Podcasts about charles l

Today we have another Pulm PEEPs Pearls episode about a core critical care topic. Furf and Monty will be giving a high level overview of the use of steroids in sepsis including a review of the relevant literature and recent guidelines, and pragmatic bedside points. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points Why Steroids in Sepsis? Steroids do not treat the infection — antimicrobials are always first and remain the cornerstone. The goal is addressing critical illness–related corticosteroid insufficiency (CIRCI), where cortisol production cannot keep up with the overwhelming inflammatory demand of septic shock. Hydrocortisone helps in two main ways: Blunts the dysregulated inflammatory response — tempers the excessive vasodilation and febrile response that drive harm beyond the infection itself. Restores vascular sensitivity to catecholamines — sepsis downregulates adrenergic receptors; steroids turn that responsiveness back on. Clinical takeaway: The first thing you notice is vasopressor weaning (or a bend in the escalation curve) — not a rapid improvement in fever or white count. Caveat: These trials predate modern sepsis phenotyping. None distinguish hyperinflammatory vs. hypoinflammatory responders — they treat all comers. The Evidence: Four Landmark Trials Every IM resident and critical care fellow will eventually journal-club these four. The most consistent signal across all of them is faster shock reversal and reduced vasopressor use; the mortality question remains unsettled. Trial (Year)NRegimenKey FindingAnnane (2002)~300Hydrocortisone + fludrocortisoneMortality benefit in ACTH non-responders; criticized methodology and messy cortisol-response testing; not cleanly replicated.CORTICUS (2008)~500Hydrocortisone aloneFaster shock reversal but no mortality benefit, regardless of cortisol responsiveness. Raised (later allayed) superinfection concern. Cornerstone for abandoning routine cort-stim testing.ADRENAL (2018)~3,800Hydrocortisone aloneFaster vasopressor weaning; no 90-day mortality benefit.APROCCHSS (2018)~1,200Hydrocortisone + fludrocortisoneMortality benefit at 90 days. Bottom line: Faster shock reversal is consistent. Mortality benefit appears in 2 of 4 trials (both used fludrocortisone) but not the others. A 2026 meta-analysis showed benefit for hydrocortisone + fludrocortisone vs. placebo, but not for hydrocortisone + fludrocortisone vs. hydrocortisone alone — suggesting hydrocortisone drives the main effect. Who Gets Steroids, and When? 2021 Surviving Sepsis: Consider steroids for norepinephrine or epinephrine ≥ 0.25 mcg/kg/min for ≥ 4 hours despite adequate resuscitation — a reasonable bedside trigger. Early 2026 update: Moved away from a specific numeric trigger — consider steroids when a septic patient is not responding well to vasopressors or has escalating requirements. Make a clinical decision. (Quality of evidence: low to moderate.) Go faster than the threshold when: Known/suspected adrenal insufficiency or home steroids, or florid pressor-requiring shock on arrival. A practical escalation sequence: escalating norepinephrine → add vasopressin (per VASST) → then add steroids if requirements keep climbing. Do NOT wait for an ACTH stimulation test. It does not reliably predict who responds and only delays treatment. Sepsis is an elevated-cortisol state but can dissociate ACTH and cortisol, and cortisol-binding globulin is depleted — the test is too messy to guide care. What to Give: The Regimen Standard dose: Hydrocortisone 200 mg/day, typically 50 mg IV Q6H. (Original trials often used continuous infusions, rarely used in the U.S.) Some start with a 100 mg bolus to gain control. Higher dose: If chronically on steroids / adrenally insufficient, consider ~300 mg/day (e.g., 100 mg Q8H). Fludrocortisone: Unsettled. The two mortality-benefit trials added it (50 mcg PO/NG/OG daily), but hydrocortisone already has mineralocorticoid activity and meta-analyses don't show added benefit over hydrocortisone alone. Most clinicians omit it — adding it is reasonable and safe, just be honest about the uncertainty. Duration & Tapering Typical course: ~7 days is most common. Trial practices varied (ADRENAL ~7 days; VANISH used a taper after 6 days; some continue until pressors are off). No taper needed. You do not need to taper for adrenal insufficiency after a short course — just stop. If pressors dramatically rebound, you can restart, but most patients have gained the benefit they'll get by day 7. Pitfalls & Safety Hyperglycemia: Expected and must be managed (monitor closely; insulin drip if needed). No signal for major DKA / severe complications in the trials. Superinfection / fungal infection: The most-quoted concern, but the overall literature does not show a convincing, statistically significant increase. Be disciplined about stopping on schedule. Muscle weakness: Steroids can worsen critical illness myopathy; a short 7-day course likely has limited effect, but be aware. Other: GI bleeding (follow general PPI prophylaxis guidance) and sodium disturbances (watch for hyper-/hyponatremia). Two things we know: (1) steroids shorten duration of vasopressor support, and (2) they are relatively safe in sepsis. Whether they improve mortality — and in whom — remains open. The Five Pulm PEEPs Pearls Mechanism: Steroids restore catecholamine vascular sensitivity and blunt dysregulated inflammation. The clinical target is vasopressor weaning, not infection treatment. Evidence: Faster shock reversal is the most consistent finding. Mortality benefit is seen in 2 of 4 trials but not the others — still controversial. Some patients likely benefit; we don't yet know who. Trigger: A practical 2021 threshold is levo/epi ≥ 0.25 mcg/kg/min for ≥ 4 hours. Newer guidance drops the strict number — make a clinical decision based on poor pressor response or escalation. Dose: Hydrocortisone 200 mg/day (e.g., 50 mg Q6H). Adding fludrocortisone mirrors two trials, but meta-analyses find no benefit over hydrocortisone alone. Safety: Steroids appear safe in sepsis. Monitor and treat hyperglycemia; no marked increase in superinfection. References and Further Reading Annane, Djillali et al. “Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.” JAMA vol. 288,7 (2002): 862-71. doi:10.1001/jama.288.7.862 Sprung, Charles L et al. “Hydrocortisone therapy for patients with septic shock.” The New England journal of medicine vol. 358,2 (2008): 111-24. doi:10.1056/NEJMoa071366 Venkatesh, Balasubramanian et al. “Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 797-808. doi:10.1056/NEJMoa1705835 Annane, Djillali et al. “Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 809-818. doi:10.1056/NEJMoa1705716 Sun, Alin et al. “Correction: Hydrocortisone combined with fludrocortisone for treatment of adults with septic shock: an updated meta-analysis and systematic review.” Frontiers in medicine vol. 13 1811616. 2 Mar. 2026, doi:10.3389/fmed.2026.1811616 Prescott, Hallie C et al. “Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.” Critical care medicine vol. 54,4 (2026): 715-724. doi:10.1097/CCM.0000000000007089

