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BacterioFiles
447: Big Bacteria Bank Behaviors

BacterioFiles

Play Episode Listen Later Feb 8, 2021 12:41


This episode: Giant bacteria with many chromosomes in each cell carry extra genes to help them live in many different environments! Download Episode (8.7 MB, 12.7 minutes) Show notes: Microbe of the episode: Propionibacterium virus SKKY News item   Takeaways We think of bacteria a certain way: too small to see and having mostly just a single large chromosome with all the genes they need for their lifestyle and not much more. And most bacteria are like that. But not all! Giant bacteria exist, some of which can be so large that individual cells can be seen without a microscope.   Achromatium species are one such kind of bacteria. They form clumps of minerals that take up most of their internal volume, but their cells are big enough to see and handle. In order to supply all parts of their vast innards with proteins, they have many copies of their chromosome distributed throughout their cytoplasm.   In this study, a survey of Achromatium genomes from all different kinds of ecosystem revealed that even different species in very different environments all seem to share one set of genetic functions, but only use the ones they need for their particular lifestyle while archiving the rest.   Journal Paper: Ionescu D, Zoccarato L, Zaduryan A, Schorn S, Bizic M, Pinnow S, Cypionka H, Grossart H-P. Heterozygous, Polyploid, Giant Bacterium, Achromatium, Possesses an Identical Functional Inventory Worldwide across Drastically Different Ecosystems. Mol Biol Evol https://doi.org/10.1093/molbev/msaa273. Other interesting stories: As with other infections, gut microbiota correlates with severity of COVID-19 Fungi help plants defend against aphids   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Heroes Three · Adventures in Asian Cinema

 Welcome back to Heroes Three Podcast! It's 2021 and we FINALLY found Marty. In this chill, welcome back episode we talk about the podcast itself, where we've been and where we're going. Remember your training! Download Episode here!

BacterioFiles
446: Biofilm Benefits Bone Braces

BacterioFiles

Play Episode Listen Later Feb 1, 2021 7:56


This episode: The biofilm that probiotic bacteria can leave behind on a titanium implant seems to help it integrate better with the existing skeleton, with less inflammation and risk of infection! Download Episode (5.5 MB, 7.9 minutes) Show notes: Microbe of the episode: Methylobacterium organophilum News item   Takeaways Skeletal implants make it a lot easier for many people to stay mobile as they age, but the surgical procedure of implanting is risky. Its invasive nature puts stress on the immune system, which puts stress on other systems, and the spread of antibiotic resistance is increasing the risk of a hard-to-treat infection.   In this study, probiotic bacteria grow in a biofilm on titanium implants before being inactivated, leaving only the biofilm behind on the implant. This biofilm-coated implant showed improved bone integration, antimicrobial resistance that was not toxic to the body's own tissues, and reduced inflammation when implanted into rats.   Journal Paper: Tan L, Fu J, Feng F, Liu X, Cui Z, Li B, Han Y, Zheng Y, Yeung KWK, Li Z, Zhu S, Liang Y, Feng X, Wang X, Wu S. 2020. Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection. Sci Adv 6:eaba5723. Other interesting stories: Certain gut microbes correlate with lower risk from norovirus (paper) Mixture of microbes similar to kombucha engineered to produce living functional materials   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
445: Living Lurking Landmine Locators

BacterioFiles

Play Episode Listen Later Jan 25, 2021 9:21


This episode: Engineered bacteria encapsulated in little beads sense chemicals from landmines and give off light! Download Episode (6.4 MB, 9.3 minutes) Show notes: Microbe of the episode: Bifidobacterium pullorum Takeaways Landmines are a good way to take an enemy by surprise and do some damage. They're so good that some places in the world still aren't safe to go decades after a conflict, due to intact landmines hidden in the area. In order to detect them from a distance to aid in disarming efforts, we need something very good at detecting the faint odor they give off—something like bacteria!   In this study, bacteria are engineered to detect breakdown products of TNT in landmines and produce light—bioluminescence. These bacteria are encapsulated in polymer beads and are stable for months in the freezer, and could accurately pinpoint a landmine buried in sand for a year and a half.   Journal Paper: Shemer B, Shpigel E, Hazan C, Kabessa Y, Agranat AJ, Belkin S. Detection of buried explosives with immobilized bacterial bioreporters. Microb Biotechnol https://doi.org/10.1111/1751-7915.13683. Other interesting stories: Wastewater treatment plant could power itself from electricity produced by microbes Microbial exposures correlate with presence or lack of allergies in both people and their dogs   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
444: Strange Sequence Stops Cell Subjugation

BacterioFiles

Play Episode Listen Later Jan 18, 2021 10:20


This episode: An interesting bacterial genetic element protects against viruses in a unique way! Download Episode (7.1 MB, 10.3 minutes) Show notes: Microbe of the episode: Mongoose associated gemykibivirus 1 News item Takeaways Even single-celled, microscopic organisms such as bacteria have to deal with deadly viruses infecting them. And while they don't have an immune system with antibodies and macrophages like we do, they still have defenses against infection, mostly based on sensing and destroying viral genomes. Restriction enzymes cut viral genomes at specific places, and CRISPR/Cas targets and destroys specific viral sequences. Knowing this, when microbiologists contemplate a strange genetic element of unknown function in bacteria, it's worth considering that it may be relevant to defense against phages.   The strange element in this case is retrons: a special reverse transcriptase enzyme takes a short non-coding RNA transcript and transcribes it into DNA, then links the RNA and DNA sequences together. These retrons are found in a variety of forms in a variety of microbes, and their function has been unknown up till now. In this study, one specific retron was found to defend bacteria against a number of phages. By comparing viruses, they discovered that this retron functions by sensing viruses' attempts to defeat another bacterial defense, a sort of second level of defenses. How common such a system is, what variants may exist, and how we may be able to use it for research or biotech purposes remain to be determined.   Journal Paper: >Millman A, Bernheim A, Stokar-Avihail A, Fedorenko T, Voichek M, Leavitt A, Oppenheimer-Shaanan Y, Sorek R. 2020. Bacterial Retrons Function In Anti-Phage Defense. Cell 183:1551-1561.e12. Other interesting stories: Bacteria can make biodegradable plastics from waste sludge   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
443: Gut Group Gives Gamma Guard

BacterioFiles

Play Episode Listen Later Jan 11, 2021 10:39


This episode: Certain gut microbes protect mice from harmful effects of high-energy radiation! Download Episode (7.3 MB, 10.6 minutes) Show notes: Microbe of the episode: Solenopsis invicta virus-1 News item Takeaways High-energy radiation can be very dangerous. Besides a long-term increased risk of cancer due to DNA damage, a high enough dose of radiation can cause lethal damage to multiple systems in the body, especially the gastrointestinal tract and the immune system. Finding new ways to treat or prevent damage from radiation would be very helpful for improving the safety of space travel, nuclear energy, and radiotherapy for cancer.   In this study, some mice exposed to a typically lethal dose of radiation survived without ill effects, thanks to certain microbes in their gut. Transferring these microbes to other mice helped those mice survive radiation as well, and even just the metabolites that the bacteria produced were helpful for protecting the cells in the body most affected by radiation.   Journal Paper: Guo H, Chou W-C, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. 2020. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science 370:eaay9097. Other interesting stories: Algae incorporated into 3D-printed human tissues for research can provide oxygen for cells Bacteria in sea squirts produce potentially useful antifungal compound   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
442: Fossil Phototroph Phagocytosis

