Podcasts about phages

 Finally, there is a remedy, even invented 100 years ago…Called Phages bacterial treatmentWhat is Phage Therapy?Phages, formally known as bacteriophages, are viruses that solely kill and selectively target bacteria. They are the most common biological entities in nature and have been shown to effectively fight and destroy multi-drug resistant bacteria. Namely, when all antibiotics fail, phages still succeed in killing the bacteria and may save a life from an infection.The phage virus needs a host where it can spread its eggs. The host is that specific bacteria that you want to kill. The phage virus injects its eggs inside that bacteria. The eggs grow to that phage virus and kill the bacteria… Thousands of new phage viruses search for the correct bacteria …  Imagine that… After a short time, all the bacteria are killed. The problem is to find the correct phage virus to kill that specific bacteria or even the Superbug. And that can be done because you find the phage virus everywhere… At least in garbage places or water filtering systems.  The main concern for all of us now is the alarming rate of increasing 'superbugs' that are resistant to most — if not all — antibiotics, as well as the impact they will have on human health and the longevity of life. These issues, combined with a lack of regulation to approve the process of phage therapy for anything less than an absolute, no-alternative emergency, pose a serious concern for us. We hope that through our work here at PATH, we can make this treatment more widely available to save lives where no other treatments could.My Video: How to kill dangerous bacteria like the Superbugs? https://youtu.be/H_BSLJ8bzfQMy Audio: https://divinesuccess.net/wp-content/uploads/2021/Podcast4/How-to-kill-dangerous-bacteria-like-the-Superbugs.mp3

Parkinson's and gut health: The connection you need to understand! Uncover practical steps you can take today to support a healthier gut environment and improve overall well-being for both patient and caregiverIn this episode of The One Thing Podcast, Dr. Adam Rinde dives deep into the fascinating world of the microbiome with Martha Carlin, a citizen scientist, entrepreneur, and microbiome expert. After her husband's Parkinson's diagnosis, Martha took a radical approach—teaching herself chemistry, microbiology, and systems biology to uncover the connection between gut health and neurological conditions. Martha is the founder of **The Biocollective** and **BiotiQuest**  @biotiquest4511  , and her research has led to groundbreaking discoveries in gut health, probiotics, and disease prevention. In this episode, she shares insights on how the microbiome impacts brain health, digestion, and overall well-being, including how gut bacteria might be a key player in Parkinson's disease.

In this episode, Celina Tanbari from the University of Ottawa interviews Dr. Adam Rudner about the fascinating world of bacteriophages—viruses that target and kill bacteria. Dr. Rudner is the coordinator of the University of Ottawa's Phage Hunters program, a member of the SEA-PHAGES and SEA-GENES programs, and an Associate Professor in the Department of Biochemistry, Microbiology, and Immunology. Dr. Rudner shares with us his expert opinion on a study that isolated bacteriophages from human skin to kill infection-causing bacteria. The discussion delves into the therapeutic potential of phages, their involvement in biofilms and lysogeny, and the challenges associated with utilizing phages in medicine. This episode was produced and written by Emma Etchells Foisy, hosted by Celina Tanbari, and audio edited by Sam Rogers. Copyrights are reserved to BEaTS Research Radio and the University of Ottawa.If you are interested in learning more about the paper we discussed today, you can find it through the following link: https://pmc.ncbi.nlm.nih.gov/articles/PMC10117716/Learn more: https://www.uottawa.ca/faculty-medicine/dr-adam-rudner 0:03 | BEaTS and host introduction.0:38 | Introducing Dr. Rudner.1:05 | What are bacteriophages?1:41 | Phages as a possible solution to antibiotic-resistant bacteria 2:41 | What are biofilms, and how do they affect bacterial infections?5:01 | Phage BE01 and how lysogeny can affect phage therapy.8:52 | Phage BE04 and the potential of phages in replacing antibiotics. 10:55 | Squashing the stigma, phages only attack bacteria.12:35 | Potential challenges with phage therapy. 14:08 | Dr. Rudner's take-home message. 14:36 | Thank yous and credits!Soundtrack, Chillout by AudioCoffee | https://www.audiocoffee.net/Music promoted by https://www.chosic.com/free-music/all/Creative Commons CC BY-SA 3.0https://creativecommons.org/licenses/by-sa/3.0/

It sounds like something from an advertisement for bathroom cleaner: Researchers found over 600 different viruses, most of which are new to science, in samples taken from showerheads and toothbrushes. The viruses, however, are unlikely to affect humans. They are bacteriophages, a type of virus that preys on bacteria. The expedition into bathroom biodiversity was recently published in the journal Frontiers in Microbiomes.Around a hundred years ago in the former Soviet Union, there were major efforts to develop bacteriophages for medical use. The approach really didn't catch on in Western countries, overshadowed there by the rise of conventional antibiotics like penicillin. But with some diseases developing resistance to those conventional antibiotics, there's been increased interest in phages as part of an antibacterial toolkit.Dr. Erica Hartmann, an associate professor in the department of Civil & Environmental Engineering at Northwestern University, joins Ira to talk about what researchers found when they took a close look at a collection of bathroom samples, and how phage research has advanced in recent years.Transcript for this segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Today's story is a good example of how little we know about biology and life, and how we can use our knowledge to better fight diseases and environmental threats. We are going to talk about bacteriophages or just fages. These are small viruses which attack bacteria. The story is literally about life and death and most organisms on earth are being killed every week. Senior researcher Namiko Mitarai from the biocomplexity group at the Niels Bohr Institute in Copenhagen Namiko Mitarai is being interviewe by Science Journalist Jens Degett.

