AJT Highlights

Host Roz is joined by new co-host Alberto Sanchez-Fueyo, MD, PhD to discuss the key articles of the June issue of the American Journal of Transplantation. Dr. Sanchez-Fueyo is a Professor of Hepatology, and the Academic Director of the Institute of Liver Studies, King's College, London. [02:51] Recipient toll-like receptor 4 determines the outcome of ischemia-reperfusion injury in steatotic liver transplantation in mice [10:47] Association between everolimus combination therapy and cancer risk after liver transplantation: A nationwide population-based quasi-cohort study [21:35] Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch Editorial: Equitable allocation through human leukocyte antigen eplet matching: A promising strategy with several challenges [32:51] Impact of the lung allocation system score modification by blood type on US lung transplant candidates Editorial: From flawed to fairer: Reducing blood type bias in lung transplant allocation Recommended article: The economic value of a transplant nephrologist: The case for improving compensation models

In this specialty podcast, Dr. Alissar El Chediak is joined by Dr. Jon Odorico and Dr. Ron Parsons to discuss the current state of pancreas transplantation, identify barriers and strategies for referral and candidate selection, and discuss solutions to address the decline in procedures. Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern Medical Center. Jon Odorico, MD is a transplant surgeon at the University of Wisconsin. Ron Parsons, MD is a transplant surgeon at the University of Pennsylvania.   References: Generating strategies for a national comeback in pancreas transplantation: A Delphi survey and US conference report

In this Specialty Podcast, Dr. Alejandra Mendoza is joined by Dr. Cameron Wolfe, infectious diseases specialist at Duke University, to discuss the growing concern of avian influenza (H5N1) in transplant recipients. Together, they explore the latest epidemiologic developments, potential risks to immunocompromised patients, and key considerations for clinicians managing solid organ and stem cell transplant recipients in the face of this evolving threat. Dr. Alejandra Mendoza is a transplant infectious diseases physician at the University of Utah. Dr. Cameron Wolfe is a professor of medicine in the division of infectious diseases at Duke University. References: Clinician Update on Human Cases of H5N1 and Influenza A Virus Surveillance (COCA Calls)

Host Roz is joined by Timucin Taner, MD, PhD and Dami Ko, PhD to discuss the key articles of the May issue of the American Journal of Transplantation. Dr. Timucin Taner is a professor of surgery at Mayo Clinic, Rochester, MN. Dr. Dami Ko is an assistant professor at the School of Nursing at Northeastern University. [02:51] Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients Editorial: Cognitive impairment after liver and kidney transplant: An easy way to check [14:16] Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression [20:46] Donor-specific immune senescence as a candidate biomarker of operational tolerance following liver transplantation in adults: Results of a prospective, multicenter cohort study Editorial: Acquired immune tolerance 2.0 [29:10] Major histocompatibility complex and peptide specificity underpin CD8+ T cell direct alloresponse Editorial: Direct and indirect allorecognition—not so different after all?

Host Roz is joined by Rene Bermea, MD and Gonzalo Sapisochin, MD, PhD to discuss the key articles of the April issue of the American Journal of Transplantation. Dr. Rene Bermea is an instructor at Harvard Medical School, and a transplant pulmonologist and intensivist. Dr. Gonzalo Sapisochin is an associate professor of surgery, abdominal transplant and surgical oncology at the University of Toronto, Canada. [04:31] Generalizability of kidney transplant data in electronic health records — The Epic Cosmos database vs the Scientific Registry of Transplant Recipients Editorial: Finding actionable information in the universe of data [14:17] High-dimensional profiling of immune responses to kidney transplant reveals heterogeneous T helper 1 and B cell effectors associated with rejection Editorial: Multimodal profiling of transplant rejection: Discerning the forest from the trees [23:02] The ability of an electronic nose to distinguish between complications in lung transplant recipients [34:58] The Rochester Protocol for living donor liver transplantation of unresectable colorectal liver metastasis: A 5-year report on selection, approval, and outcomes

