Podcasts about Sensitization

Are you wondering why your chronic pain keeps getting worse — even when your scans are clear and your doctors say nothing is wrong?In this second installment of my three part podcast series inside The Chronic Pain Experience Podcast, we dive into one of the most frustrating questions people with persistent pain face:Why is my pain not going away — and why does it feel like it's getting worse over time?You'll learn about a key but often-overlooked piece of the chronic pain puzzle:Sensitization — when your nervous system becomes hypersensitive and overprotective, amplifying pain signals even in the absence of ongoing injury.We'll break down the science in simple terms, explore how pain pathways become overactive, and explain what you can do about it — especially if you've already tried everything and feel stuck.If you're living with fibromyalgia, CRPS, chronic back pain, pelvic pain, or pain after injury or surgery that just won't go away… this episode is for you.Rate, Review & Follow on Apple PodcastsIf this episode resonated with you, it would mean the world if you'd take a moment to rate and review The Chronic Pain Experience Podcast on Apple Podcasts.Your words help me reach more people who are living with pain and looking for a different path forward — one that leads to hope, healing, and a life well-lived.Click HERE then head to the show page, scroll to the bottom, tap the five stars, and write a quick review. Let me know what stood out most for you — I read every single one!Want to know what might really be keeping you stuck?Here's your next step:Step 1: Click here to take the Sensitization Quiz to see if your nervous system might be contributing to your pain.Step 2: Click here to book a Free Strategy Call with me. We'll talk about what's working, what's not, and what your next best step could be.

Interactive

An interview with Rosalito, Graphic Designer.  In this compelling interview, Rosalito shares how an upgraded Wi-Fi router triggered an immediate and life-altering reaction, leading her to recognize and eliminate wireless technology from her life. She reflects on years of anxiety, tinnitus, and immunity issues that she now connects to prolonged EMF exposure—all of which disappeared after removing wireless devices. Keith and Rosalito discuss the social isolation that comes with EMF sensitivity, the widespread denial of wireless addiction, and the medical validation she received that confirmed her only solution was complete avoidance. Rosalito now dedicates her work to raising awareness through her graphic design and website, Rosalito.Art, reaching those who might never actively seek out EMF information. They explore the societal implications of wireless dependence and the urgent need for education, shielding strategies, and informed remediation. Despite the hardships, Rosalito considers her experience a blessing, giving her clarity and purpose in protecting herself and helping others navigate the growing electromagnetic landscape. Hey this is Keith, this month I'm sharing 3 recent episodes from the EMF Remedy Premium podcast so you can see what we've been up to recently -- behind the pay wall.As I record this brief announcement, we have 118 episodes carefully crafted to support both the winning mindset and technical tactics needed to survive the now ubiquitous electromagnetic poisoning.Two new changes to our podcast subscription model -- We're now offering a 7-day free trial, for thoseSupport the showContinue the journey with the EMF Remedy Premium Podcast, with over 110 episodes and counting! Keith Cutter is President of EMF Remedy LLChttps://www.emfremedy.com/YouTube Channel: https://www.youtube.com/channel/UCp8jc5qb0kzFhMs4vtgmNlgKeith's SubstackThe EMF Remedy Podcast is a production of EMF Remedy LLC

Check out Dr. Mina's top picks for skin care here. Download the free eBook 'Skincare Myths Busted' here. Nails aren't just there to show off your favorite polish or nail art—they're a direct reflection of your overall health (yep, just like your skin). With the rise of gel nails, dip powders, and intricate manicures, it's more important than ever to find a balance between nails that look great and are healthy, too. While these trends can take your style to the next level, they also come with potential risks like allergic reactions, infections, and long-term nail damage.  Tune into this week's podcast with Dr. Carina Woodruff as she answers key questions on nail care, from the safety of manicures and pedicures to the risks at the nail salon. She shares her top 3 tips for beautiful nails and explains how the rise of at-home nail kits may be contributing to acrylate allergic contact dermatitis (ACD).  Key Takeaways: - Patch testing helps identify triggers for skin reactions. - Nail treatments can cause allergic reactions in unexpected areas. - Acrylic and gel nails can lead to sensitization over time. - Gentle nail care practices can prevent infections and damage. - Fungal infections can spread in nail salons if hygiene is poor. - Top coats in nail polish can harbor fungus and spread infections. - UV light used for gel nails can cause skin damage. - Choosing a reputable salon is crucial for nail health. - Taking breaks from nail treatments can promote healthier nails. - Regular check-ups with a dermatologist are important for nail health. In This Episode: (04:43) Introduction to Dermatology and Patch Testing (06:00) The Impact of Nail Treatments on Skin Health (08:33) Understanding Allergic Reactions and Sensitization (16:23) Nail Care Practices and Their Risks (18:31) Choosing the Right Nail Salon (20:57) Safety of Gel Nails and UV Light Exposure (23:24) Top Tips for Healthy Nails (25:28) Importance of Full Body Skin Checks Dr. Woodruff is the Director of the Epiphany Skin Allergy Institute in Dallas, Texas. Before joining Epiphany, Dr. Woodruff was an assistant professor of dermatology at the University of California, San Francisco where she was also Associate Director of the Contact Dermatitis Unit and Director of Medical Student Education. Her formal education and training include: Harvard University (Cambridge, MA) – BA, Social and Cognitive Neuroscience  Yale School of Medicine (New Haven, CT) – Doctor of Medicine Kaiser Permanente Medical Center (Oakland, CA) – Internal Medicine Internship University of California, San Francisco (San Francisco, CA) – Dermatology Residency Dr. Woodruff's ongoing involvement in research has facilitated a host of publications in major dermatology journals. She enjoys teaching medical students and residents and is a regular lecturer at national conferences. She co-founded VETTED Dermlab, a hypoallergenic skincare brand, and is an associate editor for the contact allergy journal Dermatitis.  Dr. Woodruff is originally from São Paolo, Brazil and is fluent in Portuguese. She grew up in Orlando, Florida. In her spare time, she enjoys exploring Dallas, traveling, and spending time with her family husband (Henry), daughter (Sienna - 5yo), son (Hughie- 3yo), and her King Charles Spaniel, Poppy. Find Dr. Carina Woodruff here: Instagram: https://www.instagram.com/drcarinawoodruff/?hl=en Linkedin: https://www.linkedin.com/in/carina-woodruff-md-faad-74b65ba4/ Clinic website: https://www.epiphanydermatology.com/location/dallas-tx/ https://vetteddermlab.com Follow Dr. Mina here:-  https://instagram.com/drminaskin https://www.facebook.com/drminaskin https://www.youtube.com/@drminaskin https://www.linkedin.com/in/drminaskin/ For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Website- https://www.atlantadermsurgery.com/ Email - scheduling@atlantadermsurgery.com Contact - (404) 844-0496 Instagram - https://www.instagram.com/baucomminamd/ Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.

Saint Lucia's National Anti-Money Laundering Oversight Committee took an important step in strengthening national security with a specialized Anti-Terrorism Training and Sensitization exercise. This training underscores Saint Lucia's commitment to aligning with international standards as the country continues to enhance its anti-terrorism financing framework.

Welcome to another enlightening episode of the StreetSmart Wisdom Podcast! I'm your host, Steve Stein, founder of Better Listen and Wisdom Feed Plus. Today, we have the immense privilege of conversing with Dr. Rick Hanson, a best-selling author and renowned speaker, whose work beautifully intertwines mindfulness, clinical psychology, and neuroscience. In this episode, we dive deep into the concept of sensitization and neuroplasticity, exploring how our inner world shapes our existence and overall well-being. Rick shares his journey—from a young boy grappling with feelings of inadequacy and social awkwardness to becoming a leading figure at the fascinating intersection of brain science and contemplative wisdom. We also reflect on the impermanence of life through the poignant metaphor of a sand mandala, and Rick offers street smart wisdom on how to navigate this ever-changing world with resilience and inner peace. This episode is rich with insights and practical takeaways that will inspire you to cultivate a deeper understanding of yourself and your place in the world. So, buckle up and get ready for a thought-provoking conversation with Dr. Rick Hanson, right here on the StreetSmart Wisdom Podcast.   TIMESTAMP: 00:00 Street Smart Wisdom Podcast with Steve Stein. 04:04 UCLA at 16, evolved to psychology intersection. 07:12 Socially awkward, turned to inner world exploration. 11:57 Everything is cloud-like; live with less attachment. 15:34 Life is transient, memories fade over time. 19:02 Skipping grades poses social challenges for students. 22:53 Realization: It was up to me. 26:39 Join WisdomFeed Plus for curated wellness content. 27:42 Begin your peaceful journey at surfingthetsunami.com   Connect with us: Facebook: https://bit.ly/FBpageWF Instagram: https://bit.ly/RealWisdomFeed WisdomFeed Website: https://bit.ly/WisdomFeedHome BetterListen Website: https://bit.ly/BetterListenWebsite

Atopic dermatitis is the single most common chronic condition in the world, but it's also the most misunderstood and mistreated. People who struggle with it endure years of discomfort, a drop in their quality of life, a revolving door of doctors, reams of blood tests and a multitude of treatments. These treatments often focus on food and finding out what they can stop eating to get better. Though this is well-intentioned advice, it is misguided. The food you eat isn't the root cause of eczema. Growing data show that eczema is what causes food allergies. This changes everything about how eczema is treated, and also how to prevent it in infants. For high-risk babies, early and frequent exposure to food can significantly reduce the chance of atopic dermatitis and potentially set them up for an allergy-free life. In this episode, I'm joined by the Chief Medical Officer at Snö Asthma & Allergy, Dr. Stuart Carr. He shares the truth about atopic dermatitis, and why there are more treatment options on the table other than avoiding certain foods and hoping for the best.  Things You'll Learn In This Episode  -Sensitization vs. true allergy  Food sensitivity and allergy are two very different things that often get mixed up. How do doctors determine if you're allergic to something? -The right way to restrict your diet  Many people use elimination diets to try and combat allergies. How do you do this without actually increasing your chance of allergy? -Early and often exposure is key Parents of infants prone to eczema often delay the introduction of certain foods, could this actually make the likelihood of allergy higher? -Food in mouth, but not on skin Atopic dermatitis patients think eating certain foods will trigger a reaction. What actually triggers a reaction?  Guest Bio Dr. Carr has been Chief Medical Officer at Snö Asthma & Allergy in Abu Dhabi since January 2019, having spent the previous 20 years in academic clinical allergy practice in Edmonton, Canada.  He was an Associate Clinical Professor at the University of Alberta, and is also a Past-President of the Canadian Society of Allergy and Clinical Immunology, and a reviewer for Allergy, Asthma & Clinical Immunology, the journal of the CSACI. His primary interests are pediatric asthma, food allergy, and eosinophilic esophagitis, and Dr. Carr is currently involved in a Canada-wide collaboration examining the safety and effectiveness of oral immunotherapy for peanut and other food allergies in preschool children. To learn more follow @allergydoc4kidz on Instagram   About Your Host Hosted by Dr. Deepa Grandon, MD MBA, triple board-certified physician with over 23 years of experience working as a Physician Consultant for influential organizations worldwide. Dr. Grandon is the founder of Transformational Life Consulting (TLC) and an outspoken faith-based leader in evidenced-based lifestyle medicine.   ​​TLC is presenting this podcast as a form of information sharing only. It is not medical advice or intended to replace the judgment of a licensed physician. TLC is not responsible for any claims related to procedures, professionals, products, or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services, or methods that might be referenced. Check out this episode on our website, Apple Podcasts, or Spotify, and don't forget to leave a review if you like what you heard. Your review feeds the algorithm so our show reaches more people. Thank you!

The Medical Disruptor podcast is back, and we're blowing the lid off the toxic secret that's driving the hidden epidemic of chronic illness. Is mold secretly sabotaging your sanity? Mold toxicity isn't just about musty basements. It's the hidden menace wreaking havoc on your brain, gut, and entire body.  From "unexplained" anxiety to autoimmune flare-ups and cognitive decline, mold's fingerprints are all over our most baffling health crises. In this mind-blowing episode, I sit down with mold mastermind Dr. Neil Nathan to expose the truth about this overlooked culprit.  We're diving deep into why your "mental health" issues might actually be mold colonizing your brain, the shocking link between mold and conditions like POTS that leave doctors scratching their heads, and how mold toxicity steals your vitality, hijacks your potential, and makes you question your own reality. Dr. Nathan isn't just a colleague - he's a true Medical Disruptor whose work has revolutionized how I unmask mold's destruction in my own patients. Here's the truth: Mold toxicity can derail your life, but it doesn't have to define it. Are you ready to stop being a victim of invisible toxins and become the ultimate biohacker of your own health?  Your toxic-free transformation starts now. Don't waste another day feeling dismissed by doctors or defeated by mystery symptoms.  You have more power to detox and heal than you ever imagined - it's time to tap into it. Tune in and arm yourself with the knowledge to reclaim your health from mold's toxic grip.    00:00 Introduction 03:00 Dr. Neil Nathan's Journey to Medicine  06:00 Transition to Mold and Mycotoxins 09:00 Exploring Chronic Pain and Fibromyalgia 12:00 Discovering Mold Toxicity 15:00 Collaborating with Dr. Shoemaker on Mold Treatment 18:00 Mold's Impact on Health and Sensitivity  21:00 Understanding Mast Cell Activation and Vagal Dysfunction 24:00 How Mold and Lyme Disease Are Linked 27:00 Treating Mold Toxicity: Steps and Challenges 30:00 The Role of Sensitization in Mold and Lyme Disease 33:00 Neurological Impact of Mold: Brain Fog and Dementia Risks 36:00 Supporting Sensitive Patients and Available Resources 39:00 Encouraging Patients to Seek Proper Treatment 42:00 Conclusion and Final Thoughts   Check us out on social media: drefratlamandre.com/instagram  drefratlamandre.com/facebook  drefratlamandre.com/tiktok

✅ Watch the MASTERCLASS on Low Back Pain & Sciatica. https://www.shapeshiftwellness.com/LBP-masterclass . If you have chronic low back pain or sciatica, it's easy to think that the pain is all coming from tissue damage like a disc bulge, a disc herniation, disc degeneration, tight muscles, or a pinched nerve. . Research shows that in most cases of chronic pain, a large portion of the pain is NOT from damage, but rather from inflammation and hypersensitization of the nerves in the muscles, joints, and disc, through a process called peripheral sensitization. . Peripheral sensitization can make chronic low back pain and sciatica much worse by creating hypersensitivity to normal, non-damaging activities or movements. This is crucial in understanding the difference between safe pain and unsafe pain during chronic low back pain and sciatica rehab. . . #lowbackpain #lowbackpainrelief#lowbackpainexercises #discherniation #sciaticarelief#sciatica #sciaticatreatment