Les références : Fondation Charles Léopold Mayer pour le progrès humain (FPH) Éditions Charles Léopold Mayer Gérer une fichothèque avec le logiciel BDF Soirée de Contribution au Libre le jeudi 11 juin 2026 chaque deuxième jeudi du mois à la FPHVous pouvez mettre un commentaire pour l'épisode. Et même mettre une note sur 5 étoiles si vous le souhaitez. Il est important pour nous d'avoir vos retours car, contrairement par exemple à une conférence, nous n'avons pas un public en face de nous qui peut réagir. Pour mettre un commentaire ou une note, rendez-vous sur la page dédiée à l'épisode.Aidez-nous à mieux vous connaître et améliorer l'émission en répondant à notre questionnaire (en cinq minutes). Vos réponses à ce questionnaire sont très précieuses pour nous. De votre côté, ce questionnaire est une occasion de nous faire des retours. Pour connaître les nouvelles concernant l'émission (annonce des podcasts, des émissions à venir, ainsi que des bonus et des annonces en avant-première) inscrivez-vous à la lettre d'actus.

Invité: Pierre William Johnson. Le thé est la boisson la plus consommée au monde, après lʹeau. Prendre le thé est pour beaucoup dʹentre nous un rituel apaisant. Mais que savons-nous réellement de la culture de cette infusion, des mains qui cueillent ses feuilles aux enjeux de sa production? Quels sont les mécanismes qui ont démocratisé cette boisson? Quelles solutions trouver pour un thé équitable et durable? Tribu accueille Pierre William Johnson, socio-économiste, consultant et auteur. Il signe ce livre, "Thé: lʹenvers de la tasse. Enjeux sociaux et environnementaux de la filière thé", aux éditions Charles Léoplod Mayer.

Dark Kensington had been dead for twenty-five years. It was a fact; everyone knew it. Then suddenly he reappeared, youthful, brilliant, ready to take over the Phoenix, the rebel group that worked to overthrow the tyranny that gripped the settlers on Mars.The Phoenix had been destroyed not once, not twice, but three times! But this time the resurrected Dark had new plans, plans which involved dangerous experiments in mutation and psionics.And now the rebels realized they were in double jeopardy. Not only from the government's desperate hatred of their movement, but also from the growing possibility that the new breed of mutated monsters would get out of hand and bring terrors never before known to man. (Summary from Project Gutenberg text.)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Dark Kensington had been dead for twenty-five years. It was a fact; everyone knew it. Then suddenly he reappeared, youthful, brilliant, ready to take over the Phoenix, the rebel group that worked to overthrow the tyranny that gripped the settlers on Mars.The Phoenix had been destroyed not once, not twice, but three times! But this time the resurrected Dark had new plans, plans which involved dangerous experiments in mutation and psionics.And now the rebels realized they were in double jeopardy. Not only from the government's desperate hatred of their movement, but also from the growing possibility that the new breed of mutated monsters would get out of hand and bring terrors never before known to man. (Summary from Project Gutenberg text.)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Dark Kensington had been dead for twenty-five years. It was a fact; everyone knew it. Then suddenly he reappeared, youthful, brilliant, ready to take over the Phoenix, the rebel group that worked to overthrow the tyranny that gripped the settlers on Mars.The Phoenix had been destroyed not once, not twice, but three times! But this time the resurrected Dark had new plans, plans which involved dangerous experiments in mutation and psionics.And now the rebels realized they were in double jeopardy. Not only from the government's desperate hatred of their movement, but also from the growing possibility that the new breed of mutated monsters would get out of hand and bring terrors never before known to man. (Summary from Project Gutenberg text.)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Dark Kensington had been dead for twenty-five years. It was a fact; everyone knew it. Then suddenly he reappeared, youthful, brilliant, ready to take over the Phoenix, the rebel group that worked to overthrow the tyranny that gripped the settlers on Mars.The Phoenix had been destroyed not once, not twice, but three times! But this time the resurrected Dark had new plans, plans which involved dangerous experiments in mutation and psionics.And now the rebels realized they were in double jeopardy. Not only from the government's desperate hatred of their movement, but also from the growing possibility that the new breed of mutated monsters would get out of hand and bring terrors never before known to man. (Summary from Project Gutenberg text.)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Dark Kensington had been dead for twenty-five years. It was a fact; everyone knew it. Then suddenly he reappeared, youthful, brilliant, ready to take over the Phoenix, the rebel group that worked to overthrow the tyranny that gripped the settlers on Mars.The Phoenix had been destroyed not once, not twice, but three times! But this time the resurrected Dark had new plans, plans which involved dangerous experiments in mutation and psionics.And now the rebels realized they were in double jeopardy. Not only from the government's desperate hatred of their movement, but also from the growing possibility that the new breed of mutated monsters would get out of hand and bring terrors never before known to man. (Summary from Project Gutenberg text.)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Bringing Up Aysha, the Daughter of My Eldercare Years by Charles L Jarrett Bs Mst Jr MD https://www.amazon.com/Bringing-Aysha-Daughter-Eldercare-Years/dp/B0G6NNPJFV Rodemabridgetolearning.com I desire this work to demonstrate that children should be raised by instructions given by God and by parents who speak and demonstrate love to each other and their children, giving them a foundation upon which to build their own marriage and family. Children should have appropriate corrective discipline and not abuse.