Host Roz is joined by Ross Doyle, PhD to discuss the key articles of the March issue of American Journal of Transplantation. Dr. Ross Doyle is a consultant nephrologist at Mater Hospital in Dublin, Ireland. (Mentioned) A blood-based PT-LIFE (Pediatric Liver Transplantation-LIver Fibrosis Evaluation) biomarker panel for noninvasive evaluation of pediatric liver fibrosis after liver transplantation: A prospective derivation and validation study Editorial: Are we closer to abandoning protocol graft biopsies after pediatric liver transplantation? (Mentioned) Deceased donor urinary Dickkopf-3 associates with future allograft function following kidney transplantation [04:08] Cure models, survival probabilities, and solid organ transplantation for patients with colorectal cancer Editorial: When is it safe to transplant after cancer–adding data to the decision [11:05] Navigating challenges in recipient selection for end-chain kidneys [18:00] Severe ischemia-reperfusion injury induces epigenetic inactivation of LHX1 in kidney progenitor cells after kidney transplantation [28:31] The differential impact of early graft dysfunction in kidney donation after brain death and after circulatory death: Insights from the Dutch National Transplant Registry

Hosts Roz and Josh are joined by Dr. Adam Stewart to discuss the key articles of the February issue of the American Journal of Transplantation.   [00:02:38] A competing risks model to estimate the risk of graft failure and patient death after kidney transplantation using continuous donor-recipient age combinations [00:09:00] Donor-derived bartonellosis in solid organ transplant recipients from unhoused donors in Alberta [00:16:54] Contemporary prevalence and practice patterns of out-of-sequence kidney allocation Editorial: Out-of-sequence allocation: a necessary innovation or a new inequity in transplantation? Editorial: Ethical implications of prioritizing utility at all costs: The rise of out-of-sequence transplants [00:28:18] Association of nonstandardized model for end-stage liver disease score exceptions with waitlist mortality in adult liver transplant candidates

Hosts Roz and Josh are joined by Sergio Acuna, MD to discuss the key articles of the January issue of American Journal of Transplantation. Dr. Sergio Acuna is a clinical instructor in abdominal transplant surgery at the University of Alabama at Birmingham   [03:21] The dangerous precedent of censoring scientific dissemination [08:45] Long-term ex situ normothermic machine perfusion allows regeneration of human livers with severe bile duct injury Editorial: Time will tell: Employing long-term normothermic machine perfusion to gain new insight into bile duct regeneration [14:00] Probable antibody-mediated rejection in kidney transplantation is a rare and challenging phenotype to define: Findings from a single-center study [19:54] The relationship of microvascular inflammation with antibody-mediated rejection in kidney transplantation Editorial: Exploring microvascular inflammation and the spectrum of antibody-mediated rejection [25:56] Long-term persistence of seroprotection against measles following measles-mumps-rubella vaccination administered before and after pediatric liver transplantation [31:26] Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease

Hosts Roz and Josh are joined by Abraham Matar, MD to discuss the key articles of the December issue of American Journal of Transplantation. Dr. Abraham ‘Abe' Matar is a Transplant Surgery Fellow at the University of Minnesota   [02:15] Economic Evaluation of Weight Loss and Transplantation Strategies for Kidney Transplant Candidates with Obesity Editorial: Selecting Weight Loss Strategies for Kidney Transplant Candidacy: Weighty decisions [11:44] Electrostimulation suppresses allograft rejection via promoting lymphatic regulatory T cell migration mediated by lymphotoxin (LT)-LTb receptor signaling [18:57] Ischemia Reperfusion Responses in Human Lung Transplants at the Single Cell Resolution [28:36] The suggestion of mitigating disparity in the liver transplantation field among ABO blood type    

[02:08] Robotic living donor hepatectomy is associated with superior outcomes for both the donor and the recipient compared to laparoscopic or open - A single center prospective registry study of 3,448 cases [09:34] Public Attitudes to Xenotransplantation: A National Survey in the United States [18:09] Non-clinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1 [25:52] Establishing targets for goal-directed anesthesia in renal transplantation: a cohort analysis of high-saliency surgical time-courses. Editorial: Intraoperative blood pressure management during kidney transplantation: grafts under pressure. [36:53] Why partial heart transplantation could be regulated as organ transplantation

