Podcasts about phages

Virus that infects and replicates within bacteria

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Best podcasts about phages

Latest podcast episodes about phages

Let's Talk Wellness Now
Episode 252 – Induced Native Phage Therapy (INPT) & advanced natural therapies

Let's Talk Wellness Now

Play Episode Listen Later Jan 6, 2026 66:33


David Jernigan 0:15Hello! Dr. Deb 0:16Hi there, sorry for all the confusion. David Jernigan 0:19Oh, no worries, you gotta love it, right? Dr. Deb 0:21Oh, I can’t hear you. David Jernigan 0:23No way, let’s see, my mic must be turned off? Dr. Deb 0:27Hang on, I think it’s me. Let’s see…Okay, let’s try now. David Jernigan 0:40Okay, can you hear me? Dr. Deb 0:42Yep, I can hear you now. David Jernigan 0:43Excellent, excellent. And, how are you today? Dr. Deb 0:48I am good, thank you. How about yourself? David Jernigan 0:50I’m good. Well, it’s good to finally meet you and get this thing rolling. Dr. Deb 0:56Yes, yes, I’m so sorry about that. David Jernigan 0:58That’s alright, that’s alright.So… Dr. Deb 1:01Yeah, go ahead. David Jernigan 1:03So, tell me about yourself before we get going. Dr. Deb 1:06Yeah, so I am a nurse practitioner. I’m also a naturopath. I have a practice here in Wisconsin. I’ve been treating Lyme for about 20 years, so I’m really excited to have this conversation and learn what you’re doing, because it’s so exciting and new. David Jernigan 1:21Well, thank you. Dr. Deb 1:22Yeah, so we treat a lot of chronic illness patients, do some anti-aging regenerative things as well, so… David Jernigan 1:30Yeah, I went to your website and saw you guys are killing it, looks like. Dr. Deb 1:35Yeah. David Jernigan 1:35Got a lot of good staff, it looks like. Dr. Deb 1:37Yeah, we’ve got great staff, great patients, busy practice. We have 5 practitioners, so we have about 15,000 patients in our practice right now. David Jernigan 1:46Well, excellent. Yeah. Excellent. Yeah, yeah.So, I’m excited for this discussion. Dr. Deb 1:53Good, me too. So I pre-recorded our intro, so we can just kind of dive right in, and I’ll just ask you to kind of introduce yourself a little bit, tell us a little bit about yourself, and, and then we can just dive right into it. David Jernigan 2:08All right. I’m Dr. David Jernigan, and I own the Biologic Center for Optimum Health in… Franklin, Tennessee, and I’ve been in practice for over 30 years. I shook Willie Bergdurfer’s hand, if anybody knows who that is. It’s kind of infamous now with some of the revelations that have happened about Lyme being a bioweapon and weaponized. But, you know, I’ve been doing this, probably longer than almost anybody that’s still in the business in the natural realm. It chose me. I did not choose Lyme. Matter of fact, there were many times in my career that I was like. You know, cancer’s easier because of the fact that everybody agrees, you know, what we’re dealing with. And in the 90s, it was a whole different reality, where nobody actually understood that you could have Lyme disease and not be coming from New England.You know, so I had actually the first documented case of a Lyme disease, CDC positive.Patient that had never left the state of Kansas before. So they couldn’t say that it wasn’t in Kansas, and so she had actually been, pregnant with… twin boys, and they were born CDC-positive as well, and so it is transmitted across the placenta we know.So, I, you know, the history of how I did all this was, in the 90s, probably 1996, probably, somewhere in there, 97. With this woman, you know, I… if you go into Robin’s pathology books from back then. Which we all used, medical doctors and everybody else studying. you know, there was basically a paragraph about Lyme disease, and on the national board tests, as you recall, it was probably like, what causes, or what is, bullseye rash associated with? And you’d had to guess Lyme disease, of course. Dr. Deb 4:07Female. David Jernigan 4:08But that was, you know, considered to be more a New England illness, and you would never see it anywhere else. But here was this woman. I knew… nothing about Lyme beyond what we had gotten taught in college, which was, like I say, next to nothing. And she would not let me stop feeding me information. I mean, you gotta remember, the internet wasn’t even hardly in existence in those years. I mean, it was brand new. It was supposed to be this information highway, and So I started purchasing, like a lot of doctors do even now, they start purchasing every kind of new supplement that’s supposed to work for bacteria. There was no product in those days that actually was Lyme-specific. I mean, nobody was really dealing with it naturally. It was always a pharmaceutical situation. Dr. Deb 5:04And a very short course at that. David Jernigan 5:06Yeah, 2 weeks of doxy and you’re cured, whether your symptoms are gone or not, which… she’d had the 2 weeks of doxy, and her symptoms and her son’s symptoms were not gone. And so, I absolutely just purchased everything I could find. Nothing would work. I mean, I could name names of products, and you would recognize them, because they’re still out there today. Dr. Deb 5:28Which is. David Jernigan 5:30Kind of a… A sad thing that natural medicine is still riding on these things that have the most marketing. Dr. Deb 5:37As opposed to sometimes the things that actually have the documented research. David Jernigan 5:42Behind it, and I am a doctor of chiropractic medicine, and I specialized all these years in chronic, incurable illnesses of all types. That may sound odd to a lot of people, but doctors of chiropractic medicine are trained just like a GP typically would be. The medical schools, as I understand it, got together, decades ago and said, wow, if all we did was… Crank out general practitioners for the next 10 years, we wouldn’t have still enough general practitioners to supply the demand. Dr. Deb 6:17Right. Everybody in medicine, in medical schools, wanted to be a specialist, because that’s where the money was, and it was… David Jernigan 6:24Easier, kind of, also, to… you know, just focus on one part of the body, and specialize in that. Dr. Deb 6:31Expert in that one area. David Jernigan 6:32So we all now have the same training. We all go through pre-med. We got a bachelor’s degree, I got my bachelor’s degree in nutrition, and through, Park University in Parkville, Missouri. And so, you know, when I ran out of options to purchase, I just used a technology that I developed, which was an advancement upon other technologies, but I called it bioresonance scanning. And I coined the term back in the 90s. It was a way to kind ofKind of like a sensitive test, you know, like you might. Dr. Deb 7:09I wouldn’t. David Jernigan 7:09Of applied kinesiology, then clinical kinesiology, then chiro plus kinesiology, then, you know, you can just keep going with all the advancements that were made. Well, this was an advancement upon those things, so… I developed… I was the first in… in… my known world of doctors to develop a way to detect adjunctively, obviously we can’t say it’s a primary diagnosis. Adjunctively detect the presence of a given specimen. So we could say, thus saith my test. It’s highly likely you have Borrelia burgdurferi. And, but I had to have the specimen on hand to be able to match what I call frequency matching to the specimen. Brand new concept in those days. And so I was able to detect whether or not my treatments were successful or not. This is something even now that’s really difficult for doctors, because antibody tests, even the most advanced ones, it’s still an antibody test. It’s still an immune response to an infection.And accurately, you know, some doctors will slam those tests, saying, well. That doesn’t mean you actually have the infection, that just means your body has seen it before, which is a correct statement, kind of. So being able to detect the presence, and even where in the body these infections are was a way huge advancement in the 90s, for sure it’s kind of funny, I think about a conference I went to, and cuz… I’m kind of jumping ahead. Because I ended up developing my own formula, just for this woman and her children, and it worked. And I was like, wow! Their symptoms were gone, all the blood tests came back negative. In those days, we were using the iGenX. Western blot, eventually. And the, what was called a Lyme urine antigen test. I don’t know if you remember that, because it… Only decades later did I meet, the owner of iGenX, Nick Harris. Dr. Deb 9:17Person. And I was like, whatever happened to the Luwat test? Because I took it off the market after a while. He said, honestly, we lost the antigen and couldn’t find it again. Oh, no. David Jernigan 9:27And so… but that was a brilliant test. It was the actual gold standard in those days. Again, the world… it can’t be understated how different the world was in the 90s. Dr. Deb 9:40Yeah. David Jernigan 9:41Towards natural medicine, even. Dr. Deb 9:44Oh, yeah. We think… we think it’s bad now, but, like, when I started, too, I started in the early 2000s, like, we were all hiding under the radar, like, you didn’t market, we would have never been on social media, we didn’t run ads, we didn’t do any. David Jernigan 10:00Right. Dr. Deb 10:01Because the medical boards were coming for us. David Jernigan 10:04Came after me. Dr. Deb 10:05Because I had the word Lime on my page, my website. David Jernigan 10:10You know, not saying that I treat Lyme. Dr. Deb 10:13Hmm? David Jernigan 10:13Yes Dr. Deb 10:15Just talking about mind. David Jernigan 10:16And it’s funny, because, once I had this formula, it was something… and I trained in Germany, in anthroposophical medicine, and they’ve been trained in herbal… making herbal extracts, making homeopathic remedies in the anthroposophical methodology, and I trained with the Hahnemann versions of homeopathy, which is just slightly different. Yeah. And, so I was well-versed with making some of my own formulas by that time. And so, it was really something that I wrote on the bottle, you know, and I had to call it something, so I called it Borreligin, which is still in existence, and it’s still a phenomenal herbal remedy right now. And to my knowledge, it’s the only frequency-matched herbal formula. Maybe still out there. Because unless you knew how to do my testing, the bioresonent scanning, there was no way to actually do frequency matching. Matter of fact, as a really famous herbalist attacked me online, saying, oh, none of these herbs will kill anything. And I’m like, that wasn’t what I was saying. I was saying, back in those days, I was saying, well, if… what would the body need to address these infections?You know, not, like, what’s gonna kill the infections for the body. Dr. Deb 11:38Right. David Jernigan 11:39Right? So it was a phenomenal way, but the LUAT test was amazing because what you’d do is you would give your treatment, like an MD would give an antibiotic for a week, ahead of time. Trying to increase the number of dead spirochetes showing up in your urine one day out of 3 days urine catch. So you’d wake up in the morning, you’d collect your urine 3 days in a row, and any one of those being positive is a positive. But it was a brilliant test because it wasn’t an antibody test. They were literally counting the number of dead pieces of Lyme bacteria in your urine. I mean, it was pretty irrefutable. So I had a grand slam on the… the Western blot on patients, and I’d also have a grand slam on the LUAT, and their medical doctors would say, oh, that doctor in the lab are probably in cahoots change some lab. Dr. Deb 12:38Of course. David Jernigan 12:39That come in. And I still see that today. You know, it’s like, oh my gosh, the better the tests are getting. There’s still a bias if you do your own research. Well, if you happen to be a doctor who loves research. And you’re a clinician, so you actually treat patients who’s gonna write the research study? Well, of course, the doctor who did the study, well, he’s biased, and I’m like, I still can’t influence lab tests. Well, lab tests aren’t everything. People scream over the internet at me. It’s like, well, a negative lab test doesn’t mean anything. I was like… I get that with the old Western blot testing. Dr. Deb 13:16Right. David Jernigan 13:16The more sensitive tests, which are very close to 100%, Sensitivity, and 100% specificity. So, meaning, like, they can… if you have the infection, they’re gonna find it. Dr. Deb 13:30They’ll find it, yeah. David Jernigan 13:31And if they… if you have the infection, they’re going to be able to tell you exactly 100% correctly what kind of infection it is. Back in those days, you couldn’t, you could just count the dead pieces, which was… Dr. Deb 13:43Yeah. David Jernigan 13:43Significant, but It’s funny, because when medicine does that, you know, mainstream medicine that’s backed by all the nice foundations who donate millions of dollars towards the research. Their negative tests are significant, but if you fund your own, Yours isn’t that significant. Dr. Deb 14:04Right, or what if we call something a seronegative autoimmune disease, like lupus or rheumatoid arthritis, because none of the tests are positive, but you have all the symptoms. Here, let me give you this $100,000 a year drug. David Jernigan 14:19Yeah. Dr. Deb 14:19And instead of looking for what might actually be causing the symptoms. That’s all okay, but what we do is not okay. David Jernigan 14:27Right. Yeah, it’s a double standard, and it’s getting better. I want to do… tell the world it is getting better. Some of the dinosaurs are retiring. Dr. Deb 14:36No. David Jernigan 14:37Way for people who are… Are more open-minded to new ideas. But, getting back to that woman, she… that formula that I made just for her and her son, I… She went online. Dr. Deb 14:54Which, I had never been on a news group. David Jernigan 14:58Not even sure I knew what one was, you know? Imagine, I’m kind of that dinosaur that… Cell phones were, like, these really big things with a big antenna sticking out of it, and… Dr. Deb 15:09Nope. David Jernigan 15:10So I thought I was pretty hot stuff, just that I actually had a computer software program that was running my front desk. And even then, it was an Apple IIe computer. Dr. Deb 15:21Right. David Jernigan 15:22Probably be pretty valuable right now if I’d kept it, but… Dr. Deb 15:25Mmm… David Jernigan 15:26It being an antique. But, suddenly people were calling my clinic, because the lady with the twin boys that was well was telling people on these research, I mean, these Lyme disease forums and boards online. And, I started going, oh my gosh, you know, as a doctor, it’s one thing to treat a person in your clinic, it’s a different thing to have your clinic name on the label. Like, we all do, Even now, and you’re supposed to write everything that’s on the label, and… all these guidelines, and I’m like, wow, I need to split this off. I mean, I def… I definitely want to help people, and this is… I was pretty excited about the results we were