BacterioFiles

Play Episode Listen Later Dec 28, 2020 10:16


This episode: Algae surviving impact that killed the dinosaurs seem to have consumed other organisms to make it through the dark times! Download Episode (7.1 MB, 10.3 minutes) Show notes: Microbe of the episode: Chaetoceros tenuissimus RNA virus 01 News item Takeaways Being able to look through time and learn about what might have happened to creatures throughout Earth's history is what makes paleontology great. Everyone knows about dinosaurs and what happened to them at the end of the Cretaceous period thanks to science. But what we can learn is not limited just to large organisms; there are ways to learn about microorganisms of the past as well, including by looking at fossils!   In this study, fossils of hard-shelled algae from around the end of the dinosaurs show that many of these microbes in the oceans went extinct at the same time due to the massive space impact. Debris blocked out sunlight for years, making it difficult for photosynthetic organisms to survive. So some of these algae appear to have survived by preying on smaller organisms, pulling them in through a hole in their shell.   Journal Paper: Gibbs SJ, Bown PR, Ward BA, Alvarez SA, Kim H, Archontikis OA, Sauterey B, Poulton AJ, Wilson J, Ridgwell A. 2020. Algal plankton turn to hunting to survive and recover from end-Cretaceous impact darkness. Sci Adv 6:eabc9123. Other interesting stories: Phages could help treat diabetic wound infections without harming microbiota (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
441: Hyphal Hijacker Helps Harvests

BacterioFiles

Play Episode Listen Later Dec 21, 2020 8:52


This episode: A fungus-infecting virus transforms the fungal foe into a friend of its host plant! Download Episode (6.1 MB, 8.9 minutes) Show notes: Microbe of the episode: Hepacivirus J   News item Takeaways Viruses can be useful for treating various diseases, especially bacterial infections and cancer. Their ability to target certain cell types specifically makes them great at hunting down and killing disease-causing cells without harming the body's healthy tissue. And just as bacteriophages can work to treat bacterial disease in us, fungal viruses could help to treat serious fungal infections in crop plants.   In this study, a fungus-infecting virus goes beyond treating a deadly fungal disease in rapeseed plants. Fungus infected with this virus no longer causes disease, but lives in harmony with the host plant, protects it from other fungal diseases, and even helps it to grow better.   Journal Paper: Zhang H, Xie J, Fu Y, Cheng J, Qu Z, Zhao Z, Cheng S, Chen T, Li B, Wang Q, Liu X, Tian B, Collinge DB, Jiang D. 2020. A 2-kb Mycovirus Converts a Pathogenic Fungus into a Beneficial Endophyte for Brassica Protection and Yield Enhancement. Mol Plant 13:1420–1433. Other interesting stories: Engineering E. coli to turn carbon dioxide into biomass Radiation super-resistant bacteria survive 1 year exposed to low Earth orbit   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Atheist Nomads
Episode 385 - Methodist Schism Begins

Atheist Nomads

Play Episode Listen Later Dec 17, 2020 50:17


This week we talk about Hanukkah, the start of the Methodist schism, Bundy’s protests getting scarier, and more. Announcements War on Christmas live stream December 20 2:00 PM MST Email us at contact@atheistnomads.com or leave us a voice message using atheistnomads.com/speakpipe Support the show at atheistnomads.com/donate Subscribe at atheistnomads.com/subscribe Join our Discord server at atheistnomads.com/discord Dustin’ Off The Degree Hanukkah News Progressive United Methodists announce new denomination: Liberation Methodist Connexion Citing rise of ‘Christian nationalism,’ Secular Democrats unveil sweeping recommendations for Biden Supreme Court Declines to Hear Box v. Henderson Hungary bans same-sex couples from adopting children Bundy group, People’s Rights, training to defend from government ‘force’ Health order fails on 3-3 vote; Elmore, Boise, Valley County vote against More people are willing to get a COVID vaccine now than they were two months earlier. Let’s hope that willingness level gets high enough by the time the vaccines are available for the general public $1,500 payment proposed for people who get COVID-19 vaccine Faith Leaders Condemn OK Gov. for Responding to COVID with “Prayer and Fasting” Contact JaeLyne via Facebook Support This episode is brought to you by: Henry K Danielle M Pat Acks from the Humanists of Idaho SoJo Beatriz A Zoe Darryl G Arthur K Samuel Erik from Wyoming Jennifer N Erica B Richard G Balázs Rebecca P And by our $1 patrons and those who want no reward. You can find us online at www.atheistnomads.com, follow us on Twitter @AtheistNomads, like us on Facebook, email us at contact@atheistnomads.com, and leave us a voice message using SpeakPipe. Theme music is provided by Sturdy Fred. DOWNLOAD EPISODE link is probably at the top of the page

BacterioFiles
440: Prokaryotes Pay for Passage

BacterioFiles

Play Episode Listen Later Dec 14, 2020 11:13


This episode: Bacteria pay for the privilege of cruising around soil on fungus filaments! Download Episode (7.7 MB, 11.2 minutes) Show notes: Microbe of the episode: Clostridium acetobutylicum News item Takeaways In the complex environment of soil, many different kinds of organisms coexist. Some compete with each other, while others cooperate in fascinating interactions. One example is how bacteria can swim through a film of water surrounding the filaments of fungi, allowing them to traverse more quickly and reach new locations.   In this study, an interaction between fungus and bacterium is discovered in which the bacteria benefit from the fungus in enhanced ability to travel, and the fungus benefits by absorbing vitamins that the bacteria produce.   Journal Paper: Abeysinghe G, Kuchira M, Kudo G, Masuo S, Ninomiya A, Takahashi K, Utada AS, Hagiwara D, Nomura N, Takaya N, Obana N, Takeshita N. 2020. Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism. Life Sci Alliance 3(12):202000878. Other interesting stories: Honeybee gut microbes help them define their social groupings Smells that cheese fungi make help cheese microbe community develop Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Zombie Take-Out: The b-movie and cult movie podcast
Zombie Take-Out Episode 431: Grail-Shaped Movie

Zombie Take-Out: The b-movie and cult movie podcast

Play Episode Listen Later Dec 10, 2020


John and Scotto pay tribute to the late great David Prowse with their review of Jabberwocky. John's Ratings Scotto's Ratings Listen to Episode 431 Download Episode 431 News Warner Bros. Will Release Its Films on HBO Max and in Theaters Simultaneously. The Decision May Change Moviegoing Forever IMDb https://www.imdb.com/title/tt0076221/ Trailer Next Time ... Santa Jaws

SQUAWKING DEAD
[Episode 117] The Walking Dead: World Beyond |Season One| Season Finale

SQUAWKING DEAD

Play Episode Listen Later Dec 2, 2020 133:21


I still don't know how we did it, but we managed to break down the more than 2-hour Season Finale of TWDWB's 1st season, episode 1x09 & 1x10 ("The Deepest Cut" & "In This Life", respectively) in just over 2 hours! We take a REALLY close look at Huck's actions throughout the season, ALL of our characters' rapid growth (in particular our designated #MVP, #EltonOrtiz), and what direction our characters seem to be heading by the end of it. GET THE UNEDITED VERSION OF THIS EPISODE -AND- lend your voice in our next recording session, all while supporting our podcast? Well, click here! https://ko-fi.com/post/DOWNLOAD-Episode-116-Unedited-Episode-Recording-L3L62U7X2 --- Send in a voice message: https://anchor.fm/squawkingdead/message

