Inflammation of the mucous membrane that lines the sinuses resulting in symptoms
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In Western countries, type 2 inflammation is the underlying cause of CRSwNP in ~ 80% of patients. Credit available for this activity expires: 10/24/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/chronic-rhinosinusitis-nasal-polyps-reimagined-bridging-2025a1000saf?ecd=bdc_podcast_libsyn_mscpedu
Living with constant congestion, facial pressure, or a loss of smell can make daily life exhausting. For many people, these symptoms are more than just allergies or a lingering cold. They may be signs of chronic rhinosinusitis with nasal polyps (CRSwNP). Dr. Rohit Katial joins Kortney and Dr. G to unpack what CRSwNP really is, how it develops, and why type 2 inflammation plays such a key role. Together, they explain what's happening inside the sinuses, what symptoms to look for, and when it's time to see a specialist. What we cover about CRSwNP: What CRSwNP means: Chronic rhinosinusitis with nasal polyps is long-term inflammation of the nose and sinuses that lasts 12 weeks or more. What nasal polyps are: Soft, fluid-filled sacs (often “grape” or “pea” sized) that block airflow and lead to congestion and smell loss. Why it happens: Type 2 inflammation drives CRSwNP. Immune messengers like IL-4, IL-5, and IL-13 cause swelling and fluid buildup in the nasal lining. Who it affects: CRSwNP often overlaps with asthma, allergies, or aspirin sensitivity (AERD or Samter's Triad), making symptoms worse. When to seek help: If congestion, pressure, or loss of smell lasts more than 12 weeks, see an allergist or an ENT specialist. Early care can prevent sinus damage and improve breathing and quality of life. More episodes to support CRSwNP Ep. 101: What is Type 2 Inflammation? Ep. 102: Comorbidities of Type 2 Inflammation - Connecting the Dots Between Multiple Allergic Conditions Ep. 109: Tezepelumab & Nasal Polyps - Inside the WAYPOINT Phase III Trial ___ Made in partnership with The Allergy & Asthma Network. Thanks to AstraZeneca for sponsoring today's episode. This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.
Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, and Preeti Malani, MD, MSJ, Deputy Editor of JAMA, the Journal of the American Medical Association, for articles published from August 16-22 2025.
In this episode, host Dr. Dan Beswick speaks with Drs. Peter Hwang, Lirit Levi, and Amir Levi. They discuss the recently published Original Article: “Association between US Wildfires and Health Care Utilization for Acute Rhinosinusitis.” The full manuscript is available as open access in the International Forum of Allergy and Rhinology. Listen and subscribe for […]
How do we integrate biologics into the existing stepwise treatment model for chronic rhinosinusitis with nasal polyps (CRSwNP)? In this episode, Dr. Reena Mehta, an allergist from Uptown Allergy and Asthma in New Orleans, discusses the use of biologics for treating chronic rhinosinusitis with nasal polyps. ---SYNPOSISDr. Mehta elaborates on the common presentations of patients, the role of biologics such as dupilumab and tezepelumab, and the nuances of patient management post-sinus surgery. Dr. Mehta also covers the workup process, the significance of patient comorbidities like asthma and allergies, and the future perspectives on biologic treatments. Practical aspects of biologic therapy, including insurance hurdles, patient compliance, and the effectiveness of various biologics are thoroughly examined.---TIMESTAMPS00:00 - Introduction 02:27 - Understanding Chronic Rhinosinusitis with Nasal Polyps & Presentation05:22 - Workup and Management of Nasal Polyps07:31 - Treatment Options: Steroids and Biologics15:28 - Tezepelumab: A New Tool in the Toolkit25:03 - Side Effects and Safety of Biologics28:59 - Insurance and Approval Challenges36:14 - Long-Term Safety and Efficacy38:47 - Pediatric Considerations and Future Directions41:37 - Collaboration Between ENT and Allergy Specialists45:07 - Conclusion and Final Thoughts---RESOURCESDr. Reena Mehtahttps://uptownallergyasthma.com/allergist-dr-reena-mehta/
In this episode, host Dr. Sarah Wise speaks with Dr. Naweed Chowdhury. They discuss the recently published Original Article: “Long-Term Particulate Matter Exposure May Increase Risk of Chronic Rhinosinusitis With Nasal Polyposis: Results from an Exposure-Matched Study.” The full manuscript is available as open access in the International Forum of Allergy and Rhinology. Listen and […]
Better Edge : A Northwestern Medicine podcast for physicians
In this episode of Better Edge, Bruce K. Tan, MD, discusses the newest clinical practice guidelines for the surgical management of chronic rhinosinusitis (CRS). Dr. Tan covers how treatment paradigms have evolved over the past 15 years, from antibiotic-centric approaches to multifaceted strategies that recognize CRS as a complex inflammatory condition. He dives into the guidelines' recommendations on diagnoses, biologic therapies and multidisciplinary collaboration. Additionally, Dr. Tan shares insights on future directions for research and the promise of precision medicine in tailoring effective treatments for a range of patient profiles.
Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by authors Meghan Wilson, MD, and Jason Blakeley Hensler, MD, to discuss information on when to consider moving forward with surgical interventions for those who are evaluated and diagnosed with chronic rhinosinusitis. Based on the 2025 “Clinical Practice Guideline: Surgical Management of Chronic Rhinosinusitis” and is a companion publication to the full guideline. Click here to read the full article.
Editor-in-Chief Cecelia E. Schmalbach, MD, MSc is joined by the guideline group's chair Jennifer J. Shin, MD, SM, and co-author Dana Crosby, MD, MPH, for a discussion of key points from the “Clinical Practice Guideline: Surgical Management of Chronic Rhinosinusitis,” which published as a supplement to the June 2025 issue of Otolaryngology–Head and Neck Surgery. The guideline addresses critical questions about patient selection, timing of surgery, and the extent of surgical intervention needed for different chronic rhinosinusitis subtypes. Read the full article here.
In this episode, host Dr. Doug Reh speaks with Dr. Josh Levy. They discuss the recently published Review Article: “Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop”. The full manuscript is available online in the International Forum of Allergy and Rhinology. Listen and subscribe for free to […]
In this episode, host Dr. Sarah Wise speaks with Dr. Do-Yeon Cho and Dr. Brad Woodworth. They discuss the recently published Research Note: “Prevalence of Cystic Fibrosis Carrier Status in Chronic Rhinosinusitis Without Nasal Polyp”. The full manuscript is available online as Open Access in the International Forum of Allergy and Rhinology. Listen and subscribe […]
In this episode, host Dr. Doug Reh speaks with Dr. Mathew Geltzeiler. They discuss the recently published Original Article: “Rate of dupilumab use and symptom severity of patients with chronic rhinosinusitis with nasal polyposis after Draf 3 frontal sinusotomy”. The full manuscript is available online in the International Forum of Allergy and Rhinology. Listen and […]
CME in Minutes: Education in Rheumatology, Immunology, & Infectious Diseases
Please visit answersincme.com/YWD860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in rhinology discusses the use of biologics for the management of chronic rhinosinusitis with nasal polyps (CRSwNP). Upon completion of this activity, participants should be better able to: Identify key considerations for initiating a biologic therapy in patients with CRSwNP; Discuss the clinical impact of the latest data for novel approved biologics in CRSwNP; and Apply best practice approaches for management of biologics in patients with CRSwNP. This activity is intended for US healthcare professionals only.
In this episode, host Dr. Marc Dubin speaks with Dr. Peter Manes. They discuss the recently published Original Article: “Assessment of conflicts of interest in literature on monoclonal antibodies for chronic rhinosinusitis with nasal polyposis using the Open Payments Database”. The full manuscript is available online in the International Forum of Allergy and Rhinology. Listen […]
In this episode, host Dr. Sarah Wise speaks with Dr. Chadi Makary. They discuss the recently published Review Article: “Evaluation and treatment of rhinosinusitis with primary antibody deficiency in children: Evidence-based review with recommendations”. The full manuscript is available online in the International Forum of Allergy and Rhinology. Listen and subscribe for free to Scope […]
In this episode, host Dr. Doug Reh speaks with Dr. Eugene Chang. They discuss the recently published Research Article: “A prospective longitudinal study assessing the impact of rhinovirus and bacterial infections in acute exacerbations of chronic rhinosinusitis”. The full manuscript is available online in the International Forum of Allergy and Rhinology. Listen and subscribe for […]
Editor in Chief Cecelia E. Schmalbach, MD, MSc, is joined by author Ahmad R. Sedaghat MD, PhD, and Associate Editor Dana L. Crosby, MD, MPH, to discuss the possibility of chronic rhinosinusitis when allergies are assumed as outlined in the paper “When It's Not Allergic Rhinitis: Clinical Signs to Raise a Patient's Suspicion for Chronic Rhinosinusitis” which published in the September 2024 issue of Otolaryngology–Head and Neck Surgery. They compare the symptoms of chronic rhinosinusitis to those of allergies or related conditions, and where there is overlap. Click here to read the full article.