getting. Pre-treat… Pre-treatment and post-treatment. And, so… that’s where I developed, my nutraceutical business in the 90s called Journey Good Nutraceuticals. My advice to anybody thinking about doing the same thing, don’t put your last name on it. Dr. Deb 16:25– David Jernigan 16:25You know, because anytime negative anything comes out, there goes the Jernigan name, you know, the herbal, you know, there’s just all these, and especially nowadays, with all the bots that are just designed to slam natural medicine. Dr. Deb 16:38Yeah. David Jernigan 16:39And that is out there in a… and just ugly people. Dr. Deb 16:42Or should we just say, people with a different opinion? How’s that? David Jernigan 16:46Yeah. That are being less than supportive. Dr. Deb 16:49But. David Jernigan 16:51It was amazing, because by 1999, I presented my research, my first research, I’d never done research. This is what I would… I would say to a lot of people who go, my doctor did… I don’t know, my doctor doesn’t know what you’re doing, my doctor… I was like going, you know, most doctors don’t do research. They don’t publish anything. Their opinion is their opinion, but they don’t back it up in peer review, right? And so that’s what I always tried to do, was back it up in peer review and publish. And so, in 1999, I presented at the International Tick-Borne Diseases Conference in New York City. I’m telling you, it was like the country boy going to the city, you know, I got my… I got my suit on, and I looked all right, and my booth was wonderful, and all these different things, and it was just a big wake-up call.Because what we had demonstrated… let’s get back to the… and this was what I demonstrated with that first study. was that… A positive LUAC test, that Lyme urine antigen test for my Gen X, was a score of 32. Meaning, one of those 3 mornings urine had 32 pieces in the amount of urine they checked of deadline bacteria spirochetes. Okay? Okay. With antibiotic challenges, a highly positive was a score of 45. Dr. Deb 18:19Wow when I would give one dropper 3 times a day for a week. David Jernigan 18:24Ahead of time, and then do the person’s LUAT test, We were getting scores 100, 200… And at that point, we only had a couple, but we had a couple that were greater than 400. Yeah, dead pieces, where the lab just quits counting. They just said, somewhere over 400, right? Dr. Deb 18:45Yeah. David Jernigan 18:46Which, when the medical system at the conference, you know, I was the only natural doctor in the world that was… had any kind of proof of anything naturally that could outperform antibiotics. Can you imagine? Dr. Deb 18:59Yeah. And… David Jernigan 19:01They were just, oh my gosh, incredulous. They’re like, I’ve given the most… one guy came up to me, and to my face, and he goes, I’ve given the most aggressive antibiotic protocols And I’ve only seen one patient over 100. I was like, that makes this pretty significant, doesn’t it? But, it didn’t just, like, make us take off, because guess what? In Lyme world, if a pharmaceutical antibiotic made you feel horrible. That meant it was working. Dr. Deb 19:28That’s right. We used to, back in the day, if you didn’t herx. And had that horrible die-off reaction, for those of you who don’t know what a herx is, but if we didn’t make you herx, we weren’t doing our job right. David Jernigan 19:40You’re looking for your patients to feel horrible, and sometimes to the level of committing suicide. Dr. Deb 19:46Yes. David Jernigan 19:47So bad. Dr. Deb 19:48Yes. David Jernigan 19:49And I was the first doctor, I think, in the world to start screaming and hollering and saying, stop using the worsening of your patient’s symptoms as a guide to good treatment, because they’re… I wasn’t seeing it with my formulas. Because I was doing a comprehensive program of care. I think I was also one of the first doctors to say, we need to detoxify these people as we’re doing this. And you would sit there and say, well, sure you were. I was like, well, remember, there wasn’t a lot of communication. There wasn’t anybody on the internet saying, do this, do that. And, It was, it was interesting in those days. It was, how do you… How do you help the world heal from these things? That they don’t know they have. So later, I actually had a beautiful booth at a health… a big health expo in Texas, I remember, and I was like, you know, you spend a lot of money on the booth, and… Dr. Deb 20:43Yup. David Jernigan 20:43And you’re thinking about it because you’re funding the whole thing, you say, wow, if I only sell one case, I’ll at least cover my cost. Dr. Deb 20:51Yep. Yeah, you’re great. David Jernigan 20:52And I had this beautiful banner of, like, a blown-up tick’s mouth under microscope. You know those beautiful pictures of, like, all the barbs sticking out, and how they anchor themselves in your skin, and… And, thousand people walking by my booth, and they’re just like, keep walking, because they didn’t know they had Lyme. There was, like, and they had MS, maybe, but they don’t have Lyme, and so they just would keep walking. Nobody even knew. Why would I go to a conference in Texas? And I’m trying to say, no, guys, it’s everywhere. Dr. Deb 21:24Yeah. David Jernigan 21:24And… and everybody, you know, yes, you probably have this, you know, kind of thing. If you’re… if you… are chronically ill, almost, of any kind of way. You know, kind of trying to tell people this was… Again, in Robin’s pathology textbooks, one of the few things that it did tell you about Lyme was that it was called the Great… the New Great Imitator. Because it would imitate up to 200 or more different illnesses. So, it’s been an interesting journey, of… educating people, writing articles, but it was interesting, the lady who I first fixed, Laboratory verified, everything like that, symptoms went away, all that kind of fun stuff. Her children were fine, they’ve been fine for years now. When she went on the newsboards in the Lyme disease support groups, It created a war. Oh my goodness, it was like, how dare you? And, say that something natural might actually help, right? Dr. Deb 22:30Right, exactly. David Jernigan 22:32And, I even had… A… one of those first calls to… with a marketing company at one point, way a long time ago. And the lady got on the phone, the owner of the marketing company goes, I would have blood on my hands if I actually took your clinic on. Yeah, you can’t treat Lyme disease, and… Even the big, big associations that are out there are still largely that way. I mean, they’re getting better, but it’s just like… you know, a lot of the times, it’s herbs are good. Herbs will help. Good, you know, but they’re safe. So, it’s still a challenge to… to… present in mainstream Lyme communities, even. Because there’s this… Fear of doing anything outside of antibiotics. Dr. Deb 23:32Yeah, so let me ask you this. From your perspective. Why do you think so many chronic infections exist these days, like Lyme and the co-infections, Babesia, Bartonella, mold illness? And we talked a little bit about herbs and why they, antibiotics and things like that fail, but let’s talk a little bit about that. David Jernigan 23:53So, it’s fascinating. When I trained in Germany, they said that we, as humanity, has moved away from what they called the inflammatory diseases. You know, in the old days, it was. Lots of high fevers, purulent, pus-generating bacterial infections. And I said, as a society, we have… Dr. Deb 24:14Have shifted from those to what they call cold sclerotic diseases, which are your… David Jernigan 24:21Cancers, your diabetes, your atherosclerosis, your… and they said, we’re starting to see what used to only be geriatric diseases in our children. That’s how bad it’s gotten. We have suppressed fevers, we don’t… we don’t respect the wisdom of the human body. So, you know, the doctors say, step aside, body, I will fix this infection for you with this antibiotic. And so, what we’ve done with the, overuse of antibiotics, and this isn’t me just talking from a natural perspective, this is… Right, it’s everybody around the world is acknowledging. I’ll show you… I could show you a, a presentation, if we can do a screen-sharing situation. Yeah. About the antibiotic situation in the world, because it’s really concerning. But what I would say, and kind of like an advancement forward, is we are seeing mutated bacteria. You know, they talked about… do you remember when they found the Iceman, you know, the… You know, the prehistoric guy that’s… In the eyes, and he had Lyme bacteria. I was like, he had spirochetes, maybe. Dr. Deb 25:33Yeah. David Jernigan 25:33That isn’t a modified, mutated version. That’s just maybe the… Lyme… you know, Borrelia… call it Borrelia something, you know, it’s a spirochete, but what we’re dealing with today. Even under strep or staph, as you know, you know, Pseudomonas aeruginosa, you name it, whatever kind of infection a person has is not the same bacteria that your grandparents dealt with. Dr. Deb 26:01That’s right. David Jernigan 26:32It’s a much mutated, stronger, more resistant to treatment type of thing. So, I think that’s one reason. I think the, It’s great that we’re seeing, you know, Secretary Robert F. Kennedy Jr. bringing awareness to things that Like it or not, yeah, seed oils do create inflammation, and everyone in the natural realm, as you know. Has been trying to say this for probably how long? Dr. Deb 26:35Yeah, 25, 30 years. 20 years each. David Jernigan 26:48Yes. You know, thank goodness for people like Sally Fallon and her beautiful book, Nourishing Traditions, that started you know, Dr. Bernard Jensen’s books way back in the day, Dr. Christopher’s books way back in the day. Dr. Deb 26:48Damn. David Jernigan 26:49You know, all of them were way ahead of their time, saying, by the way, your margarine is only missing one ingredient from being axle grease. Dr. Deb 26:58Yeah. David Jernigan 26:58I think that was Dr. Jensen saying that at one point, probably 50, 60 years ago, I don’t know. Dr. Deb 27:03Yep. David Jernigan 27:04So, we’ve created this monster. We, we live in a very controlled environment, you know, of 72, 74 degrees at all times, we don’t sweat, we don’t have to work that hard, typically. You know, most of us aren’t out there like our ancestors were, so that’s making us more and more… Move towards the cold sclerotic diseases, of which even Lyme disease is, you know, which… Yes, it has inflammation, yes, but as a presentation, it’s very often associated with some of these Cold sclerotic diseases of mankind that we see now. Dr. Deb 27:46You have it. David Jernigan 27:47Yeah. Dr. Deb 27:48So, tell me, what is phage therapy? David Jernigan 27:52Well, may I show you a cool video? Dr. Deb 27:55Yeah, I’d love that. David Jernigan 27:56I did not make this video, this is just one of my favorites, because it’s from the National Institute of Health. Let’s see if I can just… Click the share screen thing. And get that to pop up. That’s not what I’m looking for, but it’s gonna be soon. Let’s go here… Alright, can you see that? Dr. Deb 28:18Yeah. David Jernigan 28:19Okay. Modern medicine faces a serious problem. Thanks in part to overuse and misuse of antibiotics, many bacteria are gaining resistance to our most common cures. Researchers are probing possible alternatives to antibiotics, including phages. So, bacteriophages, or we like to call them phages for short, are naturally occurring viruses that infect and kill bacteria. The basic structure consists of a head, a sheath, and tail fibers. The tail fibers are what mediate attachment to the bacterial cell. The DNA stored in the head will then travel down the sheath and be injected inside the cell. Once inside the cell, the phage will hijack the cellular machinery to make many copies of itself. Lastly, the newly assembled phages burst forth from the bacterium, which resets their phage life cycle and kills the bacterium in the process. Someday, healthcare providers may be able to treat MRSA and other stubborn bacterial infections using a mixture of phages, or a phage cocktail process would be first to identify what the pathogen is that’s causing the infection. So the bacterium is isolated and is characterized. And then there’s a need to select a phage in a process known as screening of phage that are either present in a repository or in a so-called phage library. That allows for many of the phages to be evaluated for effectiveness against that isolated I don’t know, bacterium. Phages were first discovered over 100 years ago by a French-Canadian named Felice Derrell. They initially gained popularity in Eastern Europe, however, Western countries largely abandoned phages in favor of antibiotics, which were better understood and easier to produce in large quantities. Now, with bacteria like these gaining resistance to antibiotics, phage research is gaining momentum in the United States once again. NIAID recently partnered with other government agencies to host a phage workshop, where researchers from NIH, FTA, the commercial sector, and academia gathered to discuss recent progress. NIH… So… That is… That is what phage therapy in… is. in what I call conventional phage. Let’s see, how do I get out of the share screen? Hope you already don’t see it. Dr. Deb 30:58Yep, at the top, there should just be a button. David Jernigan 31:00I don’t. Dr. Deb 31:00Stop sharing, yeah. David Jernigan 31:01So… Conventional phage therapy, as you just saw, is a lot like what it is that we’re doing, only the difference is they’re taking wild phages from the environment. They’re finding phages anywhere there’s, like, a lot of bacteria. And then they isolate those phages, and like he said, the gentleman at the very end said we put them in a library, and so there are banks of phages that they can actually now use, and One of the largest banks that I know of has about 700 different bacteriophages, or phages. In their bank that they can pull from. Dr. Deb 31:43Wow. Do you want to take a guess? David Jernigan 31:46How many bacteriophages they’ve identified are in the human gut, on average? Dr. Deb 31:52Oh my god, there’s gotta be more… David Jernigan 31:53Kinds, different kinds of phages, how many? Dr. Deb 31:56There’s gotta be millions. David Jernigan 31:57Well… In population, there’s… humongous numbers, numbers probably well beyond the trillions, okay? Hundreds of trillions, quadrillions, maybe, even. But in the gut, a recent peer-reviewed journal article said that there were 32,242 different types of bacteriophages that live naturally in your intestines, your gut. Dr. Deb 32:25Boom. David Jernigan 32:2632,000. Okay, so… If you read any article on phage therapy that’s in peer review, almost every single one in the very first paragraph, they use the same sentence. They go, Phages are ubiquitous in nature. They’re ubiquitous in nature. So my brain, when I find… when all this finally clicked together, and when we clicked together 5 years into my research, I could not get it to work for 5 years. I just kept going. But that sentence really got me