In Retrench, Defend, Compete: Securing America's Future Against a Rising China (Cornell UP, 2025), Charles L. Glaser advances a thought-provoking strategy for securing vital US interests in the face of China's rise. Many believe China's ascent will drive it to war with the United States. Yet this is far from inevitable; geography and nuclear weapons should ensure US security. The real danger, Glaser contends, lies in East Asia's territorial disputes, especially over Taiwan. To reduce the risk of war, Glaser makes a bold case for ending US security commitments to Taiwan and carefully calibrating its policies on protecting South China Sea maritime features. The United States should also strengthen its alliances with Japan and South Korea and eliminate unnecessarily provocative nuclear and conventional weapons policies. These measures, Glaser argues, would defuse China's biggest security concerns while preserving America's core strategic interests. Fusing theoretical insights with policy analysis, Retrench, Defend, Compete lays out a distinctive and compelling approach for managing the world's most consequential geopolitical rivalry—before it's too late. Our guest is Professor Charles Glaser, who is a Senior Fellow in the MIT Security Studies Program. His research focuses on international relations theory and international security policy, including U.S. policy toward China, nuclear weapons policy, and U.S. energy security. Our host is Eleonora Mattiacci, an Associate Professor of Political Science at Amherst College. She is the author of "Volatile States in International Politics" (Oxford University Press, 2023). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

In Retrench, Defend, Compete: Securing America's Future Against a Rising China (Cornell UP, 2025), Charles L. Glaser advances a thought-provoking strategy for securing vital US interests in the face of China's rise. Many believe China's ascent will drive it to war with the United States. Yet this is far from inevitable; geography and nuclear weapons should ensure US security. The real danger, Glaser contends, lies in East Asia's territorial disputes, especially over Taiwan. To reduce the risk of war, Glaser makes a bold case for ending US security commitments to Taiwan and carefully calibrating its policies on protecting South China Sea maritime features. The United States should also strengthen its alliances with Japan and South Korea and eliminate unnecessarily provocative nuclear and conventional weapons policies. These measures, Glaser argues, would defuse China's biggest security concerns while preserving America's core strategic interests. Fusing theoretical insights with policy analysis, Retrench, Defend, Compete lays out a distinctive and compelling approach for managing the world's most consequential geopolitical rivalry—before it's too late. Our guest is Professor Charles Glaser, who is a Senior Fellow in the MIT Security Studies Program. His research focuses on international relations theory and international security policy, including U.S. policy toward China, nuclear weapons policy, and U.S. energy security. Our host is Eleonora Mattiacci, an Associate Professor of Political Science at Amherst College. She is the author of "Volatile States in International Politics" (Oxford University Press, 2023). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/world-affairs

In Retrench, Defend, Compete: Securing America's Future Against a Rising China (Cornell UP, 2025), Charles L. Glaser advances a thought-provoking strategy for securing vital US interests in the face of China's rise. Many believe China's ascent will drive it to war with the United States. Yet this is far from inevitable; geography and nuclear weapons should ensure US security. The real danger, Glaser contends, lies in East Asia's territorial disputes, especially over Taiwan. To reduce the risk of war, Glaser makes a bold case for ending US security commitments to Taiwan and carefully calibrating its policies on protecting South China Sea maritime features. The United States should also strengthen its alliances with Japan and South Korea and eliminate unnecessarily provocative nuclear and conventional weapons policies. These measures, Glaser argues, would defuse China's biggest security concerns while preserving America's core strategic interests. Fusing theoretical insights with policy analysis, Retrench, Defend, Compete lays out a distinctive and compelling approach for managing the world's most consequential geopolitical rivalry—before it's too late. Our guest is Professor Charles Glaser, who is a Senior Fellow in the MIT Security Studies Program. His research focuses on international relations theory and international security policy, including U.S. policy toward China, nuclear weapons policy, and U.S. energy security. Our host is Eleonora Mattiacci, an Associate Professor of Political Science at Amherst College. She is the author of "Volatile States in International Politics" (Oxford University Press, 2023). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/chinese-studies