With all the hubbub around phage therapy, why hasn't this replaced antibiotics entirely? We'll touch on some of the reasons in today's episode..Music by Muzaproduction from Pixabayhttps://www.instagram.com/sciencewithdr_k/ https://www.youtube.com/channel/UC2EttB4pjdZ4WrU3-z4RqPghttps://www.nature.com/articles/s41564-024-01705-xhttps://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00612-5/abstracthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278648/https://www.nature.com/articles/s41591-021-01403-9 https://www.nature.com/articles/d41586-023-02209-0

TWiM explains a new mechanism for preventing lysogeny through temperate phage-antibiotic synergy, and Salmonella expansion in the murine gut dependency on aspartate derived from reactive oxygen species-mediated microbiota lysis. Hosts: Michael Schmidt, Petra Levin and Michele Swanson. Become a patron of TWiM. Links for this episode Temperate phage-antibiotic synergy (mBio) Salmonella expansion dependent on aspartate (Cell Host Micr) Arrowsmith by Sinclair Lewis (Wiki) A Genetic Switch by Mark Ptashne Lysis timing and bacteriophage fitness (Genetics) HK97 capsid assembly (Ad Exp Med Biol) Mode of action of fluoroquinolones (Drugs) Salmonella a foodborne pathogen (CDC) Freeman Hrabowski Scholars Program (HHMI) Sam Kaplan - 30 years of Microbiology (McGovern Medical School) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

In this Part 2 of the Alloutcoach podcast episode focused on phage therapy to fight infections and antimicrobial resistance, I spoke to the Chief Physician at the globally leading center of excellence of an alternative, effective treatment approach to antibiotics, Dr. Dea Nizharadze at the Eliava Phage Therapy Center (EPTC) based in Tbilisi, Georgia. She explains the basic principles of phage treatments, its unique qualities, advantages and real-world clinical examples of methods and types of patients and infections this personalized therapy specifically targets. 0:00 Episode Introduction 1:42 Why the Republic of Georgia is a global leader in phage therapy 2:39 How phage therapy works in bacterial infections?Eliava Phage Therapy Center (EPTC) was founded in 1923 by Professor George Eliava who had collaborated with Felix D'Herelle, who had discovered phages, and while most other countries turned to antibiotics only, it is the only institution in the world that has continued to research bacteriophages without a pause of even one day since its inception and therefore collected the greatest research and real-world clinical experience with phages. 5:34 How do phages work to eradicate or stop further growth of bacteria? Phages are biological "weapons" against bacteria, namely viruses that target specific microbes only, without destroying the "good" bacteria or microbiota. They are naturally occurring substances and have no safety concerns. In some patients with antimicrobial resistance phage therapy enables improvement in sensitivity. 10:42 Synergistic effect of phage combination therapy with antibiotics 11:58 Phage Therapy Doisng and Success Factors 15:14 Length of phage treatmentIn chronic infections phage therapy may divided into 3 stages and last 15-20 days, and varies by nature and severity of disease. Patient treatment includes days off therapy, or holidays, however, bacterial analysis is continued and patient condition is monitored throughout the entire course of treatment. Success of therapy is indicated when bacterial titers and virulence decrease or bacteria are eradicated. Patient's objective and subjective signs and symptoms often vary throughout response to therapy. 16:42 Phage Product Variability and Market Availability How do we ensure educating patients to access the correct, most appropriate therapy for their infections 17:35 Multi-disciplinary personalized team care and telemedicine 19:53 Steps for patients outside of Georgia to access phage therapy via telemedicine? 24:04 Affordability and access to phage treatments 25:23 How to contact Eliava Phage Therapy Center

Phages, microbes, and scientific conundrums, oh my! Shaun Duke turns the tables on Daniel Haeusser to ask a metric ton of questions about microbiology. Why? Because Daniel is one of those legit scientists. Join us for a wide ranging and utterly wild conversation about bacteria, viruses, micro-whatsits, and speculative wonders! Thanks for listening. We hope […]

Laura Kahn is a leader in the field of "One Health," which studies the interdependence of human, veterinary, and environmental health issues. She authored a book about the increasing resistance of microbes to antibiotics and antiviral medications, mainly because of over-exposure. For the video, audio podcast, transcript, and comments: https://tosavetheworld.ca/episode-604-anti-microbial-resistance.

Antibiotics may become useless in our lifetime. Doctors are looking to the past for help

Drug-resistant bacteria has long been a problem for doctors in hospitals around the world. Today, a case study by University of Pittsburgh School of Medicine scientists was published in the American Society for Microbiology journal mBio. The senior author on the paper is Dr. Daria Van Tyne. She explained to Rick Dayton how they found success with Phages in combination with antibiotics. 

TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Global dengue cases rise markedly (WHO) Measles outbreak in Philadelphia (Phil Health Dept) Viruses and organomineralization of travertine (Sci Rep) Neutralizing antibodies and clearance of HCV infection (Immunity) Letters read on TWiV 1079 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Global climate highlights 2023 and 7 new songs you should hear Brianne – Stuff you should know episodes: METI and SETI Kathy – Oppenheimer “Science, Mission, Legacy” documentaries from Los Alamos Lab One Two Three and Los Alamos National Laboratory Summer 2023 National Security Science: The Oppenheimer Issue Rich – The Wager: A Tale of Shipwreck, Mutiny and Murder by David Grann Alan – Less is Morse, an educational game Vincent – Citing Misinformation, Florida Health Official Calls for Halt to Covid Vaccines Listener Picks Sonrisa – Microorganisms in Perspective Anonymous – Wow! Human Cells Vibrate With Resonant Frequency and It's Technically Audible Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

A highly reduced TWiM team presents a study of the use of phage diversity in cell-free DNA to identify bacterial pathogens in human sepsis cases, and the evolution, persistence, and host adaptation of a gonococcal antimicrobial resistance plasmid that emerged in the pre-antibiotic era. Become a patron of TWiM. Links for this episode Phages identify sepsis pathogens (Nat Micro) Gonococcal AMR plasmid from pre-antibiotic era (PLoS Genetics) Take the TWiM Listener survey!