In this episode, host Dr. Amber Luong speaks with Dr. Amin Javer. They discuss the recently published Research Note: “SinoNasal Microbiota Transfer to treat recalcitrant chronic rhinosinusitis: A case series”. The full manuscript is available as Open Access in the International Forum of Allergy and Rhinology. Listen and subscribe for free to Scope It Out […]
In this episode, host Dr. Marc Dubin speaks with Dr. Vinay Rathi. They discuss the recently published Research Note: Spending, utilization, and coverage for chronic rhinosinusitis with nasal polyposis therapies among Medicare Advantage beneficiaries. Read the full article in the International Forum of Allergy and Rhinology. Listen and subscribe for free to Scope It Out […]
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In this episode, host Dr. Doug Reh speaks with Dr. Rod Schlosser. They discuss the recently published article: Surgical management of headache and facial pain/pressure in chronic rhinosinusitis: A systematic review and meta-analysis. Read the article in the International Forum of Allergy and Rhinology. Listen and subscribe for free to Scope It Out on Apple Podcasts, Google […]
In this episode, host Dr. Amber Luong speaks with Dr. Sarina Mueller They discuss the recently published article: Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps. Read the fully open access article in the International Forum of Allergy and Rhinology. Listen and subscribe for free to Scope It Out on Apple […]
Nasal spray approved for chronic rhinosinusitis; Endothelin receptor antagonist gains approval to lower blood pressure in hypertension; One-time stem cell treatment approved for metachromatic leukodystrophy; NASH treatment gains accelerated approval; New automated insulin delivery system for type 1 diabetes.
In this episode, host Dr. Sarah Wise speaks with Dr. Amarbir Gill. They discuss his recently published article: Health care disparities and chronic rhinosinusitis: Does neighborhood disadvantage impact outcomes in sinonasal disease? Read the article in the International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.
In this episode, host Dr. Amber Luong speaks with Dr. Ahmad Sedaghat. They discuss his recently published article: Determinants of physician assessment of chronic rhinosinusitis disease control using EPOS 2020 criteria and the importance of incorporating patient perspectives of disease control. Read the article in the International Forum of Allergy and Rhinology. Listen and subscribe […]
In this episode, host Dr. Marc Dubin speaks with Dr. Gurston Nyquist. They discuss his recently published article: Optimizing the timing of biologic and surgical therapy for patients with refractory chronic rhinosinusitis with nasal polyposis (CRSwNP). Read the article in the International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe […]
Credits: 0.50 AMA PRA Category 1 Credits™, 0.50 ABIM MOC or 0.65 AANP, including 0.65 AANP Pharm CME/CE Information and Claim Credit: https://www.pri-med.com/online-cme-ce/Podcast/acute-bacterial-rhinosinusitis Overview: In this 30-minute podcast tailored for medical professionals, navigate the nuances of Acute Bacterial Rhinosinusitis (ABRS) as expert faculty discuss differentiating symptoms from acute rhinosinusitis. Gain practical insights on constructing effective treatment plans for ABRS in adults and acute bacterial sinusitis in pediatric populations, offering valuable guidance for appropriate antibiotic use in these scenarios. Stay informed and enhance your clinical decision-making skills in managing these common conditions. Guest: Danielle Hebert, DNP, MBA, ANP-BC
In this episode, host Dr. Sarah Wise speaks with Dr. Bobby Tajudeen. They discuss his recently published article: Histopathologic features of biologic therapy nonresponders in chronic rhinosinusitis with nasal polyposis. Read the article in the International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.
On this episode, my good friend and colleague Alex Hovey, PA-C is sitting in for Cole this episode. We review the treatment of acute rhinosinusitis and pharyngitis. We mention some treatment options for symptom relief in patients with viral sinusitis and viral pharyngitis. We spend the majority of the episode covering the treatment algorithm for bacterial sinusitis and pharyngitis. We also used this episode to review some antibiotic clinical pearls. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for select episodes. For existing Unlimited (Gold) freeCE members, this CE option is included in your membership benefits at no additional cost! A password, which will be given at some point during this episode, is required to access the post-activity test. To earn credit for this episode, visit the following link below to go to freeCE's website: https://www.freece.com/ If you're not currently a freeCE member, we definitely suggest you explore all the benefits of their Unlimited Membership on their website and earn CE for listening to this podcast. Thanks for listening! We want to give a big thanks to our sponsor, High-Powered Medicine. HPM is a book/website database of summaries for over 150 landmark clinical trials. You can get a copy of HPM, written by Dr. Alex Poppen, PharmD, at the links below: Purchase a subscription or PDF copy - https://highpoweredmedicine.com/ Purchase the paperback and hardcover - Barnes and Noble website We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable PowerPoint slides for each lecture. You can find our account at the website below: www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media platforms - @corconsultrx This podcast reviews current evidence-based medicine and pharmacy treatment options. This podcast is intended to be used for educational purposes only and is intended for healthcare professionals and students. This podcast is not for patients and not intended as advice or treatment.
