers of using slow-release melatonin and how to modify your eating patterns to optimize blood glucose control. Follow Dr. Panda on Twitter Learn more about the Salk Institute & Dr. Panda's research Dr. Panda's work has inspired the Ontime Health app and community. Here members learn and develop healthy habits around the pillars of circadian health; fasting, sleep, exercise, and light. Learn more and join the community at: GetOntimeHealth.com/Blueprint Instagram: @getontimehealth Sign up for Erik's weekly newsletter - Adaptation Join the AIM7 Beta Community Quotable moments: 31:16 “The rule of thumb is, two hours before habitual bedtime melatonin begins. That means we should not be eating two and a half hours before going to bed because when we eat, our blood glucose level will begin to rise and they stay high for 30 to 90 minutes.” 34:11 “But the difference between a car and the human body is the car cannot self-repair. in every three months to six months, you are taking the car for repairs. You cannot drive the car when it's in the repair shop, and you cannot drive your body and fuel it when it's supposed to repair.” 37:53 "If you go take a walk outside, or even if you open the window on a sunny day, sit next to the window, you're getting 4,000 to 5,000, lots of light for an hour which somehow increases nightly production of melatonin.” ABOUT THE BLUEPRINT PODCAST: The BluePrint Podcast is for busy professionals and Household CEOs who care deeply about their families, career, and health. Host Dr. Erik Korem distills cutting edge-science, leadership, and life skills into simple tactics optimized for your busy lifestyle and goals. Dr. Korem interviews scientists, coaches, elite athletes, entrepreneurs, entertainers, and exceptional people to discuss science and practical skills you can implement to become the most healthy, resilient, and impactful version of yourself. On a mission to equip people to pursue audacious goals, thrive in uncertainty, and live a healthy and fulfilled life, Dr. Erik Korem is a High Performance pioneer. He introduced sports science and athlete tracking technologies to collegiate and professional (NFL) football over a decade ago. He has worked with the National Football League, Power-5 NCAA programs, gold-medal Olympians, Nike, and the United States Department of Defense. Erik is an expert in sleep and stress resilience. He is the Founder and CEO of AIM7, a health and fitness app that unlocks the power of wearables by providing you with daily personalized recommendations to enhance your mind, body, and recovery. SUPPORT & CONNECT Instagram - https://www.instagram.com/erikkorem/ Twitter - https://twitter.com/ErikKorem LinkedIn - https://www.linkedin.com/in/erik-korem-phd-19991734/ Facebook - https://www.facebook.com/erikkorem Website - https://www.erikkorem.com/ Newsletter - https://erikkoremhpcoach.activehosted.com/f/ See omnystudio.com/listener for privacy information.
Dr. Satchin Panda, a leading expert in circadian rhythm research and a professor at the Salk Institute for Biological Studies, explains how our circadian rhythm impacts our immune system, inflammation, brain function, and overall human performance. Dr. Panda also describes how modern living is disrupting our circadian rhythms and behaviors we can engage in to optimize performance. Finally, he discusses the role of melatonin, its supplementation, and how our sleep patterns are affected by blue light. Follow Dr. Panda on Twitter Learn more about the Salk Institute & Dr. Panda's research Dr. Panda's work has inspired the Ontime Health app and community. Here members learn and develop healthy habits around the pillars of circadian health; fasting, sleep, exercise, and light. Learn more and join the community at: GetOntimeHealth.com/Blueprint Instagram: @getontimehealth Sign up for Erik's weekly newsletter - Adaptation Join the AIM7 Beta Community Quotable moments: 2:28 “Now the question is why we should care about our Circadian Rhythm? Because for the last 200,000 years, since humans have been on this planet, these rhythms were in sync with our day and night cycle.” 3:18 “It's a huge process that impacts every single cell of our body, every single thing that we would think is important.” 23:47 “We are in a culture that's sleep deprived. We're depriving ourselves with our devices and all sorts of different things now that are part of our lives.”* ABOUT THE BLUEPRINT PODCAST: The BluePrint Podcast is for busy professionals and Household CEOs who care deeply about their families, career, and health. Host Dr. Erik Korem distills cutting edge-science, leadership, and life skills into simple tactics optimized for your busy lifestyle and goals. Dr. Korem interviews scientists, coaches, elite athletes, entrepreneurs, entertainers, and exceptional people to discuss science and practical skills you can implement to become the most healthy, resilient, and impactful version of yourself. On a mission to equip people to pursue audacious goals, thrive in uncertainty, and live a healthy and fulfilled life, Dr. Erik Korem is a High Performance pioneer. He introduced sports science and athlete tracking technologies to collegiate and professional (NFL) football over a decade ago. He has worked with the National Football League, Power-5 NCAA programs, gold-medal Olympians, Nike, and the United States Department of Defense. Erik is an expert in sleep and stress resilience. He is the Founder and CEO of AIM7, a health and fitness app that unlocks the power of wearables by providing you with daily personalized recommendations to enhance your mind, body, and recovery. SUPPORT & CONNECT Instagram - https://www.instagram.com/erikkorem/ Twitter - https://twitter.com/ErikKorem LinkedIn - https://www.linkedin.com/in/erik-korem-phd-19991734/ Facebook - https://www.facebook.com/erikkorem Website - https://www.erikkorem.com/ Newsletter - https://erikkoremhpcoach.activehosted.com/f/ See omnystudio.com/listener for privacy information.
