Podcasts about MP

Renue Healthcare https://Renue.Healthcare/ToddYour journey to a better life starts at Renue Healthcare. Visit https://Renue.Healthcare/Todd Bulwark Capital https://KnowYourRiskPodcast.comBe confident in your portfolio with Bulwark! Schedule your free Know Your Risk Portfolio review. Go to KnowYourRiskPodcast.com today. Alan's Soaps https://www.AlansArtisanSoaps.comUse coupon code TODD to save an additional 10% off the bundle price.Bonefrog https://BonefrogCoffee.com/ToddGet the new limited release, The Sisterhood, created to honor the extraordinary women behind the heroes.   Use code TODD at checkout to receive 10% off your first purchase and 15% on subscriptions.LISTEN and SUBSCRIBE at:The Todd Herman Show - Podcast - Apple PodcastsThe Todd Herman Show | Podcast on SpotifyWATCH and SUBSCRIBE at: Todd Herman - The Todd Herman Show - YouTubeJeffrey Epstein and a Comet Ping-Pong Movie? // Raged and Refused: Satan's Plan for Gen-Z // Jesus = Hate SpeechEpisode Links:Island. Pizza. Young women. Predator. You can't make this up... James Alefantis, owner of Comet Ping Pong, implicated in PizzaGate as a member of the trafficking cult is credited as the executive producer of an indie film called AUTOMATIC AT SEA by Matthew Lessner and this is the description:Automatic at Sea': Why the Hyperreal Film 'Represents the Horror of Being Alive Right Now' Matthew Lessner's stylish thriller 'Automatic at Sea' challenges perceptions of reality.2023. Reid Hoffman explains why he funded E. Jean Carroll's lawsuit against Trump. Hoffman, the walking embodiment of perversion, a man who stayed at Epstein's ranch, island, and NYC home and sent Epstein gifts for "the girls," claims he funded the lawsuit to help Carroll get justice for the "torture" and sexual abuse she endured. Hoffman just wanted to help a woman stand up to a rich and powerfulGiving cross sex hormones and SSRI's to mentally ill people is proving to be a colossal mistake that will end up paying divendends in death and destruction. Believe detransitioners and share their stories, it's the only way this madness will end.Democrats in Oregon have killed a proposed bill that would have outlawed giving out drug paraphernalia like needles and pipes within 2,000 feet of a school or childcare center. Militant far-left groups linked to Antifa have been doing so for years.For today's teens, there's no such thing as dating without sex. He's a father at 13 years-old.Our Whiteness is part of the problem of meat eating” “Hamburger comes with a dose of misogyny” “The notion the best protein comes from corpses, is a racist belief” “Meat eating is also one of the ways gender based oppression is perpetuated”THIS IS ABSOLUTE INSANITY. Päivi Räsänen, MP in Finland has been dragged through the courts for 6 YEARS because she tweeted a Bible verse. She was acquitted twice but prosecutors won't drop it

How do you handle an MP who goes rogue from his own party?  That's a question for this week's Moore Butts conversation.  But first, Gerry Butts on the world's new security order.  Gerry has just returned from the Munich Security Conference and the former principal secretary to Justin Trudeau, and former Stephen Harper cabinet minister James Moore discuss how Canada can fit into the new Europe versus the US picture. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Roy L Hales/ Cortes Currents - Our local MP, Aaron Gunn, is holding a series of town hall meetings in the North-Island Powell River riding. He will be in Courtenay tonight (Feb 17), Campbell River on February 21, Port McNeil on March 16 and Powell River on March 19.  Gunn may also come to Cortes Island, but the dates have not been set.  Aaron Gunn: " We want to come to Cortes, but if I just come to Cortes with no plan - I haven't really accomplished anything other than a photo op. So we always try to set up some kind of coffee or meeting where people that live there know that I'm coming and if they want to come and engage, they have an opportunity to do so." Cortes Currents: We will promote it on the radio. We will promote it over our bulletin board. It's called the Tideline. The size of the crowd's hard to tell, could be as few as 20, or as many as 100. The hundred would be surprising, but who knows? We haven't had a Conservative candidate or politician on the island for years. Aaron Gunn: It's always better to have more people show up, but the most important thing from my perspective is you give everyone an opportunity to come out and voice their opinions and ask their questions. Different communities certainly have different amounts of political engagement. Power River has an incredible amount of engagement for the size of its community.We'll see how the Comox Valley goes tomorrow, but of course only half of the valley's in my riding. So a bunch of people who I'm not representing might show up at the door, but that's okay." While the Conservative party saw increased support on Cortes during the last election, Gunn will face a variety of perspectives.  Max Thaysen, the alternate director for Cortes Island and co-leader of the Cortes Climate Action Network, responded, "I welcome him to come and I will be happy to ask him some questions, find out more about what he thinks about some really important stuff. I think having open and public dialogue with people who've been elected to the House of Commons is very important. There were some early concerns that Aaron Gunn was not interested in hearing from constituents. That was something that I heard in a few different places from people who were trying to get hold of him to share their concerns with him. I think he's become more open to hearing from people and sharing with them. That's a good thing." "I also want to say that, as a very climate concerned person, I am very concerned about the public position that the Conservative party has taken. It borders on climate denial and that is very dangerous. I think we'll have some pretty serious conversations to have. I hope we get lots of people out. It should be fun. Come bring your own questions." Cortes Currents asked Gunn what he hoped to achieve through his town hall meetings. Aaron Gunn: "The primary vision is to give constituents an opportunity to hear directly from me and ask any questions that might be on their mind. We get hundreds of emails every week and try to meet with as many constituents as possible, but this is a very efficient and transparent way to engage with the people that you're representing and give them a chance to hold you accountable."

Chris Hipkins says we need to take the politics out of the Infrastructure Commissions National Infrastructure Plan. The Leader of the Opposition told John MacDonald that he thinks the Commission has done a "really good job" on their recent report, and we need to focus on the basics. "They've pointed out we have an over reliance on shiny new things, and we haven't done the basic maintenance of the things we've already got." "We need to take the politics out of it and focus on a long-term plan." On the rise of Winson Peters and NZ First in the polls, he said that Peter's lifetime in politics has given some unique political skills of reinvention. "At the moment, he's trying to be an opposition MP while also trying to be the third highest ranking minster in the current government." When asked if he has considered working with Peters to form the next government, Hipkins said that's something they will look at closer to election day. "We'll set out closer to the election where we've got common ground with other parties." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Are you enjoying this? Are you not? Tell us what to do more of, and what you'd like to hear less of. The Reykjavík Grapevine's Iceland Roundup brings you the top news with a healthy dash of local views. In this episode, Grapevine publisher Jón Trausti Sigurðarson is joined by Heimildin journalist Aðalsteinn Kjartansson, and Grapevine friend and contributor Sindri Eldon to roundup the stories making headlines in recent weeks. On the docket this week are: Terrible Air Quality in Reykjavík The last few days, with cold and still weather, saw air quality in Reykjavík plummet.ADHD And Driving In IcelandAn Icelandic attorney wanted to bring it to the attention of the public that every so often people in Iceland loose their driver's license because they are taking ADHD medication. The reason, they don't have a prescription.Horse And ToothA person that bought a 13 year old horse wanted to return the horse because it had an extra tooth. The case was taken to consumer court, where the buyer lost. The court pointed out that the horse seems to have lived with the extra tooth for at least a decade without issue, and therefore the extra tooth was not enough ground for returning the horse.Progressive Party Votes New ChairmanOver the weekend the Progressive Party, on of Iceland's oldest political parties, voted for a new chairman. The winner was Lilja Alfreðsdóttir, a former MP and minister.Man. United Owner Says UK “Colonized by Immigrants”Jim Ratcliffe, billionaire owner of Manchester United, said publicly that the UK had been “colonized by immigrants”. The comment received a lot of pushback in the UK, for various reasons. One of which is that Ratcliffe doesn't even live or pay tax in the UK, but in Monaco. The comments were thought to be quite ironic to Icelanders because Ratcliffe is the single biggest landowner in Iceland, after the state, municipalities and the church, having thus, in his own way, been “colonizing” Iceland.The Last Week In HealthcareThe past weeks have been rough for the good name of the Icelandic Health Care system and Icelandic health in general. The emergency room in Reykjavík is so full that it pretty much doesn't function. On top of that it turns out Icelanders are way too fat, and the minister is pondering to propose a tax on sugar. Lastly, a poll revealed that 83% of Icelanders want to put ban energy drinks,Support the show------------------------------------------------------------------------------------------SHOW SUPPORTSupport the Grapevine's reporting by becoming a member of our High Five Club: https://grapevine.is/high-five-club/Or donate to the Grapevine here:https://support.grapevine.isYou can also support the Grapevine by shopping in our online store:https://shop.grapevine.is------------------------------------------------------------------------------------------ This is a Reykjavík Grapevine podcast.The Reykjavík Grapevine is a free alternative magazine in English published 18 times per year, biweekly during the spring and summer, and monthly during the autumn and winter. The magazine covers everything Iceland-related, with a special focus culture, music, food and travel. The Reykjavík Grapevine's goal is to serve as a trustworthy and reliable source of information for those living in Iceland, visiting Iceland or interested in Iceland. Thanks to our dedicated readership and excellent distribution network, the Reykjavík Grapevine is Iceland's most read English-language publication. You may not agree with what we write or publish, but at least it's not sponsored content.www.grapevine.is

Macca and Kenny talk to Dr Monique Ryan, Indi MP for Kooyong, Update from Canberra + Australia’s Addiction Gambling Commercials As of late 2025 and early 2026, Dr. Monique Ryan, independent MP for Kooyong, has continued to heavily advocate for a total ban on gambling advertising in Australia, positioning the issue as a critical public health crisis.  Continued Pressure: Dr. Ryan has been consistent in challenging the Albanese Government over its delay in acting on the “Murphy Report” (June 2023), which recommended a comprehensive ban on online gambling ads. “Hard to Understand” Delay: She has highlighted the irony of the government moving to ban social media for children while failing to implement a similar ban on online gambling advertising that targets young people. Resignation from Parliamentary Sports Club: In October 2025, Dr. Ryan resigned from the Parliamentary Sports Club to protest its association with the gambling industry, stating the industry is “predatory and insidious”. Focus on Public Health: She argues that gambling addiction is a public health issue similar to drug addiction, driving domestic violence, family breakdown, and financial ruin. 2026 Legislative Focus: Her recent activities in 2026 have also centered on criticizing the government’s handling of HECS debt (Job-Ready Graduates scheme) and advocating for safer digital spaces. Australia’s Gambling Commercials Crisis The Problem: Australia is noted to have the highest per-capita gambling losses in the world, with roughly $32 billion lost annually. Targeting Children: Dr. Ryan has stated that children are being targeted by betting ads on social media, creating a “generation primed for addiction”. Call for Total Ban: She supports a total ban on gambling advertising across TV, radio, social media, and on sports uniforms. Government Response: Despite overwhelming public support (reported at 85%) for a ban, the government has been accused of acting too slowly due to pressure from media companies and sporting codes that profit from gambling partnerships.  Dr. Ryan continues to urge the government to adopt all 31 recommendations of the Murphy Report to reduce the impact of gambling on Australian families.    The post Sat, 14th, Feb, 2026: Dr Monique Ryan, Indi MP for Kooyong, Update from Canberra + Australia’s Addiction Gambling Commercials appeared first on Saturday Magazine.

Macca and Kenny are joined live on air by Peter Khalil, – MP for Wills & Asst Min. for Defence; Reaction to Lib spill; news from Coburg and sale of Defence sites across Melbourne The post Sat, 14th, Feb, 2026: Peter Khalil, – MP for Wills & Asst Min. for Defence; Reaction to Lib spill; news from Coburg and sale of Defence sites across Melbourne appeared first on Saturday Magazine.

“The government must provide emergency liquidity support to the Cocoa Board to settle the debts of our cocoa farmers. But first, he should sack Randy Abbey for his poor performance and appoint a competent person with the right expertise to take over,” - Kojo Oppong Nkrumah, MP for Ofoase-Ayirebi.

An MP tells BH there should be a new inquiry over Andrew's time as UK Trade Envoy. Also: reviews of Wuthering Heights and how retraining in middle age can be liberating.

On the Mike Hosking Breakfast Full Show Podcast for Monday the 16th of February, Eden Park boss Nick Sautner got his wish and we can finally use Eden Park as a proper stadium - plus the worst kept secret, State of Origin is indeed coming to NZ. The Prime Minister responds to his coalition partner's ideas of getting rid of the Maori seats and dropping some MP's from Parliament, plus these cultural leave entitlements in the public sector. Jason Pine and Andrew Saville cover off the chaos of the SailGP, the beginning of Super Rugby and F1 testing. Get the Mike Hosking Breakfast Full Show Podcast every weekday morning on iHeartRadio, or wherever you get your podcasts.See omnystudio.com/listener for privacy information.

I det här avsnittet av Politik i Fokus samtalar Mats Lindblom (L) med Marie Åkesdotter (MP), Agneta Hansson (L) och Hanne Sofia Carlsson (C) om de många initiativ som oppositionen har tagit i Tyresö – och de frågor som engagerar lokalt just nu. I Mitt i Tyresö har vi kunnat läsa att inget händer med det planerade ridhuset i Fårdala. Liberalerna vill att ridhuset byggs enligt tidigare planer – men vi vill också att kommunen utreder möjligheterna för ett ridhus i Uddby för att stärka ridverksamheten i hela kommunen. Samtalet berör även Tyresö gymnasiums toppresultat, där fler elever än tidigare tar examen. Liberalerna har lagt förslag för att bygga vidare på framgångarna och fortsätta utveckla gymnasiet. Panelen diskuterar också behovet av fysiska trygghetsskapande åtgärder runt våra skolor, samt hur vi kan få fler unga att engagera sig i samhällsfrågor. Centerpartiet har här föreslagit att inrätta ett ungdomsråd i Tyresö. Avsnittet avslutas med en diskussion om Tyresö Bostäders utmaningar, inte minst när bolaget ska investera i särskilda bostäder för äldre. Där lyfts också Centerpartiets förslag om att se över hyrorna i de särskilda boendena. Producent och ansvarig utgivare: Andreas Froby

Tous les parcours pour intégrer une école d'ingénieurLes intervenants de cette conférenceDarine ABI HAIDAR, Maître de conférences, Responsable du parcours Cycle Universitaire de Préparation aux Grandes Écoles, CUPGE Université Paris CitéDamien BREGIROUX, Responsable du parcours préparatoire de Polytech SorbonneBenjamin DE PROST, Directeur des études du premier cycle à l'ESME, école d'ingénieursMickaël PROST, Professeur de mathématiques au lycée Louis-le-Grand en filière MP et ancien président de l'Union des professeurs de classes préparatoires scientifiques (UPS)Angela VASANELLI, Professeure Université Paris Cité – Directrice de l'EIDDAnimé par Annick Soubaï, Directrice du CIO des Enseignements supérieurs en SorbonneLes Conférences du Salon Post BacDans le cadre du partenariat conclu entre AZIMUT et le Salon PostBac, nous relayons la diffusion de l'ensemble des conférences à l'attention de notre communauté de parents. Ces conférences ont été enregistrées dans les conditions du direct lors du Salon PostBac les 10 et 11 janvier 2025.Animées par les psychologues de l'Éducation nationale, spécialistes du conseil en orientation , les conférences du Salon Postbac 2025 permettent de dresser le tableau de l'offre de formation et des choix qui se posent.Pour en savoir plus sur le Salon Postbac : https://www.reussirpostbac.fr/ℹ️ SUIVEZ L'ACTUALITÉ DE L'ORIENTATIONInscrivez-vous à la newsletter Les Clés de l'orientation : https://azimut-orientation.com/abonnez-vous-a-la-newsletter/ ( vous recevrez en cadeau un guide téléchargeable)

High rents, rising food costs and a perceived lack of opportunities are driving young people out of New Zealand. Last year, more people left than ever before. What can be done to improve living conditions and stop the loss of young talent? The current government has opened the question of Māori land rights in a quest to exploit New Zealand's natural resources. An attempt to overturn a historic treaty failed last year, but as New Zealand faces an election in the autumn, the issue will not go away. There is much to debate for Jonny Dymond and a panel of political leaders as they face questions from across the country.The Panel: Chris Bishop, MP, National Party and Minister for Housing, Transport and Infrastructure and Leader of the House.Ginny Andersen, MP, Labour Party's Spokeswoman on Jobs, Income, Police and Treaty of Waitangi negotiations.Shane Jones, MP, Deputy Leader of New Zealand First and Minister of Oceans and FisheriesMarama Davidson, MP, Co-leader of the Green party and Spokeswoman on Conservation, Child Poverty Reduction and Social investment.Producer: Charlie Taylor Sound engineers: Tim Heffer, Ian Mitchell and Joe Lawrence

Will government get India trade deal in the bag? Trade minister Todd McClay joins Q+A for an in-depth discussion of the free trade agreement with India, as Labour releases a letter outlining their conditions on what might be needed for them to consider voting for it. It comes amid tensions in the government over the deal, with NZ First leader Winston Peters raising concerns about what the deal will mean for migration. LNG or solar? What solves NZ's energy crisis debated Andrew Eagles from the New Zealand Green Building Council joins Q+A with an exclusive new analysis that outlines why his organisation believes the Liquefied Natural Gas import terminal plan is a mistake, and why a different plan for massive uptake of solar and heat pump hot water systems would work better. Insurance retreat: Where's the safest bet for cover? With insurance companies starting to pull out from offering new policies in severely flood or seismic vulnerable areas, which area has the lowest risk? And should the government step in when insurance companies step back? Rent controls, eviction protections: MP wants to change tenant rights Green MP Tamatha Paul explains her Member's Bill, which would impose rent controls, and make it harder to evict tenants. Join Jack Tame and the Q+A team and find the answers to the questions that matter. Made with the support of NZ on Air.