Leia, a war-weary veteran, grapples with the challenges of adapting to civilian life in a future Atlanta where automation has reshaped society. As Leia navigates the complexities of her family dynamics and civilian routine, the narrative unfolds against the canvas of a society marked by political tensions and the ever-present influence of advanced technology, where even personal interactions are mediated by augmented reality.Leia's journey takes an unexpected turn when she learns of a unique job opportunity that beckons her to the vastness of space. As she contemplates this new chapter, political unrest on Earth adds a layer of suspense, culminating in a shocking twist that alters the course of Leia's life.Augmented Reality (AR) Glasses: Leia's civilian life is marked by the use of lightweight AR glasses, equipped with encrypted stream cameras for recording, and an Assistant AI that offers assistance and suggestions.Lutin Bots: Automated bots play a role in Leia's daily life, performing tasks like making omelets and biscuits. Premium skills, such as massage capabilities, can be added to these bots.Canal Link: A futuristic communication device that Leia uses, capable of providing an ads-free link, and undergoing regular updates for various features.Drone Blimps: Police employ drone blimps equipped with specialized AIs to locate potential threats, particularly mass shooters, during public demonstrations.Space Mining Company Opportunities: The narrative introduces the concept of space mining companies seeking technicians willing to live and work in space, reflecting advancements in extraterrestrial resource exploration.Superconductive Solar Arrays: The research and manufacturing space station in Earth's orbit features enormous superconductive solar arrays, harnessing near-zero gravity and temperature for advanced technological developments.3D-Printed Organs: In the narrative, organ transplants are 3D printed in space, using cells from the recipients, eliminating the need for immunosuppressants.Quantum Engines: A research group on the space station develops quantum engines for deep space travel, running in very low temperatures to power ships far from sunlight.Bio-Bots and Protein Transistors: Medical procedures involve bio-bots growing protein transistors next to nerves in the inner ear regions to mitigate space adaptation syndrome, providing a form of artificial gravity in virtual reality experiences.Phages for Disinfection: The space station employs phages for disinfection, replacing air with microbes that seek out and neutralize harmful agents, creating a forest-like environment.Voting via Canal Link: The story features a futuristic voting system where individuals receive encrypted ballots in their AR, allowing them to pre-vote using their Canal Links.Many of the characters in this project appear in future episodes. Using storytelling to place you in a time period, this series takes you, year by year, into the future. From 2040 to 2195. If you like emerging tech, eco-tech,futurism, perma-culture, apocalyptic survival scenarios, and disruptivescience, sit back and enjoy short stories that showcase my research into howthe future may play out.  This isEpisode 45 of the podcast "In 20xx Scifi and Futurism." The companionsite is https://in20xx.com where you can finda timeline of the future, descriptions of future development, and printedfiction.These areworks of fiction. Characters and groups are made-up and influenced by currentevents but not reporting facts about people or groups in the real world.Copyright© Leon Horn 2021. All rights reserved.

Today, we're helping you to get to know your microbiome, and hearing why a better understanding of it viewed by some as the next frontier in helping us to live longer, healthier lives. First, we explore the co-evolution of man and microbe, and the suite of modern techniques helping to clear up the remaining mysteries of the intestines. And, later on, how medicine is mobilsing the microbiome to ward of antibiotic resistant bacteria using faecal transplants and 'good' viruses... Like this podcast? Please help us by supporting the Naked Scientists

Can bacteriophages help us in the fight against antibiotic-resistant infections? Author Tom Ireland joins the show to discuss the fascinating world of bacteriophages, also known as phages – viruses that attack bacteria.. Then, Ben Chan, a researcher with a fridge full of phages, tells the story of what it was like putting them to use in a high-stakes case.See omnystudio.com/listener for privacy information.

TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target. Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin, Become a patron of TWiM. Links for this episode Phages avoid tRNA-targeting host defenses (eLife) Sea phages Actinobacteriophage database New antibiotic from uncultured bacterium (bioRxiv) The age of infection (For Policy) Killing bacteria by teixobactin (Nature) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

Alaina Weinheimer is a postdoctoral fellow at the Bigelow Laboratory for Ocean Sciences where she examines how bacteria fight viruses in the ocean. She is particularly interested in  jumbo phages, which are phages with really large genomes (> 200 kb). Until recently, they have been largely overlooked in both culture-based and sequencing studies due to their unusually large size that rivals bacteria! While pursuing her bachelor's degree in Biology at Penn State, Alaina worked in coral reef ecology labs where she was exposed to the numerous  threats to coral and the potential roles of microbes and viruses in  mediating or exacerbating these threats.  Alaina was a 5 Minute Genius™ speaker for the 2023 Maine Science Festival; you can watch her talk on our YouTube Channel: https://youtu.be/9GGe6kZfTHI?si=jcD4QnGj8GticN_JOur conversation was recorded in June 2023.~~~~~~The Maine Science Podcast is a production of the Maine Discovery Museum. It was recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle.The Discover Maine theme was composed and performed by Nick Parker.To support the Maine Discovery Museum: https://www.mainediscoverymuseum.org/donate.  To support the Maine Science Festival, Maine's first and only science festival available free of charge to all, please visit our donation page.    Find us online:Maine Discovery MuseumMaine Science FestivalMaine Discovery Museum on social media: Facebook    InstagramMaine Science Festival on social media: Facebook    Twitter     InstagramMaine Science Podcast on social media: Facebook    Twitter     Instagram © 2023 Maine Discovery Museum 

TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Anti-phage defense via capsid detection (Nature) Redondoviruses infect commensal amoebae (Cell Host Micro) A host for redondoviruses (Nat Rev Micro) Letters read on TWiV 1039 Timestamps by Jolene. Thanks! Weekly Picks Dickson – “Cosmic Time Machine” Netflix documentary Kathy – Antarctican accents Rich – Cymothoa exigua, or the tongue-eating louse, Week of wonder: The case for preserving parasites Jolene – Perspective article on best practices for improving graduate admissions Vincent – Why Chandrayaan-3 landed near the moon's south pole — and why everyone else wants to get there too Listener Picks Douglas – On Climate Change and (Active) Climate Management Matt – This Scientist Tracked Bats for Decades and Solved a Mystery About a Deadly Disease Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Antibiotic resistance is a global challenge, but the solution may come from the natural predator of bacteria. Bacterial infections can be nasty, but you can engineer a phage to help better identify and treat them. Knowing exactly which bacteria is causing problems can help doctors target treatment more precisely and tailor antibiotic courses. Using bacteriophages  you can quickly identify and then eliminate common types of bacterial infections. Jiemin Du, Susanne Meile, Jasmin Baggenstos, Tobias Jäggi, Pietro Piffaretti, Laura Hunold, Cassandra I. Matter, Lorenz Leitner, Thomas M. Kessler, Martin J. Loessner, Samuel Kilcher, Matthew Dunne. Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-39612-0 Susanne Meile, Jiemin Du, Samuel Staubli, Sebastian Grossmann, Hendrik Koliwer-Brandl, Pietro Piffaretti, Lorenz Leitner, Cassandra I. Matter, Jasmin Baggenstos, Laura Hunold, Sonja Milek, Christian Guebeli, Marko Kozomara-Hocke, Vera Neumeier, Angela Botteon, Jochen Klumpp, Jonas Marschall, Shawna McCallin, Reinhard Zbinden, Thomas M. Kessler, Martin J. Loessner, Matthew Dunne, Samuel Kilcher. Engineered reporter phages for detection of Escherichia coli, Enterococcus, and Klebsiella in urine. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-39863-x

It's a Question and Answer special this week. You supply the questions and we pose them to a panel of expert guests. Joining us this time, biologist and author Tom Ireland, marine scientist Liberty Denman, chemistry writer Philip Broadwith, and comedien Rosie Wilby. Like this podcast? Please help us by supporting the Naked Scientists

IS Phage therapy going to be the next big thing in medicine?  How does it work and what types of illness can it help with? Guest: Dr. Greg German, an infectious disease physician at St. Joseph's Hospital, part of Unity Health in Toronto Learn more about your ad choices. Visit megaphone.fm/adchoices

Even before the global COVID pandemic, simple mention of the word ‘virus' was likely to send shivers down most of our spines. But it turns out not all viruses are nasties. Ever heard of a phage? They are a type of virus that infect bacteria. Despite being one of the most common forms of life on Earth we still only know very little about them. However, current research suggests they may just be one of our greatest allies in the fight against superbugs. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Qu'est-ce que le microbiote ? Quel est son historique ? Comment décrire le microbiote intestinal ? Quels sont les champs d'application du microbiote ? Comment décrire le microbiote au cours des MICI ? Quelles sont les voies de modulation du microbiote pour contrôler l'inflammation ? Quels sont les résultats de ces différentes voies ? Quel message transmettre aux auditeurs ? Le Pr Philippe Seksik, gastro-entérologue à l'hôpital Saint-Antoine à Paris, directeur d'une unité de recherche Inserm sur le Microbiote – Sorbonne Université, répond à vos questions.   Invité : Pr Philippe Seksik – Hôpital Saint-Antoine – Paris https://www.aphp.fr/service/service-35-073  https://www.crsa.fr/equipe-philippe-seksik.html  Le Pr Seksik déclare des liens d'intérêts avec les laboratoires Takeda, Merck MSD, Biocodex, Ferring, Janssen, Amgen, Pfizer, Pileje, Fresenius Kabi et Abbvie.   L'équipe :
 Comité éditorial : Pr Lucine Vuitton, Pr Guillaume Bouguen, Pr Mathurin Fumery, Dr Maeva Charkaoui, Dr Mathieu Uzzan, Justine Amaro, Charlotte Mailhat, Justine Pollet Animation :  Pyramidale Communication Production : Pyramidale Communication Soutien institutionnel : Pfizer   Crédits : Pyramidale Communication, Sonacom

Antimicrobial resistance killed over a million people in 2019. That figure is expected to rise to ten million by 2050. Antibiotics remain vital to modern medicine, but this hidden pandemic of drug-resistant superbugs is driving scientists to explore possible alternatives. One type of therapy in particular is attracting serious scientific interest: bacteriophages. Phages are viruses that can destroy bacteria. In the 1920s, phage therapies were used widely against infections, but much of the world abandoned the idea following the discovery of penicillin. Some parts of the former Soviet Union, though, have continued to use phage therapies. What can governments and international companies learn from this medicine?Gilead Amit, The Economist's science correspondent, travels to the Eliava Institute in Tbilisi, Georgia to find out how phage therapies have been used there over the last century. He speaks to the director, Mzia Kutateladze, head of phage production, Vakho Pavlenishvili, and from the therapy centre: Davit Sturia, Lia Nadareishvili and Lana Abesadze. Barry Rud, a Canadian patient attending the clinic, discusses his experience. Steffanie Strathdee, who leads phage research at the University of California, San Diego, explains the renewed international interest in bacteriophages. Alok Jha, The Economist's science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