BacterioFiles
439: Microbes Mitigate Mushroom Morbidity

BacterioFiles

Play Episode Listen Later Nov 30, 2020 7:08


This episode: Bacteria protect farmed mushrooms from damage by other bacteria by breaking down their toxins! Download Episode (4.9 MB, 7.1 minutes) Show notes: Microbe of the episode: Tomato mosaic virus Takeaways Almost all organisms are vulnerable to pathogenic microbes that make them sick or cause damage. Most also have other microbes that help them grow better or protect them from pathogens. This includes animals, plants, and also fungi. In this study, bacterial pathogens produce a toxin that causes button mushrooms to turn brown and rot. However, other bacteria can degrade this toxin and protect the fungus, and can also degrade molecules the pathogens produce to help them swarm to new places, restricting their movement. Journal Paper: Hermenau R, Kugel S, Komor AJ, Hertweck C. 2020. Helper bacteria halt and disarm mushroom pathogens by linearizing structurally diverse cyclolipopeptides. Proc Natl Acad Sci 117:23802–23806. Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
438: Bacteria Bait Bug Babies

BacterioFiles

Play Episode Listen Later Nov 16, 2020 8:16


This episode: Actinomycete bacteria are often helpful to insects, but some can be deadly yet still attractive! Download Episode (5.7 MB, 8.3 minutes) Show notes: Microbe of the episode: Streptomyces corchorusii   News item Takeaways Actinomycete bacteria do a lot of interesting things. They grow like fungi, with mycelia and spores, and produce many interesting compounds, including antibiotics and other useful pharmaceuticals. They often team up with insects, producing such compounds to assist them in competing with other organisms or resisting disease.   But such amazingly helpful powers of chemistry can also be amazingly harmful. In this study, multiple strains of these bacteria were able to kill fruit fly larvae that ingested their spores. The toxin the bacteria produced was a chemical that interferes with cells' DNA-protein interactions. The bacteria also produced an odor that, in certain concentrations, lured the larvae to their doom. Journal Paper: Ho LK, Daniel-Ivad M, Jeedigunta SP, Li J, Iliadi KG, Boulianne GL, Hurd TR, Smibert CA, Nodwell JR. 2020. Chemical entrapment and killing of insects by bacteria. Nat Commun 11:4608. Other interesting stories: Eukaryotes borrowed viperin genes for proteins that prokaryotes use to fight viruses (paper) Bacteria can break down plastic even faster with newly discovered enzyme Also news, Feedspot ranked BacterioFiles in the top 5 virology podcasts! Check out the list for other good shows about viruses.   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
437: Balmy Bacteria Build Bone

BacterioFiles

Play Episode Listen Later Nov 9, 2020 9:51


This episode: Warmth helps mice build stronger bones, mediated by bacteria producing certain compounds! Download Episode (6.8 MB, 9.9 minutes) Show notes: Microbe of the episode: Aquaspirillum serpens   News item Takeaways Bones aren't just solid, structural supports for the body's tissues. They're active and alive, housing important components of the immune system, and also capable of being broken down and built up in response to changes in the body's interactions with the environment. Various things can affect bone mass and health, including nutrition, temperature, age, and even the body's microbes.   In this study, two of these effects are found to interact. Warmth leads to increased bone density in mice, and this effect can be attributed to the microbes in the mice, and transmitted from one mouse to another just by transplanting microbes adapted to warmth. Even the particular chemicals the microbes produce that mediate this effect are discovered. Journal Paper: Chevalier C, Kieser S, Çolakoğlu M, Hadadi N, Brun J, Rigo D, Suárez-Zamorano N, Spiljar M, Fabbiano S, Busse B, Ivanišević J, Macpherson A, Bonnet N, Trajkovski M. 2020. Warmth Prevents Bone Loss Through the Gut Microbiota. Cell Metab 32:575-590.e7. Other interesting stories: Salt-tolerant bacteria could help plants grow in coastal areas (paper) Fire ants like to nest near potentially antifungal bacteria   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Art Lives
Season 3 - Episode 2: Li-Hsuan Hsu

Art Lives

Play Episode Listen Later Nov 3, 2020


Download Episode 3:2 Transcript Li-Hsuan Hsu is an art educator and researcher whose interests lie at the intersection of arts and leadership.In this episode, Li-Hsuan tells us how she uses art to teach students leadership and coping skills for difficult times. She also speaks about how the practice of making art can create a space to pause, recalibrate, and process our emotions. Some of Li-Hsuan’s recent research can be found here.Some recent artwork can be found here. Art Lives Podcast RSS Art Lives Theme and Incidental music composed by Nicholaus Meyers, and performed by Nicholaus and Ken Jimenez. Art Lives Logo created by Eduardo Moreno. Art Lives is available here, Apple Podcasts and Stitcher.

BacterioFiles
436: Copper Concentrates Culture Current

BacterioFiles

Play Episode Listen Later Oct 26, 2020 7:14


This episode: Copper electrodes, rather than killing bacteria in microbial fuel cells, allow them to generate higher densities of electric current! Download Episode (5.0 MB, 7.2 minutes) Show notes: Microbe of the episode: Xipapillomavirus 2   News item Takeaways Copper is widely used as a way to make surfaces and materials antimicrobial, to cut down on the spread of pathogens in hospitals and other environments. Among other mechanisms, it reacts with oxygen to form reactive oxygen species that are very harsh on microbial proteins. But copper is also a good electrical conductor, which would be useful to use in microbial fuel cells, which exploit bacterial metabolism to generate electricity. Microbes form biofilms on an electrode and transfer electrons to it as a way for them to generate energy. Most such fuel cells have used graphite electrodes to avoid toxicity.   In this study, fuel cell bacteria grew well on a copper electrode in an oxygen-free environment. The copper actually allowed them to increase the amount of current they produced per unit of area, as ionic copper diffused through the biofilm and allowed electrons to flow through the biofilm to the electrode from layers farther from the electrode that otherwise would not have access. Even graphite electrodes could be improved by adding these copper ions to the biofilm directly. Journal Paper: Beuth L, Pfeiffer CP, Schröder U. 2020. Copper-bottomed: electrochemically active bacteria exploit conductive sulphide networks for enhanced electrogeneity. Energy Environ Sci 13:3102–3109. Other interesting stories: Lizard gut microbes are affected by temperature, and may affect lizard heat tolerance (paper) Phages in ice show evidence of trading genes easily to adapt to new environments   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
435: Invader Introducing Infrared Invokes Immunity

BacterioFiles

Play Episode Listen Later Oct 19, 2020 11:52


This episode: Combining Salmonella with something called photoimmunotherapy to attack tumors in multiple ways! Download Episode (8.2 MB, 11.9 minutes) Show notes: Microbe of the episode: Shimwellia blattae Takeaways Distinguishing healthy from unhealthy tissue is one of the big challenges when dealing with cancer. Since cancer is derived from healthy tissue, there are many similarities between them that make it hard to target it specifically. This is especially important when cancer is spread in multiple places throughout the body, as opposed to a single tumor that can be removed locally.   In this study, bacteria modified to make them safer were injected into mice with tumors. The bacteria alone were capable of doing some damage to the tumors, and this damage happened to make the tumors darker. Using this color change, the scientists targeted the tumors with lasers to heat them up and kill them in an isolated manner. This had the added benefit of inducing an immune response against the cancer that could target it throughout the body. Journal Paper: Yi X, Zhou H, Chao Y, Xiong S, Zhong J, Chai Z, Yang K, Liu Z. 2020. Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer. Science Advances 6:eaba3546. Other interesting stories: Bacteria could help make nylon more sustainably Glowing bacteria living in nematodes that kill insects may also interact with and protect plant roots (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
434: Killer Carries Compact Cas

