Podcast appearances and mentions of Jenny Lin

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Best podcasts about Jenny Lin

Latest podcast episodes about Jenny Lin

The Piano Pod
Season 5 Episode 18: "Bach Reimagined - Artistic Innovation of Timeless Music for All Audiences" feat. Eleonor Bindman - Pianist, Arranger, & Recording Artist

The Piano Pod

Play Episode Listen Later May 20, 2025 105:11 Transcription Available


In this inspiring episode of The Piano Pod, "Bach Reimagined - Artistic Innovation of Timeless Music for All Audiences," Eleonor Bindman - pianist, arranger, and recording artist - joins us for an intimate conversation about her groundbreaking work reimagining the music of J.S. Bach for solo and four-hand piano.From her bestselling Brandenburg Duets with Jenny Lin to her most recent solo project ABSOLUTE—featuring beautifully idiomatic piano transcriptions of Bach's Lute Suites—Eleonor's artistry invites musicians and listeners of all levels to discover the joy, depth, and brilliance of Bach.In this episode, we talk about:Why she believes “there is no one way to play Bach”Her transcription philosophy and creative processAdvocating for accessible classical music—without compromising qualityHow piano duets can foster collaboration, joy, and musicianship at every stageTips for navigating polyphony, articulation, pedaling, and ornamentation in Bach's keyboard worksHer Stepping Stones to Bach series and empowering adult amateurs and young students alikeLegacy, innovation, and what it means to be a 21st-century artist-educator

The Piano Pod
Official Trailer ✅: "Bach Reimagined - Artistic Innovation of Timeless Music for ALL Audiences" feat. Eleonor Bindman

The Piano Pod

Play Episode Listen Later May 19, 2025 2:48 Transcription Available


“It became vital to me to focus on a new way of looking at Bach's music…” — Eleonor BindmanHere is the trailer for the upcoming episode of The Piano Pod

Tales From A Costume Designer
JENNY LIN - Makeup Department Head

Tales From A Costume Designer

Play Episode Listen Later Feb 23, 2024 85:02


This week, Whitney is so excited to be hosting one of her previous collaborators on the show, the talented Makeup Department Head Jenny Lin! We talk about transforming Jennifer Coolidge into the “West Bay Medium” for We Have A Ghost, her amazing times she's spent working with Robert Rodriguez, creating a safe space in her trailer, working with the costume department, staying organized during filming and continuity work, protecting her time during “lasts looks”, as well as fabulous advice for those trying to break into the industry.  --- Makeup Department Head Jenny Lin Credits include: We Have A Ghost | Tell Me Lies | Queen of the South | Alita: Battle Angel | Hypnotic | Spy Kids: Armageddon | Not Dead Yet --- Jenny is a science nerd who fell into makeup accidentally while in college at UT Austin. The very act of creating sparked something in herself to explore and led to working hands-on at a cosmetics company part time while pursuing her undergrad. Her first unexpected opportunity arose when Jenny was approached fill in super last minute makeup on her first short film, but the catch was that she'd have to basically work nonstop for five days straight… at the end of that very sleepless week, something ignited within her and Jenny has not looked back ever since.   Fast forward a decade, Jenny's makeups have been seen on major motion pictures, television shows and national commercials. Beyond her video work, Jenny attained experience in makeup for commercial print ads and lifestyle shoots as well as a roster of faces for red carpet, special events and celebrity weddings and her clientele includes hometown Austin cult movie director Robert Rodriguez.   Jenny's truest passion is in designing and executing imaginative makeups for her directors while collaborating with all the actor, and all creative departments to get the job done beautifully, efficiently and as cost efficient as possible. Skills range in special effect and trauma makeups, airbrushing, tattoo and facial hair work on top of corrective, beauty and character makeups.   --- Jenny Lin Links: Website: makeupbyjennylin.com Instagram: @makeupbyjlin --- TFACD Links: Patreon: Tales From A Costume Designer Instagram: @talesfromacostumedesigner Twitter: @talesfromaCD TikTok: @talesfromaCD --- Whitney Anne Adams Links: Website: whitneyadams.com Instagram: @WAACostumeDesign Twitter: @WhitneyAAdams TikTok: @waacostumedesign --- Pay Equity Links: Pay Equity Now IG: @payequitynow Pay Equity Now TikTok: @payequitynow Costume Designers Guild IG: @cdglocal892 Local USA 829 Pay Equity Task Force IG: @usa829payequity United Scenic Artists Local 829 IG: @unitedscenicartists

Asian American Stories Los Angeles- AAPI LA
Another Beautiful Country with Jenny Lin, Vivian Wenli Lin, and Charlene Liu

Asian American Stories Los Angeles- AAPI LA

Play Episode Listen Later Feb 9, 2024 31:02


Another Beautiful Country is an exhibition that draws its name from the Chinese translation of America (美國/měiguó) and the common term, American-born Chinese, or ABC.  The exhibit features many local AAPI artists and presents their experiences. Through their works, the artists present transnational relations, familial dynamics, and intimate tales of migration.  Those featured in this episode are the exhibit's curator, Jenny Lin, Vivian Wenli Lin, and Charlene Liu. 

Talkhouse Podcast
Panda Bear (Animal Collective) with Paul Maroon (The Walkmen)

Talkhouse Podcast

Play Episode Listen Later Aug 24, 2023 44:01


On this week's Talkhouse Podcast we've got two guys who were part of monumentally influential bands in the 2000s, and who continue to make groundbreaking music today: Paul Maroon and Noah Lennox.  Maroon is behind the incredible, instantly recognizable guitar sound of The Walkmen, a band that sort of split up a decade ago but reunited just this year for what has turned into an incredibly jubilant tour. The band is currently in Europe, where they just played a show in Lennox's adopted home country of Portugal, and they'll return for a string of U.S. dates this fall, culminating in a hometown—that'd be New York—show in October. Since the Walkmen split, Maroon has mostly turned his attention to composing classical music and the occasional film score. He put out a really engaging record with the pianist Jenny Lin called 13 Short Piano Pieces, with each of those pieces inspired by and named for a different place Maroon has lived—he currently calls Seville, Spain home. Check out “El Raval” right here, and go to Paulmaroon.co for info on his solo stuff, or thewalkmen.com for tour dates. Maroon released a seven-inch recently that featured singing from his friend Noah Lennox, who's perhaps better known by the name he uses as part of Animal Collective, Panda Bear. Lennox has been part of that massively influential experimental rock band for nearly 25 years, and he's released a ton of great music both with Animal Collective and as a solo artist. His latest release, though, is a collaboration with Pete Kember, also known as Sonic Boom. Kember was a member of Spacemen 3 way back when, and he's also released incredible music as Spectrum and E.A.R. He's also earned his production stripes over the years, producing records for Beach House, MGMT, and… Panda Bear. Last year, Kember and Lennox released a collaborative album they recorded during the pandemic called Reset, and they just followed it with a dub version of the album remixed by Adrian Sherwood called Reset in Dub. Check out “Gettin' to the Point” from Reset. In this conversation, we learn that Lennox was in attendance for the first-ever Walkmen show; we hear about their adventures living in Portugal and Spain, the difference between a good show and a bad show, and whether these two are “daily guys.” Lennox also makes an accurate prediction about the NBA Finals, even though, as you'll hear, this is not a basketball podcast. Enjoy. Thanks for listening to the Talkhouse Podcast, and thanks to Noah Lennox and Paul Maroon for chatting. If you liked what you heard, please follow us on your favorite podcasting platform, and check out all the goodness at Talkhouse.com. This episode was produced by Myron Kaplan, and the Talkhouse theme is composed and performed by the Range. See you next time!