From the son of a bus driver on a South London council estate to the first Muslim mayor of a major Western capital, Sadiq Khan's story is inseparable from the story of modern London. But with that journey has come a decade at the sharpest end of British politics.In this episode of Full Disclosure, James O'Brien sits down with the Mayor of London to trace the path from a crowded flat in Tooting to City Hall. Khan reflects on his parents' migration from Pakistan, the racism he experienced growing up, and the teachers who helped him see that the rooms of power were not off limits. He describes the leap from human rights lawyer to MP, the gamble of running for mayor, and the reality of governing a city through terror attacks, Brexit, a pandemic and deep political division.They discuss the resurgence of overt racism, the personal cost of public life, and why Khan refuses to let abuse dictate his politics. He speaks candidly about the backlash he faced over equal marriage, the solidarity he believes minorities must show one another, and the responsibility he feels to prove that London remains a city where progress is possible.Attention also turns to the future of the Labour Party. As calls emerge for Keir Starmer to stand down, Khan addresses the speculation directly. He reflects on party unity, leadership under pressure and the dangers of allowing internal divisions to overshadow the broader task facing Labour. For Khan, the question is not about personalities but about purpose: what Labour is for, who it represents, and how it responds at moments when confidence wavers.At its heart, this is a conversation about resilience, representation and the fragile idea of social progress. Can a city that once displayed signs reading “No Blacks, No Irish, No Dogs” continue to move forward.EXCLUSIVE NordVPN Deal -> https://nordvpn.com/fulldisclosure Try it risk-free now with a 30-day money-back guarantee

A listener paying 67% in tax asks if Labour are destroying UK productivity. From the new and improved New Statesman podcast studio, Anoosh and Rachel answer listener questions on tax, student loans and Nigel Farage MP's second (and third, and fourth) jobs.In the mailbag this week:A listener earning over £100,000 writes in to ask why the government is failing to address the "tax trap" that means high-earning parents are "penalised".Would the British public back student loan forgiveness?And why can Nigel Farage and other parliamentarians present TV shows, run consultancies, and earn money on the side of their MP job?SAVE £££ THIS CHRISTMAS:⭐️ Gift big ideas, bold politics, and proper journalism from just £2LISTEN AD-FREE:

This podcast features Gabriele Corso and Jeremy Wohlwend, co-founders of Boltz and authors of the Boltz Manifesto, discussing the rapid evolution of structural biology models from AlphaFold to their own open-source suite, Boltz-1 and Boltz-2. The central thesis is that while single-chain protein structure prediction is largely “solved” through evolutionary hints, the next frontier lies in modeling complex interactions (protein-ligand, protein-protein) and generative protein design, which Boltz aims to democratize via open-source foundations and scalable infrastructure.Full Video PodOn YouTube!Timestamps* 00:00 Introduction to Benchmarking and the “Solved” Protein Problem* 06:48 Evolutionary Hints and Co-evolution in Structure Prediction* 10:00 The Importance of Protein Function and Disease States* 15:31 Transitioning from AlphaFold 2 to AlphaFold 3 Capabilities* 19:48 Generative Modeling vs. Regression in Structural Biology* 25:00 The “Bitter Lesson” and Specialized AI Architectures* 29:14 Development Anecdotes: Training Boltz-1 on a Budget* 32:00 Validation Strategies and the Protein Data Bank (PDB)* 37:26 The Mission of Boltz: Democratizing Access and Open Source* 41:43 Building a Self-Sustaining Research Community* 44:40 Boltz-2 Advancements: Affinity Prediction and Design* 51:03 BoltzGen: Merging Structure and Sequence Prediction* 55:18 Large-Scale Wet Lab Validation Results* 01:02:44 Boltz Lab Product Launch: Agents and Infrastructure* 01:13:06 Future Directions: Developpability and the “Virtual Cell”* 01:17:35 Interacting with Skeptical Medicinal ChemistsKey SummaryEvolution of Structure Prediction & Evolutionary Hints* Co-evolutionary Landscapes: The speakers explain that breakthrough progress in single-chain protein prediction relied on decoding evolutionary correlations where mutations in one position necessitate mutations in another to conserve 3D structure.* Structure vs. Folding: They differentiate between structure prediction (getting the final answer) and folding (the kinetic process of reaching that state), noting that the field is still quite poor at modeling the latter.* Physics vs. Statistics: RJ posits that while models use evolutionary statistics to find the right “valley” in the energy landscape, they likely possess a “light understanding” of physics to refine the local minimum.The Shift to Generative Architectures* Generative Modeling: A key leap in AlphaFold 3 and Boltz-1 was moving from regression (predicting one static coordinate) to a generative diffusion approach that samples from a posterior distribution.* Handling Uncertainty: This shift allows models to represent multiple conformational states and avoid the “averaging” effect seen in regression models when the ground truth is ambiguous.* Specialized Architectures: Despite the “bitter lesson” of general-purpose transformers, the speakers argue that equivariant architectures remain vastly superior for biological data due to the inherent 3D geometric constraints of molecules.Boltz-2 and Generative Protein Design* Unified Encoding: Boltz-2 (and BoltzGen) treats structure and sequence prediction as a single task by encoding amino acid identities into the atomic composition of the predicted structure.* Design Specifics: Instead of a sequence, users feed the model blank tokens and a high-level “spec” (e.g., an antibody framework), and the model decodes both the 3D structure and the corresponding amino acids.* Affinity Prediction: While model confidence is a common metric, Boltz-2 focuses on affinity prediction—quantifying exactly how tightly a designed binder will stick to its target.Real-World Validation and Productization* Generalized Validation: To prove the model isn't just “regurgitating” known data, Boltz tested its designs on 9 targets with zero known interactions in the PDB, achieving nanomolar binders for two-thirds of them.* Boltz Lab Infrastructure: The newly launched Boltz Lab platform provides “agents” for protein and small molecule design, optimized to run 10x faster than open-source versions through proprietary GPU kernels.* Human-in-the-Loop: The platform is designed to convert skeptical medicinal chemists by allowing them to run parallel screens and use their intuition to filter model outputs.TranscriptRJ [00:05:35]: But the goal remains to, like, you know, really challenge the models, like, how well do these models generalize? And, you know, we've seen in some of the latest CASP competitions, like, while we've become really, really good at proteins, especially monomeric proteins, you know, other modalities still remain pretty difficult. So it's really essential, you know, in the field that there are, like, these efforts to gather, you know, benchmarks that are challenging. So it keeps us in line, you know, about what the models can do or not.Gabriel [00:06:26]: Yeah, it's interesting you say that, like, in some sense, CASP, you know, at CASP 14, a problem was solved and, like, pretty comprehensively, right? But at the same time, it was really only the beginning. So you can say, like, what was the specific problem you would argue was solved? And then, like, you know, what is remaining, which is probably quite open.RJ [00:06:48]: I think we'll steer away from the term solved, because we have many friends in the community who get pretty upset at that word. And I think, you know, fairly so. But the problem that was, you know, that a lot of progress was made on was the ability to predict the structure of single chain proteins. So proteins can, like, be composed of many chains. And single chain proteins are, you know, just a single sequence of amino acids. And one of the reasons that we've been able to make such progress is also because we take a lot of hints from evolution. So the way the models work is that, you know, they sort of decode a lot of hints. That comes from evolutionary landscapes. So if you have, like, you know, some protein in an animal, and you go find the similar protein across, like, you know, different organisms, you might find different mutations in them. And as it turns out, if you take a lot of the sequences together, and you analyze them, you see that some positions in the sequence tend to evolve at the same time as other positions in the sequence, sort of this, like, correlation between different positions. And it turns out that that is typically a hint that these two positions are close in three dimension. So part of the, you know, part of the breakthrough has been, like, our ability to also decode that very, very effectively. But what it implies also is that in absence of that co-evolutionary landscape, the models don't quite perform as well. And so, you know, I think when that information is available, maybe one could say, you know, the problem is, like, somewhat solved. From the perspective of structure prediction, when it isn't, it's much more challenging. And I think it's also worth also differentiating the, sometimes we confound a little bit, structure prediction and folding. Folding is the more complex process of actually understanding, like, how it goes from, like, this disordered state into, like, a structured, like, state. And that I don't think we've made that much progress on. But the idea of, like, yeah, going straight to the answer, we've become pretty good at.Brandon [00:08:49]: So there's this protein that is, like, just a long chain and it folds up. Yeah. And so we're good at getting from that long chain in whatever form it was originally to the thing. But we don't know how it necessarily gets to that state. And there might be intermediate states that it's in sometimes that we're not aware of.RJ [00:09:10]: That's right. And that relates also to, like, you know, our general ability to model, like, the different, you know, proteins are not static. They move, they take different shapes based on their energy states. And I think we are, also not that good at understanding the different states that the protein can be in and at what frequency, what probability. So I think the two problems are quite related in some ways. Still a lot to solve. But I think it was very surprising at the time, you know, that even with these evolutionary hints that we were able to, you know, to make such dramatic progress.Brandon [00:09:45]: So I want to ask, why does the intermediate states matter? But first, I kind of want to understand, why do we care? What proteins are shaped like?Gabriel [00:09:54]: Yeah, I mean, the proteins are kind of the machines of our body. You know, the way that all the processes that we have in our cells, you know, work is typically through proteins, sometimes other molecules, sort of intermediate interactions. And through that interactions, we have all sorts of cell functions. And so when we try to understand, you know, a lot of biology, how our body works, how disease work. So we often try to boil it down to, okay, what is going right in case of, you know, our normal biological function and what is going wrong in case of the disease state. And we boil it down to kind of, you know, proteins and kind of other molecules and their interaction. And so when we try predicting the structure of proteins, it's critical to, you know, have an understanding of kind of those interactions. It's a bit like seeing the difference between... Having kind of a list of parts that you would put it in a car and seeing kind of the car in its final form, you know, seeing the car really helps you understand what it does. On the other hand, kind of going to your question of, you know, why do we care about, you know, how the protein falls or, you know, how the car is made to some extent is that, you know, sometimes when something goes wrong, you know, there are, you know, cases of, you know, proteins misfolding. In some diseases and so on, if we don't understand this folding process, we don't really know how to intervene.RJ [00:11:30]: There's this nice line in the, I think it's in the Alpha Fold 2 manuscript, where they sort of discuss also like why we even hopeful that we can target the problem in the first place. And then there's this notion that like, well, four proteins that fold. The folding process is almost instantaneous, which is a strong, like, you know, signal that like, yeah, like we should, we might be... able to predict that this very like constrained thing that, that the protein does so quickly. And of course that's not the case for, you know, for, for all proteins. And there's a lot of like really interesting mechanisms in the cells, but yeah, I remember reading that and thought, yeah, that's somewhat of an insightful point.Gabriel [00:12:10]: I think one of the interesting things about the protein folding problem is that it used to be actually studied. And part of the reason why people thought it was impossible, it used to be studied as kind of like a classical example. Of like an MP problem. Uh, like there are so many different, you know, type of, you know, shapes that, you know, this amino acid could take. And so, this grows combinatorially with the size of the sequence. And so there used to be kind of a lot of actually kind of more theoretical computer science thinking about and studying protein folding as an MP problem. And so it was very surprising also from that perspective, kind of seeing. Machine learning so clear, there is some, you know, signal in those sequences, through evolution, but also through kind of other things that, you know, us as humans, we're probably not really able to, uh, to understand, but that is, models I've, I've learned.Brandon [00:13:07]: And so Andrew White, we were talking to him a few weeks ago and he said that he was following the development of this and that there were actually ASICs that were developed just to solve this problem. So, again, that there were. There were many, many, many millions of computational hours spent trying to solve this problem before AlphaFold. And just to be clear, one thing that you mentioned was that there's this kind of co-evolution of mutations and that you see this again and again in different species. So explain why does that give us a good hint that they're close by to each other? Yeah.RJ [00:13:41]: Um, like think of it this way that, you know, if I have, you know, some amino acid that mutates, it's going to impact everything around it. Right. In three dimensions. And so it's almost like the protein through several, probably random mutations and evolution, like, you know, ends up sort of figuring out that this other amino acid needs to change as well for the structure to be conserved. Uh, so this whole principle is that the structure is probably largely conserved, you know, because there's this function associated with it. And so it's really sort of like different positions compensating for, for each other. I see.Brandon [00:14:17]: Those hints in aggregate give us a lot. Yeah. So you can start to look at what kinds of information about what is close to each other, and then you can start to look at what kinds of folds are possible given the structure and then what is the end state.RJ [00:14:30]: And therefore you can make a lot of inferences about what the actual total shape is. Yeah, that's right. It's almost like, you know, you have this big, like three dimensional Valley, you know, where you're sort of trying to find like these like low energy states and there's so much to search through. That's almost overwhelming. But these hints, they sort of maybe put you in. An area of the space that's already like, kind of close to the solution, maybe not quite there yet. And, and there's always this question of like, how much physics are these models learning, you know, versus like, just pure like statistics. And like, I think one of the thing, at least I believe is that once you're in that sort of approximate area of the solution space, then the models have like some understanding, you know, of how to get you to like, you know, the lower energy, uh, low energy state. And so maybe you have some, some light understanding. Of physics, but maybe not quite enough, you know, to know how to like navigate the whole space. Right. Okay.Brandon [00:15:25]: So we need to give it these hints to kind of get into the right Valley and then it finds the, the minimum or something. Yeah.Gabriel [00:15:31]: One interesting explanation about our awful free works that I think it's quite insightful, of course, doesn't cover kind of the entirety of, of what awful does that is, um, they're going to borrow from, uh, Sergio Chinico for MIT. So he sees kind of awful. Then the interesting thing about awful is God. This very peculiar architecture that we have seen, you know, used, and this architecture operates on this, you know, pairwise context between amino acids. And so the idea is that probably the MSA gives you this first hint about what potential amino acids are close to each other. MSA is most multiple sequence alignment. Exactly. Yeah. Exactly. This evolutionary information. Yeah. And, you know, from this evolutionary information about potential contacts, then is almost as if the model is. of running some kind of, you know, diastro algorithm where it's sort of decoding, okay, these have to be closed. Okay. Then if these are closed and this is connected to this, then this has to be somewhat closed. And so you decode this, that becomes basically a pairwise kind of distance matrix. And then from this rough pairwise distance matrix, you decode kind of theBrandon [00:16:42]: actual potential structure. Interesting. So there's kind of two different things going on in the kind of coarse grain and then the fine grain optimizations. Interesting. Yeah. Very cool.Gabriel [00:16:53]: Yeah. You mentioned AlphaFold3. So maybe we have a good time to move on to that. So yeah, AlphaFold2 came out and it was like, I think fairly groundbreaking for this field. Everyone got very excited. A few years later, AlphaFold3 came out and maybe for some more history, like what were the advancements in AlphaFold3? And then I think maybe we'll, after that, we'll talk a bit about the sort of how it connects to Bolt. But anyway. Yeah. So after AlphaFold2 came out, you know, Jeremy and I got into the field and with many others, you know, the clear problem that, you know, was, you know, obvious after that was, okay, now we can do individual chains. Can we do interactions, interaction, different proteins, proteins with small molecules, proteins with other molecules. And so. So why are interactions important? Interactions are important because to some extent that's kind of the way that, you know, these machines, you know, these proteins have a function, you know, the function comes by the way that they interact with other proteins and other molecules. Actually, in the first place, you know, the individual machines are often, as Jeremy was mentioning, not made of a single chain, but they're made of the multiple chains. And then these multiple chains interact with other molecules to give the function to those. And on the other hand, you know, when we try to intervene of these interactions, think about like a disease, think about like a, a biosensor or many other ways we are trying to design the molecules or proteins that interact in a particular way with what we would call a target protein or target. You know, this problem after AlphaVol2, you know, became clear, kind of one of the biggest problems in the field to, to solve many groups, including kind of ours and others, you know, started making some kind of contributions to this problem of trying to model these interactions. And AlphaVol3 was, you know, was a significant advancement on the problem of modeling interactions. And one of the interesting thing that they were able to do while, you know, some of the rest of the field that really tried to try to model different interactions separately, you know, how protein interacts with small molecules, how protein interacts with other proteins, how RNA or DNA have their structure, they put everything together and, you know, train very large models with a lot of advances, including kind of changing kind of systems. Some of the key architectural choices and managed to get a single model that was able to set this new state-of-the-art performance across all of these different kind of modalities, whether that was protein, small molecules is critical to developing kind of new drugs, protein, protein, understanding, you know, interactions of, you know, proteins with RNA and DNAs and so on.Brandon [00:19:39]: Just to satisfy the AI engineers in the audience, what were some of the key architectural and data, data changes that made that possible?Gabriel [00:19:48]: Yeah, so one critical one that was not necessarily just unique to AlphaFold3, but there were actually a few other teams, including ours in the field that proposed this, was moving from, you know, modeling structure prediction as a regression problem. So where there is a single answer and you're trying to shoot for that answer to a generative modeling problem where you have a posterior distribution of possible structures and you're trying to sample this distribution. And this achieves two things. One is it starts to allow us to try to model more dynamic systems. As we said, you know, some of these structures can actually take multiple structures. And so, you know, you can now model that, you know, through kind of modeling the entire distribution. But on the second hand, from more kind of core modeling questions, when you move from a regression problem to a generative modeling problem, you are really tackling the way that you think about uncertainty in the model in a different way. So if you think about, you know, I'm undecided between different answers, what's going to happen in a regression model is that, you know, I'm going to try to make an average of those different kind of answers that I had in mind. When you have a generative model, what you're going to do is, you know, sample all these different answers and then maybe use separate models to analyze those different answers and pick out the best. So that was kind of one of the critical improvement. The other improvement is that they significantly simplified, to some extent, the architecture, especially of the final model that takes kind of those pairwise representations and turns them into an actual structure. And that now looks a lot more like a more traditional transformer than, you know, like a very specialized equivariant architecture that it was in AlphaFold3.Brandon [00:21:41]: So this is a bitter lesson, a little bit.Gabriel [00:21:45]: There is some aspect of a bitter lesson, but the interesting thing is that it's very far from, you know, being like a simple transformer. This field is one of the, I argue, very few fields in applied machine learning where we still have kind of architecture that are very specialized. And, you know, there are many people that have tried to replace these architectures with, you know, simple transformers. And, you know, there is a lot of debate in the field, but I think kind of that most of the consensus is that, you know, the performance... that we get from the specialized architecture is vastly superior than what we get through a single transformer. Another interesting thing that I think on the staying on the modeling machine learning side, which I think it's somewhat counterintuitive seeing some of the other kind of fields and applications is that scaling hasn't really worked kind of the same in this field. Now, you know, models like AlphaFold2 and AlphaFold3 are, you know, still very large models.RJ [00:29:14]: in a place, I think, where we had, you know, some experience working in, you know, with the data and working with this type of models. And I think that put us already in like a good place to, you know, to produce it quickly. And, you know, and I would even say, like, I think we could have done it quicker. The problem was like, for a while, we didn't really have the compute. And so we couldn't really train the model. And actually, we only trained the big model once. That's how much compute we had. We could only train it once. And so like, while the model was training, we were like, finding bugs left and right. A lot of them that I wrote. And like, I remember like, I was like, sort of like, you know, doing like, surgery in the middle, like stopping the run, making the fix, like relaunching. And yeah, we never actually went back to the start. We just like kept training it with like the bug fixes along the way, which was impossible to reproduce now. Yeah, yeah, no, that model is like, has gone through such a curriculum that, you know, learned some weird stuff. But yeah, somehow by miracle, it worked out.Gabriel [00:30:13]: The other funny thing is that the way that we were training, most of that model was through a cluster from the Department of Energy. But that's sort of like a shared cluster that many groups use. And so we were basically training the model for two days, and then it would go back to the queue and stay a week in the queue. Oh, yeah. And so it was pretty painful. And so we actually kind of towards the end with Evan, the CEO of Genesis, and basically, you know, I was telling him a bit about the project and, you know, kind of telling him about this frustration with the compute. And so luckily, you know, he offered to kind of help. And so we, we got the help from Genesis to, you know, finish up the model. Otherwise, it probably would have taken a couple of extra weeks.Brandon [00:30:57]: Yeah, yeah.Brandon [00:31:02]: And then, and then there's some progression from there.Gabriel [00:31:06]: Yeah, so I would say kind of that, both one, but also kind of these other kind of set of models that came around the same time, were kind of approaching were a big leap from, you know, kind of the previous kind of open source models, and, you know, kind of really kind of approaching the level of AlphaVault 3. But I would still say that, you know, even to this day, there are, you know, some... specific instances where AlphaVault 3 works better. I think one common example is antibody antigen prediction, where, you know, AlphaVault 3 still seems to have an edge in many situations. Obviously, these are somewhat different models. They are, you know, you run them, you obtain different results. So it's, it's not always the case that one model is better than the other, but kind of in aggregate, we still, especially at the time.Brandon [00:32:00]: So AlphaVault 3 is, you know, still having a bit of an edge. We should talk about this more when we talk about Boltzgen, but like, how do you know one is, one model is better than the other? Like you, so you, I make a prediction, you make a prediction, like, how do you know?Gabriel [00:32:11]: Yeah, so easily, you know, the, the great thing about kind of structural prediction and, you know, once we're going to go into the design space of designing new small molecule, new proteins, this becomes a lot more complex. But a great thing about structural prediction is that a bit like, you know, CASP was doing, basically the way that you can evaluate them is that, you know, you train... You know, you train a model on a structure that was, you know, released across the field up until a certain time. And, you know, one of the things that we didn't talk about that was really critical in all this development is the PDB, which is the Protein Data Bank. It's this common resources, basically common database where every biologist publishes their structures. And so we can, you know, train on, you know, all the structures that were put in the PDB until a certain date. And then... And then we basically look for recent structures, okay, which structures look pretty different from anything that was published before, because we really want to try to understand generalization.Brandon [00:33:13]: And then on this new structure, we evaluate all these different models. And so you just know when AlphaFold3 was trained, you know, when you're, you intentionally trained to the same date or something like that. Exactly. Right. Yeah.Gabriel [00:33:24]: And so this is kind of the way that you can somewhat easily kind of compare these models, obviously, that assumes that, you know, the training. You've always been very passionate about validation. I remember like DiffDoc, and then there was like DiffDocL and DocGen. You've thought very carefully about this in the past. Like, actually, I think DocGen is like a really funny story that I think, I don't know if you want to talk about that. It's an interesting like... Yeah, I think one of the amazing things about putting things open source is that we get a ton of feedback from the field. And, you know, sometimes we get kind of great feedback of people. Really like... But honestly, most of the times, you know, to be honest, that's also maybe the most useful feedback is, you know, people sharing about where it doesn't work. And so, you know, at the end of the day, it's critical. And this is also something, you know, across other fields of machine learning. It's always critical to set, to do progress in machine learning, set clear benchmarks. And as, you know, you start doing progress of certain benchmarks, then, you know, you need to improve the benchmarks and make them harder and harder. And this is kind of the progression of, you know, how the field operates. And so, you know, the example of DocGen was, you know, we published this initial model called DiffDoc in my first year of PhD, which was sort of like, you know, one of the early models to try to predict kind of interactions between proteins, small molecules, that we bought a year after AlphaFold2 was published. And now, on the one hand, you know, on these benchmarks that we were using at the time, DiffDoc was doing really well, kind of, you know, outperforming kind of some of the traditional physics-based methods. But on the other hand, you know, when we started, you know, kind of giving these tools to kind of many biologists, and one example was that we collaborated with was the group of Nick Polizzi at Harvard. We noticed, started noticing that there was this clear, pattern where four proteins that were very different from the ones that we're trained on, the models was, was struggling. And so, you know, that seemed clear that, you know, this is probably kind of where we should, you know, put our focus on. And so we first developed, you know, with Nick and his group, a new benchmark, and then, you know, went after and said, okay, what can we change? And kind of about the current architecture to improve this pattern and generalization. And this is the same that, you know, we're still doing today, you know, kind of, where does the model not work, you know, and then, you know, once we have that benchmark, you know, let's try to, through everything we, any ideas that we have of the problem.RJ [00:36:15]: And there's a lot of like healthy skepticism in the field, which I think, you know, is, is, is great. And I think, you know, it's very clear that there's a ton of things, the models don't really work well on, but I think one thing that's probably, you know, undeniable is just like the pace of, pace of progress, you know, and how, how much better we're getting, you know, every year. And so I think if you, you know, if you assume, you know, any constant, you know, rate of progress moving forward, I think things are going to look pretty cool at some point in the future.Gabriel [00:36:42]: ChatGPT was only three years ago. Yeah, I mean, it's wild, right?RJ [00:36:45]: Like, yeah, yeah, yeah, it's one of those things. Like, you've been doing this. Being in the field, you don't see it coming, you know? And like, I think, yeah, hopefully we'll, you know, we'll, we'll continue to have as much progress we've had the past few years.Brandon [00:36:55]: So this is maybe an aside, but I'm really curious, you get this great feedback from the, from the community, right? By being open source. My question is partly like, okay, yeah, if you open source and everyone can copy what you did, but it's also maybe balancing priorities, right? Where you, like all my customers are saying. I want this, there's all these problems with the model. Yeah, yeah. But my customers don't care, right? So like, how do you, how do you think about that? Yeah.Gabriel [00:37:26]: So I would say a couple of things. One is, you know, part of our goal with Bolts and, you know, this is also kind of established as kind of the mission of the public benefit company that we started is to democratize the access to these tools. But one of the reasons why we realized that Bolts needed to be a company, it couldn't just be an academic project is that putting a model on GitHub is definitely not enough to get, you know, chemists and biologists, you know, across, you know, both academia, biotech and pharma to use your model to, in their therapeutic programs. And so a lot of what we think about, you know, at Bolts beyond kind of the, just the models is thinking about all the layers. The layers that come on top of the models to get, you know, from, you know, those models to something that can really enable scientists in the industry. And so that goes, you know, into building kind of the right kind of workflows that take in kind of, for example, the data and try to answer kind of directly that those problems that, you know, the chemists and the biologists are asking, and then also kind of building the infrastructure. And so this to say that, you know, even with models fully open. You know, we see a ton of potential for, you know, products in the space and the critical part about a product is that even, you know, for example, with an open source model, you know, running the model is not free, you know, as we were saying, these are pretty expensive model and especially, and maybe we'll get into this, you know, these days we're seeing kind of pretty dramatic inference time scaling of these models where, you know, the more you run them, the better the results are. But there, you know, you see. You start getting into a point that compute and compute costs becomes a critical factor. And so putting a lot of work into building the right kind of infrastructure, building the optimizations and so on really allows us to provide, you know, a much better service potentially to the open source models. That to say, you know, even though, you know, with a product, we can provide a much better service. I do still think, and we will continue to put a lot of our models open source because the critical kind of role. I think