In Retrench, Defend, Compete: Securing America's Future Against a Rising China (Cornell UP, 2025), Charles L. Glaser advances a thought-provoking strategy for securing vital US interests in the face of China's rise. Many believe China's ascent will drive it to war with the United States. Yet this is far from inevitable; geography and nuclear weapons should ensure US security. The real danger, Glaser contends, lies in East Asia's territorial disputes, especially over Taiwan. To reduce the risk of war, Glaser makes a bold case for ending US security commitments to Taiwan and carefully calibrating its policies on protecting South China Sea maritime features. The United States should also strengthen its alliances with Japan and South Korea and eliminate unnecessarily provocative nuclear and conventional weapons policies. These measures, Glaser argues, would defuse China's biggest security concerns while preserving America's core strategic interests. Fusing theoretical insights with policy analysis, Retrench, Defend, Compete lays out a distinctive and compelling approach for managing the world's most consequential geopolitical rivalry—before it's too late. Our guest is Professor Charles Glaser, who is a Senior Fellow in the MIT Security Studies Program. His research focuses on international relations theory and international security policy, including U.S. policy toward China, nuclear weapons policy, and U.S. energy security. Our host is Eleonora Mattiacci, an Associate Professor of Political Science at Amherst College. She is the author of "Volatile States in International Politics" (Oxford University Press, 2023). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/american-studies

In Retrench, Defend, Compete: Securing America's Future Against a Rising China (Cornell UP, 2025), Charles L. Glaser advances a thought-provoking strategy for securing vital US interests in the face of China's rise. Many believe China's ascent will drive it to war with the United States. Yet this is far from inevitable; geography and nuclear weapons should ensure US security. The real danger, Glaser contends, lies in East Asia's territorial disputes, especially over Taiwan. To reduce the risk of war, Glaser makes a bold case for ending US security commitments to Taiwan and carefully calibrating its policies on protecting South China Sea maritime features. The United States should also strengthen its alliances with Japan and South Korea and eliminate unnecessarily provocative nuclear and conventional weapons policies. These measures, Glaser argues, would defuse China's biggest security concerns while preserving America's core strategic interests. Fusing theoretical insights with policy analysis, Retrench, Defend, Compete lays out a distinctive and compelling approach for managing the world's most consequential geopolitical rivalry—before it's too late. Our guest is Professor Charles Glaser, who is a Senior Fellow in the MIT Security Studies Program. His research focuses on international relations theory and international security policy, including U.S. policy toward China, nuclear weapons policy, and U.S. energy security. Our host is Eleonora Mattiacci, an Associate Professor of Political Science at Amherst College. She is the author of "Volatile States in International Politics" (Oxford University Press, 2023). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/national-security

In Retrench, Defend, Compete: Securing America's Future Against a Rising China (Cornell UP, 2025), Charles L. Glaser advances a thought-provoking strategy for securing vital US interests in the face of China's rise. Many believe China's ascent will drive it to war with the United States. Yet this is far from inevitable; geography and nuclear weapons should ensure US security. The real danger, Glaser contends, lies in East Asia's territorial disputes, especially over Taiwan. To reduce the risk of war, Glaser makes a bold case for ending US security commitments to Taiwan and carefully calibrating its policies on protecting South China Sea maritime features. The United States should also strengthen its alliances with Japan and South Korea and eliminate unnecessarily provocative nuclear and conventional weapons policies. These measures, Glaser argues, would defuse China's biggest security concerns while preserving America's core strategic interests. Fusing theoretical insights with policy analysis, Retrench, Defend, Compete lays out a distinctive and compelling approach for managing the world's most consequential geopolitical rivalry—before it's too late. Our guest is Professor Charles Glaser, who is a Senior Fellow in the MIT Security Studies Program. His research focuses on international relations theory and international security policy, including U.S. policy toward China, nuclear weapons policy, and U.S. energy security. Our host is Eleonora Mattiacci, an Associate Professor of Political Science at Amherst College. She is the author of "Volatile States in International Politics" (Oxford University Press, 2023). Learn more about your ad choices. Visit megaphone.fm/adchoices

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Le thé est la deuxième boisson la plus bue au monde après l'eau mais quel est l'envers de la tasse ? Les campagnes de plaidoyer et les politiques internationales ne s'y intéressent pas pourtant ces délicieuses feuilles sont encore produites sur un modèle social et économique hérité du passé colonial ! Avec :  - Pierre-William Johnson, socio-économiste en économie écologique pour son ouvrage Thé, l'envers de la tasse (aux Éditions Charles Léopold Mayer) - François-Xavier Delmas, chercheur de Thé, fondateur du Palais des thés, auteur de Chercheur de thé: De la découverte à l'initiation (aux éditions de la Martinière), et du podcast : Un Thé Un Voyage.     Musiques diffusées dans l'émission ► The Kinks - Have a cup of tea ► Yeko music - Baara.