In this episode, host Dr. Doug Reh speaks with Dr. Lauren Roland and Dr. Edward Kuan. They discuss their recently published article: Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence-Based Review with Recommendations Read the article in the International Forum of Allergy and Rhinology. Listen and subscribe for free […]
In this episode, host Dr. Mark Dubin speaks with Dr. Jose Mattos and Dr. Spencer Payne. They discuss their recently published article: Evaluation and workup of immunodeficiencies in recurrent acute rhinosinusitis: A scoping review. Please note that an unedited version of this episode posted in error earlier this month. Wiley sincerely apologizes for this error. […]
Commissioned by the Allergy, Asthma and Immunology Committee, Joshua M Levy, MD, MPH and Bruce K. Tan, MD discuss mechanisms and biomarkers of endotypes in chronic rhinosinusitis. Subjects covered by this podcast include identification of types of inflammation, geographic variations in endotypes, and methods utilized to address different endotypes.
JAMA Pediatrics Editors' Summary by Dimitri A. Christakis, MD, MPH, Editor in Chief, and Alison A. Galbraith, MD, MPH, Associate Editor, for the April 3, 2023, issue. Related Content: Effect of an Intranasal Corticosteroid on Quality of Life and Local Microbiome in Young Children With Chronic Rhinosinusitis Changes in Body Mass Index Among School-Aged Youths Following Implementation of the Healthy, Hunger-Free Kids Act of 2010
Matt Rank, MD, FAAAAI, the lead author of new guidelines for chronic rhinosinusitis with nasal polyposis, offers tremendous insight regarding these recommendations and how to apply them to clinical care.
Deadly fungus! This can kill a patient fast. Can you recognize the imaging features in time? In this week's podcast, Dr. Ross Frederick summarizes a very important paper on Invasive Fungal Sinusitis- don't miss this one! Deadly Fungi: Invasive Fungal Rhinosinusitis in the Head and Neck. Kurokawa and Kurokawa et al. RadioGraphics 2022; 42:2075–2094.
In this episode, host Dr. Amber Luong speaks with Dr. Amar Miglani. They will discuss article: A comparative analysis of endoscopic sinus surgery versus biologics for treatment of chronic rhinosinusitis with nasal polyposis. Read the article in International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.
PeerView Family Medicine & General Practice CME/CNE/CPE Video Podcast
Go online to PeerView.com/TJV860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Chronic rhinosinusitis with nasal polyps (CRSwNP) is one phenotype of CRS that is driven by type 2 inflammation and is particularly difficult to manage, especially when it occurs comorbidly with asthma, as is the case in up to 60% of patients with CRSwNP. However, biological agents that target type 2 inflammation and are already approved for other indications (eg, asthma, atopic dermatitis) have begun to emerge as available therapeutic options for CRSwNP. In this activity, Dr. Anju T. Peters shares her expertise in optimal clinical decision-making for patients with CRSwNP that is based on the latest evidence, best practice recommendations, and effective interdisciplinary collaboration. Upon completion of this activity, participants should be better able to: Identify patients with severe, inadequately controlled CRSwNP who would derive benefit from targeted biologic therapy; Assess patients with CRSwNP for comorbid conditions such as asthma and atopic dermatitis based on the relationship between CRSwNP and other type 2 inflammatory disorders; Employ a multidisciplinary approach to the treatment of patients with CRSwNP according to practice guidelines and the latest clinical evidence
Go online to PeerView.com/TJV860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Chronic rhinosinusitis with nasal polyps (CRSwNP) is one phenotype of CRS that is driven by type 2 inflammation and is particularly difficult to manage, especially when it occurs comorbidly with asthma, as is the case in up to 60% of patients with CRSwNP. However, biological agents that target type 2 inflammation and are already approved for other indications (eg, asthma, atopic dermatitis) have begun to emerge as available therapeutic options for CRSwNP. In this activity, Dr. Anju T. Peters shares her expertise in optimal clinical decision-making for patients with CRSwNP that is based on the latest evidence, best practice recommendations, and effective interdisciplinary collaboration. Upon completion of this activity, participants should be better able to: Identify patients with severe, inadequately controlled CRSwNP who would derive benefit from targeted biologic therapy; Assess patients with CRSwNP for comorbid conditions such as asthma and atopic dermatitis based on the relationship between CRSwNP and other type 2 inflammatory disorders; Employ a multidisciplinary approach to the treatment of patients with CRSwNP according to practice guidelines and the latest clinical evidence
Go online to PeerView.com/ZFR860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this interactive activity, an expert in chronic rhinosinusitis with nasal polyps discusses how to identify and develop treatment plans for patients with the disease. With a focus on multidisciplinary care and treatment guidelines, the activity will test learners' knowledge about the latest biologic therapies. Upon completion of this activity, participants should be better able to: Identify patients with severe, inadequately controlled CRSwNP to determine eligibility for targeted biologic therapy; Assess patients with CRSwNP for comorbid conditions such as asthma and atopic dermatitis based on the relationship between CRSwNP and other type 2 inflammatory disorders; and Develop treatment plans for patients with CRSwNP according to practice guidelines and the latest clinical evidence as part of a multidisciplinary approach.