Hosts Roz and Josh are joined by Frances Lee, MD to discuss the key articles of the October issue of American Journal of Transplantation.   [00:02:31] Pre-transplant Use of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma: A Multicenter, Retrospective Cohort Study Editorial: Integrating immune check inhibitors in liver transplantation for hepatocellular carcinoma: The right time and the right patient [00:11:46] Association of Procurement Technique with Organ Yield and Cost Following Donation After Circulatory Death Editorial: Dawn Has Arrived, Illuminating Thrilling Opportunities and Fresh Challenges in a New Era of U.S. Transplantation [00:24:53] Common Definitions and Variables are Needed for the United States to Join the Conversation on Acute on Chronic Liver Failure [00:33:15] Enhanced role of multipair donor swaps in response to size incompatibility: The first two 5-way and the first 6-way liver paired exchanges [00:40:15] Comparing the prognostic performance of iBOX and biopsy-proven acute rejection for long-term kidney graft survival [00:48:22] Incomplete reporting of clinically significant acute rejection episodes in the National Kidney Transplant Registry

Hosts Roz and Josh are joined by Alissar El Chediak, MD to discuss the key articles of the September issue of the American Journal of Transplantation. Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern   [02:55] – Liver Machine Perfusion Technology: Expanding the Donor Pool to Improve Access to Liver Transplantation [08:01] – Editorial: Machine perfusion and liver transplant center behavior: Answers or more questions? [11:01] - Obesity, Organ Failure, and Transplantation: A Review of the Role of Metabolic and Bariatric Surgery in Transplant Candidates and Recipients. [18:48] – Virus Specific T Cell Therapy to Treat Refractory Viral infections in Solid Organ Transplant Recipients [25:08] - Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant [28:48] – Editorial: Virus-specific T-cell efficacy after solid organ transplantation: more questions than answers [34:05] - Successful BK virus–specific T cell therapy in a kidney transplant recipient with progressive multifocal leukoencephalopathy [37:50] - The prevalence of postacute sequelae of coronavirus disease 2019 in solid organ transplant recipients: Evaluation of risk in the National COVID Cohort Collaborative

Description:  Hosts Roz and Josh are joined by Maria Alejandra Mendoza, MD to discuss the key articles of the August issue of American Journal of Transplantation.   [01:57] Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes https://doi.org/10.1016/j.ajt.2024.02.022 [13:11] China Issued Rules on Human Organ Donation and Transplantation https://doi.org/10.1016/j.ajt.2024.04.002 [21:10] Advancing Mouse Models for Transplantation Research https://doi.org/10.1016/j.ajt.2024.01.006 [30:05] Differential induction of donor-reactive Foxp3+ Treg via blockade of CD154 vs. CD40 https://doi.org/10.1016/j.ajt.2024.03.033 [40:27] Total Robotic Liver Transplant: The Final Frontier of Minimally Invasive Surgery https://doi.org/10.1016/j.ajt.2024.03.030

Hosts Roz and Josh are joined by Mack Morris, MD to discuss the key articles of the July issue of American Journal of Transplantation. [03:33] Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases https://doi.org/10.1016/j.ajt.2024.02.023  [13:07] The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation https://doi.org/10.1016/j.ajt.2024.02.008  [24:30] Should advanced perfusion be the standard of care for donation after circulatory death liver transplant? https://doi.org/10.1016/j.ajt.2024.03.021  [32:20] Immunosuppression Withdrawal in Living-donor Renal Transplant Recipients Following Induction with Anti-thymocyte Globulin and Rituximab: Results of a Prospective Clinical Trial https://doi.org/10.1016/j.ajt.2024.03.007  [40:30] Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection https://doi.org/10.1016/j.ajt.2024.01.004 

In this specialty podcase, AJT Fellow and host David Cron is joined by Jesse Schold and Joel Adler to provide an overview policy evaluation in transplantation, including analytical approaches, pitfalls, and best practices. References Stewart et al. “Does anyone really know what (the kidney median waiting) time is?”   Noreen et al. “Augmenting the United States transplant registry with external mortality data: A moving target ripe for further improvement” Shifman et al. “Association of state Medicaid expansion policies with pediatric liver transplant outcomes”

