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LinkedIn has officially opened its new campus at 4 Wilton Park, consolidating its Dublin operations into a modern, sustainable hub. This brings together LinkedIn's teams under one roof across 4 and 5 Wilton Park, with a combined footprint of 290,000 sq ft, making Dublin home to LinkedIn's largest office outside of the United States. The new campus is designed to support LinkedIn's evolving ways of working and foster collaboration among its 2,000+ employees in Ireland, who represent 60% of LinkedIn's EMEA workforce and over 70 nationalities. Speaking at the opening ceremony, An Taoiseach Micheál Martin TD said: "I'm delighted to open LinkedIn's new office at 4 Wilton Park. This expanded EMEA HQ - LinkedIn's largest office outside the US - is a strong endorsement of Ireland as a destination for global investment. "Over the past 15 years, LinkedIn Ireland has grown significantly, now employing over 2,000 people. This is a testament to Ireland's talented workforce and tech expertise." Building on this, LinkedIn CEO Ryan Roslansky added: "When we decided to put our EMEA headquarters in Dublin back in 2010, we started with three employees, and now we're more than 2,000 strong. "None of this would be possible without the support of the Irish government and the wider community. We're excited to continue shaping a brighter future of work together." Sustainability is at the core of the campus, which has been designed to operate at net-zero carbon, and is in the process of achieving LEED Platinum and WELL Platinum certifications, among the highest global standards for environmental performance and employee wellbeing. Sustainability is at the core of the campus, which has been designed to operate at net-zero carbon, and is in the process of achieving LEED Platinum and WELL Platinum certifications, among the highest global standards for environmental performance and employee wellbeing. The site features hydroponic gardens producing over 90kg of fresh ingredients per month, rooftop beehives, and a focus on locally sourced food. The project utilised responsibly sourced materials, such as those with recycled content, take-back programs, and bio-based materials Another key feature of the campus is the new LinkedIn Dublin Community Space, a free venue for local nonprofits to host events that help connect underserved communities to economic opportunity. Since launching in the previous building, the Community Space has hosted nearly 200 events for more than 300 organisations in the past year alone, welcoming over 10,000 attendees, with LinkedIn employees also volunteering their time and expertise to support these initiatives. Sue Duke, Head of LinkedIn Ireland, commented: "The opening of 4 Wilton Park, and the significant investment behind it, highlights the pivotal role our office plays in LinkedIn's global growth. "Our team in Dublin is central to delivering LinkedIn's vision of creating economic opportunity for everyone, whether that's developing AI tools to better connect jobseekers and employers or working with policymakers on future skills. " See more stories here.
For this episode of the Global Exchange podcast, Colin Robertson talks with Julian Lindley-French and Lord David Richards about their recent book, "The Retreat from Strategy: Britain's Dangerous Confusion of Interests with Values" and considerations for the Atlantic Charter. // Participants' bios - Julian Lindley-French is a CGAI Fellow and Chair of the Alphen Group and director of the Wilton Park the Future of War conferences. - David Richards is a member of the House of Lords and served as a professional soldier becoming General and Chief of the United Kingdom's Defence Staff. // Host bio: Colin Robertson is a former diplomat and Senior Advisor to the Canadian Global Affairs Institute, www.cgai.ca/colin_robertson // // Reading Recommendations: - "Churchill: Walking with Destiny", by Andrew Roberts: https://www.amazon.ca/Churchill-Andrew-Roberts-author/dp/1101980990 - "Roman Conquests: Britain", by Simon Elliott: https://www.amazon.ca/Roman-Conquests-Britain-Simon-Elliott/dp/1526765683 // Recording Date: February 14, 2025.
Rabbi Daniel Swartz, Spiritual Leader of Temple Hesed in Scranton, and Executive Director of the Coalition on the Environment & Jewish Life, speaking about the recent interfaith, climate-focused gathering in Italy under the aegis of Wilton Park, an Executive Agency of the UK Foreign, Commonwealth & Development Office, and the efforts to establish a lasting network to further work on behalf of the climate and environmental justice. www.coejl.org/
This episode, which coincides with the recent reopening of Wilton Park in Dublin, focusses on biodiversity and the important role that green spaces play in cities. Our CEO Niall Gaffney is joined by Robert Townshend of Townshend Landscape Architects and Tom O'Mahony from Maylim, both award-winning landscape companies. Hosted on Acast. See acast.com/privacy for more information.
Last week, Trinity College announced that the main library in its city centre campus has been renamed after Irish poet Eavan Boland. It will be the first building on Trinity's grounds to be named after a woman. This week, in more good news for Irish female writers, the Mary Lavin Place will also be publicly unveiled in Wilton Park, in Dublin's south side. It's a public plaza to commemorate the famous writer who lived nearby on Lad Lane with her three daughters. In today's episode, Róisín Ingle is joined by Lavin's granddaughter Kathleen MacMahon to talk about the writer's extraordinary life and what this commemoration means to the family. We're also joined by historian, lecturer, and Director of Gender Studies at UCD Mary McAuliffe who campaigned in 2013 for the Rosie Hackett bridge to be named after the Irish revolutionary activist. McAuliffe explains why so few Irish streets or spaces are named after women and what can be done to change this. Hosted on Acast. See acast.com/privacy for more information.