PeerView Family Medicine & General Practice CME/CNE/CPE Video Podcast
Go online to PeerView.com/ZFR860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this interactive activity, an expert in chronic rhinosinusitis with nasal polyps discusses how to identify and develop treatment plans for patients with the disease. With a focus on multidisciplinary care and treatment guidelines, the activity will test learners' knowledge about the latest biologic therapies. Upon completion of this activity, participants should be better able to: Identify patients with severe, inadequately controlled CRSwNP to determine eligibility for targeted biologic therapy; Assess patients with CRSwNP for comorbid conditions such as asthma and atopic dermatitis based on the relationship between CRSwNP and other type 2 inflammatory disorders; and Develop treatment plans for patients with CRSwNP according to practice guidelines and the latest clinical evidence as part of a multidisciplinary approach.
Go online to PeerView.com/ZFR860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this interactive activity, an expert in chronic rhinosinusitis with nasal polyps discusses how to identify and develop treatment plans for patients with the disease. With a focus on multidisciplinary care and treatment guidelines, the activity will test learners' knowledge about the latest biologic therapies. Upon completion of this activity, participants should be better able to: Identify patients with severe, inadequately controlled CRSwNP to determine eligibility for targeted biologic therapy; Assess patients with CRSwNP for comorbid conditions such as asthma and atopic dermatitis based on the relationship between CRSwNP and other type 2 inflammatory disorders; and Develop treatment plans for patients with CRSwNP according to practice guidelines and the latest clinical evidence as part of a multidisciplinary approach.
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In this episode, host Dr. Doug Reh speaks with Dr. Rod Schlosser. They will discuss article: Eustachian tube dysfunction (ETD) in chronic rhinosinusitis with comparison to primary ETD: A systematic review and meta-analysis. Read the article in International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.
In this episode, host Dr. Amber Luong speaks with Dr. Naweed Chowdhury. They will discuss article: Association of cytokine profile with prior treatment failure and revision surgery in chronic rhinosinusitis. Read the article in International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.
In episode 514, James and Mike invite Betsy Thomas to the podcast for the first time. We look at a very common condition that many of us have at some point in our lives – allergic rhinosinusitis. We go over the best available evidence for the oral antihistamines and try to figure out which one […]
Are you someone who has never had allergies before and is feeling the effect? Allergy season is stronger than ever before. Learn more about NAC, a supplement that can help with your allergies today! Take advantage of an exclusive podcast offer today by visiting http://www.invitehealth.com/podcast. For more information on the products or studies mentioned in this episode, as well as a complete transcript of the audio, click here.
Refer to headmirror.com (www.headmirror.com/toc-podcast) to review all podcasts, organized by subspecialty topic and searchable by keywords.
In this episode, host Dr. Amber Luong speaks with Dr. Ralph Metson. They will discuss article: Endoscopic sinus surgery for chronic rhinosinusitis: 22-item Sino-Nasal Outcome Test 5-year results. Read the article in International Forum of Allergy and Rhinology. Listen and subscribe for free on Apple Podcasts , Google Podcasts and Subscribe on Android.
This episode covers nasal polyps.Written notes can be found at https://zerotofinals.com/surgery/ent/nasalpolyps/ or in the ear, nose and throat section of the Zero to Finals surgery book.The audio in the episode was expertly edited by Harry Watchman.