Podcasts about gsea

Fonctionnaires mobilisés pour les municipales : une demi-journée de congé le lundi 5 mai réclamée par la GSEA by TOPFM MAURITIUS

Une délégation de la Government Services Employees Association (GSEA) s'est récemment rendue à Rodrigues, aux côtés du directeur du Pay Research Bureau (PRB), dans le cadre de la préparation du nouveau rapport attendu cette année. Cette démarche vise à accompagner les quelque 400 membres rodriguais du syndicat dans l'exercice de soumission de propositions et de négociations avec le PRB. Le président de la GSEA, Prakash Baluckram, a souligné que plusieurs recommandations formulées dans les précédents rapports du PRB rencontrent des difficultés d'application sur le terrain rodriguais. Face à ces contraintes, le syndicat a suggéré la création d'un Comité consultatif d'implémentation à Rodrigues. Cette structure aurait pour mission de faciliter la compréhension des mesures et d'en assurer une mise en œuvre plus efficace.

Exercice de fogging contre la dengue : les heures supplémentaires des officiers toujours impayées La Government Services Employees Association (GSEA) prend les rênes de ce combat. Les heures supplémentaires des Public Health And Food Safety Inspectors du ministère de la Santé, des officiers du ministère de l'Agro-industrie, des officiers du ministère de l'Environnement ainsi que des pompiers du Mauritius Fire and Rescue Service (MFRS) restent impayées. Cela concerne les paiements pour une période de 9 mois, entre janvier et septembre 2024, pour des exercices de fogging contre la dengue. Ainsi la GSEA a adressé une lettre au Senior Chief Executive du ministère de la Santé pour demander que ces paiements soient effectués au plus vite. Gheerishsingh Gopaul, secrétaire général de la GSEA, affirme qu'il n'y a pas eu de paiement ou de réaction des autorités malgré les dénonciations de l'association syndicale.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.18.549588v1?rss=1 Authors: Barman, B., Ramirez, M., Liu, Q., Weaver, A. Abstract: Extracellular vesicles (EVs) influence cell phenotypes and functions via protein, nucleic acid and lipid cargoes. EVs are heterogeneous, due to diverse biogenesis mechanisms that remain poorly understood. Our previous study revealed that the endoplasmic reticulum (ER) membrane contact site (MCS) linker protein VAP-A drives biogenesis of a subset of RNA-enriched EVs. Here, we examine the protein content of VAP-A-regulated EVs. Using label-free proteomics, we identified down- and up-regulated proteins in sEVs purified from VAP-A knockdown (KD) colon cancer cells. Gene set enrichment analysis (GSEA) of the data revealed protein classes that are differentially sorted to SEVs dependent on VAP-A. STRING protein-protein interaction network analysis of the RNA-binding protein (RBP) gene set identified several RNA functional machineries that are downregulated in VAP-A KD EVs, including ribosome, spliceosome, mRNA surveillance, and RNA transport proteins. We also observed downregulation of other functionally interacting protein networks, including cadherin-binding, unfolded protein binding, and ATP-dependent proteins. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.27.524249v1?rss=1 Authors: Kelly, K., Lewis, P., Plun-Favreau, H., Manzoni, C. Abstract: Whilst the majority of PD cases are sporadic, much of our understanding of the pathophysiological basis of disease can be traced back to the study of rare, monogenic forms of disease. In the past decade, the availability of Genome-Wide Association Studies (GWAS) has facilitated a shift in focus, toward identifying common risk variants conferring increased risk of developing PD across the population. A recent mitophagy screening assay of GWAS candidates has functionally implicated the non-specific lethal (NSL) complex in the regulation of PINK1-mitophagy. Here, a bioinformatics approach has been taken to investigate the proteome of the NSL complex, to unpick its relevance to PD progression. The mitochondrial NSL interactome has been built, mining 3 separate repositories: PINOT, HIPPIE and MIST, for curated, literature-derived protein-protein interaction (PPI) data. We built; i) the 'mitochondrial interactome', applying gene-set enrichment analysis (GSEA) to explore the relevance of the NSL mitochondrial interactome to PD and, ii) the 'PD-oriented interactome' to uncover biological pathways underpinning the NSL /PD association. In this study, we find the mitochondrial NSL interactome to be significantly enriched for the protein products of PD associated genes, including the Mendelian PD genes LRRK2 and VPS35. Additionally, the PD associated interactome is enriched for mitochondrial processes; "mitochondrial cell death", "mitochondrial protein localisation", "membrane protein localisation" and "mitochondrial transport". Our data points to NSL complex members OGT and WDR5 as key drivers of this increased PD association. These findings strengthen a role for mitochondrial quality control in both familial and sporadic disease. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.23.513322v1?rss=1 Authors: Chen, X., Rong, K., Han, W., Pang, Y., Chai, G. Abstract: In previous research, miR-148a-3p deficiency was observed in bone malformation in hemifacial microsomia. Herein, in this article, we probed into the role of miR-148a-3p in bone physiology by utilizing miR-148a knock-out (KO) mice. Compared with wild-type (WT) or heterozygotic (HE) littermates, miR-148a knock-out mice manifested lower body weight, bone dysplasia with increased bone mass. Through in-vitro experiments, in terms of miR-148a-3p overexpression (miRNA mimic transfection) and knockout (primary cells from WT and KO littermates), we found that miR-148a-3p can suppress osteogenesis, either in the ALP activity or bone nodules formation. Afterward, by means of proteomics, combined with RNA-sequencing and prediction databases of microRNA targets (miRDB and TargetScan), nine candidate genes targeted by miR-148a-3p were identified. Among them, only Itga11 was regulated by mRNA degradation, while the others were modulated via post-transcriptional inhibition. Based on several online databases (GenePaint, BioGPS, STRING), Integrin Subunit Alpha 11 (Itga11) was suggested to play an essential role in osteogenesis and it was confirmed as one direct target of miR-148a-3p by dual-luciferase reporter assay. Meanwhile, gene set enrichment analysis (GSEA) indicated activation of PI3K-Akt signaling pathway and WNT signaling pathway in miR-148a KO mice. The thereafter western blot confirmed that PI3K/Akt/GSK3/{beta}-catenin signaling pathway was involved. Taken together, we demonstrated that miR-148a-3p can inhibit osteogenesis by targeting Itga11 via PI3K/Akt/GSK3/{beta}-catenin pathway. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Peter Thomas has been a serial entrepreneur for more than four decades, specializing in franchising and real estate development. Peter is recognized as one of North America's leading developers and lenders of his time. He has developed billions of dollars in real estate projects, from hotels, multi-unit apartments and condominiums to golf courses. Peter is the past Chairman and Founder of Century 21 Real Estate Canada Ltd., founded Samoth Capital Corporation, a Canadian public real estate company now known as Sterling Centrecorp Inc., and developed the Four Seasons Resort in Scottsdale, Arizona. Thomas also recently stepped down as Chairman of Dogtopia, a dog daycare, boarding and grooming franchise across North America and is currently Chairman Emeritus. He is also an investor in the Canadian, Seattle and Colorado Dogtopia regions. Thomas Pride, his private holding company, is still actively involved in the real estate market. They provide bridge financing for developers to acquire multi-unit apartments and also acquire multi-family apartment projects built in the 70's and 80's that are over 100 units. They renovate the apartments and put them back on the market. Another recent venture is Urban Communities with a mission to improve people's lives through the development and redevelopment of sustainable communities, creating value for residents, stakeholders, and society. They are developers, investors, managers and visionaries and call this “Profit with Purpose”. For his philanthropic contributions, in 2002 Thomas founded LifePilot, a not for profit organization that teaches values based living and leadership workshops to business owners, students, prisoners and individuals. In 2008 the Todd Thomas Institute for Values Based Leadership was established at Royal Road University in Victoria BC. Peter is also the Chairman Emeritus of the Entrepreneur's Organization, Chairman of the Thomas Foundation in Canada and the Todd Thomas Foundation in the US, and recently became Chairman of the GSEA's in Canada. He has also authored many books including two bestsellers: “Never Fight with a Pig” and “Be Great.”   Self Sabotage... we all do it. If you aren't happy with your life, you are self-sabotaging. It's time to get unstuck. Are you making the money you want? Are your relationships what you desire them to be? Is your health where you want it? If not, you are sabotaging yourself. Pat Pearson, M.S.S.W. author, and psychotherapist has found what you create in life is largely determined by what you think you deserve. This podcast focuses on the psychology of stopping self-sabotage and the recovery process of truly creating the life you want and deserve! Do you find yourself procrastinating? You have that report due at noon but you feel compelled to clean your office before sending it. That is a form of procrastination. Procrastination is one of the most common forms of Self-Sabotage. Do you find yourself chronically worried about things that might or might not happen, but eventually never do? What is holding you back from quitting your job, taking a big career leap, or even taking time to rest by traveling and taking vacation time. That can all be attributed to chronic worry. That chronic worry can impact your productivity and overall happiness leading to self-sabotage. Substance abuse, and stress eating can all be considered self-sabotage. It is a journey to recover from these habits but you don't have to spend your life consumed by substance abuse, procrastination, and stress eating. Build your tolerance, with each episode, Author Pat Pearson, MSSW breaks down walls and assists in recovery.    Dive in to her book with five proven strategies for getting "unstuck" at work, in relationships, and in life. Regardless of what your self-sabotage outlet is, procrastination, chronic illness, substance abuse, chronic worry, stress eating, recovery is just around the corner. Pat Pearson can now  not only be invi