Le thé est la deuxième boisson la plus bue au monde après l'eau mais quel est l'envers de la tasse ? Les campagnes de plaidoyer et les politiques internationales ne s'y intéressent pas pourtant ces délicieuses feuilles sont encore produites sur un modèle social et économique hérité du passé colonial ! Avec :  - Pierre-William Johnson, socio-économiste en économie écologique pour son ouvrage Thé, l'envers de la tasse (aux Éditions Charles Léopold Mayer) - François-Xavier Delmas, chercheur de Thé, fondateur du Palais des thés, auteur de Chercheur de thé: De la découverte à l'initiation (aux éditions de la Martinière), et du podcast : Un Thé Un Voyage.     Musiques diffusées dans l'émission ► The Kinks - Have a cup of tea ► Yeko music - Baara.

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

When I was growing up in the 1980s and 1990s, Rolling Stone magazine was an indispensable resource for discovering the hip edge of American pop culture. Of course, I didn't realize at the time that the magazine had its roots in the 1960s counterculture, crafted by entrepreneur Jann Wenner as a subversive Trojan horse within the staid landscape of Cold War America. On this episode, historian Charles L. Ponce de Leon joins me for a conversation about his new book Rolling Stone and the Rise of Hip Capitalism: How a Magazine Born in the 1960s Changed America (UNC Press 2026), as we explore the magazine's complex evolution and the ironies of "counterculture" becoming "mainstream." Check out my '90s music podcast/video series with John Lombardo, 120 MONTHS: https://substack.com/@120months Subscribe to Nostalgia Trap to listen to our News Trap freakouts and other bonus content: https://patreon.com/nostalgiatrap   

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Please visit answersincme.com/860/96036801-replay to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, experts in nontuberculous mycobacterial lung disease discuss the latest in diagnosis and optimized management of Mycobacterium avium complex (MAC) lung disease. Upon completion of this activity, participants should be better able to: Describe strategies to assess suspected nontuberculous mycobacterial (NTM) lung disease; Review guideline-recommended treatment plans for Mycobacterium avium complex (MAC) lung disease; Explain the clinical significance of the latest evidence for emerging first-line therapies for MAC lung disease, in the context of current standard of care; and Outline best practices to enhance outcomes for patients with MAC lung disease, including those receiving approved or emerging first-line therapies.

Please visit answersincme.com/860/96036801-replay to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, experts in nontuberculous mycobacterial lung disease discuss the latest in diagnosis and optimized management of Mycobacterium avium complex (MAC) lung disease. Upon completion of this activity, participants should be better able to: Describe strategies to assess suspected nontuberculous mycobacterial (NTM) lung disease; Review guideline-recommended treatment plans for Mycobacterium avium complex (MAC) lung disease; Explain the clinical significance of the latest evidence for emerging first-line therapies for MAC lung disease, in the context of current standard of care; and Outline best practices to enhance outcomes for patients with MAC lung disease, including those receiving approved or emerging first-line therapies.

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Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Listen Ad Free https://www.solgoodmedia.com - Listen to hundreds of audiobooks, thousands of short stories, and ambient sounds all ad free!