Voices for Justice
Jenny Lin

Voices for Justice

Play Episode Listen Later Mar 25, 2023 48:29


Tuesday, May 27, 1994, is just two days after Jenny Lin's 14th birthday. She comes home from school to an empty house in Castro Valley, California. Like a lot of kids, both of her parents work, and Jenny is expected to get her chores and homework done before they get home. But also, like a lot of kids, especially a lot of teenagers, Jenny decides that before she gets to work on those tasks, she will talk to some friends on the phone. Jenny's last call ends just after 5 pm. About 30 minutes later, her father, John Lin, calls home to check on her, but there's no answer. He doesn't immediately panic; Jenny is a very responsible kid, and she's used to this routine. She's probably just doing something and didn't hear the phone.   Around 7 pm, John walks into a quiet house. He doesn't see Jenny anywhere. But it's clear that Jenny had been there. The back door is unlocked, the TV is on, and Jenny's microwave dinner is sitting on the kitchen counter. After John doesn't see Jenny on the first floor of the house, he then walks upstairs and notices that the bathroom door in his room is closed.   When he opens the door, the scene John walks into is inconceivable. Jenny is lying face down, covered in blood. Nearly 30 years later, the case is still unsolved, and the Lin family and investigators struggle to make sense of why Jenny was targeted.   If you have any information about her case, please contact the Alameda County Sheriff's Office at 510-667-3636. For more information about the Jenny Lin foundation, visit https://jennylinfoundation.org/ Thank you to our sponsor ZocDoc. Go to Zocdoc.com/Justice and download the Zocdoc app for free. Then find and book a top-rated doctor today. Many are available within 24 hours. For more information about the podcast and the cases discussed, visit VoicesforJusticePodcast.com   Don't forget to follow me on social media under Voices for Justice Podcast & SarahETurney   Join the Patreon family to get instant access to a library of extra content, support the show, and support these cases https://www.patreon.com/VoicesforJustice   Voices for Justice is a podcast that uses adult language and discusses sensitive and potentially triggering topics including violence, abuse, and murder. This podcast may not be appropriate for younger audiences. All parties are innocent until proven guilty in a court of law. Some names have been changed or omitted per their request or for safety purposes. Listener discretion is advised.   The introduction music used in Voices for Justice is Thread of Clouds by Blue Dot Sessions. Outro music is Melancholic Ending by Soft and Furious. The track used for ad transitions is Pinky by Blue Dot Sessions. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Murder Diaries
MURDERED: Jenny Lin

The Murder Diaries

Play Episode Listen Later Mar 2, 2023 28:54


The case we're going to talk about today knocked a safe, San Francisco suburb to its knees. As one friend of the victim put it, “it broke the shell of safety.” Jenny Lin was 14 years old in May 1994 when her parents weren't able to reach her at home, where she was supposed to be after school. As the workday came to an end, her father arrived home. The TV was on, but the house was empty. Calling for his younger daughter, he heads up the stairs, and it quickly set in something was wrong when he noticed the primary bedroom's bathroom door was closed. Behind that close door he found Jenny, murdered. This is her story. If you have any information about the murder of Jennifer Lin on May 27th, 1994, please contact the Alameda County Sheriff's Office at 510-667-3636, or call the Jenny Lin hotline at 855-4-JENNY-LIN. To donate to The Jenny Lin foundation, visit: https://jennylinfoundation.org/ RESOURCES: Paula Zahn s25e2  https://thecinemaholic.com/where-are-jenny-lins-parents-now/ https://jennylinfoundation.org/about-us/case-history/ https://www.latimes.com/archives/la-xpm-1994-10-02-me-45502-story.html https://www.sfgate.com/news/article/Girl-s-Family-Turns-Grief-Into-Action-Helping-3032748.php https://uncovered.com/cases/jennifer-lin https://thecinemaholic.com/jenny-lin-murder-how-did-she-die-who-killed-her/ https://crimejunkiepodcast.com/wp-content/uploads/2022/08/Timeline-1.jpg https://crimejunkiepodcast.com/wp-content/uploads/2022/08/Timeline-2.jpg https://www.oregonlive.com/pacific-northwest-news/2021/10/portland-serial-killer-sebastian-alexander-shaw-dies-in-prison-after-21-years.html https://www.newspapers.com/image/461865273/?clipping_id=54062922&fcfToken=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJmcmVlLXZpZXctaWQiOjQ2MTg2NTI3MywiaWF0IjoxNjc2OTUzOTM2LCJleHAiOjE2NzcwNDAzMzZ9.gKf_Hq5S-4yjt01bAmcG0jIPBMd6UTOezgun7y9Z1xE https://www.sfgate.com/bayarea/article/CASTRO-VALLEY-How-man-convicted-in-Oregon-2517891.php Music Used: Walking with the Dead by Maia Wynne Link: https://freemusicarchive.org/music/Maiah_Wynne/Live_at_KBOO_for_A_Popcalypse_11012017 License: https://creativecommons.org/licenses/by-nc-nd/4.0/ Our Links: Website: https://themurderdiariespodcast.com/ Patreon: https://www.patreon.com/themurderdiariespod Buy Us a Coffee: https://www.buymeacoffee.com/mdiariespod Instagram: https://www.instagram.com/themurderdiariespod/ TikTok: https://vm.tiktok.com/ZTdgBwpV1/ Edited by: https://www.landispodcastediting.com/

Captain&Morgan
Who Killed Jenny Lin?

Captain&Morgan

Play Episode Listen Later Feb 21, 2023 56:07


In 1994, a quiet suburban neighborhood was rocked by tragedy when a 14-year-old girl was found brutally murdered in her own home. Her family and friends were left reeling with shock and fear as they struggled to come to terms with the senseless crime. Despite intense efforts by law enforcement, the perpetrator has remained at large, and case has gone unsolved. Even now, decades later, the memory of the Jenny Lin lingers on, along with the hope that one-day justice will be served.   Get bonus content on PatreonSupport this show http://supporter.acast.com/crimepedia. Hosted on Acast. See acast.com/privacy for more information.

acast killed jenny lin
Positively Uncensored
Behind The Scenes of 'Tell Me Lies' ft. Lead MUA Jenny Lin

Positively Uncensored

Play Episode Listen Later Jan 14, 2023 39:09


Welcome back bitches! This week is the start of the episodes we've all been waiting for...the 'Tell Me Lies' tea!! Huge thank to Jenny Lin (the lead MUA on the show!) for coming on an episode, and sharing behind the scenes scoops from 'Tell Me Lies' season 1 and further explaining the TV and makeup magic that went into the wedding and hives scenes in the series. If you did not watch 'Tell Me Lies', this episode will still have something valuable to take away. If you have a new career ambition you are pursuing, or you are an aspiring MUA, Jenny shares her story of how she was able to go from working at MAC in the store, to working alongside some of Hollywood's largest directors and actors and the hard work that goes into achieving your goal. Stay tuned for P.U.'s next episode to hear predictions for 'Tell Me Lies' season 2, and more tea from Sadie Demarco played by Alayna Hester!! If you love this episode as much as I did, make sure to subscribe to the podcast, rate it 5 stars and follow @makeupbyjlin on Instagram to see more of her work! --- Send in a voice message: https://anchor.fm/positivelyuncensored/message

Crime Junkie
MURDERED: Jenny Lin Part 2

Crime Junkie

Play Episode Listen Later Aug 24, 2022 38:24


After days of searching for 14-year-old Jenny Lin's killer, detectives received some promising tips that left everyone hopeful they'd solve one of the most disturbing murders Alameda County had ever seen. Listen to part 1 here.If you have any information about the murder of Jennifer Lin on May 27th, 1994, please contact the Alameda County Sheriff's Office at 510-667-3636, or call the Jenny Lin hotline at 855-4-JENNY-LIN. To donate to The Jenny Lin foundation, visit: jennylinfoundation.orgTo learn more about The Deck, visit: www.thedeckpodcast.comFor current Fan Club membership options and policies, please visit https://crimejunkieapp.com/library/.Source materials for this episode cannot be listed here due to character limitations. For a full list of sources, please visit: https://crimejunkiepodcast.com/murdered-jenny-lin-part-2/