Born and raised in a small farm town in Nepal, 2019 GSEA Global Finalist Santosh Pandey was always involved in non-profit organizations to boost his social skills and get more involved. He soon realized he had little creative outlets with these organizations, and he was ready to make real change. When he thought about the one in six Nepalese citizens leaving the country in search of better opportunities, Santosh considered the emotional gap Nepalese families face. In order to bridge this gap sustainably, Santosh started Offering Happiness, a gifting and surprise planning business. Santosh discusses reaching rock bottom with his company, rebuilding and being more open to learning. He speaks about finding resources in GSEA and his unique experience of being one of five GSEA competitors featured on the Disney+ documentary “Own the Room.”

In this episode of the Profit Tool Belt podcast, Dominic Rubino speaks with Stephen Shortt, CEO of multiple companies and president of the Irish chapter of the Entrepreneurs' Organization, about family businesses, successful succession, behavioral assessment, tough conversations, mentorship, the boardroom table versus the dinner table, and more.

Eduardo Baltar, co-presidente do GSEA Brasil - 29/11/2021 by Rádio Gaúcha

Slava Semenchuk is a serial entrepreneur and business surgeon. Specialist in the digital transformation of businesses. He understands best of all in the analysis of business, team, business model, target audience. He is well versed in platforms, uber-mechanics, fintech, blockchain and cryptocurrencies and marketplaces. He understands how to choose the right companies and projects to invest in and how to take assets out of them with profit. Slava is the founder of more than 30 startups. For the last 7 years, he has been engaged in fintech and blockchain projects. Later he founded the service Life-pay.ru - the leader of the Russian mpos market with more than 23,500 client companies for 3 years (2.5 billion turnovers in 2015). In 2016, he was a partner and helped implement the project PAYQR.ru, which attracted more than a 300,000,000 rubles investment. The founder of the BitCoen cryptocurrency, the Block-chain.com project and also the evangelist of the Cryptoindex.io project. Slava secured the title of "Entrepreneur of the Year" in 2014, according to EY and holds two GSEA figurines. The finalist and winner of GSEA 2013, the 2013 Runet Award and Best Telecom MTS Idea (2012) The best business coach of the Skolkovo Business School of Management 2015. Mentor of more than 50 projects. Provides consulting and consulting on the creation, development and improvement of the business. The author of his own methodology "Validation of projects" - helps check your business ideas very quickly. He graduated from MGUPS (Jurisprudence), Moscow Technological Institute (Management), Plekhanov Russian Academy of Economics (Strategic management), MBA of Skolkovo Moscow School of Management. The author of 6 bestselling business books. FIND SLAVA ON SOCIAL MEDIA LinkedIn | Instagram | Facebook | Twitter | Telegram | VKontakte ================================ SUPPORT & CONNECT: Support on Patreon: https://www.patreon.com/denofrich Twitter: https://twitter.com/denofrich Facebook: https://www.facebook.com/denofrich YouTube: https://www.youtube.com/denofrich Instagram: https://www.instagram.com/den_of_rich/ Hashtag: #denofrich © Copyright 2022 Den of Rich. All rights reserved.

