Podcasts about mind research institute

Dementia is the leading cause of death for Australian women. Unless we find a cure soon it's estimated that 812,500 people will be living with dementia by 2054. But dementia is not inevitable. Professor Ian Hickie from the Brain and Mind Research Institute has a few tips for preventing it.See omnystudio.com/listener for privacy information.

Looking to elevate STEAM learning in your classroom? Discover TinkRworks — the evidence-based STEAM learning system designed for K-8 educators. TinkRworks engages students in unprecedented ways through innovative, STEAM Project-based Learning. The easy-to-implement program focuses on the hands-on application of STEM concepts and deepens cross-curricular connections to computer science, language arts, engineering, math, science, and the arts. Developed by a team of educators and engineers, TinkRworks provides comprehensive resources that enhance lesson plans, support project implementation, and ensure alignment with educational standards. Join the growing community of TinkRworks educators. Visit TinkRworks.com/podcast for special pricing. In this episode, I sit down and chat with Nigel Nisbet. He's the Vice President of Content Creation at MIND Research Institute and loves the ST Math product they've designed. He's a life long educator and has a passion for students overcoming math adversity through critical thinking and problem solving. ST Math is a platform in which students interact with Gigi, they're penguin mascot, and get her to move about the screen by solving math problems. We have a great discussion around productive struggle, his educational background, and where ST Math is going next. Check this episode out and see if you could get your students to move Gigi. Buen provecho! Connect With Gabriel Carrillo EdTech Bites Website: https://edtechbites.com EdTech Bites Twitter: https://twitter.com/edtechbites EdTech Bites Instagram: https://instagram.com/edtechbites EdTech Bites Threads: https://www.threads.net/@edtechbites EdTech Bites Facebook Page: https://facebook.com/edtechbites EdTech Bites YouTube Channel: https://www.youtube.com/@edtechbites About Nigel Nisbet Experienced mathematics educator and interactive curriculum designer who believes learning is something that students do, not something that happens to them. Connect With Nigel and MIND Education MIND Education Website: https://www.mindresearch.org/ MIND Education On Twitter: https://x.com/MINDEduOrg MIND Education On Instagram: https://www.instagram.com/mindeducationorg/ MIND Education On Facebook: https://www.facebook.com/MINDEduORG/ MIND Education On LinkedIn: https://www.linkedin.com/company/mindeducation/ MIND On YouTube: https://www.youtube.com/user/mindresearch Nigel Nisbet On LinkedIn: https://www.linkedin.com/in/nigelnisbet/ The Book Is Officially Out! My first book “Cooking Up Experiences In The Classroom: Focus On Experiences, Not Just Lessons” is officially out! A HUGE shout out to Lumio for helping sponsor this book. I'm super excited about this project. It's filled with ideas on how to make memorable experiences for your students. In addition, each chapter also lays out a specific recipe mentioned in that chapter along with a video tutorial on how to prepare that dish. Make sure you get your copy and cook up some experiences for your students and loved ones! Click Here To Purchase Your Copy On Amazon

What is actionable? What is real engagement? LeiLani discusses these things, and a novel definition of equity with Dan Tracy from MIND Research Institute. Dan's triple threat as a teacher, coder and trainer, makes this podcast discussion an interesting reveal on how to approach instruction – especially the subject of math.

A discussion with Ki Karou about the challenges of teaching today. Karou introduces five areas that the science of learning have identified as key to students' doing – and how those are aids to accelerating learning, including the awesome capability of helping learners potentially jump through multiple grades to catch up in little time. Listen in to learn about things the neuroscience has uncovered including “self belief,” “schema building,” and more.Ki Karou is the Senior Director of Product Content at MIND Research Institute, where he leads a team oflearning and game designers, artists and mathematicians. Ki has been designing neuroscience-driven ed tech solutions for over a decade and is widely published and a top speaker in the edtech industry.

A discussion with Ki Karou about the challenges of teaching today.  Karou introduces five areas that the science of learning has identified as key to students' doing – and how those are aids to accelerating learning, including the awesome capability of helping learners potentially jump through multiple grades to catch up in little time.  Listen in to learn about things the neuroscience has uncovered including “self belief,” “schema building,” and more.  Ki Karou is the Senior Director of Product Content at MIND Research Institute, where he leads a team of learning and game designers, artists and mathematicians. Ki has been designing neuroscience-driven ed tech solutions for over a decade and is widely published and a top speaker in the edtech industry.

In this episode of the Learning Leadership Society Podcast, Host LeiLani Cauthen speaks with Nigel Nisbet, Vice President of Content Creation at the MIND Research Institute. Nisbet shifts the question from ‘How should I teach,' to ‘How do they learn?' It's a profound difference which helps you to focus on optimal learning methodologies, and to gain an understanding of the Science of Math.