Host Roz is joined by AJT Associate Editor Orla Morrissey, MD (Monash University) and AJT Editorial Fellow Elena-Bianca Barbir, MD (Mayo Clinic-Rochester). [3:16] The respiratory syncytial virus vaccines are here: Implications for solid organ transplantation [19:14] Association between cytomegalovirus viremia and long-term outcomes in lung transplant recipients [35:40] Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in 2 multiethnic urban cohorts [EDITORIAL] Untangling genetic and environmental risks in kidney transplant outcomes: The interplay of self-identified race, genetic ancestry, monogenic risk alleles, and socioeconomic factors [45:15] Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity [53:44] Outcomes in solid organ transplant recipients with a pretransplant diagnosis of melanoma

In this AJT specialty podcast, Luise Holzhauser, hosts Shelley Hall and Marie Budev to discuss the impact of the 2018 change in heart allocation and what the heart community can learn from experiences with continuous distribution of lung.

Host Roz is joined by AJT Executive Guest Editor Nadim Mahmud, MD, MPH (University of Pennsylvania) and AJT Editorial Fellow Tina Marinelli, MBBS, MPH&TM,  FRACP (Royal Prince Alfred Hospital).   [03:10] Semidirected Living Donors in Israel: Sociodemographic Profile, Religiosity, and Social Tolerance   [11:54] TCRseq Reveals Selected Donor-reactive CD8+ T cell Clones Resist Anti-Thymocyte Globulin Depletion after Kidney Transplantation   [18:47] Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation   [26:36] Surgical site infections after kidney transplantation are independently associated with graft loss   [38:26] Introduction to Virtual Special Issue, Insights into ACLF: From Pathogenesis to Interventions   [39:21] Immunopathogenesis of acute on chronic liver failure   [43:43] Geographic disparities in access to liver transplant for advanced cirrhosis: Time to ring the alarm!

Host Roz is joined by AJT Editor-in-Chief Emeritus Allan Kirk, MD, PhD, (Duke University) and AJT Editorial Fellow Laura Binari, MD (Vanderbilt University). [2:34] Abdominal computed tomography measurements of body composition and waitlist mortality in kidney transplant candidates [14:09] A2/A2B to B deceased donor kidney transplantation in the Kidney Allocation System era [24:01] Xenotransplantation Papers [25:07] Xenotransplantation experiments in brain-dead human subjects–A critical appraisal [28:11] The decedent model: A new paradigm for de-risking high stakes clinical trials like xenotransplantation [32:45] Exploring the single-cell immune landscape of kidney allograft inflammation using imaging mass cytometry

Host Roz is joined by AJT Editorial Board Member Alexandre Loupy, MD, PhD (Necker Hospital) and AJT Editorial Fellow Thiago J Borges, PhD (Massachusetts General Hospital). [2:39] Transplanting old organs promotes senescence in young recipients [11:33] The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics [15:45] The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts (Editorial) [18:12] The Banff process—Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation [20:25] Antiobesity pharmacotherapy to facilitate living kidney donation [27:04] Ambient air pollution is associated with graft failure/death in pediatric liver transplant recipients

Host Roz is joined by AJT Editorial Board Member John Greenland, MD, PhD (University of California, San Francisco) and AJT Editorial Fellow David Cron, MD, MS (Massachusetts General Hospital). [2:53] Pure laparoscopic donor hepatectomy: Experience of 556 cases at Seoul National University Hospital [11:26] Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation & Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response [20:28] Augmenting the Unites States transplant registry with external mortality data: A moving target ripe for further improvement (Editorial) How hard are the hard outcomes reported in national transplant registries? [32:25] Maintaining the permanence principle of death during normothermic regional perfusion in controlled donation after the circulatory determination of death: Results of a prospective clinical study

The podcast discusses the impact and implications the kidney allocation system (KAS 250) has had over kidney allocation in the United States, focusing on the effect on operational challenges, cold ischemic times, delayed graft function, and organ discard rates. Guest speakers include Joel Adler (Dell Medical School, University of Texas in Austin) and John Friedewald (Northwestern Memorial Hospital).