Wards of the island's lone juvenile rehabilitative institution, The Boys Training Centre (BTC), have benefited from a transformative two-day Drug Awareness and Internet Safety Seminar to educate and empower young men about the dangers of drug and alcohol abuse.   Sponsored by the Army's Gift to Saint Lucia Project, an affiliate of the Army Winehouse Foundation, the workshop underscored the critical importance of making informed and responsible decisions. Leanna Wallace, Acting BTC Manager, emphasized the workshop's significance, stating, "Most of the time, we are unaware of the long-term harm that even a small amount of rum or two puffs in a joint can do to our health. I hope that this training opens your eyes to the need to make responsible decisions when it comes to using drugs and alcohol."   By spreading awareness of drug abuse and internet addiction, the workshop aligns with the Army Winehouse Foundation's aim to reduce drug use among young people.   The Amy Winehouse Foundation is deeply rooted in the memory of Amy Winehouse, a gifted artist who loved Saint Lucia and tragically passed away at the age of 27 due to drug and alcohol abuse. Peta Cozier, Chair of Amy's Gift to Saint Lucia, highlighted the foundation's mission. "She had so much to live for, yet she swayed. It is so easy for someone to be led astray through drugs, alcohol, and cyberbullying as well. Therefore, it is important to push through music therapy, drug awareness, and internet awareness."   The Community Relations branch of the Royal Saint Lucia Police Force and the Substance Abuse Advisory Council Secretariat made presentations that provided the boys with critical information about the hard facts of internet safety and drug abuse. The boys also expressed and reinforced the messages through interactive dramatizations and skits.   Dr. Charmaine Hippolyte Emmanuel, Permanent Secretary in the Ministry of Equity, Social Justice, and Empowerment, advised the boys on the broader impacts of substance use. "Anything with a measure of alcohol is considered to be a substance. Taking in those things will alter the way you think and perceive things. As strong young men of tomorrow, we want to ensure you are physically and psychologically well."   Amy's Gift to Saint Lucia annually supports the BTC via its music programme, funding instruments, and a music instructor. The BTC plays a vital role in helping boys in conflict with the law become model citizens and reintegrate into society. This drug sensitization workshop is a testament to BTC's commitment to rehabilitating these young men successfully.   The Closing Ceremony was hosted on July 11, 2024, at the Daren Sammy Cricket Ground in Gros-Islet.

In this video, I take you step by step through a playful sensory sensitization exercise! This is another great way to use our external world to increase our internal awareness. It's also important in getting us thinking about the ways we have become desensitized as a result of trauma and what "waking up the senses" really means. I also share about how a client of mine recently used interoception to decide whether or not a relationship was working for her!#beyondsurviving #sexualabusesurvivor #nervoussystemregulation #interoception #usethesenses #internalawareness #incestsurvivor #healingsexualtrauma #foryou #viral #coachrachelsays #coaching #toolsthatwork #healing #sensitization #wakeupthesensesSupport this show http://supporter.acast.com/beyond-surviving. Hosted on Acast. See acast.com/privacy for more information.

Let's work on feeling the water.  Sensitization drills to highten your feel!#swimming #feelthewater #liquiddeathmainset @liquiddeath Visit www.nlscak.coach for additional practice videos. #swimming #swimcoach #nlscak #nlscakpracticevideo #usaswimming #worldaquatics #alaskaswimming #swimfaster #thelegsfeedthebear @usaswimming

Small and Medium-sized Enterprises (SMEs) are growing concerned over business interruptions and cyberattacks, especially in Germany.  There is a notable gap in organizational measures relating to information security despite current safeguards, particularly in the areas of awareness and emergency preparedness.Professor Margit Scholl from TH Wildau is leading research across an evolving landscape of cybersecurity threats. Her work highlights how important it is to equip SMEs in Germany with robust mechanisms to improve their security attitudes and their resilience against cyberthreats.Read the original article: doi.org/10.13140/RG.2.2.12630.22082 

In this episode, Okey Ndibe and Emeka Onyeagwa interview Weyimi Lube, a social commentator and advocate for good governance in Nigeria. They discuss Weyimi's love for reading, especially books by Nigerian authors, and how it has shaped her political consciousness. Weyimi shares her experiences using her voice to advocate for change during political campaigns and the influence of her parents on her values and leadership style. She also discusses the importance of having a support system to navigate challenges. The conversation explores the experience of bigotry and division leading up to the election, the day of the election, the violence and intimidation faced, and the aftermath and reflection on the events. The conversation covers topics such as support from the diaspora, the impact of a CNN appearance, transitioning to a new name, and the speaker's education and experience at university. Weyimi B. Lube discusses her experiences with different Heads of Department (HODs) during her studies and the impact they had on her perspective. She shares her thoughts on Obi's presidency and how she believes he would have been accountable to the youth if he had won. Weyimi emphasizes the importance of problem-solving and the need for balance in leadership and followership. She also discusses the tendency to normalize abnormalities in Nigeria and the need for effective communication. Weyimi expresses her concerns about the economic crisis in Nigeria and the dire situation faced by the people. She highlights the passion and apathy of Nigerian youth and the lack of reasoning in Nigerian politics. Weyimi calls for young people's involvement in politics and discusses the potential future of Nigeria. The conversation covers various topics related to politics and society in Nigeria. It emphasizes the need for the Labor Party to be actively involved in society and address the concerns of the people. Peter Obi's intentionality and his engagement with youth and women are highlighted as positive aspects. The role of social media in spreading messages and the importance of education and sensitization are discussed. The conversation also emphasizes the need for unity and addressing personal issues. The interview concludes with a discussion on relaxation and hobbies, as well as reflections on the interview itself. ------------------- Chapters: 00:00 - Introduction and Background 02:27 - Love for Books and Reading 07:07 - Influence of Reading on Political Consciousness 13:27 - Basic Understanding of Politics 16:22 - Using Voice to Educate and Mobilize 32:34 - Navigating Relationships and Repercussions 38:42 - Unity and Love in Nigeria 43:36 - The 2023 Presidential and National Assembly Elections 44:25 - The Day of the Election 46:03 - Emotional Impact of the Election 50:26 - Violence and Intolerance 56:13 - The Importance of Love and Unity 59:58 - Support from the Diaspora 01:04:16 - Reflections on the Election 01:14:23 - Choosing to Get Active 01:17:16 - Bullying and Support from the Diaspora 01:18:16 - The Power of Social Media and Diaspora Support 01:19:13 - The Emotional Connection and Support from the Diaspora 01:20:12 - People Flying Back to Nigeria to Vote 01:21:10 - The Impact of the CNN Interview 01:23:30 - The Personal Experience of the CNN Interview 01:24:59 - The Effect of the CNN Interview on Social Media 01:25:58 - Choosing a Name and Maintaining Authenticity 01:27:26 - The Significance of the Name 'Orishawemi' 01:28:52 - The Decision to Start a Podcast and Making an Impact 01:30:49 - The Impact of CNN and Managing Expectations 01:33:17 - The Isolation and Challenges of University Life 01:35:10 - Education and Experience at Ogun State University 01:37:31 - The Importance of Speaking Yoruba in University 01:38:00 - The Unique Experience of Ibogun Campus 01:40:20 - Living in Close Proximity with Family 01:41:43 - The Challenges of Socializing in University 01:44:08 - The Importance of Critical Thinking in Engineering 01:48:02 - Accountability and Vision for a President 01:49:27 - The Accessibility and Relatability of Peter Obi 01:51:06 - The Ability to Provide Feedback to Peter Obi 01:54:06 - The Impact and Accessibility of Peter Obi 01:55:01 - The Experience of Gaslighting and Complaints 01:55:56 - Tolerance and Normalizing Abnormalities 01:56:54 - Lack of Balance in Leadership and Followership 01:57:24 - The Impact of Economic Crisis on Daily Life 01:58:21 - Calling Out Flaws and Propaganda 01:59:50 - The Importance of Constructive Criticism 02:00:49 - The Need for Progress and Change 02:01:19 - Economic Crisis as an Excuse 02:02:14 - The Struggle of Daily Life and Financial Burdens 02:03:13 - The Impact of Economic Crisis on Burials 02:04:05 - Rising Cost of Rice and Minimum Wage Disparity 02:05:02 - The Passion and Passionate-ness of Nigerians 02:05:30 - The Lack of Reason and Absence of Judgment 02:06:57 - The Importance of Education and Formation 02:07:26 - The Irrationality and Animalistic Drive in Nigeria 02:08:52 - The Decline in Living Standards 02:09:18 - The Need for Overhaul and Change 02:10:06 - Existential Crisis and the Concept of Change 02:11:01 - The Importance of Being Proactive for the Next Election Cycle 02:13:04 - The Cycle of Apathy and Entrenched Parties 02:14:29 - Addressing Ethnic Cleansing and Speaking Out 02:15:30 - The Love for Tolerating Abuse and the Need for Change 02:16:28 - The Importance of Education and Sensitization 02:20:44 - The Flaws of the Labour Party and the Need for Intentionality 02:22:41 - The Importance of Youth Dialogues and Engaging with the People 02:24:07 - The Role of Peter Obi and the Need for Continuous Engagement 02:25:36 - The Responsibility of the People to Educate and Unlearn 02:27:02 - The Need for Unity and Addressing Personal Issues 02:28:31 - Relaxation and Enjoyment of Cartoons and Music ----------------------------- Stay Connected: Follow "The Offside Musings Podcast" on Substack for insightful articles accompanying our episodes: offsidemusings.substack.com Listen to all episodes of "The Offside Musings Podcast" on your favorite podcast platforms. Social Media: YouTube: The Offside Musings Podcast Facebook: TheoffsideMusingsPodcast Instagram: @the_offside_musings Twitter: @MusingsOffside TikTok: @Theoffsidemusingspodcast --- Support this podcast: https://podcasters.spotify.com/pod/show/the-offside-musings/support

OH NO! IT'S COME BACK! The habits we develop and the neuropathways that get created by a disordered state of anxiety mean that even long into recovery, an anxious person might be re-triggered by life events, stress, memories, or any number of expected issues. This is normal. If this happens, we can feel things again ... anxiety, anxiety symptoms, and scary thoughts. This is not failure, or returning to square one, or "doing it wrong". This is being human and alive. But exactly what has been re-triggered when this happens? How does a recovered person or nearly recovered person become re-sensitized to anxious sensations and thoughts? This week we're talking about how external events can re-trigger INTERNAL sensitization - the state where we treat how we feel and what we think as urgently important or even dangerous. When suddenly re-sensitized, what then? As you might expect, this episode goes into detail about the process of de-sensitizing oneself to your internal state, which isn't a process at all. It's OK to be re-triggered. The trick here is to steer clear of the usual traps - looking for steps, tools, and techniques for making the feelings go away. When re-sensitized, the object of the game is to de-sensitize as you did before by allowing, accepting, tolerating, and surrendering. Bring it all with you, do not launch into evasive action or retreat rituals, and you will likely find that de-sensitization happens much more quickly than you expect it to. --- Want to pre-order Josh's book, “And How Does That Make You Feel?”  ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://geni.us/JoshFletcher⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ---- If you love Disordered and think you might benefit from spending 30 full days in an everyday intensive small group recovery support group led by Josh and Drew,⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ check out Disordered Boost at https://disordered.fm/boost⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ----- Want to ask us questions, share your wins, or get more information about Josh, Drew, and the Disordered podcast? Visit us on the web at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://disordered.fm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Disclaimer: Disordered is not therapy or a replacement for therapy. Listening to Disordered does not create a therapeutic relationship between you and the hosts of the podcast. Information here is provided for psychoeducational purposes. As always, when you have questions about your well-being, please consult your mental health and/or medical care providers. If you are having a mental health crisis, always reach out immediately for in-person help.

Most people will have come across this term before, but what does it actually mean? Today, we'll be dissecting the terms microbiome and microbiota and looking at what can impact them. Sources for this episode: Amon, P. and Sanderson, I. (2017), What is the microbiome? Archives of Disease in Childhood- Education and Practice 102-258-261. Cremon, C., Barbaro, M. R., Ventura, M. and Barbara, G. (2018), Pre- and probiotic overview. Current Opinion in Pharmacology 43: 87-92. Kim, H., Sitarik, A. R., Woodcroft, K., Johnson, C. C. and Woratti, E. (2019), Birth Mode, Breastfeeding, Pet Exposure and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children. Current Allergy and Asthma Reports 19: 22. Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V. D., Sokol, H., Doré, J., Corthier, G. and Furet, J.-P. (2009), The Firmicutes:Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiology 9:123. Rautava, S. (2016), Early microbial contact, the breast milk microbiome and child health. Journal of Developmental Origins of Health and Disease 7(1): 5-14. Rees, T., Bosch, T. and Douglas, A. E. (2018), How the microbiome challenges our concept of self. PLoS Biology 16(2): e2005358. Sender, R., Fuchs, S. and Milo, R. (2016), Revised estimates for the number of human and bacteria cells in the body. PLoS Biology 14(8): e1002533. Tojo, R., Suárez, A., Clemente, M. G., de los Reyes-Gavilán, C. G., Margolles, A., Gueimonde, M. and Ruas-Madiedo, P. (2014), Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis. World Journal of Gastroenterology 20(41): 15163-15176. Vongsa, R., Hoffman, D., Shepard, K. and Koenig, D. (2019), Comparative study of vulva and abdominal skin microbiota of healthy females with high and average BMI. BMC Microbiology 19:16. Author unknown, NHS (date unknown), Irritable bowel syndrome (IBS) (online) (Accessed 16/11/2023).

