Podcasts about eastern ontario cheo

Maryam Yassin from the University of Ottawa interviews Dr. Anna Jezierski and Dr. Alex MacKenzie. Dr. Jezierski is a research officer at the Department of Translational Biosciences in the Human Health Therapeutics Research Center at the National Research Council of Canada. She is also an adjunct professor for the Department of Biochemistry, Microbiology, and Immunology at the University of Ottawa. In this episode, Dr. Jezierski shares her research on modeling the human blood-brain barrier using induced pluripotent stem cells and the various applications of this model in studying therapeutics for diseases of the central nervous system. We're also joined by Dr. Alex Mackenzie, an attending pediatrician and senior scientist at the Children's Hospital of Eastern Ontario (CHEO). He has served as the CEO and Scientific Director of CHEO Research Institute and is a cross-appointed member of the Faculty of Medicine at the University of Ottawa. Dr. Mackenzie comments on how this model is revolutionizing drug development. Learn more:  https://www.uottawa.ca/faculty-medicine/dr-anna-jezierski https://www.cheoresearch.ca/research/find-a-researcher/alex-mackenzie/0.03 | BEaTS and host introduction.0.26 | Introduction to Dr. Jezierski.1.17 | Introduction to Blood-Brain Barrier (BBB).3.22 | Creating a BBB model using induced pluripotent stem cells is important.7.07 | How tight junctions are replicated effectively.9.20 | Applications of the iPSC-derived BBB model.12.35 | Introduction to Dr. Alex Mackenzie12.51 | Implications of the model on drug discovery and clinical trials.14.54 | Closing remarks.Soundtracks by the Underground Drive. All rights reserved. Listen more https://www.dropbox.com/scl/fo/yrgjajtxzy4j08zj5iptc/AF7HMueoQwogLQMFxHxSHpU?e=1&preview=BEaTS+-+music+only+2.wav&rlkey=epcpj63eohwgi44mnqg7ctoa6&st=bn1v69ik&dl=0Maryam Yassin (Voice), Aysha Aftab (Post-Production), Dalia Zeidan (Content Generation), Jordan Yin (Producer). 

Dr. Bernard Thébaud is a clinician-scientist with a focus on the clinical translation of stem cell-based therapies for lung diseases. Dr. Thébaud is a senior scientist with the Ottawa Hospital Research Institute (OHRI) and Children's Hospital of Eastern Ontario Research Institute (CHEO RI), and a neonatologist with the Children's Hospital of Eastern Ontario (CHEO), where he provides care to critically ill newborns.  In this episode Dr. Thébaud discusses the importance of innovative cell-based or gene therapies to lessen pulmonary hypertension. Learn more about pulmonary hypertension trials at www.phaware.global/clinicaltrials. Follow us on social @phaware Engage for a cure: www.phaware.global/donate  #phaware Share your story: info@phaware.com #phawareMD #phaware

On today's episode we sit down with Dr. Sonny Dhanani, Chief of the Pediatric Intensive Care Unit (PICU) at the Children's Hospital of Eastern Ontario (CHEO). We discuss the approach and management of the critically ill child, with an in-depth discussion on the A-B-Cs. With respect to airway, we chat tips/tricks for airway management, as well as intubation. On the topic of breathing, we chat about bagging and some of the physiological cardio-respiratory concerns of our efforts. We also discuss the causes of arrest and how our interventions may have a role. Lastly, with respect to the sick child, we cover circulation. Fluid resuscitation (physiology/type/volume/medical vs. trauma), IOs, the symptomatic bradycardic patient(pacing, pressors/medications, etc.), and shock are all topics on the table.  From here, we pivot to how death is determined, and how organ donation works.

“What does this person bring or add to our company?” - Heidi Hauver Traditionally, companies talk about cultural fit, and may look for linear, progressive career paths. Today's interview suggests we turn those traditions on their head and look at what people (including ourselves) can ADD to a particular context, vs. how they fit. We also discuss what moving from transactional to transformational looks like in action. My guest is Heidi Hauver who is currently the VP People Experience at Shinydocs, a technology scale up rethinking the way you find, understand, and action your data. Fairly new to her role, she is embracing the question “where do we want to evolve to?” She has won many awards and is an active volunteer in her community. In this episode of Talent Management Truths, you'll discover:

In this episode, we will be welcoming Dr. Maala Bhatt, the Associate Professor of Pediatrics at the University of Ottawa. She is the Research Director for the Division of Emergency Medicine and a pediatric emergency medicine physician at the Children's Hospital of Eastern Ontario (CHEO). She is a member of the Society for Pediatric Sedation. She led the development of the first standardized definitions for procedural sedation and has published the largest emergency department procedural sedation cohort, establishing practices associated with the safest sedation outcomes. Her primary research interest is in the safety of emergencies department procedural sedation. She has published multiple articles and peer review journals on sedation related topics including on fasting before procedural sedation. The first patient case scenario is of an eighteen month old girl scheduled for a brain MRI for a focal seizure which occurred three days ago, and her parents are asking if they have to keep their NPO for so long and whether there is any science behind this practice of fasting before sedation. The second case is one of a seven year old boy with a forearm fracture which requires redaction and casting under procedural sedation. The patient had eaten a peanut butter sandwich an hour before the fall. Join us as we dive into this insightful discussion with Dr. Bhatt on fasting before procedural sedation and how previous fasting guidelines came about, and what is changing about that. Enjoy!Show HighlightsOur understanding of aspiration and its risk factors with respect to the history of fasting guidelines (02:16)The risk for aspiration during procedural sedation (04:52)The aspiration risk for children prior to sedation when drinking clear liquids (05:38)Advantages and disadvantages of prolonged fasting in children with respect to clear liquids (06:51)Current guidelines being followed today in procedural sedation (08:31)The association between pre-procedural fasting duration and the incidence of sedation related adverse outcomes during emergency department sedation of children (10:43)Dr. Bhatt's thoughts on the 2016 study reporting on the association between aspiration and patient and procedure factors (12:26)Changes in practice that may come about from different publications stating that fasting is not a risk factor for aspiration (15:46)Understanding that NPO time on its own is not a predictor for aspiration (17:45)Additional ResourcesAssociation of Preprocedural Fasting With Outcomes of Emergency Department Sedation in Children

On the first episode of the Treebark Podcast Season 4 Julia is joined by Carrie Owen to discuss transitioning to solid foods.Carrie Owen is a an accredited Occupational Therapist, program designer, facilitator, researcher, and lecturer. She is the owner of sweet pea therapy. She coordinated, consults, and developed the feeding clinics at the Children's Hospital of Eastern Ontario (CHEO). Carrie also has many years of experience working as a lactation consultant.For more information check out Carrie on her website https://sweetpeatherapy.com/ or send her an email at info@sweetpeatherapy.comTo learn more about Julia's work check out her website https://www.treehousemedical.ca/If you're interested in Treehouse Medical's work and you would like to receive exclusive monthly updates on our progress, including pre-launch releases and tech insights, fill out the following form and subscribe today https://treehousemedical-1.hubspotpagebuilder.com/stay-connected See acast.com/privacy for privacy and opt-out information.

This podcast is a review of the Canadian Pediatric Society's position statement on postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia in preterm infants.  It was developed by Dr. Amélie Cyr, a pediatric resident at the University of Saskatchewan with Drs. Brigitte Lemyre, Michael Dunn, Bernard Thébaud, the principle authors of the statement. Dr. Brigitte Lemyre is a clinical investigator and an academic neonatologist at the Children's Hospital of Eastern Ontario (CHEO) and at the Ottawa Hospital.  Dr. Michael Dunn is a neonatologist at Sunnybrook Health Science in Toronto and Dr. Bernard Thébaud is a senior scientist with the Ottawa Hospital Research Institute and a neonatologist at CHEO and the Ottawa Hospital.  

For this week's conversation I am joined by Dr. Marie-Ange Janvier. Marie-Ange is a certified clinical engineer that works at the Children's Hospital of Eastern Ontario (CHEO) in Ottawa, Canada. Marie-Ange has been making ripples in the field of biomedical engineering regionally, nationally and internationally. In addition to being a licensed engineer in Ontario and Quebec she is the Chair of the Canadian Board of Examiners for Clinical Engineering, the Chair of the Bilingual Affairs Committee in the Canadian Medical and Biological Engineering Society and the North American Regional Group Representative for the Council of Societies in the International Federation for Medical and Biomedical Engineering which is a Non-Governmental Organization for the United Nations and the World Health Organization. Marie-Ange's skills and experience have uniquely positioned her to follow through on a number of her passions. She is not only passionate about research, teaching and mentorship, but also in facilitating medical equipment donations to her home country of Haiti and other developing nations. www.yolanderobinson.com/episode30

Lianne Castelino of Where Parents Talk speaks to Dr. Mark Tremblay, father of 4, Senior Scientist and Director, Healthy Active Living and Obesity, Research Group, Children's Hospital of Eastern Ontario (CHEO) about what healthy living behaviours parents and children should strive to maintain with or without the COVID-19 coronavirus global pandemic.