Dr Helen Fry has authored and edited over 25 books covering the social history of the Second World War, including British Intelligence and the secret war, espionage and spies, and MI9 escape and evasion. She is the foremost authority on the 'secret listeners' who worked at special eavesdropping sites operated by British Intelligence during WWII. Her groundbreaking research and extensive media coverage have shed light on one of the greatest intelligence deceptions of the war: the bugging of Hitler's generals at Trent Park in North London, and thousands of prisoners of war at Latimer House and Wilton Park in Buckinghamshire. Helen is the official biographer of MI6 spymaster, Colonel Thomas Joseph Kendrick. She has also extensively written about the 10,000 Germans who fought for Britain during WWII. Helen has appeared in a number of documentaries, including David Jason's Secret Service (Channel 5), Spying on Hitler's Army (Channel 4), and Secrets of the Spies (Britbox). She has covered the major D-Day commemorations in live BBC broadcasts from Normandy and is a recent recipient of the Lifetime Contribution Award for Jewish Military History and Education, awarded by The Jewish Military Association.Dr Helen Fry is guest number 388 on My Time Capsule and chats to Michael Fenton Stevens about the five things she'd like to put in a time capsule; four she'd like to preserve and one she'd like to bury and never have to think about again .For Helen Fry's books and everything else Helen, visit - www.helen-fry.comFollow Helen Fry on Twitter @DrHelenFry .Follow My Time Capsule on Twitter, Instagram & Facebook: @MyTCpod .Follow Michael Fenton Stevens on Twitter: @fentonstevens and Instagram @mikefentonstevens .Produced and edited by John Fenton-Stevens for Cast Off Productions .Music by Pass The Peas Music .Artwork by matthewboxall.com .This podcast is proud to be associated with the charity Viva! Providing theatrical opportunities for hundreds of young people . Get bonus episodes and ad-free listening by becoming a team member with Acast+! Your support will help us to keep making My Time Capsule. Join our team now! https://plus.acast.com/s/mytimecapsule. Hosted on Acast. See acast.com/privacy for more information.
Surfing the MASH Tsunami kicks off its 2023 wrap-up conversations with Jeff Lazarus, the 2023 winner of the Distinguished Scientific Achievement Award from the American Liver Foundation. He discusses three core MASLD-related opportunities for which he played a key role in 2023: the Research in Action initiative, the new MASLD nomenclature process and the Healthy Livers, Healthy Lives coalition.Most of this discussion focuses on Jeff's work leading the Research in Action coalition. As Jeff notes, this was the first time the MASLD "field has set its own agenda." Absent governmental or not-for-profit agencies driving the discussion, a group that has grown to over 400 collaborators published its own action agenda in AASLD and EASL publications. Jeff discusses the process through which he built this consensus, focusing on domains identified in earlier meetings: (i) treatment and care; (ii) models of care; (lll) increased awareness; and (iv) leadership. Jeff feels the legitimacy of this activity comes from "casting the net wide" with a series of Wilton Park meetings and from demonstrating how far MASLD lagged behind other non-communicable diseases in terms of goal development, structured support and public presence. Another key element in the initiative's success was a side event at the World Health Assembly led by the four major hepatology organizations, including not only AASLD and EASL but also APASL, and ALEH. Efforts to create parity with other non-communicable diseases will result in increased funding and "massive" increases in awareness.Today, the other NCDs mention other related metabolic diseases but not MASLD or MASH. Another example of the lack of urgency around MASLD: NIH just put out a call for funding for HIV, which Jeff notes might not be as high a priority in 2024 as MASLD.At this point, Jörn Schattenberg joins the conversation to congratulate Jeff on his recognition and award and also to discuss how important it is to the entire community that Jeff plays the role he does. In response, Jeff comments that one benefit of the Award is that it ratifies the importance of the kinds of consensus building and application of public health initiatives in MASLD space.From here, Jeff and Jörn step further forward to discuss the importance of funding prevention and education programs, done by governments in the EU and perhaps public or private players in the US. Jörn discusses the multidisciplinary nature of the Barcelona meeting they co-chair and how it provides outreach beyond hepatology. Jeff continues the thought to discuss the importance of social determinants of health (for example, food insecurity) in a world where healthy foods cost far more than more common alternatives (basmati rice costs 3x basic white rice).Roger asks how the new nomenclature is proceeding. Jeff says it is doing quite well in that there is significant global buy-in. Major centers around the world are adopting the new nomenclature for their meetings and clinics, but, Jeff notes, it is difficult for physicians to explain the disease to patients without using the words "fat" or "fatty."As the conversation winds up, Jeff notes the importance of bringing primary care to the education and outreach processes and the goal of doubling the number of patients screened over the next four years. The conversation closes on this note: much that must be done, but confidence that the energy to achieve these big goals is coalescing properly.