Slava Semenchuk is a serial entrepreneur and business surgeon. Specialist in digital transformation of businesses. He understands best of all in the analysis of business, team, business model, target audience. He is well versed in platforms, uber-mechanics, fintech, blockchain and cryptocurrencies and marketplaces. He understands how to choose the right companies and projects to invest in and how to take assets out of them with profit.Slava is the founder of more than 30 startups. For the last 7 years he has been engaged in fintech and blockchain projects. Later he founded the service Life-pay.ru - the leader of the Russian mpos market with more than 23,500 client companies for 3 years (2.5 billion turnover in 2015). In 2016, he was a partner and helped implement the project PAYQR.ru, which attracted more than a 300,000,000 rubles investment. The founder of the BitCoen cryptocurrency, the Block-chain.com project and also the evangelist of the Cryptoindex.io project.Slava secured the title of "Entrepreneur of the Year" in 2014, according to EY and holds two GSEA figurines. The finalist and winner of GSEA 2013, the 2013 Runet Award and Best Telecom MTS Idea (2012)The best business coach of the Skolkovo Business School of Management 2015. Mentor of more than 50 projects. Provides consulting and consulting on the creation, development and improvement of business. The author of his own methodology "Validation of projects" - which helps check your business ideas very quickly.He graduated from MGUPS (Jurisprudence), Moscow Technological Institute (Management), Plekhanov Russian Academy of Economics (Strategic management), MBA of Skolkovo Moscow School of Management. The author of 6 bestselling business books.FIND SLAVA ON SOCIAL MEDIALinkedIn | Instagram | Facebook | Twitter | Telegram | VKontakte================================PODCAST INFO:Podcast website: https://www.uhnwidata.com/podcastApple podcast: https://apple.co/3kqOA7QSpotify: https://spoti.fi/2UOtE1AGoogle podcast: https://bit.ly/3jmA7ulSUPPORT & CONNECT:Support on Patreon: https://www.patreon.com/denofrichTwitter: https://www.instagram.com/denofrich/Instagram: https://www.instagram.com/denofrich/Facebook: https://www.facebook.com/denofrich

Starting out by selling moss door-to-door at five years old, serial entrepreneur Daniel Dubois, a former GSEA and Accelerator-participant-turned-EO member, shares his story of raising US$1 million at the age of 21 and his experience working for Airbnb. He is currently striving to make homeownership accessible to everyone through his newest venture, Key Living. https://www.linkedin.com/in/danielmdubois/ https://keyliving.com/daniel/ https://www.facebook.com/LifeatKey/ https://twitter.com/LIfeAtKey https://www.instagram.com/keylivingcanada/

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.24.058958v1?rss=1 Authors: Fulcher, B. D., Arnatkeviciute, A., Fornito, A. Abstract: The recent availability of whole-brain atlases of gene expression, which quantify the transcriptional activity of thousands of genes across many different brain regions, has opened new opportunities to understand how gene-expression patterns relate to spatially varying properties of brain structure and function. To aid interpretation of a given neural phenotype, gene-set enrichment analysis (GSEA) has become a standard statistical methodology to identify functionally related groups of genes, annotated using systems such as the Gene Ontology (GO), that are associated with a given phenotype. While GSEA has identified functional groups of genes related to diverse aspects of brain structure and function in mouse and human, here we show that these results are affected by substantial statistical biases. Quantifying the false-positive rates of individual GO categories across an ensemble of completely random phenotypic spatial maps, we found an average 875-fold inflation of significant findings relative to expectation in mouse, and a 582-fold inflation in human, with some categories being judged as significant for over 20% of random phenotypes. Concerningly, the probability of a GO category being reported as significant in the extant literature increases with its estimated false-positive rate, suggesting that published reports are strongly affected by the reporting of false-positive bias. We show that the bias is primarily driven by gene--gene coexpression and spatial autocorrelation in transcriptional data, which are not accounted for in conventional GSEA nulls, and we introduce flexible ensemble-based null models that properly account for these effects. Using case studies of structural connectivity degree in mouse and human, we demonstrate that many GO categories that would conventionally be judged as highly significant are in fact consistent with ensembles of random phenotypes. Our results highlight major pitfalls with applying standard GSEA to brain-wide transcriptomic data and outline a solution to this pervasive problem, which is made available as a toolbox. Copy rights belong to original authors. Visit the link for more info

Last week School District 65, which serves the racially, ethnically, and religiously diverse Evanston and Skokie, Illinois communities, went whole hog on disseminating a controversial ideology to captive audiences of other people's children who came to school with open minds and hearts into which “progressives” poured  poison masquerading as inarguable truth. District 65's celebration of what they called “LGBTQ+ Equity Week,” offers a glimpse into the kind of pernicious indoctrination that the cunningly named “Inclusive Curriculum” bill signed into law by Governor J. B. Pritzker will bring to Illinois school children. The mess of poisonous pottage was a project of the Gender and Sexuality Educator Alliance (GSEA), “a group of educators in Evanston/Skokie School District 65 who seek to advocate for inclusive schools for parents, students, and staff.” The GSEA has some eye-popping goals that include... Read more...