In this episode of the Learning Leadership Society Podcast, Host LeiLani Cauthen speaks with Twana Young, Vice President of Curriculum and Instruction for Mind Research Institute. In addition to access, Young explains that there's also agency and power and identity and belonging, and those are all part of the different dimensions of equity, especially around mathematics. As Mind Research Institute builds out content and curriculum, they are thinking about the opportunities for agency, and who has the power. It is a fascinating look at equity through a different lens.

In this episode of the Learning Leadership Society Podcast, Host LeiLani Cauthen speaks with Twana Young, Vice President of Curriculum and Instruction for Mind Research Institute. In addition to access, Young explains that there's also agency and power and identity and belonging, and those are all part of the different dimensions of equity, especially around mathematics. As Mind Research Institute builds out content and curriculum, they are thinking about the opportunities for agency, and who has the power. It is a fascinating look at equity through a different lens. 

In this episode of the Learning Leadership Society Podcast, Host LeiLani Cauthen speaks with Nigel Nisbet, Vice President of Content Creation at the MIND Research Institute. Nisbet shifts the question from ‘How should I teach,' to ‘How do they learn?' It's a profound difference which helps you to focus on optimal learning methodologies, and to gain an understanding of the Science of Math. 

Medical practitioners of all specialties may lack Cassandra's divinely inspired prophetic powers, but our training, research, and deep consideration for our patients' wellbeing inform our prognostication. We hope that in this way, we are able to serve as guideposts along their ultimate paths. Judy Ch'ang, medical director of the Neurointensive Care Unit and assistant professor in the Department of Neurology and Clinical and Translational Neuroscience Unit at the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine, and Nara Michaelson, a fourth-year neurology resident at Weill Cornell Medicine, reflect on how difficult it is for physicians to explain the intricacies of prognostication to patients' family members. The essay read in this episode was published in the Teaching and Learning Moments column in the November 2022 issue of Academic Medicine. Read the essay at academicmedicine.org.

Nicole Chu from the University of Ottawa speaks with Dr. Adam Shuhendler, an associate professor at the University of Ottawa and a Canada Research Chair (Tier 2) in Chemical Biology. He is also cross-appointed to the UOHI, and is affiliated with the University of Ottawa Brain and Mind Research Institute where he is a member of the Concussion Injury Group. In this episode, Dr. Shuhendler shares how his team at the Molecular Medicine Lab is optimizing medical imaging technologies such as PET and CEST-MRI to screen for diseases on a molecular level. Learn more: https://www.molmedlabuo.com/

Description: Margaret Elizabeth Ross, M.D., Ph.D. is a Nathan Cummings professor in neurology and director of the Center for Neurogenetics at the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine in New York. To learn more, check out the Ross Lab website! 1:30 Introduction 4:00 An Intro to AI 10:15 What are Neural Tube Defects? 16:30 Publications from the Ross Lab 21:00 The Ross Lab's Use of AI 30:00 Clinical Applications of Genetic Research 31:00 Spina Bifida Outcomes 32:00 Health Equity in Genetics 36:40 What's Next? 42:00 What's the future of AI in Medicine? 43:40 Advice for your Past Self 45:00 Advice for Medical Student/Physicians 48:00 Final Words of Wisdom Intro Music - Windows96 - Caligula (song used with permission from artist). Host: Madeline Ahern Producer: Melanie Bussan Cover Art: Saurin Kantesaria Follow us on twitter @themamlpodcast Email us! contact@themamlpodcast.com Looking for industry sponsors!

ABOUT THE AUTHORS ED FULLER Since 2012, Ed Fuller has been an adjunct professor of Leadership at the University's College of Hospitality in Pomona and San Diego State University. He is also an adjunct professor at the Paul Merage School of Business @ the University of California, Irvine. He serves as a Board Member of The Mind Research Institute. He is also a former Director of the FBI National Academy Associates Foundation. Mr. Fuller served as a Captain in the U.S. Army and was awarded the Bronze Star and Army Commendation Medal for service during missions in Vietnam and Germany. GARY GROSSMAN Gary Grossman is a print and television journalist, an Emmy Award-winning network television producer and a film and TV historian. He has worked as producer for NBC News, ABC, CBS NBC, and 29+ cable networks. Grossman is a partner with in Weller/Grossman Productions a documentary production company. He began his career at 15 as a disc jockey at WHUC, his local radio station in Hudson, New York. Grossman lives in Los Angeles with his wife, writer Helene Seifer, and their children Sasha, Zachary, and Jacob. He is a member of the International Thriller Writers Association. ABOUT THE BOOK - RED DECEPTION  When terrorists bomb bridges across the country and target the Hoover Dam, America's vulnerable infrastructure becomes a matter of national security. But Dan Reilly, former Army intelligence, predicts the attacks in a secret State Department report written years before. Somehow the report gets leaked and is now in the hands of enemies. With D.C. distracted by domestic crises, the Russian President sends troops to the borders and is ready to reclaim Russia's rightful territory. Tensions in Europe threaten to boil over as a besieged American president balances multiple crises that threaten to upend the geopolitical order.  