Crime Junkie
MURDERED: Jenny Lin Part 1

Crime Junkie

Play Episode Listen Later Aug 24, 2022 36:38


In 1994, the brutal murder of a 14-year-old inside her parents' safe suburban house left a community shaken to its core, because not only had a bright and talented life been suddenly snuffed out, but police struggled to find a motive. And the more clues they uncovered, the more investigators realized the nightmare they were dealing with: Jenny Lin's murder was more than a crime of opportunity —it had been carefully planned. For nearly 30 years, Jenny's murder has weighed on Alameda County and terrorized detectives as they've pondered the same question over and over since 1994: why Jenny?If you have any information about the murder of Jennifer Lin on May 27th, 1994, please contact the Alameda County Sheriff's Office at 510-667-3636, or call the Jenny Lin hotline at 855-4-JENNY-LIN.To donate to the The Jenny Lin Foundation visit: jennylinfoundation.orgTo learn more about The Deck, visit: https://thedeckpodcast.com/ Source materials for this episode cannot be listed here due to character limitations. For a full list of sources, please visit: https://crimejunkiepodcast.com/murdered-jenny-lin-part-1/

The Deck
Jenny Lin (Queen of Hearts, California) Part 2

The Deck

Play Episode Listen Later Aug 24, 2022 38:15


Our card this week is Jenny Lin, the Queen of Hearts from California.  After days of searching for 14-year-old Jenny Lin's killer, detectives received some promising tips that left everyone hopeful they'd solve one of the most disturbing murders Alameda County had ever seen. Listen to Part 1 here. If you have any information about the murder of Jenny Lin on May 27, 1994, please contact the Alameda County Sheriff's Office at 510-667-3636, or call the Jenny Lin hotline at 855-4-JENNY-LIN. There's currently a $200,000 reward for information leading to the arrest and conviction of Jenny's killer.  To donate to the Jenny Lin Foundation visit, jennylinfoundation.org. To learn more about The Deck, visit www.thedeckpodcast.com.

The Deck
Jenny Lin (Queen of Hearts, California) Part 1

The Deck

Play Episode Listen Later Aug 24, 2022 35:29


Our card this week is Jenny Lin, the Queen of Hearts from California. In 1994, the brutal murder of a 14-year-old inside her parents' safe suburban house left a community shaken to its core, because not only had a bright and talented life been suddenly snuffed out, but police struggled to find a motive. And the more clues they uncovered, the more investigators realized the nightmare they were dealing with: Jenny Lin's murder was more than a crime of opportunity —it had been carefully planned. For nearly 30 years, Jenny's murder has weighed on Alameda County and terrorized detectives as they've pondered the same question over and over since 1994: why Jenny? If you have any information about the murder of Jenny Lin on May 27, 1994, please contact the Alameda County Sheriff's Office at 510-667-3636, or call the Jenny Lin hotline at 855-4-JENNY-LIN. There's currently a $200,000 reward for information leading to the arrest and conviction of Jenny's killer. To donate to the The Jenny Lin Foundation, visit: jennylinfoundation.orgTo learn more about The Deck, visit: https://thedeckpodcast.com/ 

Inwood Art Works On Air
Live N' Local with Bob Windbiel

Inwood Art Works On Air

Play Episode Listen Later Jul 14, 2022 43:46


Cutting his teeth on Beatles, show tunes and ‘60s AM radio, Bob Windbiel first formed a blues duo with childhood pal Ralph Robbins when he was twelve years old. His high school band EDGE played rock n' roll, blues and jazz-rock fusion in the early-mid ‘70s. With the electric-avant-jazz group OUTLET he recorded three albums one of which was released on the legendary alternative jazz label ESP-Disk. He led and composed most of the material for two indie-rock bands from the mid-‘80s through the early ‘90s: Mod Lang and Marcel Monroe. Bob's hybrid, concert instrumental and vocal music has been performed by Jed Distler and Jenny Lin, just to name a few. And locally, Bob played guitar in the pit band for Inwood's Pied Piper Children's Theater for several productions while his children Bix and Genevieve were on stage.  After graduating from Lehman College, he became the electric guitar teacher at the school and formed the Lehman Guitar Ensemble, for which he arranges music ranging from classical to jazz to blues to pop to rock 'n roll.  In addition, he continues to record and occasionally perform professionally with both EDGE and OUTLET.

The Composer Chronicles
Ep. 81: ICEBERG New Music

The Composer Chronicles

Play Episode Listen Later Jun 2, 2022 83:30


What do you get when you gather ten composers, all with different musical styles, talents, backgrounds, and areas of expertise? You get ICEBERG. Featured pieces (in alphabetical order by composer last name): Unfolding for strings and live electronics by Drake Andersen Coatlicue barría la escalera del templo (Coatlicue was Sweeping the Temple Steps) by Victor Baéz pOwer trIo for alto sax, piano, and percussion by Alex Burtzos Decomposition by Yu-Chun Chien RISE by Derek Cooper Steep for strings, percussion, and celesta by Jack Frerer Clarinet Quintet by Max Grafe Source Code by Harry Stafylakis Learn more about ICEBERG and follow them on social media: Website | YouTube Facebook | Instagram | Twitter The Etudes Project album featuring Jenny Lin and ICEBERG. Lisa Pegher at Timucua Theme music is by Daryl Banner. Alexandrian Media podcast music by Andrew Gavin. Voiced by Michael Bolton. Listen to this episode early and ad-free by supporting The Composer Chronicles on Patreon. Sign up for Amazon Music Unlimited! | Alexandrian Media Store --- Send in a voice message: https://anchor.fm/thecomposerchronicles/message

The Arc
Authenticity

The Arc

Play Episode Listen Later Nov 16, 2021 56:12


This episode is about authenticity. Hosted by SCI-Arc History + Theory coordinator Marrikka Trotter, the Arc considers the relationship between the authentic and the fake in fashion and art with Jenny Lin, associate professor of critical studies at University of Southern California's Roski School of Art and Design; the consciousness-expanding experience of co-authoring a novel with AI with writer and artist K Allado-McDowell; and how Neolithic edifices might be considered an authentic reference for contemporary small-scale housing in Los Angeles with SCI-Arc faculty Anna Neimark.

The Data Standard
Data Standard Audio Experience with Jenny Lin PhD, Senior Data Scientist, Pandora

The Data Standard

Play Episode Listen Later Aug 21, 2020 19:48 Transcription Available


Host Darren Kaplan sits down with Jenny Lin PhD, Senior Data Scientist, Pandora to talk about Data Science for the environment.You can connect with Jenny Lin via Linkedin: https://www.linkedin.com/in/jenny-x-lin/For more information about The Data Standard visit https://datastandard.io/The Data Standard LinkedIn: https://www.linkedin.com/company/the-data-standard/

Ryto allegro
Ryto allegro. Skulptorius Arūnas Bielskis: meno kūrinyje logikos neturi būti

Ryto allegro

Play Episode Listen Later Aug 5, 2020 88:24


Kultūros naujienos spaudoje. Užsienio įdomybių apžvalga. „Minint Ferdinando Ruščico 150 metų jubiliejų, NDG ekspozicijoje „atkūrėme“ simbolinį jo auksinį kambarį. Įsivaizduojamame auksiniame kambaryje susipina F. Ruščico moderni europietiška patirtis ir bajoriška savimonė, meilė miestui ir konfliktiškas patriotizmas“, – aiškina parodos „Auksinis kambarys“ kuratorė dr. Algė Andriulytė.Kas yra savaiminės dainos? Apie dainų, atliekamų prieš 200 metų ir dabar, bendrybes, ir žvilgsnį į dainą kaip į per laiką kintantį procesą, pasakoja knygos „Savaiminė daina“ autorė dr. Aušra Žičkienė.Galerijoje „Arka“ Vilniuje pirmą kartą atidaryta Arūno Bielskio personalinė paroda „Solo“. Su menininku kalbasi kolegė Laima Ragėnienė. Ieva Buinevičiūtė pasakoja apie Justino Hurwitzo muziką D. Cahzelle filmui „Pirmasis žmogus“.Domanto Razausko leidybinės muzikinės naujienos, kartu su pianiste Jenny Lin ir jos Philipo Glasso muzikos albumu, su džiazo gigantus įrašui sukvietusiu bosininku Billu Laswellu ir su jauna ambient muzikos kompozitore Juliana Barwick.