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.549838v1?rss=1 Authors: Blaeser, A. S., Zhao, J., Sugden, A. U., Carneiro-Nascimento, S., Andermann, M. L., Levy, D. Abstract: Migraine headache is thought to involve the activation and sensitization of trigeminal sensory afferents that innervate the cranial meninges. However, this notion is based mainly on preclinical studies in anesthetized animals with surgically exposed meninges. Here, we used two photon calcium imaging via a closed cranial window in awake, behaving mice to investigate the responses of meningeal afferents that might lead to migraine pain using a preclinical model of migraine involving cortical spreading depolarization (CSD). A single CSD episode caused a second-slong wave of calcium activation that propagated across afferents and along the length of individual afferents. Surprisingly, few afferents exhibited prolonged activation or suppression following CSD. However, a specific subset of afferents - those sensitive to acute meningeal deformation - exhibited stronger activation during locomotion bouts. Moreover, following CSD, a subset of previously silent afferents developed sensitivity to locomotion-related meningeal deformation. Our data point to acute calcium signaling in meningeal afferents as a potentially critical nociceptive factor contributing to migraine pain and support the notion that enhanced responsiveness of meningeal afferents to local mechanical deformation of the meninges is the neural substrate underlying the worsening of migraine headache pain during physical activity. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode we have with us the famous TV presenter and broadcast journalist Sidra Iqbal. Sidra Iqbal is an internationally acclaimed journalist and infopreneur. She presently hosts and produces one of Pakistan's leading daily news shows. We have discussed some important issues related to media industry and Pakistan's future.We explored several captivating topics from her illustrious career, a journey filled with remarkable milestones that have shaped both her personal growth and professional success. Moving forward, we explore the profound influence media personalities can have on society and ask ourselves what impact we aspire to make in this ever-evolving industry.Speaking of evolution, prepare to be amazed when we discuss how social media has transformed people's perception. Be inspired by her remarkable story and find motivation in her success.#sidraiqbal #media #howdoesitwork 00:00  Highlights02:49  Media personality's desired influence04:51  Evolution of social media perception07:34  Career opportunities in media industry09:04  Sidra Iqbal's biggest achievement17:28  Brain drain: reasons and future perspective27:17  Why Bangalis and Afghani dislike Pakistanis?39:12  Unlocking Pakistani potential41:42  Sensitization focus in Pakistani TV showsDon't forget to subscribe and press the bell icon to catch on to some amazing conversations coming your way every week!Keep up with our podcast:Facebook: https://www.facebook.com/Howdoesitwor...Insta: https://www.instagram.com/howdoesitwo...Tiktok: https://vt.tiktok.com/ZSRYSy1K1/Follow ProPakistani:Facebook: https://www.facebook.com/ProPakistaniInsta: https://www.instagram.com/pro_pakistani/Twitter: https://twitter.com/ProPakistaniPKLinkedIn: https://www.linkedin.com/company/prop...You can also audio stream our podcast here:Google Podcast: https://bit.ly/3z6AGPiApple Podcast: https://apple.co/3b9GQGuSpotify: https://spoti.fi/3OFNm5H

Join us as we explore the interplay between feed forward and feedback in the somatosensory system. Learn how this impacts our ability to perform skilled movements and how our brain prepares for the next action. Find out how inhibition plays a crucial role in allowing us to venture forward in novel experiences. Check out DFX's learning journeys to build your clinicalreasoning skills with Tracy --> https://dfxlearningjourneys.thinkific.com/ Full transcription of our episode is available on ourwebsite. Timestamps:0:00:00 Introduction and revisiting the topic of praxis0:01:28 Difficulty of replicating human praxis in robots0:02:48 Somatosensory basis of dyspraxia0:05:01 Importance of enhancing somatosensation, movement, and vision0:05:41 The dynamic and solidified body map of the homunculus0:06:25 Purpose of somatosensory processing and sensory integrative processing0:07:49 Treating the whole, not just practicing the end products0:08:12 Understanding the homunculus and its dynamic nature0:10:04 Feed forward and feedback happening simultaneously0:11:35 Interplay between feed forward and feedback happening simultaneously in the brain0:12:22 Peripheral receptors learning in the neural network0:13:03 Neurodevelopmental changes in the peripheral and central nervous system0:13:45 Preparing the body for the next activity0:14:44 Sensitization of peripheral receptors in response to unexpected events0:16:12 Pre-emptive preparation of the brain in eye movement control0:17:19 Interplay between somatosensory, vestibular, and visual systems in response to uneven surfaces0:17:50 Importance of somatosensation as a perceptual layer that supports skilfulness0:18:58 The interplay between modulation and discrimination processing in novel experiences0:20:40 Treating the modulation issue to clear the slate for discrimination to become relevant0:21:57 Co-regulation through touch in discrimination processing0:22:25 The spreading activation of the homunculus enriching the body map0:23:10 The nervous system drawing somatosensory information to create inhibition and engagement0:23:41 The somatosensory system as the primary inhibitory system0:24:26 The whole process being somatosensory dependent0:24:42 The valence and tipping in the somatosensory system0:25:21 The role of the social engagement secretary in somatosensory modulation0:27:01 Co-regulation and the importance of a partner in somatosensory experiences0:29:20 The impact of not meeting a child's somatosensory needs on adaptation and efficiency0:29:54 The power of OT observations in shifting perceptions and supporting children's sensory needs0:34:20 The importance of separating modulation from discrimination in clinical reasoning for effective intervention0:34:54 The interplay between modulation, discrimination, cognition, and executive function in treatment. Connect with us: Instagram: https://www.instagram.com/spiritedconversations_ot/Facebook: https://www.facebook.com/spiritedconversationsOTYouTube: https://www.youtube.com/@spiritedconversations_OTWebsite: https://www.spiritedconversationspodcast.com/ Loved this episode and want an easy cost free way to support us?Subscribe to our youtube channel! Hosted on Acast. See acast.com/privacy for more information.

How can humanity use energetic communication and sensitization training to prepare us for whatever comes next? On this episode of The Science of Superpowers, Tonya Dawn Recla shares basic energetic communication concepts and explains the importance of the sensitization component. By integrating both constructs, we're able to learn how to align our communication at all levels and energetically express congruently. This opens us to awareness of how to activate and utilize our creative energy field and, ultimately, use our superpowers to change the world. Tap into these powerful episodes guaranteed to inspire a different perspective into a very different world.

How can humanity use energetic communication and sensitization training to prepare us for whatever comes next? On this episode of The Science of Superpowers, Tonya Dawn Recla shares basic energetic communication concepts and explains the importance of the sensitization component. By integrating both constructs, we're able to learn how to align our communication at all levels and energetically express congruently. This opens us to awareness of how to activate and utilize our creative energy field and, ultimately, use our superpowers to change the world. Tap into these powerful episodes guaranteed to inspire a different perspective into a very different world.

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Investigating Fabrication, published by LoganStrohl on May 18, 2023 on LessWrong. Note 1: This was originally published in 2021. I'm now re-publishing it in 2023 as the penultimate post in The Nuts and Bolts Of Naturalism, as a demonstration of the method. I intend to publish a collection of much-more-complete demonstrations in the future, and I plan for them to explicitly discuss each step as I've described it in the sequence. For now, though, I hope that this partial demo will give you a taste of one way the overall process can go.(For a similarly partial demo by someone other than me, check out "Maps of Maps, and Empty Expectations" by Nora Ammann.) Note 2: This essay was written in response to “Lies, Damn Lies, and Fabricated Options”. I expect it'll be pretty confusing to read this one without having read that one first. However, I'm not the boss of you, and it isn't obvious to me anyway which reading order is best overall. If prolonged confusion makes you grumpy, I recommend reading Duncan's essay first. But if you try it backwards, I'd love to hear how that goes. 1. Motivation When I read Duncan's essay "Lies, Damn Lies, and Fabricated Options," it seemed to me to point toward something that's worth knowing for real, rather than just worth knowing about. I think it does a good job of helping the reader build a new concept that could conceivably be taken as a hypothesis in important situations. The hypothesis is, “Perhaps this thing that seems to me like an option isn't really a possibility, and it only seems like one because I'm in the grips of a map/territory conflation.” (Or, at least, “Perhaps the person I'm arguing with thinks their made-up option is real because [etc.].”) But I wasn't satisfied with my new concept “fabricated options”. There were some super important questions that I'd need to answer before I could put it to use. For instance, Which situations are the crucial ones for promoting this hypothesis to attention? How do I actually move my mind to recognize that the option I'm considering might be fabricated? Once I've posed the hypothesis, how do I confirm or deny it? When I've successfully identified a fabricated option, how can I prevent the usual harm? And, my favorite: How can I stop making this kind of mistake in the first place? So I set out to investigate option fabrication (the act), and what my brain is up to in the moments just before a fabricated option appears. I hoped that if I could learn where fabricated options come from, and what they are made of, I'd be a long way toward answering many of the practical questions on my list. 2. Approach I did naturalism to this. (One of the reasons this essay felt worth writing and sharing is to give people more chances to see what naturalism looks like in practice.) I assumed that there's sometimes A Thing Going On in my brain that in some ways resembles what Duncan called "fabricated options", and that my default understanding of the Thing is worse than I'd prefer. I set out to observe the Thing myself, directly and in real time, and to gradually build my own understanding of whatever I found. I tried to observe the Thing both in the "field" (as it occurs naturally in the course of daily life) and in the "lab" (as it occurs when I deliberately create controllable conditions that might give rise to it). This was not a full naturalist study (which usually takes at least a month), but was instead a "let's see what comes of a week or two" dalliance. Still, it turned out to follow the arc of a mostly complete study: Sensitization, zooming in, zooming out, and experimentation. [ETA: Though I used different terms here, these correspond to Locating Fulcrum Experiences, Getting Your Eyes On, Collection, and Experimentation.] 3. Lab Work, Part 1 In accordance with the “try it immediately” heuristic, I ...

Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Investigating Fabrication, published by LoganStrohl on May 18, 2023 on LessWrong. Note 1: This was originally published in 2021. I'm now re-publishing it in 2023 as the penultimate post in The Nuts and Bolts Of Naturalism, as a demonstration of the method. I intend to publish a collection of much-more-complete demonstrations in the future, and I plan for them to explicitly discuss each step as I've described it in the sequence. For now, though, I hope that this partial demo will give you a taste of one way the overall process can go.(For a similarly partial demo by someone other than me, check out "Maps of Maps, and Empty Expectations" by Nora Ammann.) Note 2: This essay was written in response to “Lies, Damn Lies, and Fabricated Options”. I expect it'll be pretty confusing to read this one without having read that one first. However, I'm not the boss of you, and it isn't obvious to me anyway which reading order is best overall. If prolonged confusion makes you grumpy, I recommend reading Duncan's essay first. But if you try it backwards, I'd love to hear how that goes. 1. Motivation When I read Duncan's essay "Lies, Damn Lies, and Fabricated Options," it seemed to me to point toward something that's worth knowing for real, rather than just worth knowing about. I think it does a good job of helping the reader build a new concept that could conceivably be taken as a hypothesis in important situations. The hypothesis is, “Perhaps this thing that seems to me like an option isn't really a possibility, and it only seems like one because I'm in the grips of a map/territory conflation.” (Or, at least, “Perhaps the person I'm arguing with thinks their made-up option is real because [etc.].”) But I wasn't satisfied with my new concept “fabricated options”. There were some super important questions that I'd need to answer before I could put it to use. For instance, Which situations are the crucial ones for promoting this hypothesis to attention? How do I actually move my mind to recognize that the option I'm considering might be fabricated? Once I've posed the hypothesis, how do I confirm or deny it? When I've successfully identified a fabricated option, how can I prevent the usual harm? And, my favorite: How can I stop making this kind of mistake in the first place? So I set out to investigate option fabrication (the act), and what my brain is up to in the moments just before a fabricated option appears. I hoped that if I could learn where fabricated options come from, and what they are made of, I'd be a long way toward answering many of the practical questions on my list. 2. Approach I did naturalism to this. (One of the reasons this essay felt worth writing and sharing is to give people more chances to see what naturalism looks like in practice.) I assumed that there's sometimes A Thing Going On in my brain that in some ways resembles what Duncan called "fabricated options", and that my default understanding of the Thing is worse than I'd prefer. I set out to observe the Thing myself, directly and in real time, and to gradually build my own understanding of whatever I found. I tried to observe the Thing both in the "field" (as it occurs naturally in the course of daily life) and in the "lab" (as it occurs when I deliberately create controllable conditions that might give rise to it). This was not a full naturalist study (which usually takes at least a month), but was instead a "let's see what comes of a week or two" dalliance. Still, it turned out to follow the arc of a mostly complete study: Sensitization, zooming in, zooming out, and experimentation. [ETA: Though I used different terms here, these correspond to Locating Fulcrum Experiences, Getting Your Eyes On, Collection, and Experimentation.] 3. Lab Work, Part 1 In accordance with the “try it immediately” heuristic, I ...

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.31.534820v1?rss=1 Authors: Yi, J., Bertels, Z., Del Rosario, J. S., Widman, A. J., Slivicki, R. A., Payne, M., Susser, H. M., Copits, B. A., Gereau, R. W. Abstract: Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal hyperexcitability. Recent evidence suggests that human and rodent dorsal root ganglia (DRG), which contain the cell bodies of sensory neurons, differ in the expression and function of key GPCRs and ion channels; whether BK receptor expression and function are conserved across species has not been studied in depth. In this study, we used human DRG tissue from organ donors to provide a detailed characterization of bradykinin receptor expression and bradykinin-induced changes in the excitability of human sensory neurons. We found that B2 and, to a lesser extent, B1 receptors are expressed by human DRG neurons and satellite glial cells. B2 receptors were enriched in the nociceptor subpopulation. Using patch-clamp electrophysiology, we found that acute bradykinin increases the excitability of human sensory neurons, while prolonged exposure to bradykinin decreases neuronal excitability in a subpopulation of human DRG neurons. Finally, our analyses suggest that donor's history of chronic pain and age may be predictors of higher B1 receptor expression in human DRG neurons. Together, these results indicate that acute BK-induced hyperexcitability, first identified in rodents, is conserved in humans and provide further evidence supporting BK signaling as a potential therapeutic target for treating pain in humans. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.08.527340v1?rss=1 Authors: Torres-Rodriguez, J. M., Wilson, T. D., Singh, S., Chaudhry, S., Adke, A. P., Becker, J. J., Lin, J. L., Martinez Gonzalez, S., Soler-Cedeno, O., Carrasquillo, Y. Abstract: The spino-ponto-amygdaloid pathway is a major ascending circuit relaying nociceptive information from the spinal cord to the brain. Potentiation of excitatory synaptic transmission in the parabrachial nucleus (PbN) to central amygdala (CeA) pathway has been reported in rodent models of persistent pain. At the behavioral level, the PbN[->]CeA pathway has been proposed to serve as a general alarm system to potential threats that modulates pain-related escape behaviors, affective-motivational (but not somatosensory) responses to painful stimuli, aversion, and threat memory. Increased sensitivity to previously innocuous somatosensory stimulation is a hallmark of chronic pain. Whether the PbN[->]CeA circuit contributes to heightened sensitivity to somatosensory stimulation following an injury, however, remains unknown. Here, we demonstrate that activation of CeA-projecting PbN neurons contributes to injury-induced behavioral hypersensitivity but not baseline nociception in male and female mice. Using optogenetic assisted circuit mapping, we confirmed a functional excitatory projection from PbN[->]CeA that is independent of the genetic or firing identity of CeA cells. We then showed that peripheral noxious stimulation increases the expression of the neuronal activity marker c-Fos in CeA-projecting PbN neurons and chemogenetic inactivation of these cells reduces behavioral hypersensitivity in models of neuropathic and inflammatory pain without affecting baseline nociception. Lastly, we show that chemogenetic activation of CeA-projecting PbN neurons is sufficient to induce bilateral hypersensitivity without injury. Together, our results demonstrate that the PbN[->]CeA pathway is a key modulator pain-related behaviors that can amplify responses to somatosensory stimulation in pathological states without affecting nociception under normal physiological conditions. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