Antimicrobial resistance killed over a million people in 2019. That figure is expected to rise to ten million by 2050. Antibiotics remain vital to modern medicine, but this hidden pandemic of drug-resistant superbugs is driving scientists to explore possible alternatives. One type of therapy in particular is attracting serious scientific interest: bacteriophages. Phages are viruses that can destroy bacteria. In the 1920s, phage therapies were used widely against infections, but much of the world abandoned the idea following the discovery of penicillin. Some parts of the former Soviet Union, though, have continued to use phage therapies. What can governments and international companies learn from this medicine?Gilead Amit, The Economist's science correspondent, travels to the Eliava Institute in Tbilisi, Georgia to find out how phage therapies have been used there over the last century. He speaks to the director, Mzia Kutateladze, head of phage production, Vakho Pavlenishvili, and from the therapy centre: Davit Sturia, Lia Nadareishvili and Lana Abesadze. Barry Rud, a Canadian patient attending the clinic, discusses his experience. Steffanie Strathdee, who leads phage research at the University of California, San Diego, explains the renewed international interest in bacteriophages. Alok Jha, The Economist's science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

SpaceX Explosion Damages Environment Around Launch Site Last Thursday, SpaceX's South Texas facility was awash in noise and fire, as crowds gathered in South Padre Island and Port Isabel to watch Starship's first orbital launch. It was the largest and most powerful rocket ever made, standing at around 400 feet tall. Four minutes into the launch, SpaceX detonated the rocket after the SuperHeavy booster failed to separate from the Starship as planned. The launch destroyed the company's launch pad, spreading concrete up to three quarters of a mile away. Cameras left by YouTubers were either knocked down or destroyed in the rumble, along with some of the fence surrounding the launch pad's road-facing property. To read the rest, visit sciencefriday.com.   The Private Space Race Takes A Toll On Planet Earth After the SpaceX explosion last month, debris wasn't the only thing on the minds of Science Friday listeners. The following messages arrived in our inbox after we reported on 3-D printed rockets in March. It was interesting to hear you discuss 7 space launches in 5 days, and then just moments later the fact that we're not on track to reduce carbon emissions. My understanding is that rocket launches release huge amounts of carbon and other greenhouse gases. Story idea?—@RevBobIerien, Twitter Also regarding the 3-D rockets there wasn't any concern made for space pollution was there? I may have tuned out unhappily before the end. —Juanita H, email How much carbon do rockets contribute to global warming? —Robert C, email Very disappointing to hear the report of new “cheaper” 3D-printed rockets are available so that, like fast food pods and big gulps, we can now drop even more cheap **** into the ocean. And, *immediately* following a story about the new report on climate change, what exactly is the carbon footprint resulting from the ability of more people to more cheaply fire rockets into space? —David M, email Carbon isn't the big pollutant that comes from spaceflight, says Dr. Eloise Marais, associate professor in physical geography at University College London. Instead, black carbon or soot particles are generated and released directly into the atmosphere, alongside reactive nitrogen and nitrogen oxides. Dr. Marais joins Ira to talk about how much of an impact increased rocket launches could have on the atmosphere, and how that compares to the auto industry.    How To Combat The Antibiotic Resistance Crisis For years scientists have been ringing alarm bells about a global antibiotic resistance crisis. Now hospitals and healthcare facilities face the consequences: In the United States, there are 2.8 million antimicrobial-resistant infections every year, and more than 35,000 people die from these infections. Bacteria naturally try to outsmart the drugs designed to kill them, which causes treatments to become ineffective over time. While new antibiotics are made to respond to these resistant strains, the bacteria continue to evolve—creating a constant, and costly, cycle. There's a number of added factors driving the crisis, including antibiotic use in livestock and the general overprescription of antibiotics. About 1 in 3 antibiotic prescriptions in outpatient settings like urgent care or emergency departments are unnecessary. Scientists are struggling to keep up with the need to replace antibiotics that no longer work. It's a never ending game of catch up. Ira discusses some of the possible solutions to this vexing problem and takes listener questions with Dr. Victor Nizet, faculty lead of the Collaborative to Halt Antibiotic-Resistant Microbes at the University of California San Diego and Dr. Eddie Stenehjem, executive vice chair of medicine at the University of Colorado.   Are Phages A New Page In Medicine? One of the many possible solutions to the global antibiotic resistance crisis is an old idea that's new again—bacteriophages, or phages for short. Phages are viruses that exist solely to kill bacteria and are abundant in nature. While scientists first discovered phages' ability to treat bacterial infections about a century ago, there's been little interest in turning them into a treatment for patients with antibiotic resistant infections—until recently. Ira talks with Dr. Graham Hatfull, professor of biotechnology at the University of Pittsburgh about the latest in phage science.   Transcripts for each segment will be available the week after the show airs on sciencefriday.com.