Dr. Simpson is a Pediatric Hematologist-Oncologist at the Children's Hospital of Eastern Ontario (CHEO) and an Assistant Professor at the University of Ottawa. She completed medical school at McGill University, Pediatrics residency and Pediatric Hematology/Oncology fellowship at the University of Toronto, and a Master's of Public Health from Johns Hopkins in the United States. Dr. Simpson is currently the Medical Director of the Sickle Cell Program and Interim Director of the Pediatric Hematology/Oncology Fellowship Training Program at CHEO. Her area of research interest centres on improving the outcomes for individuals with Sickle Cell Disease. Show notes available at northernexposurepodcast.ca

Resilience means pushing through when you doubt yourself and feel overwhelmed by the competition. But failure can be a good thing! This my first episode in a soon to be series of non-designer interviews. Sometimes we find parallels to other industries that help us gain perspective in our own. That's exactly why I am interviewing my good friend Stephanie Davenport, Pediatric Emergency Medicine Physician at the Children's Hospital of Eastern Ontario (CHEO) in Ottawa. She is a true inspiration!

Join Dr. Allan Shefrin, a pediatric emergency physician at the Children's Hospital of Eastern Ontario (CHEO) discuss pediatric respiratory illnesses. Detailed show notes can be found on our website: www.criticallevels.ca

Join Dr. Roger Zemek, a pediatric emergency physician at the Children's Hospital of Eastern Ontario (CHEO) and researcher at the CHEO Research Institute discuss pediatric concussion.  Detailed show notes can be found on our website: www.criticallevels.ca

Today, your host Ellen Gardner, Communications and Marketing at HIROC, speaks with Alex Munter, President and CEO of the Children’s Hospital of Eastern Ontario (CHEO).   One of the misconceptions people have about pediatrics, according to CHEO President and CEO Alex Munter, is that people think of it as a service line, similar to oncology or rehabilitation. This is a mistake says Munter, who stresses that being a child is not a diagnosis and that we need a unique, tailored strategy for children’s health. After 11 years on the job and watching the youth and child population continue to grow, Munter is leading the conversation on social media, and among families and staff at CHEO, about the value and necessity of investing in the well-being of children.   Key Takeaways: [2:45] Why it’s important to remember that being a child is not a diagnosis [3:28] Why we need a unique and tailored strategy for child and youth health [5:20] The most important business reasons to invest in the well-being of children [9:22] Where Canada ranks in child well-being and child health [10:39] Alex’s surprising discoveries about the opportunities and limitations of social media [14:53] Why we should make social media companies more accountable [16:00] What keeps Alex inspired on difficult days [18:02] What it’s going to take to get to a place of zero harm in our healthcare institutions [20:06] Why Alex chose to become a member of HIROC’s board [20:55] Why HIROC is one of the gems of our healthcare system [22:28] Why there is far more triumph than tragedy in a children’s hospital [25:48] How technology, video games and social media have transformed the world at large and children’s health in particular [26:45] Who Alex would interview today if he was still running a newspaper   Mentioned in this Episode: CHEO Dr. Wilbert Keon MD Daniel Kahneman   Listen to more interviews with Healthcare Leaders at HIROC.com Follow us on Twitter, and listen on iTunes and Google Play Music. Email us at Communications@HIROC.com.

Dr. Brian Goldman and CHEO's Bernice Wolf talk Hospital Food with host Hugh Kruzel. Dr. Goldman is an emergency physician plus an author, and public speaker. He has a knack for making medicine understandable as well as improving patient awareness of options and opportunities. His "White Coat, Black Art" radio program appears on CBC weekly . He tackles topics that need addressing, and has his finger on the pulse for calls for change in how healthcare is delivered in Ontario and across Canada. It is my belief Dr. Goldman would push legislators, administrators, and us to imagine possibilities and to embrace best practices. Bernice Wolf is "... a registered dietitian and the Director of Food and Marketed Services at the Children’s Hospital of Eastern Ontario (CHEO) in Ottawa. She has worked in healthcare in northern Saskatchewan, community and large acute care facilities in Ontario. Bernice is an innovator in patient, family and customer satisfaction by implementing the first Room Service model in Canada... Bernice has partnered with local food producers and suppliers and is part of the hospital vegetable and herb garden planting and harvesting team."