Kitas laikas
Kitas laikas. Sugadintas Beethoveno metronomas ir muzikinės leidybinės naujienos

Kitas laikas

Play Episode Listen Later Jul 30, 2020 47:19


Pirmojoje laidos dalyje – rubrika „Muzikos enšteinai“ ir pasakojimas apie metronomo atsiradimą klasikinėje muzikoje. Šio įtaiso išradimas siejasi ir su Ludwigu van Beethovenu, kuris buvo pirmasis savo kūriniuose ėmęs žymėti tempą pagal metronomą.Tačiau šių laikų mokslininkai įtaria, kad metronomo išradėju apsišaukęs, su didžiuoju kompozitoriumi bylinėjęsis ponas Johannas Nepomukas Maelzelis Beethovenui specialiai pakišo sugadintą metronomą ir dėl to romantiko kūrinio tempo žymėjimai kartais tokie keisti, kad kai kurie dirigentai, pianistai yra linkę į juos žiūrėti pro pirštus. Antrojoje laidos dalyje – tradicinės muzikinės leidybinės naujienos su pianiste Jenny Lin ir jos Philipo Glasso muzikos albumu, su džiazo gigantus įrašui sukvietusiu bosininku Billu Laswellu ir su jauna ambient muzikos kompozitore Juliana Barwick. Laidą veda Domantas Razauskas.

laid kitas laikas muzikos naujienos pirmojoje muzikin jenny lin antrojoje philipo glasso ludwigu
Community Matters
Elliott Sharp

Community Matters

Play Episode Listen Later Apr 14, 2020 26:47


“The people that I connect with online come from all over the musical world, from contemporary composition, from blues, from free jazz, from rock music, from noise… To me it's just all music. I've never felt those barriers were hard and fast — they were imposed by someone else.” Elliott Sharp has been one of the key figures in the avant-garde and experimental scenes in New York City since the late 1970s. With close to 100 releases spanning jazz, noise, orchestral, no wave, contemporary classical, and electronic music, his career can really only be described as prolific. He studied with icons like Morton Feldman, Roswell Rudd, and Robert Moog. His compositions have been performed by renowned ensembles like the Kronos and FLUX quartets. He's released music for the alt rock SST label alongside bands like Sonic Youth and Hüsker Dü. He's collaborated with everyone from jazz legend Jack DeJohnette to Blondie's Debbie Harry to Wilco's Nels Cline to Nusrat Fateh Ali Khan, the Pakistani Qawwali singer regarded as having one of the most impressive voices ever recorded. We chatted about the halcyon '60s when people thought of all kinds of music as simply music, when genrification didn't really stratify how we think about what we hear. We also spoke of the evolution of community alongside the emergence of online platforms, and the importance of resonance when it comes to making music and finding others to make it with. And for budding experimental artists, Elliott offered some wisdom into how they can find their people and work toward making a living. Support Elliott Sharp: www.elliottsharp.com/ Music in this episode, used with permission from Elliott Sharp: The Boreal  (excerpt) -  performed by JACK Quartet Flexagons (excerpt) - performed by Elliott Sharp and Orchestra Carbon Port Bou: Words  (excerpt from opera) - performed by Nicholas Isherwood with Jenny Lin, William Schimmel, and Elliott Sharp Koinoinia - performed by Elliott Sharp on Koll 8-string guitarbass --- Send in a voice message: https://anchor.fm/greymatterfm/message

Super Awesome Science Show (SASS)
Smells of the Season

Super Awesome Science Show (SASS)

Play Episode Listen Later Dec 2, 2019 35:15


As we get ready for the holidays we thought we would share with you this episode about the smells of the Holiday Season in case you missed it in the hustle and bustle of the most wonderful time of the year. On this week’s episode of the Super Awesome Science Show, we stick our noses into the science of smelling, scientifically known as olfaction, and find out how certain scents can draw out attention, bring back memories, and even affect our buying behaviour. We first talk with Dr. Leslie Cameron at Carthage College. She’s been studying how we detect and recognize odours throughout life and how we can equate some aromas with the festive season. Next we hear from renowned smellosopher, Dr. Ann-Sophie Barwich at Indiana University Bloomington. She’s examining how certain odours can be autobiographical in nature leading us to open up memories of times of past Holidays and other moment long gone by. In our SASS Class, we speak with Dr. Jenny Lin at California State University Monterey Bay. She’s researching how the sense of smell affects our brains through what is known as event-related potential. As she tells us, the right combination of odours may prompt us to stick around in a store and inevitably buy more.  If you enjoy The Super Awesome Science Show, please take a minute to rate it on Apple Podcasts or Google Podcasts, tell us what you think and please tell a friend about the show. Twitter: @JATetro Email: thegermguy@gmail.com Guests: Dr. Leslie Cameron, Carthage College Website: https://www.carthage.edu/live/profiles/261-leslie-cameron Dr. Ann-Sophie Barwich, Indiana University Bloomington Twitter: @smellosopher Website: http://www.smellosophy.com/ Dr. Jenny Lin, California State University Monterey Bay Website: https://csumb.edu/directory/people/jenny-lin

Hot for Justice: Cold Case Stories
Episode 11: What the Duck

Hot for Justice: Cold Case Stories

Play Episode Listen Later Jul 1, 2019 42:06


This week, Jessica covers the solved case of Christina & Levi Karlsen. Jaymie covers the cold case of Jenny Lin.  Every Monday we will be bringing you information on cold cases and other true crime stories. Please subscribe and be sure to leave us a rating and review to let us know what you think!  Find us on social media:   Facebook: @hotforjusticepodcast Twitter: @hot4justicepod Instagram: @hotforjusticepodcast     Other places to find us:   Jaymie- Twitter: @jayymiss94 Instagram: @freestylingfitness Blog: freestylingfitness.blogspot.com   Jessica- Twitter: @japenrose1 Instagram: @jessicaapenrose

duck jaymie jenny lin
Super Awesome Science Show (SASS)
Smells of the Season

Super Awesome Science Show (SASS)

Play Episode Listen Later Dec 24, 2018 36:01


We are all familiar with the sights and sounds of the Holiday Season. But what about the smells? They have an enormous impact on us and can influence how we celebrate the most wonderful time of the year. On this week’s episode of the Super Awesome Science Show, we stick our noses into the science of smelling, scientifically known as olfaction, and find out how certain scents can draw out attention, bring back memories, and even affect our buying behaviour. We first talk with Dr. Leslie Cameron at Carthage College. She’s been studying how we detect and recognize odours throughout life and how we can equate some aromas with the festive season. Next we hear from renowned smellosopher, Dr. Ann-Sophie Barwich at Indiana University Bloomington. She’s examining how certain odours can be autobiographical in nature leading us to open up memories of times of past Holidays and other moment long gone by. In our SASS Class, we speak with Dr. Jenny Lin at California State University Monterey Bay. She’s researching how the sense of smell affects our brains through what is known as event-related potential. As she tells us, the right combination of odours may prompt us to stick around in a store and inevitably buy more.  If you enjoy The Super Awesome Science Show, please take a minute to rate it on Apple Podcasts or Google Podcasts, tell us what you think and please tell a friend about the show. Twitter: @JATetro Email: thegermguy@gmail.com Guests: Dr. Leslie Cameron, Carthage College Website: https://www.carthage.edu/live/profiles/261-leslie-cameron Dr. Ann-Sophie Barwich, Indiana University Bloomington Twitter: @smellosopher Website: http://www.smellosophy.com/ Dr. Jenny Lin, California State University Monterey Bay Website: https://csumb.edu/directory/people/jenny-lin