On this episode of The Global Exchange, Colin Robertson is joined by Julian Lindley-French and Lord David Richards about their recent Wilton Park report, The Future War: Strategy and Technology. You can find this report here: https://www.wiltonpark.org.uk/event/future-war-strategy-and-technology-conference/ Participants' bios - Julian Lindley-French is a CGAI Fellow, Chair of the Alphen Group and director of the Wilton Park the Future of War conferences - Lord David Richards is a member of the House of Lords and a former General and Chief of the United Kingdom's Defence Staff. He is president of the Wilton Park the Future of War conferences. Host bio: Colin Robertson is a former diplomat and Senior Advisor to the Canadian Global Affairs Institute, www.cgai.ca/colin_robertson Read & Watch: - "Politics On the Edge", by Rory Stewart: https://www.amazon.com/Politics-Edge-host-podcast-Rest-ebook/dp/B0BXGNMXFK - "Major and Mrs. Holt's Battlefield Guide to the Somme", by Tonie and Valmal Holt: https://www.amazon.com/MAJOR-HOLTS-BATTLEFIELD-GUIDE-SOMME/dp/0850524148 - "The Savage Storm: The Battle for Italy 1943", by James Holland: https://www.amazon.ca/Savage-Storm-Battle-Italy-1943/dp/080216160X - "Blott on the Landscape", by Tom Sharpe: https://www.amazon.ca/Blott-Landscape-Tom-Sharpe/dp/0099435470 - "A World Restored: Metternich, Castlereagh and the Problems of Peace, 1812-22", by Henry Kissinger: https://www.amazon.ca/World-Restored-Metternich-Castlereagh-Problems/dp/1626549788 Recording Date: December 4, 2023. Give 'The Global Exchange' a review on Apple Podcasts! Follow the Canadian Global Affairs Institute on Facebook, Instagram, Twitter (@CAGlobalAffairs) and Linkedin. Head over to our website www.cgai.ca for more commentary. Produced by Joe Calnan. Music credits to Drew Phillips.
In October 2023, an expert group of national security experts from around the world came together at Wilton Park in Sussex for a discussion and exchange of views on the role of technology in future war, and the strategies that Western states needed to adopt in order to mitigate the impacts, to improve their own credibility, and make adversaries think twice. The conference convener, Professor Julian Lindley-French joins Peter to talk through some of the findings.
How have cyber conflicts played out between Russia and Ukraine? Over the last decade the idea of cyber war had been widely hailed as a horse/tank moment in warfare, perhaps more even: speeches were made about the cyber domain would have the ability to determine the future of battlefields, and to make armies, air forces and navies irrelevant. And Russia has always been noted to be be a Tier One cyber state, whereas Ukraine wasn't - certainly in February 2022. Peter talks to Rob Black at Wilton Park about how the cyber war played out over the first year of Russia's war on Ukraine - and why it failed to deliver what the cyber acolites promised. While political and military leaders have placed huge emphasis on the silver bullets that were supposed to be cyber weapons, the reality in Ukraine seems to have demonstrated something very different. The Gartner Hype curve of technology seems to have some home to roost.
In the Season 3 NAFLD Year-in-Review conversations series, Surfers Jörn Schattenberg, Louise Campbell and Roger Green embark on a string of interviews with a handful of Key Opinion Leaders who made headlines and advances in Fatty Liver disease in 2022. In this exclusive segment, Jeff Lazarus opens in full disclosure admitting that, overall, 2022 has been a tough year in health care as “everyone is overwhelmed” while we all try to emerge from the pandemic. Regarding the status of Fatty Disease, Jeff is more optimistic as this year witnessed movement outside of hepatology into the space of diabetes societies and primary care meetings. Such collaborative energy is needed “to understand the metabolic syndrome and not just silos.” Jeff goes on to cite a return to an in-person Wilton Park meeting as an example turning point for such synergies.The conversation evolves to consider targets, goals, endpoints and some small distinctions between each in the framework of public health. Jeff notes that we will need what he describes as a “drugs-plus approach” to address Fatty Liver disease - similar to that vaccines were not the single defense in combating the COVID pandemic. While drug therapies may be the cornerstone for fatty liver disease, there remains the need for lifestyle interventions through diet and exercise. As Jeff indicates, this mission is larger than hepatology alone. While a wider net of stakeholders establish clinical care guidelines in the context of professional societies, there still lacks, in example, a technical strategy coming from an organization such as the W.H.O. Jeff believes establishing work around the Sustainable Development Goals is important in showing the connection between different targets and the liver. He extends this idea to connect socioeconomic variables to liver health outcomes.The group also explores the idea that when drugs become available to market, treater interest picks up because there is encouragement from the fact that something that can be done. Jeff hopes this positive energy will also recruit more resources in the form of nutritionists and dieticians. He raises questions around imagining what new models of care look like, and how do we improve communications and teamwork. His response: the availability of drugs and the imminent availability of drugs will set fire to the changes that will need to follow. He adds comments on the importance of addressing the policy arena and ensuring policymakers and health authorities are aware of the potentially deadly, highly prevalent condition. They need to be aware that there are soon to be approved and available drugs, and that the majority of this population is undiagnosed. Jeff further reasons that Fatty Liver is in need of a more proactive approach that identifies and educates on the risks of disease progression before advanced fibrosis takes hold. As the conversation winds down, the group investigates the implications and process behind ongoing discussion on nomenclature.