Join Callum with guests Andrew Seaton, Marianna Avellar, Hannah Pymont, Eva Garmendia, Sanjay Patel and Dave Hettle live from ECCMID 2023. ECCMID sessions discussed:- Fairytales or reality, checking some eminence paradigms for treatment of severe infections- Neglected tropical skin diseases- Non-canonical approaches to treatment of infections- Paediatric interactive cases: dilemmas for the microbiologist and infection specialist- Clinical grand roundFor the AMR studio podcast: https://www.uac.uu.se/the-amr-studio/ BSAC paediatric pathways: https://bsac.org.uk/paediatricpathways/Music: https://pixabay.com/music/acoustic-group-outrigger-144123/Support the showQuestions, comments, suggestions to idiotspodcasting@gmail.com or Tweet us @IDiots_podPrep notes for completed episodes can be found here: https://1drv.ms/u/s!AsaWoPQ9qJLShugmB2EOm8FMePNBtA?e=IKApb5If you are enjoying the podcast please leave a review on your preferred podcast app!Feel like giving back? Donations of caffeine gratefully received!https://www.buymeacoffee.com/idiotspod

Antibiotics stopped providing big gains for pharmaceutical companies decades ago, but as bacteria become more resistant to drugs, the world needs new classes of antibiotics to be discovered if we want to prevent the next global health crisis. Dr Tina Joshi, Associate Professor of Molecular Microbiology at the University of Plymouth explains that it's more likely antimicrobial resistance will kill large numbers of human beings before climate change does. Kasim Kutay, CEO of the investment fund Novo Holdings tells us that for big pharma companies, antibiotics are seen as a contribution to society rather than an investment that can provide a profit. How can firms be convinced to invest in an unprofitable product? We hear how Netflix might provide a good model and we explore research in Phages - a bacteria specialised in eating other bacteria. Phages are being championed by some as a potential substitute for antibiotics. One patient in Minnesota tells us Phages saved his life. Presenter / producer: Stefania Gozzer Image: Dr Tina Joshi; Credit: Dr Tina Joshi

Healthcare professionals are searching for new ways to fight bacterial infections as growing concerns around antibiotic resistance reach new heights. Though bacteriophages or phages—viruses that infect only bacteria—have long since captured scientists' attention, they are quickly gaining popularity as a new and promising therapeutic tool. In this episode, Graham Hatfull, professor of biological sciences at the University of Pittsburgh, speaks with host Deborah Borfitz about his team's research and diligent work to showcase phages as versatile therapeutic agents. Hatfull also talks about the impressive findings produced by experimental phage therapy clinical trials and the barriers that currently prevent phages from ubiquitous antibacterial clinical use. He discusses his team's efforts to sequence phages and build a therapeutic library, the role of phage therapy in combating tuberculosis and cystic fibrosis, and the novel benefits phages bring to transplant recipients. Hatfull also addresses the FDA's support of phage therapy through expanded access for compassionate use and the global push to enter phages into their first-ever randomized controlled trial.  Links from this episode:  Clinical Research NewzUniversity of Pittsburgh Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease SEA-PHAGES (Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science) FDA Expanded Access for Compassionate Use Phage Australia 

Welcome to The ohmTown Daily News Show (ODNS). The show is held live on https://www.twitch.tv/ohmTown/ at 6PM Eastern. I cover a selection of aggregated news articles and discuss them briefly with a perspective merging business, technology, and society.Episode: ohmTown Daily News Show for November 29th, 2022. (Episode 333)Articles Discussed:what-the-brightest-young-minds-in-real-estate-are-working-onmusicians-arent-losing-out-from-streaming-musicrussian-vodka-trademark-auction-gets-green-lightnetflix-top-10-wednesday-snaps-stranger-things-4-recordpoverty-linked-to-facebook-and-instagram-addictionthousands-of-phages-found-to-have-crispr-gene-editing-systempoverty-linked-to-facebook-and-instagram-addiction-in-teensenerza-is-developing-a-robot-named-boagta-was-a-game-about-playing-an-angry-dinosaursupreme-court-concerned

In this week's episode I spoke with Dr. Yug Varna, co-founder and CEO of Phyla. Together with his co-founder, they created the world's most advanced probiotic acne system. The other co-founder, Maria Cho, struggled to find an effective solution to treat her acne. Yug and Maria worked together to create a product that addressed her skin condition in a way other skincare doesn't. Using what they knew about the skin's microbiome, Dr. Varma and Dr. Cho developed Phylabioitics. Skin's Microbiome To prove the efficacy of the new product, they ran clinical trials on phages and how they affect microbiome diversity. Phages are part of the skin microbiome and are helpful in combating acne since they kill harmful bacteria. Dr. Varna has a Ph.D. in microbiology from Johns Hopkins University and conducted over 10 years of microbiome research at UCSF. His passion was looking for the technology to support his products.  He discusses the differences between the microbiome in our gut vs the skin's microbiome. The skin microbiome refers to the ecosystem of microbes on your skin, comparing it a rainforest. It helps protect you from pathogens that could affect your system and overall health.  Watch the episode on YouTube

YUG VARMA, PhD, is the cofounder and CEO of Phyla, the world's most advanced probiotic acne system. he has 10+ years of of microbione reseach experience including an extensive background in bio-organic chemistry, microbiology and synthetic biology. We talk about what the microbiome is, how it functions in the body and the use of 'Phages" to target the specific bacteria which cause acne. Dr. Varma's mission is to change the way we treat chronic bacterial diseased, and is working tirelessly to achieve his goal. He is clearly one of those individuals at the forefront of this relatively new field of microbiome research and solutions.   He has generously offered a discount on Phyla products, using the code explode when purchasing at www.phylabiotics.com