This week we have a surprise treat - a conversation with Jonathan's twin brother, Matt. He discusses his energetic commitment to mentoring and grant-writing workshops. They share their genetics, but also a desire to “help scientists do better science”Matthew comments on the usefulness of healthy competition in scienceMatt compares the joy of running a lab to cooking in the kitchenHe loves the flexibility of science and constantly stimulated by interactions with colleagues and young scientists and new ideasMatt makes a strong argument for peer-to-peer mentoring, cascade mentoring and seizing constant casual mentoring opportunitiesHe comments on the advantages of going to a small lab for graduate school and he advises students to look carefully at the type of scientific questions, the environment of the lab and the chemistry of the PI/mentor relationshipMatt describes his pioneering Grant Proposal Success (GPS) grant-writing program and the importance of collective, grant-writing communities. Matt dissects the grant structure and tells us what funding committees are looking forHe suggests that staggering projects and having work at different stages can help to integrate life and manage the labHe mentioned these institutions : University of Leeds, UK : https://www.leeds.ac.uk/University of Pennsylvania : https://www.upenn.edu/Children's Hospital of Philadelphia (CHOP) : https://www.chop.edu/National Institutes of Health (NIH) : https://www.nih.gov/Salk Institute for Biological Studies : https://www.salk.edu/University of California San Diego : https://ucsd.edu/To find out more about Matt visit his website or follow him on Twitter :https://twitter.com/WeitzmanLabhttps://www.chop.edu/doctors/weitzman-matthew-dhttps://pathology.med.upenn.edu/department/people/517/matthew-d-weitzman30 Second Genetics : https://www.amazon.com/30-Second-Genetics-revolutionary-discoveries-explained/dp/1782405097To find out more about Renaud :Twitter : https://twitter.com/LePourpreLinkedIn : https://www.linkedin.com/in/renaudpourpre/To find out more about Jonathan :Twitter : https://twitter.com/EpigenetiqueLinkedIn : https://www.linkedin.com/in/jonathanweitzman/%20To learn more about the soundtrack :Music by Amaria - Lovely Swindlerhttps://soundcloud.com/amariamusique/https://twitter.com/amariamusique
Next Level Soul with Alex Ferrari: A Spirituality & Personal Growth Podcast
Professor Sara C. Mednick is a cognitive neuroscientist at the University of California, Irvine and author of The Hidden Power of the Downstate (Hachette Go!, pub date: April, 2022) and Take a Nap! Change Your Life. (Workman). She is passionate about understanding how the brain works through her research into sleep and the autonomic nervous system. Dr. Mednick's seven-bedroom sleep lab works literally around-the-clock to discover methods for boosting cognition by napping, stimulating the brain with electricity, sound and light, and pharmacology. Her lab also investigates how the menstrual cycle and aging affect the brain. Her science has been continuously federally funded (National Institute of Health, National Science Foundation, Department of Defense Office of Naval Research, DARPA).Dr. Mednick was awarded the Office Naval Research Young Investigator Award in 2015. Her research findings have been published in such leading scientific journals as Nature Neuroscience and The Proceedings from the National Academy of Science, and covered by all major media outlets. She received a BA from Bard College, Annandale-on-Hudson, NY, in Drama/Dance. After college, her experience working in the psychiatry department at Bellevue Hospital in New York, inspired her to study the brain and how to make humans smarter through better sleep. She received a PhD in Psychology from Harvard University, and then completed a postdoc at the Salk Institute for Biological Studies and UC San Diego. She resides in San Diego, CA.Please enjoy my conversation with Sara Mednick.