Roger starts by asking Jeff to describe his role in the NAFLD Summit and to discuss any other presentations of interest outside of his own. Jeff shares that he will be talking about evolving models of care and future implications. His interest in the session stems not just from his presenting, but from the session title, "Epidemiology, Disease Modifiers and Models of Care," and the opportunity it presents to, as Jeff puts it, "hammer home" the importance of integrated care and pathways. He also mentions the importance of the sessions covering NITs, which are pivotal to the way forward, new approaches to lifestyle modification and drug clinical trials and development. The conversation shifts Jeff's other activity in Dublin: meeting with industry and other colleagues to build momentum for an upcoming meeting at Wilton Park to build on the momentum of the 2021 global consensus statement on NAFLD. (This was the topic of Season 2, Episode 59.) The conversation veers into two other topics of relevance. First, Jeff draws a link between the importance of viewing liver disease in a truly multi-disciplinary context with the broadening of presentation topics at major meetings. He points out that if we want colleagues from other medical specialties to join in efforts to contain the coming NAFLD pandemic, medical meeting agendas must include enough topics of interest to them to broaden the prospective set of attendees. The second issue involves engaging the WHO to incorporate liver disease into its global health priorities.
The 8th Paris NASH Meeting takes place on September 8th & 9th, where key opinion leaders from both sides of the Atlantic come together to present pivotal learnings and host exciting discussions on fatty liver diseases. Surfers Roger Green, Louise Campbell, and Jörn Schattenberg are joined by Rachel Zayas to discuss this year's program and provide preview commentary on talks and sessions of interest.Roger opens the floor by asking everyone to highlight what specifically stands out to them on the program to look forward to. “Brave one go first.”Rachel notes a presentation in Session 2: Clinical Aspects, titled Controversy: are HIV infected patients more at risk of NASH? Emerging data and insights will be discussed as to why the prevalence of NAFLD, NASH and subsequently fibrosis present higher in HIV-infected patients in comparison to the general population. Rachel hopes the prompt leads to speculation on how to improve patient stratification. She suggests the field is moving beyond ideas of personalized medicine to what is described as a more intentional approach. Jörn echoes Rachel's interest in this topic. There is the need to address not only individuals, but also a group of overlooked patients that call for an intentional and stratified investigation into potentially shared biomarkers. Session 2 also features a discussion on type 2 diabetes sub-populations with varying outcome profiles, solidifying the Clinical Aspects leg as a ‘can't miss' for the whole group.Next, Louise calls attention to the opening session and her interest in the integration of the liver under cardiometabolic health. “That's where we're going to find the breadth and depth of patients for future NASH studies.” She asserts that a larger recruitment to clinical trials will be required in the next 3 to 5 years to move the field forward.Roger relates the relevance of last week's episode on finding the right combinations for NASH therapy. Friday afternoon features a look into the current status and future directions in NIT-based drug development and clinical management of NASH.The conversation shifts to comparative outcomes of the Barcelona meeting and its focus on pathways before transitioning into part 2 of this episode: a one on one interview with Prof. Jeff Lazarus. Much of Jeff's summer was spent working in preparation for the impact COVID will have on the northern hemisphere this autumn. However, he also managed to attend the NAFLD Nomenclature Conference in Chicago. The conference is described as a midway point for a Delphi process that explores the prospect of assigning a new name(s) in the description of fatty liver diseases. What was determined is that should a name change occur, it needs to be organized through global consensus and consistent with the following 6 principles:AffirmativeAccurateAdaptableAdoptableApplicableAbleRoger believes that the meeting was successful at strengthening consensus on this topic. He then asks Jeff to describe his role in the NAFLD Summit and to mention any other presentations of interest outside of his own. Jeff shares that he will be talking about evolving models of care and future implications. Specifically, he is also interested in attending discussions and panels around the impact of NITs in addition to the topic of personalized medicine. Likewise, Roger expresses an interest in emerging technologies before offering a final question - or, rather, a request for commitment. Will Jeff return to the podcast to disclose what occurred at the Wilton Park meeting this October? It seems he might, after a few weeks digestion. Stay tuned, stay safe and surf on.
Moe Dunford stars in Nightride, about a drug dealer desperate to go straight. The Woman in White Joanna Hiffernan and James McNeill Whistler, an exhibition running at the Royal Academy in London. Living Canvas, digital art at Dublin's Wilton Park.
This conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Professor Jeffrey Lazarus of ISGlobal and the University of Barcelona joins Louise Campbell and Roger Green to discuss the emerging NAFLD public health agenda. Jeff Lazarus comes to the effort to create a global NAFLD Public Health agenda from his experiences spearheading similar efforts in HIV and Hepatitis C. The conversation begins with Jeff describing the path by which he shifted focus from each liver disease to the next. Just as reduction in HIV transition rates revealed the high level of Hepatitis C infections among HIV patients (particularly intravenous drug users), the reduction in Hepatitis C incidence following advent of the direct-acting antivirals revealed still-significant levels and growth rates of liver cirrhosis. This in turn revealed the degree to which NASH is driving the continuing growth of cirrhosis in the global population. It also revealed the degree to which efforts to reduce or eliminate NAFLD were lacking a strategy, an idea of the burden or sense of economic consequences. From here, the discussion shifts to looking at similarities and differences between HIV and Fatty Liver Disease. One key similarity: a patient can have this disease for a long time before having to address it. A key difference: the steps one takes to combat infectious disease vs. what is more of a "lifestyle" disease.Next, the group discussed Jeff's path to help shape a global consensus around the need to treat Fatty Liver and an action plan regarding how to do so. The first key was to determine how many countries are prepared to deal with NAFLD. Answer: out of 102 the group explored, none were prepared. This led to a two-year process with 218 global stakeholders to develop a global consensus statement on goals and actions, which we discussed on S2 E59. With these pieces in place, the global stakeholder group is working on a framework of sustainable development goals.In response to a question from Louise regarding the impact of COVID-19 on these efforts, Jeff stated public leaders have not and will not educate the public on the impact of diet and exercise on the disease.. As a result, NAFLD Public Health advocates need to educate leaders on why public safety and nutritious diets are goals for fighting Fatty Liver. NOTE: It emerges that the countries with the best public preparedness for NAFLD are those that take guidance from hepatologists.In response to a question from Roger, Jeff suggested the attitude that bad health behavior is an individual right but paying the costs of the result disease is a social cost is not new. Specifically, he noted that this attitude is not different from what we see with tobacco or alcohol. He went on to discuss the importance of promoting public health, not only as a way to improve individual behaviors but also to create and focus advocates. Today, he states, we are failing both to diagnose the disease earlier and to invigorate providers, patients and social actors to behave in ways that reduce the rate and severity of what is in many ways a lifestyle disease.A comment by Roger about the relationship between urgency and action leads Jeff to discuss the "terribly unsexy"attribution fraction, a statistical analysis that estimates the percentage of severe liver outcomes that are attributable to a specific disease (for example, NAFLD vs. Hep C.)As the conversation closed, Jeff discussed his priorities for 2022: (i) to create and work with partnerships to take actions that give life and substance to the consensus recommendations; and (b) to create more consensus opportunities around the work of Wilton Park and possibly a similar meeting in the Americas.
This conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Co-host Dr. Stephen Harrison joins Louise Campbell and Roger Green to review five key NASH themes that emerged in 2021, while simultaneously discussing the year for Surfing the NASH Tsunami.It seems fitting that the first SurfingNASH event of 2022 should include Stephen, Louise and Roger. In this thoughtful, fast-moving conversation, Stephen identifies what he considers five key areas where the Fatty Liver community has progressed in the past year:1. Call to action -- 2021 saw two separate, vitally important calls to action to share the scope of the upcoming NASH pandemic with the medical community at large and begin to create forums and processes to develop an agenda and care practices that would reach far beyond hepatolotgy all the way to primary care and other specialties that have historically had little to do with the liver. Jeff Lazarus work with colleagues at Wilton Park and in over 100 countries to evaluate the current status of NASH diagnosis, treatment and screening around the world and to being developing a public health agenda. At around the same time, a multidisciplinary panel of US opinion leaders organized by AGA published a general call to action and a specific Clinical Care Pathway, starting at diagnosis, that included multiple specialties and, for the first time, set out to define a way specialties can work together in identifying patients at risk, screening them for disease, and then treating as appropriate.2. Natural History -- 2021 saw publication of two major papers on the natural history and progression of the disease. One paper produced by Stephen, Naim Alkhouri and a range of associates, evaluated a large group of seemingly healthy middle-aged men who receive treatment at the San Antonio Military Medical Center and mirrored a smaller study 10 years earlier. The two studies were fairly consistent in determining that slightly over one adult in three has demonstrable NAFLD and one in seven or eight has documentable NASH. The difference in the populations was that while approximately 2% of the 2011 sample exhibited F2 or F3 NASH, that number almost tripled ten years later. These papers and Dr. Arun Sanyal's work published later in the year in the New England Journal of Medicine indicated that we can project a steadily increasing trend line for cirrhosis cases, with growth in most major markets at 10-12% per year.3. Drug Development --news here was mixed, although Stephen points out that we have learned from each failed trial. SurfingNASH discusses this topic frequently, so suffice it to say that as the year ends, three medications recruiting or conducting Phase III trials and several other exciting, innovative agents have already demonstrated some positive Phase II results.4. Weight loss surgery -- Stephen feels that the SPLENDOR study, which we discussed recently on the podcast (S2 E60), merits notice because of what it suggests about the ability of dramatic weight loss to halt or reverse cirrhosis. There are drugs in development right now that appear capable of producing the same levels of weight loss shown with bariatric surgery, which provides hope that we can eventually stabilize and perhaps regress fibrosis levels in cirrhotic patients.5. Non-invasive testing -- Several different modes of non-invasive testing have made progress during the year, ranging from liquid tests that received FDA approval and/or enhanced their commercialization capabilities to published research suggesting that MR Elastography (MRE) has compiled much of the data necessary to prove outcomes with greater clarity and confidence than biopsy. Stephen shared his belief that 2022 will be the year when academics, drug developers and regulators begin to align around a strategy to move beyond biopsy with deliberate speed.None of these items are new, but the way Stephen organizes them is clearly worth a long listen.
This conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Professor Kenneth Cusi of the University of Florida joins Louise Campbell and Roger Green to discuss the NASH multidisciplinary initiative organized under the aegis of AGA the resulting paper of Clinical Care Pathways.In 2021, Ken Cusi played an integral role in the NASH Multidisciplinary initiative fostered under the aegis of the American Gastroenterological Association (AGA) and leading to the paper "Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease," originally published in "Gastroenterology". This conversation begins with Ken mentioning some of the motivations and sources that led to the creation of the multidisciplinary group behind the Clinical Care Pathway paper and the earlier "Preparing for the NASH Epidemic: A Call to Action." Ken starts this conversation by discussing the momentum that is building around taking a disciplined, multidisciplinary approach to the emerging NASH pandemic. He cites recent US publications based on the NHANES database and work done in Europe by Jeff Lazarus and Wilton Park as being major driving forces. The discussion moves on to Ken's prediction that 2022 will be a "great year" based on new or updated guidelines from AASLD, AACE and the American Diabetes Association plus Phase 3 studies coming forward for semaglutide, lanifibranor and resmetirom. Louise Campbell notes that not only are medical groups collaborating, but in the UK, food companies have requested more robust food labeling guidelines from the government there. Ken goes on to predict "a convergence of awareness" around the clinical care pathway and using FIB-4 as a first stage test. He notes that ELF and ProC3 will become commercially available, which will augment testing capabilities and goes on to discuss some larger studies taking place to better define risk for different elements of the population. Louise Campbell asks what is likely to change over the next 2-3 years, at which point Ken discusses the increasing momentum he believes will lead to more testing, increased data generation and studies and a broader awareness of the role the liver plays in overall metabolic health. Roger asks how the new testing and patient vigilance will fit into an already overcrowded patient visit workload. Ken suggests that placing FIB-4 results and guidance on electronic medical records will increase primary care awareness and action by itself. This energy is offset somewhat by a lack of compensation for primary care and endocrinologists who identify patients with cirrhosis and also by the emotional exhaustion of treating patients through the COVID-19 pandemic. From here, the group goes on to discuss the processes through which screening and diagnosis are likely to become more widespread and treatment will become better integrated. In the end, Ken discusses the reasons he is highly optimistic about where the entire NASH field is heading in the years to come.
Lead author Jeffrey Lazarus joins the Surfers to discuss Advancing the Global Public Health Agenda for NAFLD, the major article recently published in Nature Reviews Gastroenterology and Hepatology. The article reports the results of a study with 218 Fatty Liver stakeholders in over 95 countries. Jörn Schattenberg, who participated in the entire exercise, joins Stephen Harrison, Louise Campbell and Roger Green to discuss the process, the insights and what comes next.8:55 - Jeff Lazarus begins discussion by discussing Delphi process and scope 13:13 – Jeff reports: No country scored over 50 on preparedness for the NAFLD pandemic and goes on to list the eight core issue areas for this initiative14:49 – Jörn Schattenberg discusses his reactions as a participant in the process16:29 - Stephen Harrison says clinicians will support document, then goes on to describe how healthcare practices in the US militate against thoughtful patient care18:45 – Stephen's wish: more data so we can provide stronger insights on prevalence19:55 – Jörn elaborates on how an agreed public health agenda and care models could streamline diagnostic and treatment processes20:35 – Jeff: we are a long way from strong global data…and we need that data to demonstrate the current and future cost of disease to policymakers22:22 – Stephen: we know enough today to target post-menopausal females with marginally controlled diabetes23:25 – Louise Campbell sees various systems' weaknesses and strengths as source for planning25:01 – Louise: “I can't fathom” the potential cost savings of earlier screening and treatment 25:45 – Jeff discusses his Hepatitis C experience to say “This is how we start”26:21 – Roger Green comments the dual awareness challenge: physicians do not think of NASH as even one disease when in fact it is two: a metabolic NCD in F2 vs. serious liver disease in F428:13 – Jeff describes the strong positive reaction of the Nature Reviews journals and others toward this paper29:15 – Jörn: this kind of awareness will help us raise public and not-for-profit funding for related research initiatives29:50 – Discussion shifts to “What comes next?”30:01 – Jeff discusses ways the collaboration continues and notes that the liver community needs allies to make this happen34:36 – Stephen: we need one messages to motivate patients to improve behavior and another to compel governments to spend 36:07 – Jeff: we need governmental structures to support individual activities36:20 – Louise: we need to increase education and focus on small behavioral steps people can achieve40:11 – Stephen's key place for impact: a simple global message for frontline providers that looks forward to when NITs become accepted and drugs are available42:44 – Roger asks how this effort relates to the US multi-specialty Clinical Care Pathways initiative 44:06 – Jeff: Clinical Care Pathways excellent, but we still need to focus on national health systems, sedentary lifestyle and patient education45:37 – Jeff: Center for Disease Analysis forecasts a 2x – 4x growth in NASH cirrhosis between now and 2030 in the countries they have modeled46:12 – Louise doubts our health systems can handle that kind of growth 47:48 – Jeff: cirrhosis will “sneak up” on global health authorities49:49 – Final question: one place we can have impact quickly50:02 – Jörn: working with policy makers in Germany to develop a national strategy50:26 – Louise: educating policy makers in the UK 51:18 – Roger: develop a message that conveys the "two disease" idea52:05 – Jeff: longer term modeling to demonstrate scale of problem53:10 – Roger asks, if incidence estimates are too high, will anticipated costs scare off US and other payers54:11 – Jeff sees overestimation as a potential problem56:03 – Business section