BacterioFiles

Play Episode Listen Later Sep 28, 2020 8:36


This episode: Large phage discovered that contains a compact version of the CRISPR/Cas defense/gene editing system! Download Episode (5.9 MB, 8.6 minutes) Show notes: Microbe of the episode: Stenotrophomonas virus IME13 News item Takeaways CRISPR/Cas systems have made a lot of things in gene editing much easier in certain organisms. It's almost as easy as just getting the cells to produce the Cas protein and putting in an RNA sequence to tell it where to go! But in some cases, these requirements are too much to work well.   In this study, a more compact version of CRISPR/Cas was discovered in large bacteriophages. These systems help the viruses compete with other viruses and defend against host defenses sometimes. The Cas protein is half the size of the standard Cas most used in gene editing, and it has fewer other requirements to function in new cells, so it could be better in versatility and potential in applications with strict space constraints. Journal Paper: Pausch P, Al-Shayeb B, Bisom-Rapp E, Tsuchida CA, Li Z, Cress BF, Knott GJ, Jacobsen SE, Banfield JF, Doudna JA. 2020. CRISPR-CasΦ from huge phages is a hypercompact genome editor. Science 369:333–337. Other interesting stories: Example of how cooperation becomes more beneficial than independence Programming bacteria to detect and kill specific other microbes in a mixed community (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Heroes Three · Adventures in Asian Cinema
Episode 72: My Young Auntie (1981)

Heroes Three · Adventures in Asian Cinema

Play Episode Listen Later Sep 23, 2020


Welcome to episode 72 of Heroes Three! This week we talk about the the antics and action of Lau Kar Leung's 1981 film My Young Auntie starring Kara Hui in her first leading role!Check us out on social media - Twitter Instagram Facebook EmailGrab your favorite H3 GIFs here - Heroes Three Giphy Heroes Three gfycatCheck out some art from the show by Carlos  - Kung Fu Carlito on TeepublicFull film credits at HKMDBDownload EpisodeMusic featured in My Young Auntie

BacterioFiles
433: Probiotic Promotes Pathogen Peacefulness

BacterioFiles

Play Episode Listen Later Sep 21, 2020 10:05


This episode: A probiotic can protect intestine-like cell growths from destruction by pathogens, but it can also be infected by a virus that makes it more harmful to intestinal cells! Download Episode (6.9 MB, 10.1 minutes) Show notes: Microbe of the episode: Euphorbia yellow mosaic virus   News item Takeaways There are many strains of Escherichia coli. Some are pathogenic, in the gut or the urinary tract, and a subset of those are very dangerous, such as the enterohemorrhagic O157:H7 strain. Many others are commensals, living peacefully as part of our gut community. And some strains can be beneficial to the host, protecting from and reducing the severity of disease. One such strain is called E. coli Nissle.   This study used an advanced model of human intestines called organoids, where stem cells are induced to develop into hollow spheres of intestinal epithelium in which all cell types of a normal intestinal wall are represented. E. coli pathogens typically destroy these organoids and escape from inside, but Nissle was able to prevent this destruction and enable coexistence between the pathogen and the host cells. Nissle suffered for this protection though; O157:H7 carries a toxin-encoding phage that can infect and kill susceptible E. coli strains. Those Nissle cells that survived this infection could resist the phage, but were not as beneficial to the organoids due to the toxin they now produced. Journal Paper: Pradhan S, Weiss AA. 2020. Probiotic Properties of Escherichia coli Nissle in Human Intestinal Organoids. mBio 11(4):e01470-20. Other interesting stories: Certain gut microbes can help people resist cholera Photosynthetic microbes engineered to produce spider silk   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
432: Moses Microbes Maintain Moisture

BacterioFiles

Play Episode Listen Later Sep 7, 2020 5:24


This episode: Bacteria living in the driest place on earth have ways to extract water from the mineral structures of rocks! Download Episode (3.7 MB, 5.4 minutes) Show notes: Microbe of the episode: Irkut lyssavirus   News item Takeaways Microbes living in extremely dry conditions have it tough. Water is important both for the chemistry and structure of all cells. Desert microbes are very good at acquiring and holding on to the water they can find, but in places such as the Atacama Desert in Chile, there's almost none available.   However, microbes can be very resourceful. In this study, phototrophs were discovered that can actually extract water molecules bound up in the crystalline structure of the mineral gypsum, and this allows them to survive in hyperarid regions. They do this by secreting organic acid molecules to etch the rock and release the water, converting gypsum to anhydrite, which is a mineral with the same chemical structure except without the water. Journal Paper: Huang W, Ertekin E, Wang T, Cruz L, Dailey M, DiRuggiero J, Kisailus D. 2020. Mechanism of water extraction from gypsum rock by desert colonizing microorganisms. Proc Natl Acad Sci 117:10681–10687. Other interesting stories: Cholesterol-lowering drugs associated with fewer gut microbiota problems Using bacterial hormones to get bacteria to produce more interesting molecules   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
431: Conductive Cables Control Carbon

BacterioFiles

Play Episode Listen Later Aug 31, 2020 8:18


This episode: Cable bacteria around rice roots transport electrons and help prevent formation of methane!   Thanks to Vincent Scholz for his contribution! Download Episode (5.7 MB, 8.3 minutes) Show notes: Microbe of the episode: Vibrio alginolyticus   News item Takeaways Transforming other things into methane is a great way to make a living for some kinds of microbes. These tend to live under still water, like in rice fields or wetlands, or in the guts of cattle. And while this methane could be useful as natural gas if collected, it's a much more potent greenhouse gas than carbon dioxide when released into the atmosphere.   In this study, cable bacteria were inoculated into rice pots in the lab. Cable bacteria transfer electrons from deeper down in the ground up to the surface to generate energy, and in the process generate sulfate. This sulfate allows other microbes to outcompete the methane producers, reducing the amount of methane produced from rice cultivation in the lab. This may be helpful to reduce greenhouse gas emissions from rice agriculture. Journal Paper: Scholz VV, Meckenstock RU, Nielsen LP, Risgaard-Petersen N. 2020. Cable bacteria reduce methane emissions from rice-vegetated soils. 1. Nat Commun 11:1878. Other interesting stories: Viruses in fecal transplants, not just bacteria, may be useful for health Superworms and their symbiont bacteria can degrade styrofoam   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
430: Dextrose Deposits Delay Dormancy

BacterioFiles

Play Episode Listen Later Aug 24, 2020 10:26


This episode: Bacteria that can store sugar as glycogen have multiple advantages when food is only available sporadically! Download Episode (7.2 MB, 10.4 minutes) Show notes: Microbe of the episode: Carnivore bocaparvovirus 3 Takeaways Almost all habitats experience some sort of change and fluctuation; very few are totally stable, depending on the timeframe. So strategies to change and adapt with changing conditions can greatly help an organism thrive. For example, methods of storing energy are helpful when food is only available sporadically.   Some bacteria, like humans, can store sugar in a polymer called glycogen, which can be quickly produced when food is abundant and quickly broken down to ease a transition to fasting. In this study, bacteria that could produce and use glycogen were able to stay active longer and grow better in the face of intermittent starvation. They were even better able to acquire new food when more became available. Journal Paper: Sekar K, Linker SM, Nguyen J, Grünhagen A, Stocker R, Sauer U. 2020. Bacterial Glycogen Provides Short-Term Benefits in Changing Environments. Appl Environ Microbiol 86. Other interesting stories: Bacteria can grow so well in spent nuclear fuel ponds, they make the water cloudy Certain probiotic bacteria might be able to degrade gluten and protect people with celiac   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
429: Springtails Smell, Spread Streptomyces