going. I was, like, going, you know. If you look at what ubiquitous means, it says if Phages were the size of grains of sand. Like sand on the beach. They would completely cover the earth and be 50 miles deep. How crazy is that? Dr. Deb 33:24Wow. David Jernigan 33:25That’s how many phages are on the planet. There’s so many… they outnumber every species collectively on the planet. So, it’s an impossibility in my mind. I went, huh, it’s an impossibility that… You catching a, a sterile Bacteria, it’s almost an impossibility. Since the beginning of time, phages have been needing to use a reproductive host. And it’s very specific, so every kind of bacteria has its own kind of phage it uses as a reproductive host. Because phages are… and this is a clarification I want to make for people. just like in the old days, we were talking about the 90s, I talked to a veterinarian that had gotten in trouble with the veterinary board in her state. Dr. Deb 34:14Back in the old days. David Jernigan 34:16Because she gave dogs probiotics. And the board thought she was giving the dogs an infection so that she could treat them and make money off of the subsequent infection. Dr. Deb 34:28Oh my god. David Jernigan 34:29Nobody actually had heard of good, friendly bacteria in the veterinary world, I guess she said she had gotten in trouble, and she had to defend herself, that, no, I’m giving friendly, benevolent, beneficial bacteria. Okay, to these animals, and getting good results.So, phages… Are friendly, benevolent, beneficial viruses. That live in your body, but they only will infect a certain type of bacteria. So… What that means is if you have staff.Aureus, you know, Staphylococcus aureus bacteria. That bacteria has its own kind of phage that infects it called a staph aureus phage. E. coli has an E. coli phage. Each type of E. coli has its own phage, so Borrelia burgdurferi has its own Borrelia burgdurferi type of phage, whereas Borrelia miyamotoi alright? Or any of the other Borrelia species, or the Bartonella species, or the… you just keep going, and Moses has its own type of phage that only will infect that type of bacteria. So that’s… You know, when you realize, wow, why are we going to the environment Was my thought. Dr. Deb 35:54Yeah. David Jernigan 34:55Trying to find wild phages and put them into your body, and hopefully they go and do what you want them to do. What if we could trigger the phages themselves that live in your body to, instead of just farming that bacteria that it uses as a host, because what I mean by farming is the phages will only kill 40% of that population of bacteria a day. Dr. Deb 36:20Wow. David Jernigan 36:20And then they send out a signal to all the other phages saying, stop killing! Dr. Deb 36:24It’s like. David Jernigan 36:2560% of the bacteria population left to be breeding stock. It’s kind of like the farmer, the rancher, who… he doesn’t send his whole herd to the butcher. Dr. Deb 36:35Right. David Jernigan 36:36Just to, you know, he keeps his breeding stock. He sends the rest, right? So, the phages will kill 40% of the population every day, just in their reproduction process. Because once there’s so many, as you saw in the video, once the phage lands on top of the bacteria, injects its genetic material into the bacteria, that bacteria genetic engine starts cranking out up to 5,200 phages per bacteria. Dr. Deb 37:06I don’t know who counted all those… David Jernigan 37:08Inside of a bacteria, but some scientists peer-reviewed it and put it out there. that ruptures, and it literally looks like a grenade goes off inside of the bacteria. I wish I’d remembered to bring that video of a phage killing a bacteria, but it just goes, oof. And it’s just a cloud of dust. So, you’re breaking apart a lot of those different toxins and things. So… That’s… That was the impetus to me creating what I did. That and the fact that I looked it up, and I found out that phages will sometimes go… Crazy. I don’t know how to say it. Wiping out 100% of their host. And it could be a trigger, like change in the body’s pH levels, it could be electromagnetically done, you know, like, there’s been documentation of… I think it was, 50 Hz, electricity. Triggering one kind of phage to go… Crazy and annihilate its host population. There’s other ways, but I was, like, going, none of those fit me, you know? It’s not like I’m gonna shock somebody with a… Jumper cable or something to try to get phages to… to do that kind of thing. But the fact that it could be done, they can be triggered, they can switch and suddenly go crazy against their population. But what happens when they kill 100% of their host? The phages themselves die within 4 days. Dr. Deb 38:45Hmm. Because they can’t keep reproducing. David Jernigan 38:47There’s nothing to reproduce them, yeah. Dr. Deb 38:49Yeah. Especially… unless they’re a polyvalent phage, that means a phage that can segue and use. David Jernigan 38:54One or two other kinds of bacteria. To, as a reproductive host. But a lot of phages, if not the majority, are monovalent, which means they have one host that they like to use. And so… Borrelia, so… my study that I ended up doing, and I published the results in 2021, And it’s a small study, but it’s right in there at the high end, believe it or not, of phage research. Most phage research is less than 30 people. In the study. But, we did 26 people.And after one month of doing the phage induction that I invented, which only… Appears to only, induce or stimulate the types of phages that will do the job in your body. I don’t care what kind of phage it is. I don’t care if it’s a Borrelia phage, it may be a polyvalent phage that normally doesn’t use the Borrelia burgdurferi as its number one. Host, but it can. To go and kill that infection. And the fascinating thing is, there was a brand new test that came out at the same time I came out with the idea, literally the same weekend they presented. Dr. Deb 40:1511. David Jernigan 40:15ILADS conference in Boston in 2019. It was called the Felix Borrelia phage Test. So the Felix Borrelia phage test. Because Borrelia are often intracellular, right, they’re buried down in the tissue, they’re not often in the blood that much. And therefore, doing a blood test isn’t really that accurate. But you remember how there’s, like, potentially as many as 5,200 phages of that type erupt from each bacteria when it breaks apart. It’s way easier to detect those phages, because they’re now circulating, those 52, as you saw in the video. 5,200 different phages are now seeking out another Borrelia that they can infect. And so, while they’re out in circulation, that’s easy to find in the bloodstream. So, 77% of the people, so 20 out of 26, were tested after a 2-week period. After only a 4-day round of treatment. Because according to my testing, remember, I can actually test adjunctively to see if I can find any signatures for those kinds of bacteria. And I couldn’t after 4 days, so we discontinued treatment and waited Beyond the 4 days that would allow the phages themselves to die, so we waited about a week and a half.And redid the test. And 77%, so that 20 out of 26 of the people, were completely negative. Dr. Deb 41:50Wow. David Jernigan 41:52Which, you go, well, it’s just a blood test. Well, no, we actually had people that were getting better, like, they’d never gotten better before. We had one woman who was wheelchair-bound, and in two weeks was able to walk, and even ultimately wanted to work for my clinic. I’m just, like, going… Dr. Deb 42:07I didn’t want to write about all that. I wanted to write about the phages. I was like… David Jernigan 42:12article, I probably should have put some of those stories, because, Critics would say, well, you got rid of the infection, maybe, but… Did you fix the Lyme disease? Well, that’s… there’s two factors here that every doctor needs to understand. There’s the infection in chronic illness, there’s the infection, and then there’s the damage that’s been done. Because sometimes I have these people that would come in and say, well, Dr. Jernigan, it didn’t work for me, I’m still in the wheelchair. And I’m like, no, it worked. Repeat lab test over months says it’s gone, it’s gone, it’s gone. It’s like, we would follow, and 88% of the people we followed long-term were still negative, which is amazing to me. Dr. Deb 42:56And then they have to repair the damage. David Jernigan 42:59It’s the damages why you still have your symptoms. And that’s where the doctor has to get busy, right? Dr. Deb 43:06Right David Jernigan 43:06They were told erroneously by their doctor that originally treated them that they’d be well, they’d get out of the wheelchair, if he could actually kill all these infections. Dr. Deb 43:15It’s not true. David Jernigan 43:16Unless it’s caught early. So I love the analogy, and I’ve said it a thousand times.that Lyme disease and chronic infections are much like having termites in the wood of your house. If you find the termites early, then yeah, killing the infection, life goes back to normal, the storm comes and your house doesn’t fall down. But if it’s 20 years later. Killing the termites is still a grand idea. Right. But you have the damage in the wood that needs to be repaired as well. All the systems… when I talk about damage to the wood, I mean, like. All the bioregulatory aspects of the body, how it regulates itself, all the biochemical pathways, the metabolic pathways we all know about, getting the toxins that have been lodged in there for many years, stopping the inflammatory things that have been running crazy. Dealing with all those cytokines that are just running rampant through the body, creating this whole MCAS situation. Which are largely… Dr. Deb 44:21Coming from your body’s own immune cells called macrophages, which are not even… David Jernigan 44:26It’s not… a virus at all, it’s part of the immune system, it’s like a Pac-Man, and research shows that especially in spirochetes. There is no toxin. Now, I wrote 4 books. I think I wrote the very first book on the natural treatment of people with Lyme disease back in the 90s. Why did I write that? Not because I wanted to be famous, it’s a tiny book, actually, the first one was.I was just trying to help people get out of this idea that you will be well when you kill all the bugs. I was saying, it’s… you need to be doing this. If you can’t come to my clinic, at least do this. Try to find somebody that will do this for you. And that ultimately led to a bigger book.as I kept learning more, and I was like, going, well, okay, now at least do this amount of stuff. And you need to make sure your doctor is handling this, this, this, and this. And so, the third book was, like, 500 and something pages long. And then the fourth book was 500 and something pages long, and now they’re all obsolete with the whole phage thing, because this just rewrites everything. Dr. Deb 45:34Yeah. David Jernigan 45:34It’s pretty fascinating. Dr. Deb 45:37Do you think the war on bugs, mentality created more chronic illness than it solved? David Jernigan 45:44Because of the tools that doctors had to use, yes. We’re a minority, we’re still a minority, you and I. Dr. Deb 45:54Yep. Our doctoring… David Jernigan 45:56Methods I never had, and you’d never… maybe you did, but I’d never had the ability to grab a prescription pad and write out a prescription. I had to figure out, how do I get… and this was… and still my guiding thing, is like, how do I identify, number one, everything that can be found that’s gone wrong in the human body. And what do I need to provide that body? Like, the body is the carpenter. That has to do the repair, has to regenerate, has to do everything, has to get… everything fixed right? We can’t fix anything. If you have a paper cut, there isn’t a doctor on the planet that can make that go away. Dr. Deb 46:38Right. David Jernigan 46:39Of their own power, much less chronic illnesses. So, all the treatments are like the screws, saws, hammers, you know the carpenter must be able to use. So a lot of the time, doctors are just throwing an entire Home Depot on top of the carpenter. In the form of, like, bags of supplements, you know, hundreds of supplements, I’ve seen patients walk in my door with two suitcasefuls. And they were taking 70 bottles, 65 to 70 bottles of supplements, and I’d be just like, wow, your carpenter who’s been working for 24 hours a day, 7 days a week. He’s exhausted. There’s chaos everywhere, you don’t know where to. Dr. Deb 47:22Starting. David Jernigan 47:22He goes, you want me to do what with all this stuff? Dr. Deb 47:25Yep, I’ve seen the same thing. People… thousands, you know, several thousand dollars a month on supplements, and not any better. But they’re afraid to give up their supplements, too, because they don’t want to go backwards, either, and… there’s got to be a better way on both sides, the conventional side and the alternative side, although you and I don’t say it’s alternative, that’s the way medicine should be, but… David Jernigan 47:48Right. Dr. Deb 47:49We have to have a good balance on both sides. David Jernigan 47:52And I will say, too, in defense of doctors using a lot of supplements, I do use a lot of supplements. Dr. Deb 47:57Yeah, I do too. David Jernigan 47:58but I want to synergize what I’m giving the patient so that the carpenter isn’t overwhelmed and can actually get the job done. Like, everything has to work harmoniously together, so it’s not that… It’s not the number of supplements, and why would you need a lot of supplements? Well, because every system in your body is Messed up. My kind of clientele for 30 years. Our clientele, yours and mine. Dr. Deb 48:25Yeah. David Jernigan 48:26They have been sick, For decades, many of them. Dr. Deb 48:31Yeah. David Jernigan 48:31And if they went into a hospital, they honestly need every department. They need endocrinology, they need their kidney doctor, they need their… They’re a cardiologists, they need a neurologist, they need a rheumatologist. I mean, because none of those doctors are gonna deal with everything. They’re just gonna deal with one piece of the puzzle. And if they did get the benefit of all the different departments they need, yeah, they’d go out with a garbage bag full of stuff, too. Dr. Deb 48:57Hey, wood. David Jernigan 48:58Only, they’re not synergized. They don’t work together. You’re creating this chemistry set of who knows how much poison. And I want to tell your listeners, and I mean, you probably say this to your patients as well. There is a law of pharmacy that I learned eons ago, and it applies to natural medicine, too. Dr. Deb 49:21Yep. David Jernigan 49:22But the law says every drug’s primary side effect Is its primary action. So, if you listen to TV, you can see this on commercials. I love… I love listening to these commercials, because I’m like, wow. let’s… let’s… I don’t want to say I’ve named Brandon. I don’t know if that’s…Inappropriate to name a name brand, but let’s just say you have a pharmaceutical that is for sleep. After they show you this beautiful