Videos: Gary Null – Speaks to U.N. on Earth Day (Part 1 & 2) Iain McGilchrist, ‘We Need to Act' Iain McGilchrist is a former Fellow of All Souls College, Oxford, an associate Fellow of Green Templeton College, Oxford, a Fellow of the Royal College of Psychiatrists, a Fellow of the Royal Society of Arts, a Consultant Emeritus of the Bethlem and Maudsley Hospital, London, a former research Fellow in Neuroimaging at Johns Hopkins University Medical School, Baltimore, and a former Fellow of the Institute of Advanced Studies in Stellenbosch. He now lives on the Isle of Skye, off the coast of North West Scotland, where he continues to write, and lectures worldwide. California's “holy herb” Yerba Santa found to be an effective natural treatment for Alzheimer's Salk Institute for Biological Studies, September 19, 2022 Alzheimer's disease is the most common form of dementia, and aging is its primary risk factor. Therefore, researchers continue to look for ways to counter the effects of aging on the brain. In a recent study, researchers from The Salk Institute for Biological Studies discovered a potential natural treatment for Alzheimer's in the form of a medicinal herb found in California. In their study published in the journal Redox Biology, they found that yerba santa (Eriodictyon californicum), a plant native to California, contains an active compound called sterubin that could be used to treat people with Alzheimer's. Yerba santa, which is the Spanish for “holy herb,” is highly regarded as a medicine for respiratory diseases, bruising, fever, headaches, infections, and pain. For the current study, the researchers first examined 400 plant extracts with known medicinal properties for their ability to prevent oxytosis – a type of cell death that occurs in Alzheimer's disease – in mouse hippocampal nerve cells. The researchers found that sterubin exhibited the greatest protective effect against inflammation and other triggers of brain cell death. In particular, sterubin strongly reduced inflammation in microglia, which are brain cells that provide support to nerve cells. In addition, the researchers found that sterubin can remove iron from cells, helping to prevent iron accumulation. Iron accumulation can result in a type of nerve cell damage that accompanies aging and occurs in neurodegenerative problems. “Not only did sterubin turn out to be much more active than the other flavonoids in Yerba santa in our assays, it appears as good as, if not better than, other flavonoids we have studied,” said Pamela Maher, the corresponding author of the study. Vitamin B may reduce risk of stroke Zhengzhou University (China) September 23, 2022 Researchers have uncovered evidence that suggests vitamin B supplements could help to reduce the risk of stroke, according to a study published in the journal Neurology. Vitamin B supplements are said to be beneficial for many health issues, including stress, anxiety, depression, dementia, Alzheimer's disease and heart disease. However, according to Xu Yuming of Zhengzhou University in Zhengzhou, China, previous studies have conflicting findings regarding the use of vitamin B supplements and stroke or heart attack. In order to determine the role of vitamin B supplements in the risk of stroke, Prof. Yuming and colleagues analyzed 14 randomized clinical trials involving a total of 54,913 participants All studies compared use of vitamin B supplements with a placebo, or a very low dosage of the vitamin. All participants were then followed for a period of 6 months. Results of the analysis revealed that the participants taking the vitamin B supplements had a 7% reduced risk of stroke, compared with those taking the placebo supplements or a low dosage of vitamin B. The researchers found that a supplemental form of folate (vitamin B9) – a vitamin frequently found in fortified cereals – actually reduced the effect of vitamin B on the risk of stroke Additionally, the study showed that vitamin B12 did not have any effect on the risk of stroke. Ginger may protect the brain from MSG toxicity, says fascinating research University of Jeddah (Saudi Arabia), September 23, 2013 For thousands of years, ginger has been hailed as a superfood for its healing properties that aid every system of the body. The oils that ginger contains are antibacterial, antiviral and antifungal, and ginger has even been found to inhibit cancer growth. Now a study has actually proven that ginger can reverse the damage done by monosodium glutamate, or MSG, a known harmful excitotoxin. After injecting pure MSG into rats for 30 days, researchers found subsequent withdrawal caused adverse effects including significant epinephrine, norepinephine, dopamine and serotonin depletion. Low levels of these important neurotransmitters can be detrimental to health. Subsequent to injecting lab rats with MSG, researchers injected ginger root extract for 30 more days and were able to completely reverse the neurotransmitter depletion and brain damage that MSG caused. Not only that, but the positive effects of ginger were maintained even after scientists stopped administering it! A wealth of independent studies show that MSG should be avoided at all costs. Also popularly printed on food labels as hydrolyzed protein, torula or autolyzed yeast, soy or yeast extract and soy protein isolate among some 40 other names, scientists have found that consuming MSG even in low doses can cause blood glutamate levels to fluctuate abnormally high and then stay there. Anyone suffering from a disease or immunity issue that would contribute to a weakened blood-brain barrier is then much more susceptible to the chemical seeping into his or her brain and doing damage. Studies have effectively linked MSG consumption to several neurodegenerative diseases, such as Parkinson's and Alzheimer's. Men with anxiety are more likely to die of cancer, study says Cambridge University's Institute of Public Health, September 20, 2022 Men over 40 who are plagued with generalized anxiety disorder are more than twice as likely to die of cancer than are men who do not have the mental affliction, new research finds. But for women who suffer from severe anxiety, the research found no increased risk of cancer death. That finding, presented at the European College of Neuropsychopharmacology's Congress in Vienna, emerges from the largest study ever to explore a link between anxiety and cancer. It tracked 15,938 Britons over 40 for 15 years. Even after researchers took account of factors that boost the risk of cancer, including age, alcohol consumption, smoking and chronic diseases, men with a diagnosis of generalized anxiety disorder were 2.15 times as likely to die of cancer than were those with no such diagnosis. Generalized anxiety disorder – a condition marked by excessive, uncontrollable worry about many areas of life – affected women more commonly than it did men. Among women in the large cohort studied, 2.4 percent suffered from the disorder. Among men in the cohort, 1.8 percent did. Whatever the relationship, says the study's lead author, the new findings identify extremely anxious men as a population whose mental and physical health should be closely tracked. “Society may need to consider anxiety as a warning signal for poor health,” said study lead author Olivia Remes of Cambridge University's Institute of Public Health. “With this study, we show that anxiety is more than just a personality trait,” but rather, a disorder linked to real and serious health risks. Out of Over 400 Compounds Analyzed, Red Grapes and Blueberries Are Tops In Boosting Immunity – So Effective They Work As Well As Drugs Linus Pauling Institute at Oregon State University, September 18, 2022Pterostilbene, an antioxidant produced by plants has been shown to exhibit exceptional properties in fighting infections, cancer, hypertriglycerides, as well as the ability to reverse cognitive decline. It is believed that the compound also has anti-diabetic properties. In an analysis of 446 compounds for their the ability to boost the innate immune system in humans, researchers in the Linus Pauling Institute at Oregon State University discovered just two that stood out from the crowd. Red grapes and blueberies both have an exceptional ability to significantly impact immune function. In fact, pterostilbene works as well as some commercial drugs. Both of these compounds, which are called stilbenoids, worked in synergy with vitamin D and had a significant impact in raising the expression of the human cathelicidin antimicrobial peptide, or CAMP gene, that is involved in immune function.The research was published in Molecular Nutrition and Food Research, in studies supported by the National Institutes of Health. Almost a decade ago, researchers discovered that pterostilbene helps regulate blood sugar and might help fight type-2 diabetes. The finding adds to a growing list of reasons to eat colorful fruit, especially blueberries, which are rich in compounds known as antioxidants. These molecules battle cell and DNA damage involved in cancer, heart disease, diabetes and perhaps also brain degeneration. Pterostilbene works as well as the commercial drug ciprofibrate to lower the levels of fats (lipids) and triglycerides — but they worked even more accurately. They are so specific that side-effects are non-existent.”Out of a study of hundreds of compounds, just these two popped right out,” said Adrian Gombart, an LPI principal investigator and associate professor in the OSU College of Science. “Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It's a pretty interesting interaction.”This research is the first to show a clear synergy with vitamin D that increased CAMP expression by several times, scientists said.The CAMP gene itself is also the subject of much study, as it has been shown to play a key role in the “innate” immune system, or the body's first line of defense and ability to combat bacterial infection. The innate immune response is especially important as many antibiotics increasingly lose their effectiveness. Grapes don't have to be fermented to contain this antioxidant. It's actually found in the skin of red grapes along with other nutrients, such as minerals manganese and potassium and vitamins K, C and B1.Stilbenoids are compounds produced by plants to fight infections, and in human biology appear to affect some of the signaling pathways that allow vitamin D to do its job, researchers said. It appears that combining these compounds with vitamin D has considerably more biological impact than any of them would separately. Fungus in humans identified for first time as key factor in Crohn's disease Case Western Reserve University, September 22, 2022 A Case Western Reserve University School of Medicine-led team of international researchers has for the first time identified a fungus as a key factor in the development of Crohn's disease. The researchers also linked a new bacterium to the previous bacteria associated with Crohn's. The groundbreaking findings, published in mBio, could lead to potential new treatments and ultimately, cures for the debilitating inflammatory bowel disease, which causes severe abdominal pain, diarrhea, weight loss, and fatigue. Mycology at Case Western Reserve and University Hospitals Cleveland Medical Center “Essentially, patients with Crohn's have abnormal immune responses to these bacteria, which inhabit the intestines of all people. While most researchers focus their investigations on these bacteria, few have examined the role of fungi, which are also present in everyone's intestines. Our study adds significant new information to understanding why some people develop Crohn's disease. Equally important, it can result in a new generation of treatments, including medications and probiotics, which hold the potential for making qualitative and quantitative differences in the lives of people suffering from Crohn's.” The researchers assessed the mycobiome and bacteriome of patients with Crohn's disease and their Crohn's-free first degree relatives in nine families in northern France and Belgium, and in Crohn's-free individuals from four families living in the same geographic area. Specifically, they analyzed fecal samples of 20 Crohn's and 28 Crohn's-free patients from nine families and of 21 Crohn's-free patients of four families. The researchers found strong fungal-bacterial interactions in those with Crohn's disease: two bacteria (Escherichia coli and Serratia marcescens) and one fungus (Candida tropicalis) moved in lock step. The presence of all three in the sick family members was significantly higher compared to their healthy relatives, suggesting that the bacteria and fungus interact in the intestines. Additionally, test-tube research by the Ghannoum-led team found that the three work together (with the E. coli cells fusing to the fungal cells and S. marcescens forming a bridge connecting the microbes) to produce a biofilm — a thin, slimy layer of microorganisms found in the body that adheres to, among other sites, a portion of the intestines — which can prompt inflammation that results in the symptoms of Crohn's disease. This is first time any fungus has been linked to Crohn's in humans; previously it was only found in mice with the disease. The study is also the first to include S. marcescens in the Crohn's-linked bacteriome. Additionally, the researchers found that the presence of beneficial bacteria was significantly lower in the Crohn's patients, corroborating previous research findings.