of open source. Models is, you know, helping kind of the community progress on the research and, you know, from which we, we all benefit. And so, you know, we'll continue to on the one hand, you know, put some of our kind of base models open source so that the field can, can be on top of it. And, you know, as we discussed earlier, we learn a ton from, you know, the way that the field uses and builds on top of our models, but then, you know, try to build a product that gives the best experience possible to scientists. So that, you know, like a chemist or a biologist doesn't need to, you know, spin off a GPU and, you know, set up, you know, our open source model in a particular way, but can just, you know, a bit like, you know, I, even though I am a computer scientist, machine learning scientist, I don't necessarily, you know, take a open source LLM and try to kind of spin it off. But, you know, I just maybe open a GPT app or a cloud code and just use it as an amazing product. We kind of want to give the same experience. So this front world.Brandon [00:40:40]: I heard a good analogy yesterday that a surgeon doesn't want the hospital to design a scalpel, right?Brandon [00:40:48]: So just buy the scalpel.RJ [00:40:50]: You wouldn't believe like the number of people, even like in my short time, you know, between AlphaFold3 coming out and the end of the PhD, like the number of people that would like reach out just for like us to like run AlphaFold3 for them, you know, or things like that. Just because like, you know, bolts in our case, you know, just because it's like. It's like not that easy, you know, to do that, you know, if you're not a computational person. And I think like part of the goal here is also that, you know, we continue to obviously build the interface with computational folks, but that, you know, the models are also accessible to like a larger, broader audience. And then that comes from like, you know, good interfaces and stuff like that.Gabriel [00:41:27]: I think one like really interesting thing about bolts is that with the release of it, you didn't just release a model, but you created a community. Yeah. Did that community, it grew very quickly. Did that surprise you? And like, what is the evolution of that community and how is that fed into bolts?RJ [00:41:43]: If you look at its growth, it's like very much like when we release a new model, it's like, there's a big, big jump, but yeah, it's, I mean, it's been great. You know, we have a Slack community that has like thousands of people on it. And it's actually like self-sustaining now, which is like the really nice part because, you know, it's, it's almost overwhelming, I think, you know, to be able to like answer everyone's questions and help. It's really difficult, you know. The, the few people that we were, but it ended up that like, you know, people would answer each other's questions and like, sort of like, you know, help one another. And so the Slack, you know, has been like kind of, yeah, self, self-sustaining and that's been, it's been really cool to see.RJ [00:42:21]: And, you know, that's, that's for like the Slack part, but then also obviously on GitHub as well. We've had like a nice, nice community. You know, I think we also aspire to be even more active on it, you know, than we've been in the past six months, which has been like a bit challenging, you know, for us. But. Yeah, the community has been, has been really great and, you know, there's a lot of papers also that have come out with like new evolutions on top of bolts and it's surprised us to some degree because like there's a lot of models out there. And I think like, you know, sort of people converging on that was, was really cool. And, you know, I think it speaks also, I think, to the importance of like, you know, when, when you put code out, like to try to put a lot of emphasis and like making it like as easy to use as possible and something we thought a lot about when we released the code base. You know, it's far from perfect, but, you know.Brandon [00:43:07]: Do you think that that was one of the factors that caused your community to grow is just the focus on easy to use, make it accessible? I think so.RJ [00:43:14]: Yeah. And we've, we've heard it from a few people over the, over the, over the years now. And, you know, and some people still think it should be a lot nicer and they're, and they're right. And they're right. But yeah, I think it was, you know, at the time, maybe a little bit easier than, than other things.Gabriel [00:43:29]: The other thing part, I think led to, to the community and to some extent, I think, you know, like the somewhat the trust in the community. Kind of what we, what we put out is the fact that, you know, it's not really been kind of, you know, one model, but, and maybe we'll talk about it, you know, after Boltz 1, you know, there were maybe another couple of models kind of released, you know, or open source kind of soon after. We kind of continued kind of that open source journey or at least Boltz 2, where we are not only improving kind of structure prediction, but also starting to do affinity predictions, understanding kind of the strength of the interactions between these different models, which is this critical component. critical property that you often want to optimize in discovery programs. And then, you know, more recently also kind of protein design model. And so we've sort of been building this suite of, of models that come together, interact with one another, where, you know, kind of, there is almost an expectation that, you know, we, we take very at heart of, you know, always having kind of, you know, across kind of the entire suite of different tasks, the best or across the best. model out there so that it's sort of like our open source tool can be kind of the go-to model for everybody in the, in the industry. I really want to talk about Boltz 2, but before that, one last question in this direction, was there anything about the community which surprised you? Were there any, like, someone was doing something and you're like, why would you do that? That's crazy. Or that's actually genius. And I never would have thought about that.RJ [00:45:01]: I mean, we've had many contributions. I think like some of the. Interesting ones, like, I mean, we had, you know, this one individual who like wrote like a complex GPU kernel, you know, for part of the architecture on a piece of, the funny thing is like that piece of the architecture had been there since AlphaFold 2, and I don't know why it took Boltz for this, you know, for this person to, you know, to decide to do it, but that was like a really great contribution. We've had a bunch of others, like, you know, people figuring out like ways to, you know, hack the model to do something. They click peptides, like, you know, there's, I don't know if there's any other interesting ones come to mind.Gabriel [00:45:41]: One cool one, and this was, you know, something that initially was proposed as, you know, as a message in the Slack channel by Tim O'Donnell was basically, he was, you know, there are some cases, especially, for example, we discussed, you know, antibody-antigen interactions where the models don't necessarily kind of get the right answer. What he noticed is that, you know, the models were somewhat stuck into predicting kind of the antibodies. And so he basically ran the experiments in this model, you can condition, basically, you can give hints. And so he basically gave, you know, random hints to the model, basically, okay, you should bind to this residue, you should bind to the first residue, or you should bind to the 11th residue, or you should bind to the 21st residue, you know, basically every 10 residues scanning the entire antigen.Brandon [00:46:33]: Residues are the...Gabriel [00:46:34]: The amino acids. The amino acids, yeah. So the first amino acids. The 11 amino acids, and so on. So it's sort of like doing a scan, and then, you know, conditioning the model to predict all of them, and then looking at the confidence of the model in each of those cases and taking the top. And so it's sort of like a very somewhat crude way of doing kind of inference time search. But surprisingly, you know, for antibody-antigen prediction, it actually kind of helped quite a bit. And so there's some, you know, interesting ideas that, you know, obviously, as kind of developing the model, you say kind of, you know, wow. This is why would the model, you know, be so dumb. But, you know, it's very interesting. And that, you know, leads you to also kind of, you know, start thinking about, okay, how do I, can I do this, you know, not with this brute force, but, you know, in a smarter way.RJ [00:47:22]: And so we've also done a lot of work on that direction. And that speaks to, like, the, you know, the power of scoring. We're seeing that a lot. I'm sure we'll talk about it more when we talk about BullsGen. But, you know, our ability to, like, take a structure and determine that that structure is, like... Good. You know, like, somewhat accurate. Whether that's a single chain or, like, an interaction is a really powerful way of improving, you know, the models. Like, sort of like, you know, if you can sample a ton and you assume that, like, you know, if you sample enough, you're likely to have, like, you know, the good structure. Then it really just becomes a ranking problem. And, you know, now we're, you know, part of the inference time scaling that Gabby was talking about is very much that. It's like, you know, the more we sample, the more we, like, you know, the ranking model. The ranking model ends up finding something it really likes. And so I think our ability to get better at ranking, I think, is also what's going to enable sort of the next, you know, next big, big breakthroughs. Interesting.Brandon [00:48:17]: But I guess there's a, my understanding, there's a diffusion model and you generate some stuff and then you, I guess, it's just what you said, right? Then you rank it using a score and then you finally... And so, like, can you talk about those different parts? Yeah.Gabriel [00:48:34]: So, first of all, like, the... One of the critical kind of, you know, beliefs that we had, you know, also when we started working on Boltz 1 was sort of like the structure prediction models are somewhat, you know, our field version of some foundation models, you know, learning about kind of how proteins and other molecules interact. And then we can leverage that learning to do all sorts of other things. And so with Boltz 2, we leverage that learning to do affinity predictions. So understanding kind of, you know, if I give you this protein, this molecule. How tightly is that interaction? For Boltz 1, what we did was taking kind of that kind of foundation models and then fine tune it to predict kind of entire new proteins. And so the way basically that that works is sort of like instead of for the protein that you're designing, instead of fitting in an actual sequence, you fit in a set of blank tokens. And you train the models to, you know, predict both the structure of kind of that protein. The structure also, what the different amino acids of that proteins are. And so basically the way that Boltz 1 operates is that you feed a target protein that you may want to kind of bind to or, you know, another DNA, RNA. And then you feed the high level kind of design specification of, you know, what you want your new protein to be. For example, it could be like an antibody with a particular framework. It could be a peptide. It could be many other things. And that's with natural language or? And that's, you know, basically, you know, prompting. And we have kind of this sort of like spec that you specify. And, you know, you feed kind of this spec to the model. And then the model translates this into, you know, a set of, you know, tokens, a set of conditioning to the model, a set of, you know, blank tokens. And then, you know, basically the codes as part of the diffusion models, the codes. It's a new structure and a new sequence for your protein. And, you know, basically, then we take that. And as Jeremy was saying, we are trying to score it and, you know, how good of a binder it is to that original target.Brandon [00:50:51]: You're using basically Boltz to predict the folding and the affinity to that molecule. So and then that kind of gives you a score? Exactly.Gabriel [00:51:03]: So you use this model to predict the folding. And then you do two things. One is that you predict the structure and with something like Boltz2, and then you basically compare that structure with what the model predicted, what Boltz2 predicted. And this is sort of like in the field called consistency. It's basically you want to make sure that, you know, the structure that you're predicting is actually what you're trying to design. And that gives you a much better confidence that, you know, that's a good design. And so that's the first filtering. And the second filtering that we did as part of kind of the Boltz2 pipeline that was released is that we look at the confidence that the model has in the structure. Now, unfortunately, kind of going to your question of, you know, predicting affinity, unfortunately, confidence is not a very good predictor of affinity. And so one of the things that we've actually done a ton of progress, you know, since we released Boltz2.Brandon [00:52:03]: And kind of we have some new results that we are going to kind of announce soon is kind of, you know, the ability to get much better hit rates when instead of, you know, trying to rely on confidence of the model, we are actually directly trying to predict the affinity of that interaction. Okay. Just backing up a minute. So your diffusion model actually predicts not only the protein sequence, but also the folding of it. Exactly.Gabriel [00:52:32]: And actually, you can... One of the big different things that we did compared to other models in the space, and, you know, there were some papers that had already kind of done this before, but we really scaled it up was, you know, basically somewhat merging kind of the structure prediction and the sequence prediction into almost the same task. And so the way that Boltz2 works is that you are basically the only thing that you're doing is predicting the structure. So the only sort of... Supervision is we give you a supervision on the structure, but because the structure is atomic and, you know, the different amino acids have a different atomic composition, basically from the way that you place the atoms, we also understand not only kind of the structure that you wanted, but also the identity of the amino acid that, you know, the models believed was there. And so we've basically, instead of, you know, having these two supervision signals, you know, one discrete, one continuous. That somewhat, you know, don't interact well together. We sort of like build kind of like an encoding of, you know, sequences in structures that allows us to basically use exactly the same supervision signal that we were using to Boltz2 that, you know, you know, largely similar to what AlphaVol3 proposed, which is very scalable. And we can use that to design new proteins. Oh, interesting.RJ [00:53:58]: Maybe a quick shout out to Hannes Stark on our team who like did all this work. Yeah.Gabriel [00:54:04]: Yeah, that was a really cool idea. I mean, like looking at the paper and there's this is like encoding or you just add a bunch of, I guess, kind of atoms, which can be anything, and then they get sort of rearranged and then basically plopped on top of each other so that and then that encodes what the amino acid is. And there's sort of like a unique way of doing this. It was that was like such a really such a cool, fun idea.RJ [00:54:29]: I think that idea was had existed before. Yeah, there were a couple of papers.Gabriel [00:54:33]: Yeah, I had proposed this and and Hannes really took it to the large scale.Brandon [00:54:39]: In the paper, a lot of the paper for Boltz2Gen is dedicated to actually the validation of the model. In my opinion, all the people we basically talk about feel that this sort of like in the wet lab or whatever the appropriate, you know, sort of like in real world validation is the whole problem or not the whole problem, but a big giant part of the problem. So can you talk a little bit about the highlights? From there, that really because to me, the results are impressive, both from the perspective of the, you know, the model and also just the effort that went into the validation by a large team.Gabriel [00:55:18]: First of all, I think I should start saying is that both when we were at MIT and Thomas Yacolas and Regina Barzillai's lab, as well as at Boltz, you know, we are not a we're not a biolab and, you know, we are not a therapeutic company. And so to some extent, you know, we were first forced to, you know, look outside of, you know, our group, our team to do the experimental validation. One of the things that really, Hannes, in the team pioneer was the idea, OK, can we go not only to, you know, maybe a specific group and, you know, trying to find a specific system and, you know, maybe overfit a bit to that system and trying to validate. But how can we test this model? So. Across a very wide variety of different settings so that, you know, anyone in the field and, you know, printing design is, you know, such a kind of wide task with all sorts of different applications from therapeutic to, you know, biosensors and many others that, you know, so can we get a validation that is kind of goes across many different tasks? And so he basically put together, you know, I think it was something like, you know, 25 different. You know, academic and industry labs that committed to, you know, testing some of the designs from the model and some of this testing is still ongoing and, you know, giving results kind of back to us in exchange for, you know, hopefully getting some, you know, new great sequences for their task. And he was able to, you know, coordinate this, you know, very wide set of, you know, scientists and already in the paper, I think we. Shared results from, I think, eight to 10 different labs kind of showing results from, you know, designing peptides, designing to target, you know, ordered proteins, peptides targeting disordered proteins, which are results, you know, of designing proteins that bind to small molecules, which are results of, you know, designing nanobodies and across a wide variety of different targets. And so that's sort of like. That gave to the paper a lot of, you know, validation to the model, a lot of validation that was kind of wide.Brandon [00:57:39]: And so those would be therapeutics for those animals or are they relevant to humans as well? They're relevant to humans as well.Gabriel [00:57:45]: Obviously, you need to do some work into, quote unquote, humanizing them, making sure that, you know, they have the right characteristics to so they're not toxic to humans and so on.RJ [00:57:57]: There are some approved medicine in the market that are nanobodies. There's a general. General pattern, I think, in like in trying to design things that are smaller, you know, like it's easier to manufacture at the same time, like that comes with like potentially other challenges, like maybe a little bit less selectivity than like if you have something that has like more hands, you know, but the yeah, there's this big desire to, you know, try to design many proteins, nanobodies, small peptides, you know, that just are just great drug modalities.Brandon [00:58:27]: Okay. I think we were left off. We were talking about validation. Validation in the lab. And I was very excited about seeing like all the diverse validations that you've done. Can you go into some more detail about them? Yeah. Specific ones. Yeah.RJ [00:58:43]: The nanobody one. I think we did. What was it? 15 targets. Is that correct? 14. 14 targets. Testing. So we typically the way this works is like we make a lot of designs. All right. On the order of like tens of thousands. And then we like rank them and we pick like the top. And in this case, and was 15 right for each target and then we like measure sort of like the success rates, both like how many targets we were able to get a binder for and then also like more generally, like out of all of the binders that we designed, how many actually proved to be good binders. Some of the other ones I think involved like, yeah, like we had a cool one where there was a small molecule or design a protein that binds to it. That has a lot of like interesting applications, you know, for example. Like Gabri mentioned, like biosensing and things like that, which is pretty cool. We had a disordered protein, I think you mentioned also. And yeah, I think some of those were some of the highlights. Yeah.Gabriel [00:59:44]: So I would say that the way that we structure kind of some of those validations was on the one end, we have validations across a whole set of different problems that, you know, the biologists that we were working with came to us with. So we were trying to. For example, in some of the experiments, design peptides that would target the RACC, which is a target that is involved in metabolism. And we had, you know, a number of other applications where we were trying to design, you know, peptides or other modalities against some other therapeutic relevant targets. We designed some proteins to bind small molecules. And then some of the other testing that we did was really trying to get like a more broader sense. So how does the model work, especially when tested, you know, on somewhat generalization? So one of the things that, you know, we found with the field was that a lot of the validation, especially outside of the validation that was on specific problems, was done on targets that have a lot of, you know, known interactions in the training data. And so it's always a bit hard to understand, you know, how much are these models really just regurgitating kind of what they've seen or trying to imitate. What they've seen in the training data versus, you know, really be able to design new proteins. And so one of the experiments that we did was to take nine targets from the PDB, filtering to things where there is no known interaction in the PDB. So basically the model has never seen kind of this particular protein bound or a similar protein bound to another protein. So there is no way that. The model from its training set can sort of like say, okay, I'm just going to kind of tweak something and just imitate this particular kind of interaction. And so we took those nine proteins. We worked with adaptive CRO and basically tested, you know, 15 mini proteins and 15 nanobodies against each one of them. And the very cool thing that we saw was that on two thirds of those targets, we were able to, from this 15 design, get nanomolar binders, nanomolar, roughly speaking, just a measure of, you know, how strongly kind of the interaction is, roughly speaking, kind of like a nanomolar binder is approximately the kind of binding strength or binding that you need for a therapeutic. Yeah. So maybe switching directions a bit. Bolt's lab was just announced this week or was it last week? Yeah. This is like your. First, I guess, product, if that's if you want to call it that. Can you talk about what Bolt's lab is and yeah, you know, what you hope that people take away from this? Yeah.RJ [01:02:44]: You know, as we mentioned, like I think at the very beginning is the goal with the product has been to, you know, address what the models don't on their own. And there's largely sort of two categories there. I'll split it in three. The first one. It's one thing to predict, you know, a single interaction, for example, like a single structure. It's another to like, you know, very effectively search a space, a design space to produce something of value. What we found, like sort of building on this product is that there's a lot of steps involved, you know, in that there's certainly need to like, you know, accompany the user through, you know, one of those steps, for example, is like, you know, the creation of the target itself. You know, how do we make sure that the model has like a good enough understanding of the target? So we can like design something and there's all sorts of tricks, you know, that you can do to improve like a particular, you know, structure prediction. And so that's sort of like, you know, the first stage. And then there's like this stage of like, you know, designing and searching the space efficiently. You know, for something like BullsGen, for example, like you, you know, you design many things and then you rank them, for example, for small molecule process, a little bit more complicated. We actually need to also make sure that the molecules are synthesizable. And so the way we do that is that, you know, we have a generative model that learns. To use like appropriate building blocks such that, you know, it can design within a space that we know is like synthesizable. And so there's like, you know, this whole pipeline really of different models involved in being able to design a molecule. And so that's been sort of like the first thing we call them agents. We have a protein agent and we have a small molecule design agents. And that's really like at the core of like what powers, you know, the BullsLab platform.Brandon [01:04:22]: So these agents, are they like a language model wrapper or they're just like your models and you're just calling them agents? A lot. Yeah. Because they, they, they sort of perform a function on behalf of.RJ [01:04:33]: They're more of like a, you know, a recipe, if you wish. And I think we use that term sort of because of, you know, sort of the complex pipelining and automation, you know, that goes into like all this plumbing. So that's the first part of the product. The second part is the infrastructure. You know, we need to be able to do this at very large scale for any one, you know, group that's doing a design campaign. Let's say you're designing, you know, I'd say a hundred thousand possible candidates. Right. To find the good one that is, you know, a very large amount of compute, you know, for small molecules, it's on the order of like a few seconds per designs for proteins can be a bit longer. And so, you know, ideally you want to do that in parallel, otherwise it's going to take you weeks. And so, you know, we've put a lot of effort into like, you know, our ability to have a GPU fleet that allows any one user, you know, to be able to do this kind of like large parallel search.Brandon [01:05:23]: So you're amortizing the cost over your users. Exactly. Exactly.RJ [01:05:27]: And, you know, to some degree, like it's whether you. Use 10,000 GPUs for like, you know, a minute is the same cost as using, you know, one GPUs for God knows how long. Right. So you might as well try to parallelize if you can. So, you know, a lot of work has gone, has gone into that, making it very robust, you know, so that we can have like a lot of people on the platform doing that at the same time. And the third one is, is the interface and the interface comes in, in two shapes. One is in form of an API and that's, you know, really suited for companies that want to integrate, you know, these pipelines, these agents.RJ [01:06:01]: So we're already partnering with, you know, a few distributors, you know, that are gonna integrate our API. And then the second part is the user interface. And, you know, we, we've put a lot of thoughts also into that. And this is when I, I mentioned earlier, you know, this idea of like broadening the audience. That's kind of what the, the user interface is about. And we've built a lot of interesting features in it, you know, for example, for collaboration, you know, when you have like potentially multiple medicinal chemists or. We're going through the results and trying to pick out, okay, like what are the molecules that we're going to go and test in the lab? It's powerful for them to be able to, you know, for example, each provide their own ranking and then do consensus building. And so there's a lot of features around launching these large jobs, but also around like collaborating on analyzing the results that we try to solve, you know, with that part of the platform. So Bolt's lab is sort of a combination of these three objectives into like one, you know, sort of cohesive platform. Who is this accessible to? Everyone. You do need to request access today. We're still like, you know, sort of ramping up the usage, but anyone can request access. If you are an academic in particular, we, you know, we provide a fair amount of free credit so you can play with the platform. If you are a startup or biotech, you may also, you know, reach out and we'll typically like actually hop on a call just to like understand what you're trying to do and also provide a lot of free credit to get started. And of course, also with larger companies, we can deploy this platform in a more like secure environment. And so that's like more like customizing. You know, deals that we make, you know, with the partners, you know, and that's sort of the ethos of Bolt. I think this idea of like servicing everyone and not necessarily like going after just, you know, the really large enterprises. And that starts from the open source, but it's also, you know, a key design principle of the product itself.Gabriel [01:07:48]: One thing I was thinking about with regards to infrastructure, like in the LLM space, you know, the cost of a token has gone down by I think a factor of a thousand or so over the last three years, right? Yeah. And is it possible that like essentially you can exploit economies of scale and infrastructure that you can make it cheaper to run these things yourself than for any person to roll their own system? A hundred percent. Yeah.RJ [01:08:08]: I mean, we're already there, you know, like running Bolts on our platform, especially on a large screen is like considerably cheaper than it would probably take anyone to put the open source model out there and run it. And on top of the infrastructure, like one of the things that we've been working on is accelerating the models. So, you know. Our small molecule screening pipeline is 10x faster on Bolts Lab than it is in the open source, you know, and that's also part of like, you know, building a product, you know, of something that scales really well. And we really wanted to get to a point where like, you know, we could keep prices very low in a way that it would be a no-brainer, you know, to use Bolts through our platform.Gabriel [01:08:52]: How do you think about validation of your like agentic systems? Because, you know, as you were saying earlier. Like we're AlphaFold style models are really good at, let's say, monomeric, you know, proteins where you have, you know, co-evolution data. But now suddenly the whole point of this is to design something which doesn't have, you know, co-evolution data, something which is really novel. So now you're basically leaving the domain that you thought was, you know, that you know you are good at. So like, how do you validate that?RJ [01:09:22]: Yeah, I like every complete, but there's obviously, you know, a ton of computational metrics. That we rely on, but those are only take you so far. You really got to go to the lab, you know, and test, you know, okay, with this method A and this method B, how much better are we? You know, how much better is my, my hit rate? How stronger are my binders? Also, it's not just about hit rate. It's also about how good the binders are. And there's really like no way, nowhere around that. I think we're, you know, we've really ramped up the amount of experimental validation that we do so that we like really track progress, you know, as scientifically sound, you know. Yeah. As, as possible out of this, I think.Gabriel [01:10:00]: Yeah, no, I think, you know, one thing that is unique about us and maybe companies like us is that because we're not working on like maybe a couple of therapeutic pipelines where, you know, our validation would be focused on those. We, when we do an experimental validation, we try to test it across tens of targets. And so that on the one end, we can get a much more statistically significant result and, and really allows us to make progress. From the methodological side without being, you know, steered by, you know, overfitting on any one particular system. And of course we choose, you know, w