Do you consider yourself a Math person? Most people don't, and unfortunately the statistics back this up. Just 24% of high school 12th graders scored at or above proficient on the National Assessment of Educational Progress. Karin Wu and her team at the MIND Research Institute believe that expertly designed educational games can help shift Math from frustrating to fun. STMath, the game developed by her team, is based on cutting-edge neuroscience and education research. In this episode, we discussed the potential impact of games like STMath and the power of preparing students for the unknown future they will face.You can follow Karin Wu on Twitter @KarinCWu and read more about the MIND Research Institute at www.mindresearch.org.Support Learning Machine PodcastSupport the show (https://www.patreon.com/LearningMachine)

Norm Kelk et al, ‘Courting the Blues: Attitudes towards Depression in Australian Law Students and Lawyers' (Report, Brain and Mind Research Institute, University of Sydney, January 2009) - BRMI Reporthttps://www.ibanet.org/Mental-wellbeing-in-the-legal-profession - IBA Wellbeing Surveyhttps://mindscount.org/wp-content/uploads/2019/09/TJMF-workplace-wellbeing-guidelines-.pdf - Tristan Jepson Memorial Foundation Best Practice Guidelineshttps://www.lawcouncil.asn.au/policy-agenda/advancing-the-profession/equal-opportunities-in-the-law/national-report-on-attrition-and-re-engagement - NARS Surveyhttps://lsbc.vic.gov.au/resources/lawyer-wellbeing-report - Victorian Legal Services Board and Commissioner Lawyer Wellbeing Projecthttp://classic.austlii.edu.au/au/legis/nsw/consol_reg/lpulascr2015658/index.html- Legal Profession Uniform Law Australian Solicitors Conduct Rules 2015Kozarov v State of Victoria [2020] VSC 78, in which a former public prosecutor was awarded damages due to her employer's failure to take reasonable steps to protect her from mental harm in her employment.  Victoria v Kozarov [2020] VSCA 301 (24 November 2020)Kozarov v State of Victoria [2021] HCATrans 101 (21 May 2021) Special leave granted for High Court Appeal)

For much of the history of neurology, diagnosing a genetic disease meant giving bad news. Genetic meant incurable, often fatal. On past shows, we've talked about how this narrative is changing for certain monogenic diseases like Huntington's Disease, where emerging gene therapies offer hope for a cure. But what hope can the field of neurogenetics offer to patients with more complex diseases with both genetic and environmental risk factors, like Alzheimer's? Our guest today, Dr. M. Elizabeth Ross, is Professor of Neurology and Neuroscience in the Brain and Mind Research Institute and Director of the Center for Neurogenetics at Weill Cornell Medicine. Her lab works on the genetics of neurologic diseases affecting humans at every stage of the lifecycle. Today she'll help us understand the role of genetics in a range of neurodegenerative diseases -- and how and when clinicians should incorporate genetic considerations into patient care. Series 2, Episode 8

From drug cocktails to deep brain stimulation, there is new hope for brain-injured patients with "locked-in syndrome”  in minimally conscious states. Dr. Nicholas Schiff, Professor of Neuroscience at the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine, tells the dramatic stories of patient reawakenings from ​comas lasting many years.

Welcome to the NeurologyLive Mind Moments podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.     In this episode, we're joined by Costantino Iadecola, MD, Anne Titzell Professor of Neurology, and director and chair, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine. He discussed the shortcomings of the current clinical approach to Alzheimer disease and offered insight into how vascular risk factors play a role in its pathology. Thanks for listening to the NeurologyLive Mind Moments podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com (http://neurologylive.com/) .