My guest this episode is Lex Fridman, Ph.D., a Research Scientist at the Massachusetts Institute for Technology (MIT), an expert on artificial intelligence (AI) and robotics, and the host of the Lex Fridman Podcast. We discuss Lex's recent trip to the heart of the Ukrainian-Russian War, geopolitics, perspectives on people living in war zones, the shared human experience, and how information is communicated and controlled. As an experienced podcaster and public educator, Dr. Fridman offers unique insights into the art of holding conversations that grow understanding, especially when they involve people with opposing viewpoints. We also discuss the peer-review process for scientific research publications and how social media and podcasts are evolving the way science and technology are communicated. We consider how to find and follow your life's purpose, maintain ongoing motivation and implement support systems to build and sustain momentum. Our conversation also covers capitalism, masculinity, chess and cheating, Lex's idea for an AI robotics start-up and a Q&A from audience questions solicited on social media. As one of the main inspirations for the Huberman Lab podcast, hosting Dr. Fridman for this special centennial episode was an honor and a pleasure! Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://www.eightsleep.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Dr. Lex Fridman (00:04:30) LMNT, Levels, Eight Sleep (00:08:28) Podcasting (00:12:11) Ukraine, Russia, War & Geopolitics (00:23:17) Conflict & Generalized Hate (00:26:23) Typical Day in Ukraine; American Military & Information Wars (00:37:28) AG1 (Athletic Greens) (00:38:42) Deliberate Cold Exposure & Sauna; Fertility (00:46:44) Ukraine: Science, Infrastructure & Military; Zelensky (00:53:33) Firearms; Violence & Sensitization (00:57:40) MIT & Artificial Intelligence (AI), University Teaching & Pandemic (01:05:51) Publications & Peer Review, Research, Social Media (01:13:05) InsideTracker (01:14:17) Twitter & Social Media Mindset, Andrew Tate & Masculinity (01:26:05) Donald Trump & Anthony Fauci; Ideological Extremes (01:35:11) Biotechnology & Biopharma; Money & Status (01:45:08) Robotics, AI & Social Media; Start-ups (01:53:50) Motivation & Competition; Relationships (02:01:55) Jobs; A Career vs. A Calling; Robotics & Relationships (02:12:11) Chess, Poker & Cheating (02:22:25) Ideas of Lately (02:24:44) Why Lex Wears a Suit & Tie (02:27:50) Is There an AI Equivalent of Psychedelics?  (02:29:06) Hardest Jiu-Jitsu Belt to Achieve (02:32:07) Advice to Young People (02:39:29) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Social Media Disclaimer Title Card Photo Credit: Mike Blabac

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Huberman Lab Podcast Notes Key Takeaways The human brain is shaped differently depending on sounds you are exposed to in utero and throughout the first years of brain developmentIt's probably best to skip the white noise machine to help your babies sleep – our brain is structured to hear environmental noises; constant white noise exposure may lead to delaysWhether you are right-handed or left-handed is strongly genetically determinedThe earlier, more intense, and longer you can have exposure to a second language – the better; human interaction allows for greater specialization of the languageMemory is widely distributed across the brain which is good because even in the event of head injury or illness requiring surgery, memory is generally preservedNew technologies are being studied to give paralyzed and nonverbal patients a chance to communicate again through the use of electrodes connected from the brain to a computer which uses AI to translateRead the full notes @ podcastnotes.orgMy guest is Eddie Chang, MD, a neurosurgeon and professor of neurological surgery at the University of California, San Francisco (UCSF) and the co-director of the Center for Neural Engineering & Prostheses. We discuss the brain mechanisms underlying speech, language learning and comprehension, communicating human emotion with words and hand gestures, bilingualism and language disorders, such as stuttering. Dr. Chang also explains his work developing and applying state-of-the-art technology to decode speech and using that information and artificial intelligence (AI) to successfully restore communication to patients who have suffered paralyzing injuries or “locked in syndrome.” We also discuss his work treating patients with epilepsy. Finally, we consider the future: how modern neuroscience is overturning textbook medical books, the impact of digital technology such as smartphones on language and the future of natural and computer-assisted human communication. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Levels: https://www.levelshealth.com/huberman Eight Sleep: https://www.eightsleep.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Huberman Lab Premium https://hubermanlab.com/premium For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Dr. Eddie Chang, Speech & Language (00:03:00) Levels, Eight Sleep, InsideTracker, Momentous Supplements (00:07:19) Neuroplasticity, Learning of Speech & Environmental Sounds (00:13:10) White Noise Machines, Infant Sleep & Sensitization (00:17:26) Mapping Speech & Language in the Brain (00:24:26) Emotion; Anxiety & Epilepsy (00:30:19) Epilepsy, Medications & Neurosurgery (00:33:01) Ketogenic Diet & Epilepsy (00:34:56) AG1 (Athletic Greens) (00:36:10) Absence Seizures, Nocturnal Seizures & Other Seizure Types (00:41:08) Brain Areas for Speech & Language, Broca's & Wernicke's Areas, New Findings (00:53:23) Lateralization of Speech/Language & Handedness, Strokes (00:59:05) Bilingualism, Shared Language Circuits (01:01:18) Speech vs. Language, Signal Transduction from Ear to Brain (01:12:38) Shaping Breath: Larynx, Vocal Folds & Pharynx; Vocalizations (01:17:37) Mapping Language in the Brain (01:20:26) Plosives & Consonant Clusters; Learning Multiple Languages (01:25:07) Motor Patterns of Speech & Language (01:28:33) Reading & Writing; Dyslexia & Treatments (01:34:47) Evolution of Language (01:37:54) Stroke & Foreign Accent Syndrome (01:40:31) Auditory Memory, Long-Term Motor Memory (01:45:26) Paralysis, ALS, “Locked-In Syndrome” & Brain Computer Interface (BCI) (02:02:14) Neuralink, BCI, Superhuman Skills & Augmentation (02:10:21) Non-Verbal Communication, Facial Expressions, BCI & Avatars (02:17:35) Stutter, Anxiety & Treatment (02:22:55) Tools: Practices for Maintaining Calm Under Extreme Demands (02:31:10) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Huberman Lab Premium, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac Disclaimer

My guest is Eddie Chang, MD, a neurosurgeon and professor of neurological surgery at the University of California, San Francisco (UCSF) and the co-director of the Center for Neural Engineering & Prostheses. We discuss the brain mechanisms underlying speech, language learning and comprehension, communicating human emotion with words and hand gestures, bilingualism and language disorders, such as stuttering. Dr. Chang also explains his work developing and applying state-of-the-art technology to decode speech and using that information and artificial intelligence (AI) to successfully restore communication to patients who have suffered paralyzing injuries or “locked in syndrome.” We also discuss his work treating patients with epilepsy. Finally, we consider the future: how modern neuroscience is overturning textbook medical books, the impact of digital technology such as smartphones on language and the future of natural and computer-assisted human communication. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Levels: https://www.levelshealth.com/huberman Eight Sleep: https://www.eightsleep.com/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Huberman Lab Premium https://hubermanlab.com/premium For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Dr. Eddie Chang, Speech & Language (00:03:00) Levels, Eight Sleep, InsideTracker, Momentous Supplements (00:07:19) Neuroplasticity, Learning of Speech & Environmental Sounds (00:13:10) White Noise Machines, Infant Sleep & Sensitization (00:17:26) Mapping Speech & Language in the Brain (00:24:26) Emotion; Anxiety & Epilepsy (00:30:19) Epilepsy, Medications & Neurosurgery (00:33:01) Ketogenic Diet & Epilepsy (00:34:56) AG1 (Athletic Greens) (00:36:10) Absence Seizures, Nocturnal Seizures & Other Seizure Types (00:41:08) Brain Areas for Speech & Language, Broca's & Wernicke's Areas, New Findings (00:53:23) Lateralization of Speech/Language & Handedness, Strokes (00:59:05) Bilingualism, Shared Language Circuits (01:01:18) Speech vs. Language, Signal Transduction from Ear to Brain (01:12:38) Shaping Breath: Larynx, Vocal Folds & Pharynx; Vocalizations (01:17:37) Mapping Language in the Brain (01:20:26) Plosives & Consonant Clusters; Learning Multiple Languages (01:25:07) Motor Patterns of Speech & Language (01:28:33) Reading & Writing; Dyslexia & Treatments (01:34:47) Evolution of Language (01:37:54) Stroke & Foreign Accent Syndrome (01:40:31) Auditory Memory, Long-Term Motor Memory (01:45:26) Paralysis, ALS, “Locked-In Syndrome” & Brain Computer Interface (BCI) (02:02:14) Neuralink, BCI, Superhuman Skills & Augmentation (02:10:21) Non-Verbal Communication, Facial Expressions, BCI & Avatars (02:17:35) Stutter, Anxiety & Treatment (02:22:55) Tools: Practices for Maintaining Calm Under Extreme Demands (02:31:10) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Huberman Lab Premium, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac Disclaimer

Many users' perceptions and perspectives are shaped by social media across multiple platforms, making it a dominant force in society. British-American Multi-Millarina Andrew Tate took over the algorithm, becoming polarizing among a social media generation that has become progressively sensitized to social media and algorithms.   This week, we break down Andrew Tate's de-platforming and analyze what lessons can be learned while examining how social media companies establish particular agendas and shape how society perceives issues and controversy.  

Intro Hyperplasia is different from hypertrophy in that the adaptive cell change in hypertrophy is an increase in the size of cells, whereas hyperplasia involves an increase in the number of cells. Body Hypertrophy seems to generally lead to hyperplasia Swimming pool analogy Hypertrophy for beginners, intermediate, advanced Common hypertrophy rep ranges Mechanical tension model Pure volume model Periodization changes what works best Sensitization to intensity, volume, etc Not just for bodybuilders Dietary considerations Lean gains vs “bulking” Blood flow restriction training - should we mention Conclusions Periodization!

Huberman Lab Podcast Notes Key Takeaways The inherent goal of the taste system is to get nutrients to survive – attracted to the ones we need, aversion to the ones that may kill usTaste is predetermined: parts of the brain will experience the full behavioral stimulus, even if activated when only ingesting water“I don't believe obesity is a disease of metabolism, I believe obesity is a disease of brain circuits.” – Dr. Charles ZukerSugar molecules activate the “gut-brain axis” which drives the preference for sugarArtificial sweeteners fail to curb the appetite for sugar because they work on the tongue to recognize sweetsness but do not activate sensors in the gut which satisfy the cravingDiseases of malnutrition today are linked to overnutrition (of processed foods), not the actual absence of foodHighly processed foods highjack the gut-brain axis, continuously reinforcing “wanting”Read the full notes @ podcastnotes.orgMy guest this episode is Dr. Charles Zuker, PhD, Professor of Biochemistry, Molecular Biophysics and Neuroscience at Colombia University and an Investigator with the Howard Hughes Medical Institute. Dr. Zuker is the world's leading expert in the biology of taste, thirst and craving. His laboratory explores the mechanisms of taste perception, focusing on how our conscious and unconscious processing of specific foods and nutrients guide our actions and behaviors. We discuss the neural circuits of taste, the “gut-brain axis,” the basis of food cravings and the key difference between wanting (craving) and liking (perceiving) sugar. We also explore how taste perception relates to specific food satiety, thirst, to our emotions, and expectation. We also consider how sugar containing and highly-processed foods can hijack the natural balance of the taste and digestive systems. Dr. Zuker provides a true masterclass in the biology of taste and perception that ought to be of interest to anyone curious about how the brain works, our motivated behaviors and the neural, chemical perceptual aspects of the mind. Thank you to our sponsors Thesis: https://takethesis.com/huberman ROKA: https://roka.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Charles Zuker & Taste Perception (00:03:05) Momentous Supplements (00:04:35) Thesis, ROKA, Helix Sleep (00:08:35) Sensory Detection vs. Sensory Perception (00:11:48) Individual Variations within Perception, Color (00:16:20) Perceptions & Behaviors (00:20:19) The 5 Taste Modalities (00:26:18) Aversive Taste, Bitter Taste (00:28:00) Survival-Based & Evolutionary Reasons for Taste Modalities, Taste vs. Flavor (00:30:14) Additional Taste Modalities: Fat & Metallic Perception (00:34:02) Tongue “Taste Map,” Taste Buds & Taste Receptors  (00:39:34) Burning Your Tongue & Perception (00:42:54) The “Meaning” of Taste Stimuli, Sweet vs. Bitter, Valence (00:51:55) Positive vs. Negative Neuronal Activation & Behavior (00:56:16) Acquired Tastes, Conditioned Taste Aversion  (01:01:44) Olfaction (Smell) vs. Taste, Changing Tastes over One's Lifetime (01:09:14) Integration of Odor & Taste, Influence on Behavior & Emotion (01:17:26) Sensitization to Taste, Internal State Modulation, Salt (01:24:05) Taste & Saliva: The Absence of Taste (01:28:10) Sugar & Reward Pleasure Centers; Gut-Brain Axis, Anticipatory Response (01:36:23) Vagus Nerve (01:43:09) Insatiable Sugar Appetite, Liking vs. Wanting, Gut-Brain Axis (01:52:03) Tool: Sugar vs. Artificial Sweeteners, Curbing Appetite (01:54:06) Cravings & Gut-Brain Axis  (01:57:30) Nutrition, Gut-Brain Axis & Changes in Behavior (02:01:53) Fast vs. Slow Signaling & Reinforcement, Highly Processed Foods  (02:10:38) Favorite Foods: Enjoyment, Sensation & Context (02:15:58) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Huberman Lab Podcast Notes Key Takeaways The inherent goal of the taste system is to get nutrients to survive – attracted to the ones we need, aversion to the ones that may kill usTaste is predetermined: parts of the brain will experience the full behavioral stimulus, even if activated when only ingesting water“I don't believe obesity is a disease of metabolism, I believe obesity is a disease of brain circuits.” – Dr. Charles ZukerSugar molecules activate the “gut-brain axis” which drives the preference for sugarArtificial sweeteners fail to curb the appetite for sugar because they work on the tongue to recognize sweetsness but do not activate sensors in the gut which satisfy the cravingDiseases of malnutrition today are linked to overnutrition (of processed foods), not the actual absence of foodHighly processed foods highjack the gut-brain axis, continuously reinforcing “wanting”Read the full notes @ podcastnotes.orgMy guest this episode is Dr. Charles Zuker, PhD, Professor of Biochemistry, Molecular Biophysics and Neuroscience at Colombia University and an Investigator with the Howard Hughes Medical Institute. Dr. Zuker is the world's leading expert in the biology of taste, thirst and craving. His laboratory explores the mechanisms of taste perception, focusing on how our conscious and unconscious processing of specific foods and nutrients guide our actions and behaviors. We discuss the neural circuits of taste, the “gut-brain axis,” the basis of food cravings and the key difference between wanting (craving) and liking (perceiving) sugar. We also explore how taste perception relates to specific food satiety, thirst, to our emotions, and expectation. We also consider how sugar containing and highly-processed foods can hijack the natural balance of the taste and digestive systems. Dr. Zuker provides a true masterclass in the biology of taste and perception that ought to be of interest to anyone curious about how the brain works, our motivated behaviors and the neural, chemical perceptual aspects of the mind. Thank you to our sponsors Thesis: https://takethesis.com/huberman ROKA: https://roka.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Charles Zuker & Taste Perception (00:03:05) Momentous Supplements (00:04:35) Thesis, ROKA, Helix Sleep (00:08:35) Sensory Detection vs. Sensory Perception (00:11:48) Individual Variations within Perception, Color (00:16:20) Perceptions & Behaviors (00:20:19) The 5 Taste Modalities (00:26:18) Aversive Taste, Bitter Taste (00:28:00) Survival-Based & Evolutionary Reasons for Taste Modalities, Taste vs. Flavor (00:30:14) Additional Taste Modalities: Fat & Metallic Perception (00:34:02) Tongue “Taste Map,” Taste Buds & Taste Receptors  (00:39:34) Burning Your Tongue & Perception (00:42:54) The “Meaning” of Taste Stimuli, Sweet vs. Bitter, Valence (00:51:55) Positive vs. Negative Neuronal Activation & Behavior (00:56:16) Acquired Tastes, Conditioned Taste Aversion  (01:01:44) Olfaction (Smell) vs. Taste, Changing Tastes over One's Lifetime (01:09:14) Integration of Odor & Taste, Influence on Behavior & Emotion (01:17:26) Sensitization to Taste, Internal State Modulation, Salt (01:24:05) Taste & Saliva: The Absence of Taste (01:28:10) Sugar & Reward Pleasure Centers; Gut-Brain Axis, Anticipatory Response (01:36:23) Vagus Nerve (01:43:09) Insatiable Sugar Appetite, Liking vs. Wanting, Gut-Brain Axis (01:52:03) Tool: Sugar vs. Artificial Sweeteners, Curbing Appetite (01:54:06) Cravings & Gut-Brain Axis  (01:57:30) Nutrition, Gut-Brain Axis & Changes in Behavior (02:01:53) Fast vs. Slow Signaling & Reinforcement, Highly Processed Foods  (02:10:38) Favorite Foods: Enjoyment, Sensation & Context (02:15:58) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