Host Roz is joined by AJT Editorial Board Member Michael Mengel, MD (University of Alberta) and AJT Editorial Fellow Mohammed Fallahzadeh, MD (Emory University). [2:43] Recurrent atypical antiglomerular basement membrane nephritis in the kidney transplant [14:26] Pretransplantation coronavirus disease 2019 vaccination requirements: A matched case-control study of factors associated with waitlist inactivation (Editorial) Coronavirus disease 2019 vaccine mandates and the Owl of Minerva [21:45] Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak [29:48] Risk for graft loss in pediatric and young adult kidney transplant recipients due to recurrent IgA nephropathy [37:07] De novo membranous nephropathy in a pig-to-baboon kidney xenograft: A new xenograft glomerulopathy

Host Roz is joined by AJT Editorial Board Member Emily Blumberg, MD (University of Pennsylvania) and AJT Editorial Fellow Dempsey Hughes, MD (Northwestern Medicine). [03:03] Predicting post–liver transplant outcomes in patients with acute-on-chronic liver failure using Expert-Augmented Machine Learning [10:34] Clinical features, treatment, and outcomes of mpox in solid organ transplant recipients: A multicenter case series and literature review [14:05] First case of rapidly fatal mpox from secondary (household) transmission in a kidney transplant recipient [15:28] A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: The Hipomenes study [22:55] A rational approach to guide cost-effective de novo donor-specific antibody surveillance with tacrolimus immunosuppression [30:04] (Editorial) Personalizing kidney transplant donor-specific antibody surveillance: The devil is in the details [33:20] Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial

In this specialty podcast, Arielle Cimeno, hosts Raymond Lynch and Amit Mathur to discuss recent trends and new initiatives to assess kidney utilization and organ procurement organization performance.  

Host Roz is joined by Ramsey Hachem, MD (Washington University School of Medicine in Saint Louis) and AJT Editorial Fellow Helen Tsai, MD (Montefiore Medical Center)  [03:30] Disseminated vaccine-induced varicella infection in a kidney transplant recipient [06:50] Safety and Immunogenicity of the Live-Attenuated Varicella Vaccine in Pediatric Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis [10:34] (Editorial) Balancing the live virus vaccine scales: protection vs risk [14:22] Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization [19:25] Lung transplantation despite preformed donor-specific anti-HLA antibodies: 9-year single-center experience [23:00] (Editorial) What is a Clinically Significant Donor-Specific Antibody Before Lung Transplantation? [25:38] Deceased Donor Kidneys from Higher Distressed Communities are Significantly Less Likely to be Utilized for Transplantation [35:11] (Editorial) Understanding the mechanisms and implications of the association between community distress and organ non-utilization [37:18] Sex as a Biological Variable: Mechanistic Insights and Clinical Relevance in Solid Organ Transplantation

Host Roz is joined by AJT Editorial Fellow Salil Kumar, MD (incoming Assistant Professor at MD Anderson Medical Center) [2:24] Importance of social vulnerability on long-term outcomes after heart transplantation [12:51] Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia [21:26] Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation [28:52] Validation of a prediction system for risk of kidney allograft failure in pediatric kidney transplant recipients: An international observational study [36:44] Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes

Host Roz is joined by AJT Editorial Board Member Kenneth Newell, MD, PhD (Emory University) and AJT Editorial Fellow Kyle Jackson, MD, PhD (Emory University) [2:45] Identifying and understanding variation in population-based access to liver transplantation in the United States [12:44] Intra-graft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics [18:21] Single-cell RNA sequencing reveals peripheral blood mononuclear immune cell landscape associated with operational tolerance in a kidney transplant recipient [22:20] Impact of allele-specific anti-HLA class I antibodies on organ allocation [28:12] Autoantibodies against DNA-topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses

In this specialty podcast, Carrie Thiessen, MD, PhD (University of Wisconsin-Madison) hosts Robert Montgomery, MD, PhD, (NYU Langone) and Muhammad Mohiuddin, MBBS, (University of Maryland) to discuss ethical issues related to informed authorization and informed consent for decedent kidney and human cardiac xenotransplants.