Welcome to the Genius Design Transcends Time Podcast: Where Fashion and Health Connect. Our guest today is Mrs. Anne Bader, a woman who is a symbol of timeless elegance for over 30 years and revered for her skill and influence in building bridges between diverse stakeholders to achieve agreement on moving closer to sustainable peace. Anne is known amongst her peers for her tremendous work behind The Iron Curtain after its fall with peace keeping initiatives and today in her active cybersecurity news. In today’s episode Anne Bader and Andrea Alexa Smith talks about fashion as a visible anchor to hope, beauty, and harmony of our world. Anne shares her advice for young independent women, including our shared risk, speaking up when you need help, being comfortable and confident in your clothes and knowing what you want. Anne is the founder of International Cybersecurity Dialogue, dedicated to bridging the gap between policy makers and security technologists in government, business and academic spheres. This unique round table allows leaders seeking peer level debate and exchange by invitation and off the record as appropriate to allow participants-all current public and private experts-the freedom to voice their individual ideas and opinions adding value to this collaborative network. Experts discuss topics such as Information Sharing, Norms, Best Practices and Law, Critical Infrastructure Resilience, Responsibility and Accountability, Supply Chain Assurance and Threats: including anticipation, deterrence, mitigation, and response to better manage threats and opportunities. Anne’s recent work includes being a US government speaker at Infofest, a regional cyber conference in Montenegro, in tandem with the US State Department Cyber Speaker Tour of Serbia. Previous programs include the Resilience to Crises Programme with the Defence Academy of the United Kingdom in partnership with NATO in Prague, Belgrade, Paris and London; TRUST, (Together Reducing Unsafe Tools of War) in Ukraine, Albania, Serbia, Belgium and the United States to promote good governance and defense reform through the Partnership for Peace Trust Fund; and the Partnership for Peace (PFP) NGO network throughout countries of the former Soviet Union with the Special Advisor, Secretary General NATO.Previously, Mrs. Bader served as Senior Research Fellow and Director, Advanced Research Assessment Group, The Defence Academy of The United Kingdom; Visiting Programme Director, Wilton Park; Executive Vice President, The Fund for Peace; Vice President, the Atlantic Council of the United States; Vice President, Trinity College and Vice President, Business Executives for National Security all of Washington DC.Mrs. Bader is a graduate of Trinity University Washington and Georgetown Visitation Preparatory School of Washington DC. Her memberships include the National Press Club, Women in International Security and the Board of the Hungarian American Coalition.https://cybersecuritydialogue.org
Z/Yen conducts an irregular series of short webinars, CommunityZ Chest, featuring people from its various communities and clubs, viz. technology, financial services, civil society, and business. These webinars provide an opportunity to meet people from the wider CommunityZ, to share ideas, and to make connections. This CommunityZ Chest features Richard Burge. Richard has been the chief executive of the London Chamber of Commerce and Industry since February 2020. He has led four multi-million pound organisations as chief executive over a total of 18 years. They ranged from a famous charity to a UK government agency to a private company to a membership body. All of them were revenue-based operations delivering public benefits. He has been on the Board and a non-executive chair/director of five multi-million pound operations including companies, charities, two government agencies, and a UK Russell Group university. Richard has worked in over 55 countries, specialising in Africa, the wider Commonwealth, and post-conflict situations. He was Chief Executive, Commonwealth Enterprise and Investment Council from 2017 to 2019. For the previous 8 years, he was Chief Executive of Wilton Park (a Foreign and Commonwealth Office agency for conciliation and dialogue on global issues). He was a Commissioner for Commonwealth Scholarships, and on the Council of Durham University He has been CEO of the Countryside Alliance, Director General of the Zoological Society of London, and for ten years served with the British Council in Africa and the Middle East. Interested in watching our webinars live, or taking part in the production of our research? Join our community at: https://bit.ly/3sXPpb5
Gisela Stuart is a rare figure in British politics - a Labour politician who campaigned wholeheartedly for Brexit.As an MP from 1997-2017, Gisela is perhaps best known for her role in the 2016 referendum, where she chaired the Vote Leave campaign and appeared in the TV debates. But her deep interest in constitutional and foreign affairs long-predates that referendum. Gisela sat on the Foreign Affairs Select Committee for nearly a decade, was a founding signatory to the foreign policy think tank The Henry Jackson Society, and is now Chair of Wilton Park, an executive agency of the Foreign Office dedicated to mediation and resolving international conflict. Our Assistant Editor, Frank Lawton, sat down with her to chat all things foreign affairs. See acast.com/privacy for privacy and opt-out information.
We live in a globalised world. Just as people, goods and services cross borders, so do the impacts of climate change and our subsequent adaptation responses. A localised drought, occurring more frequently and intensely as a result of climate change, disrupts a global supply chain, which in turn affects consumers many thousands of miles away. An adaptation response, to increase irrigation by tapping a transboundary river, affects a shared ecosystem and shifts sensitive political dynamics across a region. The stakes are high, yet our current adaptation plans often fail to recognise or account for such transboundary risks or our global interdependence. Ahead of the UN Climate Action Summit 2019, ODI and Wilton Park convene a high-level discussion to present new research on transboundary climate risk. Together with our partners, SEI and IDDRI, we are also launching a new initiative–Adaptation without borders–to harness the international cooperation needed to effectively govern and manage such risks. We explore how we can raise visibility of transboundary climate risks, gather evidence and analysis, build connections between stakeholders and drive action from both policy-makers and practitioners, to ultimately reposition adaptation as a global public good. We cannot afford to wait. The last four years were the hottest on record. Winter temperatures in the Arctic have risen by 3°C since 1990. As governments grapple with the adaptation actions required today and tomorrow, we must complement local action with enhanced multilateral cooperation–'adaptation without borders’ is a global imperative.