How important are the research phases of UX and product development? Alicia connects with Alesha Arp, a Senior UX Research at MIND Research Institute. MIND is an EdTech math organization supporting K12 students and educators. They chat about the role of research in developing educational technology products. Connect with Alesha Arp: Twitter: @AleshaArp (https://twitter.com/aleshaarp?lang=en) LinkedIn: https://www.linkedin.com/in/alesha-arp-078b853/ MIND Research Institute: https://www.mindresearch.org/ Connect with Alicia & the Podcast: Twitter: @ux_edtech (https://twitter.com/UX_EdTech) Instagram: https://www.instagram.com/ux_edtech/ LinkedIn: https://www.linkedin.com/in/alicia2joy/ Music: Scott Buckley Send in your thoughts and perspectives! --- Send in a voice message: https://anchor.fm/ux-edtech/message

**Follow us on Twitter - @InstantRel** Rate and Review us on iTunes On Episode 30 of the Instant Relevance Podcast, Denis (@MathDenisNJ) and Raymond (@blended_math) talk to Calli Wright (@CalliWrights) - Education Engagement Manager for MIND Research Institute (@MIND_Research) . The hosts ask Calli about the work of MIND Research Institute , their flagship math program STMath, and the power of play in the classroom. More from MIND Research Institute: -- mindresearch.org STMath: -- stmath.com Check out more from Denis: -- denissheeran.com/ Check out more from Ray: -- blendedlearningnetwork.org/ The Instant Relevance Podcast is a proud member of VoicEd.ca and the Education Podcast Network - www.edupodcastnetwork.com

Imagine an all-encompassing platform that allows you to keep track of all your blood, stool, saliva, and urine testing results, along with self-quantified data from wearables, and even pulls in all health testing you've done in the past as part of a single dashboard. And imagine that platform could then use highly advanced artificial intelligence to tell you exactly how to eat, how to supplement, how to exercise and much more. All from the comfort of your home, without needing to drive to an expensive lab for multiple blood draws or fill out confusing paperwork. That's exactly what the brand new company has the money, technology and data to do, and so I decided it was high time I sat down with their two chief scientists to learn exactly how this process works. I've already sent in my own stool using their Gut/bio shotgun stool sequencing test that we discuss in this episode. My guests are Dr. Joel Dudley and Dr. Chris Mason.  These guys are highly qualified and wicked smart. Dr. Dudley is currently Associate Professor of Genetics and Genomic Sciences, Endowed Chair of Biomedical Data Science, and founding Director of the Institute for Next Generation Healthcare at the Icahn School of Medicine at Mount Sinai. Prior to Mount Sinai, he held positions as Co-founder and Director of Informatics at NuMedii, Inc. and Consulting Professor of Systems Medicine in the Department of Pediatrics at Stanford University School of Medicine. His work, published in >120 peer-review publications, is focused at the nexus digital health, artificial intelligence (AI), scientific wellness, and healthcare delivery. His work has been featured in the Wall Street Journal, Scientific American, MIT Technology Review, CNBC, and other popular media outlets. He was named in 2014 as one of the 100 most creative people in business by Fast Company magazine. He is co-author of the book Exploring Personal Genomics from Oxford University Press. Dr. Dudley received a BS in Microbiology from Arizona State University and an MS and PhD in Biomedical Informatics from Stanford University School of Medicine. Dr. Christopher Mason is currently an Associate Professor at Weill Cornell Medicine, with appointments at the Tri-Institutional Program in Computational Biology and Medicine between Cornell, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medicine, the Sandra and Edward Meyer Cancer Center, and the Feil Family Brain and Mind Research Institute. He is also Director of the WorldQuant Initiative for Quantitative Prediction, which bridges prediction methods in finance with genomics. His work spanning >140 peer-reviewed publications has been featured on the cover of Science, Nature, and Cell journals as well as the New York Times, Wall Street Journal, CNN, Forbes, and other major media outlets. Dr. Mason was featured as a speaker at TEDMED and he was recognized in 2014 as one of the “Brilliant Ten” by Popular Science magazine. He completed his dual B.S. in Genetics and Biochemistry (2001) from University of Wisconsin-Madison, his Ph.D. in Genetics (2006) from Yale University, and then completed post-doctoral training in clinical genetics (2009) at Yale Medical School while jointly a post-doctoral Fellow of Genomics, Ethics, and Law at Yale Law School (2009). During the show, you'll discover: -What is, and what it does...9:45 "Health intelligence" company History of the company Frustration with how long it takes research to reach the consumer 17 years to reach just the clinic; many years after that to reach the consumer How is it different from other biome testing companies Shotgun sequencing vs. 16S Translate the results along with actionable steps to take Recreational health information vs. health management companies Vertically integrated with Thorne, who develops the actual solutions Starting over in some ways in the realm of microbiome testing -What is metatranscriptome analysis?...18:00 "Meta" = Across all species DNA + RNA analysis Challenges with RNA analysis - some clinicians consider it useless Only top few % of species generate RNA in the sample Comparable in price to shotgun sequencing -The actual testing process at Onegevity...20:45 Very small stool sample required, as compared to other tests 6 gigabytes of data after sequencing DNA Each fragment compared to all known species on earth Interactive report on the web; suggestions on what food and supplements to order Network modeling: How are changes in the microbiome propagating to the blood More comprehensive than guessing based on correlations What is measured in the blood? TBD based on the individual's health -How Joel and Chris overcome challenges and skepticism in their testing processes...28:20 How can you measure the whole gut with a stool sample? (Spatial microbiome testing) Not necessary, even harmful, to sample from other areas of the gut -The role of artificial intelligence (AI) in the testing process at Onegevity...36:40 Predicts diseases/conditions based on the shotgun sequencing Recommend foods and supplements to consume Each company has its own variables, testing protocols, etc.; results in differing test results Database continues to grow with each test; data becomes more reliable Data is not for sale to outside parties; will partner under the right conditions -How do you go from stool, to shotgun sequencing, to "don't eat green beans?"...40:35 Internal trial; shocking results Can determine the efficacy of the test at certain benchmarks; 15 day, 30 day, etc. Very positive feedback from those who were tested Does Thorne produce a special probiotic that seeds the gut? -How comprehensive are the dietary recommendations after a Onegevity test?...48:52 Not simply a particular diet, i.e. Mediterranean, Ketogenic, etc. Can make specific food, meal recommendations Possibly partner with food delivery services to provide customized options Very close to being perfectly genetically tailored in both microbiome and saliva tests -How customer data is protected if Joel and Chris choose to partner with a pharmaceutical company...55:20 Customers are opted out by default; can choose to opt in. Potential to benefit monetarily by opting in -What the Onegevity platform looks like from a user standpoint...1:01:55 -And much more! Resources from this episode: - Use discount code BEN20 to receive $20 off your own test. -Book: Exploring Personal Genomics by Joel Dudley Episode Sponsors: - My own company where I develop coffees, energy bars and supplements. I'm also proud to endorse the Thorne line of supplements, including the multi-vitamin, which I take every day. - Wake up each day feeling rested. Relax your body after a long day. Help stiff joints feel young again. Use discount code “greenfield” and get 20% off your entire order! - Your Favorite Organic Foods and Products. Up to 50% Off. Delivered to Your Door. Use my link and get an extra 25% off your first order. - Gently push your body into Ketosis in a healthy manner so your body turns into a fat-burning machine (and stays in fat-burning mode). Get 15% off your order when you use my link. Do you have questions, thoughts or feedback for Joel, Chris or me? Leave your comments at http://bengreenfieldfitness.com/onegevity and one of us will reply!