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Dr. Harish Kinni, a triple-board-certified emergency medicine and critical care physician and assistant professor at the Mayo Clinic, provides an overview of the fundamentals of ventilator care for emergency department professionals. We will review key modes that we should know, the variables to set, how to adjust them for your patient's needs, and provide troubleshooting tips and tricks for when things suddenly go awry. This is sure to be one of the most helpful chapters of Always on EM, but don't let it take your breath away! CONTACTS X - @AlwaysOnEM; @VenkBellamkonda YouTube - @AlwaysOnEM; @VenkBellamkonda Instagram – @AlwaysOnEM; @Venk_like_vancomycin; @ASFinch Email - AlwaysOnEM@gmail.com REFERENCES & LINKS Swart P, Nijbroek SGLH, Paulus F, Neto AS, Schultz MJ. Sex Differences in Use of Low Tidal Volume Ventilation in COVID-19-Insights From the PRoVENT-COVID Study. Front Med (Lausanne). 2022 Jan 3;8:780005. doi: 10.3389/fmed.2021.780005. PMID: 35300177; PMCID: PMC8923734. McNicholas BA, Madotto F, Pham T, Rezoagli E, Masterson CH, Horie S, Bellani G, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study. Eur Respir J. 2019 Oct 17;54(4):1900609. doi: 10.1183/13993003.00609-2019. PMID: 31346004. Swart P, Deliberato RO, Johnson AEW, Pollard TJ, Bulgarelli L, Pelosi P, de Abreu MG, Schultz MJ, Neto AS. Impact of sex on use of low tidal volume ventilation in invasively ventilated ICU patients-A mediation analysis using two observational cohorts. PLoS One. 2021 Jul 14;16(7):e0253933. doi: 10.1371/journal.pone.0253933. PMID: 34260619; PMCID: PMC8279424. Evans, Laura1; Rhodes, Andrew2; Alhazzani, Waleed3; Antonelli, Massimo4; Coopersmith, Craig M.5; French, Craig6; Machado, Flávia R.7; Mcintyre, Lauralyn8; Ostermann, Marlies9; Prescott, Hallie C.10; Schorr, Christa11; Simpson, Steven12; Wiersinga, W. Joost13; Alshamsi, Fayez14; Angus, Derek C.15; Arabi, Yaseen16; Azevedo, Luciano17; Beale, Richard18; Beilman, Gregory19; Belley-Cote, Emilie20; Burry, Lisa21; Cecconi, Maurizio22; Centofanti, John23; Coz Yataco, Angel24; De Waele, Jan25; Dellinger, R. Phillip26; Doi, Kent27; Du, Bin28; Estenssoro, Elisa29; Ferrer, Ricard30; Gomersall, Charles31; Hodgson, Carol32; Hylander Møller, Morten33; Iwashyna, Theodore34; Jacob, Shevin35; Kleinpell, Ruth36; Klompas, Michael37; Koh, Younsuck38; Kumar, Anand39; Kwizera, Arthur40; Lobo, Suzana41; Masur, Henry42; McGloughlin, Steven43; Mehta, Sangeeta44; Mehta, Yatin45; Mer, Mervyn46; Nunnally, Mark47; Oczkowski, Simon48; Osborn, Tiffany49; Papathanassoglou, Elizabeth50; Perner, Anders51; Puskarich, Michael52; Roberts, Jason53; Schweickert, William54; Seckel, Maureen55; Sevransky, Jonathan56; Sprung, Charles L.57; Welte, Tobias58; Zimmerman, Janice59; Levy, Mitchell60. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Critical Care Medicine 49(11):p e1063-e1143, November 2021. | DOI: 10.1097/CCM.0000000000005337  Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS, Talmor D, Thompson BT, Wunsch H, Uleryk E, Brozek J, Brochard LJ; American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine. An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263. doi: 10.1164/rccm.201703-0548ST. Erratum in: Am J Respir Crit Care Med. 2017 Jun 1;195(11):1540. doi: 10.1164/rccm.19511erratum. PMID: 28459336. Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). Crit Care Med. 2020 Jun;48(6):e440-e469. doi: 10.1097/CCM.0000000000004363. PMID: 32224769; PMCID: PMC7176264. Wang W, Scharfstein D, Wang C, Daniels C, Needham D, Brower R, NHLBI ARDS Clinical Network. Estimating the Causal Effect of Low Tidal Volume Ventilation on Survival in Patients with Acute Lung Injury. J R Stat Soc Ser C Appl Stat. 2011. PMC: PMC3197806 Brower RG, Thompson BT, NIH/NHLBI/ARDSNetwork. Tidal volumes in acute respiratory distress syndrome--one size does not fit all. Crit Care Med. 2006. Hager DN, Krishman JA, Hayden D, Brower RG, ARDSNet NIH / NHLBI. Tidal Volume Reduction in Patients with acute Lung Injury When Plateau Pressures Are Not High. Am J Resp Crit Care Med. 2005. Rubenfeld GD, Cooper C, Carter G, Thompson BT, Hudson LD. Barriers to providing lung protective ventilation to patients with acute lung injury. Crit Care Med. 2004. Chatburn RL, El-Khatib M, Mireles-Cabodevila E. A taxonomy for mechanical ventilation: 10 fundamental maxims. Respir Care. 2014 Nov;59(11):1747-63. doi: 10.4187/respcare.03057. Epub 2014 Aug 12. PMID: 25118309. Guo L, Wang W, Zhao N, Guo L, Chi C, Hou W, Wu A, Tong H, Wang Y, Wang C, Li E. Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis. Crit Care. 2016 Jul 22;20(1):226. doi: 10.1186/s13054-016-1396-0. PMID: 27448995; PMCID: PMC4957383. Rice TW, Wheeler AP, Bernard GR, Hayden DL, Schoenfeld DA, Ware LB, NIH NHLBI ARDS Network. Comparison of the Sp02/FI02 Ratio and the PaO 2/FI02 in Patients with Acute Lung Injury or ARDS. Chest. 2007. Zhang G, Burla MJ, Caesar BB, Falank CR, Kyros P, Zucco VC, Strumilowska A, Cullinane DC, Sheppard FR. Emergency Department SpO2/FiO2 Ratios Correlate with Mechanical Ventilation and Intensive Care Unit Requirements in COVID-19 Patients. West J Emerg Med. 2024 May;25(3):325-331. doi: 10.5811/westjem.17975. PMID: 38801037; PMCID: PMC11112664.   WANT TO WORK AT MAYO? EM Physicians: https://jobs.mayoclinic.org/emergencymedicine EM NP PAs: https://jobs.mayoclinic.org/em-nppa-jobs   Nursing/Techs/PAC: https://jobs.mayoclinic.org/Nursing-Emergency-Medicine EMTs/Paramedics: https://jobs.mayoclinic.org/ambulanceservice All groups above combined into one link: https://jobs.mayoclinic.org/EM-Jobs

Listen Ad Free https://www.solgoodmedia.com - Listen to hundreds of audiobooks, thousands of short stories, and ambient sounds all ad free!

Listen Ad Free https://www.solgoodmedia.com - Listen to hundreds of audiobooks, thousands of short stories, and ambient sounds all ad free!

When a drunken guard leaves a woman stranded in a sleazy saloon on Ganymede, she finds an unlikely protector in a quiet, man whose strange cowardice may hide a deadly secretIf you have a story you'd like to contribute to the series, you can visit https://submissions.soundconceptmedia.com/You can support the show by becoming a paid subscriber on Substack: https://auditoryanthology.substack.comBy becoming a paid subscriber you can listen to every episode completely ad-free!Curator: Keith Conrad linktr.ee/keithrconradNarrator: Darren Marlar https://darrenmarlar.com/Other shows hosted by Darren:Weird Darkness: https://weirddarkness.com/Paranormality Magazine: https://weirddarkness.tiny.us/paranormalitymagMicro Terrors: Scary Stories for Kids: https://weirddarkness.tiny.us/microterrorsRetro Radio – Old Time Radio In The Dark: https://weirddarkness.tiny.us/retroradioChurch of the Undead: https://weirddarkness.tiny.us/churchoftheundead Hosted on Acast. See acast.com/privacy for more information.