In this episode of The Stem Cell Report, sponsored by Bio-Techne, we will explore the modeling of complex human neuropsychiatric diseases such as autism, bipolar disorder, and others using stem cell-based, three-dimensional culture models of the brain and its development. Martin Pera will be joined by Drs. Carol Marchetto and Rusty Gage, experts in the normal and pathological development of the brain. Carol Marchetto is an Assistant Professor in the Anthropology Department at the University of California, San Diego and an adjunct Assistant Professor at the Salk Institute. Rusty Gage is the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease and the President of the Salk Institute for Biological Studies. He has received numerous awards and recognition for his research including his appointment as a Fellow of the National Academy of Medicine. He is a former president of the ISSCR and a current member of the Stem Cell Reports Editorial Board. HostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryTwitter: @martinperaJAXGuestsCarol Marchetto, PhD, University of California, San Diego, USA Rusty Gage, PhD, Salk Institute for Biological Studies, USA Supporting ContentReaching into the toolbox: Stem cell models to study neuropsychiatric disordersEthical, Legal, and Regulatory Issues Associated with Neural Chimeras and OrganoidsAbout Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @StemCellReportsAbout ISSCRWith nearly 4,500 members from more than 70 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCRAcknowledgementsISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Scientific AdvisorVoice WorkBen SnitkoffMusic@Konovalov
Videos: 1. The great recycling LIE (what really happens to plastic) (10:44) 2. Is It Game Over? New NASA Report (5:30) 2. You won't believe what Justin Trudeau's government just did | Redacted with Clayton Morris (13:26) 3. Neil Oliver – Who pulls the strings – Pandemic Treaty, Wealth & Power? (2:00) 4. He's EXPOSING the truth in Syria and they don't like it | Redacted conversation w/ Kevork Almassian (first 10:00) 5. Russian Ruble now best performing currency in the world this year… another example of how US sanctions have failed. 6. Vanessa Beeley and Eva Bartlett are smeared by the Guardian for reporting the truth (3:07) 7. Kim Iversen: Inside The SECRET Bilderberg Meetings Between Spies, War Hawks And World Leaders (9:28) 8. New Rule: The Misinformation Age | Real Time with Bill Maher (HBO) 9. https://theduran.locals.com/post/2311112/title 10. https://www.youtube.com/watch?v=3maIN4-ZJl8 Strawberry Compound Shown to Protect Against Alzheimer's, Memory Loss Salk Institute for Biological Studies, June 16, 2022 The thought of losing your mind is a frightening one, but one in three Americans die with Alzheimer's or some other form of dementia. Regardless how frightening the possibility is, the chances of it happening to you aren't exactly slim, which means prevention should be at the forefront of your mind. A recent study from the Salk Institute for Biological Studies indicates prevention could be as simple as a natural foods diet—rich in fruits (such as strawberries) and vegetables containing something called fisetin. Fisetin is a flavonol found in strawberries, mangoes, cucumbers, and other vegetables and fruits. Researchers with the Salk Institute found this simple compound can actually reduce the risk of Alzheimer's in mice, and could be effective in humans as well. Maher and her team have documented that fisetin has both anti-inflammatory and antioxidant properties in the brain. It is also able to turn on a cellular pathway related to memory function. The team looked to a type of mouse with mutated genes making them vulnerable to Alzheimer's. At three months old, the researchers began feeding the mice a diet enriched with fisetin. Mice who hadn't received the fisetin began struggling in the mazes at nine months of age, but the fisetin mice performed as well as normal (non-predisposed) mice at both nine and twelve months of age. Avocados may hold the answer to beating leukemia University of Waterloo (Canada), June 16, 2022 Rich, creamy, nutritious and now cancer fighting. New research reveals that molecules derived from avocados could be effective in treating a form of cancer. Professor Paul Spagnuolo from the University of Waterloo has discovered a lipid in avocados that combats acute myeloid leukemia (AML) by targeting the root of the disease – leukemia stem cells. Worldwide, there are few drug treatments available to patients that target leukemia stem cells. “The stem cell is really the cell that drives the disease,” said Professor Spagnuolo, in Waterloo's School of Pharmacy. “The stem cell is largely responsible for the disease developing and it's the reason why so many patients with leukemia relapse. We've performed many rounds of testing to determine how this new drug works at a molecular level and confirmed that it targets stem cells selectively, leaving healthy cells unharmed.” Inability to stand on one leg for 10 seconds in mid to later life linked to near doubling in risk of death Exercise Medicine Clinic-CLINIMEX (Brazil) and University of Eastern Finland, June 21, 2022 The inability to stand on one leg for 10 seconds in mid- to later life is linked to a near doubling in the risk of death from any cause within the next 10 years, finds research published online in the British Journal of Sports Medicine This simple and safe balance test could be included in routine health checks for older adults, say the researchers. The researchers wanted to find out whether a balance test might be a reliable indicator of a person's risk of death from any cause within the next decade, and, as such, might therefore merit inclusion in routine health checks in later life. Participants were asked to stand on one leg for 10 seconds without any additional support. To improve standardization of the test, participants were asked to place the front of the free foot on the back of the opposite lower leg, while keeping