Professor Esther M Sternberg MD and Professor Ian Hickie AM How do the emotions affect our physical and mental health? What is the science that shows how brain and body interact to make us sick or well? Two of the world’s leading researchers exposed and explored the pathways within the brain through which our emotions connect with our bodies. Professor Sternberg presented the results of her decades of research showing how nerves, molecules, and hormones connect the brain and immune system, how the immune system signals the brain and affects our emotions, and how our brain can signal the immune system, making us more vulnerable to illnesses. She illustrated how these links work and discussed what the implications can be for treatable and chronic diseases. Professor Hickie discussed studies conducted by the Brain and Mind Research Institute that indicate the role the emotions play in the developing adolescent brain and identify, which factors are likely to lead to serious mental illnesses such as schizophrenia, and the ways in which early interventions might be used to prevent and treat these diseases. A Sydney Ideas event on 14 October, 2010 sydney.edu.au/sydney_ideas/lectures/2010/professor_esther_sternberg.shtml

  Carolyn: Welcome to Circulation on the Run. Your weekly podcast summary and backstage pass to the journal and it's editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. I am so pleased to be joined this week by Dr. Judd Hollander and Dr. Deborah Diercks to discuss a problem that all of us, as cardiologists and emergency department physicians will recognize. This is a feature paper on the state of the art approach to the patient presenting to the emergency department with symptoms and signs suggestive of an acute coronary syndrome, but first here are the highlights of this weeks issue.     The first study is from first author's Dr. Wing and Dr. August from Grand Valley State University in Michigan who investigated whether social and physical neighborhood characteristics are related to progression of sub clinical atherosclerosis measured by coronary artery calcium. They studied this in almost six thousand adult participants of Mesa, a multi-ethnic study of atherosclerosis, followed over twelve years. The main result was that increases in density of neighborhood healthy food stores were associated with decreases in coronary artery calcium. This was significant even after adjusting for time varying demographic confiders, time varying behavioral risk factors and depression.     The next study from Dr. Hess and colleagues from the University of Colorado School of Medicine characterized rates of implantable cardioverter defibrillator or ICD counseling and ICD use among more than twenty-one thousand potentially ICD eligible hospitalized heart failure patients in the Get With the Guidelines heart failure program. This study had several notable findings. First, only twenty-two point six percent of patients received ICD counseling. This means that up to four out of five hospitalized heart failure patients, eligible for ICD counseling, did not receive it. Women were counselled less often than men and racial or ethnic minorities were counseled less frequently than white patients.     Among counseled patients, a totally of sixty-two point six percent of patients received an ICD or had a documented plan for ICD placement. Women were just as likely as men to receive an ICD, however, ICD used differences by race and ethnicity persisted. The clinical implications of this study are that future quality improvement initiatives should incorporate culturally competent ICD counseling and elevating ICD counseling to a full performance measure and publicly reporting it by sex or race or ethnicity may need to be considered.     The next paper is from first author Dr. Resconey and corresponding author, Dr. Catalucci and colleagues from the Institute of Genetic and BioMedical Research in Milan, Italy. These authors looked at the voltage dependent [inaudible 00:03:31] calcium channel which is a key mediator of interest [inaudible 00:03:34] calcium entry associated with various cardiovascular conditions such as hypertrophy, atrial fibrillation, hypertension and diabetic cardio myopathy. The author's aim to address the problem that [inaudible 00:03:47] approaches aimed at enhancing calcium current and inotropism in heart failure have also frequently been found to favor arrhythmogenesis and diastolic dysfunction. Thus, limiting their clinical use.     The novel hypothesis addressed in this study is that a peptidome emetic therapeutic approach may overcome the arrhythmogenic limitations of current channel activator inotropes. To test this hypothesis, the author's used a whole host of methods to dissect new regulatory pathways modulating the [inaudible 00:04:24] tight calcium channel life cycle. This included yeast, two hybrid screenings, biochemical and molecular evaluations, protein interaction essays, fluorescence, microscopy, and structural molecular modeling and functional studies. Having uncovered a novel mechanism involving the [inaudible 00:04:44] tight calcium channel, calcium beta two chaperon, the author's then generated a mimetic peptide that specifically targets this calcium beta two chaperon. Thereby controlling the channel assembly and density of the plasma membrane while preserving its physiological channel function.     Finally, they showed that delivery of this mimetic peptide into a mouse model of diabetic cardiomyopathy restored calcium balance and recovered cardiac function. This study is so significant because it provides the proof of concept for the exploitation of novel therapy based on mimetic peptide technology. Really opens the field to mimetic peptides being used as innovative therapeutic tools for the treatment of cardiac disease.     