scene of the person restfully sleeping and everything like that, they tell you the truth. It’s like, this may cause sleepiness… I mean, sleeplessness. Dr. Deb 50:04Yeah. David Jernigan 50:04Found insomnia. Dr. Deb 50:06And headaches, and diarrhea. David Jernigan 50:08All the other things, and if it’s an antidepressant, what does the commercial do after it finishes showing you little bunny foo-foo, jumping through a green, happy people? They tell you, this may create depression, severe depression, and suicidal tendencies, which is the ultimate depression. So, I want everyone to understand you need to figure out what your doctor’s tools are that they’re asking you to take, and they’re wanting you to take it forever, generally in mainstream medicine, right? In the hospitals and everything. They don’t say, hey, your heart has this condition, take this medicine for 3 months, after which time you can get off. Dr. Deb 50:48Yep. David Jernigan 50:49not fixing it, right? So… That, on a timeline, there is a point, if it was truly even fixing anything. That you… it’s done what it should do, and you should get off, even if it’s a natural product. It’s just like. Dr. Deb 51:03Right David Jernigan 51:03It’s done what it should do, and you should get off, but instead. you go through the tree… the correction and out the other side, and that’s where it starts manifesting a lot of the same problems that it had. So, anti-inflammatories, painkillers, imagine the number one side effects are pain inflammation. So, the doctor says, well. If you say, hey, I’m having more pain, what does he do? He ups the dosage. And if he… if that doesn’t work, if you’re still in a lot of pain, which he would be, he changes it to a more powerful thing, right? But it starts the cycle all over again. So when you ask me, it’s like, why are we having so much chronic illness? It’s because of the whole philosophy. is the treatment philosophy of mainstream medicine that despises what you and I do. Because we’re… our philosophy from the start is the biggest thing. It’s like… We’re striving for cure. That dirty four-letter word, cure, we’re not even supposed to use it. And yet, if you look it up in Stedman’s Medical Dictionary, it just means a restoration of health. Remission. Everyone’s like, oh, I’m in remission. I’m like, remission is a drug term. It’s a medical term. Again, look it up in a medical dictionary. It is a pharmaceutical term for a temporary pause Or a reduction of your symptom, but because it’s just… symptom suppression, it will come back. It’s… remission is great, I suppose, in… At the end of, like, where you’ve exhausted everything, because I can’t fix everything, I don’t know about you. Dr. Deb 52:41No, I can’t either, yeah. David Jernigan 52:43you know, on my phone consults, I try to always remind people, as much as I get excited about my technologies gosh, I see so much opportunity to fix you. I always try to go, please understand, I’m gonna tell you what most doctors may not tell you on a phone consultation. I can’t fix everything. Dr. Deb 53:03Yeah. David Jernigan 53:03For all of my tricks, I can’t fix everything. Not tricks, but you know, all my technologies, and all my inventions. Phages, too. They are a tool. You know, antibiotics. I think I wrote a blog one time, it should be on my website somewhere, that says, Antibiotics do not… fix… neurological disease, or… I don’t know, something like that. You know, you’re using the wrong tool. I mean, it does what it does. Dr. Deb 53:32Yeah, you’re using a hammer to do what a screwdriver needs to. David Jernigan 53:35Yeah, you know, it’s like it’s… And yet, you can probably tell her… that you’ve had patients, too, that they go, Dr. Jernigan. My throat was so sore, and as soon as I swallowed that antibiotic. I felt better, and I’m, like, going… How long did it take? Oh, it was immediate! I was like, dude, the gel cap didn’t even have time to dissolve, I mean… Dr. Deb 53:58SIBO. David Jernigan 54:00But, it’s not going to repair the tissues that were all raw. kind of stuff. So, I mean, that ulceration of your throat that’s happening, the inflammation, there’s no anti-inflammatory effect of these things. So, I digress a little bit, but phages, too… I wrote an article that’s on the website, that’s setting healthy expectations for phages, because they want… we can see some amazing things happen, things that in my 30 years, I wish I had all my career to do over again, now having this tool. It’s just that much fun. I… when doctors around the country now are starting to use our inducent formulas, there’s, 13 of them now, formulas. For different broad-spectrum illness presentations. I tell them all the same thing, I was like, you are gonna have so much fun. Dr. Deb 54:53That’s exciting. Women. David Jernigan 54:54Winning is fun, you know? I was like. You know, mainstream medicine may never accept this, I don’t know. I feel a real huge burden, though, to do my best to follow a, very scientific methodology. I’ve published as much as I can publish at this time by myself. I never took money from the… the sources that are out there, because what do they do? They always come… money comes with strings. Dr. Deb 55:22Yes, it does. David Jernigan 55:23I don’t trust… I don’t trust… I mean, if you listen to the, roundtable that Our Secretary Robert F. Kennedy Jr. Dr. Deb 55:35Yeah. David Jernigan 55:36On Lyme disease last week the first couple of speakers were, like, pretty legit. I mean, all of them were legit, but I mean, they were, like, senators and congressmen or something like that, I think. And then you have… RFK Jr. himself, who’s legit. Yeah they were fessing up to the fact that, yes, they were suppressing anything to do with Lyme. Dr. Deb 56:00Yeah. David Jernigan 56:00Our… our highest levels of, marbled halls and pillars and… of medicine were doing everything the way I thought they were. They were suppressing me. I was like, how can you ignore the best formulas ever, and still, I think Borreligen, and now, induced native phage therapy are still, I believe, I don’t… I’ve never seen it, I could be wrong. The only natural things that have been documented in a medical methodology. Dr. Deb 56:34Hmm in the natural realm. I mean, all the herbs that we talk about. David Jernigan 56:39You know, there’s one that was really famous for a while, and it said, we gave… so many patients. This product, and other nutritional supplements. And at the end, X number of them were… dramatically better. That’s not research. Dr. Deb 56:57Right. That’s observation. David Jernigan 56:59The trick there was we gave this one thing, and then we gave high-dose proteolytic enzymes, we gave high dose this, we gave high dose that, but at the end of the study, we’re going to point back at the thing we’re trying to sell you as being what did it. Dr. Deb 57:12Which is what we do in all research, pretty much. David Jernigan 57:15Well… Dr. Deb 57:16tried to… David Jernigan 57:17Good guys, I hope. Dr. Deb 57:18Do the way we want, right? In… in conventional… David Jernigan 57:22Yeah. Dr. Deb 57:22Fantastic David Jernigan 57:23Very often, yeah, in conventional medicine, definitely. Yeah. And, it’s kind of scary, isn’t it, how many pharmaceuticals are slamming us with, because they’re… Dr. Deb 57:33Okay. David Jernigan 57:34There’s a new one on TV every day, and there’s. Dr. Deb 57:36Every day, yes. David Jernigan 57:37It’s like, who comes up with these names? They’re just horrible. Dr. Deb 57:40Yeah, you can’t pronounce them. David Jernigan 57:41I want to be a marketing company and come up with some Zimbabwehika, or something that actually they go with, and I’m like, I just made a million bucks coming up with it. I’ll be glad when that’s not on the TV anymore, which… Oh, me too. Me too. Dr. Deb 57:54Dr. Jaredgen, this was really wonderful. What do you want to leave our listeners with? David Jernigan 58:00Well, you know, everyone’s calling for a new treatment. Dr. Deb 58:05Yeah. You bet. David Jernigan 58:08I have done everything I can do to get it out there, scientifically, in peer review, so that if you want to look up my name. Dr. Deb 58:16I published an open access journal so that you didn’t have to buy the articles. Like, PubMed, you have to be a member. If you want to look at a lot of the research, you have to buy the articles. David Jernigan 58:26I’ve done everything open access so that people had access to the information. I honestly created induced native phage therapy to fix my own wife. I mean, I… I was… I used to think I could actually fix almost anything. Gave me enough time. And, I could not fix her. You know, the first 10 years, she was bedridden. Dr. Deb 58:49Wow. David Jernigan 58:50People go, oh, it’s easy for you, Dr. Jernigan, you’re a doctor. Dr. Deb 58:54Oh yeah, right? Yeah. David Jernigan 58:56Oh my gosh, how many tears have been shed, and how much heartache, and how much of this and that. I mean, 90% of our marriage, she was in, bed, just missing Christmas. All the horror stories you hear in the Lime world, that was her, and I could not get her completely well. And, she’s a very discerning woman. I say that in all my podcasts, because it’s. Dr. Deb 59:19Just… David Jernigan 59:16Amazing. It’s like, every husband, I think, should want a wife that’s… Always, right? Not that you surrender your own opinion, but it’s like, it’s… it was literally, I don’t know what, 6 months before the ILADS conference in Boston in 2029… in 2019 that She said, are you going to the ILADS conference this year? And I’m like, I’ve been going for, like, 15, 20 years, however long it’s been going on, and I was like, I’m not gonna go to this one. And, 3 days before the conference, she says, I think you should go. And I go, okay. Like I say, she’s generally right. And that… I bought a Scientific American magazine at the newsstand in the Nashville airport. Started reading a story about phages in that that copped that edition of the Scientific American, and It was a good article, but it wasn’t super meaty, you know. very deep on those, but I just was stimulated. Something about being at elevation. Dr. Deb 1:00:02Yeah. Your own mountains, I don’t know, I get all inspired. David Jernigan 1:00:25And I wrote in the margins and highlighted this and that until it was, like, ultimately, I spent the entire conference hammering this out. And it worked. And it’s been working, it’s just amazing. It’s… We’re over 200 different infections that we’ve… we’ve clinically or laboratory-wise documented. There’s a new test for my GenX called the CEPCR Lyme Panel. like, culture. 64 different types of infections, and I believe right now the latest count is something like 10 for 10 were completely negative. Dr. Deb 1:01:03Wow. David Jernigan 1:01:03These chronically infected people. And so, that hadn’t been published anywhere. So, in my published article, remember I was talking about that 20 out of the 26 were tested as negative for the infection? That doesn’t mean they’re cured, okay? Remember, they’re chronically damaged. That’s how we need to look at it. Dr. Deb 1:01:23funny David Jernigan 1:01:24damaged. You’re not just chronically infected. And, but with 30-day treatment.24 out of the 26 were tested as negative. Dr. Deb Muth 1:01:34That’s amazing. David Jernigan 1:01:35So 92% of the people were negative.Okay? The chances of that happening, when you run it through statistical analysis.The chances… when you compare the results to the sensitivity percentages, you know, the 100% specificity and 92% sensitivity of the…Of the lab testIt’s a 4.5 nonillion to 1 chance that it was a fluke. Isn’t that amazing? Now, nearly… I’m not even sure how many zeros that is, but it’s a lot. Dr. Deb Muth 1:02:08That’s is awesome. David Jernigan 1:02:09Like, if I just said, well, it’s a one in a million chance it was a fluke.Okay.So, lab tests don’t lie. You’re not done, necessarily, just because you got rid of the infections. Now that formula for Lyme has grown to be 90-plusmicrobes targeted in the one formula. So, we figured out we can actually target individually, but collectively, almost like an antibiotic that’s laser-guided to only go after the bad guys that we targeted.So, all the Borrelia types are targeted, all the Babesias, for,the Bartonellas, the anaplasmosis, you name it, mycoplasma types are all targeted in that one formula, because I said.Took my collective 30 years of experience and 15,000 patients.that I would typically see as co-infections and put them into that one formula, so…When we get these tests coming back that are testing for 64, it’s because of that.So, there’s a lot of coolnesses that I could actually keep going and going. Dr. Deb Muth 1:03:15That’s exciting. David Jernigan 1:03:15I love this topic, but I thank you for letting me come on. Dr. Deb Muth 1:03:18Thank you for joining us. How can people find you? David Jernigan 1:03:22Two ways. There’s the Phagen Corp company that is now manufacturing my formulas.That is P-H-A-G-E-N-C-O-R-P dot com. Practitioners can go there, and there’s a practitioner side of the website that’s very beefy with science, and… and all the formulas that were used, what’s inside of all the formulas, meaning what microbes are targeted by each one. Like, there’s a GI formula, there’s a UTI formula, there’s a SIRS formula, there’s a Lyme formula, there’s a central nervous system type infection formula, there’s… And we can keep going, you know, SIBO, SIFO formula, mold formula… I mean, we’ve discovered so many things that I could just keep going for hours, and… Dr. Deb Muth 1:04:05Yeah. David Jernigan 1:04:06About the discoveries, from where it started in its humble beginnings, To now, so… There’s another way, if you wanted to see our clinic website, is Biologics, with an X, so B-I-O-L-O-G-I-X, Center, C-E-N-T-E-R dot com. And, if somebody thinks they want to be a patient and experience this at our clinic, typically we don’t take just Easy stuff. All we see is chronic.Chronic cases from all over the world. Something like 96% of our patients come from other states and countries. And typically, I’ve been close to 90% for my whole career.About 30-something percent come from other countries in that, so… we’ve gotten really good and learned a lot in having to deal with what nobody else knows what to do with. But if you do want to do that, you can contact us. And, if you… If you don’t get the answers from my patient care staff, then I do free consultations. With the people that are thinking about, whether we can help them or not. Dr. Deb Muth 1:05:13Well, that’s excellent. For those of you who are driving or don’t have any way of writing things down, don’t worry about it, we’ve got you. We will have all of his contact information in our show notes, so you will be able to reach out to him. Thank you again for joining me. This has been an amazing conversation. David Jernigan 1:05:30Thank you, I appreciate you having me on. It was a lot of fun. The post Episode 252 – Induced Native Phage Therapy (INPT) & advanced natural therapies first appeared on Let's Talk Wellness Now.