BacterioFiles

Play Episode Listen Later Aug 17, 2020 9:02


This episode: Bacteria in soil produce smells to attract arthropods that eat them but also spread their spores! Download Episode (6.2 MB, 9.0 minutes) Show notes: Microbe of the episode: Blotched snakehead virus   News item Takeaways Soil, especially after a rain, often has a characteristic "earthy" smell. This soil smell is actually the result of certain bacteria producing a volatile chemical called geosmin. Many geosmin producers are in the Streptomyces genus, which produces a large variety of interesting chemicals, but geosmin is one of the few that is nearly universal in the genus.   This study found that insect-like arthropods called springtails are attracted to geosmin. These animals usually feed on fungi, but they will also eat bacteria when available. Despite this result, the bacteria continue to produce the chemical, which is linked to their sporulation cycle. The study found that springtails carry intact bacterial spores to new places stuck to the insides and outsides of the animal, and this enhances the dispersal ability of the bacteria. Journal Paper: Becher PG, Verschut V, Bibb MJ, Bush MJ, Molnár BP, Barane E, Al-Bassam MM, Chandra G, Song L, Challis GL, Buttner MJ, Flärdh K. 2020. Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal. 6. Nat Microbiol 5:821–829. Other interesting stories: Silicon nanowires help bacteria harvest light to fix carbon dioxide Bacterium produces membrane balls containing enzymes to help digest lignin   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
428: Microbes May Manage Mysteries

BacterioFiles

Play Episode Listen Later Aug 10, 2020 7:54


This episode: The skin microbes that people leave behind may be used to identify them, even after other people have touched the same surface! Download Episode (5.4 MB, 7.9 minutes) Show notes: Microbe of the episode: Actinobacillus lignieresii Takeaways The microbial communities in and on our bodies are highly complex and highly varied between people; this complexity has raised the question of whether the microbes that people transfer onto things they touch could be used in forensics, to track their movement and activity, like fingerprints or DNA evidence. One difficulty with this approach is that microbe communities are constantly changing as conditions change or other microbes are introduced.   This study simulated such microbial tracking in a couple of scenarios, such as touching door handles in an office building and touching various surfaces in a home in a mock burglary. Tracking a person on door handles worked fairly well for up to an hour after the contact, even if other people had also touched the same door handles. However, the accuracy of identifying the "burglar" in a home was not very high, but modifying the analysis from looking at the community as a whole to only rare microbes relatively unique to an individual improved the results. Journal Paper: Hampton-Marcell JT, Larsen P, Anton T, Cralle L, Sangwan N, Lax S, Gottel N, Salas-Garcia M, Young C, Duncan G, Lopez JV, Gilbert JA. 2020. Detecting personal microbiota signatures at artificial crime scenes. Forensic Sci Int 313:110351. Other interesting stories: Using slime molds to model the gravity-based web of gas and dark matter between galaxies Using bacteria to produce antibody-like molecules (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
427: Simple Cells Stay Strong

BacterioFiles

Play Episode Listen Later Aug 3, 2020 14:58


This episode: Bacterial cells with their genomes removed can still be active and useful! Download Episode (10.2 MB, 14.9 minutes) Show notes: Microbe of the episode: Rosavirus A Takeaways Microbes have amazing biochemical transformation abilities, creating and breaking down many compounds and proteins. This makes them great candidates for many purposes, in medicine, industry, and environmental remediation. In some of these purposes, though, there are risks associated with adding foreign microbes, especially engineered ones, that can replicate themselves and possibly persist, into new places.   To avoid this risk, this study turns intact bacteria into SimCells, simplified entities with most of their genetic material removed, leaving only the proteins and other components and just enough DNA to accomplish desired tasks. These SimCells were able to continue performing tasks for around 10 days before running out of the cellular resources needed to keep going. One of these tasks was producing a compound that damaged cancer cells in a dish but left non-cancerous cells unharmed. Journal Paper: Fan C, Davison PA, Habgood R, Zeng H, Decker CM, Salazar MG, Lueangwattanapong K, Townley HE, Yang A, Thompson IP, Ye H, Cui Z, Schmidt F, Hunter CN, Huang WE. 2020. Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology. Proc Natl Acad Sci 117:6752–6761. Other interesting stories: Biofuel-producing bacteria can generate electricity at the same time (paper) Using dried microbial biomass as fertilizer works pretty well (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Lunch and Learn with Dr. Berry
Mental Wellness in the Black Community with Tiara Riley

Lunch and Learn with Dr. Berry

Play Episode Listen Later Jul 27, 2020 51:37


Let's talk about Mental Wellness in the Black Community... On this week's episode of the Lunch and Learn with Dr. Berry we have Tiara Nicole Riley, a motivational speaker who focuses on mental health, time management, and women's empowerment. She has experience speaking to large and intimate audiences while maintaining connection and engagement throughout. In this episode, we talk about mental wellness in the Black community, her passion on mental health and how they help her produce not one but 3 books with a fourth on the way. Text LUNCHLEARNPOD to 44222 today or sign up at www.listentodrberry.com to join the mailing list.   Remember to subscribe to the podcast and share the episode with a friend or family member. Listen on Apple Podcast, Google Play, Stitcher, Soundcloud, iHeartRadio, Spotify Sponsors: Lunch and Learn Community Online Store (code Empower10) Pierre Medical Consulting (If you are looking to expand your social reach and make your process automated then Pierre Medical Consulting is for you) Dr. Pierre's Resources – These are some of the tools I use to become successful using social media My Amazon Store – Check out all of the book recommendations you heard in the episode Links/Resources: Official Website Books (Remember to use the code social for 20% off) Instagram Twitter Facebook Youtube LinkedIn Social Links: Join the lunch and learn community – https://www.drberrypierre.com/joinlunchlearnpod Follow the podcast on Facebook – http://www.facebook.com/lunchlearnpod Follow the podcast on twitter – http://www.twitter.com/lunchlearnpod – use the hashtag #LunchLearnPod if you have any questions, comments or requests for the podcast For More Episodes of the Lunch and Learn with Dr. Berry Podcasts https://www.drberrypierre.com/lunchlearnpodcast/ If you are looking to help the show out Leave a Five Star Review on Apple Podcast because your ratings and reviews are what is going to make this show so much better Share a screenshot of the podcast episode on all of your favorite social media outlets & tag me or add the hashtag. #lunchlearnpod Download Episode 156 Download the MP3 Audio file, listen to the episode however you like.