Host Roz is joined by AJT Editorial Board Member Sanjay Kulkarni, MD, (Yale School of Medicine) and AJT Editorial Fellow Luise Holzhauser, MD (University of Pennsylvania) [2:40] In a real-life setting, risk factors, Coronary artery calcium score and coronary stenosis at Computed Tomography Angiography are associated with MACE and all-cause mortality among kidney transplant candidates [16:00] The minimum weight and age of kidney donors: En bloc kidney transplantation from preterm neonatal donors weighing less than 1.2kg to adult recipients [24:35] Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation [31:07] Recipient Race Modifies the Association between Obesity and Long-term Graft Outcomes After Kidney Transplantation

In this AJT specialty podcast, Aly Strauss, hosts Allison Kwong and Manuel Rodriguez-Peralvarez to discuss MELD 3.0,  Gender-Equity Model for Liver Allocation (GEMA), and international efforts to eliminate gender disparities in allocation of liver transplants.    Bernards et al. AJT: https://pubmed.ncbi.nlm.nih.gov/35871752/   Kim et al. Meld 3.0: https://pubmed.ncbi.nlm.nih.gov/34481845/ Meld 3.0 calculator: https://medcalculators.stanford.edu/meld   Rodriguez-Peralvarez et al. GEMA: https://pubmed.ncbi.nlm.nih.gov/36528041/ GEMA calculator: http://gema-transplant.com/

Host Roz is joined by AJT Editorial Board Member Seth Karp, MD (Vanderbilt University Medical Center) and AJT Editorial Fellow Thiago Borges, PhD (Massachusetts General Hospital) [2:33] Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses [11:28] The tele-liver frailty index (TeLeFI): development of a novel frailty tool in patients with cirrhosis via telemedicine [21:18] The 20-year paradigm shift toward organ recovery centers: 2500 donors at Mid-America Transplant and broader adoption across the United States [33:13] Outcomes of lung and liver transplantation after simultaneous recovery using abdominal normothermic regional perfusion in donors after the circulatory determination of death versus donors after brain death [42:17] Stakeholders' perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients' consensus conference

Hosts Roz and Josh discuss the key articles of the June issue of American Journal of Transplantation. [1:30] The evolving use of biomarkers in heart transplantation: Consensus of an expert panel [9:49] Effects of in vivo CXCR4 Blockade and Proteasome Inhibition on Bone Marrow Plasma Cells in HLA Sensitized Kidney Transplant Candidates [16:50] An ethical analysis of obesity as a contraindication to pediatric liver transplant candidacy [23:53] Racial and ethnic disparities in psychosocial evaluation and liver transplant waitlisting

Host Roz and Josh are joined by AJT Editorial Fellow Scott Krummey, MD, PhD, to discuss the key articles of the May issue of American Journal of Transplantation.   [01:59] Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices   [11:36] Mutations In Latent Membrane Protein 1 of Epstein-Barr Virus are Associated with Increased Risk for Post-Transplant Lymphoproliferative Disorder in Children   [23:13] Impacts of removing race from the calculation of the Kidney Donor Profile Index   [31:49] The Association of Donor Hepatitis C Virus Infection with Three-Year Kidney Transplant Outcomes in the Era of Direct-Acting Antiviral Medications   [41:40] Time to discard the term “discard”  

Host Roz and Josh are joined by AJT Editorial Fellow Daniel Galvez Lima, MD, to discuss the key articles of the April issue of American Journal of Transplantation. [02:01] Successful pathways to liver transplant for undocumented immigrants, Kerznerman et al [10:30] Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial, Eelderink et al [18:07] ABO Genotyping finds more A2 to B kidney transplant opportunities than lectin-based subtyping, Joseph et al [29:15] Oxidative stress and related metabolic alterations are induced in ex situ perfusion of donated hearts regardless of the ventricular load or leukocyte depletion, Hatami et al

Host Roz is joined by AJT Editorial Fellow Aly Strauss, MD, to discuss the key articles of the March issue of American Journal of Transplantation.   [2:57] Milestones on the path to clinical pig organ xenotransplantation, Cooper & Pierson. [12:45] Infection and clinical xenotransplantation: Guidance from the Infectious Disease Community of Practice of the American Society of Transplantation, Mehta et al. [20:30] Addressing sex-based disparities in solid organ transplantation in the United States – a conference report, Sawinski et al. [33:45] A comparison of deprivation indices and application to transplant populations, Park et al.