Success @ Sinai
Ep. 5: Mentors

Success @ Sinai

Play Episode Listen Later Oct 31, 2018 9:51


Everybody, I repeat, EVERYBODY, needs a mentor. Today on S@S, Drs. Juan Wisnivesky and Jenny Lin explain how to find the right mentor and build a strong mentoring relationship at Mount Sinai. Music credits: "Something Elated" by Broke For Free (brokeforfree.com/) "Colocate" by Podington Bear (www.soundofpicture.com/) Mix by Ben Kruse

Absolute Trust Talk
013: Deciphering International Tax Law with Jenny Lin

Absolute Trust Talk

Play Episode Listen Later Aug 7, 2018 34:55


Absolute Trust Talk welcomes Walnut Creek international tax law expert Jenny Lin to the show. Lin has been practicing tax law since obtaining her juris doctor degree in 2000 from U.C. Berkeley and is one of approximately 400 attorneys certified as a tax specialist by the State Bar of California Board of Legal Specialization.   In this episode, Kirsten and Jenny dive into the complexity that is foreign taxes, focusing on the importance of seeking out the proper help when it comes to cross-border tax planning to avoid some of the steep penalties that can come from not filing correctly. Kirsten and Jenny also discuss international estate planning for foreign individuals with U.S. beneficiaries and U.S. individuals with foreign assets.    Big Three From Episode #013: If you find out you’re noncompliant somehow, seek out international tax attorney help – don’t wait! Evaluate your situation Don’t panic   Time-stamped Show Notes: 3:25 – There are lots of forms that need to be filed in regards to having foreign assets and income, but this one by far has the biggest penalty.    4:10 – Kirsten and Jenny discuss willfulness penalties and what the IRS looks for when looking into someone’s foreign assets. 7:03 – Jenny talks about three compliance programs that allow people to file the proper paperwork and come into compliance. 10:52 – Jenny shares what foreign assets, such as life insurance are treated differently in foreign countries compared to the U.S.   12:55 – A foreign parent or family member needs to watch out for this when gifting someone in the U.S. 17:12 – What steps should a U.S. citizen with a foreign asset take in terms of the estate planning process? 22:05 – What do spouses – one who is foreign and one who is not – need to think about in terms of future planning? 24:22 – Kirsten and Jenny discuss how one asset might have more than one reporting requirement.    Episode #013 Freebie: International tax is a very focused area and oftentimes people have a misunderstanding about what the requirements are. We even find that some tax practitioners miss some important conditions as well. Absolute Trust Talk guest Jenny Lin shares eye-opening insights about international taxes in this episode, and now she’s sharing even more. If you find yourself in international tax trouble, or just want to know if you’re keeping up, then Jenny’s list of common IRS forms you need to file and her guide to come into compliance are precisely what you’ve been looking for. Click here to download the Information Return & Compliance Options guide now!

Sounds Like Portraits
Jenny Lin, pianist: “my daily life is almost a constant preparation for my life on stage.”

Sounds Like Portraits

Play Episode Listen Later Mar 16, 2018 24:15


When I sat with Jenny, she told me about her dedication to her creative process: “My daily life is almost a constant preparation for my life on stage.” But she also told me about her teaching process which is also a creative one. 