their arms by their sides and their gaze fixed straight ahead. Up to three attempts on either foot were permitted. In all, around 1 in 5 (20.5%; 348) participants failed to pass the test. The inability to do so rose in tandem with age, more or less doubling at subsequent 5 year intervals from the age of 51-55 onwards. The proportions of those unable to stand on one leg for 10 seconds were: nearly 5% among 51-55 year-olds; 8% among 56-60 year-olds; just under 18% among 61-65 year-olds; and just under 37% among 66-70 year-olds. More than half (around 54%) of those aged 71-75 were unable to complete the test. In other words, people in this age group were more than 11 times as likely to fail the test as those just 20 years younger. During an average monitoring period of 7 years, 123 (7%) people died: cancer (32%); cardiovascular disease (30%); respiratory disease (9%); and COVID-19 complications (7%). The proportion of deaths among those who failed the test was significantly higher: 17.5% vs. 4.5%, reflecting an absolute difference of just under 13%. Anxious Children have Bigger “Fear Centers” in the Brain Stanford University School of Medicine, June 16, 2022 The amygdala is a key “fear center” in the brain. Alterations in the development of the amygdala during childhood may have an important influence on the development of anxiety problems, reports a new study in the current issue of Biological Psychiatry. Researchers at the Stanford University School of Medicine recruited 76 children, 7 to 9 years of age, a period when anxiety-related traits and symptoms can first be reliably identified. The researchers found that children with high levels of anxiety had enlarged amygdala volume and increased connectivity with other brain regions responsible for attention, emotion perception, and regulation, compared to children with low levels of anxiety. They also developed an equation that reliably predicted the children's anxiety level from the MRI measurements of amygdala volume and amygdala functional connectivity. The most affected region was the basolateral portion of the amygdala, a subregion of the amygdala implicated in fear learning and the processing of emotion-related information. Our study represents an important step in characterizing altered brain systems and developing predictive biomarkers in the identification for young children at risk for anxiety disorders,” Qin said. New research: Olive oil compound destroys cancer cells in 30 minutes Rutgers University & Hunter College, June 12, 2022 Oleocanthal, a polyphenolic, therapeutic compound found in olive oil is the subject of a new anti-cancer study performed by nutritional science and cancer biology researchers with The School of Environmental and Biological Sciences at Rutgers and Hunter's College in New York City. Programmed cell death, known as apoptosis takes approximately 16-24 hours. Dynamic new research just published in the Journal of Molecular and Cellular Oncology blew scientists away – when exposed to oleocanthal, a polyphenol compound found in olive oil, cancerous cells died within 30 minutes to an hour. While researchers previously understood that compounds in olive oil were capable of killing cancer cells, until now, such short apoptosis had not been observed. Even more fascinating was when the team looked closely to surmise why apoptosis was occurring under such swift circumstances – they discovered that cancer cells were being killed by their own enzymes. And, not only one isolated type of cancerous cell, but all of the cancerous cells they were examining. Unlike chemotherapeutic pharmaceuticals that devastate healthy cellular activity, the therapeutic polyphenolic compound found in olive oil kills cancer while maintaining vitality among healthy cells. As Paul Breslin, one of the study's authors at Rutgers noted, while cancerous cells died, healthy cells were not harmed, but rather the oleocanthal “put them to sleep.” The lifecycle of healthy cells was only temporarily affected in this way, without any negative observations and in approximately 24 hours, the healthy cells resumed their life cycle. Sports, not screens: The key to happier, healthier children University of South Australia, June 21, 2022 Whether it's sports practice, music lessons or a casual catch up with friends, when children are involved in after-school activities, they're more likely to feel happier and healthier than their counterparts who are glued to a screen. In a new study conducted by the University of South Australia, researchers found that children's well-being is heightened when they participate in extra-curricular activities, yet lowered when they spent time on social media or playing video games. Published in BMC Pediatrics, the study analyzed data from 61,759 school students in years 4 to 9, assessing the average number of days per week children participated in after-school activities (3–6pm), and measure these against well-being factors—happiness, sadness, worry, engagement, perseverance, optimism, emotion regulation, and life satisfaction. It found that most students watched TV about four days of the school week and spent time on social media about three days of the week. Our study highlights how some out-of-school activities can boost children's well-being, while others—particularly screens—can chip away at their mental and physical health. “Screens are a massive distraction for children of all ages. And whether children are gaming, watching TV or on social media, there's something about all screens that's damaging to their well-being. Students in lower socio-economic backgrounds who frequently played sports were 15% more likely to be optimistic, 14% more likely to be happy and satisfied with their life, and 10% more likely to be able to regulate their emotions. Conversely, children who played video games and used social media almost always had lower levels of well-being: up to 9% less likely to be happy, up to 8% to be less optimism and 11% to be more likely to give up on things.