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[Best of] Phages regulate bacteria growth on earth

Science Stories

Play Episode Listen Later Dec 12, 2025 27:10


Today's story is a good example of how little we know about biology and life, and how we can use our knowledge to better fight diseases and environmental threats. We are going to talk about bacteriophages or just fages. These are small viruses which attack bacteria. The story is literally about life and death and most organisms on earth are being killed every week. We have covered this topic before but, but in this podcast we will go deeper into the substance and ask one of the current frontier researchers from the biocomplexity group at the Niels Bohr Institute in Copenhagen Namiko Mitarai Japan.

The Science Show -  Separate stories podcast
Phage – part of the fight against antibacterial resistance

The Science Show - Separate stories podcast

Play Episode Listen Later Oct 11, 2025 5:11


Phages are viruses which attack specific bacteria. 

Health Check
Can bacteria-eating viruses be used to fight superbugs?

Health Check

Play Episode Listen Later Jul 2, 2025 26:28


Phages are viruses that only infect bacteria. How might they help us tackle antimicrobial resistance? Franklin Nobrega and Esme Brinsden from the University of Southampton explain how their citizen science project that collects samples from around the globe is building a library of these bacteria-fighting viruses. How can ultrasound find new targets to treat apathy in Parkinson's disease? Tom Gilbertson and Isla Barnard from the University of Dundee explain all. Also on the show, EntangleCam is using quantum physics to improve what we can see inside the human body and how breast cancer is diagnosed. Plus, surgical gloves with special sensors that improve precision and sensitivity in obstetrics and surgery. Carmen Fernadez fills us in on the engineering behind them and Dawn Parris tells us about her research into their use in practice. Join us for a special episode of Health Check from The Royal Society's annual Summer Science Exhibition in London. Claudia Hammond is joined by BBC health and science correspondent James Gallagher to take a look and compete in scientific games to see who this year's champion is. Presenter: Claudia Hammond Producer: Hannah Robins Assistant Producer: Katie Tomsett Studio Manager: Phil Lander

Relax with Meditation
How to kill dangerous bacteria like the Superbugs?

Relax with Meditation

Play Episode Listen Later Apr 1, 2025


 Finally, there is a remedy, even invented 100 years ago…Called Phages bacterial treatmentWhat is Phage Therapy?Phages, formally known as bacteriophages, are viruses that solely kill and selectively target bacteria. They are the most common biological entities in nature and have been shown to effectively fight and destroy multi-drug resistant bacteria. Namely, when all antibiotics fail, phages still succeed in killing the bacteria and may save a life from an infection.The phage virus needs a host where it can spread its eggs. The host is that specific bacteria that you want to kill. The phage virus injects its eggs inside that bacteria. The eggs grow to that phage virus and kill the bacteria… Thousands of new phage viruses search for the correct bacteria …  Imagine that… After a short time, all the bacteria are killed. The problem is to find the correct phage virus to kill that specific bacteria or even the Superbug. And that can be done because you find the phage virus everywhere… At least in garbage places or water filtering systems.  The main concern for all of us now is the alarming rate of increasing 'superbugs' that are resistant to most — if not all — antibiotics, as well as the impact they will have on human health and the longevity of life. These issues, combined with a lack of regulation to approve the process of phage therapy for anything less than an absolute, no-alternative emergency, pose a serious concern for us. We hope that through our work here at PATH, we can make this treatment more widely available to save lives where no other treatments could.My Video: How to kill dangerous bacteria like the Superbugs? https://youtu.be/H_BSLJ8bzfQMy Audio: https://divinesuccess.net/wp-content/uploads/2021/Podcast4/How-to-kill-dangerous-bacteria-like-the-Superbugs.mp3

One Thing with Dr. Adam Rinde
Episode 112. Unlocking the Microbiome: Martha Carlin's Journey into Gut Health & Parkinson's

One Thing with Dr. Adam Rinde

Play Episode Listen Later Feb 22, 2025 46:35


Parkinson's and gut health: The connection you need to understand! Uncover practical steps you can take today to support a healthier gut environment and improve overall well-being for both patient and caregiverIn this episode of The One Thing Podcast, Dr. Adam Rinde dives deep into the fascinating world of the microbiome with Martha Carlin, a citizen scientist, entrepreneur, and microbiome expert. After her husband's Parkinson's diagnosis, Martha took a radical approach—teaching herself chemistry, microbiology, and systems biology to uncover the connection between gut health and neurological conditions. Martha is the founder of **The Biocollective** and **BiotiQuest**  @biotiquest4511  , and her research has led to groundbreaking discoveries in gut health, probiotics, and disease prevention. In this episode, she shares insights on how the microbiome impacts brain health, digestion, and overall well-being, including how gut bacteria might be a key player in Parkinson's disease.

BEaTS Research Radio's Podcast
Unseen Allies: Skin-Dwelling Viruses that Kill Harmful Bacteria

BEaTS Research Radio's Podcast

Play Episode Listen Later Dec 5, 2024 15:37


In this episode, Celina Tanbari from the University of Ottawa interviews Dr. Adam Rudner about the fascinating world of bacteriophages—viruses that target and kill bacteria. Dr. Rudner is the coordinator of the University of Ottawa's Phage Hunters program, a member of the SEA-PHAGES and SEA-GENES programs, and an Associate Professor in the Department of Biochemistry, Microbiology, and Immunology. Dr. Rudner shares with us his expert opinion on a study that isolated bacteriophages from human skin to kill infection-causing bacteria. The discussion delves into the therapeutic potential of phages, their involvement in biofilms and lysogeny, and the challenges associated with utilizing phages in medicine. This episode was produced and written by Emma Etchells Foisy, hosted by Celina Tanbari, and audio edited by Sam Rogers. Copyrights are reserved to BEaTS Research Radio and the University of Ottawa.If you are interested in learning more about the paper we discussed today, you can find it through the following link: https://pmc.ncbi.nlm.nih.gov/articles/PMC10117716/Learn more: https://www.uottawa.ca/faculty-medicine/dr-adam-rudner 0:03 | BEaTS and host introduction.0:38 | Introducing Dr. Rudner.1:05 | What are bacteriophages?1:41 | Phages as a possible solution to antibiotic-resistant bacteria 2:41 | What are biofilms, and how do they affect bacterial infections?5:01 | Phage BE01 and how lysogeny can affect phage therapy.8:52 | Phage BE04 and the potential of phages in replacing antibiotics. 10:55 | Squashing the stigma, phages only attack bacteria.12:35 | Potential challenges with phage therapy. 14:08 | Dr. Rudner's take-home message. 14:36 | Thank yous and credits!Soundtrack, Chillout by AudioCoffee | https://www.audiocoffee.net/Music promoted by https://www.chosic.com/free-music/all/Creative Commons CC BY-SA 3.0https://creativecommons.org/licenses/by-sa/3.0/

Science Friday
Bacteriophages Lurk In Your Bathroom, But Don't Worry

Science Friday

Play Episode Listen Later Nov 20, 2024 18:00


It sounds like something from an advertisement for bathroom cleaner: Researchers found over 600 different viruses, most of which are new to science, in samples taken from showerheads and toothbrushes. The viruses, however, are unlikely to affect humans. They are bacteriophages, a type of virus that preys on bacteria. The expedition into bathroom biodiversity was recently published in the journal Frontiers in Microbiomes.Around a hundred years ago in the former Soviet Union, there were major efforts to develop bacteriophages for medical use. The approach really didn't catch on in Western countries, overshadowed there by the rise of conventional antibiotics like penicillin. But with some diseases developing resistance to those conventional antibiotics, there's been increased interest in phages as part of an antibacterial toolkit.Dr. Erica Hartmann, an associate professor in the department of Civil & Environmental Engineering at Northwestern University, joins Ira to talk about what researchers found when they took a close look at a collection of bathroom samples, and how phage research has advanced in recent years.Transcript for this segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Science Stories
Phages regulate bacteria growth on Earth

Science Stories

Play Episode Listen Later Sep 13, 2024 27:10


Today's story is a good example of how little we know about biology and life, and how we can use our knowledge to better fight diseases and environmental threats. We are going to talk about bacteriophages or just fages. These are small viruses which attack bacteria. The story is literally about life and death and most organisms on earth are being killed every week. Senior researcher Namiko Mitarai from the biocomplexity group at the Niels Bohr Institute in Copenhagen Namiko Mitarai is being interviewe by Science Journalist Jens Degett.

Short Stories of Bacteria
Ep. 67 - The Problem With Phages

Short Stories of Bacteria

Play Episode Listen Later Jul 16, 2024 16:02


With all the hubbub around phage therapy, why hasn't this replaced antibiotics entirely? We'll touch on some of the reasons in today's episode..Music by Muzaproduction from Pixabayhttps://www.instagram.com/sciencewithdr_k/ https://www.youtube.com/channel/UC2EttB4pjdZ4WrU3-z4RqPghttps://www.nature.com/articles/s41564-024-01705-xhttps://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00612-5/abstracthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278648/https://www.nature.com/articles/s41591-021-01403-9 https://www.nature.com/articles/d41586-023-02209-0

This Week in Microbiology
312: Cry Havoc!, and Let Slip the Phages of Healing

This Week in Microbiology

Play Episode Listen Later Jun 28, 2024 53:14


TWiM explains a new mechanism for preventing lysogeny through temperate phage-antibiotic synergy, and Salmonella expansion in the murine gut dependency on aspartate derived from reactive oxygen species-mediated microbiota lysis. Hosts: Michael Schmidt, Petra Levin and Michele Swanson. Become a patron of TWiM. Links for this episode Temperate phage-antibiotic synergy (mBio) Salmonella expansion dependent on aspartate (Cell Host Micr) Arrowsmith by Sinclair Lewis (Wiki) A Genetic Switch by Mark Ptashne Lysis timing and bacteriophage fitness (Genetics) HK97 capsid assembly (Ad Exp Med Biol) Mode of action of fluoroquinolones (Drugs) Salmonella a foodborne pathogen (CDC) Freeman Hrabowski Scholars Program (HHMI) Sam Kaplan - 30 years of Microbiology (McGovern Medical School) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

Alloutcoach Tim
PERSONALIZED MEDICINE WITH PHAGE THERAPY TO TARGET PATIENTS AND BACTERIA

Alloutcoach Tim

Play Episode Listen Later Jun 24, 2024 27:25


In this Part 2 of the Alloutcoach podcast episode focused on phage therapy to fight infections and antimicrobial resistance, I spoke to the Chief Physician at the globally leading center of excellence of an alternative, effective treatment approach to antibiotics, Dr. Dea Nizharadze at the Eliava Phage Therapy Center (EPTC) based in Tbilisi, Georgia. She explains the basic principles of phage treatments, its unique qualities, advantages and real-world clinical examples of methods and types of patients and infections this personalized therapy specifically targets. 0:00 Episode Introduction 1:42 Why the Republic of Georgia is a global leader in phage therapy 2:39 How phage therapy works in bacterial infections?Eliava Phage Therapy Center (EPTC) was founded in 1923 by Professor George Eliava who had collaborated with Felix D'Herelle, who had discovered phages, and while most other countries turned to antibiotics only, it is the only institution in the world that has continued to research bacteriophages without a pause of even one day since its inception and therefore collected the greatest research and real-world clinical experience with phages. 5:34 How do phages work to eradicate or stop further growth of bacteria? Phages are biological "weapons" against bacteria, namely viruses that target specific microbes only, without destroying the "good" bacteria or microbiota. They are naturally occurring substances and have no safety concerns. In some patients with antimicrobial resistance phage therapy enables improvement in sensitivity. 10:42 Synergistic effect of phage combination therapy with antibiotics 11:58 Phage Therapy Doisng and Success Factors 15:14 Length of phage treatmentIn chronic infections phage therapy may divided into 3 stages and last 15-20 days, and varies by nature and severity of disease. Patient treatment includes days off therapy, or holidays, however, bacterial analysis is continued and patient condition is monitored throughout the entire course of treatment. Success of therapy is indicated when bacterial titers and virulence decrease or bacteria are eradicated. Patient's objective and subjective signs and symptoms often vary throughout response to therapy. 16:42 Phage Product Variability and Market Availability How do we ensure educating patients to access the correct, most appropriate therapy for their infections 17:35 Multi-disciplinary personalized team care and telemedicine 19:53 Steps for patients outside of Georgia to access phage therapy via telemedicine? 24:04 Affordability and access to phage treatments 25:23 How to contact Eliava Phage Therapy Center

The Skiffy and Fanty Show
772. Microbiology with Daniel Haeusser, the Scientist

The Skiffy and Fanty Show

Play Episode Listen Later May 23, 2024 73:37


Phages, microbes, and scientific conundrums, oh my! Shaun Duke turns the tables on Daniel Haeusser to ask a metric ton of questions about microbiology. Why? Because Daniel is one of those legit scientists. Join us for a wide ranging and utterly wild conversation about bacteria, viruses, micro-whatsits, and speculative wonders! Thanks for listening. We hope […]

scientists microbiology phages because daniel shaun duke
projectsavetheworld's podcast
Episode 604 Anti-microbial Resistance

projectsavetheworld's podcast

Play Episode Listen Later May 17, 2024 57:04


Laura Kahn is a leader in the field of "One Health," which studies the interdependence of human, veterinary, and environmental health issues. She authored a book about the increasing resistance of microbes to antibiotics and antiviral medications, mainly because of over-exposure. For the video, audio podcast, transcript, and comments: https://tosavetheworld.ca/episode-604-anti-microbial-resistance.