The last study is from Dr. Cammel from the Feil Family Brain and Mind Research Institute in New York and colleagues who studied the association between pregnancy and aortic complications such as dissection or rupture. They used data on all emergency department visits and acute care hospitalizations at nonfederal health care facilities in California and New York between the period of 2005 to 2013. This was a cohort crossover study where they authors defined the period of risk as six months before delivery until three months after delivery. Compared each patient's likelihood of aortic complications during this high risk period to an equivalent control period of two hundred and seventy days exactly one year later.     Among more than six and a half million pregnancies in almost five million women, they identify thirty-six cases of aortic dissectional rupture during the high risk pregnancy period and nine cases during the control period. This gives the rate of aortic complications a five point five per million patients during pregnancy compared to one point four per million during the equivalent period one year later. Thus, pregnancy was associated with a significantly increased risk of aortic dissectional rupture with an incidence rate ratio of four compared to the control period one year later.     Furthermore, absolute risks were particularly elevated in those with a documented diagnosis of hypertension or a connective tissue disease. These findings have clinical implications for the counseling of patients at high base line risk of aortic complications and they also further suggest that clinicians may need to have a lower threshold for initiating diagnostic testing for symptoms of a possible aortic dissection or rupture in pregnant or postpartum patients and especially in those with connective tissue disorders or hypertension.     Our feature paper this week discusses a problem that impacts twenty million patients in North America and Europe every year. What am I talking about? These are patients presenting to the emergency department with symptoms and signs suggestive of an acute coronary syndrome. Who am I talking with? Well, today we have first author Dr. Judd Hollander from Thomas Jefferson University and Dr. Deborah Diercks associate editor from UT Southwestern. Welcome Judd and Deborah.   Dr. Deborah: Thank you.   Dr. Judd: Thank you.   Carolyn: Let's start with a behind the scenes look at this paper. It's an in depth review that was invited by the editorial team. Deborah, can you tell us how this idea came about?   Dr. Deborah: I think one of the goals of the editorial board of circulation is really to provide great clinical reviews that really could benefit the members. I have a unique aspect in that I'm an emergency physician. This idea was really brought about by discussion of really what can we merge cardiology and emergency medicine with. What would be the most clinically issue we're challenged with right now? You can't get two emergency physicians in a cardiologist's room together without some discussion and challenge around the [inaudible 00:09:11].     There's been so many changes in the last decade and so much more information about how we can use these in a clinically relevant way. It really fit nicely into a really great review article and I am really happy that we are able to invite Judd who's well known to the US and one of the leaders in the United States in this area and also an international group inviting a cardiologist from Europe and also an emergency physician from New Zealand to participate in it.   Carolyn: Judd, what is the take home message of this in depth review from your point of view?   Dr. Judd: I think the biggest take home message is we have known for decades and decades that if we rely on our clinical judgement we miss too many patients. We send home people that will be having acute coronary syndromes and acute myocardial infraction and the challenge over the last decades of trying to find ways where we're not going to spend a ton of money over admitting people to the hospital because of a fear of missing an event that may happen five percent of the time.     The beauty of the advances in troponins is we now have troponins that now have increasing sensitivity whether they be the non high sensitivity troponins used in the US or the high sensitivity troponins that are actually used in Europe and the rest of the world. We can use those better [inaudible 00:10:29] and combine them with clinical decision rules to create accelerated diagnostic pathways which is a big term. For now, if we put a blood test together with a structured clinical decision rule, we can, with more than ninety-nine percent negative predictor value, find patients who are safe to send home.   Carolyn: Judd, I really have to congratulate you on such a beautiful paper. You really did cover all of that but what I love most is the way that you've managed to summarize very clearly a whole wealth of information because when you talk about biomarkers, there's so many out there and there's zero hour, one hour, two hours, this score and that score. I'm actually looking at table one now where you show a summary of the biomarkers strategies and then, in table two, you show a summary of the risk scores and then the performance measures of each of these scores. That must have taken quite a lot to put together.   Dr. Judd: I think that's why Deb was very smart and invited authors from around the world. We have Christian Muller from Switzerland and Martin Tann from New Zealand which, literally, means we're all on different time zones and we were able to work around the clock to do that. There as always somebody awake. Getting more series, the nice thing is that my colleagues on this paper are some of the leaders in doing this kind of research. In fact, they are the leaders in doing this kind of research.     What I think is very challenging for the average cardiologist or the average emergency physician is there have been so many different approaches and many of them actually work. The challenge for us was to try and make it relatively simple so you can choose the approach at your institution and put it into a structured pathway and pick the one that works best for you. You can get a ninety-nine percent negative predicted value using the right essays with samples that the time of presentation and one hour later, you can get a ninety-nine percent negative predictor value at zero and two hours. You can combine it with an accelerated diagnostic pathway and do that at zero and two hours and zero and three hours.     