BacterioFiles
426: Sensory Cilia Supply Susceptibility

BacterioFiles

Play Episode Listen Later Jul 27, 2020 8:42


This episode: A fungus paralyzes its tiny worm prey by acting on the worm's own sensory hairs! Download Episode (6.0 MB, 8.7 minutes) Show notes: Microbe of the episode: Bat associated cyclovirus 9 Takeaways Not all predators are fast or agile; some are sneaky, or good trap builders, or just good chemists. The predator club includes animals but also plants and even fungi. For example, the oyster mushroom fungus can paralyze roundworms in the soil that touch its filaments, then degrade their bodies and consume their nutrients.   The mechanism of this paralysis has been a mystery, but it's one step closer to being solved. This study found that intact sensory cilia, little hairs on the worm's head that help it sense its surroundings, are required for the paralysis to work. Worms with mutations in the structure of their cilia were protected from paralysis. How exactly the fungus acts on these cilia and the neurons they connect to, though, is still unknown. Journal Paper: Lee C-H, Chang H-W, Yang C-T, Wali N, Shie J-J, Hsueh Y-P. 2020. Sensory cilia as the Achilles heel of nematodes when attacked by carnivorous mushrooms. Proc Natl Acad Sci 117:6014–6022. Other interesting stories: Bread waste could be good food for useful fermentations Symbiotic bacteria in beetle picked up gene that helps defend beetle eggs from fungus   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Real Life Friends
Real Life Friends 156 - Matt & Al's Christmas Special!

Real Life Friends

Play Episode Listen Later Jul 26, 2020 62:37


Download Episode https://www.mediafire.com/?jtjw8xw7h7... Blastropodcast http://blastropodcast.com/ Stoneship Radio https://itun.es/i6SQ39b The Critical Miss https://www.youtube.com/user/TheCriti... =Music= "Wish Background" Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 3.0 http://creativecommons.org/licenses/b... Twitter: https://twitter.com/AlChestBreach Twitch: http://www.twitch.tv/realalchestbreach Instagram: https://www.instagram.com/albertchest... Spreadshirt: http://alchestbreach.spreadshirt.com/

Lunch and Learn with Dr. Berry
No place for discrimination in medicine with Dr. Kat Ogle

Lunch and Learn with Dr. Berry

Play Episode Listen Later Jul 20, 2020 59:53


Let's talk about No place for discrimination in medicine... On this week's episode of the Lunch and Learn with Dr. Berry we have Dr. Kat Ogle a board-certified Emergency Medicine physician, currently practicing at The George Washington University Hospital, Washington VA Medical Center and United Medical Center in Washington, DC. As a first-generation college graduate and physician she began her career as a registered nurse. Dr. Ogle is on faculty at George Washing University where she serves as the medical instructor for residents, medical students & fellows. This week we have Dr. Ogle on the show to discuss her contribution to the "The Chronicles of Women in White Coats Vol 2". We have an amazing conversation on inclusion and the need to remove the discriminatory practices in medicine. Text LUNCHLEARNPOD to 44222 today or sign up at www.listentodrberry.com to join the mailing list.   Remember to subscribe to the podcast and share the episode with a friend or family member. Listen on Apple Podcast, Google Play, Stitcher, Soundcloud, iHeartRadio, Spotify Sponsors: Lunch and Learn Community Online Store (code Empower10) Pierre Medical Consulting (If you are looking to expand your social reach and make your process automated then Pierre Medical Consulting is for you) Dr. Pierre's Resources – These are some of the tools I use to become successful using social media My Amazon Store – Check out all of the book recommendations you heard in the episode Links/Resources: https://www.thechroniclesofwomeninwhitecoats.com/dr-kat-ogle Instagram Instagram Social Links: Join the lunch and learn community – https://www.drberrypierre.com/joinlunchlearnpod Follow the podcast on Facebook – http://www.facebook.com/lunchlearnpod Follow the podcast on twitter – http://www.twitter.com/lunchlearnpod – use the hashtag #LunchLearnPod if you have any questions, comments or requests for the podcast For More Episodes of the Lunch and Learn with Dr. Berry Podcasts https://www.drberrypierre.com/lunchlearnpodcast/ If you are looking to help the show out Leave a Five Star Review on Apple Podcast because your ratings and reviews are what is going to make this show so much better Share a screenshot of the podcast episode on all of your favorite social media outlets & tag me or add the hashtag. #lunchlearnpod Download Episode 155 Download the MP3 Audio file, listen to the episode however you like.

Lunch and Learn with Dr. Berry
Discrimination in the Medical Field with Dr. Petrina Craine

Lunch and Learn with Dr. Berry

Play Episode Listen Later Jul 13, 2020 56:59


Let's talk about Discrimination in the Medical Field... On this week's episode of the Lunch and Learn with Dr. Berry we have Dr. Petrina Craine from Memphis, TN. She is an Emergency Room Physician currently practicing in New York. Her interests include advocating for underserved communities, promoting diversity and inclusion, and creating health media as a physician journalist. This week she is on the show to discuss her recent contribution to the anthology "The Chronicles of Women in White Coats Vol 2". Find out how she has been able to deal with racism throughout her process of medical education, the toughest part about being a black woman in medicine and what she is doing to help bridge the gap. Text LUNCHLEARNPOD to 44222 today or sign up at www.listentodrberry.com to join the mailing list.   Remember to subscribe to the podcast and share the episode with a friend or family member. Listen on Apple Podcast, Google Play, Stitcher, Soundcloud, iHeartRadio, Spotify Sponsors: Lunch and Learn Community Online Store (code Empower10) Pierre Medical Consulting (If you are looking to expand your social reach and make your process automated then Pierre Medical Consulting is for you) Dr. Pierre's Resources – These are some of the tools I use to become successful using social media My Amazon Store – Check out all of the book recommendations you heard in the episode Links/Resources: https://www.thechroniclesofwomeninwhitecoats.com/dr-petrina-craine Instagram Social Links: Join the lunch and learn community – https://www.drberrypierre.com/joinlunchlearnpod Follow the podcast on Facebook – http://www.facebook.com/lunchlearnpod Follow the podcast on twitter – http://www.twitter.com/lunchlearnpod – use the hashtag #LunchLearnPod if you have any questions, comments or requests for the podcast For More Episodes of the Lunch and Learn with Dr. Berry Podcasts https://www.drberrypierre.com/lunchlearnpodcast/ If you are looking to help the show out Leave a Five Star Review on Apple Podcast because your ratings and reviews are what is going to make this show so much better Share a screenshot of the podcast episode on all of your favorite social media outlets & tag me or add the hashtag. #lunchlearnpod Download Episode 154 Download the MP3 Audio file, listen to the episode however you like.

Nerdvana Podcast
Nerdvana 104 – Mit weniger gerülpse

Nerdvana Podcast

Play Episode Listen Later Jul 8, 2020 0:01


Download Episode 104 00:04:25 – Intro 00:08:00 – Red Dwarf – The Promised Land Serie, UK, 2020 Craig Charles (Dave Lister), Chris Barrie (Arnold Rimmer), Danny John-Jules (Cat), Robert Llewellyn (Kryten), Norman Lovett (Holly) Trailer Homepage Letterboxd IMDb Wikipedia 00:32:12 … Continue reading →

NINE TO 5ER
Ep. 2.0 - How To Overcome Your Fear of Public Speaking

NINE TO 5ER

Play Episode Listen Later Jul 8, 2020


Andrea shares 5 Tips on How To Overcome Your Fear of Public Speaking.Download Episode 2.0