The third Season of the National Institute of Neurological Disorders and Stroke's Building Up the Nerve podcast helps you strengthen your mentoring relationships with tools and advice from both trainees and faculty. We know that navigating your career can be daunting, but we're here to help—it's our job!In the third episode of the season, we are talking with mentor mentee pairs about how they develop productive relationships, including aligning their expectations and working through challenges. Featuring Avital Rodal, PhD - Associate Professor of Biology, Brandeis University; Matthew Pescosolido, PhD – Postdoctoral Fellow, Brandeis University; Kay Tye, PhD – Professor, Salk Institute for Biological Studies; and Austin Coley, PhD - Postdoctoral Associate, Salk Institute for Biological Studies.ResourcesResources and examples for writing a lab manual:“How to…write a lab handbook” from The Biologist: https://thebiologist.rsb.org.uk/biologist-features/how-to-write-a-lab-handbookLab Manual Resources from OSF: https://osf.io/2xn6z/wiki/Other%20lab%20manual%20resources/“Redesigning our lab practices” by Ari Benjamin: http://kordinglab.com/2019/12/20/lab-redesign.htmlDr. Rodal's Lab Manual: https://docs.google.com/document/d/1gUtWSk7CqV3syAenEc11rnz4H5-yvU65b48NM46n-Vs/editmyIDP ScienceCareers for drafting an Individual Development Plan: https://myidp.sciencecareers.org/ Center for the Improvement of Mentored Experiences in Research (CIMER) has numerous FREE resources for mentors and mentees, including creating a mentoring compact (login required): https://cimerproject.org/ Season 2 of Building Up the Nerve takes you through the components of a grant application with successful awardees: https://ninds.buzzsprout.com/ Transcript available at http://ninds.buzzsprout.com/.
For March 4, 2022: 1. Local startup connects users with favorite athletes, sports personalities 2. Salk Professor Martyn Goulding wins Brain Prize - Salk Institute for Biological Studies 3. Beer battles: Stone Brewing's trademark fight with Keystone finally heads to trial 4. SD County to divest of fossil fuels 5. General Atomics and Orion Space win contract for military weather satellites
Story Topic #1: Fast-food nation: 1 in 5 parents says kids eating more junk since pandemic began https://www.studyfinds.org/fast-food-nation-children-eat-more-junk-pandemic/ Eating at home more frequently as a result of COVID-19 restrictions and concerns might lead one to believe children are eating healthier, but new research challenges that conclusion. According to a survey, one in five parents say their kids have been snacking away on more junk food since the start of the pandemic. Although many moms and dads say their family has enjoyed healthier meals since the onset of coronavirus, 20% admit being “too stressed” to cook. And one in six say their child consumes fast-food at least twice a week. The survey of more than 2,000 parents of American children aged 3 to 18 was conducted by researchers at the University of Michigan Health C.S. Mott Children's Hospital. While almost all parents agreed that fast food is unhealthy for their children, more than 80% feel it's “okay” in moderation, according to the poll. Three out of four parents also agreed with the statement that when stressed for time, fast-food is a good family option. A third of parents say that fast-food is good value for the money, while almost 24% feel it is less expensive than making meals at home. Children health study “Parents mostly acknowledge that fast-food isn't an ideal choice, but see it as an acceptable ‘sometimes food.' But parents don't usually dictate their kids' food choices at fast-food restaurants, with 88% allowing their child to choose what they eat and only one in three parents reading the nutritional information,” says Dr. Freed. However, two out of three parents (67%) say they encourage their children to choose healthier options and try to limit unhealthy items such as chips and milkshakes. “One fast-food meal often exceeds the recommended fat, sodium, and calorie intake for the entire day without providing many nutrients. Parents should consider using nutritional information to help their kids learn how to make healthier choices. Trying to make those meals even a little bit healthier can have an important impact,” adds Dr. Freed. ----> Christine's take on the story ------------ Story Topic #2: Intermittent fasting improves sleep quality, helps manage diabetes, heart disease https://www.studyfinds.org/intermittent-fasting-diabetes/ Intermittent fasting has become wildly popular among the dieting community over the last decade. Now, a new study is adding more fuel to that fire after researchers discovered the weight loss trend may help people better manage conditions such as diabetes and heart disease. Researchers also find that intermittent fasting also helps overall sleep quality. The authors say a time-restricted diet, where you eat your daily calories within an eight to ten-hour window, is a powerful tool in managing metabolic diseases. For people dealing with blood sugar issues, cholesterol trouble, and heart problems, losing weight is a key part of preventing