Voices of The Walrus
The resistance is coming

Voices of The Walrus

Play Episode Listen Later May 5, 2024 17:37


Antibiotics may become useless in our lifetime. Doctors are looking to the past for help

Rick Dayton
Fighting drug-resistant bacteria

Rick Dayton

Play Episode Listen Later Feb 14, 2024 9:14


Drug-resistant bacteria has long been a problem for doctors in hospitals around the world. Today, a case study by University of Pittsburgh School of Medicine scientists was published in the American Society for Microbiology journal mBio. The senior author on the paper is Dr. Daria Van Tyne. She explained to Rick Dayton how they found success with Phages in combination with antibiotics. 

This Week in Virology
TWiV 1079: Rock of phages

This Week in Virology

Play Episode Listen Later Jan 13, 2024 106:12


TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Global dengue cases rise markedly (WHO) Measles outbreak in Philadelphia (Phil Health Dept) Viruses and organomineralization of travertine (Sci Rep) Neutralizing antibodies and clearance of HCV infection (Immunity) Letters read on TWiV 1079 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Global climate highlights 2023 and 7 new songs you should hear Brianne – Stuff you should know episodes: METI and SETI Kathy – Oppenheimer “Science, Mission, Legacy” documentaries from Los Alamos Lab One Two Three and Los Alamos National Laboratory Summer 2023 National Security Science: The Oppenheimer Issue Rich – The Wager: A Tale of Shipwreck, Mutiny and Murder by David Grann Alan – Less is Morse, an educational game Vincent – Citing Misinformation, Florida Health Official Calls for Halt to Covid Vaccines Listener Picks Sonrisa – Microorganisms in Perspective Anonymous – Wow! Human Cells Vibrate With Resonant Frequency and It's Technically Audible Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

This Week in Microbiology
301: Another Year is Microbial

This Week in Microbiology

Play Episode Listen Later Jan 3, 2024 47:18


A highly reduced TWiM team presents a study of the use of phage diversity in cell-free DNA to identify bacterial pathogens in human sepsis cases, and the evolution, persistence, and host adaptation of a gonococcal antimicrobial resistance plasmid that emerged in the pre-antibiotic era. Become a patron of TWiM. Links for this episode Phages identify sepsis pathogens (Nat Micro) Gonococcal AMR plasmid from pre-antibiotic era (PLoS Genetics) Take the TWiM Listener survey!

In 20xx Scifi and Futurism
In 2051 Virtual Gravity in Space

In 20xx Scifi and Futurism

Play Episode Listen Later Nov 19, 2023 40:09


Leia, a war-weary veteran, grapples with the challenges of adapting to civilian life in a future Atlanta where automation has reshaped society. As Leia navigates the complexities of her family dynamics and civilian routine, the narrative unfolds against the canvas of a society marked by political tensions and the ever-present influence of advanced technology, where even personal interactions are mediated by augmented reality.Leia's journey takes an unexpected turn when she learns of a unique job opportunity that beckons her to the vastness of space. As she contemplates this new chapter, political unrest on Earth adds a layer of suspense, culminating in a shocking twist that alters the course of Leia's life.Augmented Reality (AR) Glasses: Leia's civilian life is marked by the use of lightweight AR glasses, equipped with encrypted stream cameras for recording, and an Assistant AI that offers assistance and suggestions.Lutin Bots: Automated bots play a role in Leia's daily life, performing tasks like making omelets and biscuits. Premium skills, such as massage capabilities, can be added to these bots.Canal Link: A futuristic communication device that Leia uses, capable of providing an ads-free link, and undergoing regular updates for various features.Drone Blimps: Police employ drone blimps equipped with specialized AIs to locate potential threats, particularly mass shooters, during public demonstrations.Space Mining Company Opportunities: The narrative introduces the concept of space mining companies seeking technicians willing to live and work in space, reflecting advancements in extraterrestrial resource exploration.Superconductive Solar Arrays: The research and manufacturing space station in Earth's orbit features enormous superconductive solar arrays, harnessing near-zero gravity and temperature for advanced technological developments.3D-Printed Organs: In the narrative, organ transplants are 3D printed in space, using cells from the recipients, eliminating the need for immunosuppressants.Quantum Engines: A research group on the space station develops quantum engines for deep space travel, running in very low temperatures to power ships far from sunlight.Bio-Bots and Protein Transistors: Medical procedures involve bio-bots growing protein transistors next to nerves in the inner ear regions to mitigate space adaptation syndrome, providing a form of artificial gravity in virtual reality experiences.Phages for Disinfection: The space station employs phages for disinfection, replacing air with microbes that seek out and neutralize harmful agents, creating a forest-like environment.Voting via Canal Link: The story features a futuristic voting system where individuals receive encrypted ballots in their AR, allowing them to pre-vote using their Canal Links.Many of the characters in this project appear in future episodes. Using storytelling to place you in a time period, this series takes you, year by year, into the future. From 2040 to 2195. If you like emerging tech, eco-tech,futurism, perma-culture, apocalyptic survival scenarios, and disruptivescience, sit back and enjoy short stories that showcase my research into howthe future may play out.  This isEpisode 45 of the podcast "In 20xx Scifi and Futurism." The companionsite is https://in20xx.com where you can finda timeline of the future, descriptions of future development, and printedfiction.These areworks of fiction. Characters and groups are made-up and influenced by currentevents but not reporting facts about people or groups in the real world.Copyright© Leon Horn 2021. All rights reserved.

The Naked Scientists Podcast
Faeces and phages: Moulding the microbiome

The Naked Scientists Podcast

Play Episode Listen Later Nov 7, 2023 31:26


Today, we're helping you to get to know your microbiome, and hearing why a better understanding of it viewed by some as the next frontier in helping us to live longer, healthier lives. First, we explore the co-evolution of man and microbe, and the suite of modern techniques helping to clear up the remaining mysteries of the intestines. And, later on, how medicine is mobilsing the microbiome to ward of antibiotic resistant bacteria using faecal transplants and 'good' viruses... Like this podcast? Please help us by supporting the Naked Scientists

Incubation
Phages: Bacteria's Worst Nightmare

Incubation

Play Episode Listen Later Oct 26, 2023 30:13 Transcription Available


Can bacteriophages help us in the fight against antibiotic-resistant infections? Author Tom Ireland joins the show to discuss the fascinating world of bacteriophages, also known as phages – viruses that attack bacteria.. Then, Ben Chan, a researcher with a fridge full of phages, tells the story of what it was like putting them to use in a high-stakes case.See omnystudio.com/listener for privacy information.

This Week in Microbiology
295: Uncultured and Unmutable

This Week in Microbiology

Play Episode Listen Later Sep 22, 2023 66:48


TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target. Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin, Become a patron of TWiM. Links for this episode Phages avoid tRNA-targeting host defenses (eLife) Sea phages Actinobacteriophage database New antibiotic from uncultured bacterium (bioRxiv) The age of infection (For Policy) Killing bacteria by teixobactin (Nature) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

Maine Science Podcast
Alaina Weinheimer (ocean virology)

Maine Science Podcast

Play Episode Listen Later Aug 31, 2023 36:14


Alaina Weinheimer is a postdoctoral fellow at the Bigelow Laboratory for Ocean Sciences where she examines how bacteria fight viruses in the ocean. She is particularly interested in  jumbo phages, which are phages with really large genomes (> 200 kb). Until recently, they have been largely overlooked in both culture-based and sequencing studies due to their unusually large size that rivals bacteria! While pursuing her bachelor's degree in Biology at Penn State, Alaina worked in coral reef ecology labs where she was exposed to the numerous  threats to coral and the potential roles of microbes and viruses in  mediating or exacerbating these threats.  Alaina was a 5 Minute Genius™ speaker for the 2023 Maine Science Festival; you can watch her talk on our YouTube Channel: https://youtu.be/9GGe6kZfTHI?si=jcD4QnGj8GticN_JOur conversation was recorded in June 2023.~~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It was recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle.The Discover Maine theme was composed and performed by Nick Parker.To support the Maine Discovery Museum: https://www.mainediscoverymuseum.org/donate.  To support the Maine Science Festival, Maine's first and only science festival available free of charge to all, please visit our donation page.    Find us online:Maine Discovery MuseumMaine Science FestivalMaine Discovery Museum on social media: Facebook    InstagramMaine Science Festival on social media: Facebook    Twitter     InstagramMaine Science Podcast on social media: Facebook    Twitter     Instagram © 2023 Maine Discovery Museum 

This Week in Virology
TWiV 1039: Landmines for phages, a mouthful of redondoviruses

This Week in Virology

Play Episode Listen Later Aug 27, 2023 121:20


TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Anti-phage defense via capsid detection (Nature) Redondoviruses infect commensal amoebae (Cell Host Micro) A host for redondoviruses (Nat Rev Micro) Letters read on TWiV 1039 Timestamps by Jolene. Thanks! Weekly Picks Dickson – “Cosmic Time Machine” Netflix documentary Kathy – Antarctican accents Rich – Cymothoa exigua, or the tongue-eating louse, Week of wonder: The case for preserving parasites Jolene – Perspective article on best practices for improving graduate admissions Vincent – Why Chandrayaan-3 landed near the moon's south pole — and why everyone else wants to get there too Listener Picks Douglas – On Climate Change and (Active) Climate Management Matt – This Scientist Tracked Bats for Decades and Solved a Mystery About a Deadly Disease Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Lagrange Point
Episode 545 - Phages taking the fight to bacteria

Lagrange Point

Play Episode Listen Later Jul 31, 2023 10:57


Antibiotic resistance is a global challenge, but the solution may come from the natural predator of bacteria. Bacterial infections can be nasty, but you can engineer a phage to help better identify and treat them. Knowing exactly which bacteria is causing problems can help doctors target treatment more precisely and tailor antibiotic courses. Using bacteriophages  you can quickly identify and then eliminate common types of bacterial infections. Jiemin Du, Susanne Meile, Jasmin Baggenstos, Tobias Jäggi, Pietro Piffaretti, Laura Hunold, Cassandra I. Matter, Lorenz Leitner, Thomas M. Kessler, Martin J. Loessner, Samuel Kilcher, Matthew Dunne. Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-39612-0 Susanne Meile, Jiemin Du, Samuel Staubli, Sebastian Grossmann, Hendrik Koliwer-Brandl, Pietro Piffaretti, Lorenz Leitner, Cassandra I. Matter, Jasmin Baggenstos, Laura Hunold, Sonja Milek, Christian Guebeli, Marko Kozomara-Hocke, Vera Neumeier, Angela Botteon, Jochen Klumpp, Jonas Marschall, Shawna McCallin, Reinhard Zbinden, Thomas M. Kessler, Martin J. Loessner, Matthew Dunne, Samuel Kilcher. Engineered reporter phages for detection of Escherichia coli, Enterococcus, and Klebsiella in urine. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-39863-x

The Naked Scientists Podcast
Q&A: Love drugs and phaging superbugs

The Naked Scientists Podcast

Play Episode Listen Later Jul 11, 2023 60:59


It's a Question and Answer special this week. You supply the questions and we pose them to a panel of expert guests. Joining us this time, biologist and author Tom Ireland, marine scientist Liberty Denman, chemistry writer Philip Broadwith, and comedien Rosie Wilby. Like this podcast? Please help us by supporting the Naked Scientists

Mornings with Simi
Using phages to treat superbug infections

Mornings with Simi

Play Episode Listen Later Jul 5, 2023 9:18


IS Phage therapy going to be the next big thing in medicine?  How does it work and what types of illness can it help with? Guest: Dr. Greg German, an infectious disease physician at St. Joseph's Hospital, part of Unity Health in Toronto Learn more about your ad choices. Visit megaphone.fm/adchoices

Science Focus Podcast
The intriguing science of phages, with Tom Ireland

Science Focus Podcast

Play Episode Listen Later Jun 29, 2023 36:51


Even before the global COVID pandemic, simple mention of the word ‘virus' was likely to send shivers down most of our spines. But it turns out not all viruses are nasties. Ever heard of a phage? They are a type of virus that infect bacteria. Despite being one of the most common forms of life on Earth we still only know very little about them. However, current research suggests they may just be one of our greatest allies in the fight against superbugs. Learn more about your ad choices. Visit podcastchoices.com/adchoices