Getting Personal: Omics of the Heart
10 AHA Sessions Recap and FGTB YIA

Getting Personal: Omics of the Heart

Play Episode Listen Later Dec 19, 2017 30:20


Jane Ferguson:                Hello, I'm Jane Ferguson and you are listening to Getting Personal: Omics of the Heart, the podcast from Circulation: Cardiovascular genetics, and the functional genomics and translational biology council of the AHA. This is episode ten, from November 2017.                                            November is always a big month for AHA and the annual Scientific Sessions were held in Anaheim, California, November 11th through 15th. For those of you who were able to attend, hopefully you came away feeling refreshed and invigorated and with your desired level of Disney merchandise. For those of you who could not attend, or who didn't make it to all of the genomic sessions, this month's episode should catch you up.                                            For the past several years, the FGTB Council has been organizing boot camps at AHA sessions to give people a chance for hands on learning in a flipped classroom model. This year was no exception and in addition to a clinical genomics boot camp focused on patient centric genomics including single gene testing, whole genome sequencing and pharmacogenomics there was also a new boot camp focused on tackling big data network systems analysis for high input data interpretation.                                            These boot camps are always very well attended and popular, so if you're interested in attending one next year, make sure to get in early and sign up during registration. There was also a hands on session in collaboration with the AHA's Precision Medicine Institute to teach people how to use the precision medicine platform to further their research.                                            In addition to this, there was a full day of programming related to precision medicine in the precision medicine summit, which is held on the Tuesday of Sessions. That covered topics ranging from big data, electronic health records, collaborations and the All of Us initiative to rapid fire reports from ongoing consortium, large scale analysis to disease specific approaches in cardiomyopathy.                                            We were planning to have an in depth focus on the Institute for Precision Cardiovascular Medicine in a future podcast episode, so stay tuned for more on that coming soon. There were a number of individuals who were recognized for their contributions to science and we would like to congratulate all of these outstanding individuals.                                            The FGTB medal of honor was awarded to Stuart Cook from the Duke National University of Singapore. The FGTB mentoring award was awarded to Robert Gerszten from Beth Israel Deaconess Medical Center. The FGTB distinguished achievement award went to Sekar Kathiresan from the Broad Institute. And the functional genomics and epidemiology mid-career research award went to Kiran Musunuru from the University of Pennsylvania. Congratulations to all of these.                                             One of the highlights for the FGTB council at sessions is the FGTB young investigator award. This award celebrates early career investigators and recognizes outstanding research in basic science, populations science, genetic epidemiology, clinical genetics and translational biology. Four finalists presented their research on the Sunday afternoon sessions and I had the chance to chat with all four of them before and after their presentations. So listen on for a behind the scenes over view of the finalists research and the announcement of the winner.                                            Mark Benson is a cardiology fellow at Brigham and Women's Hospital and is working on post-doctoral research at the Beth Israel Deaconess Medical Center in Boston with Dr. Robert Gerszten. His talk was entitled "The Genetic Architecture of the Cardiovascular Risk Proteum." Mark Benson:                  My name's Mark Benson. I'm just finishing up a cardiology fellowship at Brigham and Women's Hospital and am in the middle of post doc in Robert Gerszten’s lab at Beth Israel. Jane Ferguson:                Great, and congratulations on being chosen as a finalist for the FGTB Young Investigator Award. We would love to hear a little bit more about what you’re working on and what you're gonna be telling us. Mark Benson:                  Yeah, absolutely. So the goal of the project was really to integrate proteomic data with genomic data, with the idea that we may be able to use the overlap between those data sets to identify potentially novel biological pathways that underlie very early cardiovascular disease risk.                                            And the thinking behind that was that the lab had just finished up applying DNA-aptamer-based proteomic platform to profile over 110 proteins and the Framingham-Offspring Cohort and from that work, we had identified a very specific signature of 156 proteins in plasma that were each very strongly associated with cardio-metabolic risk.                                            The idea was while those associations were very strong, it was unclear if we were capturing cart or horse or how these associations were fitting together. We wanted to incorporate the genomic data to try to get a better handle on that, to try to connect those pathways to see how these proteins might actually associate with the end phenotype of risk. Jane Ferguson:                It's a sort of Mendelian randomization-esque. Mark Benson:                  Exactly, yeah. So what we were able to find in doing this, we were able to use peripheral blood samples from participants at the Framingham-Offspring study. With a validation in participants of the Swedish Malmo Cancer and Diet Study. Then we did protein profiling using commercial DNA aptamer platform, soma scan. What we were able to find is we were able to detect very strong associations between these circulating cardio metabolic risk-proteins and genetic variance.                                            What was fascinating was we were able to see many things. We were able to start mapping where are these associations, where are these genetic variance in relation to, for example, the gene that's coding the protein that we're measuring. That had some interesting implications because for about half of the protein that had significant associations, we could track those genetic variance back to the gene. It was coding the protein that we were measuring, which was interesting because it's validating the specificity of the proteomic platform that we're using. Jane Ferguson:                Right that's nice, because so often you found a gene that's nothing related to what you think it's going to be so it's nice actually the gene you expect. Mark Benson:                  Yeah, it's very reassuring too when you're looking at rows and rows and rows of data. When the top association of the p value of 10 in the minus 300 is the actual gene you thought would be coding the protein that you're measuring. So that was very reassuring, but we also found dozens and dozens and dozens of associations that were totally unexpected and that may point to completely unexplored biological pathways in cardiovascular disease. So that was obviously very exciting.                                            That actually led us to do two things. One was to make all these data available publicly on dbGaP because as a resource for cardiovascular research there is just way too much data for one group or a handful of groups to digest. The other thing that was fun about the project, is we were able to take one association that was particularly interesting for a number of reasons and experimentally validate it in a tissue-culture model. Jane Ferguson:                So how did that work? Mark Benson:                  So this was an interesting challenge where we all of a sudden got all of these hits back, which was probably to be expected, but to try to figure out which of these dozens and dozens and dozens of new, unexpected hits, what do you do? There was one hit, one association, that was particularly strong and it was between several variance around this gene. That's a phosphatase called PPM1G. It's a transcription factor.                                            These variants, which was interesting, were associated with several different circulating cardio metabolic risk proteins. So our idea was, isn't that interesting? Is it possible that this is mapping to some central regulator? And so it fit that that would be ... that the nearest gene to these variants was a transcription factor and could be a central regulator.                                            What made it more interesting to us was that several variants in the GLGC had recently been described that were highly associated with circulating levels of total cholesterol and triglycerides and they were located around this PPM1G locus as well. The association between those variants and circulating cholesterol didn't have a clear biological connection.                                            So what our work had shown is that those same variants were associated with circulating levels of apolipoprotein E. So wouldn't that be interesting if these variants mapped to PPM1G, the transcription factor, this PBM1G in turn regulated circulating apolipoprotein E and that would provide some insight into the biology behind the GLGC findings.                                            So sure enough we were able to knock down PPM1G using SRNA and hepatocytes and then see that that led to a significant down regulation of the transcription of Apo-B and extra-cellular presumably secreted Apo-B in this model, which is kind of a nice proof of principal that this idea of integrating proteomics and genomics may lead to some novel biological pathways. Jane Ferguson:                Yeah, it's really interesting. So what's next. There are probably a lot more associations that you're going to have to go after? Mark Benson:                  Yeah, I think that what this showed us is that this seems like a powerful tool. Joining these orthogonal data sets to find new pathways and so we're continuing to pursue that with an increasing number of proteins for example, so we're doing genome-wide association studies and x-gamma rays. We've gone from 156 to 1100 to 1300 and are now going beyond that and so as those numbers get higher, you start to see these central nodes come together and more interesting targets and potential pathways. It's also interesting to use these data to find new associations or new tools that you would never think to look for as ways to modulate protein levels.                                            So you can imagine, for example, one thing that we've been exploring for the last few months is can we identify, for example, SNP associated with an interesting circulating protein. That SNP maps to an enzyme or some other druggable mechanism and very preliminary studies, it seems like the answer is probably yes, but there is still a lot of work to be done. Jane Ferguson:                Well that's cool. That sounds really interesting. Mark Benson:                  Yeah, I think the key thing is that all these data will soon be out there and so it's a very rich data set and I think there are many ways that we could use the data. Jane Ferguson:                So is that the genomic data and all the proteomic data or it's the summary of the those associations? Mark Benson:                  All the genomic data, all the proteomic data and the associations as well. You can do the associations yourself if you'd like to. Jane Ferguson:                We can find that  dbGaP. Awesome, well thank you for talking to us. Mark Benson:                  Thank you. It's been fantastic. Jane Ferguson:                Congratulations again. Mark Benson:                  Thanks so much. ... Jane Ferguson:                Jenny Lin is an instructor at the University of Pennsylvania, working with Dr. Kiran Musunuru. Her presentation was entitled, "RNA binding protein A1CF Modulates Plasma Triglyceride Levels through Transcriptomic Regulation of Stress-Induced BLDL Secretion".                                            Jenny, can you take a moment to introduce yourself? Jenny Lin:                          Yes, hi. Thank you for this opportunity to participate. I'm Jenny Lin. I'm an instructor of medicine at the University of Pennsylvania, a nephrologist by clinical training, but training in cardiovascular research in Kiran Musunuru's lab. Jane Ferguson:                So congratulations for getting selected as a finalist for the Young Investigator Award. We'd love to hear a little bit more about what you've been presenting and what you've been working on. Jenny Lin:                          Thank you. So basically, what I've been working on over the past year is functional follow-up of this A1CF locus, which is a novel locus for triglycerides. So say Sek Kathiresan's group recently published in Nature Genetics and x and y association study on plasma lipids involving more than 300,000 individuals.                                            One of the key findings from that study is this strong association between a lo-frequency coding variant and elevated plasma triglycerides. So we wanted to delve more deeply into the biology for why we have that genotype/phenotype connection. One of the key things that we wanted to do was ... A1CF is not a stranger to lipo-protein metabolism, but we wanted to see what else it may be doing outside of its canonical role of facilitating the editing of Apo-B messenger RNA.                                            It really took us on a little bit of a wild journey using different unbiased approaches to try to figure out some of the mechanisms that could be behind it. Jane Ferguson:                So you had to do a lot of different types of experiments to really get at this question. Jenny Lin:                          Yeah. So again, one thing we wanted to see was: if you lose A1CF function, whether or not you would have differences in Apo-B 100-B48. We actually found that A1CF isn't even needed for that editing reaction and that our mice that we were able to create with crispr cas9 genome editing, so knocking in the mutation and knocking out the gene, actually have the phenotype even though they don't have changes in editing.                                            But what surprised us was that we know that A1CF as an RNA binding protein binds Apo-B transcript, yet it somehow does not alter transcriptional abundance of the Apo-B messenger RNA. And it has nothing to do with Apo-B synthesis so we basically had to think, what is A1CF doing outside of Apo-B biology?                                            