I think the important thing is you need to figure out what will your clinicians use? Certain clinicians may be very comfortable with one risk score and not another and then they need to combine the timing of testing with the risk score their comfortable with in order for us to achieve the great possibilities we have with these new tasks. I think when you try and do a one size fits all, there are going to be people who push back because they don't like one component of the risk score. Really what we're trying to do and we didn't say everybody should do A, B or C but we present the data on five or six different options and let people choose what is most feasible for them.   Carolyn: How wonderful. Deborah, what were you thinking when you were reviewing this paper and trying to structure it for the clinician out there who wants to use this information?   Dr. Deborah: I think that, overall, we were really impressed by the clarity and the ease that a reader can take this information home. There is so much information out there and there are so many different ways to apply it that we're really impressed how the authors put it in a really pretty clear manner so you can actually see the risk stratification tools that are out there, what they're used with and what type of troponins. Think about your own clinical practice and what you can adapt really based on the evidence that is out there.   Carolyn: I couldn't agree more. Judd, how about this issue of the coronary CT angiogram and where that falls?   Dr. Judd: That's really an interesting question because there's been a lot of publicity and a lot of editorializing in recent years that maybe you can make a decision with your two troponins and your biomarkers and decrease the number of people that need downstream testing. One of the dilemma with this, like I said before, is we know we're not really good at predicting who has acute coronary syndrome based on clinical things and for that reason the European Society guidelines as well as the American AHAACC guidelines have always said you need to do two things. You need to rule out acute myocardial infraction and you need to risk stratify patients for underlying coronary disease. When a patient comes into the emergency department, if I'm going to be guideline compliant with the recommendations in the world, I need to do both things.     The paper, we summarize really clearly ways you can get out of the woods with biomarket testing and clinical pathways but then you still want to risk strategy for coronary disease. There are sometimes where you might not need that downstream testing but what coronary CTA really lets us do is it makes us more efficient than a stress test. A stress test I like to say is a next day test; although there is data that you can do it when the patient's in the emergency department rapidly. It certainly is not the standard practice.     There are people afraid of putting people on the treadmill too soon in case they have unstable angina but a coronary CTA lets me look at the coronary arteries, immediately, when they're in the emergency department. There's very few areas in emergency medicine where there are three large randomized control trials that all give the same results. It doesn't say coronary CTA is better than a next day stress test but it does say you can avoid admission and, hence, save some dollars. It says you can send patients home sooner and, hence, save some angst that the patients may feel while they're in that diagnostic indecision area.   Carolyn: That's such a practical summary and, in fact, it really reflects the entire paper which is really so clearly presenting the information. Judd, one last thing, could I check is this correct, in my understanding, that the main difference between this and say the guidelines that you just measured is that what you do here is really give the readers all the information? As you say, allow the readers to choose what suits them best. This is not making recommendations, it's summarizing all the information. Is that right?   Dr. Judd: Yeah, that's exactly right. If you look, I think it's table number four, where we go through each one of the decision aids and how many or what percent of patients actually fit into that decision aid and what the negative predictive value is for that decision aid combined with troponin. Then what type of troponin was used to achieve those results, you'll see that about half the studies are done with, what we call, the contemporary troponin or just the regular sensitivity troponin that we use in the United States. The other half of the data we show is with high sensitivity troponins. It would not be a good idea for somebody creating their quality program in their emergency department to take something that was tested with a high sensitivity troponin and validate it there and then apply it in an emergency department in the United States where we don't have those [inaudible 00:17:18].     We thought it was critically important to lay out the data and as the high sensitivity troponins come on the market, hopefully in the next year in the US, people can begin with something now and switch to something else later if they want. If we made a recommendation that was firm, the world changes too fast. I don't think we would be doing the best for our patients.   Carolyn: That is such a great statement to end this on. Thank you so much Judd and Deborah. This was an excellent discussion.   Dr. Judd: Thank you.   Dr. Deborah: Thank you.   Carolyn: You've been listening to Circulation on the Run. Thank you for joining us this week and don't forget to tune in next week for more exciting cardiology needs from all over the world.    