BacterioFiles
425: Paired Predators Prevent Pathogen Persistence

BacterioFiles

Play Episode Listen Later Jun 22, 2020 9:55


This episode: This episode: A bacteriophage and bacterial predator can wipe out a population of bacteria that could develop resistance to each individually! Thanks to Laura Hobley, J. Kimberley Summers, and Jan-Ulrich Kreft for their contributions!   Also a note: I will be taking a short break from podcasts while I rebuild my collection of awesome microbiology stories to talk about. Download Episode (6.8 MB, 9.9 minutes) Show notes: Microbe of the episode: Blackbird associated gemycircularvirus 1 Takeaways Bacteriophages and bacterial predators that prey on other bacteria are both very good at killing large numbers of bacteria. But bacteria as a whole are also very good at surviving being killed in large numbers; there are almost always a few that have the right genes to overcome whatever is doing the killing. This is what makes the threat of antibiotic resistance so scary, and why phage therapy is both very promising and very limited.   In this study, however, a combination of phages and the bacterial predator Bdellovibrio bacteriovorans is able to completely eradicate a population of bacteria, or at least reduce their numbers below a detectable level. A mathematical model based on these data predicts that despite the two killers working independently, they can effectively eliminate all the individual prey organisms that would otherwise be able to resist killing by either one alone. Journal Paper: Hobley L, Summers JK, Till R, Milner DS, Atterbury RJ, Stroud A, Capeness MJ, Gray S, Leidenroth A, Lambert C, Connerton I, Twycross J, Baker M, Tyson J, Kreft J-U, Sockett RE. 2020. Dual Predation by Bacteriophage and Bdellovibrio bacteriovorus Can Eradicate Escherichia coli Prey in Situations where Single Predation Cannot. J Bacteriol 202. Other interesting stories: Combination of beneficial bacteria could substitute for fertilizer somewhat (paper) Gut bacteria turn broccoli molecules into potentially healthy compounds   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
424: Stranger Cells Switch Stable States

BacterioFiles

Play Episode Listen Later Jun 15, 2020 9:11


This episode: Certain bacteria can greatly affect the makeup of a microbial community, even if they quickly disappear!   Thanks to Dr. Daniel Amor for his contribution! Download Episode (6.3 MB, 9.2 minutes) Show notes: Microbe of the episode: Gadgets Gully virus News item Takeaways Microbial communities show more than just competition between species. Stable assemblies of many species can exist for long periods in places like the human gut, despite constant minor shifts in conditions. More major shifts, or invaders like pathogens coming in and taking over, can cause big disruptions in the community and lead to long-term gut dysbiosis, which can be, interestingly, also a stable community.    This study shows that invaders into a community, even if they don't persist for very long, can cause a shift from one stable state to another, by favoring the dominance of a species or group that was not dominant before, for example by changing the pH of the environment. So competition is always present. This could be helpful to know for efforts to intentionally shift community structures. Journal Paper: Amor DR, Ratzke C, Gore J. 2020. Transient invaders can induce shifts between alternative stable states of microbial communities. Sci Adv 6:eaay8676. Other interesting stories: Symbiotic bacteria engineered to protect honeybees from pathogens Mouse diet differences in fiber show much more effect on microbiome than differences in fat (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

BacterioFiles
423: Roundworm Riders Route Rootworm Resistance

BacterioFiles

Play Episode Listen Later Jun 8, 2020 13:58


This episode: Helping insect-killing bacterial symbionts of nematodes evolve resistance to chemicals that major corn pests use to defend themselves! Download Episode (10.0 MB, 14.0 minutes) Show notes: Microbe of the episode: Listeria virus PSA Takeaways Interactions between species and even kingdoms in nature can be complex and multilayered. This means that when we want to intervene to cause a particular outcome, there may be multiple points at which we can act, but the consequences may be hard to predict.   In this study, action was taken to counteract the damage the Western corn rootworm causes to corn crops, using a tiny roundworm that attacks the insect pest with deadly bacteria. The rootworm defends itself by accumulating plant-produced toxins that inhibit the bacteria. Directed evolution was used to make the bacteria more resistant, and this led to more effective killing of the pest. Journal Paper: Machado RAR, Thönen L, Arce CCM, Theepan V, Prada F, Wüthrich D, Robert CAM, Vogiatzaki E, Shi Y-M, Schaeren OP, Notter M, Bruggmann R, Hapfelmeier S, Bode HB, Erb M. 2020. Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm. 5. Nat Biotechnol 38:600–608. Other interesting stories: Altering pathogenic bacteria to reduce disease with genome-integrating phage (paper) Bacteria could inhibit fungus that causes deadly disease of bananas (paper)   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Holy Calling
L.A.B. chat #8 with Sharon Pearce

Holy Calling

Play Episode Listen Later Jun 5, 2020 58:14


Download Episode!   My guest for episode #8 is Sharon Pearce, the founder and executive director of Silent Voices Pregnancy Care Center.  I reached out to Sharon when I shared my story of having had an abortion at our annual women's conference several years ago and then had several women come to me silently via texts and email to thank me for sharing my story and to share their stories with me. I reached out to her to be able to refer some for follow-up who need more counseling. Then a few months ago a saw Sharon at a ministry event and asked her to be on the podcast. During our chat, Sharon shared her story of working in the abortion industry and how that affected her to the point of a mental breakdown, and how God in His mercy healed her and lead her to start Silent Voices to help women make the decision to keep their babies. Sharon's mission is to help women make the decision to keep their babies and to support them through motherhood, and bring healing to those women who have had abortions. Maybe you've never had an abortion but you've experienced God's grace giving you beauty for the ashes of something you've been through. Maybe you know someone who's had an abortion. If so, would you please share this podcast with them. Either way, I'm sure as always that you will see a little of yourself in Sharon story of God's love, acceptance, and beauty shaping her identity and the way she lives out her faith. What Silent Voices Offers: Silent Voices offers a host of confidential services including free pregnancy tests, counseling and loving support to women facing unplanned or crisis pregnancies who often feel pressured to have an abortion throughout their pregnancies. Silent Voices has two support groups - Bridges to Motherhood for any woman who is either pregnant or has recently had a baby, who is looking for support, friendship and assistance and Post Abortion Healing & Recovery Group which is done as a weekend experience, plus Bible Studies. They also offer sex, pregnancy, and abortion education, natural family planning, as well as help and counseling for those women who choose to have abortions.     Sharon's Motto/Verse: "Sing, O barren one, who did not bear; break forth into singing and cry aloud, you who have not been in labor! For the children of the desolate one will be more than the children of her who is married,” says the Lord." (Isaiah 54:1) You can donate to help with the mobile unit here:  http://www.silentvoices.org/donate-now.html Going mobile will allow Silent Voices/Real Choices to meet women where they are, and to help them in their most vulnerable moments by providing a Free Ultrasound on the Mobile! Volunteer with Silent Voices: http://www.silentvoices.org/volunteer.html Silent Voices on Facebook https://www.facebook.com/Silent-Voices-International Sow A Bible into Silent Voices Bible Studies through Gardeness Ministries  http://www.gardenessministries.com/sow Connect with me: www.kristapettiford.com

BacterioFiles
422: Frigid Phototrophs Fuel Fords

BacterioFiles

Play Episode Listen Later Jun 1, 2020 12:35


This episode: Producing both biodiesel and bioethanol fuels from cold-loving Arctic algae! Download Episode (8.7 MB, 12.6 minutes) Show notes: Microbe of the episode: Royal Farm virus Takeaways Renewable fuels such as biofuels can allow existing infrastructure and vehicles to continue to operate in a more sustainable manner, which could reduce the cost and impact of switching to new/different systems of transportation like electricity. Economically competitive methods of producing biofuels are still being explored and developed.   In this study, Arctic algae are grown in cold temperatures using only light, carbon dioxide, and a few minerals, and then broken down to produce biodiesel and bioethanol, which can be used as fuel in many different internal combustion engines. The amounts produced are comparable to other algae-based systems being researched, and use of the cold-loving organisms could reduce the cost of production in colder latitudes and seasons. Journal Paper: Kim EJ, Kim S, Choi H-G, Han SJ. 2020. Co-production of biodiesel and bioethanol using psychrophilic microalga Chlamydomonas sp. KNM0029C isolated from Arctic sea ice. Biotechnol Biofuel 13:20. Other interesting stories: Certain foods could activate or inhibit bacteriophages and modulate the gut microbiota Some antibiotic-producing bacterial colonies have specialized members that do all the antibiotic production   Email questions or comments to bacteriofiles at gmail dot com. Thanks for listening! Subscribe: Apple Podcasts, Google Podcasts, Android, or RSS. Support the show at Patreon, or check out the show at Twitter or Facebook.