The prime minister and the leaders of all of Canada's major federal parties are expected to travel to Tumbler Ridge, B.C., to attend a vigil in the community on Friday. As the RCMP identifies all eight of the victims murdered in the shooting, RCMP Deputy Commissioner Dwayne McDonald joins Power & Politics for an update on the ongoing investigation. The MP for Tumbler Ridge, Conservative Bob Zimmer, describes how relatives and community members are coping with the tragedy. Then, Democratic Rep. Gregory Meeks introduced the resolution to stop U.S. President Donald Trump's 35 per cent tariffs on Canadian goods that passed with the support of six Republicans on Wednesday night. Meeks says he believes Trump is 'starting to receive' the message that Americans oppose those tariffs.

Confira no Morning Show desta quinta-feira (12): O gabinete do ministro do STF, Dias Toffoli, divulgou uma nota pública para esclarecer sua participação na empresa Maridt e rebater especulações sobre seu envolvimento com Daniel Vorcaro, dono do Banco Master e alvo de investigações da Polícia Federal. No comunicado, Toffoli nega veementemente qualquer relação pessoal ou financeira com o banqueiro. As mensagens extraídas do celular de Daniel Vorcaro caíram como uma bomba dentro do STF, isso porque pode ser encontrado um possível vínculo entre o ministro Dias Toffoli e o banqueiro. Agora caberá ao presidente da Corte, ministro Edson Fachin, o que fazer daqui para frente para proteger o STF e também para falar a respeito do futuro de Toffoli. Atualmente ele é o relator do caso Banco Master no STF, mas pode haver um possível conflito de interesses e então ele pode ser afastado da relatoria e se isso acontecer, ele não vai poder participar nem do julgamento. Para destrinchar o caso, o Morning Show conversa com o Relator Presidente do Tribunal de Ética da OAB, Mauricio Felberg. Em meio às investigações sobre o Banco Master, o BTG Pactual também nega qualquer irregularidade na distribuição de papéis, os CDBs do Banco de Vorcaro. André Esteves, que é o sócio presidente do conselho de administração do BTG, afirmou que o banco não fez nada de errado e que a atuação seguiu as estritas regras de mercado. Um bastidor trazido pela Jovem Pan revela detalhes de um relatório da Polícia Federal envolvendo o banqueiro Daniel Vorcaro e o ministro do STF, Dias Toffoli. Segundo a apuração, Vorcaro teria discutido com seu cunhado, Fabiano Zettel, sobre pagamentos direcionados a uma empresa ligada ao magistrado. A defesa de Toffoli afirma que os valores se referem à venda legítima de uma participação no resort Tayayá e que o ministro desconhecia quem eram os diretores ou sócios do grupo comprador. A Justiça rejeitou duas ações populares que tentavam impedir o desfile da escola de samba Acadêmicos de Niterói, que homenageia o presidente Lula na abertura do Carnaval do Rio de Janeiro. A oposição chegou a recorrer ao Tribunal Superior Eleitoral (TSE) para barrar a apresentação. Apenas 10 dias após a implementação, o programa de escolas cívico-militares de São Paulo já enfrenta um pedido de suspensão na Justiça. O Ministério Público e a Defensoria Pública alegam inconstitucionalidade e "desvio de função", argumentando que a segurança pública não deve se misturar com a gestão pedagógica. O senador Renan Calheiros fez uma acusação explosiva envolvendo o "Centrão" e a cúpula do Tribunal de Contas da União (TCU). Em entrevista, Calheiros afirmou ter relatado ao ministro Edson Fachin (STF) um "clima de constrangimento" na corte de contas. Segundo o parlamentar, o bloco político teria chantageado o presidente do TCU, Vital do Rêgo, para que ele impedisse a liquidação do Banco Master pelo Banco Central. A Justiça estipulou um prazo de 20 dias para a exumação do corpo do cão "Orelha". O deputado estadual Rafael Saraiva, defensor da causa animal, conversou com o Morning Show sobre as reuniões com o Ministério Público. O parlamentar comenta que a mobilização das autoridades levantou uma questão: embora a exumação tenha sido um pedido inicial da sociedade e do MP, agora surgem dúvidas sobre a validade das provas que poderão ser colhidas tanto tempo depois. Após a pressão para que as redes sociais adotem verificação de idade com selfie, o Morning Show debate se a medida é suficiente. O neurocomunicador William Borghetti analisa a complexidade do tema, questionando se a responsabilidade de proteger os menores é da escola, do governo ou da família. Essas e outras notícias você confere no Morning Show.

"Ofosu Nkansah has finally been granted bail and will no longer face court. His case was clearly politically motivated, because immediately after giving an interview on this show, we were called back and the bail process began," - Nana Nana Agyei Baffour Awuah, MP for Manhyia South and lawyer for Kofi Ofosu Nkansah

"COCOBOD CEO Dr. Randy Abbey and other responsible officers should be sacked. The government must restore the cocoa price to GHC 3,600 and provide support as farmers struggle," - Kojo Oppong Nkrumah, MP for Ofoase Ayirebi, on the revised cocoa price.

A Dover man involved in a hit-and-run while driving without a licence has avoided being sent to prison .24 year-old Tyler Keyes from St Radiguns Road was driving his girlfriend's BMW when he collided with a moped at the Whitfield roundabout last June, leaving the rider unconscious.Also in today's podcast, a meeting is taking place at County Hall to discuss KCC's budget for the next financial year.It's Reform UK's first in charge of the authority and leader Linden Kemkaran has previously said the council is focused on delivering savings for residents. Hear from our local democracy reporter Simon Finlay.There's going to be a public meeting later over the regular closure of a busy road in Medway.The Lower Rainham Road, which runs from Gads Hill to Otterham Quay Lane, was shut for 100 days last year. We've been speaking to Gillingham and Rainham MP Naushabah Khan who has organised the event.Employers across Kent are being encouraged to consider taking on an apprentice.The EKC Group is looking for 100 pledges from businesses to consider it in the next 100 days.And, Leigh-Anne has been on our sister radio station kmfm talking about her debut album.The former Little Mix star caught up with Jack on the Hit List ahead of the release of 'My Ego Told Me To' next week. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dispositivos Cardíacos Eletrônicos Implantáveis (DCEI) fazem parte da rotina de qualquer cardiologista — mas seguem cercados de dúvidas, mitos e decisões tomadas “por insegurança”, especialmente no plantão.Neste episódio do DozeCast, apresentamos um guia prático de DCEI, com foco em marcapasso, CDI e marcapasso provisório, abordando o que realmente muda conduta, evita erro e aumenta segurança no cuidado do paciente.Um episódio pensado para quem está no PS, na enfermaria, no consultório — e não quer errar no básico.Introdução — DCEI no mundo real Por que marcapasso e CDI ainda geram tanta confusão no dia a dia clínico.IMA + dispositivos: onde mora o erro – IMA + marcapasso: quando realmente indicar – IMA + CDI: timing, risco e falsas urgênciasMarcapasso provisório na prática: dicas que salvam – Indicações corretas vs “implante por insegurança” – Programação mínima que todo cardiologista deveria saber – Dicas de implante: acesso, complicações e armadilhas – Quando não insistir no MP provisório – Overdrive pacing na tempestade elétrica: quando faz sentidoComplicações mais comuns de DCEI – Infecção de loja – Perfuração – Trombose – Estímulo frênico: como reconhecer e conduzirECG em pacientes com marcapasso – Como identificar espícula no ECG – Diferença prática entre estimulação unipolar e bipolar – Por que às vezes “não aparece espícula” – Erros clássicos de interpretação no plantão – Taquicardia induzida, mediada e conduzida – PVARP (Período Refratário Atrial Pós-Evento Ventricular) sem mistérioDCEI e atividade física – O que é permitido – O que exige cuidado – Esporte competitivo, musculação e impacto – Como orientar sem proibir tudoMitos e verdades que todo médico ouve – Micro-ondas, porta de banco e aeroporto – Celular, smartwatch e fones magnéticos – Procedimentos cirúrgicos com eletrocautério – Ressonância magnética – Fisioterapia com corrente elétrica – Dentista – PCR e choque externo – RadioterapiaSe você quer ganhar segurança real com marcapasso e CDI, evitar armadilhas comuns e tomar decisões melhores no plantão e no consultório, esse episódio é pra você. ⚡

As we move towards Total Systemic Change, shifting from the death cult of predatory capitalism towards a future we'd actually be proud to leave behind, our absolute baseline non-negotiable foundations must be Clean Air, Clean Water, Clean Soil. We talk a lot about regenerative agriculture on this podcast, and how we can rebuild living soils from the inert growing media we've created in the hellscapes of Industrial Agriculture.  One day, we'll talk about Clean Air.  Today, we're talking about water, that utterly essential part of our biological and spiritual lives.  It should be clean. It should be safe to drink, to swim in, for us and all the species with whom we share our beautiful blue pearl of a watery planet. As we all know… it's not.  It's not because our system values profit over the vibrancy of life. It's not because people in suits have found that if they treat our rivers as open sewers and our oceans as waste dumps they can get away with it.  It's not because for too long, we've believed the stories that say there is no alternative and this is the way the world has to be. But the masks are coming off and activism is increasingly being seen as an act of radical, necessary resistance that can bring people together, bridging across the false, toxic cultural divides that the establishment creates so that we fight ourselves instead of working towards a world founded on different values.  The push for clean water is one of the most unifying drives we have.  It doesn't matter where you are on the political spectrum, you don't vote for sewage to be poured into the rivers, for the dead zones in the oceans to grow and join up, for the rain to be full of forever toxins so that some suit in a company C-suites can buy themselves a new private jet and an invitation to Jeffrey Epstein's private parties. In the UK, we're in an almost unique position because back in the 80s, Margaret Thatcher saw Pinochet privatising the water and sewage companies in Chile and decided this was a fine idea and imported it wholesale to the UK. Our water and sewage companies were privatised at a steal in 1989 and pretty much everyone is agreed this is an incredibly bad idea. Except successive governments.  So people got together and formed their own activist groups based around the rivers near them - there's always at least one - and they are conducting citizen science, holding people's assemblies and generally making enough of a nuisance of themselves that those in power have to take notice.  All this being the case, it's World Water Day on March 22nd every year and this year - we're recording in 2026 for those of you who listen years later - we're talking to Claire Kirby co-founder of Up Sewage Creek and a member of the Sewage Campaign Network.  I first met Claire when my last dog was young - so nearly 20 years ago.  She has a degree in Environmental Science from King's College London and then went on to become a Pet Behaviour Specialist who used to run rather wonderful puppy training classes.  In 2020, following an episode of this podcast, she undertook a training with Trust the People and went on to co-found Up Sewage Creek, an activist group based around the River Severn in Shrewsbury on the borders between England and Wales.  More recently, she has become an active part of the Sewage Campaign Network and is actively campaigning against the latest Government White Paper on the Water Industry which as much of a greenwash/whitewash as you'd expect.  This was a lively conversation, a lot of it focussed on the situation in England, mainly because we live here and it's pretty bad.  But wherever you are in the world, you have water somewhere near you and I guarantee it's not clean - and there will be people around you who care that it become cleaner.  Clearly if you're in a war zone, even if it's an as-yet undeclared civil war, this is not your highest priority and I really do want to honour the people of Minnesota, Maine and Oregon who are taking to the streets in freezing weather to face the Terrorist gangs unleashed by the US government. You have other things to think about than the quality of your water, though not far away in Flint, Michigan, there is one of the most egregious failures of local politics ever to express itself in the quality of the water, so this is clearly a universal problem.   We each do what we can. For those of us not facing pepper spray, uniting our communities so that nobody is ever prepared to join up to the government's shock troops might be the front line.  If testing water is your thing, please do it.  And to find out how and why to connect and converge, let's talk to Claire Kirby of Up Sewage Creek. LinksWorld Water Day https://www.unwater.org/our-work/world-water-dayCastCo https://castco.org/Trust the People https://www.trustthepeople.earth/Top of the Poops (!)  - to help you connect with your MP https://top-of-the-poops.org/constituenciesSewage Campaign Network https://www.sewagecampaignnetwork.org.uk/Up Sewage Creek https://www.upsewagecreek.com/USC on Facebook https://www.facebook.com/groups/upsewagecreekhttps://www.windrushwasp.org/single-post/new-vision-for-water-a-mirage-or-worse?cid=1dfba32d-7702-4cde-974a-08a8580126ffLeft Foot Forward Article https://leftfootforward.org/2026/01/public-ownership-of-water-is-the-only-way-to-deliver-security-efficiency-investment-and-value-for-money/National Security Briefing on BioDiversity Loss in the UK https://www.gov.uk/government/publications/nature-security-assessment-on-global-biodiversity-loss-ecosystem-collapse-and-national-securityOther Accidental Gods water-related podcasts River Dôn Project Tim Smedley 'The Last Drop'BooksDrinkable Rivers - https://drinkablerivers.org/drinkable-rivers-book/About Accidental Gods If you'd like to support us, come along and join the Accidental Gods Membership. Here, you can share in the ideas, the programme that will help you connect to the Web of Life in ways that will last—and you can come to the Gatherings half price. Or if that doesn't appeal, come along to one of the Gatherings. Or buy a subscription/Gathering for a friend... do something that feels like a good exchange of energy and minimises our connection with old economic paradigm. Remember that if any of this is difficult, contact us and we'll find something that works for you. Details below: We offer three strands all rooted in the same soil, drawing from the same river:

Confira no Morning Show desta quarta-feira (11): Aliados do ex-presidente Jair Bolsonaro (PL) afirmam já contar com cinco ministros do Supremo Tribunal Federal (STF) favoráveis à concessão de prisão domiciliar. Entre os nomes citados estão o presidente da Corte, Edson Fachin, além dos ministros Gilmar Mendes, Luiz Fux, André Mendonça e Kassio Nunes Marques. O Supremo opera atualmente com 10 ministros após a aposentadoria de Luís Roberto Barroso. O ranking global de produtividade do trabalho, realizado com dados da Organização Internacional do Trabalho (OIT), apontou que o Brasil está na 94ª posição, de 184 países. O indicador, que mede quanto cada país gera de riqueza por hora trabalhada, coloca o Brasil (US$ 21,2) atrás de vizinhos sul-americanos como Uruguai, Chile, Argentina e até mesmo de Cuba (US$ 22,6). A distância para as potências é ainda maior: a produtividade brasileira é menos da metade da registrada no Japão (o último do G7) e quatro vezes menor que a dos Estados Unidos, líder do grupo. O presidente da Câmara dos Deputados, Hugo Motta (Republicanos), defendeu a discussão. Ele afirmou haver "boa vontade" tanto da base quanto da oposição para debater o tema, citando pesquisas que indicam que quase 80% da população apoia o fim da jornada 6x1. Motta rebateu críticas comparando os "pessimistas" atuais àqueles que, no passado, foram contra o fim da escravidão e a criação da carteira de trabalho, argumentando que o Brasil saiu mais forte e próspero dessas decisões históricas. Levantamento divulgado por Futura/Apex nesta terça-feira (10) apresenta projeções para a eleição presidencial de 2026 e indica que o presidente Luiz Inácio Lula da Silva aparece atrás do senador Flávio Bolsonaro e do governador Tarcísio de Freitas em simulações de 2º turno. O estudo também avaliou cenários de 1º turno, nos quais Lula empata tecnicamente com Flávio Bolsonaro. O governo federal pagou R$ 1,7 bilhão em emendas parlamentares em menos de 60 dias. O valor representa um aumento de 163% em comparação ao mesmo período do ano anterior. Um documento do FBI divulgado em nova leva de arquivos do caso Jeffrey Epstein afirma que Donald Trump teria ligado em 2006 para o então chefe de polícia de Palm Beach, na Flórida, comentando o comportamento do bilionário investigado por crimes sexuais. O registro se baseia em entrevista realizada pelo FBI em 2019 com o ex-chefe policial, que disse ter ouvido de Trump que “todo mundo sabia” das acusações contra Epstein e que ficou aliviado com a investigação. O caso da morte de Juliana Bassetto na academia C4 Gym segue com desdobramentos. O Ministério Público abriu inquérito para investigar toda a rede de academias, suspeitando de falta de Auto de Vistoria do Corpo de Bombeiros e alvarás de funcionamento. O ponto mais chocante da apuração envolve o depoimento do manobrista, que atuava improvisado na manutenção da piscina. Mensagens revelam que, ao comunicar a um dos sócios que uma mulher havia passado mal, a resposta foi "paciência". Após a confirmação da morte, o sócio teria enviado outra mensagem: "Acho bom você sair de casa", sugerindo uma fuga. O Ministério Público (MP) solicitou oficialmente à Justiça a exumação do corpo do Orelha, morto em 4 de janeiro, para confirmar a natureza das lesões na cabeça, que indicam agressão por chutes ou pedaços de pau. Além disso, o MP pediu a abertura de uma investigação contra o Delegado Geral da Polícia Civil, Ulisses Gabriel. A promotoria aponta inconsistências na condução do inquérito e investiga uma possível coação dos adolescentes identificados como autores da agressão. Essas e outras notícias você confere no Morning Show.

AWadd is back in the studio for the first time in almost a month, but the show opens the same as always taking a road trip across the world of sports when we open up the Sports App! Michael Phillips hops on the show as AWadd gets into a spirited debate over who is the best player in college basketball between AJ Dybansta and Darryn Peterson. The debate continues from the last segment as JMoney is on the same side as MP, can he make a dent in AWadd's argument for Dybansta or will he hold firm? The Commanders held the official introductory press conferences for the new hires yesterday. Hear his reactions to the press conference of new OC David Blough. Tune in LIVE every weekday from 12-3 PM everywhere on the Audacy app and locally at 910 the fan and 105.1 FM for more AWadd Radio!!

Stormont should not be treated as a “soft-play area” for politicians, the SDLP leader Claire Hanna has said in an in-depth interview with the BelTel podcast. In it, she gave her views on Irish unity, on Stormont reform and on the SDLP's chances of recovery. Claire Hanna became the leader of the SDLP unopposed in October 2024 having been an MP for south Belfast since 2019. Many commentators say the SDLP has been more stridently pro-unity under Hanna's leadership. Does she agree? Can she square making Northern Ireland work with not wanting it at all? And can she turn around the SDLP's long-term decline. Claire Hanna, joined Ciarán Dunbar on the BelTel. Hosted on Acast. See acast.com/privacy for more information.

When the Conservative Party last entered government, in coalition with the Liberal Democrats, the UK was still finding its feet after the global financial crisis. What followed was a succession of events that quickly came to dominate political life: Brexit, the pandemic, and Russia's invasion of Ukraine.Each of these moments demanded large, costly interventions from the state. But Britain now faces a new set of challenges: an ageing population, a fresh industrial revolution driven by AI, growing global security risks, and the pressures of a changing climate.John Penrose is the founder of the Centre for Small Conservatives. A former Conservative MP, he joins Marc Sidwell to discuss why he's arguing for moving beyond rhetoric and towards serious, practical policy ideas — ones he believes can deliver tangible results in the real world.Guest: John Penrose, former MP and founder of the Centre for Small State ConservativesStay informed with CapX's unmissable daily briefings from the heart of Westminster. Go to capx.co to subscribe. Hosted on Acast. See acast.com/privacy for more information.

The NFL season is officially over as the Seattle Seahawks are the Super Bowl champions. AWadd opens the show as he always does going around the world of sports when we open up the Sports App! MP joins the show on the Hadeed Mercer Rug Cleaning Hotline for some Crosstalk as the two hosts debate what the future should look like for the Commanders ahead of a big day of press conferences with head coach Dan Quinn and the two new coordinators! Host of the 3 bid podcast Tyler Cronin joins the show to talk all about the A-10 and where they stand with just a month to go in the regular season! AWadd gives away some tickets with a secret password, plus he takes you around the commonwealth of Virginia on Chance to dance! Tune in LIVE every weekday from 12-3 PM everywhere on the Audacy app and locally at 910 the fan and 105.1 FM for more AWadd Radio!!

On today's BEST OF AWadd Radio, MP joins the show on the Hadeed Mercer Rug Cleaning Hotline for some Crosstalk as the two hosts debate what the future should look like for the Commanders ahead of a big day of press conferences with head coach Dan Quinn and the two new coordinators! Host of the 3 bid podcast Tyler Cronin joins the show to talk all about the A-10 and where they stand with just a month to go in the regular season! CBS 6's Lane Casadonte joins the show to talk about all things local sports as we go around the 804! AWadd takes us to the corner of college street and University drive as we take a look around the world of college basketball and debate who the best player in the country is. Tune in LIVE every weekday from 12-3 PM everywhere on the Audacy app and locally at 910 the fan and 105.1 FM for more AWadd Radio!!

In this episode, Lisa Witter is joined by Jo Swinson, former UK Member of Parliament and leader of the Liberal Democrats. They explore Jo's journey into politics, beginning with her early interest in activism inspired by the Body Shop's commitment to social issues. Jo reflects on her experiences as the youngest MP and the challenges she faced in a male-dominated environment, particularly during her leadership amidst the Brexit turmoil. The discussion delves into the complexities of power dynamics in politics, the importance of human connections, and the need for long-term thinking in governance. Jo emphasizes the significance of community engagement and the role of individuals in shaping a better political landscape, advocating for a more inclusive and empathetic approach to leadership.External resources: Article: Hard Hope Is a Practice — Start with 1% Book: Equal Power: And How You Can Make It Happen, by Jo SwinsonFollow us on LinkedIn, Instagram, Facebook, and visit our website to stay up to date with our latest news. Subscribe to the Better (Political) Leadership Substack and sign up to our bi-weekly briefing for insights and inspiration on how to build better politics.

“I expected Bryan Acheampong to win the Eastern Region in the presidential primaries and wasn't surprised by the number of votes he garnered”- Sammi Awuku, MP for Akuapem North & Senior Advisor for the Bawumia Campaign.

The NDC's construction of the Suame Interchange will not affect the NPP's electoral fortunes in the Ashanti Region. Governance is a continuous process, and infrastructure development should be guided by economic growth, not partisan politics. - Francis Asenso-Boakye, Former Roads and Highways Minister & MP for Bantama

15 years ago, Victoria Haigh's daughter told her that her father was sexually abusing her. Incredibly, the girl was taken away from mum and her father was handed sole custody of her. Victoria was accused of coaching the child and being an emotionally abusive mother. A couple of years later, she was sent to prison for breaching a no-contact order after accidentally bumping into her daughter at a service station. Victoria was pregnant at the time, with her second daughter Sapphire.She and Sapphire spent six months in a mother-and-baby unit at New Hall prison near Wakefield. After her release they moved to France where Victoria returned to her career as horse-trainer. In 2021 she was handed bombshell information. She learned that UK Athletics had banned her ex-husband for life for grooming a minor! He had remarried in February 2015 but weeks after the wedding he began sending explicit messages on Facebook to a schoolgirl he had met at Doncaster Athletic Club. The girl reported the situation to her PE teacher, who in turn informed the safeguarding teacher at her school.Victoria has launched a YouTube channel It's called Mother's Nature  - How state family court systems remove children and silence mothers. She has also written to MP's - including Rupert Lowe - to offer her advice on grooming gangs and why local authorities are failing children. https://www.youtube.com/@mothersnaturechannelhttps://x.com/HaighVictoria

Dr Sam Rushworth is the UK Labour Party Member of Parliament (MP) for the Bishop Auckland Constituency, he is also a member of The Church of Jesus Christ of Latter-day Saints.I wanted to speak to Sam about his experiences as a British MP and the relationship that his personal faith may or may not have with his politics.Some highlights from this episode include what Sam has found the most challenging in politics, whether he feels he represents Latter-day Saints in Parliament, and how he stays spiritually grounded in an adversarial political system.--Follow For All The Saints on social media for updates and inspiring content:www.instagram.com/forallthesaintspodhttps://www.facebook.com/forallthesaintspod/For All The Saints episodes are released every Monday on YouTube, Spotify, Apple Podcasts and more:https://www.youtube.com/watch?v=TVDUQg_qZIU&list=UULFFf7vzrJ2LNWmp1Kl-c6K9Qhttps://open.spotify.com/show/3j64txm9qbGVVZOM48P4HS?si=bb31d048e05141f2https://podcasts.apple.com/gb/podcast/for-all-the-saints/id1703815271If you have feedback or any suggestions for topics or guests, connect with Ben & Sean via hello@forallthesaints.org or DM on InstagramConversations to Refresh Your Faith.For All The Saints podcast was established in 2023 by Ben Hancock to express his passion and desire for more dialogue around faith, religious belief, and believers' perspectives on the topics of our day. Tune into For All The Saints every Monday on YouTube, Spotify, Apple Podcasts, and more.Follow For All The Saints on social media for daily inspiration.

A Faversham dad is demanding answers after his street was one of the only ones not to be upgraded to full-fibre broadband.Harry Mustoe-Playfair lives on Beech Close and says he's limited to Fibre to the Cabinet, which is an increasingly outdated technology.The fabric printing business owner and his wife both work from home, making fast and reliable internet essential. Harry's been telling the podcast how he feels left in the dark-ages.Also in today's podcast, people living in shared ownership flats in Tunbridge Wells have been told they'll have to pay thousands of pounds for safety work on their balconies.Residents of the Town and Country Housing properties in Greggs Wood Road claim there's been a lack of consultation over contractors, and only one quote.The MP for Tunbridge Wells hopes a new campaign will stop lorries getting stuck in a village high street.Goudhurst has been used as a cut through for HGVs over the past 15 years, but they often get stuck.Mike Martin has successfully petitioned Satnav companies to change their data so trucks won't use the route, but one or two still take the risk. He's been telling the podcast how we can all get involved.Work is due to start this month to replace a bridge on an historic railway line in Kent.The Spa Valley Railway in Tunbridge Wells runs over the Broom Lane Bridge, between High Rocks and Groombridge which has corroded.Volunteers are raising more than £400,000 for the installation of the replacement and are staging a fundraiser next month.In sport, Ronan Hale opened his account at Gillingham as they beat Tranmere Rovers.The January signing scored both goals in the 2-1 victory at Priestfield on Saturday - hear from the striker and manager Gareth Ainsworth. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

News from in and around Westminster with Sean Curran. Sean reports on the latest debate on the assisted dying bill, he's also been hearing from the author of a new book about the campaign for a second Brexit referendum and finding out about the playwright Sheridan's other career, as an MP

This month marks four years since Russia launched its full-scale invasion of Ukraine—a conflict that has reshaped global politics, security, and the international order. To reflect on this grim anniversary, Global in the Granite State welcomes a powerful and deeply personal conversation with Sviatoslav Yuras, Ukraine's youngest member of parliament and a recent participant in the Open World Leadership Program hosted in New Hampshire.Drawing on his experiences as both a lawmaker and a frontline soldier, Yuras offers rare insight into how Ukrainians view the war, the prospects for peace, and the hard lessons learned from broken agreements with Russia. He speaks candidly about why Ukrainians remain deeply skeptical of ceasefires without real security guarantees, how morale endures amid staggering personal sacrifice, and what “Live Free or Die” truly means when national survival is at stake.The conversation also explores the broader global implications of the war—from the authoritarian coalition backing Russia to the role of democratic accountability inside Ukraine itself, including how the country confronts corruption even in wartime. Above all, this episode asks a critical question for Americans and Granite Staters alike: why does Ukraine matter to us—and what role can citizens play in shaping what comes next?This is a sobering, hopeful, and ultimately urgent discussion about sovereignty, democracy, and the cost of indifference in a world where might is once again testing right.Sviatoslav Andriyovych Yurash is the youngest ever Ukrainian MP and a public figure. An active participant in the Revolution of Dignity. MP of Ukraine of the IX convocation from the "Servant of the People" party. Initiator and Chairman of the largest caucus in the history of the Parliament "Values. Dignity. Family", Initiator and Secretary of the second largest Parliamentary Caucus "Intermarium". Member of the Verkhovna Rada Committee on Foreign Policy and Inter-Parliamentary Cooperation, Chairman of the Subcommittee on Relations and Protection of the Rights and Interests of the Ukrainians Abroad.