This week on NLP for Entrepreneurs When it comes to happiness- we tend to think that happiness is what happens to us when we have everything going our way. And it just isn't the case. This is a throwback to a keynote I did for GSEA, Global Student Entrepreneur Awards, hosted by Entrepreneurs Organization where I share viewpoints with the student competitors on how to be happy and find happiness even if they do not win the competition. On today's show, I break down the 3 ways you can respond to a setback and how to cultivate happiness from that. Klyn shares the 4 drivers to happiness: Perceived progress Perceived control Connection Vision What will you learn? How to navigate changes in a positive way Increase productivity Prevent burnout How to maximize internal joy regardless of external circumstances Tactical strategies for lasting motivation Get ready to learn the most effective, proven practices that alter our mental circuitry to create a heightened sense of fulfillment. From that state, you can close more deals, build a higher performing team, and tap into an endless stream of energy Special mentions: Entrepreneurs Organization GSEA Abundance by Peter Diamandis

Darcy was the national winner of the Global Student Entrepreneurs Award (GSEA). At 23, he's just finished an engineering degree at UNSW and has headed straight into business. In this candid interview we talk about how he is changing the way Australian businesses think about having coffee in the workplace for the better. More info: http://withkua.coand http://gsea.org/

Jesús Arredondo, encargado a nivel global de EO Global Student Entrepeneur Awars en República Dominicana nos cuenta en qué consiste la 5ta competencia para estudiantes universitarios emprendedores de grado y postgrado. ¿Quieres saber de qué trata? ¡Escucha la entrevista!

Jesús Arredondo, encargado a nivel global de EO Global Student Entrepeneur Awars en República Dominicana nos cuenta en qué consiste la 5ta competencia para estudiantes universitarios emprendedores de grado y postgrado. ¿Quieres saber de qué trata? ¡Escucha la entrevista!

Jesús Arredondo, encargado a nivel global de EO Global Student Entrepeneur Awars en República Dominicana nos cuenta en qué consiste la 5ta competencia para estudiantes universitarios emprendedores de grado y postgrado. ¿Quieres saber de qué trata? ¡Escucha la entrevista!

Jesús Arredondo, encargado a nivel global de EO Global Student Entrepeneur Awars en República Dominicana nos cuenta en qué consiste la 5ta competencia para estudiantes universitarios emprendedores de grado y postgrado. ¿Quieres saber de qué trata? ¡Escucha la entrevista!

Kevin has two guests join the show today. Jeff and Mark are in the same forum group at EO, and they come on the show to talk about their different entrepreneurial ventures. Both Mark and Jeff have their own companies, and they share the twists and turns of how they got started, what their goals moving forward are, as well the ways in which EO has influenced and inspired them. Tune in for a fun show!   Key Takeaways: [:52] Jeff shares his lifeline — after going to school and studying photography, he moved to California to either be an actor or figure something else out. From ending up at the wrong place for an interview, to landing a job with that company, and eventually deciding to pursue photography, Jeff now owns his own company (built from the ground up), EclipseCorp. [6:39] Although Jeff and his wife met in California, they moved back to Columbus to buy a house and start a family. Turned about to be a good decision, as the market in Columbus had a lot of potential. Look where they are now! [8:25] Mark shares his lifeline — he also grew up in Cincinnati and received his degree in Landscape Architecture from Ohio State University. After deciding he wanted to be a developer who hired landscape architects, he got a Master’s degree from Florida, and gained professional experience working for several different firms. From a huge opportunity in Pittsburgh, he and his business partners started their own company called Stanbery Development. [14:00] The progress and growth of Stanbery was quite successful in the years leading up to the crash. The crash was a really tough time for the company, but they were able to work with the banks to stabilize their properties, and were able to keep four of their original properties. [15:16] After the crash, members of the company took a break from real estate for a few years. Mark got into World of Beer — this venture taught him a lot about operating businesses, and now they are working to reposition their Stanbery business into the mixed-use arena. [19:46] How did Jeff and Mark become involved with EO? Mark’s business partner “forced him into it kicking and screaming,” but since joining, he has gotten involved with forum, the board, and is currently involved with a GSEA regional position. Jeff was inspired during a lunch to see if he wanted to be part of a forum, and has enjoyed peer-to-peer learning, and has also been involved with the board on a regional level. [25:17] Jeff is now a strategic coach, which encourages stepping away and letting other people run your business, while you work on your business. The tools and tips have been a tremendous help in growing not only his business, but himself as well. [27:35] Mark’s company has spent several sessions with Scott Fritz, and now they are working to get everyone on the same page, so they can decide on a laser focus for moving forward. [29:50] Top 5/Bottom 5 — both Mark and Jeff share some of their bottom five moments. Not all are specifically business related, but this shows how personal struggles can affect business struggles. They talk about the strength of forum as a place to share some of these struggles (and joys) and find support. [36:12] What are the next steps for these guys? Jeff is looking to expand their physical location as well as expand their market. Mark is really hoping to get their big mixed-use project off the ground within the next 12 months. [39:27] Mark and Jeff share how people can help them in their business, as well as other ways to get involved in EO. Mark talks about GSEA, which really helps students entrepreneurs.   Mentioned in This Episode: Columbus Chapter of Entrepreneurs’ Organization EclipseCorp Stanbery Development World of Beer The 40 Hour Work Year

Carlos Villa, CEO de OE, habló en En BLU Jeans sobre la convocatoria para el premio al estudiante emprendedor 2015 GSEA. See omnystudio.com/listener for privacy information.