In this episode Lisa shares the importance of practicing being IN relationship with others and how this can be challenging at times, including in a systemic way when it contradicts your personal and professional intuition and how she eventually finds her way back to the job she loves the most. Lisa is a registered early childhood educator in Ontario, Canada and has been working in the field for over 20 years. She is the mother of 5 and a grandmother of 2. Lisa shares her journey from becoming a young mother who ventured into the world of home daycare as a way to help someone who was struggling to find care for their child. Lisa’s kids enjoyed having another in the home and this grew into a full-fledged home daycare business. While parenting and caregiving Lisa was keen to know and understanding children better. This led to some workshops that taught a style of parenting that not just wasn’t effective but was also not aligned with Lisa’s intuition as a parent and caregiver. This led to the discovery of attachment and relationship, a style of parenting and caregiving that felt more in line with who she was as a person and a professional. Lisa speaks to the flourishing of this teaching in her personal and professional life but also to the tensions or struggles that accompany this. Lisa has worked in various sectors including home daycare, non profit and for profit centre based care and over three years in the education system. She has actively volunteered in different aspects with children and in attachment focused study groups. Her experience working with children is primarily with the age groups 0 to 5 but she has also worked with children up to the age of 12 and has worked with parents in groups/workshops. Lisa has created and been involved with various book clubs, support groups (ADHD) and home schooling and attachment based groups at Children’s Hospital of Eastern Ontario (CHEO) and through the Neufeld Institute. She returned to school for a second time after having her family to work towards her Bachelor of Child and Youth Care degree and is currently in her last year. Show notes: Registered Early Childhood Educators (ECEs) https://www.college-ece.ca/en Attention Deficit Hyperactivity Disorder (ADHD) https://kidshealth.org/en/parents/adhd.html Dr. Gordon Neufeld (Attachment) https://www.youtube.com/watch?v=_oeqnws-2M0 Neufeld Institute https://neufeldinstitute.org/ Darlene Denis-Friske https://darlenedenisfriske.weebly.com/ Lisa’s Home Daycare Facebook Page @Children's Rainbow Village Family Child Care

In this episode Lisa further contextualizes Relationship and the importance of this dynamic with parenting, caregiving and other areas of your life. Lisa is a registered early childhood educator in Ontario, Canada and has been working in the field for over 20 years. She is the mother of 5 and a grandmother of 2. Lisa shares her journey from becoming a young mother who ventured into the world of home daycare as a way to help someone who was struggling to find care for their child. Lisa’s kids enjoyed having another in the home and this grew into a full-fledged home daycare business. While parenting and caregiving Lisa was keen to know and understanding children better. This led to some workshops that taught a style of parenting that not just wasn’t effective but was also not aligned with Lisa’s intuition as a parent and caregiver. This led to the discovery of attachment and relationship, a style of parenting and caregiving that felt more in line with who she was as a person and a professional. Lisa speaks to the flourishing of this teaching in her personal and professional life but also to the tensions or struggles that accompany this. Lisa has worked in various sectors including home daycare, non profit and for profit centre based care and over three years in the education system. She has actively volunteered in different aspects with children and in attachment focused study groups. Her experience working with children is primarily with the age groups 0 to 5 but she has also worked with children up to the age of 12 and has worked with parents in groups/workshops. Lisa has created and been involved with various book clubs, support groups (ADHD) and home schooling and attachment based groups at Children’s Hospital of Eastern Ontario (CHEO) and through the Neufeld Institute. She returned to school for a second time after having her family to work towards her Bachelor of Child and Youth Care degree and is currently in her last year. Show notes: Registered Early Childhood Educators (ECEs) https://www.college-ece.ca/en Attention Deficit Hyperactivity Disorder (ADHD) https://kidshealth.org/en/parents/adhd.html Dr. Gordon Neufeld (Attachment) https://www.youtube.com/watch?v=_oeqnws-2M0 Neufeld Institute https://neufeldinstitute.org/ Darlene Denis-Friske https://darlenedenisfriske.weebly.com/ Lisa’s Home Daycare Facebook Page @Children's Rainbow Village Family Child Care