Globally Speaking Radio
A New Chapter for the Multilingual Publishing Industry

Globally Speaking Radio

Play Episode Listen Later Aug 28, 2019


In this episode of Globally Speaking, we chat with Margaret Ann Dowling, CEO of Create&Translate.org, about the magazine publishing industry. She explains the current global licensing model for multilingual publication and why it needs to evolve to become more reader-focused. She also talks about the need to create more content that enables collaboration across cultures and markets and the similarities between the loc and publishing worlds. Click Play or Download Episode below and thanks for listening!

Some Would Say
Some Would Say 040 - WORLD DOMINATION

Some Would Say

Play Episode Listen Later Aug 6, 2019


Welcome back! A very special guest joins us this time, someone who may have been bitten by the bug when we recorded a couple pre-rolls for Some Would Play that became Some Would Say episodes, @sonjataki! We spend a lot of time talking about high school and taking over the world. We chat about the future of Some Would Play as well. There were a ton of potential titles in this one. Join us!Download Episode 40Follow us on Facebook and Twitter!Facebook.com/SomeWouldSayPodTwitter.com/SomeWouldSayPodDebrah: twitter.com/sonjatakiJenna: twitter.com/jennatullDaphne: twitter.com/daphterthoughtMatt: twitter.com/psychadelicm

Art of Advisory with Hector Garcia CPA & Kirk Bowman
AltAccountant Podcast #8 – Geni Whitehouse & How to make boring topics interesting

Art of Advisory with Hector Garcia CPA & Kirk Bowman

Play Episode Listen Later Jul 31, 2019


Download Episode: http://hectorgarcia.com/wp-content/PODCAST/AltaccountantPodcast8.m4a

Some Would Say
Some Would Say 038 - The Matt and Rico Show

Some Would Say

Play Episode Listen Later Jul 3, 2019


We back! Jenna and Daphne were not available, but Matt and Rico still wanted to record...so we did that thing. We chat about Pokemon Go, the debates, India, cannabis, memes, anime, and nuts.Download Episode 38Follow us!facebook.com/SomeWouldSaytwitter.com/SomeWouldSayPodMatt is at twitter.com/psychadelicmRico is at twitter.com/r1c0

Art of Advisory with Hector Garcia CPA & Kirk Bowman
AltAccountant Podcast #7 – Value Pricing vs. Productized/Subscription Services

Art of Advisory with Hector Garcia CPA & Kirk Bowman

Play Episode Listen Later Jun 30, 2019


Download Episode: http://hectorgarcia.com/wp-content/PODCAST/AltaccountantPodcast7.mp3

Art of Advisory with Hector Garcia CPA & Kirk Bowman
AltAccountant Podcast #6 – Why we need a Manifesto, talking about Blair Enns Book: “Win Without Pitching Manifesto”

Art of Advisory with Hector Garcia CPA & Kirk Bowman

Play Episode Listen Later May 31, 2019


Download Episode: http://hectorgarcia.com/wp-content/PODCAST/AltaccountantPodcast6.mp3

Art of Advisory with Hector Garcia CPA & Kirk Bowman
AltAccountant Podcast #5 – Positioning and Strategy for Professionals with Tim Williams

Art of Advisory with Hector Garcia CPA & Kirk Bowman

Play Episode Listen Later Apr 30, 2019


Download Episode: http://hectorgarcia.com/wp-content/PODCAST/AltaccountantPodcast5.mp3

NBA Trades Podcast
NBA Trades Podcast Episode #57 Featuring Jared Weiss

NBA Trades Podcast

Play Episode Listen Later Apr 12, 2019


Jared Weiss of The Athletic came on the pod to preview the Boston Celtics first round matchup with the Indiana Pacers. The Celtics finished the season 49-33 which fell short of expectations coming into the season. Still, the Celtics have a chance to make some noise in the postseason.We spoke about Marcus Smart’s injury and its impact on Boston’s playoff hopes, Jaylen Brown as a replacement, Gordon Hayward’s effectiveness and the Kyrie Irving situation throughout the season.Download Episode 57

NBA Trades Podcast
NBA Trades Podcast Episode #56 Featuring Steve Aschburner

NBA Trades Podcast

Play Episode Listen Later Apr 5, 2019


Back in the summer of 2003, the Minnesota Timberwolves made a splash on the trade market, acquiring veterans Sam Cassell and Latrell Sprewell. The two players formed a powerful trio with Kevin Garnett and won 58 games during the 2003-04 season. Garnett won MVP and Minnesota won their first playoff series in franchise history on their way to a Conference Finals appearance.Though the Wolves brought back the same cast for the 2004-05 season, the team fell apart. Coach Flip Saunders was fired and the team missed the playoffs. I had Steve Aschburner from NBA.com on to talk about that successful team and their quick rise and fall.Steve covered the Wolves for the Star Tribune and was there for all of those big moments in that one great season.Download Episode 56

Some Would Say
Some Would Say 037 - Cloacal Kiss or Dinosaur Boner?

Some Would Say

Play Episode Listen Later Apr 4, 2019


Did you miss us? We're back! The gang is all here for this one as we talk about a variety of topics. If life is a simulation, who is our programmer? Good old Fred and meme that wasn't. PsychadelicM is wrong alot in this episode...in more ways then one, unfortunately. He apologizes. Pornography! Jenna drops a bunch of jokes that fall flat...just like the Earth. Shit gets real when Jenna calls into question Matt's faith again, and then they argue about pedophiles. Is the podcast over forever? Tune in!Download Episode 037Follow us!twitter.com/SomeWouldSayPodfacebook.com/SomeWouldSayPodJenna is @JennaTullDaphne is @DaphterthoughtMatt is @psychadelicm

Art of Advisory with Hector Garcia CPA & Kirk Bowman
AltAccountant Podcast #4 – Intuit/QuickBooks is now offering bookkeeping services, What does it mean to us?

Art of Advisory with Hector Garcia CPA & Kirk Bowman

Play Episode Listen Later Mar 31, 2019


Download Episode: http://hectorgarcia.com/wp-content/PODCAST/AltaccountantPodcast4.m4a

NBA Trades Podcast
NBA Trades Podcast Episode #55 Featuring Scott Agness

NBA Trades Podcast

Play Episode Listen Later Mar 26, 2019


The Indiana Pacers have been one of the pleasant surprises of the NBA season. Despite losing All-Star Victor Oladipo, Indiana’s still in position to have homecourt advantage in the opening round of the playoffs.I had Scott Agness on to talk about Indiana’s surprising season, the Myles Turner, Domantas Sabonis conundrum, the solid bench play this season and the expectations for the team heading into the playoffs.Download Episode 55