Meet this week awesome studentpreneur: Leo Lope Lofranco, 22 years old,  student in Biology at Ateneo de Manila and entrepreneur at Project Mercury, Philipines.   Wrap up:  Each studentpreneur's story is different and what works for some people doesn't for others, however I'd like to point out of few things in Leo Lope Franco's journey that are similar to the studentpreneurs I have talked to: Leo wasn't destined to be an entrepreneur, after all that's not what one does in the Philippines. Also, biology students are expected to go to Med school. Well, as you have realised, the supporting environment is essential: in Boston he tried a Startup Weekend which changed his mindset and perspective on the world. He learned that startups are multi disciplinary projects and that he had to learn new skills, such as coding. He benefitted a lot from events and from the GSEA competition. So get involved in such competition whatever field you are in and you might end up as a business owner down the track.   Tips: - Share with everyone, especially your professors, your idea in the infant stage for validation purposes. - Take advantage of free online courses (MOOCS) - Attend Startup Weekend and the Global Student Entrepreneur Award Learn more about Leo Lope Franco on www.studentpreneur.com.au  If you have what it takes you can apply to share your story on air: http://studentpreneur.com.au/pages/contact-form-guest/

Meet this week awesome studentpreneur: Samuelle Dimairho student in Accounting at the Online University of Oxford Brook, UK,  and entrepreneur at Aura Group in Zimbabwe. Each studentpreneur's story is different and what works for some people doesn't for others, however I'd like to point out of few things in Samuelle Dimairho's journey that are similar to the studentpreneurs I have talked to: He started 20 different ideas to to succeed a couple of times, he is another example of starting fast and failing fast. Also he has been a big reader from very early on, which is how he changed his mindset to become an entrepreneur. He listens to a lot of audiobook while commuting so no excuse if you don't have time to read books, you can listen to them. He started very early, at 14, doing internship from which he gained professional experience but also made a lot of connections, that's how he started his network. As always mentors play a great role in his entrepreneurship journey, he has several who have different areas of expertise. He met his first one at church, you never know where your first mentor will come from. Finally he really enjoyed the Global Student Entrepreneurship Award competition where he met likeminded studentpreneurs and mature entrepreneurs. So apply now at GSEA.org.    Book:  - Rich dad, poor dad (Robert Kiyosaki) - The 7 Habits of Highly Effective People (Stephen Covey)   Tips: - Share with everyone, especially your professors, your idea in the infant stage for validation purposes. - Take advantage of free online courses (MOOCS) - Attend Startup Weekend the Global Student Entrepreneur Award

Meet this week awesome studentpreneurs: Mohammed Fawaz, 22  years old, student in Business Information Management system at Middlesex University, London and founder of Global Tutors in Sri Lanka. Wrap up: Each studentpreneurs' story is different and what works for some people doesn't for others, however I'd like to point out of few things in Mohammed Fawase's journey that are similar to the studentpreneurs I studied in my research: He embraced networking from very early on and subsequently met several influential people, including two mentors who even ended up investing in his business. There is no particular skills for networking, everyone can learn it, Fawase was a mathematic student in High School and he had no problem networking! He leverages his network for learning as he learns from his environment. Finally he increased his network globally by attending the Global Student Entrepreneur Award competition. Once again, there was no local competition in Sri Lanka but he reached out anyway to the organisation and ended up having an incredible time with the 35 GSEA finalists, all like minded people from across the globe. You can do it too , go visit GSEA.ORG and enroll in your local competition! If you have what it takes you can apply to share your story on air: www.studentpreneur.com.au