Access to the right data can be as valuable in humanitarian crises as water or medical care, but it can also be dangerous. Misused or in the wrong hands, the same information can put already vulnerable people at further risk. Kenneth Cukier hosts this special edition of Babbage examining how humanitarian organisations use data and what they can learn from the profit-making tech industry. This episode was recorded live from Wilton Park, in collaboration with the United Nations OCHA Centre for Humanitarian Data See acast.com/privacy for privacy and opt-out information.
Access to the right data can be as valuable in humanitarian crises as water or medical care, but it can also be dangerous. Misused or in the wrong hands, the same information can put already vulnerable people at further risk. Kenneth Cukier hosts this special edition of Babbage examining how humanitarian organisations use data and what they can learn from the profit-making tech industry. This episode was recorded live from Wilton Park, in collaboration with the United Nations OCHA Centre for Humanitarian Data See acast.com/privacy for privacy and opt-out information.
Each week I invite one of my speakers to talk about their life, work, passions and leisure so that you can get to know the person who is the speaker behind the mic. This week we talk about how the Americans and the British do business very differently. We discover the mistakes businesses make when entering the US market and what leaders should be doing to build their personal brands. My guest this week is advisor, author, broadcaster and entrepreneur - Allyson Stewart-Allen. Allyson has advised over 200 businesses in 26 countries on how to successfully avoid the minefields of international expansion. She has authored the best-selling book Working with Americans, and is a regular media commentator for the BBC, CNN and the FT. Bio Allyson Stewart-Allen is a renowned marketer, whose expertise in brand internationalisation is sought by leading businesses globally through her consultancy, publications, appearances, mentoring and corporate education. A Californian based in Europe for over 25 years, Allyson applies her extensive international consulting experience, MBA education with Dr. Peter Drucker and languages (French, German) to the company she founded, International Marketing Partners. Having recognised the need for international brands to better align their global and local marketing practices, Allyson Stewart-Allen created the BrandBarometer™ powered by Seattle-based GMI (Global Market Insite), which surveyed a worldwide panel of over 17,000 consumers across 17 countries on their perceptions and direct experiences of the world's most recognised brands. Using the BrandTravel™ methodology, Allyson helps companies and their leaders to successfully and profitably span international and functional boundaries by giving them the tools to be more effective in a global arena. The benefits clients enjoy as a result include better localisation, increased corporate diplomacy capability and more effective relationships with internal and external stakeholders. Allyson is engaged for her award-winning corporate education experience by both Fortune 500 companies and the world’s leading business schools including Oxford University, London Business School, HEC Paris, Duke Corporate Education amongst others. Following her early career with blue-chip consulting firms PwC, PA Consulting Group and Hay Management Consultants, Allyson now advises executives and Boards of Directors in the professional services (legal, property, financial and retail), food & drink, travel, consumer goods and industrial sectors to name a few. Her work with clients enables them to lead and manage across cultures, achieve their marketing and business development strategies through successful strategic alliances/joint ventures, organic growth and/or acquisitions. Allyson Stewart-Allen is co-author of the best-selling book Working with Americans, the first business manual exclusively about the US business culture, which helps professionals improve their relationships with, and profits from, American business partners, bosses and colleagues. Allyson is recognised in The Female FTSE Report 2014:100 Women to Watch list produced by Cranfield’s International Centre for Women Business Leaders as well as being listed in Who’s Who in the World, Who’s Who in America and Who’s Who Among Women. Allyson is a frequent keynote speaker at conferences including The Conference Board, Wilton Park, Economist Conferences, Institute of Directors Conferences, British American Chamber of Commerce, Marketing Society and the American Marketing Association on a variety of global marketing trends and developments. An experienced and frequent commentator, she lends her insights to broadcast, print and digital media across the globe. Besides her 4-year slot for Sky News as The Muse of Marketing, she has appeared on several television shows including CNBC’s The Business Class and the past three seasons of BBC’s The Apprentice. Other outlets applying her insights include BBC News, ITV News, CNN, The Financial Times, Bloomberg, USA Today, Business Week, The Wall Street Journal, Newsweek and Fortune magazines. In addition to her role as a Board member of the Chartered Institute of Marketing, she is a judge for numerous international business awards on both sides of the Atlantic. Recorded: 15th January 2019 Links: More about Allyson Stewart-Allen More about Maria Franzoni Ltd Connect with Maria on Linkedin Connect with Maria on FaceBook To book any of the speakers featured on the Speaking Business podcast, click here
Recorded a week after Trump's Inauguration, this week's episode is with Richard Burge, Chief Executive of Wilton Park - an executive agency of the Foreign Office who helps coordinate Global political discussions - about the diplomacy of science. We chat chemical weapons, bioterrorism and nuclear treaties; we discuss why there are historians and classicists in policy but so few scientists; and how we ensure those who are making International decisions are clued up on the latest discoveries and advancements. This one's a goody...