We found that you have A1CF loss of function, you have increased triglycerides secretion. There is more Apo-B secretion, but that seems to be a downstream effect of other processes going on in the cell and to really try to figure out what those processes are, we had to take an unbiased approach using enhanced clipseek to figure out binding targets and also doing some transcriptional profiling with RNA sequencing and found that it's not necessarily regulating that transcriptum on a differential expression level, but there are some key alternative splicing events as well as messenger RNA binding to affect translational efficiency of some key targets that could be driving the biology. Jane Ferguson:                That's really interesting and you wouldn't have been able to find that by just looking at levels of protein or levels of mRNA, you really had to do these additional clipseek and some experiments to really get at this splicing. Jenny Lin:                          Yeah, so it's been interesting. Clipseek is not as commonly performed method, so we had to collaborate with some brilliant people over at UCSD, to help us facilitate this. But again, finding that A1CF binds many more transcripts than Apo-B itself is a novel finding and the fact that it can regulate alternative splicing is also a very novel finding as well. Jane Ferguson:                So what was the most challenging part of this whole project? Jenny Lin:                          I think the challenging part was that when we saw there wasn't necessarily a direct effect on Apo-B abundance and having to then cast this wide net and then figure out from all of the different unbiased data we have and integrating it find different pathways that may be relevant. In this case, it may all be relevant to ER stress, which is a field that is a little bit controversial in VLDL secretion in terms of directionality, but certainly is important in the biology. Jane Ferguson:                So is that something that you're going to have to start doing in the future? Are you going to start looking at ER stress or what kind of other experiments do you think you're going to keep doing to move this project forward? Jenny Lin:                          Yeah, so actually, I think focusing in on A1CF as an RNA-binding protein and pursuing some of these additional targets will also be relevant, so I think in terms of ER stress, we could be looking at different targets, but there other processes going on in the cell that's mediated by A1CF, that could contribute maybe doing some isoform specific studies just to really prove that these alternative-splicing changes are driving some of the biology.                                            There's a lot of work to do as I would joke to anyone on study section listening to this, perhaps four to five years of work for an RO1. Jane Ferguson:                Sounds very appropriate. Jenny Lin:                          Yeah, there's a lot of exciting work to do. A1CF is actually also a locus for other cardio-metabolic relevant traits such as uric acid, gout and kidney function so there could be something very interesting going on. There could be cross talk among cellular processes that could lead to these different phenotypes. Jane Ferguson:                Really interesting project and a lot of really great work. Congratulations again on being selected as finalist and on this really interesting paper. Jenny Lin:                          Thank you. Jane Ferguson:                Thanks.                                            Sarah Parker is based in Cedar Sinai Medical Center in LA and her mentor is Dr. Jenny Van Eyk. The title of her presentation was "Identification of Putative Fibrous Plaque Marker Proteins by Unsupervised Deconvolution of Heterogeneous Vascular Proteomes ". And I apologize in advance for the quality of this recording. The background noise wasn't that noticeable at the time, but that recording really gives you that full immersive audio experience of a busy hotel lobby.                                            Hey Sarah. Thank you for joining us. Could you just take a few moments to introduce yourself to the audience? Sarah Parker:                   So I'm Sarah Parker. I'm a project scientist at Cedar Sinai Medical Center where I'm doing work to study the basic mechanisms of vascular biology of various indolent conditions. Jane Ferguson:                So congratulations on being selected as a finalist for the Young Investigator Award. It's a great achievement. I'd love to hear a bit more about your project, how that started and what you found. Sarah Parker:                   The work that I did was under the overarching umbrella of a project called the Genomic and Proteomic Architecture of Atherosclerosis. So with this project, we're using tissues that we're able to obtain from individuals who are young and have passed away from traumatic and violent and so non-cardiovascular causes of death. Because of the presence of atherosclerosis in the population, we get this range of lesion, both fatty streak and fibrous-plaque lesions in these asymptomatic or non-diseased individuals and this gives us this opportunity to do some molecular profiling to really try to find protein-signatures of early stage plaque formation, that could ultimately and hopefully be used for biomarker development. Jane Ferguson:                That's really cool and that's such a valuable sample resource. Sarah Parker:                   Yeah so we've essentially, in this project I was able to set up a pipeline that enabled us to do these proteomics on such a large scale, because that's actually really difficult in label free quantitative proteomics and to use other forms becomes very expensive and cost-limiting.                                            So we were able to find a panel of proteins that we think are a putative early set of fibrous plaque markers and with this panel, we took them to see if any of these tissue derived markers would then be detectable and informative in plasma, because that's the next really big translational leap with these discovery-type data sets. Of our 58 initial candidates, we were able to detect 39 of them and about a handful 10-13 are showing informative behavior in the plasma of initial cohort of women with known coronary-artery disease. Jane Ferguson:                So out of the 58 that you first found, how many of them were potentially known to be involved in disease and how many were novel? Sarah Parker:                   I would say, going through the list, it was probably about 50/50 in terms of background data that shows role as a biomarker, so there are a lot of apolipoproteins, which have all been characterized as potential biomarkers. There were a lot that could feasibly be linked through the literature to atherosclerosis. Most of them made a lot of sense, but having been proposed as potential biomarkers, some of them were more rare. Jane Ferguson:                Were there any of them that were sort of in different directions, let's say were elevated in tissue, but then were lower in plasma? Sarah Parker:                   Funny you should ask. That actually has us scratching our heads a little bit right now. There were a couple of apolipoproteins that are more associated with HDL biology that we saw as being elevated in the tissue but then lower in the plasma [inaudible 00:23:34] so that's a really interesting observation so something about the role of these proteins to scavenge cholesterol and then once they're in the blood, they're cleared really quickly relative to normal, or something. So we're really trying to figure out what that biology means. Jane Ferguson:                Maybe if they're building up in the tissue, that's bad. But while in circulation, they're fine. Sarah Parker:                   Yeah, maybe they're trapped in the circulation. We have a lot of exciting hypotheses to test along that front. Jane Ferguson:                So what's next? Are you following up some of these proteins? Sarah Parker:                   Yep, so we have a huge discovery arm to the project where we're looking for more molecular mechanisms like why do we have these things in the tissue versus plasma and then we are working to really validate and optimize these multi-plexes in much more generalized large-scale populations to determine whether this strategy of instead of one or two biomarkers, more of a signature-style panel can be informative, especially as we try to press towards a precision medicine approach where different substratum might be informed by different protein signatures. Jane Ferguson:                Right, so you might have to have a specific panel based on sex or age or race or some other demographic. Sarah Parker:                   Yes and to find those signatures, it's going to be very big numbers, with very accurate, careful quantitation. Jane Ferguson:                So you have a lot of work to do. Sarah Parker:                   Yes. Jane Ferguson:                Alright, well thank you for talking to us and congratulations again.                                            Louie Wang, a cardiologist and PhD student came all the way from the Victor Chang Cardiac Research Institute in Syndey, Australia. His mentor is Dr. Diane Fatkin. The title of his talk is "A novel zebrafish model of human A-band truncated titan exhibits alternated ventricular diastolic compliance in vivo and reveals enhanced susceptibility to the effects of volume overload in mutation carriers.                                            So thank you for joining me. Could you take a few minutes to introduce yourself? Louie Wang:                     So I'm Louie Wang. I'm a cardiologist based in Australia. I work and live in Sydney. I'm a PhD student at the Victor Chang Cardiac Research Institute and I'm an NHMRC (National Health and Medical Research Council and National Heart Foundation of Australia post-graduate scholar). I have previously been based at St. Vincent's Hospital. Jane Ferguson:                Great. So we'd love to hear a little bit in advance of what you're working on and what you're planning to present. Louie Wang:                     So basically what I'm presenting is what I think is a different form of functional of genomics. What we're actually looking at is the impact of genetic changes, specific genetic change on function of the heart at an organ level. So there is a problem out there that is very common in cardiology and it's a big problem in cardiology and that is there are mutations in the sarcomere protein titan, truncating variants which actually are associated with dilated cardiomyopathy.                                              Now they're pretty common in idiopathic dilated cardiomyopathy, present in about 15-20% of the cases depending on which cohort study you look at. But they're also widely prevalent in the general population. Somewhere between 0.3 to 1% of the general population carries this truncating variants or various forms of this truncating variant.                                            So it's not sure whether these are disease-causing in their own right or if it's just a genetic susceptibility factor for heart failure and so what our work involves is that we actually, by chance, at St. Vincent's Hospital and at Victor Chang Cardiac Institute, two families who had the identical genetic truncation in the A-band region of his human titan gene where the individuals in the family, typically who carried the gene, typically developed systolic heart failure, which is a mild phenotype and occurred at middle age, but in two individuals, they developed severe onset accelerated disease trajectory in a very severe phenotype when exposed to conditions associated with chronic volume overload.                                            We suspect and this was a hypothesis, not only was this genetic-truncation disease-causing, but at volume overload was disease-modifying and given that volume overload is a very common condition present in birth, a lot physiological processes like lung endurance, exercise, pregnancy as well as a lot of pathological disease states in cardiovascular disease, this was actually a very important modifiable factor.                                            So what we did, was we created a novel zebrafish model of this human A-band truncated variant. We then studied the animals when they became adults to look at their heart structure and function and we used zebrafish echocardiography. So reversed translated all the techniques you can do in human echocardiography so they can be used in the zebrafish.                                            What we found was, yes, this animal, or heterozygotes developed dilated cardiomyopathy but also the volume overload exacerbated this condition. So this is a phenomenon that has conserved this by four hundred million years of vertebrate evolution so this is a pretty important mechanism. Jane Ferguson:                So what kind of next steps do you see for this project? Louie Wang:                     So one thing is that we obviously have shown that there is an association with volume overload in precipitous disease. The corollary of our work is that perhaps interventions that could reduce volume load in these genetic susceptible individuals or alternatively in people who can't avoid volume overload. Because a lot of volume overload conditions can be modifiable and perhaps this could be protective and that would have wide-ranging population benefits. Jane Ferguson:                Thank you for sharing that soundbite of your work and good luck. Congratulations again on becoming a finalist. Louie Wang:                     Thank you. ... Jane Ferguson:                Each of these four finalists gave compelling presentations of their research and the judges were highly impressed of the quality of the research and level of accomplishments of these early career investigators.                                            Just getting selected as a finalist for this award is a huge accomplishment. But there did have to be one winner. I'm delighted to announce that Jenny Lin was selected as the 2017 FGTB Young investor award winner. Congratulations, Jenny, and thanks to all four finalists for agreeing to appear on this podcast.                                            And that's all for this month. We'll be back at the end of December with a new episode. Subscribe to the podcast through iTunes or your favorite podcast app. to get new episodes delivered automatically and thank you for listening.