The clinical course of renal cell carcinoma (RCC) shows a high variability. Prognostic markers are essential to enable an individualized therapeutic strategy. The objective of this study was the identification of novel independent prognostic markers and potential therapeutic targets in RCC. The focus was on genes involved in epithelial-mesenchymal transition (EMT) and cancer stem cell biology. EMT enhances tumor cell motility and hence plays a critical role in invasion and metastasis in various carcinomas. A set of transcription factors acts as master regulators of EMT. Whether EMT is important for tumor progression in clear cell renal cell carcinoma (RCC) is unknown. Therefore, EMT-related genes were selected from the literature, and their role and prognostic relevance in RCC were analyzed. The known cancer stem cell marker CXCR4 and the associated TPBG gene were also analyzed in this project. Additionally, a novel filter strategy was used to analyze RCC oligonucleotide microarray data for identification of potential prognostic markers: genes with increasing expression during tumor progression (normal kidney < primary tumor < metastases) were selected for outcome analysis because they could be crucial for RCC biology. Expression of 46 EMT-related genes was analyzed using oligonucleotide microarrays and gene set enrichment analysis (GSEA) in tissue samples from normal kidney and G1 and G3 primary RCC, 14 samples each. Expression of selected EMT genes was validated by real-time polymerase chain reaction (PCR) in normal kidney, primary RCC and metastases in an independent cohort of 112 patients and then combined with follow-up data for survival analysis. Immunohistochemistry, Western blot and flow cytometry were performed to further examine the expression of CXCR4 and co-expression of CXCR4 and TPBG on the surface of RCC cells. GSEA and dChip software were used for microarray data analysis. The EMT gene set was preferentially expressed in primary tumors compared to normal tissue (false discovery rate FDR=0.01), but no difference between G1 and G3 tumors was found. Quantitative RT-PCR showed down-regulation of critical EMT genes like CDH2 and ZEB1 in metastases which suggests reversal of EMT during metastasis. Kaplan-Meier analysis demonstrated a significant better outcome for patients with low CXCR4, vimentin, fibronectin and TWIST1 mRNA levels. Multivariate analysis revealed that CXCR4 and vimentin up-regulation represent independent prognostic markers for poor cancer-specific survival of RCC patients. The microarray approach using filtering and further RT-PCR validation of progression-associated genes revealed that ATAD2, TET3, HELLS and TOP2A are independent and previously unknown predictors of poor outcome in RCC patients. Taken together, this study provides strong evidence that EMT occurs in RCC. Modulation of EMT in RCC, therefore, might represent a future therapeutic option. Expression levels of a number of EMT-related genes (like the genes encoding the cancer stem cell marker CXCR4 and vimentin) could be identified as independent prognostic markers. Using a novel filtering approach on array data, additional novel prognostic markers could be identified. These findings contribute to a better risk stratification of RCC patients that can support an individualized and optimized therapeutic strategy.

The goal of bioinformatics is to develop innovative and practical methods and algorithms for bio- logical questions. In many cases, these questions are driven by new biotechnological techniques, especially by genome and cell wide high throughput experiment studies. In principle there are two approaches: 1. Reduction and abstraction of the question to a clearly defined optimization problem, which can be solved with appropriate and efficient algorithms. 2. Development of context based methods, incorporating as much contextual knowledge as possible in the algorithms, and derivation of practical solutions for relevant biological ques- tions on the high-throughput data. These methods can be often supported by appropriate software tools and visualizations, allowing for interactive evaluation of the results by ex- perts. Context based methods are often much more complex and require more involved algorithmic techniques to get practical relevant and efficient solutions for real world problems, as in many cases already the simplified abstraction of problems result in NP-hard problem instances. In many cases, to solve these complex problems, one needs to employ efficient data structures and heuristic search methods to solve clearly defined sub-problems using efficient (polynomial) op- timization (such as dynamic programming, greedy, path- or tree-algorithms). In this thesis, we present new methods and analyses addressing open questions of bioinformatics from different contexts by incorporating the corresponding contextual knowledge. The two main contexts in this thesis are the protein structure similarity context (Part I) and net- work based interpretation of high-throughput data (Part II). For the protein structure similarity context Part I we analyze the consistency of gold standard structure classification systems and derive a consistent benchmark set usable for different ap- plications. We introduce two methods (Vorolign, PPM) for the protein structure similarity recog- nition problem, based on different features of the structures. Derived from the idea and results of Vorolign, we introduce the concept of contact neighbor- hood potential, aiming to improve the results of protein fold recognition and threading. For the re-scoring problem of predicted structure models we introduce the method Vorescore, clearly improving the fold-recognition performance, and enabling the evaluation of the contact neighborhood potential for structure prediction methods in general. We introduce a contact consistent Vorolign variant ccVorolign further improving the structure based fold recognition performance, and enabling direct optimization of the neighborhood po- tential in the future. Due to the enforcement of contact-consistence, the ccVorolign method has much higher computational complexity than the polynomial Vorolign method - the cost of com- puting interpretable and consistent alignments. Finally, we introduce a novel structural alignment method (PPM) enabling the explicit modeling and handling of phenotypic plasticity in protein structures. We employ PPM for the analysis of effects of alternative splicing on protein structures. With the help of PPM we test the hypothesis, whether splice isoforms of the same protein can lead to protein structures with different folds (fold transitions). In Part II of the thesis we present methods generating and using context information for the interpretation of high-throughput experiments. For the generation of context information of molecular regulations we introduce novel textmin- ing approaches extracting relations automatically from scientific publications. In addition to the fast NER (named entity recognition) method (syngrep) we also present a novel, fully ontology-based context-sensitive method (SynTree) allowing for the context-specific dis- ambiguation of ambiguous synonyms and resulting in much better identification performance. This context information is important for the interpretation of high-throughput data, but often missing in current databases. Despite all improvements, the results of automated text-mining methods are error prone. The RelAnn application presented in this thesis helps to curate the automatically extracted regula- tions enabling manual and ontology based curation and annotation. For the usage of high-throughput data one needs additional methods for data processing, for example methods to map the hundreds of millions short DNA/RNA fragments (so called reads) on a reference genome or transcriptome. Such data (RNA-seq reads) are the output of next generation sequencing methods measured by sequencing machines, which are becoming more and more efficient and affordable. Other than current state-of-the-art methods, our novel read-mapping method ContextMap re- solves the occurring ambiguities at the final step of the mapping process, employing thereby the knowledge of the complete set of possible ambiguous mappings. This approach allows for higher precision, even if more nucleotide errors are tolerated in the read mappings in the first step. The consistence between context information of molecular regulations stored in databases and extracted from textmining against measured data can be used to identify and score consistent reg- ulations (GGEA). This method substantially extends the commonly used gene-set based methods such over-representation (ORA) and gene set enrichment analysis (GSEA). Finally we introduce the novel method RelExplain, which uses the extracted contextual knowl- edge and generates network-based and testable hypotheses for the interpretation of high-throughput data.