In this episode Lisa shares with us how she evolved into the world of home day care. Lisa is a registered early childhood educator in Ontario, Canada and has been working in the field for over 20 years. She is the mother of 5 and a grandmother of 2. Lisa shares her journey from becoming a young mother who ventured into the world of home daycare as a way to help someone who was struggling to find care for their child. Lisa’s kids enjoyed having another in the home and this grew into a full-fledged home daycare business. While parenting and caregiving Lisa was keen to know and understanding children better. This led to some workshops that taught a style of parenting that not just wasn’t effective but was also not aligned with Lisa’s intuition as a parent and caregiver. This led to the discovery of attachment and relationship, a style of parenting and caregiving that felt more in line with who she was as a person and a professional. Lisa speaks to the flourishing of this teaching in her personal and professional life but also to the tensions or struggles that accompany this. Lisa has worked in various sectors including home daycare, non profit and for profit centre based care and over three years in the education system. She has actively volunteered in different aspects with children and in attachment focused study groups. Her experience working with children is primarily with the age groups 0 to 5 but she has also worked with children up to the age of 12 and has worked with parents in groups/workshops. Lisa has created and been involved with various book clubs, support groups (ADHD) and home schooling and attachment based groups at Children’s Hospital of Eastern Ontario (CHEO) and through the Neufeld Institute. She returned to school for a second time after having her family to work towards her Bachelor of Child and Youth Care degree and is currently in her last year. Show notes: Registered Early Childhood Educators (ECEs) https://www.college-ece.ca/en Attention Deficit Hyperactivity Disorder (ADHD) https://kidshealth.org/en/parents/adhd.html Dr. Gordon Neufeld (Attachment) https://www.youtube.com/watch?v=_oeqnws-2M0 Neufeld Institute https://neufeldinstitute.org/ Darlene Denis-Friske https://darlenedenisfriske.weebly.com/ Lisa’s Home Daycare Facebook Page @Children's Rainbow Village Family Child Care

In this week’s episode, Kathryn & Elie chat with Dr. Justine Tishinsky from the University of Guelph and Dr. Jean-Phillipe Chaput from the Children’s Hospital of Eastern Ontario (CHEO) about the importance of getting to bed and sleeping! Listen to hear about the newest sleep research and helpful tips for sleeping better!

This interview with my friend Shawn was recorded over Skype, yet we both live in the same city. Imagine that! Schedules be damned, we made it work with no a second to spare before post time. I really appreciate for taking the time to do this and what was maybe going to become a 15-20 min chat turned in to an 1 hour 30 minute assault on your eardrums with everything from early childhood memories, to video gaming, to online video gaming etiquette, to the right way to market a new game, to the real way games are marketed, to a mutually enjoyed band and a first concert meet and great with said band. Also, the Children's Hospital of Eastern Ontario (CHEO) is very close to his heart - hear what he would do for them and for the kids in his own special way if he had the money we dream about. This is Shawn Hannah!   Rick's Wizard Tech Mods https://www.facebook.com/wizard.t.mods/   Procision Exterior   http://procisionexterior.ca/index.html       Younique Cosmetics  https://www.youniqueproducts.com/eeyorefiona/presenter/myparties#.WvBLRugbO00      

Your hosts this week are Lynn Desjardins, Levon Sevunts, Marie-Claude Simard and Carmel Kilkenny.  (Video of show at bottom of page) ListenEN_Interview_2-20180413-WIE20 Humboldt Broncos hockey player Logan Boulet had signed an organ donation card, inspiring other Canadians to do the same in the wake of his death. (Saskatchewan Junior Hockey League) Humboltd, Saskatchewan has been in the national spotlight for the last week, following the tragic accident there. A transport trailer collided with the bus carrying the town's young hockey players, leaving 16 people dead to date, and another 13 severely injured Just a few weeks ago, 21-year old Logan Boulet had signed an organ donation card and talked to his family about why. When it became clear he would not survive the accident, he was placed on life support and several of his organs were retrieved by surgeons. These will help six people who are waiting for transplants. News of this inspired many Canadians to sign up to donate their own organs in the event of death. Several provinces in Canada noted big increases in their registries. Lynn Desjardins spoke with Michael Terner, the program lead for the Canadian Organ Replacement Register at the Canadian Institute for Health Information. Monsanto’s Roundup Ready soybean seeds. (Dan Gill/AP) The US Dept of Justice gave provisional approval to the takeover of bio-tech giant Monsanto by German chemical giant Bayer, this week. Both organizations are already huge multinationals in the global agricultural market. The multi-billion dollar deal now greatly reduces the competition in agricultural chemicals and seeds. Meanwhile two giant fertilizer companies, Potash Corp and Agrium, have merged to form the company, Nutrien. ChinaChem and Syngenta combined in another chemical and bio tech mega merger worth billions of dollars. And Dow and Dupont did the same. Farmers world-wide fear the global agricultural market is now clearly dominated by just three or four huge corporations. This means likely increased costs for fertilzers and disease and pest control chemicals, more genetically modified crops and fewer varieties of crops, and increased costs for consumers. Marc Montgomery spoke to Jan Slomp, vice president of Canada's National Farmers Union, and asked him about their concerns over this latest mega merger. Rohingya refugee children fly improvised kites at the Kutupalong camp near Cox's Bazar, Bangladesh, on December 10, 2017. (Damir Sagolj/Reuters) Dr. Megan Doherty is a pediatrician and palliative care specialist who works at the Children's Hospital of Eastern Ontario (CHEO). She recently returned from a trip to Bangladesh where she and some colleagues visited the Rohingya refugee camps. She was struck by the lack of palliative care. A little 4-year-old girl who was suffering horrible headaches due to eye cancer was one case that really moved her. In an interview this week, Dr Doherty told Levon Sevunts, there was nothing she could do. The little girl died in terrible pain because the clinics in these camps do not have the medicine to treat and manage pain in chronically or terminally ill patients. Now she is trying to raise awareness about this hidden crisis in refugee camps. Dr. Doherty says with so many resources going to save lives, there is little left for those who are beyond saving.  Images of the week window.jQuery || document.write('