Roland Pease talks to two astronomers who began working on the James Webb Space Telescope more than two decades ago and have now seen the first spectacular results of their labours. Marcia Rieke of the University of Arizona and JWST's senior project scientist John Mather discuss the highlights of the first four images. Also in the programme, geologists discover precisely where on the Red Planet the most ancient Martian meteorite came from - we speak to Anthony Lagain whose detective work identified the crater from which the rock was ejected into space. And what causes vast areas of the Indian Ocean to glow with strange light - a rare and mysterious phenomenon known as 'milky seas'? The world is a step closer to understanding this centuries' old maritime enigma thanks to the crew of a yacht sailing south of Java, atmospheric scientist Steven Miller and marine microbiologist Kenneth Nealson. We are running out of ammunition against certain infections, as bacteria increasingly evade the antibiotics we've relied on for nearly a century. Could bacteriophages – viruses that hunt and kill bacteria – be part of the solution? In 2019, CrowdScience travelled to Georgia where bacteriophages, also known as phages, have been used for nearly a hundred years to treat illnesses ranging from a sore throat to cholera. Here we met the scientists who have kept rare phages safe for decades, and are constantly on the look-out for new ones. Phages are fussy eaters: a specific phage will happily chew on one bacteria but ignore another, so hunting down the right one for each infection is vital. Since then, we've lived through a pandemic, the medical landscape has been transformed, and interest in bacteriophages as a treatment option is growing throughout the world. We turn to microbiologist Professor Martha Clokie for updates, including the answer to listener Garry's question: could phages help in the fight against Covid-19?

We are running out of ammunition against certain infections, as bacteria increasingly evade the antibiotics we've relied on for nearly a century. Could bacteriophages – viruses that hunt and kill bacteria – be part of the solution? In 2019, CrowdScience travelled to Georgia where bacteriophages, also known as phages, have been used for nearly a hundred years to treat illnesses ranging from a sore throat to cholera. Here we met the scientists who have kept rare phages safe for decades, and are constantly on the look-out for new ones. Phages are fussy eaters: a specific phage will happily chew on one bacteria but ignore another, so hunting down the right one for each infection is vital. Since then, we've lived through a pandemic, the medical landscape has been transformed, and interest in bacteriophages as a treatment option is growing throughout the world. We turn to microbiologist Professor Martha Clokie for updates, including the answer to listener Garry's question: could phages help in the fight against Covid-19? Contributors: Prof Martha Clokie, University of Leicester Dr Naomi Hoyle, Eliava Phage Therapy Center Prof Nina Chanishvili, Eliava Institute Dr Eka Jaiani, Eliava Institute Presented by Marnie Chesterton Produced by Cathy Edwards and Louisa Field for the BBC World Service [Photo:Bacteriophages infecting bacteria, illustration. Credit: Getty Images]

Dr. Gwyn Beattie, a faculty member at ISU's PLPM Department, walks us through the science behind working with bacteriophages (or phages for short) as potential biocontrol agents and their implications for IPM.

Avec Rémy André

Bacteriophages are interesting viruses that target bacteria and have been used for therapeutic purposes. Recently, the emergence of antibiotic resistance has spurred a renewed interest in using these viruses or their products as therapeutic tools against recalcitrant human pathogens. AAC has also published a recent manuscript from ARLG to guide the use of phages in clinical practice. We will discuss with experts in the field the state-of-the-art in phage therapy. Objectives: • Understand the use of bacteriophages and their products for therapeutic purposes • Discuss the clinical applications of phages • Debate the barriers for developing of phages as therapeutic tools to treat multidrug-resistant infections Guests: • Vincent A. Fischetti, Ph.D, Professor and Director, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY. • Saima Aslam, MBBS, Professor of Medicine, University of California San Diego, San Diego, CA. • Anthony Maresso, PhD. Professor and Founder of TAILOR Labs, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX. This episode of Editors in Conversation is brought to you by the Antimicrobial Agents and Chemotherapy Journal and hosted by AAC Editor in Chief, Cesar Arias. AAC is available at https://asm.org/aac. Follow Cesar on twitter at https://twitter.com/SuperBugDoc for AAC updates. Subscribe to the podcast at https://asm.org/eic

Scientists now specifically what causes acne and how to cure it.  One specific bacteria called Cutibacterium acnes causes acne.  By targeting the bad bacteria and keeping and feeding the good bacteria on your face, your acne acne, redness and inflammation goes away.  Learn more here: phylabiotics.com Find Optimal Performance Podcast episodes, discounts on health optimization gear and learn about the work I do as a Life Coach and Performance Coach at Seanmccormick.com  In this episode we cover:    •Where does acne come from specifically? •Phages are your friends to keep skin healthy and vibrant •Clinical trials show specifically how acne can be treated.  •Harmful acne treatments like Acutane can cause depression and damage skin long-term •Controlling the growth of Cutibacteria acnes bacteria is how you eliminate acne •How stress, hormones, diet and genetics can increase the appearance of that acne causing bacteria      

Documentarian Will Battersby and his subject, Diane Shader Smith, discuss the life and words of Mallory Smith, a cystic fibrosis patient who lived longer than anyone expected, but kept a secret diary that chronicled her illness and the toll it took on her mental health. The conversation ranges from patient advocacy to mental health awareness to the best ways to effect change in the medical community.SALT IN MY SOUL will be released theatrically in New York (Cinema Village) and Los Angeles (Laemmle Royal) on January 21 followed by the VOD Release in the US, Canada, and UK & Ireland and key territories worldwide on January 25.Support the show (https://lovethepodcast.com/omnibusride)

Despite the modern age, diseases like dysentery (dih-suhn-teh-ree) continue to wreak havoc even outside…

We may think the magic in phage therapy is in the treatment. That is true. But to make this magic happen, collaborative team efforts is necessary to  together prepare the stage and get ready for the show. Dr. Sabrina Green is currently the director of R&D at Baylor college of medicine Tailorlabs 'https://www.bcm.edu/research/research-centers/tailor'. On this episode, we sit down and truly understand the steps required to develop a phage product and supply it to the patients. Happy Listening!