There are hints of an altered mitochondrial function in obesity. Nuclear-encoded genes are relevant for mitochondrial function (3 gene sets of known relevant pathways: (1) 16 nuclear regulators of mitochondrial genes, (2) 91 genes for oxidative phosphorylation and (3) 966 nuclear-encoded mitochondrial genes). Gene set enrichment analysis (GSEA) showed no association with type 2 diabetes mellitus in these gene sets. Here we performed a GSEA for the same gene sets for obesity. Genome wide association study (GWAS) data from a case-control approach on 453 extremely obese children and adolescents and 435 lean adult controls were used for GSEA. For independent confirmation, we analyzed 705 obesity GWAS trios (extremely obese child and both biological parents) and a population-based GWAS sample (KORA F4, n = 1,743). A meta-analysis was performed on all three samples. In each sample, the distribution of significance levels between the respective gene set and those of all genes was compared using the leading-edge-fraction-comparison test (cut-offs between the 50(th) and 95(th) percentile of the set of all gene-wise corrected p-values) as implemented in the MAGENTA software. In the case-control sample, significant enrichment of associations with obesity was observed above the 50(th) percentile for the set of the 16 nuclear regulators of mitochondrial genes (p(GSEA,50) = 0.0103). This finding was not confirmed in the trios (p(GSEA,50) = 0.5991), but in KORA (p(GSEA,50) = 0.0398). The meta-analysis again indicated a trend for enrichment (p(MAGENTA,50) = 0.1052, p(MAGENTA,75) = 0.0251). The GSEA revealed that weak association signals for obesity might be enriched in the gene set of 16 nuclear regulators of mitochondrial genes.

Doug Beebe, Board Chair of Georgia Solar Energy Association, will join us as discuss all the exciting developments in Georgia's Solar industry. In addition to his work at the Georgia Solar Energy Association, Doug works for Deutsche Leasing USA, the US subsidiary of a German leasing company. While growing their traditional equipment finance business in the US, Doug is also developing a solar finance business at Deutsche Leasing USA.  In the past, Doug has held leadership roles in sales, marketing, operations and management at GE Capital and Citigroup during his career in equipment finance.  Doug holds a B.A. degree in Economics and International Studies from The University of North Carolina at Chapel Hill and has a working knowledge of French and speaks basic Turkish. He attained NABCEP’s Entry Level Certificate of Knowledge in Solar Photovoltaics and continues his education in the solar industry.  He lives in Decatur with his wife, Tijen and daughter, Aleyna.

The Georgia Solar Energy Association leads the statewide effort to promote the economic and environmental benefits of solar energy through education, advocacy and industry support. Our members are working together to make Georgia a leader in sustainable energy and green job growth.