In this specialty podcast, Katie Ross-Driscoll, PhD, MPH (Emory University) hosts Jon Snyder, PhD, MS (Scientific Registry of Transplant Recipients) to discuss the utility of registries in transplantation research, considerations for study design and analysis, and common errors when using registry data.

Hosts Roz and Josh are joined by AJT Editorial Fellow Zachary Yetmar, MD, to discuss the key articles of the February issue of American Journal of Transplantation.   [1:42] BK DNAemia and native kidney polyomavirus nephropathy following lung transplantation, Dube et al [12:05] Mortality among solid organ transplant recipients with a pretransplant cancer diagnosis, Hart et al [24:04] Does Anybody Really Know What (the Kidney Median Waiting) Time Is?, Stewart et al [32:37] Honoring the gift: the transformative potential of transplant-declined human organs, Albert et al [37:46] American Society of Transplant Surgeons recommendations on best practices in donation after circulatory death organ procurement, Croome et al

Hosts Roz and Josh are joined by AJT Editorial Fellow James Hendele, MD, to discuss the key articles of the January issue of American Journal of Transplantation.   [2:05] Days alive and out of hospital following liver transplant: Comparing a patient-centered outcome between DCD and DBD graft recipients, Frasco et al [11:03] Acute liver failure and unique challenges of pediatric liver transplantation amid a worldwide cluster of adenovirus-associated hepatitis, Banc-Husu et al [21:36] Information Design to Support Growth, Quality, and Equity of the U.S. Transplant System, Perakslis and Knechtle [29:01] Optimum timing of anti-thymocyte globulin in relation to adoptive Treg cell therapy, Muckenhuber et al

Hosts Roz and Josh are joined by AJT Editorial Fellow Quan Yao Ho, ​MBBS, MRCP (UK), MMed (S'pore), to discuss the key articles of the December issue of the American Journal of Transplantation.

Hosts Roz and Josh are joined by AJT Editorial Fellow Marlene Cano, MD, PhD to discuss the key articles of the November issue of American Journal of Transplantation.

Hosts Roz and Josh are joined by AJT Editorial Fellow Arielle Cimeno, MD, to discuss the key articles of the October issue of American Journal of Transplantation.

Hosts Roz and Josh are joined by AJT Editorial Fellow Ersilia M. DeFilippis, MD, to discuss the key articles of the September issue of American Journal of Transplantation.

Hosts Roz and Josh are joined by AJT Editorial Fellow Hirsh D. Trivedi, MD, MSc, to discuss the key articles of the August issue of American Journal of Transplantation.

Hosts Roz and Josh are joined by AJT Editorial Fellow Prince Singh, MBBS, FASN, FACP to discuss the key articles of the July issue of American Journal of Transplantation.

Hosts Roz and Josh discuss the key articles of the June issue of American Journal of Transplantation.

Hosts Roz and Josh are joined by Natalia Castillo Almeida, MD (University of Nebraska) and Beau Kelly, MD, MBA, FACS, FAST (DCI Donor Services and AST Board Member) to discuss the key articles of the May issue of American Journal of Transplantation.

Hosts Roz and Josh are joined by Dustin Carpenter, MD, MPH (Weill Cornell Medical Center) to discuss the key articles of the April issue of American Journal of Transplantation.

We are now more than two years into the COVID-19 pandemic, and yet many questions remain about how to approach solid organ transplant donors with COVID-19 infection. With the recent Delta and Omicron variant surges, the prevalence of COVID-19 positive donors has increased creating challenges for transplant centers needing to balance the risk of donor-derived infection with mortality on the waitlist. This special episode, hosted by AJT Fellow Dr. Carol Kao, features what is currently known on this topic as well as unique perspectives from the Italian experience by Dr. Paolo Grossi and the US by Drs. Ricardo La Hoz and Mike Green, moderated by Dr. Emily Blumberg.

Host Roz Mannon is joined by Carol Kao, MD (Washington University in St. Louis) to discuss the key articles of the March issue of American Journal of Transplantation.

Hosts Roz and Josh are joined by Satish Nadig, MD, PhD (Northwestern) to discuss the key articles of the February issue of American Journal of Transplantation.