My guest this episode is Dr. Charles Zuker, PhD, Professor of Biochemistry, Molecular Biophysics and Neuroscience at Colombia University and an Investigator with the Howard Hughes Medical Institute. Dr. Zuker is the world's leading expert in the biology of taste, thirst and craving. His laboratory explores the mechanisms of taste perception, focusing on how our conscious and unconscious processing of specific foods and nutrients guide our actions and behaviors. We discuss the neural circuits of taste, the “gut-brain axis,” the basis of food cravings and the key difference between wanting (craving) and liking (perceiving) sugar. We also explore how taste perception relates to specific food satiety, thirst, to our emotions, and expectation. We also consider how sugar containing and highly-processed foods can hijack the natural balance of the taste and digestive systems. Dr. Zuker provides a true masterclass in the biology of taste and perception that ought to be of interest to anyone curious about how the brain works, our motivated behaviors and the neural, chemical perceptual aspects of the mind. Thank you to our sponsors Thesis: https://takethesis.com/huberman ROKA: https://roka.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman. For the full show notes, visit hubermanlab.com. Timestamps (00:00:00) Dr. Charles Zuker & Taste Perception (00:03:05) Momentous Supplements (00:04:35) Thesis, ROKA, Helix Sleep (00:08:35) Sensory Detection vs. Sensory Perception (00:11:48) Individual Variations within Perception, Color (00:16:20) Perceptions & Behaviors (00:20:19) The 5 Taste Modalities (00:26:18) Aversive Taste, Bitter Taste (00:28:00) Survival-Based & Evolutionary Reasons for Taste Modalities, Taste vs. Flavor (00:30:14) Additional Taste Modalities: Fat & Metallic Perception (00:34:02) Tongue “Taste Map,” Taste Buds & Taste Receptors  (00:39:34) Burning Your Tongue & Perception (00:42:54) The “Meaning” of Taste Stimuli, Sweet vs. Bitter, Valence (00:51:55) Positive vs. Negative Neuronal Activation & Behavior (00:56:16) Acquired Tastes, Conditioned Taste Aversion  (01:01:44) Olfaction (Smell) vs. Taste, Changing Tastes over One's Lifetime (01:09:14) Integration of Odor & Taste, Influence on Behavior & Emotion (01:17:26) Sensitization to Taste, Internal State Modulation, Salt (01:24:05) Taste & Saliva: The Absence of Taste (01:28:10) Sugar & Reward Pleasure Centers; Gut-Brain Axis, Anticipatory Response (01:36:23) Vagus Nerve (01:43:09) Insatiable Sugar Appetite, Liking vs. Wanting, Gut-Brain Axis (01:52:03) Tool: Sugar vs. Artificial Sweeteners, Curbing Appetite (01:54:06) Cravings & Gut-Brain Axis  (01:57:30) Nutrition, Gut-Brain Axis & Changes in Behavior (02:01:53) Fast vs. Slow Signaling & Reinforcement, Highly Processed Foods  (02:10:38) Favorite Foods: Enjoyment, Sensation & Context (02:15:58) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

I'll talk about the role sensitization plays in training horses. I'll also cover what unconditional and conditional reflexes are. These topics are the beginning of training a horse to respond to different cues, either with R+ or R-.

Join us for the third and final episode of our series on the progress of the Sensitization in Transplantation: Assessment of Risk (STAR) workgroup. Dr. Michelle Hickey joins us to discuss perhaps the newest and most controversial STAR workgroup sub-study, non-HLA antibody testing and diagnostics.

In this episode of RCA Radio, host Brandon Miller is joined by Dr. Matthew Jorgensen and Audrey Turley, Matt a board-certified toxicologist with a Ph.D. in chemistry and is Nelson Laboratory's Chemistry and Materials Scientist and Audrey is a Nelson Labs Senior Biocompatibility Expert.Listen in as Matt and Audrey help educate our listers about Irritation and Sensitization in medical devices biocompatibility for launching your products in this part of the Intro into Biocompatblity podcast series.About RCARegulatory Compliance Associates® (RCA) provides worldwide services to the following industries for resolution of compliance and regulatory challenges:Pharmaceutical Biologic & BiotechnologySterile compoundingMedical deviceWe understand the complexities of running a life science business and possess areas of expertise that include every facet of R&D, operations, regulatory affairs, quality, and manufacturing. We are used to working on the front lines and thriving in the scrutiny of FDA-and globally-regulated companies.As your partners, we can negotiate the potential minefield of regulatory, compliance, quality, and private equity due diligence with insight, hindsight, and the clear advantage of our unique expertise and experience.About Nelson LabsEvery year, hundreds of medical device, pharmaceutical, and tissue companies make Nelson Labs their testing laboratory of choice. For them, the decision is easy. Nelson Labs is a clear leader in the microbiology and analytical chemistry testing industry, offering more than 800 laboratory tests and employing more than 500 scientists and staff in state-of-the-art facilities. We are known for exceptional quality and rigorous testing standards, but it is our focus on the bigger picture that sets us apart. We look beyond test results and partner with you to achieve your long-term business goals — mitigating risk, being first to market, and succeeding with your customers.Companies choose Nelson Labs for our:Thought leaders and approachable experts. We give you direct access to industry authorities who understand your business and add value every step of the way.Customer-centric culture. We take the time to understand your vision. Your goals become our goals.Real-time project management tools and a dedicated client portal. We provide proactive information, keeping you informed and in control.Metric-driven testing processes. We're our own toughest customer, holding ourselves to goals exceeding 99% for things that matter most to you, like quality, turnaround time, and testing accuracy.Global compliance expertise and support. We act as a trusted advisor, helping you navigate the ever-changing compliance landscape.See how we can help you mitigate risk, be first to market, and succeed with your customers.

When it comes to the topic of porn, one of the most common questions is whether or not it can actually be addictive. According to many addiction experts, it absolutely can be.Click here to access the resources discussed in this episode.To learn more about the harms of pornography on consumers, relationships, and its larger societal impacts, visit FTND.org.To support this podcast, click here.As you go about your day we invite you to increase your self-awareness, look both ways, check your blindspots, and consider before consuming.Fight the New Drug collaborates with a variety of qualified organizations and individuals with varying personal beliefs, affiliations, and political persuasions. As FTND is a non-religious and non-legislative organization, the personal beliefs, affiliations, and persuasions of any of our team members or of those we collaborate with do not reflect or impact the mission of Fight the New Drug.

This week, we're back in the flow of the Amidah exploring the 4th and 5th middle weekday blessings. We talk timeless personal Passover stories, S&H green stamps, healing vs cure, and being in the body. There's also lots of inter-text, lots of liturgical variation, and lots of questions to be had. Support us on ko-fi! Membership tiers are now live. There are fun perks to be had! To support the show without perks, you can make a tax-deductible donation here. And please rate, subscribe, and share! It means the world to us, and we are so grateful. Thank you! Be sure to check out this week's Transcript And show notes And follow us on facebook and instagram @thelight.lab

Join us for the second episode of our series on the progress of the Sensitization in Transplantation: Assessment of Risk (STAR) workgroup. During this second episode of the STAR workgroup series we are joined by Dr. David Pinelli for a discussion on alloimmunity and diagnostics.

Drs Russo and Horvath discuss the 2021 Dan Mishell article award winner The concentration of fetal red blood cells in first-trimester pregnant women undergoing uterine aspiration is below the calculated threshold for Rh sensitization by Horvath et al.  

Join us for the first in a multi-episode series on the progress of the Sensitization in Transplantation: Assessment of Risk (STAR) workgroup. In the first episode of the STAR workgroup series, we discuss progress in the utility of anti-HLA antibody testing in clinical trials with Dr. Nicole Valenzuela.

Grandpa Bill in todays asks What different modalities of medicines have you tried for yourself & your pets? Do you or your pet suffer anxiety & depression? Grandpa Bill continues today talking about several different modalities of treatments for both humans and our pets too,, including new developments with #CBDa, #CBGa #,CBD+ more! Sensitization and Tolerance Control Are you an experienced medical cannabis user who requires more and more cannabis to get the same relief? This is a sign of cannabis tolerance. Learn how to overcome your tolerance and become sensitive to cannabis again. Dr. Sulak will help you feel better and save money by reducing your cannabis usage by up to 60%. Feel more and experience superior benefits from cannabis. The free program gives you access to all our step-by-step videos, written content, worksheets and wellness activities. What types of conditions are patients using medical cannabis for? Chronic pain, insomnia, depression & anxiety Post-Traumatic Stress Disorder (PTSD) Cancer, Crohn's Disease & Nausea Multiple Sclerosis (MS), Cancer, seizures, glaucoma & others Start the FREE Program- https://healercbd.com/subscribe-save/?ref=11&campaign=BHSalesKennelKelpHealthyMealBag Dr. Sulak looks forward to sharing his knowledge with you so that you can live and perform your best everyday. Wishing you health and healing.DS Other upcoming events and health topics Holistic Actions, Webinars, Dr.Dustin Sulak and MORE exploring all different modalities for promoting good health in ALL Animals, their People,Plants, and The Planet! via my links at bhsales.vpweb.com We will hear from Dr. Schoen, from The Conscious Animal Lovers Movement (CALM (c)) and his vision of how to harness the healing power of the love of animals globally to help create a healthier, happier, more harmonious world --- Send in a voice message: https://anchor.fm/bhsales/message

The Dr. Junkie show does not offer medical advice. In this episode I take another shot at describing how cocaine works in the body. I talk about where it comes from and how it's produced, why it is so extreme in its effects, and how we can regulate and decriminalize it to put all illegal drug dealers out of business overnight. Plus, I discuss sleep cycles and why they are so important, Sigmund Freud's dark outlook on life and why we can thank cocaine for his conclusions, what happens when we mix cocaine and alcohol.For more on sleep, check out Dr. Matthew Walker's book, Why We Sleep.For more on the history of coca farming, cocaine production, cocaine addiction, and all sorts of other stuff, check out my book, Dr. Junkie: One Man's Story of Addiction and Crime that will Challenge Everything you know about the War on Drugs. The Dr. Junkie Show  was recently listed in Feedspot's top 10 podcasts about drugs.  

In this episode, I take you along on my first experience of injecting heroin. Rituals of use are a big part of addiction. They have increasingly become the focus of both  addiction researchers and treatment providers. When we do something that makes us feel better (take a drug, place a bet, make a move, hit the gas, take a trip, etc.), we begin to feel the effects of that action before we actually do it. And the more we do it, the earlier and more intense our feelings become. Injecting drugs is a ritual of use. We lay out the equipment in a familiar room, on a  familiar table. We turn on the same TV or we click on the same stereo. We notice the same sounds and smells, the same sense of what is coming. All of it becomes part of the ritual.  In cultures of drug prohibition, rituals of use expand to fill an addicted person's entire life. Our laws are designed to make it appear to be the fault of drug users, not the culture which ensured it will happen.  Audio for the intro & outro came from a 1967 anti-drug PSA called Narcotics: Pit of Despair. 

I have recently received so many questions about the book that I thought I would spend an episode talking about it. Dr. Junkie: One Man's Story of Addiction and Crime that will Challenge Everything you Know about the War on Drugs is available on Amazon and Barnes & Nobel. This autobiographical account of addiction and crime in the United States reveals the design-flaws of the current War on Drugs, which has consistently failed to focus on the things citizens should want prioritized, like saving lives, reducing addiction and getting rid of dangerous street drugs. Instead, the we have spent trillions of dollars imprisoning our neighbors, killing our family-members and driving the price of these chemicals sky high. And if we have learned nothing else through the 120 years plus of this worthless war, it is that  people will not be stopped from using drugs, no matter how dangerous, expensive or illegal they are. Dr. Junkie is a story about how we can change our priorities and save lives. We are currently in the midst of the worst overdose crisis in contemporary history, and it can only be stopped with safe supply, therapy, support, treatment...in a word, love.  If we truly want people to stop, and to experience minimal damage from their use, we would legalize all drugs and, as a bonus, put all illegal drug dealers out of business overnight. 