MICI Today
Microbiote

MICI Today

Play Episode Listen Later Jun 15, 2023 8:29


Qu'est-ce que le microbiote ? Quel est son historique ? Comment décrire le microbiote intestinal ? Quels sont les champs d'application du microbiote ? Comment décrire le microbiote au cours des MICI ? Quelles sont les voies de modulation du microbiote pour contrôler l'inflammation ? Quels sont les résultats de ces différentes voies ? Quel message transmettre aux auditeurs ? Le Pr Philippe Seksik, gastro-entérologue à l'hôpital Saint-Antoine à Paris, directeur d'une unité de recherche Inserm sur le Microbiote – Sorbonne Université, répond à vos questions.   Invité : Pr Philippe Seksik – Hôpital Saint-Antoine – Paris https://www.aphp.fr/service/service-35-073  https://www.crsa.fr/equipe-philippe-seksik.html  Le Pr Seksik déclare des liens d'intérêts avec les laboratoires Takeda, Merck MSD, Biocodex, Ferring, Janssen, Amgen, Pfizer, Pileje, Fresenius Kabi et Abbvie.   L'équipe :
 Comité éditorial : Pr Lucine Vuitton, Pr Guillaume Bouguen, Pr Mathurin Fumery, Dr Maeva Charkaoui, Dr Mathieu Uzzan, Justine Amaro, Charlotte Mailhat, Justine Pollet Animation :  Pyramidale Communication Production : Pyramidale Communication Soutien institutionnel : Pfizer   Crédits : Pyramidale Communication, Sonacom

Economist Podcasts
Babbage: How to battle superbugs with viruses

Economist Podcasts

Play Episode Listen Later May 17, 2023 46:56


Antimicrobial resistance killed over a million people in 2019. That figure is expected to rise to ten million by 2050. Antibiotics remain vital to modern medicine, but this hidden pandemic of drug-resistant superbugs is driving scientists to explore possible alternatives. One type of therapy in particular is attracting serious scientific interest: bacteriophages. Phages are viruses that can destroy bacteria. In the 1920s, phage therapies were used widely against infections, but much of the world abandoned the idea following the discovery of penicillin. Some parts of the former Soviet Union, though, have continued to use phage therapies. What can governments and international companies learn from this medicine?Gilead Amit, The Economist's science correspondent, travels to the Eliava Institute in Tbilisi, Georgia to find out how phage therapies have been used there over the last century. He speaks to the director, Mzia Kutateladze, head of phage production, Vakho Pavlenishvili, and from the therapy centre: Davit Sturia, Lia Nadareishvili and Lana Abesadze. Barry Rud, a Canadian patient attending the clinic, discusses his experience. Steffanie Strathdee, who leads phage research at the University of California, San Diego, explains the renewed international interest in bacteriophages. Alok Jha, The Economist's science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

Babbage from Economist Radio
Babbage: How to battle superbugs with viruses

Babbage from Economist Radio

Play Episode Listen Later May 17, 2023 46:56


Antimicrobial resistance killed over a million people in 2019. That figure is expected to rise to ten million by 2050. Antibiotics remain vital to modern medicine, but this hidden pandemic of drug-resistant superbugs is driving scientists to explore possible alternatives. One type of therapy in particular is attracting serious scientific interest: bacteriophages. Phages are viruses that can destroy bacteria. In the 1920s, phage therapies were used widely against infections, but much of the world abandoned the idea following the discovery of penicillin. Some parts of the former Soviet Union, though, have continued to use phage therapies. What can governments and international companies learn from this medicine?Gilead Amit, The Economist's science correspondent, travels to the Eliava Institute in Tbilisi, Georgia to find out how phage therapies have been used there over the last century. He speaks to the director, Mzia Kutateladze, head of phage production, Vakho Pavlenishvili, and from the therapy centre: Davit Sturia, Lia Nadareishvili and Lana Abesadze. Barry Rud, a Canadian patient attending the clinic, discusses his experience. Steffanie Strathdee, who leads phage research at the University of California, San Diego, explains the renewed international interest in bacteriophages. Alok Jha, The Economist's science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

Science Friday
Antibiotic Resistance, Space Launches and the Environment, Phage Therapy. May 5, 2023, Part 2

Science Friday

Play Episode Listen Later May 5, 2023 46:58


SpaceX Explosion Damages Environment Around Launch Site Last Thursday, SpaceX's South Texas facility was awash in noise and fire, as crowds gathered in South Padre Island and Port Isabel to watch Starship's first orbital launch. It was the largest and most powerful rocket ever made, standing at around 400 feet tall. Four minutes into the launch, SpaceX detonated the rocket after the SuperHeavy booster failed to separate from the Starship as planned. The launch destroyed the company's launch pad, spreading concrete up to three quarters of a mile away. Cameras left by YouTubers were either knocked down or destroyed in the rumble, along with some of the fence surrounding the launch pad's road-facing property. To read the rest, visit sciencefriday.com.   The Private Space Race Takes A Toll On Planet Earth After the SpaceX explosion last month, debris wasn't the only thing on the minds of Science Friday listeners. The following messages arrived in our inbox after we reported on 3-D printed rockets in March. It was interesting to hear you discuss 7 space launches in 5 days, and then just moments later the fact that we're not on track to reduce carbon emissions. My understanding is that rocket launches release huge amounts of carbon and other greenhouse gases. Story idea?—@RevBobIerien, Twitter Also regarding the 3-D rockets there wasn't any concern made for space pollution was there? I may have tuned out unhappily before the end. —Juanita H, email How much carbon do rockets contribute to global warming? —Robert C, email Very disappointing to hear the report of new “cheaper” 3D-printed rockets are available so that, like fast food pods and big gulps, we can now drop even more cheap **** into the ocean. And, *immediately* following a story about the new report on climate change, what exactly is the carbon footprint resulting from the ability of more people to more cheaply fire rockets into space? —David M, email Carbon isn't the big pollutant that comes from spaceflight, says Dr. Eloise Marais, associate professor in physical geography at University College London. Instead, black carbon or soot particles are generated and released directly into the atmosphere, alongside reactive nitrogen and nitrogen oxides. Dr. Marais joins Ira to talk about how much of an impact increased rocket launches could have on the atmosphere, and how that compares to the auto industry.    How To Combat The Antibiotic Resistance Crisis For years scientists have been ringing alarm bells about a global antibiotic resistance crisis. Now hospitals and healthcare facilities face the consequences: In the United States, there are 2.8 million antimicrobial-resistant infections every year, and more than 35,000 people die from these infections. Bacteria naturally try to outsmart the drugs designed to kill them, which causes treatments to become ineffective over time. While new antibiotics are made to respond to these resistant strains, the bacteria continue to evolve—creating a constant, and costly, cycle. There's a number of added factors driving the crisis, including antibiotic use in livestock and the general overprescription of antibiotics. About 1 in 3 antibiotic prescriptions in outpatient settings like urgent care or emergency departments are unnecessary. Scientists are struggling to keep up with the need to replace antibiotics that no longer work. It's a never ending game of catch up. Ira discusses some of the possible solutions to this vexing problem and takes listener questions with Dr. Victor Nizet, faculty lead of the Collaborative to Halt Antibiotic-Resistant Microbes at the University of California San Diego and Dr. Eddie Stenehjem, executive vice chair of medicine at the University of Colorado.   Are Phages A New Page In Medicine? One of the many possible solutions to the global antibiotic resistance crisis is an old idea that's new again—bacteriophages, or phages for short. Phages are viruses that exist solely to kill bacteria and are abundant in nature. While scientists first discovered phages' ability to treat bacterial infections about a century ago, there's been little interest in turning them into a treatment for patients with antibiotic resistant infections—until recently. Ira talks with Dr. Graham Hatfull, professor of biotechnology at the University of Pittsburgh about the latest in phage science.   Transcripts for each segment will be available the week after the show airs on sciencefriday.com.

ID:IOTS
47. ECCMID highlights part 3: Mythbusting, Sporotrichosis, phages, AMR, Paeds, Grand Round

ID:IOTS

Play Episode Listen Later Apr 28, 2023 33:00


Join Callum with guests Andrew Seaton, Marianna Avellar, Hannah Pymont, Eva Garmendia, Sanjay Patel and Dave Hettle live from ECCMID 2023. ECCMID sessions discussed:- Fairytales or reality, checking some eminence paradigms for treatment of severe infections- Neglected tropical skin diseases- Non-canonical approaches to treatment of infections- Paediatric interactive cases: dilemmas for the microbiologist and infection specialist- Clinical grand roundFor the AMR studio podcast: https://www.uac.uu.se/the-amr-studio/ BSAC paediatric pathways: https://bsac.org.uk/paediatricpathways/Music: https://pixabay.com/music/acoustic-group-outrigger-144123/Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or Tweet us @IDiots_podPrep notes for completed episodes can be found here: https://1drv.ms/u/s!AsaWoPQ9qJLShugmB2EOm8FMePNBtA?e=IKApb5If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Business Daily
Antibiotics: How to fix a broken market

Business Daily

Play Episode Listen Later Mar 20, 2023 18:23


Antibiotics stopped providing big gains for pharmaceutical companies decades ago, but as bacteria become more resistant to drugs, the world needs new classes of antibiotics to be discovered if we want to prevent the next global health crisis. Dr Tina Joshi, Associate Professor of Molecular Microbiology at the University of Plymouth explains that it's more likely antimicrobial resistance will kill large numbers of human beings before climate change does. Kasim Kutay, CEO of the investment fund Novo Holdings tells us that for big pharma companies, antibiotics are seen as a contribution to society rather than an investment that can provide a profit. How can firms be convinced to invest in an unprofitable product? We hear how Netflix might provide a good model and we explore research in Phages - a bacteria specialised in eating other bacteria. Phages are being championed by some as a potential substitute for antibiotics. One patient in Minnesota tells us Phages saved his life. Presenter / producer: Stefania Gozzer Image: Dr Tina Joshi; Credit: Dr Tina Joshi

The Scope of Things
Episode: 11 - Dr. Graham Hatfull on the Benefits of Phage Therapy and the Future of Phage Clinical Trials

The Scope of Things

Play Episode Listen Later Feb 7, 2023 32:11


Healthcare professionals are searching for new ways to fight bacterial infections as growing concerns around antibiotic resistance reach new heights. Though bacteriophages or phages—viruses that infect only bacteria—have long since captured scientists' attention, they are quickly gaining popularity as a new and promising therapeutic tool. In this episode, Graham Hatfull, professor of biological sciences at the University of Pittsburgh, speaks with host Deborah Borfitz about his team's research and diligent work to showcase phages as versatile therapeutic agents. Hatfull also talks about the impressive findings produced by experimental phage therapy clinical trials and the barriers that currently prevent phages from ubiquitous antibacterial clinical use. He discusses his team's efforts to sequence phages and build a therapeutic library, the role of phage therapy in combating tuberculosis and cystic fibrosis, and the novel benefits phages bring to transplant recipients. Hatfull also addresses the FDA's support of phage therapy through expanded access for compassionate use and the global push to enter phages into their first-ever randomized controlled trial.  Links from this episode:  Clinical Research NewzUniversity of Pittsburgh Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease SEA-PHAGES (Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science) FDA Expanded Access for Compassionate Use Phage Australia 

ohmTown
Supremely Bribed while Phages create Vaccines, and more news.

ohmTown

Play Episode Listen Later Nov 29, 2022 36:19


Welcome to The ohmTown Daily News Show (ODNS). The show is held live on https://www.twitch.tv/ohmTown/ at 6PM Eastern. I cover a selection of aggregated news articles and discuss them briefly with a perspective merging business, technology, and society.Episode: ohmTown Daily News Show for November 29th, 2022. (Episode 333)Articles Discussed:what-the-brightest-young-minds-in-real-estate-are-working-onmusicians-arent-losing-out-from-streaming-musicrussian-vodka-trademark-auction-gets-green-lightnetflix-top-10-wednesday-snaps-stranger-things-4-recordpoverty-linked-to-facebook-and-instagram-addictionthousands-of-phages-found-to-have-crispr-gene-editing-systempoverty-linked-to-facebook-and-instagram-addiction-in-teensenerza-is-developing-a-robot-named-boagta-was-a-game-about-playing-an-angry-dinosaursupreme-court-concerned

Heal Nourish Grow Podcast
Improving the Skin Microbiome to Combat Acne

Heal Nourish Grow Podcast

Play Episode Listen Later Sep 7, 2022 42:42


In this week's episode I spoke with Dr. Yug Varna, co-founder and CEO of Phyla. Together with his co-founder, they created the world's most advanced probiotic acne system. The other co-founder, Maria Cho, struggled to find an effective solution to treat her acne. Yug and Maria worked together to create a product that addressed her skin condition in a way other skincare doesn't. Using what they knew about the skin's microbiome, Dr. Varma and Dr. Cho developed Phylabioitics. Skin's Microbiome To prove the efficacy of the new product, they ran clinical trials on phages and how they affect microbiome diversity. Phages are part of the skin microbiome and are helpful in combating acne since they kill harmful bacteria. Dr. Varna has a Ph.D. in microbiology from Johns Hopkins University and conducted over 10 years of microbiome research at UCSF. His passion was looking for the technology to support his products.  He discusses the differences between the microbiome in our gut vs the skin's microbiome. The skin microbiome refers to the ecosystem of microbes on your skin, comparing it a rainforest. It helps protect you from pathogens that could affect your system and overall health.  Watch the episode on YouTube