Dr. Bernard Thébaud is a clinician-scientist recruited to Ottawa from Edmonton in 2012 to accelerate the translation of stem cell-based therapies for lung diseases. Dr. Thébaud is a senior scientist with the Ottawa Hospital Research Institute (OHRI) and Children's Hospital of Eastern Ontario Research Institute (CHEO RI), and a neonatologist with the Children's Hospital of Eastern Ontario (CHEO), where he provides care to critically ill newborns. In this episode Dr. Thébaud discusses the importance of early detection and novel approaches to pediatric PH research efforts. Learn more about pulmonary hypertension at www.phaware365.global. Never miss an episode with the phaware® podcast app. Follow us @phaware on facebook, twitter, instagram, youtube & linkedin Engage for a cure: www.phaware.global/donate #phaware #phawareMD

This podcast will provide listeners with an overview of physical punishment in children including a comparison to physical abuse, current laws, other countries policies on physical punishment, and recommendations for parents on discipline. This podcast was developed by Michael Schlegelmilch, a medical student at the University of Alberta, Edmonton, Canada in collaboration with the Child and Youth Protection (CYP) team at the Children’s Hospital of Eastern Ontario (CHEO) in Ottawa, Canada including Drs. Torrey Parker, Louise Murray, Alissa Dupuis and Michelle Ward, staff pediatricians in addition to Abby Browne, registered nurse.   Related Content: Podcast: Physical Abuse of Children 

Exploring Healthcare Leadership with Children’s Hospital CEO, Alex Munter. “Investing in the wellbeing of children really is about the success of our whole society.” Twenty years ago Alex was a City Councillor, involved in the move to ban smoking in public places. At the height of this controversial debate, Alex received several death threats, teaching him how to stay resilient and focused on worthy goals. Now, as a the CEO of a major Children’s Hospital, Alex brings these lessons as well as his amazing energy to tackle the growing issue of Childhood Obesity. We discuss the multiple layers that complicate this issue and what is being done to lead our children and society to a healthier, happier future. His vision of our collective future is truly inspiring and worth hearing. “If we can intervene quickly and effectively with teenagers and put them on the path to positive mental health and good coping skills for the challenges and obstacles that they will encounter, we can completely change the trajectory of their lives.” Alex has over 20 years of leadership in health and social services and a strong commitment to helping families and his community. Alex has been CEO of the Children’s Hospital of Eastern Ontario (CHEO) for six years. Last year he also became the CEO of the Ottawa Children's Treatment Centre (OCTC). Alex's priorities include expanding services, improving access and making CHEO/OCTC digital health leaders. Under his guidance, Forbes Magazine named CHEO the best place to work in Canadian Healthcare last year and again in 2017. “One of the great things about working with the team at CHEO is that people here believe and understand why their work matters.” Links: Alex on LinkedIn: linkedin.com/in/amunter Alex on Twitter: @AlexMunterCHEO Children’s Hospital of Eastern Ontario (CHEO): cheo.on.ca Ubiquity Leadership: www.UbiquityLeadership.com