MP-älsklingen Samir Yosufi har blivit med sportpodd! Tillsammans med Susanna Andrén från Radiosporten snackar de upp veckans viktigaste sporthändelser. Lyssna på Uppsnacket i Sveriges Radios app.

Bill Blair's resignation as MP for Scarborough Southwest has spurred a flurry of political moves in Ontario. Doly Begum, formerly the Ontario New Democratic Party's deputy leader, announced she will run for the federal Liberals in the riding; Liberal MP Nate Erskine Smith announced he'll run in Doly's former provincial riding. John Michael McGrath, Émilie Gougeon-Pelletier, and Sabrina Nanji discuss why this is such a big deal. The Eglinton Crosstown finally has an opening date, but will the opening be full steam ahead or go off the rails? John Michael, Émilie, and Sabrina discuss how the line got here and the precedents that could signal how rocky its start may be. The Darlington Refurbishment Project was delivered early and under budget. This project is part of Ontario's energy strategy and will allow the reactor to continue functioning for years to come. So, why did the province scrap its climate targets when it's on the cusp of a nuclear boom? JMM, Émilie, and Sabrina dig into the larger, legal context. JMM's column: https://www.tvo.org/article/analysis-doug-ford-looks-invincible-will-that-lastSee omnystudio.com/listener for privacy information.

The big game is right around the corner, as we have hit the 4th of our 5 shows of Bud Light Big Game Week! AWadd starts the show as he always does taking you around the world of sports when we open up the Sports App! Today on the Sports App 3 major upsets in college basketball and the NBA trade deadline continues to roll on as the final day to trade is today! MP joins the show from Santa Clara for some crosstalk when Clinton Yates former Washington Post staffer joins the show to talk about the impact of closing the Sports section of the Post and what it means for journalism as a whole. AWadd takes us on the fastbreak as the big story in sports right now is the Wizards making a big move for Anthony Davis, what are AWadd's thoughts on the big move? Is it too soon or are the Wizards ready to compete? Everyday on AWadd Radio we pride ourselves on being the most interactive show in all of Richmond and we have a caller wanting to talk about the NBA and Bnes Hyland, as the former VCU Ram may have finally carved a role out in Minnesota in the NBA! Tune in LIVE every weekday from 12-3 PM everywhere on the Audacy app and locally at 910 the fan and 105.1 FM for more AWadd Radio!!

It's the final day of Bud Light Big Game Week from radio row and we close it out with a banger of a show, but we start as we always do when we open up the Sports App! Today on the Sports App, the NFL Awards show was last night. Did they get the MVP right, the trade deadline has come and gone but Giannis and Ja are still on their teams, plus the Caps and Wizards got big wins last night! MP joins the show for some cross country cross talk as MP has landed back on the east coast ahead of a big game for the Rams v Dayton tonight. AWadd, Intern Macy and MP reflect on their time in San Francisco! AWadd takes us down the lane on the NBA fastbreak as the Wizards were the stars of the show at the NBA trade deadline. They made moves to get Anthony Davis and Trae Young catapulting them to near the top of the eastern conference in the upcoming years! AWadd and the rest of the squad from 910 the fan has taken over San Francisco, but what are the biggest takeaways from silicon valley and what would AWadd recommend anyone who visits the area avoid and make sure they do! Tune in LIVE every weekday from 12-3 PM everywhere on the Audacy app and locally at 910 the fan and 105.1 FM for more AWadd Radio!!

Keir Starmer was not even an MP when Peter Mandelson was part of the New Labour project - a relatively small part. Yet he seems to have had considerable influence over the leadership of Starmer and Morgan McSweeney. Now it is Starmer who is in deep trouble over Mandelson, a figure who was last in government in 2010. How has this happened? Rock & Roll Politics is live at Kings Place next Wednesday. There are a few tickets left, and it will be quite a night in light of fast moving events. Tickets here. Subscribe to Patreon for live events, bonus podcasts and to get the regular podcast a day early and ad free.  Written and presented by Steve Richards. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Keir Starmer's days as prime minister are numbered, Labour MPs have warned, after a week of fury over the appointment of Peter Mandelson as US ambassador despite his friendship with Jeffrey Epstein. While several MPs have said the prime minister's chief of staff, Morgan McSweeney, should take responsibility and resign, the mood surrounding No 10 has seemed ‘terminal', said an MP from the 2024 intake. Lucy Hough talks to political correspondent Alexandra Topping. Help support our independent journalism at theguardian.com/infocus

Who came up with the idea for Let's Play Ten? It was either MP or Ben, but neither of them wants to take the credit. Who would? The boys talk about the world's most performative awards show, some new developments behind the scenes, and MP is surprised to find out that LPT has a public playlist. Speaking of playlists, this episode's batch of brand new indie rock tracks will reverse your prime and delete your tik tok. Don't forget to go and support these artists! Click the links and buy some stuff. EPISODE PLAYLIST:Maia Toakley, “Don't Blame You”Middle Class Fashion, “Criminal Sound”Bleech 9:3, "Cannonball"The Empty Page, "Death On Our Side"Masca, "Diggin'"Martina and the Moons, "Higher Than A Hawk"Always Morning, "This Is It"Modern Woman, "Dashboard Mary"Low Girl, "This House Is On Fire"Sweet Pill, "Slow Burn"Fime, "Soft Science"Cliffords, "Marsh"BONUS TRACK: With thanks to Telemathematics and Joaquin

When the Kyneton Women's football team had had enough of the disrespect they'd been receiving at their old club, the created their own and had secured a spot in a new league too. But it all came undone when their old league appealed the decision to allow the move, leaving them stranded without a home. We speak to the team president and ABC journalist Marnie Vinall about the very big fight these woman have taken on, just to be able to play To sign the petition click here And in headlines today, Alleged WA Invasion Day bomber accessed pro-white male material online; Police investigating the disappearance of South Australian 4yo Gus Worland say inconsistencies with a family member’s story is what led to them declaring them a suspect; The Nationals have reportedly sent opposition leader Sussan Ley a counteroffer for a coalition reunion but one MP says it’s unlikely to be accepted; An alleged ransom note has been received by a local newsroom in Tucson regarding the disappearance of Today Show host Savannah Guthrie’s Mum Nancy; The Commonwealth bank is using AI to help stop domestic violence perpetrators from using the payment description to continue to abuse victim survivors THE END BITS Support independent women's media Check out The Quicky Instagram here GET IN TOUCHShare your story, feedback, or dilemma! Send us a voice note or email us at thequicky@mamamia.com.au CREDITS Hosts: Taylah Strano & Claire Murphy Guest: Natalie Kronfsky - President KWFCMarnie Vinall - ABC sports journalist Audio Producer: Lu Hill Group Executive Producer: Ilaria BrophyBecome a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.

Tom Levitt was exploring a course on 19th century history during the pandemic crisis when he stumbled upon WH Beable's 'Romance of Great Businesses', a 1926 book exploring 32 iconic British companies. He was intrigued by the realisation that many of them still exist today (although mostly as brand names rather than intact corporations). It inspired the former teacher, MP and business advisor to delve into their stories and write his own book – The Business of History: Tales and Lessons from Two Centuries of British Commerce.Listen in to Tom's entertaining discussion with Russell Napier about famous names such as WH Smith, Boots and Cadbury – and, as an interesting aside, the thriving innovation of commercial lending libraries, before the advent of free public reading resources.And if you're interested in Tom's guided history walks around London, find out more by searching for The Business Of History at www.londonwalks.comwww.libraryofmistakes.com