serious health complications. “People who are trying to lose weight and live a healthier lifestyle should pay more attention to when they eat as well as what they eat. Time-restricted eating is an easy-to-follow and effective dietary strategy that requires less mental math than counting calories,” says Satchidananda Panda, Ph.D., from the Salk Institute for Biological Studies in a media release. “Intermittent fasting can improve sleep and a person's quality of life as well as reduce the risk of obesity, diabetes and heart disease.” Panda's team found that the expression of genes, hormone levels, and a person's metabolism rises and falls during different times of the 24-hour day. By aligning our eating schedules with the body's internal clock, the study finds patients with metabolic issues can reduce the health burden of several chronic diseases. “Eating at random times breaks the synchrony of our internal program and make us prone to diseases,” Panda explains. “Intermittent fasting is a lifestyle that anyone can adopt. It can help eliminate health disparities and lets everyone live a healthy and fulfilling life.” Previous studies have found that intermittent fasting also helps to reshape a person's gut microbiome and even improves memory. ----> Christine's take on the story ------------------ MAIN (from Christine's youtube channel) Story Topic #3: What Are Signs Of Insulin Resistance And How Can You Reverse It? 1. Hemoglobin A1c test The best way to determine whether or not someone has insulin resistance conclusively is to get your hemoglobin A1c tested. Just keep in mind, that when you get your A1c levels tested, it's an average of what's going on in your blood in the last thirty days. If your A1c levels are under 5.7, you are fine. Between 5.7 and I'd say about 6.4 is pre-diabetic. I'd say over 6.4 is diabetic. 2. Your fasting blood glucose If your fasting blood glucose is over 100, that's also an indicator. But outside of the actual numbers, if you eat carbohydrates, and when you eat carbohydrates, you still feel hungry afterwards, and you feel like once the hunger switch is turned on, it does not go off, this is a very good sign that you have insulin resistance. And the reason why is because when you consume carbohydrates, it causes your blood sugar to go up. When your blood sugar goes up, what needs to happen is insulin is a messenger hormone, which is required to shuttle the glucose out of the blood and into the cells. However, some individuals do not have... that process doesn't go smooth for them. So, what that means is insulin is grabbing onto the glucose molecule, knocking on the door of yourself and trying to escort it inside. And what ends up happening is the cells are non-responsive. They're not answering the door. It's like they don't have a secret knock. And when that happens, the pancreas creates more insulin and more insulin and more insulin. We're trying to barge down the doors of these cells to get the glucose out of the bugs. It's a toxic system, a toxic state to have high blood sugar. So, when all of that occurs, you're starving on the cellular level, because we think of the food we consume, we think the end user of food is what? The stomach. No, the end user of that food is your cells. So, your cells still have not received energy, even though you are eating. So, if the cells are not receiving energy, they can't send the signal to the brain to tell you that you're full. So, you're going to keep eating and eating and eating, and it's just a recipe for disaster. Brain fog, just tired, hungry all the time - just crazy cravings. How to reverse insulin resistance The only way to really get in front of it and intercede it is to break that cycle. And it's going to be hard at first, because a lot of people have to go through a sugar detox process, or they really need to start fueling their body off of healthy fats for fuel instead of carbs. But it can be treated with proper nutrition. I see people reverse out of the diabetic and pre-diabetic state using nutrition alone. ********** Sign up for Gauge Life podcast updates here! https://gaugegirltraining.com/pages/lifeline-podcast-opt-in Follow Christine on Social Media IG: https://www.instagram.com/gaugegirltr... FB: https://www.facebook.com/gaugegirl/ PINTEREST: https://www.pinterest.com/gaugegirl82... YOUTUBE: https://www.youtube.com/channel/UC1Ey... Free Macros Blueprint Download: https://bit.ly/35zB6OU Gauge Girl Training Website: https://gaugegirltraining.com/ About Christine Hronec Christine Hronec ( https://gaugelife.com ) is an award-winning chemist and three-time champion fitness competitor, nutrition, and exercise expert. Since founding her company Gauge Life in 2013, Christine has helped approximately 40,000 women transform their bodies and switch to a body-positive self-image. Her YouTube channel has over 25 million views. Christine has received awards from the American Chemical Society and was published in the American Institute of Chemical Engineers. Christine was part of the team that created Time magazine's “Invention of the Year” for her work in the biotech field.
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