Hello and Welcome everyone to episode #5! Today I am going to talk about another part of pain reprocessing therapy - Emotional Awareness and Expression therapy Let me first briefly summarize the main teaching points of prior 4 episodes  Fibromyalgia pain – neuroplastic pain - misfiring neurons in the brain pain centers and pain pathways. They are misinterpreting safe or neutral signals from the body. THE PAIN IS REAL. The good news is that the pain pathways CAN BE REWIRED and the pain reversed. Other names for neuroplastic pain are central SENSITIZATION or AUGMENTATION pain. Reasons for pain: unprocessed emotions, prior traumatic experiences in life, exacerbated by current trauma or injuries. Winning at fibromyalgia process – my unique method implemented in treatment of my patients with fibromyalgia that borrows from several fields. The principal parts of the process are: Confirm the diagnosis of fibromyalgia (best handled by a Rheumatologist), 2. Education about the neuroplastic pain and Being open to the diagnosis/the concept of neuroplastic pain, and Willingness to Try the methods PRT (pain reprocessing therapy). Of those we talked about A) the practice of fierce self-compassion which combines mindfulness, identifying our emotions and giving ourselves love and compassion like we would do for other people. B) somatic tracking which consists of approaching your pain with curiosity and basically “scanning” your body for all the sensations you feel in the moment and instead of being annoyed or upset, you send safety messages to your brain such as “I am ok, brain, I am healthy and strong, it will be ok”. The purpose of that is to soothe the brain and reassure it like you would reassure a scared small child. Today I will talk about a psychological therapy referred to as emotional awareness and expression therapy (EAET). It is SOMEWHAT new approach but HAS been studied with SUCCESS in patients with fibromyalgia. Some case studies even suggest it can lead to RESOLUTION or REMISSION of the pain in some people! This is why I am so excited about this technique and have started using it in my practice in selected patients in whom I deemed it safe to proceed. We already touched upon how the stress and emotions from the stress, can trigger, worsen or maintain our pain. Focus of EAET is the trauma, stress and relationship problems found in many people with chronic pain. Even more precisely, it focuses on thoughts and feelings. So how does it work? It is done in individual or group sessions, anywhere from 8-12 sessions. After educating my patients about the role of stress and emotions in their pain, we talk about the traumas or conflicts in their lives that appear to drive their pain. Some patients have told me upon initial discussion that they did not have any repressed emotions or no past trauma. As we start talking more, it turns out they have been through so much emotional pain and charged experiences, but they just did not associate them with their physical pain. We talk about it and I ask them to express emotionsthey have been avoiding or blocking related to the trauma or stressors, especially anger, but also guilt, sadness, love and self-compassion. Because EAET is rather new, there are few providers who have been trained specifically to deliver it. Many psychologists and other mental health providers have training in trauma-focused therapies and "exposure-based" therapies that help patients overcome their fears. I am part of the pain reprocessing therapy course led by Dr. Schubiner who is one of the leading minds in the field of chronic pain and utilization of pain reprocessing therapy. He shares with us many successful stories and demonstrations of this techniques in his practice, the success and often immediate improvement is astounding. A Therapist has patients revisit important conflicts or traumatic experiences that involve other people and helps patients "express the unexpressed" feelings to those people. This can be done with writing exercises but also involves "talking to" an empty chair where the imagined other person sits. Patients are encouraged to activate and express their emotions fully, using their words, voice tone, and bodily expression (arms, face). Patients are helped to express the full range of avoided emotionsThey usually go through a range of emotions with guilt following anger, then sadness. Then they are guided by a therapist to love and self-compassion. This is all done with just imagining the other person. Finally, patients are encouraged to plan and role play how they would like to be in real life with people who have been a source of stress or conflict. Such communication depends on the type of relationship and may involve healthy assertiveness and setting boundaries, and often includes being open, vulnerable, and expressing intimacy. Throughout therapy, patients are encouraged to work on emotional awareness, writing exercises, emotional expression, and healthy communication as homework. Successful EAET is typically associated with substantial reductions or even elimination of pain as well as improvements in functioning, mood, and relationships. EAET and related approaches are associated with greater risk than CBT and other psychological treatments for chronic pain. EAET encourages patients to disclose and emotionally express experiences and feelings that may have been avoided for many years and that often are quite upsetting. It is not uncommon, therefore, for patients to become temporarily more upset (e.g., anxious, depressed, angry) as they start to deal with memories and feelings that have long been avoided. Pain and other physical symptoms sometimes increase temporarily. Because patients are encouraged to communicate and interact differently in their relationships, these relationships might change in ways that are unexpected. Practitioners of EAET believe, however, that such emotional and relationship changes are important to make, and even though they may be difficult in the short run, such changes can be healthy and lead to pain reductions in the longer-term. EAET may not be appropriate for certain patients, especially those who have difficulties regulating their emotions, who have trouble thinking when they are emotional, or who tend to hurt themselves or others when memories or feelings are activated or intense. This would be all assessed during early sessions and decisions would be made how to best proceed. That's it for today's session. Please share or leave a review if you found it helpful. I would really appreciate it. In the next episode, we will start tying all of these individual parts I have spoken about so far, together. A Winning at fibromyalgia approach is slowly emerging  Until next time 

Hollywood feeds viewers a lot of problematic stereotypes regarding drug use, perhaps none as misleading as the notorious speedball. Users who combine heroin with a stimulant like methamphetamine or cocaine to create a single injectable liquid are said to be "speedballing," and when it is depicted on television or in books, it is used as the proverbial rock bottom of addiction, the final stop along the train of illogical and uncontrollable drug use. But injectable speedballs are actually pretty uncommon in the drug world. The ways these drugs are prepared and the way the work in the body usually makes combining them a hassle most of us don't bother with; we just shoot them up one-after-the-other.But there are also a lot of reasons why we are tempted to use these drugs together. The chemicals which compose the individual parts of the speedball concoction compliment one another in ways that entice users. They fill the gaps in each other's affects; they both have properties which the other lacks.Check out the research mentioned in this episode here: Kent Berridge & Terry Robinson, "Liking, Wanting & the Sensitization Theory of Addiction."Kent Berridge, "The Debate over Dopamine's Role in Reward: The Case for Incentive Salience." Kent Berridge, "Evolving Concepts of Emotion and Motivation." Maia Szalavitz, Unbroken Brain: A Revolutionary New Way of Understanding Addiction. For Donald Klein's ideas about the Thrill of the hunt/feast, see Peter Kramer, Listening to Prozac

http://nwufortherese.education/2020/07/03/advantages-of-covid-19-for-the-future-with-high-combat-on-covid-19-the-future-seems-promising/ Support this podcast: https://anchor.fm/nwufor/supportSupport this podcast at — https://redcircle.com/education-for-all-and-entertainment/donations

The beauty of democracy lies in a consistent and credible electoral process where the wishes and aspirations of the majority reigns. There are series of activities before the main elections which requires participation of citizens as much as the elections itself. Part of these activities include Continuous Voters Registration (CVR) to update the voters' register and other emerging issues that require attention. The Independent National Electoral Commission (INEC) had earlier announced commencement of the Continuous Voters' Registration across the federation. In a bid to make the process easier, more accessible and user friendly for new and old registrations, the commission had launched a portal which allows a two-step registration process in which first prospective registrants login to pre-register by providing their biodata and some biometrics and second to complete the registration by physically presenting themselves at a designated registration center of their choice. The Commission's Chairman – Prof. Mahmood Yakubu was quoted to have said, “the online innovation was one of the Commission's innovation to enhance voter experience by making the registration exercise faster, easier, and less crowded than before. Given the lingering COVID-19 situation, the new registration solution will help decongest registration centers, reduce delays, and allow prospective registrants to schedule appointments and monitor their applications from the comfort of their homes.” The online registration started on 28th June, 2021 while the physical part of the registration started on 26th July, 2021 across various INEC LGA offices and designated centers. Few days into the physical registration process, various registration centers have witnessed increasing turn out of prospective registrants for the physical capture and other related matters covered by the CVR exercise. On this edition of the programme, we shall be raising awareness on the conducts of the process and issues arising from the various centers as witnessed by prospective registrants. This is with a view to providing relevant updates and information to citizens who wish to participate in the process as a means to strengthening political participation as well as the electoral process (rights to vote) for better outcomes in subsequent election. To do justice to this, we have with us in the studio Mr. Sylvanus Yepe (Head of Voter Education and Publicity – INEC Plateau State) and Engr. Wakili Tol (Head of ICT department INEC Plateau State) Here's the link for new registration https://cvr.inecnigeria.org/Home/start

Kennel Kelp Holistic Healing Hour Hemp for Food ,Clothing, & Shelter Program notes Virtual Mall 50/25-Sensitization and Tolerance Control Are you an experienced medical cannabis user who requires more and more cannabis to get the same relief? This is a sign of cannabis tolerance. Learn how to overcome your tolerance and become sensitive to cannabis again. Dr. Sulak will help you feel better and save money by reducing your cannabis usage by up to 60%. Feel more and experience superior benefits from cannabis. The free program gives you access to all our step-by-step videos, written content, worksheets and wellness activities. What types of conditions are patients using medical cannabis for? Chronic pain, insomnia, depression & anxiety Post-Traumatic Stress Disorder (PTSD) Cancer, Crohn's Disease & Nausea Multiple Sclerosis (MS), Cancer, seizures, glaucoma & others Start the Program --- Send in a voice message: https://anchor.fm/bhsales/message

Question: Why would methylated vitamins increase pain sensitization?I'm not sure. Just to throw out some random threads that may or may not be of use. I think methylation in some people is going to lead to increased synthesis of dopamine. But in general, the effect is going to be to decrease the tonic pool of dopamine. There's going to be some degree to which it decreases other neuro-transmitters. And it's possible that if, particularly, if glycine is not stabilized, that you're going to lose the inhibitory effect of glycine and that you might also lose the effect of ambient glycine in coactivating NMDA receptors. Now off the top of my head, I would think that you would want the glycine there to support.If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

To make police officers behave and act in a gender sensitive manner, Rachakonda police in Telangana is conducting gender sensitization training to newly recruited police constable officers. Rachakonda commissioner of police Mahesh Bhagwat while interacting with the first batch of trainees, said that such training at the very initial stage of they taking up their job would help break stereotypes on gender issues. He said this would help the recruits develop a gender sensitive approach at the workplace as well as when dealing with sexual violence/harassment complaints. The training intends to ensure that the response of the police would be appropriate in situations which warrants them being sensitive. The training will continue regularly for the 1606 police recruits in batches of 50 to 60 twice a week.

In the first part we'll talk about what flooding is and the 2 possible outcomes. In the second part we'll talk about why that's helpful to understand. --- Send in a voice message: https://anchor.fm/creatinggreatgroomingdogs/message

What is addiction? What is dependency? What is the difference?  And what does dopamine have to do with all of this?It turns out that most of what we think we know about addiction is wrong. In this episode I unpack my thoughts (and the current science) on addiction, tolerance, dopamine, sensitization (habituation), and the Learning Disorder model of addiction, which is rapidly replacing the old disease model.

Chromez and Fanatik start by recapping the previous episode that featured Lord Wapi (0:08). They then talk about a video that went viral that showed a woman interrupting a wedding ceremony where her supposed husband was getting married, the irony. This opens a great conversation about the dynamics between Men and Women (1:35). Leader of Zambian opposition political party NDC, Chishimba Kambwili got arrested on Fraud charges, is this the end of him? (41:50). Zambian artist, that doubles as Slapdee's Manager, H-Mac dropped a song called 'Tiliko' that features the late Daev, Slapdee, and Macky 2, the guys dissect who they feel took home the prize for the best verse award (56:39). The guys close off by tackling the now canceled COVID-19 Sensitization rally that was coordinated by the ruling Patriotic Front Party, was this irresponsible? (1:11:30). Follow the hosts; twitter.com/theechromez twitter.com/fanatik_lochead Follow the Podcast; twitter.com/rawconpodcast instagram.com/rawconversationspodcast facebook.com/rawconversationspodcast Join WhatsApp Group; linktr.ee/rawconversationspodcast