Watch The X22 Report On Video No videos found (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:17532056201798502,size:[0, 0],id:"ld-9437-3289"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="https://cdn2.decide.dev/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs");pt> Click On Picture To See Larger PictureThe green new scam is dead, and in Texas people are now seeing that wind and solar cannot support the electrical load during the cold. China said the quiet part out loud, they were suppose to be the reserve currency. Trump’s new Fed chair help with the transition. Trump is now exposing the criminal underworld the people of this country. The people are seeing all the pieces of the crimes they have committed. When the people see that all the characters are criminals and have done horrible things and that these people are the same ones that have been trying to stop trump, it is game over. Trump is now pushing the Save Act to shutdown the [DS]. Trump is setting the country up for the win.   Economy Report: Texas Wind and Solar Failed During This Week's Winter Storm, Grid Carried by ‘Natural Gas and Coal' The recent snow storm that overtook Texas reportedly crashed the state's wind and solar energy generators, leading to natural gas, coal, and nuclear providing most of the state's electricity. https://twitter.com/RyanMaue/status/2015854614206206101?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E2015854614206206101%7Ctwgr%5Eccb14922c034250da614ea4ff40e89ae08ce9117%7Ctwcon%5Es1_c10&ref_url=https%3A%2F%2Fwww.thegatewaypundit.com%2F2026%2F02%2Freport-texas-wind-solar-failed-weeks-winter-storm%2F According to David Blackmon, an energy-related public policy analyst and consultant, by the early morning hours of Jan. 26, natural gas, goal, and nuclear were providing 89 percent of all the state's power. “Natural gas alone is chugging along at an impressive 68%,” Blackmon reported online on Substack later that same day. Politico similarly reported that the U.S. energy grid “leaned heavily on coal and natural gas generation to satisfy the energy appetite from Winter Storm Fern.” https://twitter.com/mayes_middleton/status/2015822288663228536?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E2015822288663228536%7Ctwgr%5Eccb14922c034250da614ea4ff40e89ae08ce9117%7Ctwcon%5Es1_c10&ref_url=https%3A%2F%2Fwww.thegatewaypundit.com%2F2026%2F02%2Freport-texas-wind-solar-failed-weeks-winter-storm%2F Source: thegatewaypundit.com China is on a ‘strong currency' mission to make the yuan a global reserve: Xi Xi Jinping says the goal of becoming an international powerhouse is a long-term one and will rest on core foundations China needs to build a “strong currency” that can become widely used in international trade, investment and foreign exchange markets, and reach the status of a global reserve. Source:.scmp.com Trump Launches $12 Billion Strategic Mineral Stockpile To Counter China; Rare Earth Stocks Jump The Trump administration is preparing to launch a major initiative aimed at protecting US manufacturers from disruptions in the supply of critical minerals, committing about $12 billion in initial funding to build a strategic stockpile of essential materials, according to Bloomberg. The project, known as Project Vault, is designed to reduce America's dependence on China for rare earths and other strategically important metals. By creating a centralized reserve for civilian industries, officials hope to cushion companies against sudden shortages and sharp price swings that can disrupt production and strain finances. Shares of MP Materials, USA Rare Earth, Critical Metals and other rare earth associated names are higher between 5% and 10% heading into the cash open on Monday on the news. At this point it’s safe to say last week’s Reuters rare earth hit piece (authored most likely at the behest of a disgruntled short), which sent the sector tumbling on disputed claims the Trump administration was seeking to distance itself from the rare earth space by moving away from a price floor on critical metals and suggesting MP’s deal with the government may be in question, has been thoroughly debunked. Even the MP Materials X account was mocking the grotesque misreporting: https://twitter.com/MPMaterials/status/2016734732835573833?ref_src=twsrc%5Etfw Project Vault will be financed through a mix of private and public funding: $1.67 billion is expected to come from private investors, while the US Export-Import Bank is set to provide a $10 billion loan with a 15-year term. The bank's board is scheduled to vote on the deal, which would be the largest in its history. More than a dozen major companies have joined Project Vault, including General Motors, Stellantis, Boeing, Corning, GE Vernova, and Google. Three large trading firms – Hartree Partners, Traxys North America, and Mercuria Energy – will handle sourcing and purchasing materials for the stockpile.    Source: zerohedge.com https://twitter.com/Geiger_Capital/status/2018319873609290010?s=20 https://twitter.com/StephenMoore/status/2017295983940354307?s=20 https://twitter.com/profstonge/status/2018300872447418573?s=20 (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:18510697282300316,size:[0, 0],id:"ld-8599-9832"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="https://cdn2.decide.dev/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs"); Political/Rights https://twitter.com/rickygervais/status/2018249171900227730?s=20 https://twitter.com/NICKIMINAJ/status/2018147684276748388?s=20 https://twitter.com/NICKIMINAJ/status/2018146323581513971?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E2018146323581513971%7Ctwgr%5Ebf8eb4e3fdfcee731660a65a8ed9f8dad15fa004%7Ctwcon%5Es1_c10&ref_url=https%3A%2F%2Fwww.thegatewaypundit.com%2F2026%2F02%2Fnicki-minaj-fires-back-grammys-host-trevor-noah%2F know — yet they continue to attempt bullying. Also, I won't be releasing an album until my contract is renegotiated & until I tell you about all the sabotage this RICO is finding out about Billboard. https://twitter.com/NICKIMINAJ/status/2018156644689920362?s=20   https://twitter.com/TrumpWarRoom/status/2018142074906845333?s=20    accused of being there, not even by the Fake News Media. Noah, a total loser, better get his facts straight, and get them straight fast. It looks like I'll be sending my lawyers to sue this poor, pathetic, talentless, dope of an M.C., and suing him for plenty$. Ask Little George Slopadopolus, and others, how that all worked out. Also ask CBS! Get ready Noah, I'm going to have some fun with you! President DJT https://twitter.com/Patri0tContr0l/status/2018162192676229182?s=20   the TV tells them to. https://twitter.com/DrunkRepub/status/2017198485510963485?s=20   https://twitter.com/MrAndyNgo/status/2018184786209087562?s=20   Lord Mandelson resigns from Labour Party over Epstein links Lord Mandelson says he has resigned his membership of the Labour Party as he does not want to “cause further embarrassment” by his links to the late convicted paedophile Jeffrey Epstein. The former cabinet minister, who was sacked as US ambassador last year because of his past connections to Epstein, appeared in the latest release of files by the US Department of Justice on Friday. Documents suggest Epstein made $75,000 (£55,000) in payments to Lord Mandelson in three separate $25,000 transactions in 2003 and 2004. In his letter to Labour’s general secretary on Sunday, Lord Mandelson said: “I have been further linked this weekend to the understandable furore surrounding Jeffrey Epstein and I feel regretful and sorry about this.” He added: “Allegations which I believe to be false that he made financial payments to me 20 years ago, and of which I have no record or recollection, need investigating by me. Source: bbc.com https://twitter.com/Patri0tContr0l/status/2018011104094380207?s=20  TRUMP'S DOJ that arrested Epstein. Facts are hard for professional liars like Eric Swalwell.   Newly-Released Emails Reveal Jeffrey Epstein May Have a Secret Son  Newly-released emails reveal Jeffrey Epstein may have a secret son. Sarah Ferguson, the former Duchess of York, congratulated Epstein on the birth of his baby boy. Ferguson said she ‘heard from the Duke' that Epstein had a baby boy. The email is date September 21, 2011 so if Epstein has a secret son, he would be 14 years old today. The Daily Mail reported:   Source: thegatewaypundit.com https://twitter.com/JayTC53/status/2018073517368184847?s=20  Jew night” “media elite” and “once the money is paid” https://twitter.com/JayTC53/status/2018128138715443273?s=20 the biggest Trump haters were best friends with Jeffery Epstein https://twitter.com/WarClandestine/status/2018358307052793892?s=20   since been neutralized by King Salman and new crown Prince MBS. This Epstein email reveals (confirms) two sides of the Deep State triangle. House of Saud, and the Rothschilds. https://twitter.com/elonmusk/status/2018185343263019234?s=20  https://twitter.com/elonmusk/status/2017859237502767117?s=20 https://twitter.com/amuse/status/2018351298685419772?s=20   the documents with required redactions. With Trump exonerated & damaging details now pointing toward Democrat power brokers, the pressure has abruptly flipped back to secrecy. https://twitter.com/WarClandestine/status/2018138887655133692?s=20   https://twitter.com/WarClandestine/status/2018017331499213275?s=20      DOGE Geopolitical https://twitter.com/visegrad24/status/2018020919252230227?s=20   since 1996 but was stormed by the police for the eviction 5 weeks ago. Nearly 2000 of the protesters later broke off from the main demonstration and fought the police for hours in the streets. They threw stones, fireworks and homemade bombs while also setting barricades and police vehicles on fire. Many Italians are now calling on Meloni to launch a crackdown against violent far-left extremist. https://twitter.com/EricLDaugh/status/2018311833405293048?s=20    friendship and respect for Prime Minister Modi and, as per his request, effective immediately, we agreed to a Trade Deal between the United States and India, whereby the United States will charge a reduced Reciprocal Tariff, lowering it from 25% to 18%. They will likewise move forward to reduce their Tariffs and Non Tariff Barriers against the United States, to ZERO. The Prime Minister also committed to “BUY AMERICAN,” at a much higher level, in addition to over $500 BILLION DOLLARS of U.S. Energy, Technology, Agricultural, Coal, and many other products. Our amazing relationship with India will be even stronger going forward. Prime Minister Modi and I are two people that GET THINGS DONE, something that cannot be said for most. Thank you for your attention to this matter!   War/Peace  https://twitter.com/AP/status/2017881629440483383?s=20     https://twitter.com/RapidResponse47/status/2018022342731976897?s=20 We have the biggest, most powerful ships in the world over there… hopefully, we’ll make a deal. If we don’t make a deal, then we’ll find out whether or not he was right.” https://twitter.com/WarClandestine/status/2018030967823192563?s=20 Medical/False Flags   [DS] Agenda https://twitter.com/EndWokeness/status/2018176829723398321?s=20  https://twitter.com/Tyler2ONeil/status/2017430244496412840?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E2017430244496412840%7Ctwgr%5E1d06078b39cc73de0216e98cb34ee981fb7d135c%7Ctwcon%5Es1_c10&ref_url=https%3A%2F%2Fwww.dailysignal.com%2F2026%2F02%2F02%2Fbreaking-2-more-arrested-minnesota-church-invasion%2F  Armstrong tells Lemon—who knows the location but is hiding it from his audience—that they’re going to “disrupt business as usual” at what we later learned was Cities Church. Lemon said he would see her there. https://twitter.com/AGPamBondi/status/2018326184468058566?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E2018326184468058566%7Ctwgr%5E1d06078b39cc73de0216e98cb34ee981fb7d135c%7Ctwcon%5Es1_c10&ref_url=https%3A%2F%2Fwww.dailysignal.com%2F2026%2F02%2F02%2Fbreaking-2-more-arrested-minnesota-church-invasion%2F   https://twitter.com/libsoftiktok/status/2018337163188846994?s=20   https://twitter.com/Rightanglenews/status/2018101057902059727?s=20 Anti-ICE Resistance Manuals and Training at Schools Receiving Federal Funding Anti-ICE resistance training manuals, including de-arresting and blocking, are being distributed, and in some cases, the training is being held in schools receiving government funding. Image of de-arresting by Minnesota ICE Watch. Minnesota ICE Watch, the organization that Renee Good and her wife were members of, distributed a document known as the “De-Arrest Primer,” which instructs activists on how to physically interfere with law enforcement officers during arrests. The manual provides detailed guidance on pulling detainees from officers' grips, pushing and pulling officers, breaking holds, and opening law enforcement vehicles to free suspects. The manual also teaches the use of coordinated chanting to create confusion and overwhelm officers during active arrests, as well as surrounding officers until they release detainees. The guide openly acknowledges that these actions may constitute criminal offenses but argues that the risk is justified. Each successful interference is described as a “micro-intifada,” framed as a tactic meant to spread, replicate, and inspire wider disruption. The manual claims these methods originated in pro-Palestinian campus protests and presents them as a model for broader resistance activity. While no single formal publisher is identified, the manual appears to originate from broader activist and radical networks that promote direct physical interference with law enforcement. It has circulated widely through Instagram and other activist communication channels and has been used in training individuals described as “constitutional observers” or “ICE watchers.”   Source: thegatewaypundit.com https://twitter.com/nicksortor/status/2018111147237425556?s=20   https://twitter.com/nicksortor/status/2018114619320017259?s=20   JUST IN: Chicago Mayor Brandon Johnson Signs “ICE On Notice” Executive Order to Prosecute ICE Agents  Chicago Mayor Brandon Johnson at a press conference hosted by Illinois Governor J.B. Pritzker / Screenshot: MSNBC Chicago Mayor Brandon Johnson signed an executive order on Saturday, launching investigations into ICE agents and laying the groundwork for criminal referrals for alleged law violations.  The order “creates a framework for public accountability in the event federal agents violate local or state law while operating in Chicago,” a press release from Johnson's office reads.  “Nobody is above the law. There is no such thing as ‘absolute immunity' in America,” Johnson said in a statement. Source: thegatewaypundit.com https://twitter.com/9mmsmg/status/2017633783638368516?s=20 https://twitter.com/Sec_Noem/status/2018435428932538861?s=20   President Trump's Plan  Federal Appeals Court Tosses Justice Department's Misconduct Complaint Against Judge Boasberg  A federal appeals court tossed out a Justice Department misconduct complaint against Judge James Boasberg. AS previously reported, DC Chief Judge James Boasberg and other DC Judges admitted bias against the Trump Administration during a March 2025 judicial conference with Chief Justice Roberts, according to a memo obtained by The Federalist. For the last year, DC Circuit Court Judges have engaged in a judicial coup against President Trump. Far-left DC judges James Boasberg, Beryl Howell, Chutkan, Berman Jackson and others have ruled against President Trump in every case related to deportations and firings in the Executive Branch. Source: thegatewaypundit.com   https://twitter.com/WallStreetApes/status/2018099758943084657?s=20   agencies, Los Angeles County has more than 36 states combined and 30X MORE than the whole state of Florida and New York “How is that possible? And take a look at this map, a cluster of 287 hospice providers, in a two-mile radius, some in strip malls, unmarked buildings, even a wrecking yard and vacant lot. All of it is just paperwork. I could fill that out in Kazakhstan if I want and get a hospice license waiting for me.” https://twitter.com/elonmusk/status/2018172495535247571?s=20      Rebuilding, can be, without question, the finest Performing Arts Facility of its kind, anywhere in the World. In other words, if we don't close, the quality of Construction will not be nearly as good, and the time to completion, because of interruptions with Audiences from the many Events using the Facility, will be much longer. The temporary closure will produce a much faster and higher quality result!   Based on these findings, and totally subject to Board approval, I have determined that the fastest way to bring The Trump Kennedy Center to the highest level of Success, Beauty, and Grandeur, is to cease Entertainment Operations for an approximately two year period of time, with a scheduled Grand Reopening that will rival and surpass anything that has taken place with respect to such a Facility before.   Therefore, The Trump Kennedy Center will close on July 4th, 2026, in honor of the 250th Anniversary of our Country, whereupon we will simultaneously begin Construction of the new and spectacular Entertainment Complex. Financing is completed, and fully in place! This important decision, based on input from many Highly Respected Experts, will take a tired, broken, and dilapidated Center, one that has been in bad condition, both financially and structurally for many years, and turn it into a World Class Bastion of Arts, Music, and Entertainment, far better than it has ever been before. America will be very proud of its new and beautiful Landmark for many generations to come. Thank you for your attention to this matter!   PRESIDENT DONALD J. TRUMP President Trump to SETTLE $10 BILLION IRS LAWSUIT — Plans to DONATE THE PROCEEDS TO CHARITY President Donald J. Trump is preparing to settle his massive $10 billion lawsuit against the Internal Revenue Service and the U.S. Treasury Department, and he says he will donate the entire payout to reputable charities instead of keeping a penny for himself. President Trump, Eric Trump, Don Jr., and the Trump Org filed a lawsuit against the IRS for leaking their tax returns. They are seeking $10 billion in damages. In September 2023, federal prosecutors charged a former IRS contractor who worked for the agency from 2018 to 2020 with unlawfully obtaining and disseminating the tax details of a high-ranking public official and numerous affluent Americans to media outlets. According to court documents and an official press release from the Department of Justice, Charles Littlejohn, 38, of Washington, D.C., stole tax return information associated with a high-ranking government official, referred to as Public Official A  – now known as Donald Trump. He then disclosed this information to a news organization identified as News Organization 1 – now known as The New York Times. Littlejohn reportedly stole IRS information on thousands of wealthy people. The stolen information was then disseminated to two news outlets (New York Times and ProPublica). “In July and August 2020, Littlejohn separately stole tax return information for thousands of the nation's wealthiest individuals. Littlejohn was again able to evade IRS detection. In November 2020, Littlejohn disclosed this tax return information to News Organization 2, which published over 50 articles using the stolen data. Littlejohn then obstructed the forthcoming investigation into his conduct by deleting and destroying evidence of his disclosures,” the DOJ previously said. L Source: thegatewaypundit.com   https://twitter.com/CynicalPublius/status/2018117811625730171?s=20   some facts: 1. Yesterday’s voter turnout was 94,938. 2. In the same district in 2024, the voter turnout was 400,339. 3. In the same district in 2022, the voter turnout was 277,883. 4. This was a special election to fill a vacant seat resulting from a state senator's promotion into state comptroller. 5. Based on the timing of this election and the next election, and the peculiar nature of Texas state government, it is a 99.99% certainty that this new Democrat will never cast a single vote in the term he is filling. 6. The vote was on a Saturday. I am as passionate a MAGA voter as is alive, but if I lived in TX-SD9, I would have stayed home and enjoyed my Saturday based on fact #5 alone. Is this good for the GOP? No. Is it bad for the GOP? No. Then what is it, CP, you big smartypants? IT'S NOTHING. IT'S MEANINGLESS. So everybody please calm down. For the 2026 midterms, every Trump voter knows that if he does not win, the House will impeach him twice weekly. That fact will be as widely understood as any fact during the 2024 election. There are still many issues Trump needs to work on, and I'm not guaranteeing a 2026 victory. What I AM guaranteeing is that yesterday's TX-SD9 election has as much meaning as peanut butter on a dog's nose. (The dog freaks, everybody laughs, but ultimately the dog gets the peanut butter and we all move on.) https://twitter.com/JohnBasham/status/2018199554764447926?s=20   The Georgia Elections Board. https://twitter.com/WSJ/status/2018277500464275804?s=20 Complaint against Tulsi Gabbard could do ‘grave damage to national security': Report The whistleblower's allegations are so highly classified that documents are being kept locked in a safe and the complaint still hasn't been shared with Congress From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it’s investigating the financials of Elon Musk’s pro-Trump PAC or producing our latest documentary, ‘The A Word’, which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging. At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story. The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford i   Source: the-independent.com There’s an “8 month old complaint” from a “US official” alleging “wrongdoing”   https://twitter.com/awaitekw14/status/2018081688803516456?s=20   ballots from Fulton. Coincidence? No way. COVID wasn’t just a ‘pandemic’—it was the engineered pretext that flipped every state rule on mail-ins, drop boxes, and signature verification. Harvest those ballots, truck them in after 3 a.m. stops, rinse & repeat in swing-state blue zones. Regime change 2.0 after Russiagate flopped.If they can prove those Fulton ballots trace back to illegal harvesting (or even foreign interference via the biolab network), the whole house of cards collapses. Treason on a scale we haven’t seen since the founding. Trump saying ‘interesting things happening’ soon? Understatement of the century. Stay frosty, patriots. The storm is here. https://twitter.com/liz_churchill10/status/2018006616369496424?s=20   https://twitter.com/AndrewDesiderio/status/2018375101847097793?s=20 Andrew Desiderio Schumer issues new statement reiterating that the SAVE Act is “dead on arrival” in the Senate — amid push from GOP Rep. Luna & others “If House Republicans add the SAVE Act to the bipartisan appropriations package it will lead to another prolonged Trump government shutdown” https://twitter.com/EricLDaugh/status/2018378753873969400?s=20 elections from fraud.  REP. AUGUST PFLUGER, Chair of Republican Study Committee nails it: “The House did our job nearly 300 days ago. It's high time that the Senate do theirs!”   President Donald Trump has proposed building a massive triumphal arch in Washington, D.C., often referred to as the “Independence Arch” or “Memorial Circle arch,” to be located on Columbia Island near the Potomac River, close to the Lincoln Memorial and Arlington National Cemetery.  The structure is envisioned as a 250-foot-tall monument, which would make it more than twice the height of the 100-foot Lincoln Memorial, taller than the 70-foot White House, and larger than Paris’s 164-foot Arc de Triomphe—though still shorter than the 630-foot Gateway Arch in St. Louis. Trump’s motivations stem from a desire to create a grand symbol of American pride and exceptionalism, emphasizing that Washington, D.C., is “the only city in the world that’s of great importance that doesn’t have a triumphal arch  The arch signifies Trump’s emphasis on monumental nationalism and grandeur, evoking historical triumphal arches built by emperors and leaders to commemorate triumphs and project power—earning it nicknames like “Arc de Trump.”  (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:13499335648425062,size:[0, 0],id:"ld-7164-1323"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="//cdn2.customads.co/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs");

I can smell the urge to fight in you. With such pungency, you're aiding us in contracting pink eye, wasting MP on a robot, naming a kid "gunner," fearing the mono-eye robot, adapting weird machine parts for androids, refusing to look at naked robot, watching Gryz express facial emotion, worshipping a heroine of yore, aggressively referencing Phantasy Star I, locating the depraved daughter, putting our feelings in metal, rapidly blinking eyes, dying recovered, eliminating another jobber, and fearing her last breath. Put your adversary down by force. 00:00:00 Bubblegum 00:02:23 Intro 00:04:52 World Mappers 00:06:10 Plate System 00:21:00 Termi 00:27:05 Termi Houses 00:31:10 Laeda Tower 00:39:08 GyLaguiah 00:44:59 Real Net 00:49:32 Outro Patreon: patreon.com/retroam Bluesky: @retrogradeamnesia.bsky.social YouTube: www.youtube.com/@RetrogradeAmnesia E-Mail: podcast@retrogradeamnesia.com Website: www.retrogradeamnesia.com  

Keir Starmer jets off to Beijing, leaving Westminster - once again - bubbling with rumours about his future. The King of the North might be off the cards, but Angela Rayner and even Ed Miliband are eyeing up the top spot. Reform thinks GB News Presenter and right-wing activist Matt Goodwin is the right man to be their MP candidate in Gorton and Denton - if only he can shelve his disdain for Manchester… Nish and Coco chew it all over with political journalist Zoë Grünewald.Away from the psychodrama, controversial plans to overhaul special educational needs education in England risk children's legal rights to cut costs. Campaigners Rachel Filmer and Carrie Grant share their concerns with Coco.And surveillance firm Palantir is using medical records to target people for ICE in the US - could the UK be next?This podcast has been edited to remove a story about Matt Goodwin after he clarified the context of his comments about Manchester. We regret the error.CHECK OUT THESE DEALS FROM OUR SPONSORS SHOPIFYhttps://www.shopify.co.uk/podsavetheuk GUESTS Zoë Grünewald, journalist, broadcaster and political commentatorDr Carrie Grant MBE, TV presenter and voice coachRachel Filmer, SEND campaignerUSEFUL LINKSSave Our Children's Rights Campaignhttps://www.saveourchildrensrights.org.uk/Stop Palantir in the NHShttps://goodlawproject.org/campaign/stop-palantir-in-the-nhsCREDITSKeir Starmer / TikTokPod Save America / XGood Law Project / InstagramSky News / YouTubeUKLabour / XPod Save the UK is a Reduced Listening production for Crooked Media.Get in touch - contact us via email: PSUK@reducedlistening.co.ukLike and follow us on Youtube: https://www.youtube.com/@PodSavetheUKInstagram: https://instagram.com/podsavetheukTikTok: https://www.tiktok.com/@podsavetheukBlueSky: https://bsky.app/profile/podsavetheuk.crooked.comFacebook: https://facebook.com/podsavetheukX: https://x.com/podsavetheuk