Coming up on Biotechnology Focus Radio : The future of made-in-Canada CAR-T cells looks bright, Roche Canada and Merck each launch their own individual collaborative cancer research initiatives, and using immunotherapies to kill brain cancer Welcome to another episode of Biotechnology Focus Radio. I’m your host Shawn Lawrence, here to give you a rundown of this week’s top stories on the Canadian biotech scene. As you can tell by our teaser intro, cancer research and new initiatives into new therapies to tackle the disease figure prominently in our news headlines this week, and this is not a coincidence as February happens to be National Cancer Prevention Awareness Month. Story 1 On that note, our first story takes us to Ottawa, ON, where a team of researchers at the Children’s Hospital of Eastern Ontario (CHEO) have made a discovery, featured in Nature, center around a promising combination of immunotherapies that are able to deliver a one-two punch to brain cancer tumours in mice.  Led by Dr. Robert Korneluk, distinguished professor at the University of Ottawa and senior scientist at the CHEO Research Institute, the Ottawa reseach team was able to show in mice that a combination of drugs known as SMAC Mimetics and immune checkpoint inhibitors (ICIs) amplifies kill rates of cancer tumour cells in laboratory testing. The research team also discovered a new mechanism by which the combination promotes long-term immunity against glioblastoma tumours. The combination therapy also proved to be highly effective against breast cancer and multiple myeloma. According to Dr. Korneluk, these findings represent a significant evolution in the field of immunotherapy, for the first time showing the synergistic tumour-killing impact of combining SMAC Mimetics with immune checkpoint inhibitors for glioblastoma. As part of this latest project SMAC Mimetics known as LCL161 and Birinapant were combined with ICI antibodies targeting PD-1 and CTLA-4 immune checkpoints. The findings have their roots in research conducted back in 2014, when a team of scientists led by Dr. Korneluk discovered that combining SMAC Mimetics with immune stimulators or live virus therapies had a synergistic or amplified tumour-killing effect that was greater than either agent on its own. Today’s news shows that SMAC Mimetics also have a powerful synergistic effect with ICIs, relatively new drugs that are showing great promise in the clinic. Eric Lacasse, a scientist at the CHEO Research Institute, adds that two drug companies have initiated human clinical trials this year to assess the impact of this combination of SMAC Mimetics and ICIs on patients with a variety of cancers. Although it could be years before any clinical trials begin for adults or children with the deadly brain cancer, glioblastoma, we’re looking forward to seeing how scientific evidence from these experimental treatments adds to our knowledge. It’s an exciting, exploratory field and we hope we’ve hit a home run.” Shawn Beug was the lead author of both the 2014 and 2017 papers, and the research was funded by the Canadian Cancer Society Research Institute, Brain Canada (with financial support from Health Canada through the Canada Brain Research Fund) and the Canadian Institutes of Health Research. In addition, the work was supported by donations to the Ottawa Regional Cancer Foundation, the Kiwanis Medical Foundation and the CHEO Foundation. Story 2 Continuing with the Cancer Research theme, Hoffmann-La Roche Limited (Roche Canada) reports that Toronto’s Princess Margaret Cancer Centre has joined the company's global cancer immunotherapy Centres of Research Excellence (imCORE) Network. The network brings together the world's leading scientific and clinical experts in cancer immunotherapy to collaborate on the investigation and development of promising new treatment approaches for the disease. As part of gaining a better understanding immune biology and cancer, and to ultimately improve treatment options, this includes initiating pre-clinical and clinical research based on the latest scientific discoveries in cancer immunotherapy and to aggregate, as well as share data within the Network to help accelerate research for people living with cancer.  The imCORE Network is comprised of 21 academic centres, inclusive of Princess Margaret Cancer Centre, from nine countries across the globe.   Dr. Lillian Siu, medical oncologist at Princess Margaret Cancer Centre and Site Lead for the imCORE Network explains why the imCORE newtwork is exciting in the follow audio clip. http://stream1.newswire.ca/media/2017/02/14/20170214_C8704_VIDEO_EN_881863.mp4 As a part of a global announcement regarding the launch of the imCORE Network, Roche has also made a commitment to invest up to 100 million Swiss Francs (more than $130 million Canadian dollars) to support basic and clinical research collaborations related to cancer immunotherapy. Story 3 In an exciting public/private partnership, stakeholders in Quebec have launched a new research, development and investment hub to help accelerate the fight against cancer. The hub, called Oncopole is backed by a $15-million investment by Merck that will be administered over three years and overseen by the Fonds de recherche du Québec – Santé (FRQS). Through its model, Oncopole brings together various stakeholders under one flagship hub in oncology. It’s conception was structured with the involvement of more than 50 experts from the scientific community over the