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.05.327155v1?rss=1 Authors: Kozlova, A., Butler, R. R., Zhang, S., Ujas, T., Zhang, H., Steidl, S., Sanders, A. R., Pang, Z. P., Vezina, P., Duan, J. Abstract: Rodents are frequently used to model drug addiction, yet their genetic relevance to human addictive behaviors especially the mounting genome-wide association study (GWAS) findings is poorly understood. Considering a possible gateway drug role of nicotine (NIC), we modeled NIC addiction, specifically NIC sensitization (SST) and self-administration (SA), in F1 progeny of inbred Envigo rats (F344/BN) and conducted integrative genomics analyses. We unexpectedly observed male-specific NIC SST and a parental effect of SA only present in paternal F344 crosses. Transcriptional profiling in the ventral tegmental area (VTA) and nucleus accumbens (NAc) core and shell further revealed sex and brain region-specific transcriptomic signatures of SST and SA. We found that genes associated with SST and SA were enriched for those related to synaptic processes, myelin sheath, and tobacco use disorder or chemdependency. Interestingly, SST-associated genes were often downregulated in male VTA but upregulated in female VTA, and strongly enriched for smoking GWAS risk variants, possibly explaining the male-specific SST. For SA, we found widespread region-specific allelic imbalance of expression (AIE), of which genes showing AIE bias towards paternal F344 alleles in NAc core were strongly enriched for SA-associated genes and for GWAS risk variants of smoking initiation, likely contributing to the parental effect of SA. The transcriptional signatures of sex-specific nicotine SST and SA suggest a mechanistic link between genes underlying these processes and human nicotine addiction, providing a resource for understanding the biology underlying the GWAS findings on human smoking and other addictive phenotypes. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.25.312108v1?rss=1 Authors: Li, J., Zain, M., Bonin, R. P. Abstract: Common approaches to studying chronic pain in pre-clinical animal models paradoxically involve measuring reflexive withdrawal responses that are more indicative of acute nociceptive pain. These methods typically do not capture the ongoing nature of chronic pain nor report on behavioral changes associated with pain. In addition, data collection and analysis protocols are often labour-intensive and require direct investigator interactions, potentially introducing bias. In this study, we develop and characterize a low-cost, easily assembled behavioral assay that yields self-reported temperature preference from mice which is sensitive to peripheral sensitization protocols. This system uses a partially automated and freely available analysis pipeline to streamline the data collection process and enable objective analysis. We found that after intraplantar administration of the TrpV1 agonist, capsaicin, mice preferred to stay in cooler temperatures than control injected mice. We further observed that gabapentin, a non-opioid analgesic commonly prescribed to treat chronic pain, reversed this aversion to higher temperatures. We further observed that optogenetic activation of the central terminals of TrpV1+ primary afferents via in vivo spinal light delivery did not induce a similar change in thermal preference, indicating a role for peripheral nociceptor activity in the modulation of temperature preference. We conclude that this easily produced and robust sensory assay provides an alternative approach to investigate the contribution of central and peripheral mechanisms to pathological sensory processing that does not rely on reflexive responses evoked by noxious stimuli. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.01.275099v1?rss=1 Authors: de Clauser, L., Luiz, A. P., Santana-Varela, S., Wood, J. N., Sikandar, S. Abstract: Cancer-induced bone pain (CIBP) is a complex condition comprising components of inflammatory and neuropathic processes, but changes in the physiological response profiles of bone-innervating afferents remain poorly understood. We used a combination of retrograde labelling and in vivo calcium imaging of bone marrow-innervating DRG neurons to determine the contribution of these cells in the establishment and maintenance of CIBP. We found a majority of femoral bone afferent cell bodies in L3 DRG that also express the sodium channel subtype Nav1.8 - a marker of nociceptive neurons - and lack expression of parvalbumin - a marker for proprioceptive primary afferents. Surprisingly, the response properties of bone marrow afferents to both increased intraosseous pressure and acid were unchanged by the presence of cancer. On the other hand, we found increased excitability and polymodality of cutaneous afferents innervating the ipsilateral paw in cancer bearing animals, as well as a behavioral phenotype that suggests changes at the level of the DRG contribute to secondary hypersensitivity. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.253534v1?rss=1 Authors: Zhang, D., Zhao, W., Liu, J., Ou, M., Liang, P., Li, J., Chen, Y., Liao, D., Bai, S., Shen, J., Chen, X., Huang, H., Zhou, C. Abstract: Neuropathic pain affects up to 10% of the total population and no specific target is ideal for therapeutic need. The sodium leak channel (NALCN), a voltage-independent cation channel, mediates the background Na+ leak conductance and controls neuronal excitability and rhythmic behaviors. Here, we show that increases of NALCN expression and function in dorsal root ganglion (DRG) and dorsal spinal cord contribute to chronic constriction injury (CCI)-induced neuropathic pain in rodents. NALCN current and neuronal excitability in acutely isolated DRG neurons and spinal cord slices of rats were increased after CCI which were decreased to normal levels by NALCN-siRNA. Accordingly, pain-related symptoms were significantly alleviated by NALCN-siRNA-mediated NALCN knockdown and completely reversed by NALCN-shRNA-mediated NALCN knockdown in rats or by conditional NALCN knockout in mice. Our results indicate that increases in NALCN expression and function contribute to CCI-induced neuronal sensitization; therefore, NALCN may be a novel therapeutic target for neuropathic pain. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.02.184754v1?rss=1 Authors: Jiang, S. Z., Sweat, S., Dahlke, S., Loane, K., Drossel, G., Xu, W., Tejeda, H. A., Gerfen, C. R., Eiden, L. E. Abstract: Elucidation of the underlying mechanism of dopamine signaling to ERK that underlies plasticity in dopamine D1 receptor expressing neurons leading to acquired cocaine preference is incomplete. NCS-Rapgef2 is a novel cAMP effector, expressed in neuronal and endocrine cells in adult mammals, that is required for D1 dopamine receptor-dependent ERK phosphorylation in mouse brain. In this report, we studied the effects of abrogating NCS-Rapgef2 expression on cAMP-dependent ERK to Egr-1/Zif268 signaling in cultured neuroendocrine cells; in D1 medium spiny neurons (MSNs) of nucleus accumbens slices; and in mouse brain in a region-specific manner. NCS-Rapgef2 gene deletion in the nucleus accumbens (NAc) in adult mice, using AAV-mediated expression of cre recombinase, eliminated cocaine-induced ERK phosphorylation and Egr-1/Zif268 upregulation in D1-MSNs and cocaine-induced behaviors including locomotor sensitization and conditioned place preference (CPP). Abrogation of NCS-Rapgef2 gene expression in medium prefrontal cortex and basolateral amygdala, by crossing mice bearing a floxed Rapgef2 allele with a cre mouse line driven by calcium/calmodulin-dependent kinase IIalpha promoter also eliminated cocaine-induced phospho-ERK activation and Egr-1/Zif268 induction, but without effect on the cocaine-induced behaviors. Our results indicate that NCS-Rapgef2 signaling to ERK in dopamine D1-receptor expressing neurons in the NAc, but not in corticolimbic areas, contributes to cocaine-induced locomotor sensitization and CPP. Ablation of cocaine-dependent ERK activation by elimination of NCS-Rapgef2 occurred with no effect on phosphorylation of CREB in D1 dopaminoceptive neurons of NAc. This study reveals a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations, mediated through NCS-Rapgef2/phospho-ERK activation, independently of PKA/CREB signaling. Copy rights belong to original authors. Visit the link for more info

Dr Linda Bluestein, is a board-certified anesthesiologist and integrative medicine physician with a focus on hypermobility, Ehler-Danlos Syndromes and complex patients with chronic pain. In this brilliant exposition, she defines hypermobility, lays out the esoteric classifications of hypermobile Ehler Danlos Syndrome vs Hypermobility Spectrum Disorders and why naming matters for assessment and treatment of symptoms. Dr Bluestein then dives into practical recommendations for thinking about how connective tissue dysfunction (it's said "If you can’t connect the issues, think connective tissues”) can impact a variety of systems like the gut (constipation, prolapse, reflux, distention, gastroparesis), skin (delayed wound healing, poor scarification), dysautonomia, mast cell activation syndrome, in addition to the typical musculoskeletal conditions of dislocations, subluxations and other joint injuries. She notes, so wisely, that if we can shorten the typical diagnosis from ~25 years to, pretty much anything shorter than that, we can prevent a tremendous amount of chronic pain later in life. And then Dr Bluestein teases apart types of pain: nociceptive (meaning direct injury to tissues like from an injury), neuropathic pain (meaning dysfunction of the nerves themselves) or nociplastic pain (meaning dysfunction in how we process sensation) and the eventual progression to central sensitization syndromes, like fibromyalgia, if pain is allowed to linger. Finally, we cap off with a discussion about some selective pharmaceuticals, some common and some uncommon, and how to think about them: opioids, benzodiazepines, muscle relaxants, oxytocin, NMDA antagonists (magnesium, ketamine, memantine). Find out more: http://www.hypermobilitymd.com/ Book: Disjointed | Navigating the Diagnosis and Management of hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders which can be ordered here: https://www.amazon.com/Disjointed-Navigating-hypermobile-Ehlers-Danlos-Hypermobility/dp/1734794909/ref=pd_lpo_14_t_0/136-4762933-2366558?_encoding=UTF8&pd_rd_i=1734794909&pd_rd_r=acaa36c6-0aac-47c7-a2f3-4bd1b7ba15d7&pd_rd_w=fy7Ld&pd_rd_wg=HsWpW&pf_rd_p=7b36d496-f366-4631-94d3-61b87b52511b&pf_rd_r=RC3MY8A7KJ999FZDE4JY&psc=1&refRID=RC3MY8A7KJ999FZDE4JY

This week Luke goes solo with Tony Montgomery Jr. Get out the pen and paper its time to takes some notes. Let us know if you like these 1 on 1 interviews.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.20.105684v1?rss=1 Authors: Liu, C., Lan, C., Li, K., Zhou, F., Yao, S., Xu, L., Yang, N., Yang, J., Yong, X., Ma, Y., Scheele, D., Kendrick, K. M., Becker, B. Abstract: Overarching conceptualizations propose that the complex social-emotional effects of oxytocin (OXT) in humans are partly mediated by interactions with other neurotransmitter systems. Recent animal models suggest that the anxiolytic effects of OXT are critically mediated by the serotonin (5-HT) system, yet direct evidence in humans is lacking. To determine the role of 5-HT in OXT-induced attenuation of amygdala threat reactivity and sensitization/ desensitization, 121 healthy subjects underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD) before the administration of intranasal OXT or the corresponding placebo-control protocols, respectively. Mean and repetition-dependent changes in threat-specific amygdala reactivity towards threatening stimuli (angry faces) as assessed by fMRI served as the primary outcome. No treatment main or interaction effects on amygdala threat reactivity were observed, yet OXT switched bilateral superficial amygdala sensitization to desensitization and this effect was significantly attenuated during decreased central 5HT signaling via pretreatment with ATD. The present findings provide the first evidence for a role of OXT in threat-specific amygdala desensitization in humans and suggest that these effects are critically mediated by the 5-HT system. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.11.089425v1?rss=1 Authors: Chen, W., Marvizon, J. C. G. Abstract: Latent sensitization is a model of chronic pain in which a persistent state of pain hypersensitivity is suppressed by opioid receptors, as evidenced by the ability of opioid antagonists to induce a period of mechanical allodynia. Our objective was to determine if substance P and its neurokinin 1 receptor (NK1R) mediate the maintenance of latent sensitization. Latent sensitization was induced by injecting rats in the hindpaw with complete Freund's adjuvant (CFA), or by spared nerve injury (SNI). When responses to von Frey filaments returned to baseline (day 28), the rats were injected intrathecally with saline or the NK1R antagonist RP67580, followed 15 min later by intrathecal naltrexone. In both pain models, the saline-injected rats developed allodynia for 2 h after naltrexone, but not the RP67580-injected rats. Saline or RP67580 were injected daily for two more days. Five days later (day 35), naltrexone was injected intrathecally. Again, the saline-injected rats, but not the RP67580-injected rats, developed allodynia in response to naltrexone. To determine if there is sustained activation of NK1Rs during latent sensitization, NK1R internalization was measured in lamina I neurons in rats injected in the paw with saline or CFA, and then injected intrathecally with saline or naltrexone on day 28. The rats injected with CFA had a small amount of NK1R internalization that was significantly higher than in the saline-injected rats. Naltrexone increased NK1R internalization in the CFA-injected rats but nor in the saline-injected rats. Therefore, sustained activation of NK1Rs maintains pain hypersensitivity during latent sensitization. Copy rights belong to original authors. Visit the link for more info

On Rubbin' Minds Chidi Okereke chats with Ebuka Obi-Uchendu on the Palliatives available for Nigerians, are they effective? What a possible lockdown extension might mean, and testing numbers in Nigeria #RubbinMinds. Watch Full video on YouTube.

Awareness

We are exploring how to explain central sensitization to patients using pain neuroscience education with physiotherapist, Eva Huysmans. Eva graduated with a Master's Degree in Physiotherapy and is in the middle of her PhD work. She is working on a randomized controlled trial investigating the effect of perioperative pain neuroscience education for patients undergoing surgery for lumbar radiculopathy. To date, Eva has co-authored over twenty peer-reviewed publications and a manual on pain neuroscience education for the clinician. Next to her research activities, she's working as a physiotherapist in the University Hospital in Brussels, where she helps people cope with chronic pain. During this episode, you'll learn how to recognize central sensitization in clinical practice. How do you objectively evaluate central sensitization? Why are people with central sensitization not the only ones who need pain neuroscience education? All about the introduced term, nociplastic pain. Finally, where does pain neuroscience education fit into a treatment program and how should it be delivered? She has created manuals for clinicians to use pain neuroscience education. As part of this episode, she is providing you with a free download of a pain neuroscience education slide deck that you can use with your patients. To download this slide deck for free, all you have to do is text the word, 169DOWNLOAD, to the number, 44222 or IntegrativePainScienceInstitute.com/169Download. Let's learn all about central sensitization with Eva Huysmans.

It’s known that there’s a relationship between post-traumatic stress disorder, or PTSD, and a higher rate of opioid abuse. What isn’t understood, though, is what that relationship is. Does PTSD cause people to turn to opioids in particular among all the potential drugs of abuse, or is there something about opioid use that makes users particularly sensitive to trauma?This is just what Michael Fanselow, professor in the psychology and psychiatry departments at UCLA, and his colleagues investigated for a recent study in the journal Neuropsychopharmacology. See acast.com/privacy for privacy and opt-out information.

As part of the Cultural Understanding and Empowering Women in IT program ( #cueWIT) ; Ms Judith Lockwood a Canadian Entreprenuer speaks about the importance of sensitizing Canadian employers on the plight of professional newcomer women. --- Send in a voice message: https://anchor.fm/newcomerwomenrealities/message

So, let’s talk about Thinking Safety First Your skin soaks up chemicals like a sponge, so you need to be extremely careful about what you put on it. (The same goes for what you put in your body.) Even though essential oils are bioactive compounds, these highly concentrated ingredients can interact with your skin, possibly causing an allergic response or contact dermatitis (also known as sensitization). This is not to scare you away from using essential oils. They are actually at the bottom of the list of chemicals that can cause reactions with overexposure. Believe it or not, it is safer to use essential oils than to plunge into a chlorinated swimming pool! Still, your body is not designed to have these oils slathered on “neat.” Rather, you need to dilute them with what is called a carrier oil. Trust us, friends don’t let friends use essential oils neat. As a general rule of thumb, you will use three drops of essential oils to each tablespoon of carrier oil in topical applications. If you have particularly sensitive skin, you might want to start with half that much essential oils. Carrier oils are fatty extracts, usually cold-pressed from such sources as almonds, olives, and coconuts, that make an excellent medium to disperse the more concentrated essential oil across your skin. Unlike essential oils, carrier oils are nutritive. They also have healing properties of their own, such as being soothing and anti-inflammatory.

Pain Journey ตอนที่ 3 มาเรียนรู้กับอาการปวด การเกิดประสาทรับความรู้สึกปวดมากเกิน , ไวเกิน , นานเกิน จาก Sensitization ____________ ติดตามเรื่องราว สาระ และความรู้ ที่จะทำให้ "ทุกคนมีสุขภาพที่ดี" ได้ทาง Facebook : https://www.facebook.com/wiztechhealth Youtube: https://youtu.be/sJvWgxf-Cns Spotify : https://spoti.fi/2ojY7Uz Podcasts: https://apple.co/31U1P6q

The second of two podcasts tonight, is about how we learn without even realizing it. The Behavior Vortex talks about two different forms of learning, Habituation and Sensitization! Do you guys know the difference between the two? To find out more subscribe to the podcast on Spotify and Apple Podcast by clicking on the links below! If anyone would like to be interviewed I would love for anyone to come on and talk some mental health! https://podcasts.apple.com/us/podcast/behavior-vortex/id1465481640?ign-mpt=uo%3D4 https://square.site/book/2VDJ7GD72SRFG/swoop-radio https://open.spotify.com/show/1IpJObSuV7sWf3USz5M3bu   --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/behavior-vortex/message

There have been several reports of killings in Port Harcourt recently. Men inviting women over to hotels only to murder them. Here is a call on every woman out there to stay safe and because who they trust. If you need to go visit someone for the first time, please tell someone close to you. Stay safe always.