Today, our guest is Nicholas Schiff, the Jerold B. Katz Professor of Neurology and Neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medical College, where he serves as Professor of Neuroscience, Neurology, and Public Health. He also co-directs CASBI, the Consortium for the Advanced Study of Brain Injury at Cornell. We'll be speaking with him about the anterior forebrain mesocircuit in impaired cognitive function following brain injury.

PROFESSIONAL LEARNING FOR COMMON CORE READINESS It's coming your way no matter what you call it. The Manager of Instructional Consulting at Mind Research Institute, Erich Zeller and his guest , Huntington Beach California Assistant Superintendent Jennifer Shepard. Considering the weather here in Maine, I may be making a personal visit soon. This link was mentioned on the show: http://www.wested.org/resources/stmathevaluation2014/   www.mindresearch.org  @mind_research

Our guest is MIND Research Institute CEO and Co-Founder dr Matt peterson on the incredibly successful Community Math Fair in orange County and how they are taking it on the road! Plus a look at how understanding neuroscience affects student learning!

THE NATIONAL TITLE 1 ASSOCIATION The upcoming Conference: Leading with Wonder We welcome incoming Association  President  Marcus  E. Cheeks, Director of Federal Programs at The Mississippi Department of Education Presented by MIND RESEARCH INSTITUTE  www.mindresearch.net. @mind_research

THE NATIONAL URBAN ALLIANCE FOR EFFECTIVE EDUCATION Eliminating the Gap between Potential and Achievement Alliance President Eric Cooper is our guest Presented by MIND RESEARCH INSTITUTE  www.mindresearch.net @mind_research

LINDA GOJACK, NCTM PRESIDENT CORDIALLY WELCOMES YOU TO THE BIG EASY ON APRIL 9-12 FOR THIS IMPORTANT ANNUAL EVENT ESPEICALLY IN THE YEAR OF THE COMMON CORE. JOIN THE CORE, LISTEN IN..AND THANK YOU MIDN RESEARCH INSTITUE FOR SPONSORING THIS PROGRAM

COMMON CORE: The Transition in Pinellas County FL Special Guest: Laurel Rotter ,Pinellas County Elementary Math Supervisor THANK YOU,MIND RESEARCH INSTITUTE

COMMON CORE: The Transition in Pinellas County FL Special Guest: Laurel Rotter ,Pinellas County Elementary Math Supervisor THANK YOU,MIND RESEARCH INSTITUTE

MATH EDUCATIONNCTM Regional Conferenceswith NCTM president Linda Gojak and Louisville Regional Chair Sarah BushTHANK  YOU, MIND RESEARCH INSTITUTE  

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THE MIND RESEARCH INSTITUTE IS BRINGING A GUEST  USER FROM ANAHEIM, CA PUBLIC SCHOOLS TO SPEAK ABOUT HOW THESE INNOVATIVE , NEUROSCIENCE  BASED PROGRAM HOW MADE A TREMENDOUS DIFFERENCE IN THEIR SCHOOLS FOR A MULTITUDE OF STUDENTS.