past year, who helped to identify its priorities. Recognizing the range of resources and infrastructures currently available as well as the strategic positioning of many researchers in Québec, the Hub will aspire to strengthen the research and innovation ecosystem in the province. Some functions of Oncopole will include enabling the incubation and creation of companies that will capitalize on innovation; and positioning cancer care in Québec among the best in the world in terms of clinical outcome, patient experience and system efficiency. Based on a thorough analysis of the various hosting possibilities identified across Québec, the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal was selected as the establishment which will host the Oncopole’s coordinating offices. Additionally, the FRQS and Merck hope that this initial investment will attract other partners to join the Oncopole and make it a truly collaborative initiative. Story 4     Switching gears to the bioindustrial sector, the Biotechnology Innovation Organization (BIO) announces that registration and housing are now open for the 2017 World Congress on Industrial Biotechnology. The conference, now in its 14th year brings brings together from across the globe business leaders, investors, academics and policymakers in the biofuels, biobased products, renewable chemicals, synthetic biology, food ingredients and biomass sectors. Industrial and environmental biotechnology is at the forefront of the biobased economy, generating good-paying jobs and making cleaner products and processes. This year event will be held July 23-26, 2017 at the Palais des congrès de Montréal in Montréal, Canada. According to Brent Erickson, executive vice president, Industrial and Environmental at BIO, two new tracks-Flavors, Fragrances and Food Ingredients and Agricultural Crop Technologies and Biomass Supply-have been added to this year’s programming, representing the extended value chain of industrial biotechnology. He adds that the decision to bring the World Congress back to Montréal had very much to do with the success of past events, and the local industries continues support of what has grown into the world’s largest industrial biotechnology conference. In 2016, the BIO World Congress on Industrial Biotechnology drew around 907 industry leaders from 529 companies, 32 countries and 31 states, as well as the District of Columbia and hosted a record 1,961 partnering meetings. For more information on the conference visit http://www.bio.org/worldcongress. Story 4 In our final story this week, BioCanRx, and its partners, are investing $11 million to support 16 collaborative research projects in novel therapies to cure cancer. including research aimed at developing Canada’s clinical Chimeric Antigen Receptor modified T cell (CAR-T) manufacturing capabilities. Considered a powerful new tool in the fight against cancer, CAR-T is on the cutting edge of cancer therapeutics, showing promise in paediatric and adult patients with certain blood cancers such as acute lymphoblastic leukemia and lymphoma. While promising, the development of such therapies require sophisticated manufacturing and expertise. Canada currently does have the basic laboratory infrastructure in place, and with this funding could take significant steps towards fully developing the expertise and capacity required to deliver this technology. The BioCanRx investment is going to research projects that will advance several innovative engineered T cell designs, to accelerate delivery of these novel concepts into clinical testing in Canada. Dr. John Bell, Scientific Director, BioCanRx adds his CAR-T manufacturing initiative is unique in that it represents the Canadian academic community recognizing a gap and stepping up to drive Canadian solutions to meet grassroots efforts taking place in the U.S., China and Europe. He discusses CAR-T cell manufacturing in Canada in the following audio provided by BioCanRX: https://biocanrx.com/wp-content/uploads/custom%20images/BioCanRx_Dr_JohnBellCART3.mp4 To help ensure CAR-T cell therapy is brought to patients safely and effectively, BioCanRx is funding a companion Clinical, Social, and Economic Impact project. It will review the existing base of knowledge and involve patient consultation to design a rigorous CAR-T clinical trial protocol ready to implement once the products are ready for a phase 1 clinical trial. Dr. Manoj Lalu, associate scientist, assistant professor, Clinical Epidemiology and Regenerative Medicine Programs, Ottawa Hospital Research Institute, The Ottawa Hospital and Department of Anesthesiology and Pain Medicine, University of Ottawa discusses CAR-T therapy clinical trial design in the following audio clip. https://biocanrx.com/wp-content/uploads/custom%20images/Dr.%20Lalu%20-%20BioCanRx.mp4 To access the full list of the 16 projects funded, be sure to visit https://biocanrx.com/project-dashboards.   Well that wraps up another episode of the Biotechnology Focus Podcast. We hope you enjoyed it. Be sure to let us know what you think, and we’re also always looking for story ideas and suggestions for future shows, and of course we’d love to hear from you as well, simply reach out to us via twitter @biotechfocus, or by email at the following email address  press@promotivemedia.ca. And remember, you can also listen to past episodes online via our podcast portal at www.biotechnologyfocus.ca . For all of us here at Biotechnology Focus, thanks for listening.