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Immerse yourself in captivating science fiction short stories, delivered daily! Explore futuristic worlds, time travel, alien encounters, and mind-bending adventures. Perfect for sci-fi lovers looking for a quick and engaging listen each day.

Amid the chaos of World War II, a secret project emerged from the depths of military innovation—Project X-Ray. It was an idea so strange, so deceptively simple, it bordered on madness: an army of bats, each carrying a hidden firestorm. Under the cover of night, they would infiltrate enemy cities, vanishing into eaves and rafters—silent and unseen. Without warning, flames would erupt from the shadows, consuming everything in their wake. Designed to spread fear as much as fire, the plan was as terrifying as it was eccentric and most would have been excused for believing it could surely never work. But then, if necessity was the mother of invention, bravery was surely the mother of success, and as the world found out in 1945, the war effort needed something bold.  SOURCES Couffer, Jack (1992) Bat Bomb: World War II's Other Secret Weapon. University of Texas Press, TX, USA. Alperovitz, Gar (1995) The Decision to use the Atomic Bomb. Harper Collins, London, UK. Ham, Paul (2011) Hiroshima Nagasaki. Harper Collins, London, UK. McNichols, Charles L and Carus, Clayton D. (1942) One Way to Cripple Japan: The Inflammable Cities of Osaka Bay. Harper's, June 1942, pp. 29-36. NY, USA. Trimble, William F. & Lewis, David (1988) Lytle S. Adams, the Apostle of Nonstop Airmail Pickup. Technology and Culture, Vol. 29, No. 2 (Apr., 1988), pp. 247-265. The Johns Hopkins University Press, USA. ------- For almost anything, head over to the podcasts hub at darkhistories.com Support the show by using our link when you sign up to Audible: http://audibletrial.com/darkhistories or visit our Patreon for bonus episodes and Early Access: https://www.patreon.com/darkhistories The Dark Histories books are available to buy here: http://author.to/darkhistories Dark Histories merch is available here: https://bit.ly/3GChjk9 Connect with us on Facebook: http://facebook.com/darkhistoriespodcast Or find us on Twitter: http://twitter.com/darkhistories & Instagram: https://www.instagram.com/dark_histories/ Or you can contact us directly via email at contact@darkhistories.com or join our Discord community: https://discord.gg/cmGcBFf The Dark Histories Butterfly was drawn by Courtney, who you can find on Instagram @bewildereye Music was recorded by me © Ben Cutmore 2017 Other Outro music was Paul Whiteman & his orchestra with Mildred Bailey - All of me (1931). It's out of copyright now, but if you're interested, that was that. Learn more about your ad choices. Visit megaphone.fm/adchoices

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Email:cdona@aol.com Listen to us live on mytuner-radio, onlineradiobox, fmradiofree.com and streema.com (the simpleradio app)https://onlineradiobox.com/search?cs=us.pbnnetwork1&q=podcast%20business%20news%20network&c=ushttps://mytuner-radio.com/search/?q=business+news+networkhttps://www.fmradiofree.com/search?q=professional+podcast+networkhttps://streema.com/radios/search/?q=podcast+business+news+network

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BachelorClues and PaceCase dive into all the latest happenings across the Bachelor franchise. Joan Vassos celebrates a major milestone, joining the 100K club on Instagram, while Charles L. captures fans' attention with his first TikTok post – sparking speculation about his potential as the next Golden Bachelor. The hosts discuss the surprising drop in ratings for the Golden Bachelorette's Fantasy Suites episode and what this could mean for the show's future. Plus, they recap the top parasocial plays of the week and share insider updates on upcoming finales and watch parties. Join Clues and PaceCase as they analyze the big moments and hidden nuances in Bachelor Nation!__Join the Pit on Patreon for more exclusive content and shows! : / gameofroses__SHOP: https://www.gameofroses.co/shop10% off code: GOR2024code valid through 9/8/24__Want coaching tips? email gameofrozes@gmail.com__Follow us on TikTok: @gameofrosesFollow us on Instagram-Game of Roses: @gameofrosespodPacecase: @pacecaseBachelor Clues: @bachelorclues Hosted on Acast. See acast.com/privacy for more information.

BachelorClues and PaceCase dive into a recap of The Golden Bachelorette, season 1, episode 8, where the men gather for a special "Men Tell All" event. As they analyze the episode, they discuss the surprising emotional moments, particularly the bond between contestants Mark and Jonathan, highlighted by a touching exchange of post-it notes that moved everyone to tears. They examine the lack of typical Bachelor drama and explore how the show instead focused on the camaraderie and brotherhood among the men. The hosts also share their insights on why Charles L. might be a frontrunner for the next Golden Bachelor, bringing depth and humor to their breakdown of the evening's best (and most unusual) moments, including a BBQ segment, a fan chant for "Golden Mansion Men," and the ongoing “Burger Gate” debate.__Join the Pit on Patreon for more exclusive content and shows! : / gameofroses__SHOP: https://www.gameofroses.co/shop10% off code: GOR2024code valid through 9/8/24__Want coaching tips? email gameofrozes@gmail.com__Follow us on TikTok: @gameofrosesFollow us on Instagram-Game of Roses: @gameofrosespodPacecase: @pacecaseBachelor Clues: @bachelorclues Hosted on Acast. See acast.com/privacy for more information.