Today's guest is a true gem

With a promising musical career on the horizon, Stefan Weiner could play multiple musical instruments, sing and write songs. Soon after graduating, 22-year-old Stefan began experiencing physical symptoms, which lead to unending pain that left his doctors baffled.  Unfortunately, it got so bad that Stefan had to stop his music.  Doctors couldn't explain his medical mystery until he went to the Mayo Clinic and finally got a diagnosis:  Central Sensitization Syndrome, a condition where he says his brain hardwired his injuries so it kept sending pain signals even though the tissue had healed. Stefan talks about how he's learned to manage his pain. And now he's back to recording music and has a new song coming out next week, called "Barricade," a song he says is about celebrating who you are.   Mentioned in this episode: StefanAlxndr.com Stefan Alexander on Spotify Stefan's latest release:  Barricade If you enjoy the episode, please subscribe for free, rate & review, and share with your friends. Thanks for listening!  If you'd like to see a list of previously mentioned books or products from former episodes, go to our Resources Page! And if you're looking for inspirational books that I've personally read and recommend, go to our Motivational Tools page! Check out more episodes on our website, TheInspireCafe.com! Like us on Facebook here!

♡ SUPPORT THIS PODCAST ♡ In today's episode, Gina discusses fear in the context of the physical nervous system.  Claire Weekes' fear-adrenaline-fear cycle is explored, as well as the understanding of anxiety as a state of over-sensitization.  Gina offers tips and suggestions to help listeners break out of this cycle and prevent it from happening. To learn more go to: http://www.theanxietycoachespodcast.com Join our Group Coaching Full or Mini Membership Program  Learn more about our One-on-One Coaching What is anxiety? Quote: I discovered I always have choices and sometimes it's only a choice of attitude. -Judith M. Knowlton

In this episode Michaela fields questions during one of her popular workshop for couples. Topics include: •Causes of low libido •Balancing the nervous system •How to re-spark a relationship •The mechanics of desire and intimacy •Sensitization training and attentional skill •How to work with existential pain •Getting more bang for your meditation buck •Previous romantic imprints •How childhood patterns affect relationships •Sexual generosity and giving to your partner •Dominance and submission •Martyrdom vs gifting •Am I too masculine? •Neotantric dogma and gender roles •Learning skills and developing as a person ... For instant access courses, events, and teacher training: www.michaelaboehm.com To order Michaela's book "The Wild Woman's Way": https://amzn.to/3FJEBEa Music by Steve James: https://www.guruviking.com/

In this Key Concepts episode, we are looking at the concept of sensitisation, its implications for how students cope with adversity, and how it might inform our efforts to support them. To learn more about the trauma informed positive behaviour support program, please visit www.tipbs.com

Welcome to the Aromatic Wisdom Podcast! In this episode, we continue from AWP Episode 036 on Phototoxicity with a conversation about Sensitization. If you like to use essential oils undiluted directly from the bottle onto the skin, then you really need to hear this episode. Enjoy the podcast! It is my sincere hope that you will feel inspired to explore essential oils deeper after listening and learn what is possible for your health and well-being when you include aromatherapy into your life. In this episode I talk about: What is essential oil irritation What is essential oil sensitization The signs of sensitization Potential sensitizers How to avoid sensitization My own story of sensitization as well as that of a well-known Aromatherapist Show Notes:  NaturesGift.com How to Leave a Podcast Review Where to Leave a Review for the Aromatic Wisdom Podcast (thank you!)  

We’re currently living in a toxic society: culturally, physically, emotionally and mentally. Between the sick care model, the war on masculinity, addiction and unhealthy habits, something has to be done. What is the unholy alliance that has culturally created this mess? How is biology uniting with culture and totally destroying our young men? Why is it so important for us to do regular mental work? On this episode, I am honored and humbled to be joined by Dr. Michael Miletic as we go in-depth with these issues and topics. This is a lifelong pursuit of making ourselves better and making our attachments to the rest of the world better. -Dr. Michael Miletic     Takeaways The sick care model has created a population that is passive in their health. They don't become proactive in taking care of their health and only take action when they are in crisis. Young men have no way to emote. No one understands them, and they turn to social media and video games for validation. People don’t sleep because they take the stress of the day to bed with them. At the start of the show, Dr. Miletic shared his story and how his interest in medicine was inspired by his mother’s illness. He also shared on how he got injured just before going to the Olympics and how he pulled himself out of depression when it happened. We talked about how society’s view of mental health and doing inner work is so flawed. Dr. Miletic shared on what he calls “algorithmic sick care” and all the issues it has caused for us culturally. We also talked about how biology is uniting with culture right now.   We also discussed: Why the incidence of depression in injured athletes and retired athletes is very high The issues with video game and social media addiction, and what parents can do The power of systematizing your mental work For the passive person who doesn’t take responsibility for their emotional, mental and physical health, it’s easy to blame genetics or someone else for everything that isn’t right. Self-aware people understand that they can empower themselves by doing the necessary mental work. It starts with being sensitized to your own feelings, being aware of what you’re feeling, using your emotions as signals that determine decision making and being able to read other people. The same goes for our physical health, as a lot of diseases and illnesses might be genetically predisposed, but they are lit up by the environment— and that is something we can control. When we work on both our minds and our bodies, we stand a chance to combat all the ills in our society.   Guest Bio- Dr. Michael Miletic is a former Olympic athlete, prominent physician, specialist in clinical neuroscience and metabolic medicine who has originated and refined a unique system to reset the chemical balance in the brain and body. This unique system encompasses specialized lab testing, customized clinical evaluation techniques, energy systems stress response, hormone optimization and balancing, micronutrient replacement, immune response, gut health, inflammation determination and treatment, all integrated into a comprehensive assessment of health and performance. Go to https://www.themileticcenter.com/ for more information.

On this episode, host Amber Rana talks to Dr. Akshay, Director of askinsights.com, who provides an insight on the status of gender sensitivity & gender inequality in India. Amber analyses section 377 and its historical context. You can get in touch with Amber at contact@corpuslegal.in Episodes out every Wednesday. You can listen to this show and other awesome shows on the IVM Podcast App on Android: https://goo.gl/tGYdU1 or iOS: https://goo.gl/sZSTU5 You can check out our website at http://www.ivmpodcasts.com/

Gary Wilson's talk, "The Great Porn Experiment" has changed lives of many men and has brought into attention some of the underlying challenges of our modern world. With erectile dysfunction rates skyrocketing in men under age 40, it was about time we started to look at the science and evidence behind these scary numbers. What's fascinating is how there is overlap in various addictive patterns and at Ketogeek we wanted to better understand how the brain works while potentially interpolating the findings into other lifestyle choices and addictive activities. Bio: Gary Wilson is author of Your Brain on Porn: Internet Pornography and the Emerging Science of Addiction and presenter of the popular TEDx talk ‘The Great Porn Experiment,’ which has been viewed more than 9 million times, and translated into 18 languages. He hosts the website ‘Your Brain On Porn’, which was created for those seeking to understand and reverse compulsive porn use: http://yourbrainonporn.com. He taught anatomy and physiology for years and has long been interested in the neurochemistry of addiction, mating and bonding. In 2015 the Society for the Advancement of Sexual Health presented Wilson with its Media Award for outstanding media contributions and public education on pornography addiction. In 2016, Wilson coauthored an academic paper with 7 US Navy doctors entitled, “Is Internet Pornography Causing Sexual Dysfunctions? A Review with Clinical Reports” and another journal article entitled, “Eliminate Chronic Internet Pornography Use to Reveal Its Effects.” Time Stamps: 5:57 – Gary Wilson’s narrative into the world of porn and porn induced sexual  10:17 – How porn rewires your brain’s reward circuitry 12:00 – How do you figure out if you have porn induced erectile dysfunction (PIED) and not performance anxiety? 13:22 – How soon can men expect to recover from PIED? 14:07 – Why do older men recover faster than younger men? 15:25 – What is the youngest known age in boys who suffer from PIED? *Shocking* 16:15 – Can PIED be permanent? 18:20 – How couples and sexual interaction in global societies may be affected by porn use 20:26 – Brain fog, motivation, social anxiety, cognition and emotional behavior effected by porn use. 22:48 – The science and mechanism of the reward system 26:32 – The potential impact of porn on sexual behaviors, aggression and trends in society 30:10 – How porn use may lead to sexual escalation through hyper stimulation 32:14 – Sensitization, cravings and hijacking the ancient mechanism of human survival 36:46 – Can you measure dopamine and how do different addictive activities spike dopamine? 40:49 – Can anyone be hooked onto porn? 43:20 – What is “Addiction”? A comparison of various types of addictions. 50:41 – Philip Zimbardo & The demise of guys. 51:31 – Can ‘anything’ be addictive? 55:02 – Are there benefits of porn and could it be used during dry seasons of no sex? 57:47 – Do women get hooked on porn and what is the female equivalent of porn use? 59:37 – The impact of social media on anxiety, emotional health and depression. 1:01:05 – “Likes” on social media, “Swipes” on Tinder, perpetual feasting and the dopamine system 1:04:24 – How to take a break from porn usage? 1:06:49 – What kind of resources are available if you’re hooked? 1:07:41 – Message to the adolescent boys and girls 1:09:19 – Role of parents and educators in the lives of young boys and girls 1:11:29 – The necessary studies and the power of delaying gratification. 1:15:10 – How do we capture online anecdotes? 1:18:10 – The ripple effects of hijacking the reward system across the society 1:19:47 – “No Fap”, targeting and propaganda 1:23:43 – Final message & plug Plugs:  Website: https://www.yourbrainonporn.com/ Ted Talk: https://www.youtube.com/watch?v=wSF82AwSDiU Twitter: https://twitter.com/YourBrainOnPorn Book: https://www.amazon.com/Your-Brain-Porn-Pornography-Addiction-ebook/dp/B00N2AH8NW Ketogeek has a massive sphere of influence with it's three pillars of 'Educate', 'Empower' and 'Innovate' and we highly recommend signing up to our newsletter to learn everything from our community news to our products to our latest session with world class educators! Sign up by clicking here!

Jefferson Massah from Radio Gbarnga reports on the crucial work of the Act Alliance Liberia Forum who provided Awareness and Sensitization workshops to the communities of Bong county. The workshops aimed at awareness on the spread and prevention of the Ebola Virus and on coping with the stress and trauma of the Ebola survivors and their relatives. Jefferson Massah von Radio Gbarnga berichtet über die Initiative des Act Alliance Liberia Forums, die Bewusstseins- und Sensibilisierungsworkshops in Bong County durchführte. Die Workshops zielten darauf ab, Kenntnis über die Verbreitung des Virus und Vermeidungstrategien zu vermitteln sowie den Ebola-Überlebenden und deren Verwandten bei der Bewältigung von Stress und Trauma zu helfen.

This show is part 1 of my review of the Women’s Health Section Fall Conference weekend with Dr. Lorimer Moseley and Dr. Paul Hodges. In this episode I am highlighting some of the more important points made by Dr. Lorimer Moseley over the weekend. This episode focuses on the input/output feedback loop, the sensitization of […]

Alexander Banks, Ph.D., Harvard Medical School "Modulation of PPAR-gamma and Insulin Sensitization: The Long March Toward Novel Therapeutics" Thursday, April 19 9:00 AM Russ Berrie Pavilion, 6th Floor Conference Room

Background: Sensitization to common ragweed (Ambrosia artemisiifolia) is associated with a variety of risk factors, which are incompletely defined. Our aim was to evaluate the association of a variety of clinical, geographical and demographical variables with ragweed sensitization and also to determine its frequency in southern Bavaria. Methods: In this cross-sectional multicentre study, we enrolled 977 patients with a documented or suspected atopic disease or food allergy. Data were collected on aeroallergen sensitization, age, sex, type and history of allergic disease, place of residence and potential local ragweed exposure. For this last variable, county ragweed cover was taken as a surrogate variable. Relative rates were calculated with multiple additive logistic regression models. Randomly selected patients with ragweed sensitization had a conjunctival provocation test. Results: According to skin prick tests, 190 patients (19.5%) were sensitized to ragweed. The frequency of this finding increased significantly with a rising number of additional sensitizations. Other less important predictors for a ragweed sensitization were male gender, mugwort sensitization, food allergy and a maximum of complaints in September or October. County of residence, extent of local ragweed cover or type of residential area were without relevance. Of 48 sensitized patients, 26 (54.2%) had a positive conjunctival provocation test. Discussion: Patients with multiple sensitizations may be more readily sensitized to a new aeroallergen. Local geographic or environmental conditions are presumably of minor importance for becoming sensitized to ragweed. The frequency of ragweed allergy among sensitized patients might be high. Copyright (C) 2012 S. Karger AG, Basel

Distinguishing Between Habits and Other Forms of Non-Associative Learning In this 4-part podcast, I'll be discussing How to Form a Productive Habit. In this first episode, I'll explain the groundwork for determining how you'll tackle the formation of a new habit.In this 4-part podcast, I'll be discussing how to Form a Productive Habit. In this first episode, I'll explain the groundwork for determining how you'll tackle the formation of a new habit. So, let's get right to it.To make sure we're all speaking using the same understanding of terms, I'm going to define a few key items: habit, automaticity, habituation and sensitization. Then, I'll explain their relationship to forming productive habits.A habit is an automatic response pattern developed by repeating a behavior until it becomes almost or completely unconscious.Automaticity in psychological terms has been described as "unconscious competence" or the ability to do things without occupying the mind with the low-level details required, allowing them to become a habit. Some examples include driving a car, riding a bicycle, music sight-reading while playing the piano, and even speaking.Habituation is the non-associative learning, psychological process, where a person decreases response to a stimulus after repeated exposure. A good example is your clothing. Once dressed, you feel your clothes on your skin but within minutes you no longer actually sense the clothing as your mind attends to more important stimuli.Sensitization is another form of non-associative learning where a person responds because of a progressively increasing level of stimulus. Try rubbing your arm progressively faster until it burns; your response is to pull away because your brain initiates a pain response. It's best to determine when you are forming a habit, whether you need to concern yourself with habituation or sensitization. For example, forming the productive habit of washing the dishes daily may be one part forming the habit and the other part realizing that something in your youth triggered a fear of dishwashing liquid. You'll need to habituate to the dishwashing liquid touching you before you'll ever be able to form the productive habit. And, you may even have a spouse or roommate remind you (with your permission) to perform the habit-in-process until you do it, so that with each reminder, your brain eventually initiates a crescendo-like response to your own commitment to wash the dishes.

The opium poppy, Papaver somniferum L., is the source of both poppy seeds and opium. The commercially available seeds are widely used as ingredients for various kinds of food. IgE-mediated sensitization to poppy seeds is rare, but, if present, clinical symptoms are usually severe. Cross-sensitizations between poppy seeds and other food allergens have been described with sesame, hazelnut, rye grain and kiwi fruit. We report the case of a 17-year-old female with an apparently food-allergic reaction after ingestion of a poppy seed cake. Allergological workup revealed a poppy seed anaphylaxis and led to the identification of a novel cross-sensitization with buckwheat. Copyright (c) 2006 S. Karger AG, Basel.

Sat, 1 Jan 1977 12:00:00 +0100 https://epub.ub.uni-muenchen.de/6956/1/6956.pdf Koszinowski, Ulrich H.; Gerike, Rainer; Ertl, Hildegund