THE EXPLODING HUMAN with Bob Nickman
YUG VARMA: THE MICROBIOME, A CURE FOR ACNE & MORE: EP. 139

THE EXPLODING HUMAN with Bob Nickman

Play Episode Listen Later Sep 4, 2022 50:04


YUG VARMA, PhD, is the cofounder and CEO of Phyla, the world's most advanced probiotic acne system. he has 10+ years of of microbione reseach experience including an extensive background in bio-organic chemistry, microbiology and synthetic biology. We talk about what the microbiome is, how it functions in the body and the use of 'Phages" to target the specific bacteria which cause acne. Dr. Varma's mission is to change the way we treat chronic bacterial diseased, and is working tirelessly to achieve his goal. He is clearly one of those individuals at the forefront of this relatively new field of microbiome research and solutions.   He has generously offered a discount on Phyla products, using the code explode when purchasing at www.phylabiotics.com

The Science Hour
First images from the James Webb Space Telescope

The Science Hour

Play Episode Listen Later Jul 16, 2022 63:10


Roland Pease talks to two astronomers who began working on the James Webb Space Telescope more than two decades ago and have now seen the first spectacular results of their labours. Marcia Rieke of the University of Arizona and JWST's senior project scientist John Mather discuss the highlights of the first four images. Also in the programme, geologists discover precisely where on the Red Planet the most ancient Martian meteorite came from - we speak to Anthony Lagain whose detective work identified the crater from which the rock was ejected into space. And what causes vast areas of the Indian Ocean to glow with strange light - a rare and mysterious phenomenon known as 'milky seas'? The world is a step closer to understanding this centuries' old maritime enigma thanks to the crew of a yacht sailing south of Java, atmospheric scientist Steven Miller and marine microbiologist Kenneth Nealson. We are running out of ammunition against certain infections, as bacteria increasingly evade the antibiotics we've relied on for nearly a century. Could bacteriophages – viruses that hunt and kill bacteria – be part of the solution? In 2019, CrowdScience travelled to Georgia where bacteriophages, also known as phages, have been used for nearly a hundred years to treat illnesses ranging from a sore throat to cholera. Here we met the scientists who have kept rare phages safe for decades, and are constantly on the look-out for new ones. Phages are fussy eaters: a specific phage will happily chew on one bacteria but ignore another, so hunting down the right one for each infection is vital. Since then, we've lived through a pandemic, the medical landscape has been transformed, and interest in bacteriophages as a treatment option is growing throughout the world. We turn to microbiologist Professor Martha Clokie for updates, including the answer to listener Garry's question: could phages help in the fight against Covid-19?

CrowdScience
Are viruses the key to fighting infections?

CrowdScience

Play Episode Listen Later Jul 15, 2022 32:28


We are running out of ammunition against certain infections, as bacteria increasingly evade the antibiotics we've relied on for nearly a century. Could bacteriophages – viruses that hunt and kill bacteria – be part of the solution? In 2019, CrowdScience travelled to Georgia where bacteriophages, also known as phages, have been used for nearly a hundred years to treat illnesses ranging from a sore throat to cholera. Here we met the scientists who have kept rare phages safe for decades, and are constantly on the look-out for new ones. Phages are fussy eaters: a specific phage will happily chew on one bacteria but ignore another, so hunting down the right one for each infection is vital. Since then, we've lived through a pandemic, the medical landscape has been transformed, and interest in bacteriophages as a treatment option is growing throughout the world. We turn to microbiologist Professor Martha Clokie for updates, including the answer to listener Garry's question: could phages help in the fight against Covid-19? Contributors: Prof Martha Clokie, University of Leicester Dr Naomi Hoyle, Eliava Phage Therapy Center Prof Nina Chanishvili, Eliava Institute Dr Eka Jaiani, Eliava Institute Presented by Marnie Chesterton Produced by Cathy Edwards and Louisa Field for the BBC World Service [Photo:Bacteriophages infecting bacteria, illustration. Credit: Getty Images]

The Current Cucurbit Podcast

Dr. Gwyn Beattie, a faculty member at ISU's PLPM Department, walks us through the science behind working with bacteriophages (or phages for short) as potential biocontrol agents and their implications for IPM.

Curieux comme Rémy
Curieux comme Rémy - Les Phages

Curieux comme Rémy

Play Episode Listen Later Mar 18, 2022


Avec Rémy André

Microbe Magazine Podcast
Phages as Therapeutic Tools Against Multidrug Resistant Bacteria (AAC ed.)

Microbe Magazine Podcast

Play Episode Listen Later Mar 5, 2022 43:32


Bacteriophages are interesting viruses that target bacteria and have been used for therapeutic purposes. Recently, the emergence of antibiotic resistance has spurred a renewed interest in using these viruses or their products as therapeutic tools against recalcitrant human pathogens. AAC has also published a recent manuscript from ARLG to guide the use of phages in clinical practice. We will discuss with experts in the field the state-of-the-art in phage therapy. Objectives: • Understand the use of bacteriophages and their products for therapeutic purposes • Discuss the clinical applications of phages • Debate the barriers for developing of phages as therapeutic tools to treat multidrug-resistant infections Guests: • Vincent A. Fischetti, Ph.D, Professor and Director, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY. • Saima Aslam, MBBS, Professor of Medicine, University of California San Diego, San Diego, CA. • Anthony Maresso, PhD. Professor and Founder of TAILOR Labs, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX. This episode of Editors in Conversation is brought to you by the Antimicrobial Agents and Chemotherapy Journal and hosted by AAC Editor in Chief, Cesar Arias. AAC is available at https://asm.org/aac. Follow Cesar on twitter at https://twitter.com/SuperBugDoc for AAC updates. Subscribe to the podcast at https://asm.org/eic

Optimal Performance Podcast
362 Cure acne and maskne with Yug Varma from Phyla

Optimal Performance Podcast

Play Episode Listen Later Feb 18, 2022 40:37


Scientists now specifically what causes acne and how to cure it.  One specific bacteria called Cutibacterium acnes causes acne.  By targeting the bad bacteria and keeping and feeding the good bacteria on your face, your acne acne, redness and inflammation goes away.  Learn more here: phylabiotics.com Find Optimal Performance Podcast episodes, discounts on health optimization gear and learn about the work I do as a Life Coach and Performance Coach at Seanmccormick.com  In this episode we cover:    •Where does acne come from specifically? •Phages are your friends to keep skin healthy and vibrant •Clinical trials show specifically how acne can be treated.  •Harmful acne treatments like Acutane can cause depression and damage skin long-term •Controlling the growth of Cutibacteria acnes bacteria is how you eliminate acne •How stress, hormones, diet and genetics can increase the appearance of that acne causing bacteria      

Phage Therapy Today
Phage Exploration and Phage Therapy @BCM TailorLabs with Dr. Sabrina Green: Phages, from Bench to Bedside

Phage Therapy Today

Play Episode Listen Later Nov 23, 2021 44:41


We may think the magic in phage therapy is in the treatment. That is true. But to make this magic happen, collaborative team efforts is necessary to  together prepare the stage and get ready for the show. Dr. Sabrina Green is currently the director of R&D at Baylor college of medicine Tailorlabs 'https://www.bcm.edu/research/research-centers/tailor'. On this episode, we sit down and truly understand the steps required to develop a phage product and supply it to the patients. Happy Listening!

Mayo Clinic Talks
Genes and Your Health Series: Hot Topics in Phage Therapy

Mayo Clinic Talks

Play Episode Listen Later Nov 18, 2021 27:20


To claim credit for this episode, visit: Mayo Clinic Talks Podcast: Genes & Your Health Guests: Gina A. Suh, M.D. Host: Denise M. Dupras, M.D., Ph.D. What is Phage Therapy? When was it discovered? Where is it used? We know about antibiotics, antifungals, and antivirals, but this is a whole new world! Have no fear, this episode is here from the Genes & Your Health miniseries to help demystify all there is to know about Phages. Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.  

The Boma
Phages - Bad for bacteria, good for livestock farmers

The Boma

Play Episode Play 39 sec Highlight Listen Later Nov 15, 2021 18:52 Transcription Available


Livestock farmers use antibiotics to treat infections in their animals, and may also use them as a preventative. But overuse of antibiotics can create 'superbugs' - antimicrobial-resistant (AMR) bacteria which threaten human lives and wellbeing, as well as those of livestock animals.Presenters Brenda Coromina and Elliot Carleton explore one approach that ILRI scientists are taking to combat the AMR problem - phages. These 'bacteria-eating' viruses, which naturally exist in the environment, are being studied by ILRI scientists to develop an alternative treatment to antibiotics. They hear from 'phage hunters' Angela Makumi and Nicholas Svitek about how phages work, what makes them different from antibiotics, and what it will take to make phage therapy a reality.Could phages become our future weapon of choice against bacteria?Read more: Phages: The viruses that offer a sustainable alternative to antibiotic treatment in livestock

The Bioinformatics and Beyond Podcast
Dr. Sabrina Green: Clinical Use of Phages

The Bioinformatics and Beyond Podcast

Play Episode Listen Later Mar 27, 2021 29:08


In this episode, Dr. Sabrina Green discusses the clinical aspects of phage use. We start by going back to one of the first ever uses of phage for a bacterial infection before discussing how phages are used now. Dr. Green explains a wide range of details related to clinical phage use. Topics discussed include cases today where phages are used, the safety of phages for clinical use, regulatory considerations for phage therapies, the pros and cons of phages, how specific phages are matched to specific patients, and phage affordability. Dr. Green describes potential hurdles for widespread adoption such as convincing people that viruses can be good for you. For further reading see https://www.liebertpub.com/doi/10.1089/phage.2020.0007 and https://mbio.asm.org/content/12/1/e03474-20

The Bioinformatics and Beyond Podcast
Dr. Sabrina Green: Phages and Phage Discovery

The Bioinformatics and Beyond Podcast

Play Episode Listen Later Mar 20, 2021 26:20


Dr. Sabrina Green introduces the concepts of phages and phage therapy. She describes what phages are and gives us a bit of history on phage therapy, describing reasons why antibiotics were widely adopted despite phages being discovered first. She also discusses why phages have become so important in the light of emerging antibiotic resistant pathogens. Dr. Green explains the mechanisms of how phages work and how these mechanisms lend themselves well to, for instance, scaling to different types of infections and getting cleared from a person's system. Finally, we discuss how phages are discovered, such as through evolving phages and engineering phages. We learn about a specific paper Dr. Green authored involving finding novel phages from bird droppings. Finally, we discuss potential areas for bioinformatics contributions in the field of phages. Papers referenced include https://www.liebertpub.com/doi/10.1089/phage.2020.0007 and https://mbio.asm.org/content/12/1/e03474-20

Texas Lyme Alliance with Kristina Bauer
Biologix phage therapy for Lyme with Dr. Marty Hart and Kristina Bauer

Texas Lyme Alliance with Kristina Bauer

Play Episode Listen Later Oct 6, 2020 70:53


This interview explains Biologix proprietary phage therapy that is showing success clearing Persistent Lyme Disease, or PLD and coinfections in a gentle way, even for the most sensitive of patients 45 days after treatment.  Kristina discusses with Dr. Hart what a potential patient might expect from treatment at Biologix and why phage therapy.  It does not treat known illnesses, rather supports the body in being able to do the work by providing the phages specific to each strain a patient presents.Phage is a holistic treatment that has the potential of supporting the body to clear a multitude of pathogens such as Lyme, cancer, COVID, viruses, parasites, and persisters.  A clinical study is underway to show the results of 30 patients.  It will be shared on Facebook @ Texas Lyme Alliance, Twitter @TexasLyme on online at www.TexasLymeAlliance.org.Did you know that your immune system should not be made solely responsible for killing the infections in your body? Phages—or viruses that do not infect human cells—are well-known entities whose sole purpose is to swarm host microbes and replicate themselves in order to attack and kill them. Using Induced Native Phage Therapy, we at the Biologix Center have discovered exactly how to access the bacteriophages (phages that attack bacteria), mycophages (phages that attack mold and fungi), and virophages (phages that attack other viruses) that already reside inside your body and induce them to eliminate, in most cases, all infectious microbes wreaking havoc there.**This is not medical advice.  Kristina Bauer has no conflicts of interest and is not paid for services.  Texas Lyme Alliance supports this work and also does not receive payment for services from Biologix or any of its entities.  Kristina or Texas Lyme Alliance's effort is to support patients through the sharing of information and education and does not recommend any treatment.  We want patients to heal, stay out of bed, and get back to life at work and in their families.For more information, contact the Biologix Center at www.BiologixCenter.com.  Subscribe for future educational videos on healing Lyme Disease by clicking the subscribe button and sharing this video.  Thanks for watching and good luck!Support the show