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Today Your Mom and Dad are breaking down all their thoughts on this very musical episode of Joan Golden Bachelorette season! They chat about Kim's masterpiece, Pascal getting the most Pascal 1-on-1 ever, sponsored kickball games and injuries, Charles L continuing to be the best, Jonathan's vulnerability, Joan's talk with the men, the return of GGT, and much more! ***Join Your Mom and Dad on Tuesday (10/8) for the first recap of the new Love is Blind season (ep 1-6)  THANKS TO OUR SPONSORS: ***SMALLS: Head to https://www.Smalls.com/MOMDAD and use promo code MOMDAD at checkout for 50% off your first order PLUS free shipping! ***CUDDLY: Head to https://www.cuddly.com/MOMDAD and help make a difference! ***VIONIC SHOES: Use code MOMDAD at checkout for 15% off your entire order at https://www.vionicshoes.com 

In an unforgettable episode, the Mansion Men take a trip to the pharmacy in hopes of addressing their density-caused sleeplessness, Charles L. knocks in the game-winning run in front of dozens of adoring fans, and Pascal swallows his pride and smiles through a ride on a used private jet. Thanks for listening. (Timestamps below)Text the mailbag: (773) 234-7794SocialInstagram @rosecastpodcastTwitter/X @rosecastpodcastTikTok @rosecastpodcastFacebook group facebook.com/groups/rosecastnationMerch store: rimandab.comTimestamps (approximate):0:15 Not getting caught up in the moment2:45 Merch announcement4:00 Snoring, tossing, turning, other things6:00 Pascal 1-1 date - day time10:00 Back at the house12:00 Back on the date14:00 Charles L. and Guy17:00 Pascal 1-1 date - night time20:00 Back at the house21:00 Back on the date23:00 Group date - day time29:00 Group date - after party36:00 Jonathan 1-1 date - day time39:00 Kim and the Mansion Men41:00 Jonathan 1-1 date - evening time46:00 Cocktail Party55:00 Rose Ceremony58:00 Mailbag1:09:00 AB's ‘Bachelor' Headline of the Week: 'Golden Bachelorette': Dan made last out in kickball. Is he 'out' for good? (spoilers) (Naples Daily News)1:10:00 Power Rankings Hosted on Acast. See acast.com/privacy for more information.

Who showed up at the mansion?! This week on the show, Jared, Kay, and Jaz break down episode 3, which was "Chock" full of feels. After a Vegas adventure, a very precarious KickBowl, and some unexpected family drama, Joan must confront her past in more ways than one. But what we really want to know is...is Charles L getting a spinoff, already? Follow along for more on @alwayson on IG! Learn more about your ad choices. Visit megaphone.fm/adchoices

BachelorClues and PaceCase break down all the latest happenings in Bachelor Nation, including Joan Vassos' surprising struggle with ratings on The Golden Bachelorette, despite her impressive social media gains. The hosts dive into a heated discussion about whether Bachelor in Paradise should take inspiration from Love Island to improve its format and appeal. They also shine a spotlight on Charles L's unexpected rise in popularity, speculating on what could be fueling his success. With updates on upcoming live watch parties, behind-the-scenes stories, and all the latest parasocial plays, this episode keeps you up to date on everything happening in the world of The Bachelor.__Join the Pit on Patreon for more exclusive content and shows! : / gameofroses__SHOP: https://www.gameofroses.co/shop10% off code: GOR2024code valid through 9/8/24__Want coaching tips? email gameofrozes@gmail.com__Follow us on TikTok: @gameofrosesFollow us on Instagram-Game of Roses: @gameofrosespodPacecase: @pacecaseBachelor Clues: @bachelorclues Hosted on Acast. See acast.com/privacy for more information.

We're getting into the (BBQ) meat of this season's Golden Bachelorette, and Kay, Jared, and Jaz are cannonballing right in. Listen as the three gush over Charles L, go full Mickey Mouse, chat Gil controversy, and try to remember that French guy's name. Plus, your hosts share their own prom night stories. Follow along for more on @alwayson on IG! Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

Charles L got sober in 1945, he is celebrating his 50th AA Anniversary at this meeting hosted by the The Conway Group in May of 1995. 5 new events added to the event list, including the 28th Annual Thailand AA Roundup. Its not until March 2025 so you have plenty of time to plan a trip, registration opens in a few weeks. Details: https://scast.us/thairu Coming up this weekend is the Northwest Fellowship of the Spirit Event in Stanwood Wa. Details: https://scast.us/nwfots Full Event List: https://scast.us/event Support Sober Cast: https://sobercast.com/donate Email: sobercast@gmail.com Roundup, retreat, convention or workshop coming up? List the event on the Sober Cast website. Visit the link above and look for "Submit Your Event" in the blue box. Sober Cast has 2600+ episodes available, visit SoberCast.com to access all the episodes where you can easily find topics or specific speakers using tags or search. https://sobercast.com