To claim credit for this episode, visit: Mayo Clinic Talks Podcast: Genes & Your Health Guests: Gina A. Suh, M.D. Host: Denise M. Dupras, M.D., Ph.D. What is Phage Therapy? When was it discovered? Where is it used? We know about antibiotics, antifungals, and antivirals, but this is a whole new world! Have no fear, this episode is here from the Genes & Your Health miniseries to help demystify all there is to know about Phages. Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.  

Livestock farmers use antibiotics to treat infections in their animals, and may also use them as a preventative. But overuse of antibiotics can create 'superbugs' - antimicrobial-resistant (AMR) bacteria which threaten human lives and wellbeing, as well as those of livestock animals.Presenters Brenda Coromina and Elliot Carleton explore one approach that ILRI scientists are taking to combat the AMR problem - phages. These 'bacteria-eating' viruses, which naturally exist in the environment, are being studied by ILRI scientists to develop an alternative treatment to antibiotics. They hear from 'phage hunters' Angela Makumi and Nicholas Svitek about how phages work, what makes them different from antibiotics, and what it will take to make phage therapy a reality.Could phages become our future weapon of choice against bacteria?Read more: Phages: The viruses that offer a sustainable alternative to antibiotic treatment in livestock

TWiM explores whether ‘rewilding' is a way to get back our missing gut microbes, and failure of bacteriophage therapy due to the production of neutralizing antibodies. Become a patron of TWiM. Links for this episode Gut microbiota through an evolutionary lens (Science) You're missing microbes (NY Times) There is no ‘healthy' microbiome (NY Times) Antibody limits bacteriophage therapy (Nat) Phage therapy on TWiEVO #44 Graham Hatfull on TWiV #87 TWiM Listener survey Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv  

Welcome to another episode of The AMR Studio! Dive in to learn the story of Dr. Luisa De Sordi, a microbiologist working with bacteriophages and gut bacteria to study the relationship between our digestive system, the microbiota and their associated phages. We also go through a brief history of phage therapy and its future ahead! On this occasion, we also bring you a packed news section covering a recent article looking into the impact of travel on the human resistome, and highlighting some other recent news and resources that we are sure you will enjoy. Have a lovely month! Check relevant links in the show notes at www.uac.uu.se/the-amr-studio/episode30/. Follow our updates on twitter on www.twitter.com/uac_uu with #theAMRstudio hashtag! Theme music by Henrik Niss: www.tinyurl.com/henriknissspotify.

In this episode, Dr. Sabrina Green discusses the clinical aspects of phage use. We start by going back to one of the first ever uses of phage for a bacterial infection before discussing how phages are used now. Dr. Green explains a wide range of details related to clinical phage use. Topics discussed include cases today where phages are used, the safety of phages for clinical use, regulatory considerations for phage therapies, the pros and cons of phages, how specific phages are matched to specific patients, and phage affordability. Dr. Green describes potential hurdles for widespread adoption such as convincing people that viruses can be good for you. For further reading see https://www.liebertpub.com/doi/10.1089/phage.2020.0007 and https://mbio.asm.org/content/12/1/e03474-20

Dr. Sabrina Green introduces the concepts of phages and phage therapy. She describes what phages are and gives us a bit of history on phage therapy, describing reasons why antibiotics were widely adopted despite phages being discovered first. She also discusses why phages have become so important in the light of emerging antibiotic resistant pathogens. Dr. Green explains the mechanisms of how phages work and how these mechanisms lend themselves well to, for instance, scaling to different types of infections and getting cleared from a person's system. Finally, we discuss how phages are discovered, such as through evolving phages and engineering phages. We learn about a specific paper Dr. Green authored involving finding novel phages from bird droppings. Finally, we discuss potential areas for bioinformatics contributions in the field of phages. Papers referenced include https://www.liebertpub.com/doi/10.1089/phage.2020.0007 and https://mbio.asm.org/content/12/1/e03474-20

This interview explains Biologix proprietary phage therapy that is showing success clearing Persistent Lyme Disease, or PLD and coinfections in a gentle way, even for the most sensitive of patients 45 days after treatment.  Kristina discusses with Dr. Hart what a potential patient might expect from treatment at Biologix and why phage therapy.  It does not treat known illnesses, rather supports the body in being able to do the work by providing the phages specific to each strain a patient presents.Phage is a holistic treatment that has the potential of supporting the body to clear a multitude of pathogens such as Lyme, cancer, COVID, viruses, parasites, and persisters.  A clinical study is underway to show the results of 30 patients.  It will be shared on Facebook @ Texas Lyme Alliance, Twitter @TexasLyme on online at www.TexasLymeAlliance.org.Did you know that your immune system should not be made solely responsible for killing the infections in your body? Phages—or viruses that do not infect human cells—are well-known entities whose sole purpose is to swarm host microbes and replicate themselves in order to attack and kill them. Using Induced Native Phage Therapy, we at the Biologix Center have discovered exactly how to access the bacteriophages (phages that attack bacteria), mycophages (phages that attack mold and fungi), and virophages (phages that attack other viruses) that already reside inside your body and induce them to eliminate, in most cases, all infectious microbes wreaking havoc there.**This is not medical advice.  Kristina Bauer has no conflicts of interest and is not paid for services.  Texas Lyme Alliance supports this work and also does not receive payment for services from Biologix or any of its entities.  Kristina or Texas Lyme Alliance's effort is to support patients through the sharing of information and education and does not recommend any treatment.  We want patients to heal, stay out of bed, and get back to life at work and in their families.For more information, contact the Biologix Center at www.BiologixCenter.com.  Subscribe for future educational videos on healing Lyme Disease by clicking the subscribe button and sharing this video.  Thanks for watching and good luck!Support the show