Relevant Tones
Above and Beyond

Relevant Tones

Play Episode Listen Later Jul 18, 2015 58:24


In recent years composers have become interested in the fact that the performers can do things on stage other than just play their instrument: stomp their feet, clap, play simple percussion, and even sing. We'll feature a variety of pieces from composers who ask musicians (who are not trained singers) to vocalize and supplement their playing. Hosted by Seth Boustead Produced by Jesse McQuarters Leonard Bernstein: “Mambo” fr. West Side Story Simon Bolivar Youth Orchestra of Venezuela/Dudamel Frederic Rzewski: De Profundis, section 1 & 2 Milton Schlosser, p. Valentin Silvestrov: Drama Sonate for Violin and Piano Cornelius Duffalo, v. Jenny Lin, p. Tom Johnson: Counting Duets Tim Munro, vocals Joseph Hallman: imagined landscapes: six Lovecraftian elsewheres Inscape/Richard Scerbo Martin Bresnick: Willie's Way (excerpt) Lisa Moore, p. Huang Ruo: Drama Theater No. 4, To the 4 Corners, Scene II (excerpt) FIRE/Ruo Steve Reich: Clapping Music (excerpt) Pierre Laurent Aimard, hand claps

Relevant Tones
Jenny Lin

Relevant Tones

Play Episode Listen Later Jul 11, 2015 58:22


Stunningly versatile pianist Jenny Lin has recorded with jazz musicians, rockers, contemporary composers and everyone in between. Equally comfortable playing Shostakovich on the same concert as giving a world premiere, Lin is a vital talent that is taking concert halls by storm. Hosted by Seth Boustead Produced by Jesse McQuarters George Gershwin: I Got Rhythm (excerpt) Earl Wild, arr. Jenny Lin, p. James Tenney: Chromatic Canon Lin, p. Arthur Kampela: Nosturnos (excerpt) Lin, p. Valentine Silvestrov: Sonata for Violin and Piano, Post Scriptum (excerpt) Cornelius Duffalo, violin; Jenny Lin, p. Elliot Sharp: Suberrebus (excerpt) Lin, p. David Wolfson: Sonata for Cello and Piano, IV Laura Bontrager, vc.; Jenny Lin, p. Claude Vivier: Shiraz Jenny Lin, p. William Bolcolm: Dream Shadows from Three Ghost Rags Lin, p.

Science Out Loud
Trippy Shapes

Science Out Loud

Play Episode Listen Later Nov 24, 2014 4:48


In school, you learn about shapes with sides and edges - but there are weird shapes out there (beyond our 3 dimensions) that defy our normal idea of geometry. QuanQuan and Jenny explain, knit, and 3D print their way through trippy shapes! ---------- Awesome MIT videos on physics, high speed cameras, MIT course materials, educator resources, and QuanQuan and Jenny's bios can be found here: http://k12videos.mit.edu/trippy-shapes ---------- Find us online! Facebook: http://www.facebook.com/MITK12 Twitter: http://www.twitter.com/MITK12Videos http://k12videos.mit.edu ---------- made with love at MIT Creative Commons: CC BY-NC-SA, MIT http://k12videos.mit.edu/terms-conditions Hosted by: Jenny Lin & QuanQuan Liu Written by: Jenny Lin & QuanQuan Liu Additional scripting: Elizabeth Choe, George Zaidan, Tyler DeWitt Executive producer: Elizabeth Choe Director: George Zaidan Editors: Jessica Harrop, Per Hoel Production assistants: Conor Olmstead, Dan Martin Music: "Blue" Mikuś Meets 66North (http://freemusicarchive.org/music/Miku_Meets_66North/Planetarium/Blue_1521) "Ascent of Sham" krackatoa (http://freemusicarchive.org/music/krackatoa/Dining_On_Backs_of_the_Brave/Krackatoa_-_Dining_on_Backs_of_the_Brave_-_05_Ascent_of_Sham) Special thanks: Chris Haid and AJ Perez at NVBots (http://www.nvbots.com); John Essigmann and Simmons Hall

Café Concerts
Café Concert: Jenny Lin

Café Concerts

Play Episode Listen Later Feb 25, 2014 17:24


An upright piano may not seem like the desired tool of a keyboard purist but Jenny Lin needed little rationalization for playing Igor Stravinsky’s Firebird Suite on the upright in the WQXR Café. Stravinsky himself was said to compose not at a concert grand, but "at a tacky-sounding and usually out-of-tune upright piano that has been muted and dampened with felt,” according to a onetime description by his wife, Vera Stravinsky. What’s more, Stravinsky’s teacher, Rimsky-Korsakov, advocated using uprights in orchestra works, arguing for their tinny, delicate sounds over thick, chordal opulence. The instrument may have also underscored the Russian folk sounds that characterize many of Stravinsky's early works. The Taiwan-born, New York-based Lin also plays Stravinsky on the big grands, something she has been doing a lot lately. Her newest album is a collection of a dozen of the composer's solo piano works, and while many of them aren’t so well known – perhaps lacking the surging passions or flamboyant calisthenics employed by other Russian composers – she believes they have much to admire and enjoy. "We really should know more about Stravinsky as a piano music composer because he composed a lot of the orchestra music on piano, and he was a very good pianist himself,” said Lin. Along with original solo piano pieces like the Sonata and the Serenade, there are some finger-twisting arrangements, notably Guido Agosti’s transcription of the Firebird Suite. Here Lin plays work’s the Danse infernale: Lin discovered Agosti’s Firebird transcription while studying in Italy as a teenager and that got her hooked on Stravinsky's work. “He's clever as a composer,” she noted. “He knows what gets an audience and can trigger the adrenaline.” While Lin’s concert repertoire includes the hefty concertos of Beethoven and Rachmaninoff, her discography tells of a more eclectic sensibility, spanning "InsomniMania," a collection of pieces inspired by nighttime dreams and anxieties, and "The Eleventh Finger,” devoted to complex modernists like Gyorgy Ligeti, Elliott Sharp and others. In the WQXR Café she also performed a selection from "Get Happy: Virtuoso Show Tunes for Piano.” The 2012 album featured arrangements of Broadway songs by such noted pianist-composers as André Previn, Stephen Hough, Marc-André Hamelin and Alexis Weissenberg. “One should not take these pieces very lightly,” said Lin. “I have to say, I thought that doing the Broadway arrangement project would easy because of the tunes but it was the hardest thing I’ve had to do, because every pianist just took the tune and went off with it.” Below is Lin’s performance of Gershwin’s Embraceable You, in an arrangement by the late Earl Wild: Video: Amy Pearl; Sound: Edward Haber; Text & Production: Brian Wise; Interview: Jeff Spurgeon